2XNUA

Acetylcholine binding protein (achbp) as template for hierarchical in silico screening procedures to identify structurally novel ligands for the nicotinic receptors
Total Genus 50
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
50
sequence length
205
structure length
205
Chain Sequence
QANLMRLKSDLFNRSPMYPGPTKDDPLTVTLGFTLQDIVKVDSSTNEVDLVYYEQQRWKLNSLMWDPNEYGNITDFRTSAADIWTPDITAYSSTRPVQVLSPQIAVVTHDGSVMFIPAQRLSFMCDPTGVDSEEGVTCAVKFGSWVYSGFEIDLKTDTDQVDLSSYYASSKYEILSATQTRQVQHYSCCPEPYIDVNLVVKFRER
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Acetylcholine Binding Protein (Achbp) as Template for Hierarchical in Silico Screening Procedures to Identify Structurally Novel Ligands for the Nicotinic Receptors.
pubmed doi rcsb
molecule tags Receptor
source organism Aplysia californica
molecule keywords SOLUBLE ACETYLCHOLINE RECEPTOR
total genus 50
structure length 205
sequence length 205
chains with identical sequence B, C, D, E
ec nomenclature
pdb deposition date 2010-08-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02931 Neur_chan_LBD Neurotransmitter-gated ion-channel ligand binding domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.170.10 Mainly Beta Distorted Sandwich Acetylcholine Binding Protein; Chain: A, Neurotransmitter-gated ion-channel ligand-binding domain 2xnuA00
5HEGA 2X00A 4UY2A 2BG9B 4ZRUA 3ZDGA 2XQ5A 5J5FA 2ZJVA 3TLSA 4TWHA 4FRRA 3PMZA 3UQ7A 4UM3A 2BYSA 3UU8A 5J5IA 3RIFA 2W8GA 3WTOA 4IL9A 4WV9A 3UUBA 5AFMA 2Y58A 2XQ9A 4Z91A 5IUXA 4TWFA 5KE4A 5KZUA 3PEOA 5L4EA 4QABA 4ILCA 4TWDA 2PGZA 3SH1A 2BYQA 4QH5A 3RIAA 2XQ8A 2XQ4A 4HFHA 4UM1A 5AFLA 4IREA 3C79A 3P4WA 2UZ6A 3JAEA 2YN6A 5BW2A 3GUAA 5HEHA 4IL4A 5AFJA 5CO5A 3C84A 5JMEA 4TNWA 4ZK4A 3T4MA 2C9TA 2W8FA 2YMDA 4A98A 2BJ0A 3U8JA 2YKSA 2Y7YA 3EI0A 5HEJA 4Z90A 4ALXA 4HFBA 2XQ3A 3UQ4A 3TLUA 5AFMB 2PH9A 4ZJTA 2YOEA 2XNTA 2WN9A 2WNCA 2XNVA 2BG9C 4ILBA 2XZ6A 5J5GA 4EZ1A 4UM3S 1UV6A 3JADA 4QACA 3UU4A 