5IYBL

Human core-pic in the open state
Total Genus 3
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
3
sequence length
46
structure length
46
Chain Sequence
QPMIYICGECHTENEIKSRDPIRCRECGYRIMYKKRTKRLVVFDAR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Near-atomic resolution visualization of human transcription promoter opening.
pubmed doi rcsb
molecule tags Transcription, transferase/dna
source organism Homo sapiens
molecule keywords DNA-directed RNA polymerase II subunit RPB1
total genus 3
structure length 46
sequence length 46
ec nomenclature
pdb deposition date 2016-03-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
L PF03604 DNA_RNApol_7kD DNA directed RNA polymerase, 7 kDa subunit
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.20.28.30 Mainly Beta Single Sheet Rubrerythrin, domain 2 RNA polymerase ii, chain L 5iybL00
3PO2L 1TWAL 5C44L 2R7ZL 4A3JL 3S1RL 1TWGL 3HOUL 2JA6L 5C4XL 3S1ML 5C3EL 4BY1L 3RZOL 1TWHL 1Y1WL 1I6HL 3S1QL 3I4ML 3HKZP 3HOWL 3PO3L 5IP9L 3GTOL 2YU9L 1R9TL 3GTKL 1I3QL 3GTJL 2B63L 1I50L 2NVTL 5M5WL 2E2HL 3RZDL 4A3IL 3S2DL 4X6AL 1K83L 3K7AL 2WB1P 4C3IL 3GTLL 5IYCL 5FLML 1SFOL 1Y1VL 4C3JL 3M4OL 4A3DL 1TWFL 5FJ8L 5IP7L 3HOXL 4A3EL 2R93L 3GTML 4A3LL 4BBRL 3S14L 4C2M1 4Y52L 3M3YL 2R92L 3GTPL 2JA8L 3HOVL 4BY7L 5M3FL 2E2IL 2E2JL 5M5XL 3S17L 2NVXL 2VUML 3S15L 4A3FL 3GTGL 1WCML 5IYDL 3GTQL 4A93L 4A3CL 2JA5L 3S2HL 3HOYL 2NVYL 5C4JL 3S16L 4C3HL 5M3ML 4A3ML 2PMZP 3I4NL 3CQZL 4AYBP 4A3KL 4BXXL 3S1NL 3H3VM 3HOZL 4A3BL 2Y0SP 3FKIL 4QIWP 5M5YL 2WAQP 2JA7L 1TWCL 4A3GL 3H0GL 2NVQL 4BBSL 5IYBL 4Y7NL
chains in the Genus database with same CATH superfamily
1R0JA 2R7ZL 4A3JL 2ZIXA 5K2ME 3HOUL 1LKPA 4V196 4TVMA 3RZOL 1RDVA 1E8JA 1NNQA 2PPTA 3S1QL 4AI0A 2JI1A 4GS7D 5H1Sc 3LWOB 5JVG1 3GTKL 4U671 1P7PA 2NVTL 3LWPB 3KYUA 2E2HL 2LCQA 3LWRB 4UY81 3JR7A 4AHXA 3HJYB 1PFVA 2BE5D 3PWFA 3NFPI 5RXNA 4C3JL 3HOXL 2R93L 4BBRL 4TPUA 1PFWA 2XJSA 1LKMA 1YUXA 3GTPL 4JADA 4JAEA 4BY7L 5M3FL 5GAGc 1YK5A 5M5XL 3S17L 2NVXL 1LKOA 7RXNA 1S2ZA 2APOB 5IY0A 1DVBA 4A3CL 2JA5L 1YV1A 1H7VA 1R0GA 3S16L 4A3ML 1B13A 