5IYBL

Human core-pic in the open state
Total Genus 3
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
3
sequence length
46
structure length
46
Chain Sequence
QPMIYICGECHTENEIKSRDPIRCRECGYRIMYKKRTKRLVVFDAR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Near-atomic resolution visualization of human transcription promoter opening.
pubmed doi rcsb
molecule tags Transcription, transferase/dna
source organism Homo sapiens
molecule keywords DNA-directed RNA polymerase II subunit RPB1
total genus 3
structure length 46
sequence length 46
ec nomenclature
pdb deposition date 2016-03-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
L PF03604 DNA_RNApol_7kD DNA directed RNA polymerase, 7 kDa subunit
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.20.28.30 Mainly Beta Single Sheet Rubrerythrin, domain 2 RNA polymerase ii, chain L 5iybL00
3HOUL 3S17L 4BBSL 3RZOL 1TWGL 5C3EL 2B63L 3CQZL 3I4NL 2NVXL 5IYBL 3GTJL 3GTML 2E2IL 2R93L 1R9TL 4A93L 4Y7NL 4A3EL 3S2HL 4A3KL 3I4ML 5M5XL 1TWHL 2E2HL 3S1QL 2PMZP 4A3JL 4A3CL 2JA8L 3S2DL 2JA5L 5M3ML 3S15L 1K83L 4QIWP 3PO3L 5FJ8L 5FLML 3RZDL 2Y0SP 4A3BL 4C3HL 3K7AL 3HOWL 4C3JL 3GTKL 2WAQP 3M3YL 3PO2L 5IYCL 3HOXL 1TWAL 3H0GL 1WCML 1I6HL 2WB1P 4BY7L 3HKZP 5M5WL 4AYBP 4X6AL 4C3IL 3GTOL 3H3VM 3HOVL 3S1NL 1I3QL 3GTLL 3GTQL 5IP9L 2R92L 4A3ML 5C44L 4BXXL 2YU9L 5M3FL 4A3GL 2VUML 4BY1L 1TWCL 3GTPL 5IP7L 5C4XL 3S1RL 4C2M1 5M5YL 2JA6L 3HOYL 4BBRL 3S16L 4A3FL 2NVTL 1I50L 3S1ML 4A3DL 2NVQL 3M4OL 1Y1WL 2NVYL 5IYDL 2E2JL 5C4JL 2R7ZL 1TWFL 4A3IL 1SFOL 3FKIL 3S14L 2JA7L 3GTGL 4A3LL 1Y1VL 3HOZL 4Y52L
chains in the Genus database with same CATH superfamily
3QQCE 3H9BA 3HOUL 2J9UB 2ERJA 4BBSL 1LTLA 1QQTA 4ZN1B 5C3EL 1IU6A 2R93L 4A93L 1LKPA 2AQCA 4Y7NL 4A3EL 3S2HL 2APOB 6RXNA 2M4YA 3J7Y1 3P2AA 1BFYA 1R0HA 2A69D 3S1QL 1BQ9A 1Z92B 4JAFA 1YK5A 2M4VA 3KYVA 3MSUA 4TPUA 3IU3I 5M3ML 1OWBA 1PFWA 5MGNA 5IY0A 3RYGA 3HJWB 4XXBB 5FLML 4C3HL 3H9CA 2AUSB 1RDVA 3K7AL 2Z3RB 3HOWL 3PO2L 2PVEA 2A6HD 4XGHA 2CR8A 4AI0A 3SS2A 1RYTA 2V0FA 3B08B 4C3IL 3LWOB 1VCXA 3S1NL 2NYDA 1BRFA 1I3QL 1SMMA 3GTQL 5C44L 