3TLWA 4BFQA 5LXBA 3WTIA 4HFCA 5SYOA 4BQTA 2WZYA 2XYTA 2BYRA 4AFHA 5HEOA 4HFEA 1UW6A 2BYPA 3SQ9A 5CFBA 2Y57A 3U8NA 4XHEA 3RI5A 5L47A 3TLTA 3SQ6A 2X00D 4PIRA 4QH1A 4ZR6A 4A97A 5AFNA 5HCJA 3WIPA 5BP0A 4COFA 4HQPA 4HFIA 2XQAA 4LMLA 4NPPA 5FJVA 5TVCA 3WTHA 4AFTA 3WTLA 4ZJSA 2ZJUA 3SIOA 4DBMA 4LMJA 4ZK1A 4ZZBA 3U8MA 4AFGA 4X5TA 2BR7A 3U8LA 2BG9A 2XZ5A 4ILAA 4LMKA 3IGQA 3WTNA 4D01A 1UX2A 3P50A 4TNVA 2BG9E 5HEUA 2WNLA 5J5HA 2XQ7A 2Y56A 2YMEA 4HFDA 4QAAA 4ZZCA 1I9BA 2VL0A 2BR8A 5AINA 5J0ZA 2XYSA 4UM3P 5AFKA 3LSVA 5L4HA 2QC1B 4UXUA 3U8KA 2WNJA 3RQUA 4B5DA 3JAFA 3RHWA 5AFHA 5BRXA 3ZKRA 3EAMA 3WTKA 5LG3A 2BYNA 3UU3A 2XQ6A 4NZBA 3UU6A 4F8HA 4XK9A 3WTMA 3TLVA 3EHZA 2XNUA 3UU5A 3ZDHA 5HCMA 3WTJA 4QH4A 2Y54A 3RQWA
chains in the Genus database with same CATH superfamily
5HEGA 2X00A 4UY2A 2BG9B 4ZRUA 3ZDGA 2XQ5A 5J5FA 2ZJVA 3TLSA 4TWHA 4FRRA 3PMZA 3UQ7A 4UM3A 2BYSA 3UU8A 5J5IA 3RIFA 2W8GA 3WTOA 4IL9A 4WV9A 3UUBA 5AFMA 2Y58A 2XQ9A 4Z91A 5IUXA 4TWFA 5KE4A 5KZUA 3PEOA 5L4EA 4QABA 4ILCA 4TWDA 2PGZA 3SH1A 2BYQA 4QH5A 3RIAA 2XQ8A 2XQ4A 4HFHA 4UM1A 5AFLA 4IREA 3C79A 3P4WA 2UZ6A 3JAEA 2YN6A 5BW2A 3GUAA 5HEHA 4IL4A 5AFJA 5CO5A 3C84A 5JMEA 4TNWA 4ZK4A 3T4MA 2C9TA 2W8FA 2YMDA 4A98A 2BJ0A 3U8JA 2YKSA 2Y7YA 3EI0A 5HEJA 4Z90A 4ALXA 4HFBA 2XQ3A 3UQ4A 3TLUA 5AFMB 2PH9A 4ZJTA 2YOEA 2XNTA 2WN9A 2WNCA 2XNVA 2BG9C 4ILBA 2XZ6A 5J5GA 4EZ1A 4UM3S 1UV6A 3JADA 4QACA 3UU4A 3TLWA 4BFQA 5LXBA 3WTIA 4HFCA 5SYOA 4BQTA 2WZYA 2XYTA 2BYRA 4AFHA 5HEOA 4HFEA 1UW6A 2BYPA 3SQ9A 5CFBA 2Y57A 3U8NA 4XHEA 3RI5A 5L47A 3TLTA 3SQ6A 2X00D 4PIRA 4QH1A 4ZR6A 4A97A 5AFNA 5HCJA 3WIPA 5BP0A 4COFA 4HQPA 4HFIA 2XQAA 4LMLA 4NPPA 5FJVA 5TVCA 3WTHA 4AFTA 3WTLA 4ZJSA 2ZJUA 3SIOA 4DBMA 4LMJA 4ZK1A 4ZZBA 3U8MA 4AFGA 4X5TA 2BR7A 3U8LA 2BG9A 2XZ5A 4ILAA 4LMKA 3IGQA 3WTNA 4D01A 1UX2A 3P50A 4TNVA 2BG9E 5HEUA 2WNLA 5J5HA 2XQ7A 2Y56A 2YMEA 4HFDA 4QAAA 4ZZCA 1I9BA 2VL0A 2BR8A 5AINA 5J0ZA 2XYSA 4UM3P 5AFKA 3LSVA 5L4HA 2QC1B 4UXUA 3U8KA 2WNJA 3RQUA 4B5DA 3JAFA 3RHWA 5AFHA 5BRXA 3ZKRA 3EAMA 3WTKA 5LG3A 2BYNA 3UU3A 2XQ6A 4NZBA 3UU6A 4F8HA 4XK9A 3WTMA 3TLVA 3EHZA 2XNUA 3UU5A 3ZDHA 5HCMA 3WTJA 4QH4A 2Y54A 3RQWA
