5B8IA

Crystal structure of calcineurin a and calcineurin b in complex with fkbp12 and fk506 from coccidioides immitis rs
Total Genus 124
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
124
sequence length
359
structure length
359
Chain Sequence
LERVCKEVQAPAFHTPTNEQFWSPVDPSKPNLAFLKQHFYREGRLTEDQALWIIQAGTELLRAEPNLLEMDAPITVCGDVHGQYYDLMKLFEVGGDPAETRYLFLGDYVDRGYFSIECVLYLWALKIWYPNTLWLLRGNHECRHLTDYFTFKLECKHKYSEKVYDACMESFCALPLAAIMNKQFLCIHGGLSPELHTLEDIKSIDRFREPPTHGLMCDILWADPLEDFGTEKTGEYFVHNNVRGCSFFFSYPAACAFLEKNNLLSIIRAHEAQDAGYRMYQKTRTTGFPSVMTIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCTPHPYWLPNFMDVFTWSLPFVGEKITDMLIAILN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structure of Calcineurin A and Calcineurin B in complex with FKBP12 and FK506 from Coccidioides immitis RS
rcsb
molecule tags Hydrolase
source organism Coccidioides immitis (strain rs)
molecule keywords Serine/threonine-protein phosphatase
total genus 124
structure length 359
sequence length 359
ec nomenclature ec 3.1.3.16: Protein-serine/threonine phosphatase.
pdb deposition date 2015-05-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00149 Metallophos Calcineurin-like phosphoesterase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 5b8iA00
4HD0A 1S3MA 2Z72A 4LTYA 1MF8A 4YKEA 3CK2A 3ZU0A 5JPFA 3N5UA 4I5NC 5HPEA 1S70A 4DSYA 4O4KA 1WAO1 2CV9A 3THNA 2NYLC 4UT3B 3EGHA 3QFMA 3IB7A 4H1SA 1AUIA 2O8AA 2WDDA 2AHDA 2BDXA 3E7BA 4FBKA 4IYPC 4ZVZA 5IOHA 4ORBA 1HPUA 3E7AA 2NYMC 5EQVA 3THOB 4UT2A 2IE3C 3ICFA 1UTEA 4JA7A 3QG5C 4O5GA 4FCXA 1T71A 4V0WA 4UT3A 2JOGA 3H63A 1T70A 4MOYA 4V0VA 1XZWA 4FBQA 2HYPA 3RL3A 3H67A 4H2FA 3RL4A 3H69A 1G5BA 1S3LA 4JA9A 2HY1A 2Z1AA 4H2IA 4TUIA 2KKNA 4ORCA 3EGGA 5INBA 3HVQA 1QFCA 3P71C 3PSOA 2O8GA 1OIDA 4DHLA 1S3NA 4KKZA 4DT2A 2Z06A 3IB8A 4UWQA 3V4YA 3K7VC 2USHA 3KBPA 2P6BA 1Z2XA 1OIEA 4M0VA 3RL5A 4FBWA 5JPEA 2R17A 1FJMA 4G9JA 2QFRA 2WDEA 3ZTVA 2GJUA 3IVDA 3RQZA 4LACC 2YVTA 1KBPA 2XMOA 1QHWA 3AV0A 1UF3A 3K7WC 4ZX2A 2BCDA 3QFOA 4OR9A 1OI8A 2A22A 3TGHA 1TCOA 1HP1A 2NXFA 4IL1A 5B8IA 2QFPA 1II7A 3QFKA 3T1IA 1IT6A 3H66A 2DFJA 3DSDA 4B2OA 5C1VA 4WWLA 3H62B 4KBPA 2IAEC 2WDFA 5GTUA 3QFNA 3H61A 1USHA 5F3WA 3C5WC 4I5LC 4XPNA 3DSCA 4O43A 4TUGA 4F0ZA 4O24A 4MOVA 3PSNA 2QJCA 2ZBMA 4J6OA 2BQ8X 4ORAA 4H2GA 1S95A 5JJTA 5J28A 4V0XA 4H1YP 3C9FA 3H64A 2IE4C 2Q8UA 3DW8C 2WDCA 3FGAC 1M63A 5DNYA 3IVEA 3AUZA 3H68A 3GVEA 1U32A 1V73A 4LU9A 1W24A 4MP0A 1NNWA 4Q7FA 4NZVA 2NPPC 3LL8A 1S8EA 4H2BA 1HO5A 2HYOA 3JYFA 1SU1A 1Z2WA 1WARA 1JK7A 1XM7A 3H60A
