5GTUA

Structural and mechanistic insights into regulation of the retromer coat by tbc1d5
Total Genus 49
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
49
sequence length
186
structure length
186
Chain Sequence
MAGHRLVLVLGDLHIPHRCNSLPAKFKKLLVPGKIQHILCTGNLCTKESYDYLKTLAGDVHIVRGDFDENLNYPEQKVVTVGQFKIGLIHGHQVIPWGDMASLALLQRQFDVDILISGHTHKFEAFEHENKFYINPGSATGAYNALETNIIPSFVLMDIQASTVVTYVYQLIGDDVKVERIEYKKP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural and mechanistic insights into regulation of the retromer coat by TBC1d5
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Vacuolar protein sorting-associated protein 29
total genus 49
structure length 186
sequence length 186
ec nomenclature
pdb deposition date 2016-08-23
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 5gtuA00
3C5WC 4UT3A 1FJMA 1S95A 1M63A 2NPPC 4M0VA 4F0ZA 4G9JA 3IVDA 4O24A 3EGGA 4DT2A 3THNA 2HYOA 5IOHA 4TUGA 4MOYA 1UF3A 1KBPA 1V73A 1HO5A 4FBQA 5JPFA 4I5NC 2R17A 4JA7A 4UWQA 5JPEA 3AUZA 2WDFA 4Q7FA 2BQ8X 4MOVA 5DNYA 1S3NA 1HP1A 3IB8A 3FGAC 3H61A 2IE3C 3AV0A 3QFNA 4XPNA 1IT6A 2P6BA 1JK7A 4H2FA 4H1YP 4H1SA 3ICFA 1TCOA 1NNWA 3IVEA 4HD0A 5F3WA 4OR9A 3JYFA 1S70A 2Z72A 5J28A 1G5BA 2KKNA 5JJTA 3GVEA 3RL5A 4FBWA 3RQZA 5B8IA 2JOGA 3DSCA 3H68A 3KBPA 1SU1A 3CK2A 5HPEA 2A22A 3ZTVA 1QFCA 2AHDA 4FCXA 1OI8A 4O4KA 4YKEA 3ZU0A 4O5GA 4V0VA 3DSDA 4I5LC 2USHA 4KKZA 1S3LA 2IE4C 3QFKA 3H62B 4FBKA 1WARA 1OIEA 1Z2XA 4ORAA 3C9FA 4LACC 4UT2A 3THOB 2CV9A 3H67A 1HPUA 3PSNA 5INBA 3H66A 4UT3B 3E7BA 3T1IA 3K7VC 2GJUA 1S8EA 2WDDA 4DHLA 4V0WA 4TUIA 3H63A 3HVQA 1MF8A 3PSOA 2WDEA 4J6OA 2ZBMA 4H2BA 3H60A 4ORCA 4NZVA 1T71A 1U32A 3QFMA 3DW8C 4B2OA 2Z06A 3LL8A 3H69A 4H2GA 1XM7A 2HY1A 4H2IA 5C1VA 2O8AA 1T70A 2NYMC 2BDXA 3RL4A 3TGHA 1OIDA 3N5UA 1QHWA 4V0XA 4DSYA 3K7WC 4ZVZA 2NXFA 4O43A 3V4YA 3IB7A 3RL3A 2QJCA 3P71C 1USHA 4LU9A 4LTYA 1W24A 3E7AA 4WWLA 2DFJA 1AUIA 2Q8UA 4IL1A 1UTEA 1S3MA 5GTUA 3EGHA 1Z2WA 4ORBA 5EQVA 2BCDA 2WDCA 2IAEC 1XZWA 4MP0A 2HYPA 3QG5C 2XMOA 4JA9A 2YVTA 1II7A 3H64A 4KBPA 4ZX2A 1WAO1 3QFOA 2NYLC 2QFRA 4IYPC 2O8GA 2Z1AA 2QFPA
chains in the Genus database with same CATH superfamily