chains in the Genus database with same CATH topology
5HEGA 2X00A 4UY2A 2BG9B 4ZRUA 3ZDGA 2XQ5A 5J5FA 2ZJVA 3TLSA 4TWHA 4FRRA 3PMZA 3UQ7A 4UM3A 2BYSA 3UU8A 5J5IA 3RIFA 2W8GA 3WTOA 4IL9A 4WV9A 3UUBA 5AFMA 2Y58A 2XQ9A 4Z91A 5IUXA 4TWFA 5KE4A 5KZUA 3PEOA 5L4EA 4QABA 4ILCA 4TWDA 2PGZA 3SH1A 2BYQA 4QH5A 3RIAA 2XQ8A 2XQ4A 4HFHA 4UM1A 5AFLA 4IREA 3C79A 3P4WA 2UZ6A 3JAEA 2YN6A 5BW2A 3GUAA 5HEHA 4IL4A 5AFJA 5CO5A 3C84A 5JMEA 4TNWA 4ZK4A 3T4MA 2C9TA 2W8FA 2YMDA 4A98A 2BJ0A 3U8JA 2YKSA 2Y7YA 3EI0A 5HEJA 4Z90A 4ALXA 4HFBA 2XQ3A 3UQ4A 3TLUA 5AFMB 2PH9A 4ZJTA 2YOEA 2XNTA 2WN9A 2WNCA 2XNVA 2BG9C 4ILBA 2XZ6A 5J5GA 4EZ1A 4UM3S 1UV6A 3JADA 4QACA 3UU4A 3TLWA 4BFQA 5LXBA 3WTIA 4HFCA 5SYOA 4BQTA 2WZYA 2XYTA 2BYRA 4AFHA 5HEOA 4HFEA 1UW6A 2BYPA 3SQ9A 5CFBA 2Y57A 3U8NA 4XHEA 3RI5A 5L47A 3TLTA 3SQ6A 2X00D 4PIRA 4QH1A 4ZR6A 4A97A 5AFNA 5HCJA 3WIPA 5BP0A 4COFA 4HQPA 4HFIA 2XQAA 4LMLA 4NPPA 5FJVA 5TVCA 3WTHA 4AFTA 3WTLA 4ZJSA 2ZJUA 3SIOA 4DBMA 4LMJA 4ZK1A 4ZZBA 3U8MA 4AFGA 4X5TA 2BR7A 3U8LA 2BG9A 2XZ5A 4ILAA 4LMKA 3IGQA 3WTNA 4D01A 1UX2A 3P50A 4TNVA 2BG9E 5HEUA 2WNLA 5J5HA 2XQ7A 2Y56A 2YMEA 4HFDA 4QAAA 4ZZCA 1I9BA 2VL0A 2BR8A 5AINA 5J0ZA 2XYSA 4UM3P 5AFKA 3LSVA 5L4HA 2QC1B 4UXUA 3U8KA 2WNJA 3RQUA 4B5DA 3JAFA 3RHWA 5AFHA 5BRXA 3ZKRA 3EAMA 3WTKA 5LG3A 2BYNA 3UU3A 2XQ6A 4NZBA 3UU6A 4F8HA 4XK9A 3WTMA 3TLVA 3EHZA 2XNUA 3UU5A 3ZDHA 5HCMA 3WTJA 4QH4A 2Y54A 3RQWA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5HEG A;  2X00 A;  4UY2 A;  2BG9 B;  4ZRU A;  3ZDG A;  2XQ5 A;  5J5F A;  2ZJV A;  3TLS A;  4TWH A;  4FRR A;  3PMZ A;  3UQ7 A;  4UM3 A;  2BYS A;  3UU8 A;  5J5I A;  3RIF A;  2W8G A;  3WTO A;  4IL9 A;  4WV9 A;  3UUB A;  5AFM A;  2Y58 A;  2XQ9 A;  4Z91 A;  5IUX A;  4TWF A;  5KE4 A;  5KZU A;  3PEO A;  5L4E A;  4QAB A;  4ILC A;  4TWD A;  2PGZ A;  3SH1 A;  2BYQ A;  4QH5 A;  3RIA A;  2XQ8 A;  2XQ4 A;  4HFH A;  4UM1 A;  5AFL A;  4IRE A;  3C79 A;  3P4W A;  2UZ6 A;  3JAE A;  2YN6 A;  5BW2 A;  3GUA A;  5HEH A;  4IL4 A;  5AFJ A;  5CO5 A;  3C84 A;  5JME A;  4TNW A;  4ZK4 A;  3T4M A;  2C9T A;  2W8F A;  2YMD A;  4A98 A;  2BJ0 A;  3U8J A;  2YKS A;  2Y7Y A;  3EI0 A;  5HEJ A;  4Z90 A;  4ALX A;  4HFB A;  2XQ3 A;  3UQ4 A;  3TLU A;  5AFM B;  2PH9 A;  4ZJT A;  2YOE A;  2XNT A;  2WN9 A;  2WNC A;  2XNV A;  2BG9 C;  4ILB A;  2XZ6 A;  5J5G A;  4EZ1 A;  4UM3 S;  1UV6 A;  3JAD A;  4QAC A;  3UU4 A;  3TLW A;  4BFQ A;  5LXB A;  3WTI A;  4HFC A;  5SYO A;  4BQT A;  2WZY A;  2XYT A;  2BYR A;  4AFH A;  5HEO A;  4HFE A;  1UW6 A;  2BYP A;  3SQ9 A;  5CFB A;  2Y57 A;  3U8N A;  4XHE A;  3RI5 A;  5L47 A;  3TLT A;  3SQ6 A;  2X00 D;  4PIR A;  4QH1 A;  4ZR6 A;  4A97 A;  5AFN A;  5HCJ A;  3WIP A;  5BP0 A;  4COF A;  4HQP A;  4HFI A;  2XQA A;  4LML A;  4NPP A;  5FJV A;  5TVC A;  3WTH A;  4AFT A;  3WTL A;  4ZJS A;  2ZJU A;  3SIO A;  4DBM A;  4LMJ A;  4ZK1 A;  4ZZB A;  3U8M A;  4AFG A;  4X5T A;  2BR7 A;  3U8L A;  2BG9 A;  2XZ5 A;  4ILA A;  4LMK A;  3IGQ A;  3WTN A;  4D01 A;  1UX2 A;  3P50 A;  4TNV A;  2BG9 E;  5HEU A;  2WNL A;  5J5H A;  2XQ7 A;  2Y56 A;  2YME A;  4HFD A;  4QAA A;  4ZZC A;  1I9B A;  2VL0 A;  2BR8 A;  5AIN A;  5J0Z A;  2XYS A;  4UM3 P;  5AFK A;  3LSV A;  5L4H A;  2QC1 B;  4UXU A;  3U8K A;  2WNJ A;  3RQU A;  4B5D A;  3JAF A;  3RHW A;  5AFH A;  5BRX A;  3ZKR A;  3EAM A;  3WTK A;  5LG3 A;  2BYN A;  3UU3 A;  2XQ6 A;  4NZB A;  3UU6 A;  4F8H A;  4XK9 A;  3WTM A;  3TLV A;  3EHZ A;  2XNU A;  3UU5 A;  3ZDH A;  5HCM A;  3WTJ A;  4QH4 A;  2Y54 A;  3RQW A; 
#chains in the Genus database with same CATH topology