chains in the Genus database with same CATH superfamily
4HD0A 1S3MA 2Z72A 4LTYA 1MF8A 2ZO9B 3CK2A 4YKEA 3ZU0A 5JPFA 3N5UA 4I5NC 5HPEA 1S70A 4DSYA 4O4KA 1WAO1 2CV9A 3THNA 2NYLC 4UT3B 3EGHA 3QFMA 3IB7A 4H1SA 1AUIA 2O8AA 2WDDA 2AHDA 2BDXA 3E7BA 4FBKA 4IYPC 4ZVZA 5IOHA 4ORBA 1HPUA 3E7AA 2NYMC 2YEQA 5EQVA 3THOB 4UT2A 2IE3C 3ICFA 1UTEA 4JA7A 3QG5C 4O5GA 4FCXA 1T71A 4V0WA 4UT3A 2JOGA 3H63A 1T70A 4MOYA 4V0VA 1XZWA 4FBQA 2HYPA 3RL3A 3H67A 4H2FA 3RL4A 3H69A 1G5BA 1S3LA 4JA9A 2HY1A 2Z1AA 4H2IA 4TUIA 2KKNA 4ORCA 3EGGA 5INBA 3HVQA 1QFCA 3P71C 3PSOA 2O8GA 1OIDA 4DHLA 1S3NA 4KKZA 2ZOAA 4DT2A 2Z06A 3IB8A 4UWQA 3V4YA 3K7VC 2USHA 3D03A 3KBPA 2P6BA 1Z2XA 1OIEA 4M0VA 3RL5A 4FBWA 5JPEA 2R17A 1FJMA 4G9JA 2QFRA 2WDEA 3ZTVA 2GJUA 3IVDA 3RQZA 4LACC 2YVTA 1KBPA 2XMOA 1QHWA 3AV0A 1UF3A 3K7WC 4ZX2A 2BCDA 3QFOA 4OR9A 1OI8A 2A22A 3TGHA 1TCOA 1HP1A 2NXFA 4IL1A 5B8IA 2QFPA 1II7A 2DXNA 3QFKA 3T1IA 1IT6A 3H66A 2DFJA 3DSDA 4B2OA 5C1VA 4WWLA 3H62B 4KBPA 2IAEC 2WDFA 5GTUA 3QFNA 3H61A 1USHA 5F3WA 3C5WC 4I5LC 4XPNA 3DSCA 3E0JA 4O43A 4TUGA 4F0ZA 3FLOA 4O24A 4MOVA 3PSNA 2QJCA 2ZBMA 4J6OA 2BQ8X 2DXLA 4ORAA 4H2GA 1S95A 5JJTA 5J28A 4V0XA 4H1YP 3C9FA 3H64A 2IE4C 2Q8UA 3DW8C 2WDCA 3FGAC 1M63A 5DNYA 3IVEA 3AUZA 3H68A 3GVEA 1U32A 1V73A 4LU9A 1W24A 4MP0A 1NNWA 4Q7FA 4NZVA 2NPPC 3LL8A 1S8EA 4H2BA 1HO5A 2HYOA 3JYFA 1SU1A 1Z2WA 1WARA 1JK7A 1XM7A 3H60A
chains in the Genus database with same CATH topology
4HD0A 1S3MA 2Z72A 4LTYA 1MF8A 2ZO9B 3CK2A 4YKEA 3ZU0A 5JPFA 3N5UA 4I5NC 5HPEA 1S70A 4DSYA 4O4KA 1WAO1 2CV9A 3THNA 2NYLC 4UT3B 3EGHA 3QFMA 3IB7A 4H1SA 1AUIA 2O8AA 2WDDA 2AHDA 2BDXA 3E7BA 4FBKA 4IYPC 4ZVZA 5IOHA 4ORBA 1HPUA 3E7AA 2NYMC 2YEQA 5EQVA 3THOB 4UT2A 2IE3C 3ICFA 1UTEA 4JA7A 3QG5C 4O5GA 4FCXA 1T71A 4V0WA 4UT3A 2JOGA 3H63A 1T70A 4MOYA 4V0VA 1XZWA 4FBQA 2HYPA 3RL3A 3H67A 4H2FA 3RL4A 3H69A 1G5BA 1S3LA 4JA9A 2HY1A 2Z1AA 4H2IA 4TUIA 2KKNA 4ORCA 3EGGA 5INBA 3HVQA 1QFCA 3P71C 3PSOA 2O8GA 1OIDA 4DHLA 1S3NA 4KKZA 2ZOAA 4DT2A 2Z06A 3IB8A 4UWQA 3V4YA 3K7VC 