5B8IA

Crystal structure of calcineurin a and calcineurin b in complex with fkbp12 and fk506 from coccidioides immitis rs
Total Genus 124
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
124
sequence length
359
structure length
359
Chain Sequence
LERVCKEVQAPAFHTPTNEQFWSPVDPSKPNLAFLKQHFYREGRLTEDQALWIIQAGTELLRAEPNLLEMDAPITVCGDVHGQYYDLMKLFEVGGDPAETRYLFLGDYVDRGYFSIECVLYLWALKIWYPNTLWLLRGNHECRHLTDYFTFKLECKHKYSEKVYDACMESFCALPLAAIMNKQFLCIHGGLSPELHTLEDIKSIDRFREPPTHGLMCDILWADPLEDFGTEKTGEYFVHNNVRGCSFFFSYPAACAFLEKNNLLSIIRAHEAQDAGYRMYQKTRTTGFPSVMTIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCTPHPYWLPNFMDVFTWSLPFVGEKITDMLIAILN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structure of Calcineurin A and Calcineurin B in complex with FKBP12 and FK506 from Coccidioides immitis RS
rcsb
molecule tags Hydrolase
source organism Coccidioides immitis (strain rs)
molecule keywords Serine/threonine-protein phosphatase
total genus 124
structure length 359
sequence length 359
ec nomenclature ec 3.1.3.16: Protein-serine/threonine phosphatase.
pdb deposition date 2015-05-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00149 Metallophos Calcineurin-like phosphoesterase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 5b8iA00
4J6OA 3AV0A 2NYLC 3LL8A 3DSCA 1G5BA 2ZBMA 4O4KA 3K7VC 4ORBA 1V73A 4ZVZA 2Q8UA 1T71A 4I5NC 3H67A 1SU1A 2CV9A 2WDEA 3EGGA 5C1VA 1S70A 4V0VA 4DT2A 4UT3A 2BQ8X 5IOHA 4JA7A 4LTYA 2BDXA 4LU9A 2Z72A 2YVTA 4ORAA 3T1IA 4O24A 5INBA 4FCXA 1OIEA 5GTUA 2IAEC 3C5WC 3IVDA 1T70A 2P6BA 1WARA 5JPEA 3QFNA 3H66A 2Z06A 3QFKA 4UT3B 2XMOA 1Z2XA 3H60A 3PSNA 3RL5A 3H69A 4DHLA 3IVEA 3TGHA 1MF8A 2IE4C 2JOGA 4Q7FA 4MP0A 3RL3A 1UF3A 2Z1AA 4FBQA 3ZU0A 4DSYA 3H64A 1TCOA 4H2FA 4JA9A 3HVQA 3RL4A 3K7WC 4WWLA 3IB8A 4O5GA 1WAO1 1XZWA 2NPPC 1AUIA 4MOVA 2QJCA 4LACC 4H1SA 4NZVA 3CK2A 1HPUA 4YKEA 1Z2WA 2A22A 4HD0A 4OR9A 4UT2A 3GVEA 1UTEA 3H61A 4V0WA 2GJUA 2O8AA 1U32A 1JK7A 1S95A 4I5LC 3RQZA 3V4YA 4B2OA 5J28A 1HP1A 2HY1A 4IL1A 2QFRA 3N5UA 2HYOA 4M0VA 2BCDA 4H2IA 1IT6A 4XPNA 3THNA 3DSDA 1II7A 3C9FA 3DW8C 4UWQA 4FBKA 3QFOA 5EQVA 3H68A 4F0ZA 3KBPA 4G9JA 3QG5C 3ZTVA 4ZX2A 1HO5A 1S3LA 3THOB 1QFCA 2NYMC 1OI8A 4IYPC 2R17A 1KBPA 1QHWA 2WDDA 3IB7A 3H63A 1NNWA 3H62B 3P71C 4ORCA 4TUIA 1FJMA 3ICFA 1OIDA 3EGHA 1USHA 5F3WA 3E7AA 3PSOA 1XM7A 5HPEA 3AUZA 4KKZA 4KBPA 1S3NA 4FBWA 3E7BA 5JPFA 4TUGA 2AHDA 4H1YP 2QFPA 4H2GA 5JJTA 5DNYA 3JYFA 3QFMA 4V0XA 2WDCA 2DFJA 3FGAC 1S8EA 2NXFA 4O43A 5B8IA 1W24A 2USHA 2HYPA 2IE3C 2O8GA 1S3MA 1M63A 4H2BA 4MOYA 2WDFA 2KKNA