2YU9L 5M3FL 3GTPL 2C6BA 5IP7L 5C4XL 1ZRPA 4AI3A 2JA6L 3HOYL 4JAEA 4BBRL 2XJQA 2NVTL 1C09A 3LWVB 2A6ED 4ZN3B 4ME3A 2PPTA 2E2JL 2ZIXA 5GAGc 1VZHA 1FHMA 3H99A 1RDGA 4LHNA 2EY4E 4AHYA 3S17L 2A68D 3ZG6A 1SMWA 3K35A 2B63L 5IYBL 1IROA 3GTJL 5AI3A 3RZTA 3LWQB 3KYXA 3I4ML 2MS3A 2E2HL 2H12A 1QCVA 3S2DL 5K2ME 1R0GA 2M6PA 3KYUA 4QIWP 2O5JD 3HAXC 3RZDL 1VZIA 3LWPB 1NNQA 1PZXA 1IU5A 5AI2A 4C3JL 1RB9A 3MPSA 1TWAL 1CAAA 1B2JA 2WB1P 5MFZA 3HKZP 5M5WL 4AR6A 4AYBP 1IW7D 5MLC3 5IP9L 2M6OA 1B13A 5M5YL 3S16L 1ODHA 3S1ML 1YUZA 1S24A 1Y1WL 2NVYL 2LCQA 1OWCA 5C4JL 4K9FA 2R7ZL 3FKIL 2KKDA 1B2OA 5DM71 4POGA 1LKOA 1R0JA 3A44A 3RZOL 4AHZA 1PFYA 1TWGL 2KN9A 3H97A 1E8JA 3I4NL 1P7PA 3CQZL 3GTML 1R0IA 2E2IL 1R9TL 1NXGA 4UY81 1JYBA 2V0EA 2XJSA 5GADc 4AR5A 4RXNA 2PMZP 4V196 2JA8L 4JAGA 1YK4A 1YUXA 1R0FA 1K83L 3PKJA 2XJVA 2Y0SP 3KYYA 4AHXA 1IRNA 3GTKL 4AI2A 2B5ID 3HOXL 3P8BA 2V3BB 1NXEA 4YWMA 1WCML 2CKCA 4JADA 1FHHA 5RXNA 1B71A 5GAHc 2QL0A 2RDVA 3GTOL 1YV1A 3HOVL 4E6YA 2R92L 4U671 4BXXL 5EIOC 3PWFA 4POFA 3PIO1 3JR7A 2VUML 2JI2A 1TWCL 1PFUA 3PIP1 3VPBE 2AYJA 4C2M1 4A3FL 4AHWA 3NFPI 1I50L 1RYQA 2DSXA 2ERSA 5AN9H 3M4OL 3PKIA 3B0AB 3RZ6A 2XJUA 4G6BA 2XJPA 1T9PA 5IYDL 2BE5D 1TWFL 5JVG1 4AR4A 1QYBA 3S14L 2PSMC 3LNLA 2HR5A 2RFKB 1Y1VL 3HOZL 3WWLA 4Y52L 3HJYB 1RWDA 4GS7D 2PYAA 4B8CD 3PL5A 7RXNA 2NVXL 2L0ZA 1H7VA 1F4LA 5DM61 1WJVA 2JI1A 3PZAA 5EINC 3LPEB 4A3KL 5M5XL 2Z3QB 1TWHL 3FDJA 4LHLA 4A3JL 4A3CL 2JA5L 2HVYC 1CADA 3S15L 3PO3L 5MFPA 1PFVA 5FJ8L 4A3BL 3LWRB 2XJTA 1S2ZA 1S30A 2XJRA 3KYWA 1SMUA 2C6AA 8RXNA 3J7Z1 2WAQP 3M3YL 2VL6A 2GMGA 3MQKB 2PVXA 5IYCL 3H0GL 5JVH1 1I6HL 4BY7L 1LKMA 4X6AL 1DX8A 3H3VM 5H1Sc 3GTLL 1DVBA 4A3ML 4A3GL 1BE7A 4BY1L 3WWNB 1T9OA 1T9QA 3S1RL 4WFN1 4TVMA 5MF6A 4AR3A 3QVDA 4A3DL 2NVQL 2JI3A 4YWLA 4AI1A 2K2DA 4A3IL 1SFOL 2CKAA 1VZGA 2JA7L 5GAEc 1BQ8A 3GTGL 4A3LL
chains in the Genus database with same CATH topology
