4QACA

X-ray structure of acetylcholine binding protein (achbp) in complex with 4-(4-methylpiperidin-1-yl)-6-(4-(trifluoromethyl)phenyl)pyrimidin-2-amine
Total Genus 52
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
52
sequence length
213
structure length
209
Chain Sequence
DYKDDDDKLDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLARVVSDGEVLYMPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTDDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title Structural basis for cooperative interactions of substituted 2-aminopyrimidines with the acetylcholine binding protein.
pubmed doi rcsb
molecule keywords Acetylcholine-binding protein
molecule tags Acetylcholine-binding protein
source organism Lymnaea stagnalis
total genus 52
structure length 209
sequence length 213
chains with identical sequence B, C, D, E, F, G, H, I, J
ec nomenclature
pdb deposition date 2014-05-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02931 Neur_chan_LBD Neurotransmitter-gated ion-channel ligand binding domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.170.10 Mainly Beta Distorted Sandwich Acetylcholine Binding Protein; Chain: A, Neurotransmitter-gated ion-channel ligand-binding domain 4qacA00
3PMZA 4XHEA 4HFEA 2YKSA 4NPPA 3WTOA 5AFNA 5L47A 3ZKRA 4ZK4A 3U8MA 5J5IA 2ZJVA 2XQAA 2XYSA 2YOEA 3RI5A 5L4HA 3TLVA 5L4EA 5AFLA 4UY2A 2BYSA 3JAEA 4DBMA 2BG9B 4HFDA 3GUAA 5HEUA 4ZK1A 4IL9A 4Z90A 5BW2A 2BYPA 2YN6A 2BYQA 4HFHA 5J5FA 2X00A 5TVCA 3U8KA 4QACA 2Y57A 2C9TA 2WNLA 4TWDA 2XQ7A 1I9BA 2BYRA 2YMEA 2XQ6A 3U8LA 3UU4A 3IGQA 3RHWA 4A98A 3RQUA 4QH1A 5IUXA 4ALXA 4Z91A 2BG9C 4ILBA 3WIPA 2Y54A 2YMDA 5CO5A 2XNTA 4ILCA 5AFKA 4UM3A 4PIRA 4HFIA 3RIAA 3UU5A 4ZZCA 4XK9A 4ZR6A 5SYOA 2W8GA 5HEJA 2PGZA 4UXUA 5J5GA 5J5HA 3TLSA 4UM1A 3WTMA 5BP0A 3EAMA 5HCMA 2BR8A 5LXBA 4NZBA 2XQ8A 3ZDGA 4B5DA 2XQ9A 3P50A 3PEOA 4F8HA 4COFA 4AFHA 3RIFA 5LG3A 2Y58A 3WTLA 3UQ7A 4HFBA 3SH1A 