chains in the Genus database with same CATH superfamily
4J6OA 3AV0A 2NYLC 3LL8A 3DSCA 1G5BA 2ZBMA 4O4KA 3K7VC 4ORBA 1V73A 4ZVZA 2Q8UA 1T71A 4I5NC 3H67A 1SU1A 2CV9A 2ZOAA 2WDEA 3EGGA 5C1VA 1S70A 4V0VA 4DT2A 4UT3A 2BQ8X 5IOHA 4JA7A 4LTYA 2BDXA 4LU9A 2Z72A 2YVTA 4ORAA 3T1IA 4O24A 5INBA 4FCXA 1OIEA 5GTUA 2IAEC 3C5WC 3IVDA 1T70A 2P6BA 1WARA 5JPEA 3QFNA 3H66A 2Z06A 3QFKA 4UT3B 2XMOA 1Z2XA 3H60A 3PSNA 3RL5A 3H69A 4DHLA 3IVEA 3TGHA 1MF8A 2IE4C 2JOGA 4Q7FA 4MP0A 3RL3A 1UF3A 2Z1AA 4FBQA 3ZU0A 4DSYA 3H64A 1TCOA 2DXLA 4H2FA 4JA9A 2YEQA 3HVQA 3RL4A 3K7WC 4WWLA 3IB8A 4O5GA 1WAO1 1XZWA 2NPPC 1AUIA 4MOVA 2QJCA 4LACC 4H1SA 4NZVA 3CK2A 1HPUA 4YKEA 1Z2WA 2A22A 4HD0A 4OR9A 4UT2A 3GVEA 1UTEA 3H61A 4V0WA 2GJUA 2O8AA 1U32A 1JK7A 1S95A 4I5LC 3RQZA 3V4YA 4B2OA 5J28A 1HP1A 2HY1A 4IL1A 2QFRA 3N5UA 2HYOA 4M0VA 2BCDA 4H2IA 1IT6A 4XPNA 3THNA 3DSDA 1II7A 3C9FA 3FLOA 3DW8C 4UWQA 4FBKA 3QFOA 5EQVA 3H68A 4F0ZA 3KBPA 4G9JA 3QG5C 3ZTVA 4ZX2A 1HO5A 1S3LA 3THOB 1QFCA 2NYMC 1OI8A 4IYPC 2R17A 1KBPA 1QHWA 2WDDA 2DXNA 3H63A 1NNWA 3H62B 3IB7A 3P71C 4ORCA 1FJMA 3ICFA 4TUIA 1OIDA 3EGHA 1USHA 5F3WA 3E7AA 3PSOA 1XM7A 5HPEA 3AUZA 4KKZA 4KBPA 1S3NA 4FBWA 3E7BA 5JPFA 4TUGA 2AHDA 4H1YP 2QFPA 4H2GA 5JJTA 5DNYA 3JYFA 3QFMA 4V0XA 2WDCA 2DFJA 2ZO9B 1S8EA 3FGAC 2NXFA 4O43A 5B8IA 3E0JA 1W24A 3D03A 2USHA 2O8GA 2HYPA 2IE3C 1S3MA 1M63A 4H2BA 4MOYA 2WDFA 2KKNA
chains in the Genus database with same CATH topology
4J6OA 3AV0A 2NYLC 3LL8A 3DSCA 1G5BA 2ZBMA 4O4KA 3K7VC 4ORBA 1V73A 4ZVZA 2Q8UA 1T71A 4I5NC 3H67A 1SU1A 2CV9A 2ZOAA 2WDEA 3EGGA 5C1VA 1S70A 4V0VA 4DT2A 4UT3A 2BQ8X 5IOHA 4JA7A 4LTYA 2BDXA 4LU9A 2Z72A 2YVTA 4ORAA 3T1IA 4O24A 5INBA 4FCXA 1OIEA 5GTUA 2IAEC 3C5WC 3IVDA 1T70A 2P6BA 1WARA 5JPEA 3QFNA 3H66A 2Z06A 3QFKA 4UT3B 2XMOA 1Z2XA 3H60A 3PSNA 3RL5A 3H69A 4DHLA 3IVEA 3TGHA 1MF8A 2IE4C 2JOGA 4Q7FA 4MP0A 3RL3A 1UF3A 2Z1AA 4FBQA 3ZU0A 4DSYA 3H64A 1TCOA 2DXLA 4H2FA 4JA9A 2YEQA 3HVQA 3RL4A 3K7WC 4WWLA 3IB8A 4O5GA 1WAO1 1XZWA 2NPPC 1AUIA 4MOVA 2QJCA 4LACC 4H1SA 