2USHA 3D03A 3KBPA 2P6BA 1Z2XA 1OIEA 4M0VA 3RL5A 4FBWA 5JPEA 2R17A 1FJMA 4G9JA 2QFRA 2WDEA 3ZTVA 2GJUA 3IVDA 3RQZA 4LACC 2YVTA 1KBPA 2XMOA 1QHWA 3AV0A 1UF3A 3K7WC 4ZX2A 2BCDA 3QFOA 4OR9A 1OI8A 2A22A 3TGHA 1TCOA 1HP1A 2NXFA 4IL1A 5B8IA 2QFPA 1II7A 2DXNA 3QFKA 3T1IA 1IT6A 3H66A 2DFJA 3DSDA 4B2OA 5C1VA 4WWLA 3H62B 4KBPA 2IAEC 2WDFA 5GTUA 3QFNA 3H61A 1USHA 5F3WA 3C5WC 4I5LC 4XPNA 3DSCA 3E0JA 4O43A 4TUGA 4F0ZA 3FLOA 4O24A 4MOVA 3PSNA 2QJCA 2ZBMA 4J6OA 2BQ8X 2DXLA 4ORAA 4H2GA 1S95A 5JJTA 5J28A 4V0XA 4H1YP 3C9FA 3H64A 2IE4C 2Q8UA 3DW8C 2WDCA 3FGAC 1M63A 5DNYA 3IVEA 3AUZA 3H68A 3GVEA 1U32A 1V73A 4LU9A 1W24A 4MP0A 1NNWA 4Q7FA 4NZVA 2NPPC 3LL8A 1S8EA 4H2BA 1HO5A 2HYOA 3JYFA 1SU1A 1Z2WA 1WARA 1JK7A 1XM7A 3H60A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4HD0 A;  1S3M A;  2Z72 A;  4LTY A;  1MF8 A;  4YKE A;  3CK2 A;  3ZU0 A;  5JPF A;  3N5U A;  4I5N C;  5HPE A;  1S70 A;  4DSY A;  4O4K A;  1WAO 1;  2CV9 A;  3THN A;  2NYL C;  4UT3 B;  3EGH A;  3QFM A;  3IB7 A;  4H1S A;  1AUI A;  2O8A A;  2WDD A;  2AHD A;  2BDX A;  3E7B A;  4FBK A;  4IYP C;  4ZVZ A;  5IOH A;  4ORB A;  1HPU A;  3E7A A;  2NYM C;  5EQV A;  3THO B;  4UT2 A;  2IE3 C;  3ICF A;  1UTE A;  4JA7 A;  3QG5 C;  4O5G A;  4FCX A;  1T71 A;  4V0W A;  4UT3 A;  2JOG A;  3H63 A;  1T70 A;  4MOY A;  4V0V A;  1XZW A;  4FBQ A;  2HYP A;  3RL3 A;  3H67 A;  4H2F A;  3RL4 A;  3H69 A;  1G5B A;  1S3L A;  4JA9 A;  2HY1 A;  2Z1A A;  4H2I A;  4TUI A;  2KKN A;  4ORC A;  3EGG A;  5INB A;  3HVQ A;  1QFC A;  3P71 C;  3PSO A;  2O8G A;  1OID A;  4DHL A;  1S3N A;  4KKZ A;  4DT2 A;  2Z06 A;  3IB8 A;  4UWQ A;  3V4Y A;  3K7V C;  2USH A;  3KBP A;  2P6B A;  1Z2X A;  1OIE A;  4M0V A;  3RL5 A;  4FBW A;  5JPE A;  2R17 A;  1FJM A;  4G9J A;  2QFR A;  2WDE A;  3ZTV A;  2GJU A;  3IVD A;  3RQZ A;  4LAC C;  2YVT A;  1KBP A;  2XMO A;  1QHW A;  3AV0 A;  1UF3 A;  3K7W C;  4ZX2 A;  2BCD A;  3QFO A;  4OR9 A;  1OI8 A;  2A22 A;  3TGH A;  1TCO A;  1HP1 A;  2NXF A;  4IL1 A;  5B8I A;  2QFP A;  1II7 A;  3QFK A;  3T1I A;  1IT6 A;  3H66 A;  2DFJ A;  3DSD A;  4B2O A;  5C1V A;  4WWL A;  3H62 B;  4KBP A;  2IAE C;  2WDF A;  5GTU A;  3QFN A;  3H61 A;  1USH A;  5F3W A;  3C5W C;  4I5L C;  4XPN A;  3DSC A;  4O43 A;  4TUG A;  4F0Z A;  4O24 A;  4MOV A;  3PSN A;  2QJC A;  2ZBM A;  