5IOHA

Repoman-pp1a (protein phosphatase 1, alpha isoform) holoenzyme complex
Total Genus 104
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
104
sequence length
293
structure length
293
Chain Sequence
LNLDSIIGRLLEVQGSRPGKNVQLTENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVQGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The Ki-67 and RepoMan mitotic phosphatases assemble via an identical, yet novel mechanism.
pubmed doi rcsb
molecule tags Hydrolase/protein binding
source organism Homo sapiens
molecule keywords Serine/threonine-protein phosphatase PP1-alpha catalytic sub
total genus 104
structure length 293
sequence length 293
chains with identical sequence C
ec nomenclature ec 3.1.3.16: Protein-serine/threonine phosphatase.
pdb deposition date 2016-03-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00149 Metallophos Calcineurin-like phosphoesterase
A PF16891 STPPase_N Serine-threonine protein phosphatase N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 5iohA00
1USHA 3IVEA 4H2GA 3RL3A 1FJMA 1JK7A 4FBQA 4G9JA 3IB8A 4V0XA 4ZVZA 5EQVA 1HPUA 1U32A 4IYPC 2BDXA 4UWQA 2NPPC 2AHDA 4YKEA 3DSDA 4TUIA 2HYPA 3QFNA 4KBPA 2QJCA 4WWLA 4KKZA 4HD0A 3V4YA 2BCDA 3H67A 3K7WC 4MOVA 1MF8A 4UT2A 5JPFA 2P6BA 4IL1A 3RQZA 4DT2A 3RL5A 3GVEA 4M0VA 3HVQA 1S95A 4O4KA 4MP0A 3T1IA 4H2FA 4LTYA 1T71A 4UT3A 5IOHA 4ORBA 3N5UA 4O24A 3H62B 1IT6A 2Z72A 3K7VC 2A22A 5C1VA 2WDDA 2O8GA 3KBPA 4JA9A 2WDFA 3IB7A 1OIDA 3ICFA 2KKNA 2Z06A 3H63A 1S3LA 2DFJA 3H69A 1W24A 3ZU0A 4B2OA 5INBA 3H61A 1S3NA 1OI8A 1S3MA 3E7BA 4I5NC 5J28A 4O5GA 4NZVA 1WAO1 1NNWA 1SU1A 4H1YP 1HP1A 1XM7A 3H66A 5JPEA 4H1SA 3P71C 1XZWA 3C9FA 1G5BA 3CK2A 1S70A 2ZBMA 1WARA 2O8AA 3QG5C 1QFCA 2R17A 3C5WC 1TCOA 3EGGA 3PSNA 3AUZA 3AV0A 2NYMC 4XPNA 2IE3C 2JOGA 2CV9A 3H60A 2XMOA 4H2IA 4ORCA 3TGHA 1Z2XA 2BQ8X 4I5LC 3H64A 4FBWA 4V0WA 4Q7FA 4DHLA 3DSCA 1S8EA 1HO5A 4H2BA 2GJUA 4DSYA 3EGHA 1QHWA 4J6OA 4LACC 2NYLC 1V73A 5HPEA 2Q8UA 5B8IA 3E7AA 4FCXA 3RL4A 4ORAA 4ZX2A 3QFKA 3IVDA 2HYOA 2WDCA 1T70A 3ZTVA 4MOYA 4FBKA 2QFRA 3THOB 5JJTA 4JA7A 3QFOA 1II7A 1Z2WA 2WDEA 2IAEC 5DNYA 5GTUA 1M63A 2HY1A 1UTEA 3THNA 3PSOA 1KBPA 4LU9A 4UT3B 3DW8C 2USHA 2IE4C 3JYFA 2YVTA 3QFMA 4OR9A 3LL8A 1AUIA 4F0ZA 4V0VA 2QFPA 4O43A 3FGAC 3H68A 1UF3A 1OIEA 4TUGA 2NXFA 5F3WA 2Z1AA