3I4NL 5AI2A 1R0HA 1S24A 2PYAA 4A3KL 1IROA 4POGA 3J7Y1 3HOZL 2Y0SP 5M5YL 2V3BB 2CR8A 4AHYA 2WAQP 2JA7L 1TWCL 4ME3A 4BBSL 4AI1A 5IYBL 1QQTA 1JYBA 1TWAL 1YUZA 3QQCE 4XGHA 3PIP1 2A68D 1R0FA 3S1ML 5C3EL 1VZGA 3H9CA 1TWHL 1RWDA 3I4ML 3HKZP 3HOWL 2ERSA 5IP9L 1CADA 2PVXA 1R9TL 3LWQB 4LHLA 4POFA 1I3QL 3GTJL 2AYJA 2B63L 2Z3RB 1OWBA 3S2DL 2B5ID 3H97A 2JI3A 1QCVA 3MSUA 3B08B 2WB1P 3FDJA 4C3IL 5FLML 3QVDA 1SFOL 3PL5A 5AN9H 1TWFL 5IP7L 4YWMA 2XJUA 3S14L 4Y52L 2KKDA 3M3YL 2V0EA 2R92L 2JA8L 1RYQA 1FHMA 2ERJA 4AHWA 2XJVA 3HAXC 3S15L 2A69D 4B8CD 2J9UB 5MFPA 1PFUA 3PZAA 3LPEB 2CKAA 4A3FL 1VCXA 1WCML 1IU5A 2JI2A 4C3HL 1NXGA 5M3ML 1SMUA 4YWLA 4BXXL 4AR3A 2VL6A 3FKIL 2M4VA 2NYDA 1IU6A 1B71A 1Z92B 5MF6A 1FHHA 4A3GL 2RFKB 4K9FA 1BQ8A 5GAHc 1CAAA 2A6ED 1TWGL 2C6BA 2AUSB 2JA6L 1F4LA 4AI3A 4BY1L 2K2DA 1Y1WL 3PO3L 4ZN1B 5MFZA 3KYYA 2YU9L 3PKIA 2XJPA 1I50L 2DSXA 5M5WL 5AI3A 4A3IL 3SS2A 1PZXA 5GAEc 4AHZA 8RXNA 2PVEA 3H99A 2L0ZA 1BFYA 4X6AL 1R0IA 3LWVB 2HR5A 2Z3QB 3K7AL 5EINC 5MGNA 3H9BA 4A3DL 1QYBA 5FJ8L 4A3EL 2CKCA 5DM71 4JAFA 3J7Z1 1LTLA 2VUML 3ZG6A 5IYDL 4WFN1 4A93L 3S2HL 3HOYL 2PMZP 4E6YA 2PSMC 3CQZL 1BE7A 3S1NL 1PFYA 1OWCA 5MLC3 3RYGA 3RZ6A 3H3VM 1VZHA 1YK4A 3B0AB 3LNLA 2HVYC 4G6BA 5JVH1 3RZTA 3KYWA 2NVQL 1DX8A 3PIO1 3VPBE 3PO2L 5C44L 1C09A 3WWLA 3S1RL 2M6OA 3K35A 5C4XL 3WWNB 2XJRA 1NXEA 2RDVA 1SMWA 1ODHA 2KN9A 1I6HL 2A6HD 1RYTA 3GTOL 3P8BA 5DM61 4AR4A 6RXNA 1ZRPA 2AQCA 3RZDL 1VZIA 4XXBB 2H12A 3KYVA 4JAGA 2C6AA 1K83L 1T9PA 1RB9A 3GTLL 1IW7D 2V0FA 5IYCL 4AR5A 1Y1VL 4AI2A 3M4OL 3IU3I 1B2OA 1S30A 3GTML 4A3LL 2XJQA 4C2M1 3HJWB 3MQKB 2XJTA 2M6PA 1WJVA 3HOVL 2GMGA 2E2IL 4AR6A 2E2JL 2EY4E 2O5JD 2MS3A 2M4YA 1SMMA 3GTGL 3GTQL 5EIOC 3PKJA 1T9OA 2NVYL 1BQ9A 5C4JL 3P2AA 1IRNA 4RXNA 4AYBP 3A44A 4A3BL 3KYXA 4QIWP 1RDGA 3MPSA 1BRFA 1T9QA 3H0GL 1B2JA 4ZN3B 4LHNA 2QL0A 4Y7NL 5GADc
chains in the Genus database with same CATH topology