3C5WC 4UT3A 1FJMA 1S95A 3E0JA 1M63A 2NPPC 4M0VA 4F0ZA 4G9JA 3IVDA 4O24A 3EGGA 4DT2A 3THNA 2HYOA 5IOHA 4TUGA 4MOYA 1UF3A 1KBPA 1V73A 1HO5A 4FBQA 5JPFA 4I5NC 2R17A 2DXLA 4JA7A 4UWQA 5JPEA 3AUZA 2WDFA 4Q7FA 2BQ8X 4MOVA 5DNYA 1S3NA 1HP1A 3IB8A 3FGAC 3H61A 2IE3C 3AV0A 3QFNA 4XPNA 1IT6A 2P6BA 1JK7A 4H2FA 4H1YP 4H1SA 3ICFA 1TCOA 1NNWA 3IVEA 4HD0A 5F3WA 4OR9A 3JYFA 1S70A 2Z72A 5J28A 1G5BA 2KKNA 5JJTA 3GVEA 3RL5A 4FBWA 3RQZA 5B8IA 2JOGA 3DSCA 3H68A 3KBPA 2DXNA 1SU1A 3DSDA 3CK2A 5HPEA 2A22A 3ZTVA 1QFCA 2AHDA 4FCXA 1OI8A 4O4KA 4YKEA 3ZU0A 3D03A 4O5GA 4V0VA 4I5LC 2USHA 4KKZA 1S3LA 2IE4C 3QFKA 3H62B 4FBKA 1WARA 1OIEA 1Z2XA 4ORAA 3C9FA 4LACC 4UT2A 3THOB 2CV9A 3H67A 1HPUA 2YEQA 3PSNA 3H66A 5INBA 4UT3B 3E7BA 3T1IA 3K7VC 2ZOAA 2GJUA 1S8EA 2WDDA 4DHLA 4V0WA 4TUIA 3H63A 3HVQA 1MF8A 3PSOA 2WDEA 4J6OA 2ZBMA 4H2BA 3H60A 4ORCA 4NZVA 1T71A 1U32A 3QFMA 3DW8C 4B2OA 2Z06A 3LL8A 3H69A 4H2GA 1XM7A 2HY1A 4H2IA 5C1VA 2O8AA 1T70A 2NYMC 2BDXA 3RL4A 3TGHA 1OIDA 3N5UA 1QHWA 4V0XA 4DSYA 3K7WC 4ZVZA 2NXFA 4O43A 3V4YA 3IB7A 3RL3A 2QJCA 3P71C 1USHA 3FLOA 4LU9A 4LTYA 1W24A 3E7AA 4WWLA 2DFJA 1AUIA 2Q8UA 4IL1A 1UTEA 1S3MA 5GTUA 3EGHA 1Z2WA 4ORBA 5EQVA 2BCDA 2WDCA 2IAEC 1XZWA 4MP0A 2HYPA 3QG5C 2XMOA 4JA9A 2YVTA 1II7A 3H64A 2ZO9B 4KBPA 4ZX2A 1WAO1 3QFOA 2NYLC 2QFRA 4IYPC 2O8GA 2Z1AA 2QFPA
chains in the Genus database with same CATH topology
3C5WC 4UT3A 1FJMA 1S95A 3E0JA 1M63A 2NPPC 4M0VA 4F0ZA 4G9JA 3IVDA 4O24A 3EGGA 4DT2A 3THNA 2HYOA 5IOHA 4TUGA 4MOYA 1UF3A 1KBPA 1V73A 1HO5A 4FBQA 5JPFA 4I5NC 2R17A 2DXLA 4JA7A 4UWQA 5JPEA 3AUZA 2WDFA 4Q7FA 2BQ8X 4MOVA 5DNYA 1S3NA 1HP1A 3IB8A 3FGAC 3H61A 2IE3C 3AV0A 3QFNA 4XPNA 1IT6A 2P6BA 1JK7A 4H2FA 4H1YP 4H1SA 3ICFA 1TCOA 1NNWA 3IVEA 4HD0A 5F3WA 4OR9A 3JYFA 1S70A 2Z72A 5J28A 1G5BA 2KKNA 5JJTA 3GVEA 3RL5A 4FBWA 3RQZA 5B8IA 2JOGA 3DSCA 3H68A 3KBPA 2DXNA 1SU1A 3DSDA 3CK2A 5HPEA 2A22A 3ZTVA 1QFCA 2AHDA 4FCXA 1OI8A 4O4KA 4YKEA 3ZU0A 3D03A 4O5GA 4V0VA 4I5LC 2USHA 4KKZA 1S3LA 2IE4C 3QFKA 3H62B 4FBKA 1WARA 1OIEA 1Z2XA 4ORAA 3C9FA 4LACC 4UT2A 3THOB 2CV9A 3H67A 1HPUA 2YEQA 3PSNA 3H66A 5INBA 4UT3B 3E7BA 3T1IA 3K7VC 2ZOAA 2GJUA 1S8EA 2WDDA 4DHLA 4V0WA 4TUIA 3H63A 3HVQA 1MF8A 3PSOA 2WDEA 4J6OA 2ZBMA 4H2BA 3H60A 4ORCA 4NZVA 1T71A 