2QC1B 1UX2A 3P4WA 4ZRUA 4A97A 5AFHA 3LSVA 5FJVA 4ZJTA 3JADA 5AFJA 3UU6A 5J0ZA 2BG9A 3WTNA 5AFMA 2XZ5A 5HEGA 3TLUA 4BQTA 3EI0A 3RQWA 3ZDHA 3TLTA 2BR7A 4FRRA 3WTJA 3WTKA 2BJ0A 4AFTA 2W8FA 5HEOA 4TWHA 4AFGA 2BG9E 5AINA 3WTIA 5HEHA 4QAAA 5JMEA 4ILAA 5BRXA 2WN9A 4D01A 5CFBA 4IREA 2UZ6A 2VL0A 2WNCA 4QABA 4WV9A 2WNJA 4TWFA 2XYTA 5HCJA 3UQ4A 4EZ1A 5KE4A 4X5TA 4IL4A 4QH4A 1UV6A 4TNWA 2XNVA 3EHZA 2Y7YA 3C84A 4ZJSA 2XZ6A 4QH5A 3U8NA 3C79A 2WZYA 2X00D 4HQPA 4UM3S 4ZZBA 4UM3P 5KZUA 3SQ9A 2BYNA 2PH9A 3SIOA 5AFMB 4LMKA 2XQ3A 2XQ4A 4TNVA 2XQ5A 3UUBA 4LMJA 3UU8A 4HFCA 1UW6A 3T4MA 3U8JA 4BFQA 2XNUA 3WTHA 2ZJUA 2Y56A 3SQ6A 3UU3A 3JAFA 4LMLA 3TLWA
chains in the Genus database with same CATH superfamily
3PMZA 4XHEA 4HFEA 2YKSA 4NPPA 3WTOA 5AFNA 5L47A 3ZKRA 4ZK4A 3U8MA 5J5IA 2ZJVA 2XQAA 2XYSA 2YOEA 3RI5A 5L4HA 3TLVA 5L4EA 5AFLA 4UY2A 2BYSA 3JAEA 4DBMA 2BG9B 4HFDA 3GUAA 5HEUA 4ZK1A 4IL9A 4Z90A 5BW2A 2BYPA 2YN6A 2BYQA 4HFHA 5J5FA 2X00A 5TVCA 3U8KA 4QACA 2Y57A 2C9TA 2WNLA 4TWDA 2XQ7A 1I9BA 2BYRA 2YMEA 2XQ6A 3U8LA 3UU4A 3IGQA 3RHWA 4A98A 3RQUA 4QH1A 5IUXA 4ALXA 4Z91A 2BG9C 4ILBA 3WIPA 2Y54A 2YMDA 5CO5A 2XNTA 4ILCA 5AFKA 4UM3A 4PIRA 4HFIA 3RIAA 3UU5A 4ZZCA 4XK9A 4ZR6A 5SYOA 2W8GA 5HEJA 2PGZA 4UXUA 5J5GA 5J5HA 3TLSA 4UM1A 3WTMA 5BP0A 3EAMA 5HCMA 2BR8A 5LXBA 4NZBA 2XQ8A 3ZDGA 4B5DA 2XQ9A 3P50A 3PEOA 4F8HA 4COFA 4AFHA 3RIFA 5LG3A 2Y58A 3WTLA 3UQ7A 4HFBA 3SH1A 2QC1B 1UX2A 3P4WA 4ZRUA 4A97A 5AFHA 3LSVA 5FJVA 4ZJTA 3JADA 5AFJA 3UU6A 5J0ZA 2BG9A 3WTNA 5AFMA 2XZ5A 5HEGA 3TLUA 4BQTA 3EI0A 3RQWA 3ZDHA 3TLTA 2BR7A 4FRRA 3WTJA 3WTKA 2BJ0A 4AFTA 2W8FA 5HEOA 4TWHA 4AFGA 2BG9E 5AINA 3WTIA 5HEHA 4QAAA 5JMEA 4ILAA 5BRXA 2WN9A 4D01A 5CFBA 4IREA 2UZ6A 2VL0A 2WNCA 4QABA 4WV9A 2WNJA 4TWFA 2XYTA 5HCJA 3UQ4A 4EZ1A 5KE4A 4X5TA 4IL4A 4QH4A 1UV6A 4TNWA 2XNVA 3EHZA 2Y7YA 3C84A 4ZJSA 2XZ6A 4QH5A 3U8NA 3C79A 2WZYA 2X00D 4HQPA 4UM3S 4ZZBA 4UM3P 5KZUA 3SQ9A 2BYNA 2PH9A 3SIOA 5AFMB 4LMKA 2XQ3A 2XQ4A 4TNVA 2XQ5A 3UUBA 4LMJA 3UU8A 4HFCA 1UW6A 3T4MA 3U8JA 4BFQA 2XNUA 3WTHA 2ZJUA 2Y56A 3SQ6A 3UU3A 3JAFA 4LMLA 3TLWA