3PO2L 1TWAL 5C44L 2R7ZL 4A3JL 3S1RL 1TWGL 3HOUL 2JA6L 5C4XL 3S1ML 5C3EL 4BY1L 3RZOL 1TWHL 1Y1WL 1I6HL 3S1QL 3I4ML 3HKZP 3HOWL 3PO3L 5IP9L 3GTOL 2YU9L 1R9TL 3GTKL 1I3QL 3GTJL 2B63L 1I50L 2NVTL 5M5WL 2E2HL 3RZDL 4A3IL 3S2DL 4X6AL 1K83L 3K7AL 2WB1P 4C3IL 3GTLL 5IYCL 5FLML 1SFOL 1Y1VL 4C3JL 3M4OL 4A3DL 1TWFL 5FJ8L 5IP7L 3HOXL 4A3EL 2R93L 3GTML 4A3LL 4BBRL 3S14L 4C2M1 4Y52L 3M3YL 2R92L 3GTPL 2JA8L 3HOVL 4BY7L 5M3FL 2E2IL 2E2JL 5M5XL 3S17L 2NVXL 2VUML 3S15L 4A3FL 3GTGL 1WCML 5IYDL 3GTQL 4A93L 4A3CL 2JA5L 3S2HL 3HOYL 2NVYL 5C4JL 3S16L 4C3HL 5M3ML 4A3ML 2PMZP 3I4NL 3CQZL 4AYBP 4A3KL 4BXXL 3S1NL 3H3VM 3HOZL 4A3BL 2Y0SP 3FKIL 4QIWP 5M5YL 2WAQP 2JA7L 1TWCL 4A3GL 3H0GL 2NVQL 4BBSL 5IYBL 4Y7NL
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3PO2 L;  1TWA L;  5C44 L;  2R7Z L;  4A3J L;  3S1R L;  1TWG L;  3HOU L;  2JA6 L;  5C4X L;  3S1M L;  5C3E L;  4BY1 L;  3RZO L;  1TWH L;  1Y1W L;  1I6H L;  3S1Q L;  3I4M L;  3HKZ P;  3HOW L;  3PO3 L;  5IP9 L;  3GTO L;  2YU9 L;  1R9T L;  3GTK L;  1I3Q L;  3GTJ L;  2B63 L;  1I50 L;  2NVT L;  5M5W L;  2E2H L;  3RZD L;  4A3I L;  3S2D L;  4X6A L;  1K83 L;  3K7A L;  2WB1 P;  4C3I L;  3GTL L;  5IYC L;  5FLM L;  1SFO L;  1Y1V L;  4C3J L;  3M4O L;  4A3D L;  1TWF L;  5FJ8 L;  5IP7 L;  3HOX L;  4A3E L;  2R93 L;  3GTM L;  4A3L L;  4BBR L;  3S14 L;  4C2M 1;  4Y52 L;  3M3Y L;  2R92 L;  3GTP L;  2JA8 L;  3HOV L;  4BY7 L;  5M3F L;  2E2I L;  2E2J L;  5M5X L;  3S17 L;  2NVX L;  2VUM L;  3S15 L;  4A3F L;  3GTG L;  1WCM L;  5IYD L;  3GTQ L;  4A93 L;  4A3C L;  2JA5 L;  3S2H L;  3HOY L;  2NVY L;  5C4J L;  3S16 L;  4C3H L;  5M3M L;  4A3M L;  2PMZ P;  3I4N L;  3CQZ L;  4AYB P;  4A3K L;  4BXX L;  3S1N L;  3H3V M;  3HOZ L;  4A3B L;  2Y0S P;  3FKI L;  4QIW P;  5M5Y L;  2WAQ P;  2JA7 L;  1TWC L;  4A3G L;  3H0G L;  2NVQ L;  4BBS L;  5IYB L;  4Y7N L; 
#chains in the Genus database with same CATH topology
 1R0J A;  2R7Z L;  4A3J L;  2ZIX A;  5K2M E;  3HOU L;  1LKP A;  4V19 6;  4TVM A;  3RZO L;  1RDV A;  1E8J A;  1NNQ A;  2PPT A;  3S1Q L;  4AI0 A;  2JI1 A;  4GS7 D;  5H1S c;  3LWO B;  5JVG 1;  3GTK L;  4U67 1;  1P7P A;  2NVT L;  3LWP B;  3KYU A;  2E2H L;  2LCQ A;  3LWR B;  4UY8 1;  3JR7 A;  4AHX A;  3HJY B;  1PFV A;  2BE5 D;  3PWF A;  3NFP I;  5RXN A;  4C3J L;  3HOX L;  2R93 L;  4BBR L;  4TPU A;  1PFW A;  2XJS A;  1LKM A;  