4NZVA 3CK2A 1HPUA 4YKEA 1Z2WA 2A22A 4HD0A 4OR9A 4UT2A 3GVEA 1UTEA 3H61A 4V0WA 2GJUA 2O8AA 1U32A 1JK7A 1S95A 4I5LC 3RQZA 3V4YA 4B2OA 5J28A 1HP1A 2HY1A 4IL1A 2QFRA 3N5UA 2HYOA 4M0VA 2BCDA 4H2IA 1IT6A 4XPNA 3THNA 3DSDA 1II7A 3C9FA 3FLOA 3DW8C 4UWQA 4FBKA 3QFOA 5EQVA 3H68A 4F0ZA 3KBPA 4G9JA 3QG5C 3ZTVA 4ZX2A 1HO5A 1S3LA 3THOB 1QFCA 2NYMC 1OI8A 4IYPC 2R17A 1KBPA 1QHWA 2WDDA 2DXNA 3H63A 1NNWA 3H62B 3IB7A 3P71C 4ORCA 1FJMA 3ICFA 4TUIA 1OIDA 3EGHA 1USHA 5F3WA 3E7AA 3PSOA 1XM7A 5HPEA 3AUZA 4KKZA 4KBPA 1S3NA 4FBWA 3E7BA 5JPFA 4TUGA 2AHDA 4H1YP 2QFPA 4H2GA 5JJTA 5DNYA 3JYFA 3QFMA 4V0XA 2WDCA 2DFJA 2ZO9B 1S8EA 3FGAC 2NXFA 4O43A 5B8IA 3E0JA 1W24A 3D03A 2USHA 2O8GA 2HYPA 2IE3C 1S3MA 1M63A 4H2BA 4MOYA 2WDFA 2KKNA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4J6O A;  3AV0 A;  2NYL C;  3LL8 A;  3DSC A;  1G5B A;  2ZBM A;  4O4K A;  3K7V C;  4ORB A;  1V73 A;  4ZVZ A;  2Q8U A;  1T71 A;  4I5N C;  3H67 A;  1SU1 A;  2CV9 A;  2WDE A;  3EGG A;  5C1V A;  1S70 A;  4V0V A;  4DT2 A;  4UT3 A;  2BQ8 X;  5IOH A;  4JA7 A;  4LTY A;  2BDX A;  4LU9 A;  2Z72 A;  2YVT A;  4ORA A;  3T1I A;  4O24 A;  5INB A;  4FCX A;  1OIE A;  5GTU A;  2IAE C;  3C5W C;  3IVD A;  1T70 A;  2P6B A;  1WAR A;  5JPE A;  3QFN A;  3H66 A;  2Z06 A;  3QFK A;  4UT3 B;  2XMO A;  1Z2X A;  3H60 A;  3PSN A;  3RL5 A;  3H69 A;  4DHL A;  3IVE A;  3TGH A;  1MF8 A;  2IE4 C;  2JOG A;  4Q7F A;  4MP0 A;  3RL3 A;  1UF3 A;  2Z1A A;  4FBQ A;  3ZU0 A;  4DSY A;  3H64 A;  1TCO A;  4H2F A;  4JA9 A;  3HVQ A;  3RL4 A;  3K7W C;  4WWL A;  3IB8 A;  4O5G A;  1WAO 1;  1XZW A;  2NPP C;  1AUI A;  4MOV A;  2QJC A;  4LAC C;  4H1S A;  4NZV A;  3CK2 A;  1HPU A;  4YKE A;  1Z2W A;  2A22 A;  4HD0 A;  4OR9 A;  4UT2 A;  3GVE A;  1UTE A;  3H61 A;  4V0W A;  2GJU A;  2O8A A;  1U32 A;  1JK7 A;  1S95 A;  4I5L C;  3RQZ A;  3V4Y A;  4B2O A;  5J28 A;  1HP1 A;  2HY1 A;  4IL1 A;  2QFR A;  3N5U A;  2HYO A;  4M0V A;  2BCD A;  4H2I A;  1IT6 A;  4XPN A;  3THN A;  3DSD A;  1II7 A;  3C9F A;  3DW8 C;  4UWQ A;  4FBK A;  3QFO A;  5EQV A;  3H68 A;  4F0Z A;  3KBP A;  4G9J A;  3QG5 C;  3ZTV A;  4ZX2 A;  1HO5 A;  1S3L A;  3THO B;  1QFC A;  2NYM C;  1OI8 A;  4IYP C;  2R17 A;  1KBP A;  1QHW A;  2WDD A;  3IB7 A;  3H63 A;  1NNW A;  3H62 B;  3P71 C;  4ORC A;  4TUI A;  1FJM A;  3ICF A;  