2W8G | Genus

Total Genus 49

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	49
sequence length	205
structure length	205
Chain Sequence	QANLMRLKSDLFNRSPMYPGPTKDDPLTVTLGFTLQDIVKVDSSTNEVDLVYYEQQRWKLNSLMWDPNEYGNITDFRTSAADIWTPDITAYSSTRPVQVLSPQIAVVTHDGSVMFIPAQRLSFMCDPTGVDSEEGVTCAVKFGSWVYSGFEIDLKTDTDQVDLSSYYASSKYEILSATQTRQVQHYSCCPEPYIDVNLVVKFRER

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

loadScript /static/js/j2s/core/package.js

loadScript /static/js/j2s/core/corejmol.z.js

loadScript /static/js/j2s/core/corescript.z.js

JSmol exec jmolApplet0 start applet null

Jmol JavaScript applet jmolApplet0__273387571264609__ initializing

Jmol getValue debug null

Jmol getValue logLevel null

Jmol getValue allowjavascript null

AppletRegistry.checkIn(jmolApplet0__273387571264609__)

vwrOptions:

{ "name":"jmolApplet0","applet":true,"documentBase":"https://genus.fuw.edu.pl/view/2W8G/A/","platform":"J.awtjs2d.Platform","fullName":"jmolApplet0__273387571264609__","codePath":"https:/static/js/j2s/","display":"jmolApplet0_canvas2d","signedApplet":"true","appletReadyCallback":"Jmol._readyCallback","statusListener":"[J.appletjs.Jmol object]","syncId":"273387571264609","bgcolor":"white" }

setting document base to "https://genus.fuw.edu.pl/view/2W8G/A/"

Jmol Version: 14.29.13 2018-04-17 17:17

java.vendor: Java2Script (HTML5)

java.version: 2018-01-28 23:38:52 (JSmol/j2s)

os.name: Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)

Access: ALL

memory: 0.0/0.0

processors available: 1

useCommandThread: false

appletId:jmolApplet0 (signed)

Jmol getValue emulate null

defaults = "Jmol"

Jmol getValue boxbgcolor null

Jmol getValue bgcolor white

backgroundColor = "white"

Jmol getValue ANIMFRAMECallback null

Jmol getValue APPLETREADYCallback Jmol._readyCallback

APPLETREADYCallback = "Jmol._readyCallback"

callback set for APPLETREADYCallback Jmol._readyCallback APPLETREADY

Jmol getValue ATOMMOVEDCallback null

Jmol getValue AUDIOCallback null

Jmol getValue CLICKCallback null

Jmol getValue DRAGDROPCallback null

Jmol getValue ECHOCallback null

Jmol getValue ERRORCallback null

Jmol getValue EVALCallback null

Jmol getValue HOVERCallback null

Jmol getValue IMAGECallback null

Jmol getValue LOADSTRUCTCallback null

Jmol getValue MEASURECallback null

Jmol getValue MESSAGECallback null

Jmol getValue MINIMIZATIONCallback null

Jmol getValue SERVICECallback null

Jmol getValue PICKCallback null

Jmol getValue RESIZECallback null

Jmol getValue SCRIPTCallback null

Jmol getValue SYNCCallback null

Jmol getValue STRUCTUREMODIFIEDCallback null

Jmol getValue doTranslate null

language=en_US

Jmol getValue popupMenu null

Jmol getValue script null

Jmol getValue loadInline null

Jmol getValue load null

Jmol applet jmolApplet0__273387571264609__ ready

script 1 started

platformSpeed = 8

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

molecule tags	Receptor
publication title	Use of Acetylcholine Binding Protein in the Search for Novel Alpha7 Nicotinic Receptor Ligands. In Silico Docking, Pharmacological Screening, and X- Ray Analysis. pubmed doi rcsb
molecule keywords	SOLUBLE ACETYLCHOLINE RECEPTOR
total genus	49
structure length	205
sequence length	205
chains with identical sequence	B, C, D, E
ec nomenclature
pdb deposition date	2009-01-16