3HOUL 3S17L 4BBSL 3RZOL 1TWGL 5C3EL 2B63L 3CQZL 3I4NL 2NVXL 5IYBL 3GTJL 3GTML 2E2IL 2R93L 1R9TL 4A93L 4Y7NL 4A3EL 3S2HL 4A3KL 3I4ML 5M5XL 1TWHL 2E2HL 3S1QL 2PMZP 4A3JL 4A3CL 2JA8L 3S2DL 2JA5L 5M3ML 3S15L 1K83L 4QIWP 3PO3L 5FJ8L 5FLML 3RZDL 2Y0SP 4A3BL 4C3HL 3K7AL 3HOWL 4C3JL 3GTKL 2WAQP 3M3YL 3PO2L 5IYCL 3HOXL 1TWAL 3H0GL 1WCML 1I6HL 2WB1P 4BY7L 3HKZP 5M5WL 4AYBP 4X6AL 4C3IL 3GTOL 3H3VM 3HOVL 3S1NL 1I3QL 3GTLL 3GTQL 5IP9L 2R92L 4A3ML 5C44L 4BXXL 2YU9L 5M3FL 4A3GL 2VUML 4BY1L 1TWCL 3GTPL 5IP7L 5C4XL 3S1RL 4C2M1 5M5YL 2JA6L 3HOYL 4BBRL 3S16L 4A3FL 2NVTL 1I50L 3S1ML 4A3DL 2NVQL 3M4OL 1Y1WL 2NVYL 5IYDL 2E2JL 5C4JL 2R7ZL 1TWFL 4A3IL 1SFOL 3FKIL 3S14L 2JA7L 3GTGL 4A3LL 1Y1VL 3HOZL 4Y52L
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3HOU L;  3S17 L;  4BBS L;  3RZO L;  1TWG L;  5C3E L;  2B63 L;  3CQZ L;  3I4N L;  2NVX L;  5IYB L;  3GTJ L;  3GTM L;  2E2I L;  2R93 L;  1R9T L;  4A93 L;  4Y7N L;  4A3E L;  3S2H L;  4A3K L;  3I4M L;  5M5X L;  1TWH L;  2E2H L;  3S1Q L;  2PMZ P;  4A3J L;  4A3C L;  2JA8 L;  3S2D L;  2JA5 L;  5M3M L;  3S15 L;  1K83 L;  4QIW P;  3PO3 L;  5FJ8 L;  5FLM L;  3RZD L;  2Y0S P;  4A3B L;  4C3H L;  3K7A L;  3HOW L;  4C3J L;  3GTK L;  2WAQ P;  3M3Y L;  3PO2 L;  5IYC L;  3HOX L;  1TWA L;  3H0G L;  1WCM L;  1I6H L;  2WB1 P;  4BY7 L;  3HKZ P;  5M5W L;  4AYB P;  4X6A L;  4C3I L;  3GTO L;  3H3V M;  3HOV L;  3S1N L;  1I3Q L;  3GTL L;  3GTQ L;  5IP9 L;  2R92 L;  4A3M L;  5C44 L;  4BXX L;  2YU9 L;  5M3F L;  4A3G L;  2VUM L;  4BY1 L;  1TWC L;  3GTP L;  5IP7 L;  5C4X L;  3S1R L;  4C2M 1;  5M5Y L;  2JA6 L;  3HOY L;  4BBR L;  3S16 L;  4A3F L;  2NVT L;  1I50 L;  3S1M L;  4A3D L;  2NVQ L;  3M4O L;  1Y1W L;  2NVY L;  5IYD L;  2E2J L;  5C4J L;  2R7Z L;  1TWF L;  4A3I L;  1SFO L;  3FKI L;  3S14 L;  2JA7 L;  3GTG L;  4A3L L;  1Y1V L;  3HOZ L;  4Y52 L; 
#chains in the Genus database with same CATH topology
 3QQC E;  3H9B A;  3HOU L;  2J9U B;  2ERJ A;  4BBS L;  1LTL A;  1QQT A;  4ZN1 B;  5C3E L;  1IU6 A;  2R93 L;  4A93 L;  1LKP A;  2AQC A;  4Y7N L;  4A3E L;  3S2H L;  2APO B;  6RXN A;  2M4Y A;  3J7Y 1;  3P2A A;  1BFY A;  1R0H A;  2A69 D;  3S1Q L;  1BQ9 A;  1Z92 B;  4JAF A;  1YK5 A;  2M4V A;  3KYV A;  3MSU A;  4TPU A;  3IU3 I;  5M3M L;  1OWB A;  1PFW A;  5MGN A;  5IY0 A;  3RYG A;  3HJW B;  4XXB B;  5FLM L;  4C3H L;  3H9C A;  