chains in the Genus database with same CATH superfamily
1USHA 3IVEA 4H2GA 3RL3A 1FJMA 1JK7A 4FBQA 4G9JA 3IB8A 4V0XA 4ZVZA 5EQVA 1HPUA 1U32A 4IYPC 2BDXA 4UWQA 2NPPC 2AHDA 4YKEA 3DSDA 4TUIA 2HYPA 3QFNA 4KBPA 2QJCA 4WWLA 4KKZA 4HD0A 3V4YA 2BCDA 3H67A 3K7WC 4MOVA 1MF8A 4UT2A 5JPFA 2P6BA 2ZOAA 4IL1A 3RQZA 4DT2A 3RL5A 3GVEA 4M0VA 3HVQA 1S95A 4O4KA 4MP0A 3T1IA 4H2FA 4LTYA 1T71A 4UT3A 5IOHA 4ORBA 3N5UA 4O24A 3H62B 1IT6A 2Z72A 2ZO9B 3K7VC 2A22A 5C1VA 2WDDA 2O8GA 3KBPA 4JA9A 2WDFA 3IB7A 1OIDA 3ICFA 2KKNA 2Z06A 3H63A 1S3LA 2DFJA 3H69A 1W24A 3ZU0A 4B2OA 5INBA 3H61A 1S3NA 1OI8A 1S3MA 3E7BA 4I5NC 5J28A 4O5GA 4NZVA 1WAO1 1NNWA 1SU1A 2DXNA 4H1YP 1HP1A 1XM7A 3H66A 3FLOA 5JPEA 4H1SA 3P71C 2DXLA 1XZWA 3C9FA 1G5BA 3CK2A 1S70A 2ZBMA 1WARA 2O8AA 3QG5C 1QFCA 2R17A 3C5WC 1TCOA 3EGGA 3PSNA 3AUZA 3AV0A 2NYMC 4XPNA 2IE3C 2JOGA 2CV9A 3E0JA 3H60A 2XMOA 4H2IA 4ORCA 3TGHA 1Z2XA 2BQ8X 4I5LC 3H64A 4FBWA 4V0WA 4Q7FA 4DHLA 3DSCA 1S8EA 1HO5A 4H2BA 2GJUA 4DSYA 3D03A 3EGHA 1QHWA 4J6OA 2YEQA 4LACC 2NYLC 1V73A 5HPEA 2Q8UA 5B8IA 3E7AA 4FCXA 3RL4A 4ORAA 4ZX2A 3QFKA 3IVDA 2HYOA 2WDCA 1T70A 3ZTVA 4MOYA 4FBKA 2QFRA 3THOB 5JJTA 4JA7A 3QFOA 1II7A 1Z2WA 2WDEA 2IAEC 5DNYA 5GTUA 1M63A 2HY1A 1UTEA 3THNA 3PSOA 1KBPA 4LU9A 4UT3B 3DW8C 2USHA 2IE4C 3JYFA 2YVTA 3QFMA 4OR9A 3LL8A 1AUIA 4F0ZA 4V0VA 2QFPA 4O43A 3FGAC 3H68A 1UF3A 1OIEA 4TUGA 2NXFA 5F3WA 2Z1AA
chains in the Genus database with same CATH topology
1USHA 3IVEA 4H2GA 3RL3A 1FJMA 1JK7A 4FBQA 4G9JA 3IB8A 4V0XA 4ZVZA 5EQVA 1HPUA 1U32A 4IYPC 2BDXA 4UWQA 2NPPC 2AHDA 4YKEA 3DSDA 4TUIA 2HYPA 3QFNA 4KBPA 2QJCA 4WWLA 4KKZA 4HD0A 3V4YA 2BCDA 3H67A 3K7WC 4MOVA 1MF8A 4UT2A 5JPFA 2P6BA 2ZOAA 4IL1A 3RQZA 4DT2A 3RL5A 3GVEA 4M0VA 3HVQA 1S95A 4O4KA 4MP0A 3T1IA 4H2FA 4LTYA 1T71A 4UT3A 5IOHA 4ORBA 3N5UA 4O24A 3H62B 1IT6A 2Z72A 2ZO9B 3K7VC 2A22A 5C1VA 2WDDA 2O8GA 3KBPA 4JA9A 2WDFA 3IB7A 1OIDA 3ICFA 2KKNA 2Z06A 3H63A 1S3LA 2DFJA 3H69A 1W24A 3ZU0A 4B2OA 5INBA 3H61A 1S3NA 1OI8A 1S3MA 3E7BA 4I5NC 5J28A 4O5GA 4NZVA 1WAO1 1NNWA 1SU1A 2DXNA 4H1YP 1HP1A 1XM7A 3H66A 3FLOA 5JPEA 4H1SA 3P71C 2DXLA 1XZWA 3C9FA 1G5BA 3CK2A 1S70A 2ZBMA 1WARA 2O8AA 3QG5C 1QFCA 2R17A 3C5WC 