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF02931	Neur_chan_LBD	Neurotransmitter-gated ion-channel ligand binding domain

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
2.70.170.10	Mainly Beta	Distorted Sandwich	Acetylcholine Binding Protein; Chain: A,	Neurotransmitter-gated ion-channel ligand-binding domain	2w8gA00

4B5DA 4ZK4A 2Y58A 5CFBA 4TWDA 4XHEA 3P50A 2XQ3A 5AFLA 5J5IA 2BYQA 5J5FA 4ZJTA 2WNCA 2Y56A 3GUAA 3JADA 4ZR6A 5J0ZA 2UZ6A 3TLTA 4BQTA 2XQ8A 3TLVA 4TNVA 4HFCA 5CO5A 3WTKA 4ALXA 2BJ0A 5SYOA 4DBMA 3U8KA 2XQ5A 4IREA 4QACA 2BG9B 2XQ6A 3ZDGA 5BP0A 2XZ6A 3ZDHA 3P4WA 1UV6A 4UY2A 3UU3A 4XK9A 2C9TA 3RI5A 2X00A 4QAAA 2BG9C 4TNWA 5FJVA 4A97A 4EZ1A 2YMEA 2WN9A 3WTLA 5KE4A 5LXBA 5AINA 3UU4A 3PEOA 3T4MA 2BYPA 2YOEA 3EAMA 5HEHA 4UM3S 4NPPA 5AFMA 5BW2A 3UQ4A 5HEJA 2BG9A 3TLSA 3UU6A 4ZZCA 2BYRA 5L4EA 3WTMA 2VL0A 4ZZBA 4ZJSA 3U8NA 3UU8A 3ZKRA 4ILCA 4IL9A 3JAFA 4QH4A 5AFJA 5TVCA 4LMJA 5AFHA 4WV9A 4UM3P 5JMEA 4TWHA 4HFBA 2XNVA 3SH1A 5KZUA 4LMLA 2YN6A 4HFIA 3WTHA 2PGZA 5J5HA 3IGQA 3RHWA 3U8LA 4HFEA 5IUXA 3WIPA 5J5GA 2XZ5A 3SQ9A 5L47A 4FRRA 3C84A 4UXUA 2W8GA 4HFHA 3SIOA 3WTJA 2XNUA 3RQUA 3RQWA 5LG3A 4HFDA 2XQ9A 4COFA 2X00D 5AFNA 4D01A 3UU5A 5BRXA 5L4HA 3U8MA 4ZK1A 1I9BA 2Y7YA 3LSVA 3TLWA 3WTIA 5HEOA 1UW6A 4QABA 2XYSA 3PMZA 2QC1B 4BFQA 5HEGA 5AFKA 4NZBA 2XQ4A 4ILBA 4A98A 2PH9A 2ZJVA 2WNJA 4QH1A 3UUBA 4IL4A 2BR8A 3SQ6A 4Z90A 3WTNA 4PIRA 3EI0A 3RIFA 3TLUA 4AFHA 4TWFA 2YKSA 4LMKA 2BYSA 3WTOA 4AFGA 4UM3A 4ILAA 2Y57A 5AFMB 2ZJUA 3C79A 3RIAA 2WZYA 4Z91A 5HCJA 4F8HA 2BR7A 4HQPA 4UM1A 4X5TA 5HCMA 2XNTA 2BYNA 2XQ7A 2XYTA 2XQAA 2Y54A 3JAEA 3U8JA 2YMDA 5HEUA 4AFTA 4ZRUA 1UX2A 3EHZA 2WNLA 2BG9E 3UQ7A 2W8FA 4QH5A
chains in the Genus database with same CATH superfamily