1YUX A;  3GTP L;  4JAD A;  4JAE A;  4BY7 L;  5M3F L;  5GAG c;  1YK5 A;  5M5X L;  3S17 L;  2NVX L;  1LKO A;  7RXN A;  1S2Z A;  2APO B;  5IY0 A;  1DVB A;  4A3C L;  2JA5 L;  1YV1 A;  1H7V A;  1R0G A;  3S16 L;  4A3M L;  1B13 A;  3I4N L;  5AI2 A;  1R0H A;  1S24 A;  2PYA A;  4A3K L;  1IRO A;  4POG A;  3J7Y 1;  3HOZ L;  2Y0S P;  5M5Y L;  2V3B B;  2CR8 A;  4AHY A;  2WAQ P;  2JA7 L;  1TWC L;  4ME3 A;  4BBS L;  4AI1 A;  5IYB L;  1QQT A;  1JYB A;  1TWA L;  1YUZ A;  3QQC E;  4XGH A;  3PIP 1;  2A68 D;  1R0F A;  3S1M L;  5C3E L;  1VZG A;  3H9C A;  1TWH L;  1RWD A;  3I4M L;  3HKZ P;  3HOW L;  2ERS A;  5IP9 L;  1CAD A;  2PVX A;  1R9T L;  3LWQ B;  4LHL A;  4POF A;  1I3Q L;  3GTJ L;  2AYJ A;  2B63 L;  2Z3R B;  1OWB A;  3S2D L;  2B5I D;  3H97 A;  2JI3 A;  1QCV A;  3MSU A;  3B08 B;  2WB1 P;  3FDJ A;  4C3I L;  5FLM L;  3QVD A;  1SFO L;  3PL5 A;  5AN9 H;  1TWF L;  5IP7 L;  4YWM A;  2XJU A;  3S14 L;  4Y52 L;  2KKD A;  3M3Y L;  2V0E A;  2R92 L;  2JA8 L;  1RYQ A;  1FHM A;  2ERJ A;  4AHW A;  2XJV A;  3HAX C;  3S15 L;  2A69 D;  4B8C D;  2J9U B;  5MFP A;  1PFU A;  3PZA A;  3LPE B;  2CKA A;  4A3F L;  1VCX A;  1WCM L;  1IU5 A;  2JI2 A;  4C3H L;  1NXG A;  5M3M L;  1SMU A;  4YWL A;  4BXX L;  4AR3 A;  2VL6 A;  3FKI L;  2M4V A;  2NYD A;  1IU6 A;  1B71 A;  1Z92 B;  5MF6 A;  1FHH A;  4A3G L;  2RFK B;  4K9F A;  1BQ8 A;  5GAH c;  1CAA A;  2A6E D;  1TWG L;  2C6B A;  2AUS B;  2JA6 L;  1F4L A;  4AI3 A;  4BY1 L;  2K2D A;  1Y1W L;  3PO3 L;  4ZN1 B;  5MFZ A;  3KYY A;  2YU9 L;  3PKI A;  2XJP A;  1I50 L;  2DSX A;  5M5W L;  5AI3 A;  4A3I L;  3SS2 A;  1PZX A;  5GAE c;  4AHZ A;  8RXN A;  2PVE A;  3H99 A;  2L0Z A;  1BFY A;  4X6A L;  1R0I A;  3LWV B;  2HR5 A;  2Z3Q B;  3K7A L;  5EIN C;  5MGN A;  3H9B A;  4A3D L;  1QYB A;  5FJ8 L;  4A3E L;  2CKC A;  5DM7 1;  4JAF A;  3J7Z 1;  1LTL A;  2VUM L;  3ZG6 A;  5IYD L;  4WFN 1;  4A93 L;  3S2H L;  3HOY L;  2PMZ P;  4E6Y A;  2PSM C;  3CQZ L;  1BE7 A;  3S1N L;  1PFY A;  1OWC A;  5MLC 3;  3RYG A;  3RZ6 A;  3H3V M;  1VZH A;  1YK4 A;  3B0A B;  3LNL A;  2HVY C;  4G6B A;  5JVH 1;  3RZT A;  3KYW A;  2NVQ L;  1DX8 A;  