4QABA

X-ray structure of acetylcholine binding protein (achbp) in complex with 4-(morpholin-4-yl)-6-[4-(trifluoromethyl)phenyl]pyrimidin-2-amine
Total Genus 43
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
43
sequence length
213
structure length
208
Chain Sequence
DYKDDDDKLDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLARVVSDGEVLYMPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural basis for cooperative interactions of substituted 2-aminopyrimidines with the acetylcholine binding protein.
pubmed doi rcsb
molecule tags Acetylcholine-binding protein
source organism Lymnaea stagnalis
molecule keywords Acetylcholine-binding protein
total genus 43
structure length 208
sequence length 213
chains with identical sequence B, C, D, E, F, G, H, I, J
ec nomenclature
pdb deposition date 2014-05-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02931 Neur_chan_LBD Neurotransmitter-gated ion-channel ligand binding domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.170.10 Mainly Beta Distorted Sandwich Acetylcholine Binding Protein; Chain: A, Neurotransmitter-gated ion-channel ligand-binding domain 4qabA00
4HQPA 2XQ6A 5J5FA 2W8FA 5HEUA 3WTIA 5J5GA 3WTKA 4TWFA 3PEOA 5AFKA 3U8JA 1UV6A 4WV9A 3UUBA 3WTLA 5FJVA 3ZKRA 3UQ7A 4UY2A 3U8NA 1I9BA 2X00A 4Z90A 4LMLA 2WNLA 4TWDA 3U8KA 4IREA 3JAFA 5AFLA 2XQ7A 3RHWA 4EZ1A 4COFA 2BG9C 3EI0A 5KZUA 3PMZA 4ZR6A 2XQ5A 3RI5A 4X5TA 4D01A 2BG9E 3ZDHA 2BYNA 3RQWA 5TVCA 3WTHA 3EHZA 4QH4A 5SYOA 4ALXA 5AFNA 2Y7YA 4NZBA 4B5DA 4QAAA 4UM3P 3UQ4A 2YOEA 5LXBA 2XNVA 5CO5A 4HFIA 3JADA 3SQ6A 5HCMA 4ILAA 4DBMA 3UU8A 2XQAA 2ZJUA 3RQUA 4ZK4A 4BQTA 2XYTA 4ILBA 5AFJA 3TLUA 2Y56A 5BP0A 4HFCA 3P50A 2YKSA 3RIFA 2YMDA 2XQ9A 4QH1A 4LMJA 2WNJA 2XNUA 4ZRUA 2XYSA 4ZJTA 4QH5A 4ZJSA 2WZYA 4A98A 4AFTA 5J0ZA 2XNTA 5CFBA 5J5IA 3TLWA 5AFMB 3U8MA 2XQ8A 5L4EA 3TLVA 2W8GA 4A97A 5L47A 3JAEA 5JMEA 3UU6A 2YMEA 2BYPA 2VL0A 4HFHA 4HFDA 