2AUS B;  1RDV A;  3K7A L;  2Z3R B;  3HOW L;  3PO2 L;  2PVE A;  2A6H D;  4XGH A;  2CR8 A;  4AI0 A;  3SS2 A;  1RYT A;  2V0F A;  3B08 B;  4C3I L;  3LWO B;  1VCX A;  3S1N L;  2NYD A;  1BRF A;  1I3Q L;  1SMM A;  3GTQ L;  5C44 L;  2YU9 L;  5M3F L;  3GTP L;  2C6B A;  5IP7 L;  5C4X L;  1ZRP A;  4AI3 A;  2JA6 L;  3HOY L;  4JAE A;  4BBR L;  2XJQ A;  2NVT L;  1C09 A;  3LWV B;  2A6E D;  4ZN3 B;  4ME3 A;  2PPT A;  2E2J L;  2ZIX A;  5GAG c;  1VZH A;  1FHM A;  3H99 A;  1RDG A;  4LHN A;  2EY4 E;  4AHY A;  3S17 L;  2A68 D;  3ZG6 A;  1SMW A;  3K35 A;  2B63 L;  5IYB L;  1IRO A;  3GTJ L;  5AI3 A;  3RZT A;  3LWQ B;  3KYX A;  3I4M L;  2MS3 A;  2E2H L;  2H12 A;  1QCV A;  3S2D L;  5K2M E;  1R0G A;  2M6P A;  3KYU A;  4QIW P;  2O5J D;  3HAX C;  3RZD L;  1VZI A;  3LWP B;  1NNQ A;  1PZX A;  1IU5 A;  5AI2 A;  4C3J L;  1RB9 A;  3MPS A;  1TWA L;  1CAA A;  1B2J A;  2WB1 P;  5MFZ A;  3HKZ P;  5M5W L;  4AR6 A;  4AYB P;  1IW7 D;  5MLC 3;  5IP9 L;  2M6O A;  1B13 A;  5M5Y L;  3S16 L;  1ODH A;  3S1M L;  1YUZ A;  1S24 A;  1Y1W L;  2NVY L;  2LCQ A;  1OWC A;  5C4J L;  4K9F A;  2R7Z L;  3FKI L;  2KKD A;  1B2O A;  5DM7 1;  4POG A;  1LKO A;  1R0J A;  3A44 A;  3RZO L;  4AHZ A;  1PFY A;  1TWG L;  2KN9 A;  3H97 A;  1E8J A;  3I4N L;  1P7P A;  3CQZ L;  3GTM L;  1R0I A;  2E2I L;  1R9T L;  1NXG A;  4UY8 1;  1JYB A;  2V0E A;  2XJS A;  5GAD c;  4AR5 A;  4RXN A;  2PMZ P;  4V19 6;  2JA8 L;  4JAG A;  1YK4 A;  1YUX A;  1R0F A;  1K83 L;  3PKJ A;  2XJV A;  2Y0S P;  3KYY A;  4AHX A;  1IRN A;  3GTK L;  4AI2 A;  2B5I D;  3HOX L;  3P8B A;  2V3B B;  1NXE A;  4YWM A;  1WCM L;  2CKC A;  4JAD A;  1FHH A;  5RXN A;  1B71 A;  5GAH c;  2QL0 A;  2RDV A;  3GTO L;  1YV1 A;  3HOV L;  4E6Y A;  2R92 L;  4U67 1;  4BXX L;  5EIO C;  3PWF A;  4POF A;  3PIO 1;  3JR7 A;  2VUM L;  2JI2 A;  1TWC L;  1PFU A;  3PIP 1;  3VPB E;  2AYJ A;  4C2M 1;  4A3F L;  4AHW A;  3NFP I;  1I50 L;  1RYQ A;  2DSX A;  2ERS A;  5AN9 H;  3M4O L;  3PKI A;  3B0A B;  3RZ6 A;  2XJU A;  4G6B A;  2XJP A;  1T9P A;  5IYD L;  2BE5 D;  1TWF L;  5JVG 1;  4AR4 A;  1QYB A;  3S14 L;  2PSM C;  3LNL A;  2HR5 A;  2RFK B;  1Y1V L;  3HOZ L;  3WWL A;  4Y52 L;  3HJY B;  1RWD A;  4GS7 D;  2PYA A;  4B8C D;  3PL5 A;  7RXN A;  2NVX L;  2L0Z A;  1H7V A;  1F4L A;  5DM6 1;  1WJV A;  2JI1 A;  3PZA A;  5EIN C;  3LPE B;  4A3K L;  5M5X L;  2Z3Q B;  1TWH L;  3FDJ A;  4LHL A;  4A3J L;  4A3C L;  2JA5 L;  2HVY C;  1CAD A;  3S15 L;  3PO3 L;  5MFP A;  1PFV A;  5FJ8 L;  4A3B L;  3LWR B;  2XJT A;  1S2Z A;  1S30 A;  2XJR A;  3KYW A;  1SMU A;  2C6A A;  8RXN A;  3J7Z 1;  2WAQ P;  3M3Y L;  2VL6 A;  2GMG A;  3MQK B;  2PVX A;  5IYC L;  3H0G L;  5JVH 1;  1I6H L;  4BY7 L;  1LKM A;  4X6A L;  1DX8 A;  3H3V M;  5H1S c;  3GTL L;  1DVB A;  4A3M L;  4A3G L;  1BE7 A;  4BY1 L;  3WWN B;  1T9O A;  1T9Q A;  3S1R L;  4WFN 1;  4TVM A;  5MF6 A;  4AR3 A;  3QVD A;  4A3D L;  2NVQ L;  2JI3 A;  4YWL A;  4AI1 A;  2K2D A;  4A3I L;  1SFO L;  2CKA A;  1VZG A;  2JA7 L;  5GAE c;  1BQ8 A;  3GTG L;  4A3L L; 
#chains in the Genus database with same CATH homology
 3HOU L;  3S17 L;  4BBS L;  3RZO L;  1TWG L;  5C3E L;  2B63 L;  3CQZ L;  3I4N L;  2NVX L;  5IYB L;  3GTJ L;  3GTM L;  2E2I L;  2R93 L;  1R9T L;  4A93 L;  4Y7N L;  4A3E L;  3S2H L;  4A3K L;  3I4M L;  5M5X L;  1TWH L;  2E2H L;  3S1Q L;  2PMZ P;  4A3J L;  4A3C L;  2JA8 L;  3S2D L;  2JA5 L;  5M3M L;  3S15 L;  1K83 L;  4QIW P;  3PO3 L;  5FJ8 L;  5FLM L;  3RZD L;  2Y0S P;  4A3B L;  4C3H L;  3K7A L;  3HOW L;  4C3J L;  3GTK L;  2WAQ P;  3M3Y L;  3PO2 L;  5IYC L;  3HOX L;  1TWA L;  3H0G L;  1WCM L;  1I6H L;  2WB1 P;  4BY7 L;  3HKZ P;  5M5W L;  4AYB P;  4X6A L;  4C3I L;  3GTO L;  3H3V M;  3HOV L;  3S1N L;  1I3Q L;  3GTL L;  3GTQ L;  5IP9 L;  2R92 L;  4A3M L;  5C44 L;  4BXX L;  2YU9 L;  5M3F L;  4A3G L;  2VUM L;  4BY1 L;  1TWC L;  3GTP L;  5IP7 L;  5C4X L;  3S1R L;  4C2M 1;  5M5Y L;  2JA6 L;  3HOY L;  4BBR L;  3S16 L;  4A3F L;  2NVT L;  1I50 L;  3S1M L;  4A3D L;  2NVQ L;  3M4O L;  1Y1W L;  2NVY L;  5IYD L;  2E2J L;  5C4J L;  2R7Z L;  1TWF L;  4A3I L;  1SFO L;  3FKI L;  3S14 L;  2JA7 L;  3GTG L;  4A3L L;  1Y1V L;  3HOZ L;  4Y52 L; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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