chains in the Genus database with same CATH topology
3PMZA 4XHEA 4HFEA 2YKSA 4NPPA 3WTOA 5AFNA 5L47A 3ZKRA 4ZK4A 3U8MA 5J5IA 2ZJVA 2XQAA 2XYSA 2YOEA 3RI5A 5L4HA 3TLVA 5L4EA 5AFLA 4UY2A 2BYSA 3JAEA 4DBMA 2BG9B 4HFDA 3GUAA 5HEUA 4ZK1A 4IL9A 4Z90A 5BW2A 2BYPA 2YN6A 2BYQA 4HFHA 5J5FA 2X00A 5TVCA 3U8KA 4QACA 2Y57A 2C9TA 2WNLA 4TWDA 2XQ7A 1I9BA 2BYRA 2YMEA 2XQ6A 3U8LA 3UU4A 3IGQA 3RHWA 4A98A 3RQUA 4QH1A 5IUXA 4ALXA 4Z91A 2BG9C 4ILBA 3WIPA 2Y54A 2YMDA 5CO5A 2XNTA 4ILCA 5AFKA 4UM3A 4PIRA 4HFIA 3RIAA 3UU5A 4ZZCA 4XK9A 4ZR6A 5SYOA 2W8GA 5HEJA 2PGZA 4UXUA 5J5GA 5J5HA 3TLSA 4UM1A 3WTMA 5BP0A 3EAMA 5HCMA 2BR8A 5LXBA 4NZBA 2XQ8A 3ZDGA 4B5DA 2XQ9A 3P50A 3PEOA 4F8HA 4COFA 4AFHA 3RIFA 5LG3A 2Y58A 3WTLA 3UQ7A 4HFBA 3SH1A 2QC1B 1UX2A 3P4WA 4ZRUA 4A97A 5AFHA 3LSVA 5FJVA 4ZJTA 3JADA 5AFJA 3UU6A 5J0ZA 2BG9A 3WTNA 5AFMA 2XZ5A 5HEGA 3TLUA 4BQTA 3EI0A 3RQWA 3ZDHA 3TLTA 2BR7A 4FRRA 3WTJA 3WTKA 2BJ0A 4AFTA 2W8FA 5HEOA 4TWHA 4AFGA 2BG9E 5AINA 3WTIA 5HEHA 4QAAA 5JMEA 4ILAA 5BRXA 2WN9A 4D01A 5CFBA 4IREA 2UZ6A 2VL0A 2WNCA 4QABA 4WV9A 2WNJA 4TWFA 2XYTA 5HCJA 3UQ4A 4EZ1A 5KE4A 4X5TA 4IL4A 4QH4A 1UV6A 4TNWA 2XNVA 3EHZA 2Y7YA 3C84A 4ZJSA 2XZ6A 4QH5A 3U8NA 3C79A 2WZYA 2X00D 4HQPA 4UM3S 4ZZBA 4UM3P 5KZUA 3SQ9A 2BYNA 2PH9A 3SIOA 5AFMB 4LMKA 2XQ3A 2XQ4A 4TNVA 2XQ5A 3UUBA 4LMJA 3UU8A 4HFCA 1UW6A 3T4MA 3U8JA 4BFQA 2XNUA 3WTHA 2ZJUA 2Y56A 3SQ6A 3UU3A 3JAFA 4LMLA 3TLWA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3PMZ A;  4XHE A;  4HFE A;  2YKS A;  4NPP A;  3WTO A;  5AFN A;  5L47 A;  3ZKR A;  4ZK4 A;  3U8M A;  5J5I A;  2ZJV A;  2XQA A;  2XYS A;  2YOE A;  3RI5 A;  5L4H A;  3TLV A;  5L4E A;  5AFL A;  4UY2 A;  2BYS A;  3JAE A;  4DBM A;  2BG9 B;  4HFD A;  3GUA A;  5HEU A;  4ZK1 A;  4IL9 A;  4Z90 A;  5BW2 A;  2BYP A;  2YN6 A;  2BYQ A;  4HFH A;  5J5F A;  2X00 A;  5TVC A;  3U8K