3ZDGA 3P4WA 5HEHA 4HFEA 3TLSA 4FRRA 5HCJA 2XZ5A 1UW6A 2BR7A 3IGQA 4QACA 2BYRA 4BFQA 5AFMA 5BRXA 2XZ6A 4UM1A 5KE4A 2PGZA 3U8LA 4ZZCA 4ZK1A 2Y57A 2BG9B 2C9TA 5HEJA 5AINA 4QABA 4IL9A 5J5HA 2WN9A 3WTNA 4XK9A 3UU4A 5LG3A 3LSVA 2BR8A 3C79A 2BJ0A 3T4MA 4HFBA 5BW2A 2Y58A 2YN6A 4LMKA 2XQ3A 4ILCA 4AFHA 4TNVA 2X00D 4F8HA 5AFHA 5HEGA 3UU3A 2PH9A 3EAMA 4PIRA 3C84A 4TNWA 4TWHA 2ZJVA 4UXUA 2BG9A 5L4HA 4IL4A 3RIAA 3SIOA 2BYQA 3SQ9A 3GUAA 3SH1A 3WTJA 2Y54A 4AFGA 4ZZBA 1UX2A 4XHEA 3TLTA 3UU5A 2BYSA 4UM3A 4UM3S 2XQ4A 3WTOA 4NPPA 2QC1B 5HEOA 5IUXA 3WIPA 2UZ6A 4Z91A 3WTMA 2WNCA
chains in the Genus database with same CATH superfamily
4HQPA 2XQ6A 5J5FA 2W8FA 5HEUA 3WTIA 5J5GA 3WTKA 4TWFA 3PEOA 5AFKA 3U8JA 1UV6A 4WV9A 3UUBA 3WTLA 5FJVA 3ZKRA 3UQ7A 4UY2A 3U8NA 1I9BA 2X00A 4Z90A 4LMLA 2WNLA 4TWDA 3U8KA 4IREA 3JAFA 5AFLA 2XQ7A 3RHWA 4EZ1A 4COFA 2BG9C 3EI0A 5KZUA 3PMZA 4ZR6A 2XQ5A 3RI5A 4X5TA 4D01A 2BG9E 3ZDHA 2BYNA 3RQWA 5TVCA 3WTHA 3EHZA 4QH4A 5SYOA 4ALXA 5AFNA 2Y7YA 4NZBA 4B5DA 4QAAA 4UM3P 3UQ4A 2YOEA 5LXBA 2XNVA 5CO5A 4HFIA 3JADA 3SQ6A 5HCMA 4ILAA 4DBMA 3UU8A 2XQAA 2ZJUA 3RQUA 4ZK4A 4BQTA 2XYTA 4ILBA 5AFJA 3TLUA 2Y56A 5BP0A 4HFCA 3P50A 2YKSA 3RIFA 2YMDA 2XQ9A 4QH1A 4LMJA 2WNJA 2XNUA 4ZRUA 2XYSA 4ZJTA 4QH5A 4ZJSA 2WZYA 4A98A 4AFTA 5J0ZA 2XNTA 5CFBA 5J5IA 3TLWA 5AFMB 3U8MA 2XQ8A 5L4EA 3TLVA 2W8GA 4A97A 5L47A 3JAEA 5JMEA 3UU6A 2YMEA 2BYPA 2VL0A 4HFHA 4HFDA 3ZDGA 3P4WA 5HEHA 4HFEA 3TLSA 4FRRA 5HCJA 2XZ5A 1UW6A 2BR7A 3IGQA 4QACA 2BYRA 4BFQA 5AFMA 5BRXA 2XZ6A 4UM1A 5KE4A 2PGZA 3U8LA 4ZZCA 4ZK1A 2Y57A 2BG9B 2C9TA 5HEJA 5AINA 4QABA 4IL9A 5J5HA 2WN9A 3WTNA 4XK9A 3UU4A 5LG3A 3LSVA 2BR8A 3C79A 2BJ0A 3T4MA 4HFBA 5BW2A 2Y58A 2YN6A 4LMKA 2XQ3A 4ILCA 4AFHA 4TNVA 2X00D 4F8HA 5AFHA 5HEGA 3UU3A 2PH9A 3EAMA 4PIRA 3C84A 4TNWA 4TWHA 2ZJVA 4UXUA 2BG9A 5L4HA 4IL4A 3RIAA 3SIOA 2BYQA 3SQ9A 3GUAA 3SH1A 3WTJA 2Y54A 4AFGA 4ZZBA 1UX2A 4XHEA 3TLTA 3UU5A 2BYSA 4UM3A 4UM3S 2XQ4A 3WTOA 4NPPA 2QC1B 5HEOA 5IUXA 3WIPA 2UZ6A 4Z91A 3WTMA 2WNCA