#chains in the Genus database with same CATH superfamily
 4B5D A;  4ZK4 A;  2Y58 A;  5CFB A;  4TWD A;  4XHE A;  3P50 A;  2XQ3 A;  5AFL A;  5J5I A;  2BYQ A;  5J5F A;  4ZJT A;  2WNC A;  2Y56 A;  3GUA A;  3JAD A;  4ZR6 A;  5J0Z A;  2UZ6 A;  3TLT A;  4BQT A;  2XQ8 A;  3TLV A;  4TNV A;  4HFC A;  5CO5 A;  3WTK A;  4ALX A;  2BJ0 A;  5SYO A;  4DBM A;  3U8K A;  2XQ5 A;  4IRE A;  4QAC A;  2BG9 B;  2XQ6 A;  3ZDG A;  5BP0 A;  2XZ6 A;  3ZDH A;  3P4W A;  1UV6 A;  4UY2 A;  3UU3 A;  4XK9 A;  2C9T A;  3RI5 A;  2X00 A;  4QAA A;  2BG9 C;  4TNW A;  5FJV A;  4A97 A;  4EZ1 A;  2YME A;  2WN9 A;  3WTL A;  5KE4 A;  5LXB A;  5AIN A;  3UU4 A;  3PEO A;  3T4M A;  2BYP A;  2YOE A;  3EAM A;  5HEH A;  4UM3 S;  4NPP A;  5AFM A;  5BW2 A;  3UQ4 A;  5HEJ A;  2BG9 A;  3TLS A;  3UU6 A;  4ZZC A;  2BYR A;  5L4E A;  3WTM A;  2VL0 A;  4ZZB A;  4ZJS A;  3U8N A;  3UU8 A;  3ZKR A;  4ILC A;  4IL9 A;  3JAF A;  4QH4 A;  5AFJ A;  5TVC A;  4LMJ A;  5AFH A;  4WV9 A;  4UM3 P;  5JME A;  4TWH A;  4HFB A;  2XNV A;  3SH1 A;  5KZU A;  4LML A;  2YN6 A;  4HFI A;  3WTH A;  2PGZ A;  5J5H A;  3IGQ A;  3RHW A;  3U8L A;  4HFE A;  5IUX A;  3WIP A;  5J5G A;  2XZ5 A;  3SQ9 A;  5L47 A;  4FRR A;  3C84 A;  4UXU A;  2W8G A;  4HFH A;  3SIO A;  3WTJ A;  2XNU A;  3RQU A;  3RQW A;  5LG3 A;  4HFD A;  2XQ9 A;  4COF A;  2X00 D;  5AFN A;  4D01 A;  3UU5 A;  5BRX A;  5L4H A;  3U8M A;  4ZK1 A;  1I9B A;  2Y7Y A;  3LSV A;  3TLW A;  3WTI A;  5HEO A;  1UW6 A;  4QAB A;  2XYS A;  3PMZ A;  2QC1 B;  4BFQ A;  5HEG A;  5AFK A;  4NZB A;  2XQ4 A;  4ILB A;  4A98 A;  2PH9 A;  2ZJV A;  2WNJ A;  4QH1 A;  3UUB A;  4IL4 A;  2BR8 A;  3SQ6 A;  4Z90 A;  3WTN A;  4PIR A;  3EI0 A;  3RIF A;  3TLU A;  4AFH A;  4TWF A;  2YKS A;  4LMK A;  2BYS A;  3WTO A;  4AFG A;  4UM3 A;  4ILA A;  2Y57 A;  5AFM B;  2ZJU A;  3C79 A;  3RIA A;  2WZY A;  4Z91 A;  5HCJ A;  4F8H A;  2BR7 A;  4HQP A;  4UM1 A;  4X5T A;  5HCM A;  2XNT A;  2BYN A;  2XQ7 A;  2XYT A;  2XQA A;  2Y54 A;  3JAE A;  3U8J A;  2YMD A;  5HEU A;  4AFT A;  4ZRU A;  1UX2 A;  3EHZ A;  2WNL A;  2BG9 E;  3UQ7 A;  2W8F A;  4QH5 A; 
#chains in the Genus database with same CATH topology