4J6O A;  2BQ8 X;  4ORA A;  4H2G A;  1S95 A;  5JJT A;  5J28 A;  4V0X A;  4H1Y P;  3C9F A;  3H64 A;  2IE4 C;  2Q8U A;  3DW8 C;  2WDC A;  3FGA C;  1M63 A;  5DNY A;  3IVE A;  3AUZ A;  3H68 A;  3GVE A;  1U32 A;  1V73 A;  4LU9 A;  1W24 A;  4MP0 A;  1NNW A;  4Q7F A;  4NZV A;  2NPP C;  3LL8 A;  1S8E A;  4H2B A;  1HO5 A;  2HYO A;  3JYF A;  1SU1 A;  1Z2W A;  1WAR A;  1JK7 A;  1XM7 A;  3H60 A; 
#chains in the Genus database with same CATH topology
 4HD0 A;  1S3M A;  2Z72 A;  4LTY A;  1MF8 A;  2ZO9 B;  3CK2 A;  4YKE A;  3ZU0 A;  5JPF A;  3N5U A;  4I5N C;  5HPE A;  1S70 A;  4DSY A;  4O4K A;  1WAO 1;  2CV9 A;  3THN A;  2NYL C;  4UT3 B;  3EGH A;  3QFM A;  3IB7 A;  4H1S A;  1AUI A;  2O8A A;  2WDD A;  2AHD A;  2BDX A;  3E7B A;  4FBK A;  4IYP C;  4ZVZ A;  5IOH A;  4ORB A;  1HPU A;  3E7A A;  2NYM C;  2YEQ A;  5EQV A;  3THO B;  4UT2 A;  2IE3 C;  3ICF A;  1UTE A;  4JA7 A;  3QG5 C;  4O5G A;  4FCX A;  1T71 A;  4V0W A;  4UT3 A;  2JOG A;  3H63 A;  1T70 A;  4MOY A;  4V0V A;  1XZW A;  4FBQ A;  2HYP A;  3RL3 A;  3H67 A;  4H2F A;  3RL4 A;  3H69 A;  1G5B A;  1S3L A;  4JA9 A;  2HY1 A;  2Z1A A;  4H2I A;  4TUI A;  2KKN A;  4ORC A;  3EGG A;  5INB A;  3HVQ A;  1QFC A;  3P71 C;  3PSO A;  2O8G A;  1OID A;  4DHL A;  1S3N A;  4KKZ A;  2ZOA A;  4DT2 A;  2Z06 A;  3IB8 A;  4UWQ A;  3V4Y A;  3K7V C;  2USH A;  3D03 A;  3KBP A;  2P6B A;  1Z2X A;  1OIE A;  4M0V A;  3RL5 A;  4FBW A;  5JPE A;  2R17 A;  1FJM A;  4G9J A;  2QFR A;  2WDE A;  3ZTV A;  2GJU A;  3IVD A;  3RQZ A;  4LAC C;  2YVT A;  1KBP A;  2XMO A;  1QHW A;  3AV0 A;  1UF3 A;  3K7W C;  4ZX2 A;  2BCD A;  3QFO A;  4OR9 A;  1OI8 A;  2A22 A;  3TGH A;  1TCO A;  1HP1 A;  2NXF A;  4IL1 A;  5B8I A;  2QFP A;  1II7 A;  2DXN A;  3QFK A;  3T1I A;  1IT6 A;  3H66 A;  2DFJ A;  3DSD A;  4B2O A;  5C1V A;  4WWL A;  3H62 B;  4KBP A;  2IAE C;  2WDF A;  5GTU A;  3QFN A;  3H61 A;  1USH A;  5F3W A;  3C5W C;  4I5L C;  4XPN A;  3DSC A;  3E0J A;  4O43 A;  4TUG A;  4F0Z A;  3FLO A;  4O24 A;  4MOV A;  3PSN A;  2QJC A;  2ZBM A;  4J6O A;  2BQ8 X;  2DXL A;  4ORA A;  4H2G A;  1S95 A;  5JJT A;  5J28 A;  4V0X A;  4H1Y P;  3C9F A;  3H64 A;  2IE4 C;  2Q8U A;  3DW8 C;  2WDC A;  3FGA C;  1M63 A;  5DNY A;  3IVE A;  3AUZ A;  3H68 A;  3GVE A;  1U32 A;  1V73 A;  4LU9 A;  1W24 A;  4MP0 A;  1NNW A;  4Q7F A;  4NZV A;  2NPP C;  3LL8 A;  1S8E A;  4H2B A;  1HO5 A;  2HYO A;  3JYF A;  1SU1 A;  1Z2W A;  1WAR A;  1JK7 A;  1XM7 A;  3H60 A; 
