5BRXA

X-ray crystal structure of aplysia californica (ac-achbp) in complex with 2-pyridyl azatricyclo[3.3.1.13,7]decane; 2-pyridylazaadamantane; 2-aza (ti-8480)
Total Genus 48
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
48
sequence length
211
structure length
209
Chain Sequence
DDKLHSQANLMRLKSDLFNRSYPGPTKDDPLTVTLGFTLQDIVKADSSTNEVDLVYWEQQRWKLNSLMWDPNEYGNITDFRTSAADIWTPDITAYSSTRPVQVLSPQIAVVTHDGSVMFIPAQRLSFMCDPTGVDSEEGATCAVKFGSWVYSGFEIDLKTDTDQVDLSSYYASSKYEILSATQTRQVQHYSCCPEPYIDVNLVVKFRER
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Comparisons of Binding Affinities for Neuronal Nicotinic Receptors (NNRs) and AChBPs
rcsb
molecule tags Acetylcholine binding protein
source organism Aplysia californica
molecule keywords Soluble acetylcholine receptor
total genus 48
structure length 209
sequence length 211
chains with identical sequence B, C, D, E, F, G, H, I, J
ec nomenclature
pdb deposition date 2015-06-01

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02931 Neur_chan_LBD Neurotransmitter-gated ion-channel ligand binding domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.170.10 Mainly Beta Distorted Sandwich Acetylcholine Binding Protein; Chain: A, Neurotransmitter-gated ion-channel ligand-binding domain 5brxA00
2BG9E 2X00D 4ILAA 4IREA 3UQ4A 5BRXA 5HEGA 4D01A 2XQ4A 5TVCA 3IGQA 3WTKA 4LMLA 4HQPA 2Y56A 4IL9A 2XNTA 5FJVA 4ILBA 3P4WA 4UXUA 5HCMA 5AFLA 4AFTA 5AFKA 2XQ7A 3WIPA 5J5IA 5HEOA 4HFHA 4TWHA 3JAFA 4DBMA 4ZJTA 5AFNA 2XQAA 4HFEA 5J0ZA 2XQ9A 3TLVA 1UX2A 4ZR6A 5BW2A 2BG9A 3ZDHA 3U8JA 5CO5A 5HEUA 4B5DA 3WTNA 2XQ8A 3WTHA 3WTLA 4ZZCA 5AFHA 2BYQA 3WTJA 3C84A 4Z90A 2YOEA 2BJ0A 4ZRUA 2XQ6A 2Y7YA 5KE4A 4UM3A 3WTIA 2BG9B 5SYOA 4HFBA 4WV9A 3UQ7A 5L4HA 3RIAA 3LSVA 3TLWA 3UU6A 2BR7A 4PIRA 2VL0A 2UZ6A 4HFDA 3TLSA 4F8HA 2ZJVA 4NPPA 4LMJA 3RQWA 4IL4A 5HEJA 3PEOA 2BG9C 3T4MA 5J5FA 2XNVA 2X00A 2YKSA 4FRRA 2Y54A 3JAEA 2WNCA 2XQ5A 5AFJA 5IUXA 4XK9A 2WZYA 5J5HA 4QH1A 2Y57A 5KZUA 3SIOA 4AFHA 4ZK4A 5J5GA 3TLTA 4ZZBA 3U8KA 3SQ6A 4UM1A 3WTMA 3JADA 1I9BA 4ZK1A 5HCJA 4QH5A 2PH9A 2WNLA 3P50A 5AINA 4UM3S 2W8FA 4XHEA 4HFCA 2BYNA 2XYSA 4EZ1A 2BR8A 2ZJUA 3EAMA 2WN9A 3UU3A 3EI0A 5L4EA 4NZBA 3ZKRA 2W8GA 2BYSA 3U8NA 4BQTA 2QC1B 3UU5A 3U8MA 3C79A 2XNUA 5LG3A 5AFMA 5CFBA 5L47A 2PGZA 4TWFA 4TNWA 4UY2A 2XYTA 5HEHA 3PMZA 5LXBA 1UW6A 3RHWA 4AFGA 3UUBA 4BFQA 3UU4A 5AFMB 3SH1A 3UU8A 5BP0A 2XZ6A 4ALXA 4A98A 2YN6A 2WNJA 4UM3P 4TNVA 4LMKA 4QAAA 4QH4A 4Z91A 3U8LA 4COFA 3SQ9A 4QABA 3EHZA 1UV6A 4TWDA 4ZJSA 3ZDGA 5JMEA 3TLUA 2YMEA 4ILCA 2Y58A 3GUAA 2XZ5A 2YMDA 4X5TA 3RIFA 2BYPA 3WTOA 3RQUA 2BYRA 4QACA 4HFIA 2C9TA 4A97A 2XQ3A 3RI5A
chains in the Genus database with same CATH superfamily
2BG9E 2X00D 4ILAA 4IREA 3UQ4A 5BRXA 5HEGA 4D01A 2XQ4A 5TVCA 3IGQA 3WTKA 4LMLA 4HQPA 2Y56A 4IL9A 2XNTA 5FJVA 4ILBA 3P4WA 4UXUA 5HCMA 5AFLA 4AFTA 5AFKA 2XQ7A 3WIPA 5J5IA 5HEOA 4HFHA 4TWHA 3JAFA 4DBMA 4ZJTA 5AFNA 2XQAA 4HFEA 5J0ZA 2XQ9A 3TLVA 1UX2A 4ZR6A 5BW2A 2BG9A 3ZDHA 3U8JA 5CO5A 5HEUA 4B5DA 3WTNA 2XQ8A 3WTHA 3WTLA 4ZZCA 5AFHA 2BYQA 3WTJA 3C84A 4Z90A 2YOEA 2BJ0A 4ZRUA 2XQ6A 2Y7YA 5KE4A 4UM3A 3WTIA 2BG9B 5SYOA 4HFBA 4WV9A 3UQ7A 5L4HA 3RIAA 3LSVA 3TLWA 3UU6A 2BR7A 4PIRA 2VL0A 2UZ6A 4HFDA 3TLSA 4F8HA 2ZJVA 4NPPA 4LMJA 3RQWA 4IL4A 5HEJA 3PEOA 2BG9C 3T4MA 5J5FA 2XNVA 2X00A 2YKSA 4FRRA 2Y54A 3JAEA 2WNCA 2XQ5A 5AFJA 5IUXA 4XK9A 2WZYA 5J5HA 4QH1A 2Y57A 5KZUA 3SIOA 4AFHA 4ZK4A 5J5GA 3TLTA 4ZZBA 3U8KA 3SQ6A 4UM1A 3WTMA 3JADA 1I9BA 4ZK1A 5HCJA 4QH5A 2PH9A 2WNLA 3P50A 5AINA 4UM3S 2W8FA 4XHEA 4HFCA 2BYNA 2XYSA 4EZ1A 2BR8A 2ZJUA 3EAMA 2WN9A 3UU3A 3EI0A 5L4EA 4NZBA 3ZKRA 2W8GA 2BYSA 3U8NA 4BQTA 2QC1B 3UU5A 3U8MA 3C79A 2XNUA 5LG3A 5AFMA 5CFBA 5L47A 2PGZA 4TWFA 4TNWA 4UY2A 2XYTA 5HEHA 3PMZA 5LXBA 1UW6A 3RHWA 4AFGA 3UUBA 4BFQA 3UU4A 5AFMB 3SH1A 3UU8A 5BP0A 2XZ6A 4ALXA 4A98A 2YN6A 2WNJA 4UM3P 4TNVA 4LMKA 4QAAA 4QH4A 4Z91A 3U8LA 4COFA 3SQ9A 4QABA 3EHZA 1UV6A 4TWDA 4ZJSA 3ZDGA 5JMEA 3TLUA 2YMEA 4ILCA 2Y58A 3GUAA 2XZ5A 2YMDA 4X5TA 3RIFA 2BYPA 3WTOA 3RQUA 2BYRA 4QACA 4HFIA 2C9TA 4A97A 2XQ3A 3RI5A
chains in the Genus database with same CATH topology
2BG9E 2X00D 4ILAA 4IREA 3UQ4A 5BRXA 5HEGA 4D01A 2XQ4A 5TVCA 3IGQA 3WTKA 4LMLA 4HQPA 2Y56A 4IL9A 2XNTA 5FJVA 4ILBA 3P4WA 4UXUA 5HCMA 5AFLA 4AFTA 5AFKA 2XQ7A 3WIPA 5J5IA 5HEOA 4HFHA 4TWHA 3JAFA 4DBMA 4ZJTA 5AFNA 2XQAA 4HFEA 5J0ZA 2XQ9A 3TLVA 1UX2A 4ZR6A 5BW2A 2BG9A 3ZDHA 3U8JA 5CO5A 5HEUA 4B5DA 3WTNA 2XQ8A 3WTHA 3WTLA 4ZZCA 5AFHA 2BYQA 3WTJA 3C84A 4Z90A 2YOEA 2BJ0A 4ZRUA 2XQ6A 2Y7YA 5KE4A 4UM3A 3WTIA 2BG9B 5SYOA 4HFBA 4WV9A 3UQ7A 5L4HA 3RIAA 3LSVA 3TLWA 3UU6A 2BR7A 4PIRA 2VL0A 2UZ6A 4HFDA 3TLSA 4F8HA 2ZJVA 4NPPA 4LMJA 3RQWA 4IL4A 5HEJA 3PEOA 2BG9C 3T4MA 5J5FA 2XNVA 2X00A 2YKSA 4FRRA 2Y54A 3JAEA 2WNCA 2XQ5A 5AFJA 5IUXA 4XK9A 2WZYA 5J5HA 4QH1A 2Y57A 5KZUA 3SIOA 4AFHA 4ZK4A 5J5GA 3TLTA 4ZZBA 3U8KA 3SQ6A 4UM1A 3WTMA 3JADA 1I9BA 4ZK1A 5HCJA 4QH5A 2PH9A 2WNLA 3P50A 5AINA 4UM3S 2W8FA 4XHEA 4HFCA 2BYNA 2XYSA 4EZ1A 2BR8A 2ZJUA 3EAMA 2WN9A 3UU3A 3EI0A 5L4EA 4NZBA 3ZKRA 2W8GA 2BYSA 3U8NA 4BQTA 2QC1B 3UU5A 3U8MA 3C79A 2XNUA 5LG3A 5AFMA 5CFBA 5L47A 2PGZA 4TWFA 4TNWA 4UY2A 2XYTA 5HEHA 3PMZA 5LXBA 1UW6A 3RHWA 4AFGA 3UUBA 4BFQA 3UU4A 5AFMB 3SH1A 3UU8A 5BP0A 2XZ6A 4ALXA 4A98A 2YN6A 2WNJA 4UM3P 4TNVA 4LMKA 4QAAA 4QH4A 4Z91A 3U8LA 4COFA 3SQ9A 4QABA 3EHZA 1UV6A 4TWDA 4ZJSA 3ZDGA 5JMEA 3TLUA 2YMEA 4ILCA 2Y58A 3GUAA 2XZ5A 2YMDA 4X5TA 3RIFA 2BYPA 3WTOA 3RQUA 2BYRA 4QACA 4HFIA 2C9TA 4A97A 2XQ3A 3RI5A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2BG9 E;  2X00 D;  4ILA A;  4IRE A;  3UQ4 A;  5BRX A;  5HEG A;  4D01 A;  2XQ4 A;  5TVC A;  3IGQ A;  3WTK A;  4LML A;  4HQP A;  2Y56 A;  4IL9 A;  2XNT A;  5FJV A;  4ILB A;  3P4W A;  4UXU A;  5HCM A;  5AFL A;  4AFT A;  5AFK A;  2XQ7 A;  3WIP A;  5J5I A;  5HEO A;  4HFH A;  4TWH A;  3JAF A;  4DBM A;  4ZJT A;  5AFN A;  2XQA A;  4HFE A;  5J0Z A;  2XQ9 A;  3TLV A;  1UX2 A;  4ZR6 A;  5BW2 A;  2BG9 A;  3ZDH A;  3U8J A;  5CO5 A;  5HEU A;  4B5D A;  3WTN A;  2XQ8 A;  3WTH A;  3WTL A;  4ZZC A;  5AFH A;  2BYQ A;  3WTJ A;  3C84 A;  4Z90 A;  2YOE A;  2BJ0 A;  4ZRU A;  2XQ6 A;  2Y7Y A;  5KE4 A;  4UM3 A;  3WTI A;  2BG9 B;  5SYO A;  4HFB A;  4WV9 A;  3UQ7 A;  5L4H A;  3RIA A;  3LSV A;  3TLW A;  3UU6 A;  2BR7 A;  4PIR A;  2VL0 A;  2UZ6 A;  4HFD A;  3TLS A;  4F8H A;  2ZJV A;  4NPP A;  4LMJ A;  3RQW A;  4IL4 A;  5HEJ A;  3PEO A;  2BG9 C;  3T4M A;  5J5F A;  2XNV A;  2X00 A;  2YKS A;  4FRR A;  2Y54 A;  3JAE A;  2WNC A;  2XQ5 A;  5AFJ A;  5IUX A;  4XK9 A;  2WZY A;  5J5H A;  4QH1 A;  2Y57 A;  5KZU A;  3SIO A;  4AFH A;  4ZK4 A;  5J5G A;  3TLT A;  4ZZB A;  3U8K A;  3SQ6 A;  4UM1 A;  3WTM A;  3JAD A;  1I9B A;  4ZK1 A;  5HCJ A;  4QH5 A;  2PH9 A;  2WNL A;  3P50 A;  5AIN A;  4UM3 S;  2W8F A;  4XHE A;  4HFC A;  2BYN A;  2XYS A;  4EZ1 A;  2BR8 A;  2ZJU A;  3EAM A;  2WN9 A;  3UU3 A;  3EI0 A;  5L4E A;  4NZB A;  3ZKR A;  2W8G A;  2BYS A;  3U8N A;  4BQT A;  2QC1 B;  3UU5 A;  3U8M A;  3C79 A;  2XNU A;  5LG3 A;  5AFM A;  5CFB A;  5L47 A;  2PGZ A;  4TWF A;  4TNW A;  4UY2 A;  2XYT A;  5HEH A;  3PMZ A;  5LXB A;  1UW6 A;  3RHW A;  4AFG A;  3UUB A;  4BFQ A;  3UU4 A;  5AFM B;  3SH1 A;  3UU8 A;  5BP0 A;  2XZ6 A;  4ALX A;  4A98 A;  2YN6 A;  2WNJ A;  4UM3 P;  4TNV A;  4LMK A;  4QAA A;  4QH4 A;  4Z91 A;  3U8L A;  4COF A;  3SQ9 A;  4QAB A;  3EHZ A;  1UV6 A;  4TWD A;  4ZJS A;  3ZDG A;  5JME A;  3TLU A;  2YME A;  4ILC A;  2Y58 A;  3GUA A;  2XZ5 A;  2YMD A;  4X5T A;  3RIF A;  2BYP A;  3WTO A;  3RQU A;  2BYR A;  4QAC A;  4HFI A;  2C9T A;  4A97 A;  2XQ3 A;  3RI5 A; 
#chains in the Genus database with same CATH topology
 2BG9 E;  2X00 D;  4ILA A;  4IRE A;  3UQ4 A;  5BRX A;  5HEG A;  4D01 A;  2XQ4 A;  5TVC A;  3IGQ A;  3WTK A;  4LML A;  4HQP A;  2Y56 A;  4IL9 A;  2XNT A;  5FJV A;  4ILB A;  3P4W A;  4UXU A;  5HCM A;  5AFL A;  4AFT A;  5AFK A;  2XQ7 A;  3WIP A;  5J5I A;  5HEO A;  4HFH A;  4TWH A;  3JAF A;  4DBM A;  4ZJT A;  5AFN A;  2XQA A;  4HFE A;  5J0Z A;  2XQ9 A;  3TLV A;  1UX2 A;  4ZR6 A;  5BW2 A;  2BG9 A;  3ZDH A;  3U8J A;  5CO5 A;  5HEU A;  4B5D A;  3WTN A;  2XQ8 A;  3WTH A;  3WTL A;  4ZZC A;  5AFH A;  2BYQ A;  3WTJ A;  3C84 A;  4Z90 A;  2YOE A;  2BJ0 A;  4ZRU A;  2XQ6 A;  2Y7Y A;  5KE4 A;  4UM3 A;  3WTI A;  2BG9 B;  5SYO A;  4HFB A;  4WV9 A;  3UQ7 A;  5L4H A;  3RIA A;  3LSV A;  3TLW A;  3UU6 A;  2BR7 A;  4PIR A;  2VL0 A;  2UZ6 A;  4HFD A;  3TLS A;  4F8H A;  2ZJV A;  4NPP A;  4LMJ A;  3RQW A;  4IL4 A;  5HEJ A;  3PEO A;  2BG9 C;  3T4M A;  5J5F A;  2XNV A;  2X00 A;  2YKS A;  4FRR A;  2Y54 A;  3JAE A;  2WNC A;  2XQ5 A;  5AFJ A;  5IUX A;  4XK9 A;  2WZY A;  5J5H A;  4QH1 A;  2Y57 A;  5KZU A;  3SIO A;  4AFH A;  4ZK4 A;  5J5G A;  3TLT A;  4ZZB A;  3U8K A;  3SQ6 A;  4UM1 A;  3WTM A;  3JAD A;  1I9B A;  4ZK1 A;  5HCJ A;  4QH5 A;  2PH9 A;  2WNL A;  3P50 A;  5AIN A;  4UM3 S;  2W8F A;  4XHE A;  4HFC A;  2BYN A;  2XYS A;  4EZ1 A;  2BR8 A;  2ZJU A;  3EAM A;  2WN9 A;  3UU3 A;  3EI0 A;  5L4E A;  4NZB A;  3ZKR A;  2W8G A;  2BYS A;  3U8N A;  4BQT A;  2QC1 B;  3UU5 A;  3U8M A;  3C79 A;  2XNU A;  5LG3 A;  5AFM A;  5CFB A;  5L47 A;  2PGZ A;  4TWF A;  4TNW A;  4UY2 A;  2XYT A;  5HEH A;  3PMZ A;  5LXB A;  1UW6 A;  3RHW A;  4AFG A;  3UUB A;  4BFQ A;  3UU4 A;  5AFM B;  3SH1 A;  3UU8 A;  5BP0 A;  2XZ6 A;  4ALX A;  4A98 A;  2YN6 A;  2WNJ A;  4UM3 P;  4TNV A;  4LMK A;  4QAA A;  4QH4 A;  4Z91 A;  3U8L A;  4COF A;  3SQ9 A;  4QAB A;  3EHZ A;  1UV6 A;  4TWD A;  4ZJS A;  3ZDG A;  5JME A;  3TLU A;  2YME A;  4ILC A;  2Y58 A;  3GUA A;  2XZ5 A;  2YMD A;  4X5T A;  3RIF A;  2BYP A;  3WTO A;  3RQU A;  2BYR A;  4QAC A;  4HFI A;  2C9T A;  4A97 A;  2XQ3 A;  3RI5 A; 
#chains in the Genus database with same CATH homology