 4B5D A;  4ZK4 A;  2Y58 A;  5CFB A;  4TWD A;  4XHE A;  3P50 A;  2XQ3 A;  5AFL A;  5J5I A;  2BYQ A;  5J5F A;  4ZJT A;  2WNC A;  2Y56 A;  3GUA A;  3JAD A;  4ZR6 A;  5J0Z A;  2UZ6 A;  3TLT A;  4BQT A;  2XQ8 A;  3TLV A;  4TNV A;  4HFC A;  5CO5 A;  3WTK A;  4ALX A;  2BJ0 A;  5SYO A;  4DBM A;  3U8K A;  2XQ5 A;  4IRE A;  4QAC A;  2BG9 B;  2XQ6 A;  3ZDG A;  5BP0 A;  2XZ6 A;  3ZDH A;  3P4W A;  1UV6 A;  4UY2 A;  3UU3 A;  4XK9 A;  2C9T A;  3RI5 A;  2X00 A;  4QAA A;  2BG9 C;  4TNW A;  5FJV A;  4A97 A;  4EZ1 A;  2YME A;  2WN9 A;  3WTL A;  5KE4 A;  5LXB A;  5AIN A;  3UU4 A;  3PEO A;  3T4M A;  2BYP A;  2YOE A;  3EAM A;  5HEH A;  4UM3 S;  4NPP A;  5AFM A;  5BW2 A;  3UQ4 A;  5HEJ A;  2BG9 A;  3TLS A;  3UU6 A;  4ZZC A;  2BYR A;  5L4E A;  3WTM A;  2VL0 A;  4ZZB A;  4ZJS A;  3U8N A;  3UU8 A;  3ZKR A;  4ILC A;  4IL9 A;  3JAF A;  4QH4 A;  5AFJ A;  5TVC A;  4LMJ A;  5AFH A;  4WV9 A;  4UM3 P;  5JME A;  4TWH A;  4HFB A;  2XNV A;  3SH1 A;  5KZU A;  4LML A;  2YN6 A;  4HFI A;  3WTH A;  2PGZ A;  5J5H A;  3IGQ A;  3RHW A;  3U8L A;  4HFE A;  5IUX A;  3WIP A;  5J5G A;  2XZ5 A;  3SQ9 A;  5L47 A;  4FRR A;  3C84 A;  4UXU A;  2W8G A;  4HFH A;  3SIO A;  3WTJ A;  2XNU A;  3RQU A;  3RQW A;  5LG3 A;  4HFD A;  2XQ9 A;  4COF A;  2X00 D;  5AFN A;  4D01 A;  3UU5 A;  5BRX A;  5L4H A;  3U8M A;  4ZK1 A;  1I9B A;  2Y7Y A;  3LSV A;  3TLW A;  3WTI A;  5HEO A;  1UW6 A;  4QAB A;  2XYS A;  3PMZ A;  2QC1 B;  4BFQ A;  5HEG A;  5AFK A;  4NZB A;  2XQ4 A;  4ILB A;  4A98 A;  2PH9 A;  2ZJV A;  2WNJ A;  4QH1 A;  3UUB A;  4IL4 A;  2BR8 A;  3SQ6 A;  4Z90 A;  3WTN A;  4PIR A;  3EI0 A;  3RIF A;  3TLU A;  4AFH A;  4TWF A;  2YKS A;  4LMK A;  2BYS A;  3WTO A;  4AFG A;  4UM3 A;  4ILA A;  2Y57 A;  5AFM B;  2ZJU A;  3C79 A;  3RIA A;  2WZY A;  4Z91 A;  5HCJ A;  4F8H A;  2BR7 A;  4HQP A;  4UM1 A;  4X5T A;  5HCM A;  2XNT A;  2BYN A;  2XQ7 A;  2XYT A;  2XQA A;  2Y54 A;  3JAE A;  3U8J A;  2YMD A;  5HEU A;  4AFT A;  4ZRU A;  1UX2 A;  3EHZ A;  2WNL A;  2BG9 E;  3UQ7 A;  2W8F A;  4QH5 A; 
#chains in the Genus database with same CATH homology