chains in the Genus database with same CATH topology
4HQPA 2XQ6A 5J5FA 2W8FA 5HEUA 3WTIA 5J5GA 3WTKA 4TWFA 3PEOA 5AFKA 3U8JA 1UV6A 4WV9A 3UUBA 3WTLA 5FJVA 3ZKRA 3UQ7A 4UY2A 3U8NA 1I9BA 2X00A 4Z90A 4LMLA 2WNLA 4TWDA 3U8KA 4IREA 3JAFA 5AFLA 2XQ7A 3RHWA 4EZ1A 4COFA 2BG9C 3EI0A 5KZUA 3PMZA 4ZR6A 2XQ5A 3RI5A 4X5TA 4D01A 2BG9E 3ZDHA 2BYNA 3RQWA 5TVCA 3WTHA 3EHZA 4QH4A 5SYOA 4ALXA 5AFNA 2Y7YA 4NZBA 4B5DA 4QAAA 4UM3P 3UQ4A 2YOEA 5LXBA 2XNVA 5CO5A 4HFIA 3JADA 3SQ6A 5HCMA 4ILAA 4DBMA 3UU8A 2XQAA 2ZJUA 3RQUA 4ZK4A 4BQTA 2XYTA 4ILBA 5AFJA 3TLUA 2Y56A 5BP0A 4HFCA 3P50A 2YKSA 3RIFA 2YMDA 2XQ9A 4QH1A 4LMJA 2WNJA 2XNUA 4ZRUA 2XYSA 4ZJTA 4QH5A 4ZJSA 2WZYA 4A98A 4AFTA 5J0ZA 2XNTA 5CFBA 5J5IA 3TLWA 5AFMB 3U8MA 2XQ8A 5L4EA 3TLVA 2W8GA 4A97A 5L47A 3JAEA 5JMEA 3UU6A 2YMEA 2BYPA 2VL0A 4HFHA 4HFDA 3ZDGA 3P4WA 5HEHA 4HFEA 3TLSA 4FRRA 5HCJA 2XZ5A 1UW6A 2BR7A 3IGQA 4QACA 2BYRA 4BFQA 5AFMA 5BRXA 2XZ6A 4UM1A 5KE4A 2PGZA 3U8LA 4ZZCA 4ZK1A 2Y57A 2BG9B 2C9TA 5HEJA 5AINA 4QABA 4IL9A 5J5HA 2WN9A 3WTNA 4XK9A 3UU4A 5LG3A 3LSVA 2BR8A 3C79A 2BJ0A 3T4MA 4HFBA 5BW2A 2Y58A 2YN6A 4LMKA 2XQ3A 4ILCA 4AFHA 4TNVA 2X00D 4F8HA 5AFHA 5HEGA 3UU3A 2PH9A 3EAMA 4PIRA 3C84A 4TNWA 4TWHA 2ZJVA 4UXUA 2BG9A 5L4HA 4IL4A 3RIAA 3SIOA 2BYQA 3SQ9A 3GUAA 3SH1A 3WTJA 2Y54A 4AFGA 4ZZBA 1UX2A 4XHEA 3TLTA 3UU5A 2BYSA 4UM3A 4UM3S 2XQ4A 3WTOA 4NPPA 2QC1B 5HEOA 5IUXA 3WIPA 2UZ6A 4Z91A 3WTMA 2WNCA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4HQP A;  2XQ6 A;  5J5F A;  2W8F A;  5HEU A;  3WTI A;  5J5G A;  3WTK A;  4TWF A;  3PEO A;  5AFK A;  3U8J A;  1UV6 A;  4WV9 A;  3UUB A;  3WTL A;  5FJV A;  3ZKR A;  3UQ7 A;  4UY2 A;  3U8N A;  1I9B A;  2X00 A;  4Z90 A;  4LML A;  2WNL A;  4TWD A;  3U8K A;  4IRE A;  3JAF A;  5AFL A;  2XQ7 A;  3RHW A;  4EZ1 A;  4COF A;  2BG9 C;  3EI0 A;  5KZU A;  3PMZ A;  4ZR6 A;  2XQ5 A;  3RI5 A;  4X5T A;  4D01 A;  2BG9 E;  3ZDH A;  2BYN A;  3RQW