A;  4QAC A;  2Y57 A;  2C9T A;  2WNL A;  4TWD A;  2XQ7 A;  1I9B A;  2BYR A;  2YME A;  2XQ6 A;  3U8L A;  3UU4 A;  3IGQ A;  3RHW A;  4A98 A;  3RQU A;  4QH1 A;  5IUX A;  4ALX A;  4Z91 A;  2BG9 C;  4ILB A;  3WIP A;  2Y54 A;  2YMD A;  5CO5 A;  2XNT A;  4ILC A;  5AFK A;  4UM3 A;  4PIR A;  4HFI A;  3RIA A;  3UU5 A;  4ZZC A;  4XK9 A;  4ZR6 A;  5SYO A;  2W8G A;  5HEJ A;  2PGZ A;  4UXU A;  5J5G A;  5J5H A;  3TLS A;  4UM1 A;  3WTM A;  5BP0 A;  3EAM A;  5HCM A;  2BR8 A;  5LXB A;  4NZB A;  2XQ8 A;  3ZDG A;  4B5D A;  2XQ9 A;  3P50 A;  3PEO A;  4F8H A;  4COF A;  4AFH A;  3RIF A;  5LG3 A;  2Y58 A;  3WTL A;  3UQ7 A;  4HFB A;  3SH1 A;  2QC1 B;  1UX2 A;  3P4W A;  4ZRU A;  4A97 A;  5AFH A;  3LSV A;  5FJV A;  4ZJT A;  3JAD A;  5AFJ A;  3UU6 A;  5J0Z A;  2BG9 A;  3WTN A;  5AFM A;  2XZ5 A;  5HEG A;  3TLU A;  4BQT A;  3EI0 A;  3RQW A;  3ZDH A;  3TLT A;  2BR7 A;  4FRR A;  3WTJ A;  3WTK A;  2BJ0 A;  4AFT A;  2W8F A;  5HEO A;  4TWH A;  4AFG A;  2BG9 E;  5AIN A;  3WTI A;  5HEH A;  4QAA A;  5JME A;  4ILA A;  5BRX A;  2WN9 A;  4D01 A;  5CFB A;  4IRE A;  2UZ6 A;  2VL0 A;  2WNC A;  4QAB A;  4WV9 A;  2WNJ A;  4TWF A;  2XYT A;  5HCJ A;  3UQ4 A;  4EZ1 A;  5KE4 A;  4X5T A;  4IL4 A;  4QH4 A;  1UV6 A;  4TNW A;  2XNV A;  3EHZ A;  2Y7Y A;  3C84 A;  4ZJS A;  2XZ6 A;  4QH5 A;  3U8N A;  3C79 A;  2WZY A;  2X00 D;  4HQP A;  4UM3 S;  4ZZB A;  4UM3 P;  5KZU A;  3SQ9 A;  2BYN A;  2PH9 A;  3SIO A;  5AFM B;  4LMK A;  2XQ3 A;  2XQ4 A;  4TNV A;  2XQ5 A;  3UUB A;  4LMJ A;  3UU8 A;  4HFC A;  1UW6 A;  3T4M A;  3U8J A;  4BFQ A;  2XNU A;  3WTH A;  2ZJU A;  2Y56 A;  3SQ6 A;  3UU3 A;  3JAF A;  4LML A;  3TLW A; 
#chains in the Genus database with same CATH topology