3PIO 1;  3VPB E;  3PO2 L;  5C44 L;  1C09 A;  3WWL A;  3S1R L;  2M6O A;  3K35 A;  5C4X L;  3WWN B;  2XJR A;  1NXE A;  2RDV A;  1SMW A;  1ODH A;  2KN9 A;  1I6H L;  2A6H D;  1RYT A;  3GTO L;  3P8B A;  5DM6 1;  4AR4 A;  6RXN A;  1ZRP A;  2AQC A;  3RZD L;  1VZI A;  4XXB B;  2H12 A;  3KYV A;  4JAG A;  2C6A A;  1K83 L;  1T9P A;  1RB9 A;  3GTL L;  1IW7 D;  2V0F A;  5IYC L;  4AR5 A;  1Y1V L;  4AI2 A;  3M4O L;  3IU3 I;  1B2O A;  1S30 A;  3GTM L;  4A3L L;  2XJQ A;  4C2M 1;  3HJW B;  3MQK B;  2XJT A;  2M6P A;  1WJV A;  3HOV L;  2GMG A;  2E2I L;  4AR6 A;  2E2J L;  2EY4 E;  2O5J D;  2MS3 A;  2M4Y A;  1SMM A;  3GTG L;  3GTQ L;  5EIO C;  3PKJ A;  1T9O A;  2NVY L;  1BQ9 A;  5C4J L;  3P2A A;  1IRN A;  4RXN A;  4AYB P;  3A44 A;  4A3B L;  3KYX A;  4QIW P;  1RDG A;  3MPS A;  1BRF A;  1T9Q A;  3H0G L;  1B2J A;  4ZN3 B;  4LHN A;  2QL0 A;  4Y7N L;  5GAD c; 
#chains in the Genus database with same CATH homology
 3PO2 L;  1TWA L;  5C44 L;  2R7Z L;  4A3J L;  3S1R L;  1TWG L;  3HOU L;  2JA6 L;  5C4X L;  3S1M L;  5C3E L;  4BY1 L;  3RZO L;  1TWH L;  1Y1W L;  1I6H L;  3S1Q L;  3I4M L;  3HKZ P;  3HOW L;  3PO3 L;  5IP9 L;  3GTO L;  2YU9 L;  1R9T L;  3GTK L;  1I3Q L;  3GTJ L;  2B63 L;  1I50 L;  2NVT L;  5M5W L;  2E2H L;  3RZD L;  4A3I L;  3S2D L;  4X6A L;  1K83 L;  3K7A L;  2WB1 P;  4C3I L;  3GTL L;  5IYC L;  5FLM L;  1SFO L;  1Y1V L;  4C3J L;  3M4O L;  4A3D L;  1TWF L;  5FJ8 L;  5IP7 L;  3HOX L;  4A3E L;  2R93 L;  3GTM L;  4A3L L;  4BBR L;  3S14 L;  4C2M 1;  4Y52 L;  3M3Y L;  2R92 L;  3GTP L;  2JA8 L;  3HOV L;  4BY7 L;  5M3F L;  2E2I L;  2E2J L;  5M5X L;  3S17 L;  2NVX L;  2VUM L;  3S15 L;  4A3F L;  3GTG L;  1WCM L;  5IYD L;  3GTQ L;  4A93 L;  4A3C L;  2JA5 L;  3S2H L;  3HOY L;  2NVY L;  5C4J L;  3S16 L;  4C3H L;  5M3M L;  4A3M L;  2PMZ P;  3I4N L;  3CQZ L;  4AYB P;  4A3K L;  4BXX L;  3S1N L;  3H3V M;  3HOZ L;  4A3B L;  2Y0S P;  3FKI L;  4QIW P;  5M5Y L;  2WAQ P;  2JA7 L;  1TWC L;  4A3G L;  3H0G L;  2NVQ L;  4BBS L;  5IYB L;  4Y7N L; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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