A;  5TVC A;  3WTH A;  3EHZ A;  4QH4 A;  5SYO A;  4ALX A;  5AFN A;  2Y7Y A;  4NZB A;  4B5D A;  4QAA A;  4UM3 P;  3UQ4 A;  2YOE A;  5LXB A;  2XNV A;  5CO5 A;  4HFI A;  3JAD A;  3SQ6 A;  5HCM A;  4ILA A;  4DBM A;  3UU8 A;  2XQA A;  2ZJU A;  3RQU A;  4ZK4 A;  4BQT A;  2XYT A;  4ILB A;  5AFJ A;  3TLU A;  2Y56 A;  5BP0 A;  4HFC A;  3P50 A;  2YKS A;  3RIF A;  2YMD A;  2XQ9 A;  4QH1 A;  4LMJ A;  2WNJ A;  2XNU A;  4ZRU A;  2XYS A;  4ZJT A;  4QH5 A;  4ZJS A;  2WZY A;  4A98 A;  4AFT A;  5J0Z A;  2XNT A;  5CFB A;  5J5I A;  3TLW A;  5AFM B;  3U8M A;  2XQ8 A;  5L4E A;  3TLV A;  2W8G A;  4A97 A;  5L47 A;  3JAE A;  5JME A;  3UU6 A;  2YME A;  2BYP A;  2VL0 A;  4HFH A;  4HFD A;  3ZDG A;  3P4W A;  5HEH A;  4HFE A;  3TLS A;  4FRR A;  5HCJ A;  2XZ5 A;  1UW6 A;  2BR7 A;  3IGQ A;  4QAC A;  2BYR A;  4BFQ A;  5AFM A;  5BRX A;  2XZ6 A;  4UM1 A;  5KE4 A;  2PGZ A;  3U8L A;  4ZZC A;  4ZK1 A;  2Y57 A;  2BG9 B;  2C9T A;  5HEJ A;  5AIN A;  4QAB A;  4IL9 A;  5J5H A;  2WN9 A;  3WTN A;  4XK9 A;  3UU4 A;  5LG3 A;  3LSV A;  2BR8 A;  3C79 A;  2BJ0 A;  3T4M A;  4HFB A;  5BW2 A;  2Y58 A;  2YN6 A;  4LMK A;  2XQ3 A;  4ILC A;  4AFH A;  4TNV A;  2X00 D;  4F8H A;  5AFH A;  5HEG A;  3UU3 A;  2PH9 A;  3EAM A;  4PIR A;  3C84 A;  4TNW A;  4TWH A;  2ZJV A;  4UXU A;  2BG9 A;  5L4H A;  4IL4 A;  3RIA A;  3SIO A;  2BYQ A;  3SQ9 A;  3GUA A;  3SH1 A;  3WTJ A;  2Y54 A;  4AFG A;  4ZZB A;  1UX2 A;  4XHE A;  3TLT A;  3UU5 A;  2BYS A;  4UM3 A;  4UM3 S;  2XQ4 A;  3WTO A;  4NPP A;  2QC1 B;  5HEO A;  5IUX A;  3WIP A;  2UZ6 A;  4Z91 A;  3WTM A;  2WNC A; 
#chains in the Genus database with same CATH topology
 4HQP A;  2XQ6 A;  5J5F A;  2W8F A;  5HEU A;  3WTI A;  5J5G A;  3WTK A;  4TWF A;  3PEO A;  5AFK A;  3U8J A;  1UV6 A;  4WV9 A;  3UUB A;  3WTL A;  5FJV A;  3ZKR A;  3UQ7 A;  4UY2 A;  3U8N A;  1I9B A;  2X00 A;  4Z90 A;  4LML A;  2WNL A;  4TWD A;  3U8K A;  4IRE A;  3JAF A;  5AFL A;  2XQ7 A;  3RHW A;  4EZ1 