 4B5D A;  4ZK4 A;  2Y58 A;  5CFB A;  4TWD A;  4XHE A;  3P50 A;  2XQ3 A;  5AFL A;  5J5I A;  2BYQ A;  5J5F A;  4ZJT A;  2WNC A;  2Y56 A;  3GUA A;  3JAD A;  4ZR6 A;  5J0Z A;  2UZ6 A;  3TLT A;  4BQT A;  2XQ8 A;  3TLV A;  4TNV A;  4HFC A;  5CO5 A;  3WTK A;  4ALX A;  2BJ0 A;  5SYO A;  4DBM A;  3U8K A;  2XQ5 A;  4IRE A;  4QAC A;  2BG9 B;  2XQ6 A;  3ZDG A;  5BP0 A;  2XZ6 A;  3ZDH A;  3P4W A;  1UV6 A;  4UY2 A;  3UU3 A;  4XK9 A;  2C9T A;  3RI5 A;  2X00 A;  4QAA A;  2BG9 C;  4TNW A;  5FJV A;  4A97 A;  4EZ1 A;  2YME A;  2WN9 A;  3WTL A;  5KE4 A;  5LXB A;  5AIN A;  3UU4 A;  3PEO A;  3T4M A;  2BYP A;  2YOE A;  3EAM A;  5HEH A;  4UM3 S;  4NPP A;  5AFM A;  5BW2 A;  3UQ4 A;  5HEJ A;  2BG9 A;  3TLS A;  3UU6 A;  4ZZC A;  2BYR A;  5L4E A;  3WTM A;  2VL0 A;  4ZZB A;  4ZJS A;  3U8N A;  3UU8 A;  3ZKR A;  4ILC A;  4IL9 A;  3JAF A;  4QH4 A;  5AFJ A;  5TVC A;  4LMJ A;  5AFH A;  4WV9 A;  4UM3 P;  5JME A;  4TWH A;  4HFB A;  2XNV A;  3SH1 A;  5KZU A;  4LML A;  2YN6 A;  4HFI A;  3WTH A;  2PGZ A;  5J5H A;  3IGQ A;  3RHW A;  3U8L A;  4HFE A;  5IUX A;  3WIP A;  5J5G A;  2XZ5 A;  3SQ9 A;  5L47 A;  4FRR A;  3C84 A;  4UXU A;  2W8G A;  4HFH A;  3SIO A;  3WTJ A;  2XNU A;  3RQU A;  3RQW A;  5LG3 A;  4HFD A;  2XQ9 A;  4COF A;  2X00 D;  5AFN A;  4D01 A;  3UU5 A;  5BRX A;  5L4H A;  3U8M A;  4ZK1 A;  1I9B A;  2Y7Y A;  3LSV A;  3TLW A;  3WTI A;  5HEO A;  1UW6 A;  4QAB A;  2XYS A;  3PMZ A;  2QC1 B;  4BFQ A;  5HEG A;  5AFK A;  4NZB A;  2XQ4 A;  4ILB A;  4A98 A;  2PH9 A;  2ZJV A;  2WNJ A;  4QH1 A;  3UUB A;  4IL4 A;  2BR8 A;  3SQ6 A;  4Z90 A;  3WTN A;  4PIR A;  3EI0 A;  3RIF A;  3TLU A;  4AFH A;  4TWF A;  2YKS A;  4LMK A;  2BYS A;  3WTO A;  4AFG A;  4UM3 A;  4ILA A;  2Y57 A;  5AFM B;  2ZJU A;  3C79 A;  3RIA A;  2WZY A;  4Z91 A;  5HCJ A;  4F8H A;  2BR7 A;  4HQP A;  4UM1 A;  4X5T A;  5HCM A;  2XNT A;  2BYN A;  2XQ7 A;  2XYT A;  2XQA A;  2Y54 A;  3JAE A;  3U8J A;  2YMD A;  5HEU A;  4AFT A;  4ZRU A;  1UX2 A;  3EHZ A;  2WNL A;  2BG9 E;  3UQ7 A;  2W8F A;  4QH5 A;

...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)

...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...

2W8GA

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations