3SH1A

Ac-achbp ligand binding domain mutated to human alpha-7 nachr
Total Genus 50
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
50
sequence length
214
structure length
214
Chain Sequence
DDDDKLHSQANLMRLKSDLFNRSPMYPGPTKDDPLTVYLSFSLLDIVKADSSTNEVDLVYWEQQSWKLNSLMWDPNEYGNITDFRTSAADIWTPDITAYSSTRPVQVLSPQNALVNSSGHVQYLPAQRLSFMCDPTGVDSEEGATCAVKFGSWSYGGWEIDLKTDTDQVDLSSYYASSKYEILSATQTRSERFYECCKEPYPDVNLVVKFRERR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Creating an alpha-7 nicotinic acetylcholine recognition domain from the acetylcholine binding protein: crystallographic and ligand selectivity analyses
pubmed doi rcsb
molecule tags Receptor
source organism Aplysia californica
molecule keywords Soluble acetylcholine receptor
total genus 50
structure length 214
sequence length 214
chains with identical sequence B, C, D, E, F, G, H, I, J
ec nomenclature
pdb deposition date 2011-06-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02931 Neur_chan_LBD Neurotransmitter-gated ion-channel ligand binding domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.170.10 Mainly Beta Distorted Sandwich Acetylcholine Binding Protein; Chain: A, Neurotransmitter-gated ion-channel ligand-binding domain 3sh1A00
3ZDGA 3PMZA 2XQ3A 4A97A 2BG9A 4UXUA 2XYSA 4FRRA 4X5TA 5J5GA 3WTOA 5J5IA 4HQPA 3WTHA 3EHZA 3ZDHA 4ILCA 2BYRA 5HEOA 2WZYA 4TNVA 2WNJA 4ILBA 4ZZBA 3JAFA 4B5DA 5L4EA 3GUAA 2XQ4A 5SYOA 3WTJA 5HEGA 3EI0A 3RQWA 3UU4A 4AFHA 5KE4A 3U8KA 1UX2A 4NPPA 4QAAA 5AFNA 2BYQA 5CFBA 5KZUA 2UZ6A 2ZJVA 2WNLA 2ZJUA 2XNUA 5HEUA 5AFJA 3UQ7A 4A98A 4LMJA 2BYSA 3LSVA 3TLTA 3UU3A 4ZRUA 5J0ZA 4UM1A 4EZ1A 4IL4A 4AFTA 4QH4A 3RIFA 4IL9A 4ZJSA 1UW6A 4Z90A 5AFMB 4UM3S 3SQ6A 4ALXA 3T4MA 3UU6A 5AFKA 4IREA 2XQ8A 2XZ6A 2BG9C 2Y57A 3RIAA 4BQTA 2PGZA 4ZK4A 4HFEA 5HCJA 3IGQA 3PEOA 4UM3P 4COFA 4ZZCA 5J5FA 4NZBA 2XQ6A 4XK9A 3TLVA 2XQ5A 2C9TA 5BW2A 3SIOA 4UY2A 4ZK1A 3SQ9A 2X00D 2XQ7A 3WTIA 2BG9E 2BG9B 5AFHA 1UV6A 2WNCA 2YN6A 3EAMA 3U8MA 3U8JA 3WTKA 2W8FA 2Y7YA 2XQ9A 4UM3A 3TLUA 5HEJA 2XNVA 5HEHA 5IUXA 4Z91A 3P4WA 3U8NA 3WIPA 5AINA 4AFGA 2W8GA 3U8LA 2XQAA 2QC1B 2VL0A 2XNTA 3RHWA 4BFQA 3JAEA 5HCMA 5J5HA 2BJ0A 4HFCA 4DBMA 2BYPA 2Y54A 3C79A 4LMKA 4PIRA 5TVCA 2Y58A 5CO5A 3RQUA 3UUBA 3WTLA 2YOEA 2XYTA 5FJVA 5L4HA 3C84A 2X00A 4HFBA 2YKSA 2Y56A 4F8HA 5L47A 4TWDA 3SH1A 2BR7A 5LXBA 5AFLA 4HFDA 4ZJTA 2XZ5A 2YMEA 3ZKRA 5BP0A 4QABA 3P50A 2YMDA 5AFMA 2BR8A 3UU5A 4HFHA 5BRXA 4WV9A 2BYNA 4ILAA 3TLWA 4TWFA 3RI5A 4QACA 4QH1A 3UU8A 4TNWA 2WN9A 3TLSA 4D01A 4QH5A 5JMEA 4LMLA 4XHEA 3UQ4A 3WTMA 3WTNA 5LG3A 4TWHA 3JADA 4ZR6A 2PH9A 1I9BA 4HFIA
chains in the Genus database with same CATH superfamily
3ZDGA 3PMZA 2XQ3A 4A97A 2BG9A 4UXUA 2XYSA 4FRRA 4X5TA 5J5GA 3WTOA 5J5IA 4HQPA 3WTHA 3EHZA 3ZDHA 4ILCA 2BYRA 5HEOA 2WZYA 4TNVA 2WNJA 4ILBA 4ZZBA 3JAFA 4B5DA 5L4EA 3GUAA 2XQ4A 5SYOA 3WTJA 5HEGA 3EI0A 3RQWA 3UU4A 4AFHA 5KE4A 3U8KA 1UX2A 4NPPA 4QAAA 5AFNA 2BYQA 5CFBA 5KZUA 2UZ6A 2ZJVA 2WNLA 2ZJUA 2XNUA 5HEUA 5AFJA 3UQ7A 4A98A 4LMJA 2BYSA 3LSVA 3TLTA 3UU3A 4ZRUA 5J0ZA 4UM1A 4EZ1A 4IL4A 4AFTA 4QH4A 3RIFA 4IL9A 4ZJSA 1UW6A 4Z90A 5AFMB 4UM3S 3SQ6A 4ALXA 3T4MA 3UU6A 5AFKA 4IREA 2XQ8A 2XZ6A 2BG9C 2Y57A 3RIAA 4BQTA 2PGZA 4ZK4A 4HFEA 5HCJA 3IGQA 3PEOA 4UM3P 4COFA 4ZZCA 5J5FA 4NZBA 2XQ6A 4XK9A 3TLVA 2XQ5A 2C9TA 5BW2A 3SIOA 4UY2A 4ZK1A 3SQ9A 2X00D 2XQ7A 3WTIA 2BG9E 2BG9B 5AFHA 1UV6A 2WNCA 2YN6A 3EAMA 3U8MA 3U8JA 3WTKA 2W8FA 2Y7YA 2XQ9A 4UM3A 3TLUA 5HEJA 2XNVA 5HEHA 5IUXA 4Z91A 3P4WA 3U8NA 3WIPA 5AINA 4AFGA 2W8GA 3U8LA 2XQAA 2QC1B 2VL0A 2XNTA 3RHWA 4BFQA 3JAEA 5HCMA 5J5HA 2BJ0A 4HFCA 4DBMA 2BYPA 2Y54A 3C79A 4LMKA 4PIRA 5TVCA 2Y58A 5CO5A 3RQUA 3UUBA 3WTLA 2YOEA 2XYTA 5FJVA 5L4HA 3C84A 2X00A 4HFBA 2YKSA 2Y56A 4F8HA 5L47A 4TWDA 3SH1A 2BR7A 5LXBA 5AFLA 4HFDA 4ZJTA 2XZ5A 2YMEA 3ZKRA 5BP0A 4QABA 3P50A 2YMDA 5AFMA 2BR8A 3UU5A 4HFHA 5BRXA 4WV9A 2BYNA 4ILAA 3TLWA 4TWFA 3RI5A 4QACA 4QH1A 3UU8A 4TNWA 2WN9A 3TLSA 4D01A 4QH5A 5JMEA 4LMLA 4XHEA 3UQ4A 3WTMA 3WTNA 5LG3A 4TWHA 3JADA 4ZR6A 2PH9A 1I9BA 4HFIA
chains in the Genus database with same CATH topology
3ZDGA 3PMZA 2XQ3A 4A97A 2BG9A 4UXUA 2XYSA 4FRRA 4X5TA 5J5GA 3WTOA 5J5IA 4HQPA 3WTHA 3EHZA 3ZDHA 4ILCA 2BYRA 5HEOA 2WZYA 4TNVA 2WNJA 4ILBA 4ZZBA 3JAFA 4B5DA 5L4EA 3GUAA 2XQ4A 5SYOA 3WTJA 5HEGA 3EI0A 3RQWA 3UU4A 4AFHA 5KE4A 3U8KA 1UX2A 4NPPA 4QAAA 5AFNA 2BYQA 5CFBA 5KZUA 2UZ6A 2ZJVA 2WNLA 2ZJUA 2XNUA 5HEUA 5AFJA 3UQ7A 4A98A 4LMJA 2BYSA 3LSVA 3TLTA 3UU3A 4ZRUA 5J0ZA 4UM1A 4EZ1A 4IL4A 4AFTA 4QH4A 3RIFA 4IL9A 4ZJSA 1UW6A 4Z90A 5AFMB 4UM3S 3SQ6A 4ALXA 3T4MA 3UU6A 5AFKA 4IREA 2XQ8A 2XZ6A 2BG9C 2Y57A 3RIAA 4BQTA 2PGZA 4ZK4A 4HFEA 5HCJA 3IGQA 3PEOA 4UM3P 4COFA 4ZZCA 5J5FA 4NZBA 2XQ6A 4XK9A 3TLVA 2XQ5A 2C9TA 5BW2A 3SIOA 4UY2A 4ZK1A 3SQ9A 2X00D 2XQ7A 3WTIA 2BG9E 2BG9B 5AFHA 1UV6A 2WNCA 2YN6A 3EAMA 3U8MA 3U8JA 3WTKA 2W8FA 2Y7YA 2XQ9A 4UM3A 3TLUA 5HEJA 2XNVA 5HEHA 5IUXA 4Z91A 3P4WA 3U8NA 3WIPA 5AINA 4AFGA 2W8GA 3U8LA 2XQAA 2QC1B 2VL0A 2XNTA 3RHWA 4BFQA 3JAEA 5HCMA 5J5HA 2BJ0A 4HFCA 4DBMA 2BYPA 2Y54A 3C79A 4LMKA 4PIRA 5TVCA 2Y58A 5CO5A 3RQUA 3UUBA 3WTLA 2YOEA 2XYTA 5FJVA 5L4HA 3C84A 2X00A 4HFBA 2YKSA 2Y56A 4F8HA 5L47A 4TWDA 3SH1A 2BR7A 5LXBA 5AFLA 4HFDA 4ZJTA 2XZ5A 2YMEA 3ZKRA 5BP0A 4QABA 3P50A 2YMDA 5AFMA 2BR8A 3UU5A 4HFHA 5BRXA 4WV9A 2BYNA 4ILAA 3TLWA 4TWFA 3RI5A 4QACA 4QH1A 3UU8A 4TNWA 2WN9A 3TLSA 4D01A 4QH5A 5JMEA 4LMLA 4XHEA 3UQ4A 3WTMA 3WTNA 5LG3A 4TWHA 3JADA 4ZR6A 2PH9A 1I9BA 4HFIA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3ZDG A;  3PMZ A;  2XQ3 A;  4A97 A;  2BG9 A;  4UXU A;  2XYS A;  4FRR A;  4X5T A;  5J5G A;  3WTO A;  5J5I A;  4HQP A;  3WTH A;  3EHZ A;  3ZDH A;  4ILC A;  2BYR A;  5HEO A;  2WZY A;  4TNV A;  2WNJ A;  4ILB A;  4ZZB A;  3JAF A;  4B5D A;  5L4E A;  3GUA A;  2XQ4 A;  5SYO A;  3WTJ A;  5HEG A;  3EI0 A;  3RQW A;  3UU4 A;  4AFH A;  5KE4 A;  3U8K A;  1UX2 A;  4NPP A;  4QAA A;  5AFN A;  2BYQ A;  5CFB A;  5KZU A;  2UZ6 A;  2ZJV A;  2WNL A;  2ZJU A;  2XNU A;  5HEU A;  5AFJ A;  3UQ7 A;  4A98 A;  4LMJ A;  2BYS A;  3LSV A;  3TLT A;  3UU3 A;  4ZRU A;  5J0Z A;  4UM1 A;  4EZ1 A;  4IL4 A;  4AFT A;  4QH4 A;  3RIF A;  4IL9 A;  4ZJS A;  1UW6 A;  4Z90 A;  5AFM B;  4UM3 S;  3SQ6 A;  4ALX A;  3T4M A;  3UU6 A;  5AFK A;  4IRE A;  2XQ8 A;  2XZ6 A;  2BG9 C;  2Y57 A;  3RIA A;  4BQT A;  2PGZ A;  4ZK4 A;  4HFE A;  5HCJ A;  3IGQ A;  3PEO A;  4UM3 P;  4COF A;  4ZZC A;  5J5F A;  4NZB A;  2XQ6 A;  4XK9 A;  3TLV A;  2XQ5 A;  2C9T A;  5BW2 A;  3SIO A;  4UY2 A;  4ZK1 A;  3SQ9 A;  2X00 D;  2XQ7 A;  3WTI A;  2BG9 E;  2BG9 B;  5AFH A;  1UV6 A;  2WNC A;  2YN6 A;  3EAM A;  3U8M A;  3U8J A;  3WTK A;  2W8F A;  2Y7Y A;  2XQ9 A;  4UM3 A;  3TLU A;  5HEJ A;  2XNV A;  5HEH A;  5IUX A;  4Z91 A;  3P4W A;  3U8N A;  3WIP A;  5AIN A;  4AFG A;  2W8G A;  3U8L A;  2XQA A;  2QC1 B;  2VL0 A;  2XNT A;  3RHW A;  4BFQ A;  3JAE A;  5HCM A;  5J5H A;  2BJ0 A;  4HFC A;  4DBM A;  2BYP A;  2Y54 A;  3C79 A;  4LMK A;  4PIR A;  5TVC A;  2Y58 A;  5CO5 A;  3RQU A;  3UUB A;  3WTL A;  2YOE A;  2XYT A;  5FJV A;  5L4H A;  3C84 A;  2X00 A;  4HFB A;  2YKS A;  2Y56 A;  4F8H A;  5L47 A;  4TWD A;  3SH1 A;  2BR7 A;  5LXB A;  5AFL A;  4HFD A;  4ZJT A;  2XZ5 A;  2YME A;  3ZKR A;  5BP0 A;  4QAB A;  3P50 A;  2YMD A;  5AFM A;  2BR8 A;  3UU5 A;  4HFH A;  5BRX A;  4WV9 A;  2BYN A;  4ILA A;  3TLW A;  4TWF A;  3RI5 A;  4QAC A;  4QH1 A;  3UU8 A;  4TNW A;  2WN9 A;  3TLS A;  4D01 A;  4QH5 A;  5JME A;  4LML A;  4XHE A;  3UQ4 A;  3WTM A;  3WTN A;  5LG3 A;  4TWH A;  3JAD A;  4ZR6 A;  2PH9 A;  1I9B A;  4HFI A; 
#chains in the Genus database with same CATH topology
 3ZDG A;  3PMZ A;  2XQ3 A;  4A97 A;  2BG9 A;  4UXU A;  2XYS A;  4FRR A;  4X5T A;  5J5G A;  3WTO A;  5J5I A;  4HQP A;  3WTH A;  3EHZ A;  3ZDH A;  4ILC A;  2BYR A;  5HEO A;  2WZY A;  4TNV A;  2WNJ A;  4ILB A;  4ZZB A;  3JAF A;  4B5D A;  5L4E A;  3GUA A;  2XQ4 A;  5SYO A;  3WTJ A;  5HEG A;  3EI0 A;  3RQW A;  3UU4 A;  4AFH A;  5KE4 A;  3U8K A;  1UX2 A;  4NPP A;  4QAA A;  5AFN A;  2BYQ A;  5CFB A;  5KZU A;  2UZ6 A;  2ZJV A;  2WNL A;  2ZJU A;  2XNU A;  5HEU A;  5AFJ A;  3UQ7 A;  4A98 A;  4LMJ A;  2BYS A;  3LSV A;  3TLT A;  3UU3 A;  4ZRU A;  5J0Z A;  4UM1 A;  4EZ1 A;  4IL4 A;  4AFT A;  4QH4 A;  3RIF A;  4IL9 A;  4ZJS A;  1UW6 A;  4Z90 A;  5AFM B;  4UM3 S;  3SQ6 A;  4ALX A;  3T4M A;  3UU6 A;  5AFK A;  4IRE A;  2XQ8 A;  2XZ6 A;  2BG9 C;  2Y57 A;  3RIA A;  4BQT A;  2PGZ A;  4ZK4 A;  4HFE A;  5HCJ A;  3IGQ A;  3PEO A;  4UM3 P;  4COF A;  4ZZC A;  5J5F A;  4NZB A;  2XQ6 A;  4XK9 A;  3TLV A;  2XQ5 A;  2C9T A;  5BW2 A;  3SIO A;  4UY2 A;  4ZK1 A;  3SQ9 A;  2X00 D;  2XQ7 A;  3WTI A;  2BG9 E;  2BG9 B;  5AFH A;  1UV6 A;  2WNC A;  2YN6 A;  3EAM A;  3U8M A;  3U8J A;  3WTK A;  2W8F A;  2Y7Y A;  2XQ9 A;  4UM3 A;  3TLU A;  5HEJ A;  2XNV A;  5HEH A;  5IUX A;  4Z91 A;  3P4W A;  3U8N A;  3WIP A;  5AIN A;  4AFG A;  2W8G A;  3U8L A;  2XQA A;  2QC1 B;  2VL0 A;  2XNT A;  3RHW A;  4BFQ A;  3JAE A;  5HCM A;  5J5H A;  2BJ0 A;  4HFC A;  4DBM A;  2BYP A;  2Y54 A;  3C79 A;  4LMK A;  4PIR A;  5TVC A;  2Y58 A;  5CO5 A;  3RQU A;  3UUB A;  3WTL A;  2YOE A;  2XYT A;  5FJV A;  5L4H A;  3C84 A;  2X00 A;  4HFB A;  2YKS A;  2Y56 A;  4F8H A;  5L47 A;  4TWD A;  3SH1 A;  2BR7 A;  5LXB A;  5AFL A;  4HFD A;  4ZJT A;  2XZ5 A;  2YME A;  3ZKR A;  5BP0 A;  4QAB A;  3P50 A;  2YMD A;  5AFM A;  2BR8 A;  3UU5 A;  4HFH A;  5BRX A;  4WV9 A;  2BYN A;  4ILA A;  3TLW A;  4TWF A;  3RI5 A;  4QAC A;  4QH1 A;  3UU8 A;  4TNW A;  2WN9 A;  3TLS A;  4D01 A;  4QH5 A;  5JME A;  4LML A;  4XHE A;  3UQ4 A;  3WTM A;  3WTN A;  5LG3 A;  4TWH A;  3JAD A;  4ZR6 A;  2PH9 A;  1I9B A;  4HFI A; 
#chains in the Genus database with same CATH homology
 3ZDG A;  3PMZ A;  2XQ3 A;  4A97 A;  2BG9 A;  4UXU A;  2XYS A;  4FRR A;  4X5T A;  5J5G A;  3WTO A;  5J5I A;  4HQP A;  3WTH A;  3EHZ A;  3ZDH A;  4ILC A;  2BYR A;  5HEO A;  2WZY A;  4TNV A;  2WNJ A;  4ILB A;  4ZZB A;  3JAF A;  4B5D A;  5L4E A;  3GUA A;  2XQ4 A;  5SYO A;  3WTJ A;  5HEG A;  3EI0 A;  3RQW A;  3UU4 A;  4AFH A;  5KE4 A;  3U8K A;  1UX2 A;  4NPP A;  4QAA A;  5AFN A;  2BYQ A;  5CFB A;  5KZU A;  2UZ6 A;  2ZJV A;  2WNL A;  2ZJU A;  2XNU A;  5HEU A;  5AFJ A;  3UQ7 A;  4A98 A;  4LMJ A;  2BYS A;  3LSV A;  3TLT A;  3UU3 A;  4ZRU A;  5J0Z A;  4UM1 A;  4EZ1 A;  4IL4 A;  4AFT A;  4QH4 A;  3RIF A;  4IL9 A;  4ZJS A;  1UW6 A;  4Z90 A;  5AFM B;  4UM3 S;  3SQ6 A;  4ALX A;  3T4M A;  3UU6 A;  5AFK A;  4IRE A;  2XQ8 A;  2XZ6 A;  2BG9 C;  2Y57 A;  3RIA A;  4BQT A;  2PGZ A;  4ZK4 A;  4HFE A;  5HCJ A;  3IGQ A;  3PEO A;  4UM3 P;  4COF A;  4ZZC A;  5J5F A;  4NZB A;  2XQ6 A;  4XK9 A;  3TLV A;  2XQ5 A;  2C9T A;  5BW2 A;  3SIO A;  4UY2 A;  4ZK1 A;  3SQ9 A;  2X00 D;  2XQ7 A;  3WTI A;  2BG9 E;  2BG9 B;  5AFH A;  1UV6 A;  2WNC A;  2YN6 A;  3EAM A;  3U8M A;  3U8J A;  3WTK A;  2W8F A;  2Y7Y A;  2XQ9 A;  4UM3 A;  3TLU A;  5HEJ A;  2XNV A;  5HEH A;  5IUX A;  4Z91 A;  3P4W A;  3U8N A;  3WIP A;  5AIN A;  4AFG A;  2W8G A;  3U8L A;  2XQA A;  2QC1 B;  2VL0 A;  2XNT A;  3RHW A;  4BFQ A;  3JAE A;  5HCM A;  5J5H A;  2BJ0 A;  4HFC A;  4DBM A;  2BYP A;  2Y54 A;  3C79 A;  4LMK A;  4PIR A;  5TVC A;  2Y58 A;  5CO5 A;  3RQU A;  3UUB A;  3WTL A;  2YOE A;  2XYT A;  5FJV A;  5L4H A;  3C84 A;  2X00 A;  4HFB A;  2YKS A;  2Y56 A;  4F8H A;  5L47 A;  4TWD A;  3SH1 A;  2BR7 A;  5LXB A;  5AFL A;  4HFD A;  4ZJT A;  2XZ5 A;  2YME A;  3ZKR A;  5BP0 A;  4QAB A;  3P50 A;  2YMD A;  5AFM A;  2BR8 A;  3UU5 A;  4HFH A;  5BRX A;  4WV9 A;  2BYN A;  4ILA A;  3TLW A;  4TWF A;  3RI5 A;  4QAC A;  4QH1 A;  3UU8 A;  4TNW A;  2WN9 A;  3TLS A;  4D01 A;  4QH5 A;  5JME A;  4LML A;  4XHE A;  3UQ4 A;  3WTM A;  3WTN A;  5LG3 A;  4TWH A;  3JAD A;  4ZR6 A;  2PH9 A;  1I9B A;  4HFI A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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