 2BG9 E;  2X00 D;  4ILA A;  4IRE A;  3UQ4 A;  5BRX A;  5HEG A;  4D01 A;  2XQ4 A;  5TVC A;  3IGQ A;  3WTK A;  4LML A;  4HQP A;  2Y56 A;  4IL9 A;  2XNT A;  5FJV A;  4ILB A;  3P4W A;  4UXU A;  5HCM A;  5AFL A;  4AFT A;  5AFK A;  2XQ7 A;  3WIP A;  5J5I A;  5HEO A;  4HFH A;  4TWH A;  3JAF A;  4DBM A;  4ZJT A;  5AFN A;  2XQA A;  4HFE A;  5J0Z A;  2XQ9 A;  3TLV A;  1UX2 A;  4ZR6 A;  5BW2 A;  2BG9 A;  3ZDH A;  3U8J A;  5CO5 A;  5HEU A;  4B5D A;  3WTN A;  2XQ8 A;  3WTH A;  3WTL A;  4ZZC A;  5AFH A;  2BYQ A;  3WTJ A;  3C84 A;  4Z90 A;  2YOE A;  2BJ0 A;  4ZRU A;  2XQ6 A;  2Y7Y A;  5KE4 A;  4UM3 A;  3WTI A;  2BG9 B;  5SYO A;  4HFB A;  4WV9 A;  3UQ7 A;  5L4H A;  3RIA A;  3LSV A;  3TLW A;  3UU6 A;  2BR7 A;  4PIR A;  2VL0 A;  2UZ6 A;  4HFD A;  3TLS A;  4F8H A;  2ZJV A;  4NPP A;  4LMJ A;  3RQW A;  4IL4 A;  5HEJ A;  3PEO A;  2BG9 C;  3T4M A;  5J5F A;  2XNV A;  2X00 A;  2YKS A;  4FRR A;  2Y54 A;  3JAE A;  2WNC A;  2XQ5 A;  5AFJ A;  5IUX A;  4XK9 A;  2WZY A;  5J5H A;  4QH1 A;  2Y57 A;  5KZU A;  3SIO A;  4AFH A;  4ZK4 A;  5J5G A;  3TLT A;  4ZZB A;  3U8K A;  3SQ6 A;  4UM1 A;  3WTM A;  3JAD A;  1I9B A;  4ZK1 A;  5HCJ A;  4QH5 A;  2PH9 A;  2WNL A;  3P50 A;  5AIN A;  4UM3 S;  2W8F A;  4XHE A;  4HFC A;  2BYN A;  2XYS A;  4EZ1 A;  2BR8 A;  2ZJU A;  3EAM A;  2WN9 A;  3UU3 A;  3EI0 A;  5L4E A;  4NZB A;  3ZKR A;  2W8G A;  2BYS A;  3U8N A;  4BQT A;  2QC1 B;  3UU5 A;  3U8M A;  3C79 A;  2XNU A;  5LG3 A;  5AFM A;  5CFB A;  5L47 A;  2PGZ A;  4TWF A;  4TNW A;  4UY2 A;  2XYT A;  5HEH A;  3PMZ A;  5LXB A;  1UW6 A;  3RHW A;  4AFG A;  3UUB A;  4BFQ A;  3UU4 A;  5AFM B;  3SH1 A;  3UU8 A;  5BP0 A;  2XZ6 A;  4ALX A;  4A98 A;  2YN6 A;  2WNJ A;  4UM3 P;  4TNV A;  4LMK A;  4QAA A;  4QH4 A;  4Z91 A;  3U8L A;  4COF A;  3SQ9 A;  4QAB A;  3EHZ A;  1UV6 A;  4TWD A;  4ZJS A;  3ZDG A;  5JME A;  3TLU A;  2YME A;  4ILC A;  2Y58 A;  3GUA A;  2XZ5 A;  2YMD A;  4X5T A;  3RIF A;  2BYP A;  3WTO A;  3RQU A;  2BYR A;  4QAC A;  4HFI A;  2C9T A;  4A97 A;  2XQ3 A;  3RI5 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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