 3PMZ A;  4XHE A;  4HFE A;  2YKS A;  4NPP A;  3WTO A;  5AFN A;  5L47 A;  3ZKR A;  4ZK4 A;  3U8M A;  5J5I A;  2ZJV A;  2XQA A;  2XYS A;  2YOE A;  3RI5 A;  5L4H A;  3TLV A;  5L4E A;  5AFL A;  4UY2 A;  2BYS A;  3JAE A;  4DBM A;  2BG9 B;  4HFD A;  3GUA A;  5HEU A;  4ZK1 A;  4IL9 A;  4Z90 A;  5BW2 A;  2BYP A;  2YN6 A;  2BYQ A;  4HFH A;  5J5F A;  2X00 A;  5TVC A;  3U8K A;  4QAC A;  2Y57 A;  2C9T A;  2WNL A;  4TWD A;  2XQ7 A;  1I9B A;  2BYR A;  2YME A;  2XQ6 A;  3U8L A;  3UU4 A;  3IGQ A;  3RHW A;  4A98 A;  3RQU A;  4QH1 A;  5IUX A;  4ALX A;  4Z91 A;  2BG9 C;  4ILB A;  3WIP A;  2Y54 A;  2YMD A;  5CO5 A;  2XNT A;  4ILC A;  5AFK A;  4UM3 A;  4PIR A;  4HFI A;  3RIA A;  3UU5 A;  4ZZC A;  4XK9 A;  4ZR6 A;  5SYO A;  2W8G A;  5HEJ A;  2PGZ A;  4UXU A;  5J5G A;  5J5H A;  3TLS A;  4UM1 A;  3WTM A;  5BP0 A;  3EAM A;  5HCM A;  2BR8 A;  5LXB A;  4NZB A;  2XQ8 A;  3ZDG A;  4B5D A;  2XQ9 A;  3P50 A;  3PEO A;  4F8H A;  4COF A;  4AFH A;  3RIF A;  5LG3 A;  2Y58 A;  3WTL A;  3UQ7 A;  4HFB A;  3SH1 A;  2QC1 B;  1UX2 A;  3P4W A;  4ZRU A;  4A97 A;  5AFH A;  3LSV A;  5FJV A;  4ZJT A;  3JAD A;  5AFJ A;  3UU6 A;  5J0Z A;  2BG9 A;  3WTN A;  5AFM A;  2XZ5 A;  5HEG A;  3TLU A;  4BQT A;  3EI0 A;  3RQW A;  3ZDH A;  3TLT A;  2BR7 A;  4FRR A;  3WTJ A;  3WTK A;  2BJ0 A;  4AFT A;  2W8F A;  5HEO A;  4TWH A;  4AFG A;  2BG9 E;  5AIN A;  3WTI A;  5HEH A;  4QAA A;  5JME A;  4ILA A;  5BRX A;  2WN9 A;  4D01 A;  5CFB A;  4IRE A;  2UZ6 A;  2VL0 A;  2WNC A;  4QAB A;  4WV9 A;  2WNJ A;  4TWF A;  2XYT A;  5HCJ A;  3UQ4 A;  4EZ1 A;  5KE4 A;  4X5T A;  4IL4 A;  4QH4 A;  1UV6 A;  4TNW A;  2XNV A;  3EHZ A;  2Y7Y A;  3C84 A;  4ZJS A;  2XZ6 A;  4QH5 A;  3U8N A;  3C79 A;  2WZY A;  2X00 D;  4HQP A;  4UM3 S;  4ZZB A;  4UM3 P;  5KZU A;  3SQ9 A;  2BYN A;  2PH9 A;  3SIO A;  5AFM B;  4LMK A;  2XQ3 A;  2XQ4 A;  4TNV A;  2XQ5 A;  3UUB A;  4LMJ A;  3UU8 A;  4HFC A;  1UW6 A;  3T4M A;  3U8J A;  4BFQ A;  2XNU A;  3WTH A;  2ZJU A;  2Y56 A;  3SQ6 A;  3UU3 A;  3JAF A;  4LML A;  3TLW A; 
#chains in the Genus database with same CATH homology