1TCOA 3EGGA 3PSNA 3AUZA 3AV0A 2NYMC 4XPNA 2IE3C 2JOGA 2CV9A 3E0JA 3H60A 2XMOA 4H2IA 4ORCA 3TGHA 1Z2XA 2BQ8X 4I5LC 3H64A 4FBWA 4V0WA 4Q7FA 4DHLA 3DSCA 1S8EA 1HO5A 4H2BA 2GJUA 4DSYA 3D03A 3EGHA 1QHWA 4J6OA 2YEQA 4LACC 2NYLC 1V73A 5HPEA 2Q8UA 5B8IA 3E7AA 4FCXA 3RL4A 4ORAA 4ZX2A 3QFKA 3IVDA 2HYOA 2WDCA 1T70A 3ZTVA 4MOYA 4FBKA 2QFRA 3THOB 5JJTA 4JA7A 3QFOA 1II7A 1Z2WA 2WDEA 2IAEC 5DNYA 5GTUA 1M63A 2HY1A 1UTEA 3THNA 3PSOA 1KBPA 4LU9A 4UT3B 3DW8C 2USHA 2IE4C 3JYFA 2YVTA 3QFMA 4OR9A 3LL8A 1AUIA 4F0ZA 4V0VA 2QFPA 4O43A 3FGAC 3H68A 1UF3A 1OIEA 4TUGA 2NXFA 5F3WA 2Z1AA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1USH A;  3IVE A;  4H2G A;  3RL3 A;  1FJM A;  1JK7 A;  4FBQ A;  4G9J A;  3IB8 A;  4V0X A;  4ZVZ A;  5EQV A;  1HPU A;  1U32 A;  4IYP C;  2BDX A;  4UWQ A;  2NPP C;  2AHD A;  4YKE A;  3DSD A;  4TUI A;  2HYP A;  3QFN A;  4KBP A;  2QJC A;  4WWL A;  4KKZ A;  4HD0 A;  3V4Y A;  2BCD A;  3H67 A;  3K7W C;  4MOV A;  1MF8 A;  4UT2 A;  5JPF A;  2P6B A;  4IL1 A;  3RQZ A;  4DT2 A;  3RL5 A;  3GVE A;  4M0V A;  3HVQ A;  1S95 A;  4O4K A;  4MP0 A;  3T1I A;  4H2F A;  4LTY A;  1T71 A;  4UT3 A;  5IOH A;  4ORB A;  3N5U A;  4O24 A;  3H62 B;  1IT6 A;  2Z72 A;  3K7V C;  2A22 A;  5C1V A;  2WDD A;  2O8G A;  3KBP A;  4JA9 A;  2WDF A;  3IB7 A;  1OID A;  3ICF A;  2KKN A;  2Z06 A;  3H63 A;  1S3L A;  2DFJ A;  3H69 A;  1W24 A;  3ZU0 A;  4B2O A;  5INB A;  3H61 A;  1S3N A;  1OI8 A;  1S3M A;  3E7B A;  4I5N C;  5J28 A;  4O5G A;  4NZV A;  1WAO 1;  1NNW A;  1SU1 A;  4H1Y P;  1HP1 A;  1XM7 A;  3H66 A;  5JPE A;  4H1S A;  3P71 C;  1XZW A;  3C9F A;  1G5B A;  3CK2 A;  1S70 A;  2ZBM A;  1WAR A;  2O8A A;  3QG5 C;  1QFC A;  2R17 A;  3C5W C;  1TCO A;  3EGG A;  3PSN A;  3AUZ A;  3AV0 A;  2NYM C;  4XPN A;  2IE3 C;  2JOG A;  2CV9 A;  3H60 A;  2XMO A;  4H2I A;  4ORC A;  3TGH A;  1Z2X A;  2BQ8 X;  4I5L C;  3H64 A;  4FBW A;  4V0W A;  4Q7F A;  4DHL A;  3DSC A;  1S8E A;  1HO5 A;  4H2B A;  2GJU A;  4DSY A;  3EGH A;  1QHW A;  4J6O A;  4LAC C;  2NYL C;  1V73 A;  5HPE A;  2Q8U A;  5B8I A;  3E7A A;  4FCX A;  3RL4 A;  4ORA A;  4ZX2 A;  3QFK A;  3IVD A;  2HYO A;  2WDC A;  1T70 A;  3ZTV A;  4MOY A;  4FBK A;  2QFR A;  3THO B;  5JJT A;  4JA7 A;  3QFO A;  1II7 A;  1Z2W A;  2WDE A;  2IAE C;  5DNY A;  5GTU A;  1M63 A;  2HY1 A;  1UTE A;  3THN A;  3PSO A;  1KBP A;  4LU9 A;  4UT3 B;  3DW8 C;  2USH A;  2IE4 C;  3JYF A;  2YVT A;  3QFM A;  4OR9 A;  3LL8 A;  1AUI A;  4F0Z A;  4V0V A;  2QFP A;  4O43 A;  3FGA C;  3H68 A;  1UF3 A;  1OIE A;  4TUG A;  2NXF A;  5F3W A;  2Z1A A; 
#chains in the Genus database with same CATH topology
 1USH A;  3IVE A;  4H2G A;  3RL3 A;  1FJM A;  1JK7 A;  4FBQ A;  4G9J A;  3IB8 A;  4V0X A;  4ZVZ A;  5EQV A;  1HPU A;  1U32 A;  4IYP C;  2BDX A;  4UWQ A;  2NPP C;  2AHD A;  4YKE A;  3DSD A;  4TUI A;  2HYP A;  3QFN A;  4KBP A;  2QJC A;  4WWL A;  4KKZ A;  4HD0 A;  3V4Y A;  2BCD A;  3H67 A;  3K7W C;  4MOV A;  1MF8 A;  4UT2 A;  5JPF A;  2P6B A;  2ZOA A;  4IL1 A;  3RQZ A;  4DT2 A;  3RL5 A;  3GVE A;  4M0V A;  3HVQ A;  1S95 A;  4O4K A;  4MP0 A;  3T1I A;  4H2F A;  4LTY A;  1T71 A;  4UT3 A;  5IOH A;  4ORB A;  3N5U A;  4O24 A;  3H62 B;  1IT6 A;  2Z72 A;  2ZO9 B;  3K7V C;  2A22 A;  5C1V A;  2WDD A;  2O8G A;  3KBP A;  4JA9 A;  2WDF A;  3IB7 A;  1OID A;  3ICF A;  2KKN A;  2Z06 A;  3H63 A;  1S3L A;  2DFJ A;  3H69 A;  1W24 A;  3ZU0 A;  4B2O A;  5INB A;  3H61 A;  1S3N A;  1OI8 A;  1S3M A;  3E7B A;  4I5N C;  5J28 A;  4O5G A;  4NZV A;  1WAO 1;  1NNW A;  1SU1 A;  2DXN A;  4H1Y P;  1HP1 A;  1XM7 A;  3H66 A;  3FLO A;  5JPE A;  4H1S A;  3P71 C;  2DXL A;  1XZW A;  3C9F A;  1G5B A;  3CK2 A;  1S70 A;  2ZBM A;  1WAR A;  2O8A A;  3QG5 C;  1QFC A;  2R17 A;  3C5W C;  1TCO A;  3EGG A;  3PSN A;  3AUZ A;  3AV0 A;  2NYM C;  4XPN A;  2IE3 C;  2JOG A;  2CV9 A;  3E0J A;  3H60 A;  2XMO A;  4H2I A;  4ORC A;  3TGH A;  1Z2X A;  2BQ8 X;  4I5L C;  3H64 A;  4FBW A;  4V0W A;  4Q7F A;  4DHL A;  3DSC A;  1S8E A;  1HO5 A;  4H2B A;  2GJU A;  4DSY A;  3D03 A;  3EGH A;  1QHW A;  4J6O A;  2YEQ A;  4LAC C;  2NYL C;  1V73 A;  5HPE A;  2Q8U A;  5B8I A;  3E7A A;  4FCX A;  3RL4 A;  4ORA A;  4ZX2 A;  3QFK A;  3IVD A;  2HYO A;  2WDC A;  1T70 A;  3ZTV A;  4MOY A;  4FBK A;  2QFR A;  3THO B;  5JJT A;  4JA7 A;  3QFO A;  1II7 A;  1Z2W A;  2WDE A;  2IAE C;  5DNY A;  5GTU A;  1M63 A;  2HY1 A;  1UTE A;  3THN A;  3PSO A;  1KBP A;  4LU9 A;  4UT3 B;  3DW8 C;  2USH A;  2IE4 C;  3JYF A;  2YVT A;  3QFM A;  4OR9 A;  3LL8 A;  1AUI A;  4F0Z A;  4V0V A;  2QFP A;  4O43 A;  3FGA C;  3H68 A;  1UF3 A;  1OIE A;  4TUG A;  2NXF A;  5F3W A;  2Z1A A; 
#chains in the Genus database with same CATH homology
 1USH A;  3IVE A;  4H2G A;  3RL3 A;  1FJM A;  1JK7 A;  4FBQ A;  4G9J A;  3IB8 A;  4V0X A;  4ZVZ A;  5EQV A;  1HPU A;  1U32 A;  4IYP C;  2BDX A;  4UWQ A;  2NPP C;  2AHD A;  4YKE A;  3DSD A;  4TUI A;  2HYP A;  3QFN A;  4KBP A;  2QJC A;  4WWL A;  4KKZ A;  4HD0 A;  3V4Y A;  2BCD A;  3H67 A;  3K7W C;  4MOV A;  1MF8 A;  4UT2 A;  5JPF A;  2P6B A;  2ZOA A;  4IL1 A;  3RQZ A;  4DT2 A;  3RL5 A;  3GVE A;  4M0V A;  3HVQ A;  1S95 A;  4O4K A;  4MP0 A;  3T1I A;  4H2F A;  4LTY A;  1T71 A;  4UT3 A;  5IOH A;  4ORB A;  3N5U A;  4O24 A;  3H62 B;  1IT6 A;  2Z72 A;  2ZO9 B;  3K7V C;  2A22 A;  5C1V A;  2WDD A;  2O8G A;  3KBP A;  4JA9 A;  2WDF A;  3IB7 A;  1OID A;  3ICF A;  2KKN A;  2Z06 A;  3H63 A;  1S3L A;  2DFJ A;  3H69 A;  1W24 A;  3ZU0 A;  4B2O A;  5INB A;  3H61 A;  1S3N A;  1OI8 A;  1S3M A;  3E7B A;  4I5N C;  5J28 A;  4O5G A;  4NZV A;  1WAO 1;  1NNW A;  1SU1 A;  2DXN A;  4H1Y P;  1HP1 A;  1XM7 A;  3H66 A;  3FLO A;  5JPE A;  4H1S A;  3P71 C;  2DXL A;  1XZW A;  3C9F A;  1G5B A;  3CK2 A;  1S70 A;  2ZBM A;  1WAR A;  2O8A A;  3QG5 C;  1QFC A;  2R17 A;  3C5W C;  1TCO A;  3EGG A;  3PSN A;  3AUZ A;  3AV0 A;  2NYM C;  4XPN A;  2IE3 C;  2JOG A;  2CV9 A;  3E0J A;  3H60 A;  2XMO A;  4H2I A;  4ORC A;  3TGH A;  1Z2X A;  2BQ8 X;  4I5L C;  3H64 A;  4FBW A;  4V0W A;  4Q7F A;  4DHL A;  3DSC A;  1S8E A;  1HO5 A;  4H2B A;  2GJU A;  4DSY A;  3D03 A;  3EGH A;  1QHW A;  4J6O A;  2YEQ A;  4LAC C;  2NYL C;  1V73 A;  5HPE A;  2Q8U A;  5B8I A;  3E7A A;  4FCX A;  3RL4 A;  4ORA A;  4ZX2 A;  3QFK A;  3IVD A;  2HYO A;  2WDC A;  1T70 A;  3ZTV A;  4MOY A;  4FBK A;  2QFR A;  3THO B;  5JJT A;  4JA7 A;  3QFO A;  1II7 A;  1Z2W A;  2WDE A;  2IAE C;  5DNY A;  5GTU A;  1M63 A;  2HY1 A;  1UTE A;  3THN A;  3PSO A;  1KBP A;  4LU9 A;  4UT3 B;  3DW8 C;  2USH A;  2IE4 C;  3JYF A;  2YVT A;  3QFM A;  4OR9 A;  3LL8 A;  1AUI A;  4F0Z A;  4V0V A;  2QFP A;  4O43 A;  3FGA C;  3H68 A;  1UF3 A;  1OIE A;  4TUG A;  2NXF A;  5F3W A;  2Z1A A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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