 5HEG A;  2X00 A;  4UY2 A;  2BG9 B;  4ZRU A;  3ZDG A;  2XQ5 A;  5J5F A;  2ZJV A;  3TLS A;  4TWH A;  4FRR A;  3PMZ A;  3UQ7 A;  4UM3 A;  2BYS A;  3UU8 A;  5J5I A;  3RIF A;  2W8G A;  3WTO A;  4IL9 A;  4WV9 A;  3UUB A;  5AFM A;  2Y58 A;  2XQ9 A;  4Z91 A;  5IUX A;  4TWF A;  5KE4 A;  5KZU A;  3PEO A;  5L4E A;  4QAB A;  4ILC A;  4TWD A;  2PGZ A;  3SH1 A;  2BYQ A;  4QH5 A;  3RIA A;  2XQ8 A;  2XQ4 A;  4HFH A;  4UM1 A;  5AFL A;  4IRE A;  3C79 A;  3P4W A;  2UZ6 A;  3JAE A;  2YN6 A;  5BW2 A;  3GUA A;  5HEH A;  4IL4 A;  5AFJ A;  5CO5 A;  3C84 A;  5JME A;  4TNW A;  4ZK4 A;  3T4M A;  2C9T A;  2W8F A;  2YMD A;  4A98 A;  2BJ0 A;  3U8J A;  2YKS A;  2Y7Y A;  3EI0 A;  5HEJ A;  4Z90 A;  4ALX A;  4HFB A;  2XQ3 A;  3UQ4 A;  3TLU A;  5AFM B;  2PH9 A;  4ZJT A;  2YOE A;  2XNT A;  2WN9 A;  2WNC A;  2XNV A;  2BG9 C;  4ILB A;  2XZ6 A;  5J5G A;  4EZ1 A;  4UM3 S;  1UV6 A;  3JAD A;  4QAC A;  3UU4 A;  3TLW A;  4BFQ A;  5LXB A;  3WTI A;  4HFC A;  5SYO A;  4BQT A;  2WZY A;  2XYT A;  2BYR A;  4AFH A;  5HEO A;  4HFE A;  1UW6 A;  2BYP A;  3SQ9 A;  5CFB A;  2Y57 A;  3U8N A;  4XHE A;  3RI5 A;  5L47 A;  3TLT A;  3SQ6 A;  2X00 D;  4PIR A;  4QH1 A;  4ZR6 A;  4A97 A;  5AFN A;  5HCJ A;  3WIP A;  5BP0 A;  4COF A;  4HQP A;  4HFI A;  2XQA A;  4LML A;  4NPP A;  5FJV A;  5TVC A;  3WTH A;  4AFT A;  3WTL A;  4ZJS A;  2ZJU A;  3SIO A;  4DBM A;  4LMJ A;  4ZK1 A;  4ZZB A;  3U8M A;  4AFG A;  4X5T A;  2BR7 A;  3U8L A;  2BG9 A;  2XZ5 A;  4ILA A;  4LMK A;  3IGQ A;  3WTN A;  4D01 A;  1UX2 A;  3P50 A;  4TNV A;  2BG9 E;  5HEU A;  2WNL A;  5J5H A;  2XQ7 A;  2Y56 A;  2YME A;  4HFD A;  4QAA A;  4ZZC A;  1I9B A;  2VL0 A;  2BR8 A;  5AIN A;  5J0Z A;  2XYS A;  4UM3 P;  5AFK A;  3LSV A;  5L4H A;  2QC1 B;  4UXU A;  3U8K A;  2WNJ A;  3RQU A;  4B5D A;  3JAF A;  3RHW A;  5AFH A;  5BRX A;  3ZKR A;  3EAM A;  3WTK A;  5LG3 A;  2BYN A;  3UU3 A;  2XQ6 A;  4NZB A;  3UU6 A;  4F8H A;  4XK9 A;  3WTM A;  3TLV A;  3EHZ A;  2XNU A;  3UU5 A;  3ZDH A;  5HCM A;  3WTJ A;  4QH4 A;  2Y54 A;  3RQW A; 
#chains in the Genus database with same CATH homology