A;  4COF A;  2BG9 C;  3EI0 A;  5KZU A;  3PMZ A;  4ZR6 A;  2XQ5 A;  3RI5 A;  4X5T A;  4D01 A;  2BG9 E;  3ZDH A;  2BYN A;  3RQW A;  5TVC A;  3WTH A;  3EHZ A;  4QH4 A;  5SYO A;  4ALX A;  5AFN A;  2Y7Y A;  4NZB A;  4B5D A;  4QAA A;  4UM3 P;  3UQ4 A;  2YOE A;  5LXB A;  2XNV A;  5CO5 A;  4HFI A;  3JAD A;  3SQ6 A;  5HCM A;  4ILA A;  4DBM A;  3UU8 A;  2XQA A;  2ZJU A;  3RQU A;  4ZK4 A;  4BQT A;  2XYT A;  4ILB A;  5AFJ A;  3TLU A;  2Y56 A;  5BP0 A;  4HFC A;  3P50 A;  2YKS A;  3RIF A;  2YMD A;  2XQ9 A;  4QH1 A;  4LMJ A;  2WNJ A;  2XNU A;  4ZRU A;  2XYS A;  4ZJT A;  4QH5 A;  4ZJS A;  2WZY A;  4A98 A;  4AFT A;  5J0Z A;  2XNT A;  5CFB A;  5J5I A;  3TLW A;  5AFM B;  3U8M A;  2XQ8 A;  5L4E A;  3TLV A;  2W8G A;  4A97 A;  5L47 A;  3JAE A;  5JME A;  3UU6 A;  2YME A;  2BYP A;  2VL0 A;  4HFH A;  4HFD A;  3ZDG A;  3P4W A;  5HEH A;  4HFE A;  3TLS A;  4FRR A;  5HCJ A;  2XZ5 A;  1UW6 A;  2BR7 A;  3IGQ A;  4QAC A;  2BYR A;  4BFQ A;  5AFM A;  5BRX A;  2XZ6 A;  4UM1 A;  5KE4 A;  2PGZ A;  3U8L A;  4ZZC A;  4ZK1 A;  2Y57 A;  2BG9 B;  2C9T A;  5HEJ A;  5AIN A;  4QAB A;  4IL9 A;  5J5H A;  2WN9 A;  3WTN A;  4XK9 A;  3UU4 A;  5LG3 A;  3LSV A;  2BR8 A;  3C79 A;  2BJ0 A;  3T4M A;  4HFB A;  5BW2 A;  2Y58 A;  2YN6 A;  4LMK A;  2XQ3 A;  4ILC A;  4AFH A;  4TNV A;  2X00 D;  4F8H A;  5AFH A;  5HEG A;  3UU3 A;  2PH9 A;  3EAM A;  4PIR A;  3C84 A;  4TNW A;  4TWH A;  2ZJV A;  4UXU A;  2BG9 A;  5L4H A;  4IL4 A;  3RIA A;  3SIO A;  2BYQ A;  3SQ9 A;  3GUA A;  3SH1 A;  3WTJ A;  2Y54 A;  4AFG A;  4ZZB A;  1UX2 A;  4XHE A;  3TLT A;  3UU5 A;  2BYS A;  4UM3 A;  4UM3 S;  2XQ4 A;  3WTO A;  4NPP A;  2QC1 B;  5HEO A;  5IUX A;  3WIP A;  2UZ6 A;  4Z91 A;  3WTM A;  2WNC A; 
#chains in the Genus database with same CATH homology