1U32A 3QFMA 3DW8C 4B2OA 2Z06A 3LL8A 3H69A 4H2GA 1XM7A 2HY1A 4H2IA 5C1VA 2O8AA 1T70A 2NYMC 2BDXA 3RL4A 3TGHA 1OIDA 3N5UA 1QHWA 4V0XA 4DSYA 3K7WC 4ZVZA 2NXFA 4O43A 3V4YA 3IB7A 3RL3A 2QJCA 3P71C 1USHA 3FLOA 4LU9A 4LTYA 1W24A 3E7AA 4WWLA 2DFJA 1AUIA 2Q8UA 4IL1A 1UTEA 1S3MA 5GTUA 3EGHA 1Z2WA 4ORBA 5EQVA 2BCDA 2WDCA 2IAEC 1XZWA 4MP0A 2HYPA 3QG5C 2XMOA 4JA9A 2YVTA 1II7A 3H64A 2ZO9B 4KBPA 4ZX2A 1WAO1 3QFOA 2NYLC 2QFRA 4IYPC 2O8GA 2Z1AA 2QFPA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3C5W C;  4UT3 A;  1FJM A;  1S95 A;  1M63 A;  2NPP C;  4M0V A;  4F0Z A;  4G9J A;  3IVD A;  4O24 A;  3EGG A;  4DT2 A;  3THN A;  2HYO A;  5IOH A;  4TUG A;  4MOY A;  1UF3 A;  1KBP A;  1V73 A;  1HO5 A;  4FBQ A;  5JPF A;  4I5N C;  2R17 A;  4JA7 A;  4UWQ A;  5JPE A;  3AUZ A;  2WDF A;  4Q7F A;  2BQ8 X;  4MOV A;  5DNY A;  1S3N A;  1HP1 A;  3IB8 A;  3FGA C;  3H61 A;  2IE3 C;  3AV0 A;  3QFN A;  4XPN A;  1IT6 A;  2P6B A;  1JK7 A;  4H2F A;  4H1Y P;  4H1S A;  3ICF A;  1TCO A;  1NNW A;  3IVE A;  4HD0 A;  5F3W A;  4OR9 A;  3JYF A;  1S70 A;  2Z72 A;  5J28 A;  1G5B A;  2KKN A;  5JJT A;  3GVE A;  3RL5 A;  4FBW A;  3RQZ A;  5B8I A;  2JOG A;  3DSC A;  3H68 A;  3KBP A;  1SU1 A;  3CK2 A;  5HPE A;  2A22 A;  3ZTV A;  1QFC A;  2AHD A;  4FCX A;  1OI8 A;  4O4K A;  4YKE A;  3ZU0 A;  4O5G A;  4V0V A;  3DSD A;  4I5L C;  2USH A;  4KKZ A;  1S3L A;  2IE4 C;  3QFK A;  3H62 B;  4FBK A;  1WAR A;  1OIE A;  1Z2X A;  4ORA A;  3C9F A;  4LAC C;  4UT2 A;  3THO B;  2CV9 A;  3H67 A;  1HPU A;  3PSN A;  5INB A;  3H66 A;  4UT3 B;  3E7B A;  3T1I A;  3K7V C;  2GJU A;  1S8E A;  2WDD A;  4DHL A;  4V0W A;  4TUI A;  3H63 A;  3HVQ A;  1MF8 A;  3PSO A;  2WDE A;  4J6O A;  2ZBM A;  4H2B A;  3H60 A;  4ORC A;  4NZV A;  1T71 A;  1U32 A;  3QFM A;  3DW8 C;  4B2O A;  2Z06 A;  3LL8 A;  3H69 A;  4H2G A;  1XM7 A;  2HY1 A;  4H2I A;  5C1V A;  2O8A A;  1T70 A;  2NYM C;  2BDX A;  3RL4 A;  3TGH A;  1OID A;  3N5U A;  1QHW A;  4V0X A;  4DSY A;  3K7W C;  4ZVZ A;  2NXF A;  4O43 A;  3V4Y A;  3IB7 A;  3RL3 A;  2QJC A;  3P71 C;  1USH A;  4LU9 A;  4LTY A;  1W24 A;  3E7A A;  4WWL A;  2DFJ A;  1AUI A;  2Q8U A;  4IL1 A;  1UTE A;  1S3M A;  5GTU A;  3EGH A;  1Z2W A;  4ORB A;  5EQV A;  2BCD A;  2WDC A;  2IAE C;  1XZW A;  4MP0 A;  2HYP A;  3QG5 C;  2XMO A;  4JA9 A;  2YVT A;  1II7 A;  3H64 A;  4KBP A;  4ZX2 A;  1WAO 1;  3QFO A;  2NYL C;  2QFR A;  4IYP C;  2O8G A;  2Z1A A;  2QFP A; 
#chains in the Genus database with same CATH topology
 3C5W C;  4UT3 A;  1FJM A;  1S95 A;  3E0J A;  1M63 A;  2NPP C;  4M0V A;  4F0Z A;  4G9J A;  3IVD A;  4O24 A;  3EGG A;  4DT2 A;  3THN A;  2HYO A;  5IOH A;  4TUG A;  4MOY A;  1UF3 A;  1KBP A;  1V73 A;  1HO5 A;  4FBQ A;  5JPF A;  4I5N C;  2R17 A;  2DXL A;  4JA7 A;  4UWQ A;  5JPE A;  3AUZ A;  2WDF A;  4Q7F A;  2BQ8 X;  4MOV A;  5DNY A;  1S3N A;  1HP1 A;  3IB8 A;  3FGA C;  3H61 A;  2IE3 C;  3AV0 A;  3QFN A;  4XPN A;  1IT6 A;  2P6B A;  1JK7 A;  4H2F A;  4H1Y P;  4H1S A;  3ICF A;  1TCO A;  1NNW A;  3IVE A;  4HD0 A;  5F3W A;  4OR9 A;  3JYF A;  1S70 A;  2Z72 A;  5J28 A;  1G5B A;  2KKN A;  5JJT A;  3GVE A;  3RL5 A;  4FBW A;  3RQZ A;  5B8I A;  2JOG A;  3DSC A;  3H68 A;  3KBP A;  2DXN A;  1SU1 A;  3DSD A;  3CK2 A;  5HPE A;  2A22 A;  3ZTV A;  1QFC A;  2AHD A;  4FCX A;  1OI8 A;  4O4K A;  4YKE A;  3ZU0 A;  3D03 A;  4O5G A;  4V0V A;  4I5L C;  2USH A;  4KKZ A;  1S3L A;  2IE4 C;  3QFK A;  3H62 B;  4FBK A;  1WAR A;  1OIE A;  1Z2X A;  4ORA A;  3C9F A;  4LAC C;  4UT2 A;  3THO B;  2CV9 A;  3H67 A;  1HPU A;  2YEQ A;  3PSN A;  3H66 A;  5INB A;  4UT3 B;  3E7B A;  3T1I A;  3K7V C;  2ZOA A;  2GJU A;  1S8E A;  2WDD A;  4DHL A;  4V0W A;  4TUI A;  3H63 A;  3HVQ A;  1MF8 A;  3PSO A;  2WDE A;  4J6O A;  2ZBM A;  4H2B A;  3H60 A;  4ORC A;  4NZV A;  1T71 A;  1U32 A;  3QFM A;  3DW8 C;  4B2O A;  2Z06 A;  3LL8 A;  3H69 A;  4H2G A;  1XM7 A;  2HY1 A;  4H2I A;  5C1V A;  2O8A A;  1T70 A;  2NYM C;  2BDX A;  3RL4 A;  3TGH A;  1OID A;  3N5U A;  1QHW A;  4V0X A;  4DSY A;  3K7W C;  4ZVZ A;  2NXF A;  4O43 A;  3V4Y A;  3IB7 A;  3RL3 A;  2QJC A;  3P71 C;  1USH A;  3FLO A;  4LU9 A;  4LTY A;  1W24 A;  3E7A A;  4WWL A;  2DFJ A;  1AUI A;  2Q8U A;  4IL1 A;  1UTE A;  1S3M A;  5GTU A;  3EGH A;  1Z2W A;  4ORB A;  5EQV A;  2BCD A;  2WDC A;  2IAE C;  1XZW A;  4MP0 A;  2HYP A;  3QG5 C;  2XMO A;  4JA9 A;  2YVT A;  1II7 A;  3H64 A;  2ZO9 B;  4KBP A;  4ZX2 A;  1WAO 1;  3QFO A;  2NYL C;  2QFR A;  4IYP C;  2O8G A;  2Z1A A;  2QFP A; 