 5HEG A;  2X00 A;  4UY2 A;  2BG9 B;  4ZRU A;  3ZDG A;  2XQ5 A;  5J5F A;  2ZJV A;  3TLS A;  4TWH A;  4FRR A;  3PMZ A;  3UQ7 A;  4UM3 A;  2BYS A;  3UU8 A;  5J5I A;  3RIF A;  2W8G A;  3WTO A;  4IL9 A;  4WV9 A;  3UUB A;  5AFM A;  2Y58 A;  2XQ9 A;  4Z91 A;  5IUX A;  4TWF A;  5KE4 A;  5KZU A;  3PEO A;  5L4E A;  4QAB A;  4ILC A;  4TWD A;  2PGZ A;  3SH1 A;  2BYQ A;  4QH5 A;  3RIA A;  2XQ8 A;  2XQ4 A;  4HFH A;  4UM1 A;  5AFL A;  4IRE A;  3C79 A;  3P4W A;  2UZ6 A;  3JAE A;  2YN6 A;  5BW2 A;  3GUA A;  5HEH A;  4IL4 A;  5AFJ A;  5CO5 A;  3C84 A;  5JME A;  4TNW A;  4ZK4 A;  3T4M A;  2C9T A;  2W8F A;  2YMD A;  4A98 A;  2BJ0 A;  3U8J A;  2YKS A;  2Y7Y A;  3EI0 A;  5HEJ A;  4Z90 A;  4ALX A;  4HFB A;  2XQ3 A;  3UQ4 A;  3TLU A;  5AFM B;  2PH9 A;  4ZJT A;  2YOE A;  2XNT A;  2WN9 A;  2WNC A;  2XNV A;  2BG9 C;  4ILB A;  2XZ6 A;  5J5G A;  4EZ1 A;  4UM3 S;  1UV6 A;  3JAD A;  4QAC A;  3UU4 A;  3TLW A;  4BFQ A;  5LXB A;  3WTI A;  4HFC A;  5SYO A;  4BQT A;  2WZY A;  2XYT A;  2BYR A;  4AFH A;  5HEO A;  4HFE A;  1UW6 A;  2BYP A;  3SQ9 A;  5CFB A;  2Y57 A;  3U8N A;  4XHE A;  3RI5 A;  5L47 A;  3TLT A;  3SQ6 A;  2X00 D;  4PIR A;  4QH1 A;  4ZR6 A;  4A97 A;  5AFN A;  5HCJ A;  3WIP A;  5BP0 A;  4COF A;  4HQP A;  4HFI A;  2XQA A;  4LML A;  4NPP A;  5FJV A;  5TVC A;  3WTH A;  4AFT A;  3WTL A;  4ZJS A;  2ZJU A;  3SIO A;  4DBM A;  4LMJ A;  4ZK1 A;  4ZZB A;  3U8M A;  4AFG A;  4X5T A;  2BR7 A;  3U8L A;  2BG9 A;  2XZ5 A;  4ILA A;  4LMK A;  3IGQ A;  3WTN A;  4D01 A;  1UX2 A;  3P50 A;  4TNV A;  2BG9 E;  5HEU A;  2WNL A;  5J5H A;  2XQ7 A;  2Y56 A;  2YME A;  4HFD A;  4QAA A;  4ZZC A;  1I9B A;  2VL0 A;  2BR8 A;  5AIN A;  5J0Z A;  2XYS A;  4UM3 P;  5AFK A;  3LSV A;  5L4H A;  2QC1 B;  4UXU A;  3U8K A;  2WNJ A;  3RQU A;  4B5D A;  3JAF A;  3RHW A;  5AFH A;  5BRX A;  3ZKR A;  3EAM A;  3WTK A;  5LG3 A;  2BYN A;  3UU3 A;  2XQ6 A;  4NZB A;  3UU6 A;  4F8H A;  4XK9 A;  3WTM A;  3TLV A;  3EHZ A;  2XNU A;  3UU5 A;  3ZDH A;  5HCM A;  3WTJ A;  4QH4 A;  2Y54 A;  3RQW A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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