 3PMZ A;  4XHE A;  4HFE A;  2YKS A;  4NPP A;  3WTO A;  5AFN A;  5L47 A;  3ZKR A;  4ZK4 A;  3U8M A;  5J5I A;  2ZJV A;  2XQA A;  2XYS A;  2YOE A;  3RI5 A;  5L4H A;  3TLV A;  5L4E A;  5AFL A;  4UY2 A;  2BYS A;  3JAE A;  4DBM A;  2BG9 B;  4HFD A;  3GUA A;  5HEU A;  4ZK1 A;  4IL9 A;  4Z90 A;  5BW2 A;  2BYP A;  2YN6 A;  2BYQ A;  4HFH A;  5J5F A;  2X00 A;  5TVC A;  3U8K A;  4QAC A;  2Y57 A;  2C9T A;  2WNL A;  4TWD A;  2XQ7 A;  1I9B A;  2BYR A;  2YME A;  2XQ6 A;  3U8L A;  3UU4 A;  3IGQ A;  3RHW A;  4A98 A;  3RQU A;  4QH1 A;  5IUX A;  4ALX A;  4Z91 A;  2BG9 C;  4ILB A;  3WIP A;  2Y54 A;  2YMD A;  5CO5 A;  2XNT A;  4ILC A;  5AFK A;  4UM3 A;  4PIR A;  4HFI A;  3RIA A;  3UU5 A;  4ZZC A;  4XK9 A;  4ZR6 A;  5SYO A;  2W8G A;  5HEJ A;  2PGZ A;  4UXU A;  5J5G A;  5J5H A;  3TLS A;  4UM1 A;  3WTM A;  5BP0 A;  3EAM A;  5HCM A;  2BR8 A;  5LXB A;  4NZB A;  2XQ8 A;  3ZDG A;  4B5D A;  2XQ9 A;  3P50 A;  3PEO A;  4F8H A;  4COF A;  4AFH A;  3RIF A;  5LG3 A;  2Y58 A;  3WTL A;  3UQ7 A;  4HFB A;  3SH1 A;  2QC1 B;  1UX2 A;  3P4W A;  4ZRU A;  4A97 A;  5AFH A;  3LSV A;  5FJV A;  4ZJT A;  3JAD A;  5AFJ A;  3UU6 A;  5J0Z A;  2BG9 A;  3WTN A;  5AFM A;  2XZ5 A;  5HEG A;  3TLU A;  4BQT A;  3EI0 A;  3RQW A;  3ZDH A;  3TLT A;  2BR7 A;  4FRR A;  3WTJ A;  3WTK A;  2BJ0 A;  4AFT A;  2W8F A;  5HEO A;  4TWH A;  4AFG A;  2BG9 E;  5AIN A;  3WTI A;  5HEH A;  4QAA A;  5JME A;  4ILA A;  5BRX A;  2WN9 A;  4D01 A;  5CFB A;  4IRE A;  2UZ6 A;  2VL0 A;  2WNC A;  4QAB A;  4WV9 A;  2WNJ A;  4TWF A;  2XYT A;  5HCJ A;  3UQ4 A;  4EZ1 A;  5KE4 A;  4X5T A;  4IL4 A;  4QH4 A;  1UV6 A;  4TNW A;  2XNV A;  3EHZ A;  2Y7Y A;  3C84 A;  4ZJS A;  2XZ6 A;  4QH5 A;  3U8N A;  3C79 A;  2WZY A;  2X00 D;  4HQP A;  4UM3 S;  4ZZB A;  4UM3 P;  5KZU A;  3SQ9 A;  2BYN A;  2PH9 A;  3SIO A;  5AFM B;  4LMK A;  2XQ3 A;  2XQ4 A;  4TNV A;  2XQ5 A;  3UUB A;  4LMJ A;  3UU8 A;  4HFC A;  1UW6 A;  3T4M A;  3U8J A;  4BFQ A;  2XNU A;  3WTH A;  2ZJU A;  2Y56 A;  3SQ6 A;  3UU3 A;  3JAF A;  4LML A;  3TLW A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...