1OID A;  3EGH A;  1USH A;  5F3W A;  3E7A A;  3PSO A;  1XM7 A;  5HPE A;  3AUZ A;  4KKZ A;  4KBP A;  1S3N A;  4FBW A;  3E7B A;  5JPF A;  4TUG A;  2AHD A;  4H1Y P;  2QFP A;  4H2G A;  5JJT A;  5DNY A;  3JYF A;  3QFM A;  4V0X A;  2WDC A;  2DFJ A;  3FGA C;  1S8E A;  2NXF A;  4O43 A;  5B8I A;  1W24 A;  2USH A;  2HYP A;  2IE3 C;  2O8G A;  1S3M A;  1M63 A;  4H2B A;  4MOY A;  2WDF A;  2KKN A; 
#chains in the Genus database with same CATH topology
 4J6O A;  3AV0 A;  2NYL C;  3LL8 A;  3DSC A;  1G5B A;  2ZBM A;  4O4K A;  3K7V C;  4ORB A;  1V73 A;  4ZVZ A;  2Q8U A;  1T71 A;  4I5N C;  3H67 A;  1SU1 A;  2CV9 A;  2ZOA A;  2WDE A;  3EGG A;  5C1V A;  1S70 A;  4V0V A;  4DT2 A;  4UT3 A;  2BQ8 X;  5IOH A;  4JA7 A;  4LTY A;  2BDX A;  4LU9 A;  2Z72 A;  2YVT A;  4ORA A;  3T1I A;  4O24 A;  5INB A;  4FCX A;  1OIE A;  5GTU A;  2IAE C;  3C5W C;  3IVD A;  1T70 A;  2P6B A;  1WAR A;  5JPE A;  3QFN A;  3H66 A;  2Z06 A;  3QFK A;  4UT3 B;  2XMO A;  1Z2X A;  3H60 A;  3PSN A;  3RL5 A;  3H69 A;  4DHL A;  3IVE A;  3TGH A;  1MF8 A;  2IE4 C;  2JOG A;  4Q7F A;  4MP0 A;  3RL3 A;  1UF3 A;  2Z1A A;  4FBQ A;  3ZU0 A;  4DSY A;  3H64 A;  1TCO A;  2DXL A;  4H2F A;  4JA9 A;  2YEQ A;  3HVQ A;  3RL4 A;  3K7W C;  4WWL A;  3IB8 A;  4O5G A;  1WAO 1;  1XZW A;  2NPP C;  1AUI A;  4MOV A;  2QJC A;  4LAC C;  4H1S A;  4NZV A;  3CK2 A;  1HPU A;  4YKE A;  1Z2W A;  2A22 A;  4HD0 A;  4OR9 A;  4UT2 A;  3GVE A;  1UTE A;  3H61 A;  4V0W A;  2GJU A;  2O8A A;  1U32 A;  1JK7 A;  1S95 A;  4I5L C;  3RQZ A;  3V4Y A;  4B2O A;  5J28 A;  1HP1 A;  2HY1 A;  4IL1 A;  2QFR A;  3N5U A;  2HYO A;  4M0V A;  2BCD A;  4H2I A;  1IT6 A;  4XPN A;  3THN A;  3DSD A;  1II7 A;  3C9F A;  3FLO A;  3DW8 C;  4UWQ A;  4FBK A;  3QFO A;  5EQV A;  3H68 A;  4F0Z A;  3KBP A;  4G9J A;  3QG5 C;  3ZTV A;  4ZX2 A;  1HO5 A;  1S3L A;  3THO B;  1QFC A;  2NYM C;  1OI8 A;  4IYP C;  2R17 A;  1KBP A;  1QHW A;  2WDD A;  2DXN A;  3H63 A;  1NNW A;  3H62 B;  3IB7 A;  3P71 C;  4ORC A;  1FJM A;  3ICF A;  4TUI A;  1OID A;  3EGH A;  1USH A;  5F3W A;  3E7A A;  3PSO A;  1XM7 A;  5HPE A;  3AUZ A;  4KKZ A;  4KBP A;  1S3N A;  4FBW A;  3E7B A;  5JPF A;  4TUG A;  2AHD A;  4H1Y P;  2QFP A;  4H2G A;  5JJT A;  5DNY A;  3JYF A;  3QFM A;  4V0X A;  2WDC A;  2DFJ A;  2ZO9 B;  1S8E A;  3FGA C;  2NXF A;  4O43 A;  5B8I A;  3E0J A;  1W24 A;  3D03 A;  2USH A;  2O8G A;  2HYP A;  2IE3 C;  1S3M A;  1M63 A;  4H2B A;  4MOY A;  2WDF A;  2KKN A; 