#chains in the Genus database with same CATH homology
 3C5W C;  4UT3 A;  1FJM A;  1S95 A;  3E0J A;  1M63 A;  2NPP C;  4M0V A;  4F0Z A;  4G9J A;  3IVD A;  4O24 A;  3EGG A;  4DT2 A;  3THN A;  2HYO A;  5IOH A;  4TUG A;  4MOY A;  1UF3 A;  1KBP A;  1V73 A;  1HO5 A;  4FBQ A;  5JPF A;  4I5N C;  2R17 A;  2DXL A;  4JA7 A;  4UWQ A;  5JPE A;  3AUZ A;  2WDF A;  4Q7F A;  2BQ8 X;  4MOV A;  5DNY A;  1S3N A;  1HP1 A;  3IB8 A;  3FGA C;  3H61 A;  2IE3 C;  3AV0 A;  3QFN A;  4XPN A;  1IT6 A;  2P6B A;  1JK7 A;  4H2F A;  4H1Y P;  4H1S A;  3ICF A;  1TCO A;  1NNW A;  3IVE A;  4HD0 A;  5F3W A;  4OR9 A;  3JYF A;  1S70 A;  2Z72 A;  5J28 A;  1G5B A;  2KKN A;  5JJT A;  3GVE A;  3RL5 A;  4FBW A;  3RQZ A;  5B8I A;  2JOG A;  3DSC A;  3H68 A;  3KBP A;  2DXN A;  1SU1 A;  3DSD A;  3CK2 A;  5HPE A;  2A22 A;  3ZTV A;  1QFC A;  2AHD A;  4FCX A;  1OI8 A;  4O4K A;  4YKE A;  3ZU0 A;  3D03 A;  4O5G A;  4V0V A;  4I5L C;  2USH A;  4KKZ A;  1S3L A;  2IE4 C;  3QFK A;  3H62 B;  4FBK A;  1WAR A;  1OIE A;  1Z2X A;  4ORA A;  3C9F A;  4LAC C;  4UT2 A;  3THO B;  2CV9 A;  3H67 A;  1HPU A;  2YEQ A;  3PSN A;  3H66 A;  5INB A;  4UT3 B;  3E7B A;  3T1I A;  3K7V C;  2ZOA A;  2GJU A;  1S8E A;  2WDD A;  4DHL A;  4V0W A;  4TUI A;  3H63 A;  3HVQ A;  1MF8 A;  3PSO A;  2WDE A;  4J6O A;  2ZBM A;  4H2B A;  3H60 A;  4ORC A;  4NZV A;  1T71 A;  1U32 A;  3QFM A;  3DW8 C;  4B2O A;  2Z06 A;  3LL8 A;  3H69 A;  4H2G A;  1XM7 A;  2HY1 A;  4H2I A;  5C1V A;  2O8A A;  1T70 A;  2NYM C;  2BDX A;  3RL4 A;  3TGH A;  1OID A;  3N5U A;  1QHW A;  4V0X A;  4DSY A;  3K7W C;  4ZVZ A;  2NXF A;  4O43 A;  3V4Y A;  3IB7 A;  3RL3 A;  2QJC A;  3P71 C;  1USH A;  3FLO A;  4LU9 A;  4LTY A;  1W24 A;  3E7A A;  4WWL A;  2DFJ A;  1AUI A;  2Q8U A;  4IL1 A;  1UTE A;  1S3M A;  5GTU A;  3EGH A;  1Z2W A;  4ORB A;  5EQV A;  2BCD A;  2WDC A;  2IAE C;  1XZW A;  4MP0 A;  2HYP A;  3QG5 C;  2XMO A;  4JA9 A;  2YVT A;  1II7 A;  3H64 A;  2ZO9 B;  4KBP A;  4ZX2 A;  1WAO 1;  3QFO A;  2NYL C;  2QFR A;  4IYP C;  2O8G A;  2Z1A A;  2QFP A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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