 4HQP A;  2XQ6 A;  5J5F A;  2W8F A;  5HEU A;  3WTI A;  5J5G A;  3WTK A;  4TWF A;  3PEO A;  5AFK A;  3U8J A;  1UV6 A;  4WV9 A;  3UUB A;  3WTL A;  5FJV A;  3ZKR A;  3UQ7 A;  4UY2 A;  3U8N A;  1I9B A;  2X00 A;  4Z90 A;  4LML A;  2WNL A;  4TWD A;  3U8K A;  4IRE A;  3JAF A;  5AFL A;  2XQ7 A;  3RHW A;  4EZ1 A;  4COF A;  2BG9 C;  3EI0 A;  5KZU A;  3PMZ A;  4ZR6 A;  2XQ5 A;  3RI5 A;  4X5T A;  4D01 A;  2BG9 E;  3ZDH A;  2BYN A;  3RQW A;  5TVC A;  3WTH A;  3EHZ A;  4QH4 A;  5SYO A;  4ALX A;  5AFN A;  2Y7Y A;  4NZB A;  4B5D A;  4QAA A;  4UM3 P;  3UQ4 A;  2YOE A;  5LXB A;  2XNV A;  5CO5 A;  4HFI A;  3JAD A;  3SQ6 A;  5HCM A;  4ILA A;  4DBM A;  3UU8 A;  2XQA A;  2ZJU A;  3RQU A;  4ZK4 A;  4BQT A;  2XYT A;  4ILB A;  5AFJ A;  3TLU A;  2Y56 A;  5BP0 A;  4HFC A;  3P50 A;  2YKS A;  3RIF A;  2YMD A;  2XQ9 A;  4QH1 A;  4LMJ A;  2WNJ A;  2XNU A;  4ZRU A;  2XYS A;  4ZJT A;  4QH5 A;  4ZJS A;  2WZY A;  4A98 A;  4AFT A;  5J0Z A;  2XNT A;  5CFB A;  5J5I A;  3TLW A;  5AFM B;  3U8M A;  2XQ8 A;  5L4E A;  3TLV A;  2W8G A;  4A97 A;  5L47 A;  3JAE A;  5JME A;  3UU6 A;  2YME A;  2BYP A;  2VL0 A;  4HFH A;  4HFD A;  3ZDG A;  3P4W A;  5HEH A;  4HFE A;  3TLS A;  4FRR A;  5HCJ A;  2XZ5 A;  1UW6 A;  2BR7 A;  3IGQ A;  4QAC A;  2BYR A;  4BFQ A;  5AFM A;  5BRX A;  2XZ6 A;  4UM1 A;  5KE4 A;  2PGZ A;  3U8L A;  4ZZC A;  4ZK1 A;  2Y57 A;  2BG9 B;  2C9T A;  5HEJ A;  5AIN A;  4QAB A;  4IL9 A;  5J5H A;  2WN9 A;  3WTN A;  4XK9 A;  3UU4 A;  5LG3 A;  3LSV A;  2BR8 A;  3C79 A;  2BJ0 A;  3T4M A;  4HFB A;  5BW2 A;  2Y58 A;  2YN6 A;  4LMK A;  2XQ3 A;  4ILC A;  4AFH A;  4TNV A;  2X00 D;  4F8H A;  5AFH A;  5HEG A;  3UU3 A;  2PH9 A;  3EAM A;  4PIR A;  3C84 A;  4TNW A;  4TWH A;  2ZJV A;  4UXU A;  2BG9 A;  5L4H A;  4IL4 A;  3RIA A;  3SIO A;  2BYQ A;  3SQ9 A;  3GUA A;  3SH1 A;  3WTJ A;  2Y54 A;  4AFG A;  4ZZB A;  1UX2 A;  4XHE A;  3TLT A;  3UU5 A;  2BYS A;  4UM3 A;  4UM3 S;  2XQ4 A;  3WTO A;  4NPP A;  2QC1 B;  5HEO A;  5IUX A;  3WIP A;  2UZ6 A;  4Z91 A;  3WTM A;  2WNC A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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