#chains in the Genus database with same CATH homology
 4J6O A;  3AV0 A;  2NYL C;  3LL8 A;  3DSC A;  1G5B A;  2ZBM A;  4O4K A;  3K7V C;  4ORB A;  1V73 A;  4ZVZ A;  2Q8U A;  1T71 A;  4I5N C;  3H67 A;  1SU1 A;  2CV9 A;  2ZOA A;  2WDE A;  3EGG A;  5C1V A;  1S70 A;  4V0V A;  4DT2 A;  4UT3 A;  2BQ8 X;  5IOH A;  4JA7 A;  4LTY A;  2BDX A;  4LU9 A;  2Z72 A;  2YVT A;  4ORA A;  3T1I A;  4O24 A;  5INB A;  4FCX A;  1OIE A;  5GTU A;  2IAE C;  3C5W C;  3IVD A;  1T70 A;  2P6B A;  1WAR A;  5JPE A;  3QFN A;  3H66 A;  2Z06 A;  3QFK A;  4UT3 B;  2XMO A;  1Z2X A;  3H60 A;  3PSN A;  3RL5 A;  3H69 A;  4DHL A;  3IVE A;  3TGH A;  1MF8 A;  2IE4 C;  2JOG A;  4Q7F A;  4MP0 A;  3RL3 A;  1UF3 A;  2Z1A A;  4FBQ A;  3ZU0 A;  4DSY A;  3H64 A;  1TCO A;  2DXL A;  4H2F A;  4JA9 A;  2YEQ A;  3HVQ A;  3RL4 A;  3K7W C;  4WWL A;  3IB8 A;  4O5G A;  1WAO 1;  1XZW A;  2NPP C;  1AUI A;  4MOV A;  2QJC A;  4LAC C;  4H1S A;  4NZV A;  3CK2 A;  1HPU A;  4YKE A;  1Z2W A;  2A22 A;  4HD0 A;  4OR9 A;  4UT2 A;  3GVE A;  1UTE A;  3H61 A;  4V0W A;  2GJU A;  2O8A A;  1U32 A;  1JK7 A;  1S95 A;  4I5L C;  3RQZ A;  3V4Y A;  4B2O A;  5J28 A;  1HP1 A;  2HY1 A;  4IL1 A;  2QFR A;  3N5U A;  2HYO A;  4M0V A;  2BCD A;  4H2I A;  1IT6 A;  4XPN A;  3THN A;  3DSD A;  1II7 A;  3C9F A;  3FLO A;  3DW8 C;  4UWQ A;  4FBK A;  3QFO A;  5EQV A;  3H68 A;  4F0Z A;  3KBP A;  4G9J A;  3QG5 C;  3ZTV A;  4ZX2 A;  1HO5 A;  1S3L A;  3THO B;  1QFC A;  2NYM C;  1OI8 A;  4IYP C;  2R17 A;  1KBP A;  1QHW A;  2WDD A;  2DXN A;  3H63 A;  1NNW A;  3H62 B;  3IB7 A;  3P71 C;  4ORC A;  1FJM A;  3ICF A;  4TUI A;  1OID A;  3EGH A;  1USH A;  5F3W A;  3E7A A;  3PSO A;  1XM7 A;  5HPE A;  3AUZ A;  4KKZ A;  4KBP A;  1S3N A;  4FBW A;  3E7B A;  5JPF A;  4TUG A;  2AHD A;  4H1Y P;  2QFP A;  4H2G A;  5JJT A;  5DNY A;  3JYF A;  3QFM A;  4V0X A;  2WDC A;  2DFJ A;  2ZO9 B;  1S8E A;  3FGA C;  2NXF A;  4O43 A;  5B8I A;  3E0J A;  1W24 A;  3D03 A;  2USH A;  2O8G A;  2HYP A;  2IE3 C;  1S3M A;  1M63 A;  4H2B A;  4MOY A;  2WDF A;  2KKN A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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