#chains in the Genus database with same CATH homology
 4HD0 A;  1S3M A;  2Z72 A;  4LTY A;  1MF8 A;  2ZO9 B;  3CK2 A;  4YKE A;  3ZU0 A;  5JPF A;  3N5U A;  4I5N C;  5HPE A;  1S70 A;  4DSY A;  4O4K A;  1WAO 1;  2CV9 A;  3THN A;  2NYL C;  4UT3 B;  3EGH A;  3QFM A;  3IB7 A;  4H1S A;  1AUI A;  2O8A A;  2WDD A;  2AHD A;  2BDX A;  3E7B A;  4FBK A;  4IYP C;  4ZVZ A;  5IOH A;  4ORB A;  1HPU A;  3E7A A;  2NYM C;  2YEQ A;  5EQV A;  3THO B;  4UT2 A;  2IE3 C;  3ICF A;  1UTE A;  4JA7 A;  3QG5 C;  4O5G A;  4FCX A;  1T71 A;  4V0W A;  4UT3 A;  2JOG A;  3H63 A;  1T70 A;  4MOY A;  4V0V A;  1XZW A;  4FBQ A;  2HYP A;  3RL3 A;  3H67 A;  4H2F A;  3RL4 A;  3H69 A;  1G5B A;  1S3L A;  4JA9 A;  2HY1 A;  2Z1A A;  4H2I A;  4TUI A;  2KKN A;  4ORC A;  3EGG A;  5INB A;  3HVQ A;  1QFC A;  3P71 C;  3PSO A;  2O8G A;  1OID A;  4DHL A;  1S3N A;  4KKZ A;  2ZOA A;  4DT2 A;  2Z06 A;  3IB8 A;  4UWQ A;  3V4Y A;  3K7V C;  2USH A;  3D03 A;  3KBP A;  2P6B A;  1Z2X A;  1OIE A;  4M0V A;  3RL5 A;  4FBW A;  5JPE A;  2R17 A;  1FJM A;  4G9J A;  2QFR A;  2WDE A;  3ZTV A;  2GJU A;  3IVD A;  3RQZ A;  4LAC C;  2YVT A;  1KBP A;  2XMO A;  1QHW A;  3AV0 A;  1UF3 A;  3K7W C;  4ZX2 A;  2BCD A;  3QFO A;  4OR9 A;  1OI8 A;  2A22 A;  3TGH A;  1TCO A;  1HP1 A;  2NXF A;  4IL1 A;  5B8I A;  2QFP A;  1II7 A;  2DXN A;  3QFK A;  3T1I A;  1IT6 A;  3H66 A;  2DFJ A;  3DSD A;  4B2O A;  5C1V A;  4WWL A;  3H62 B;  4KBP A;  2IAE C;  2WDF A;  5GTU A;  3QFN A;  3H61 A;  1USH A;  5F3W A;  3C5W C;  4I5L C;  4XPN A;  3DSC A;  3E0J A;  4O43 A;  4TUG A;  4F0Z A;  3FLO A;  4O24 A;  4MOV A;  3PSN A;  2QJC A;  2ZBM A;  4J6O A;  2BQ8 X;  2DXL A;  4ORA A;  4H2G A;  1S95 A;  5JJT A;  5J28 A;  4V0X A;  4H1Y P;  3C9F A;  3H64 A;  2IE4 C;  2Q8U A;  3DW8 C;  2WDC A;  3FGA C;  1M63 A;  5DNY A;  3IVE A;  3AUZ A;  3H68 A;  3GVE A;  1U32 A;  1V73 A;  4LU9 A;  1W24 A;  4MP0 A;  1NNW A;  4Q7F A;  4NZV A;  2NPP C;  3LL8 A;  1S8E A;  4H2B A;  1HO5 A;  2HYO A;  3JYF A;  1SU1 A;  1Z2W A;  1WAR A;  1JK7 A;  1XM7 A;  3H60 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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