3U8MA

Crystal structure of the acetylcholine binding protein (achbp) from lymnaea stagnalis in complex with ns3920 (1-(6-bromopyridin-3-yl)-1,4-diazepane)
Total Genus 49
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
49
sequence length
206
structure length
202
Chain Sequence
LDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLARVVSDGEVLYMPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTDDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKGR
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Intersubunit bridge formation governs agonist efficacy at nicotinic acetylcholine alpha 4 beta 2 receptors: unique role of halogen bonding revealed.
pubmed doi rcsb
molecule tags Acetylcholine-binding protein/agonist
source organism Lymnaea stagnalis
molecule keywords Acetylcholine-binding protein
total genus 49
structure length 202
sequence length 206
chains with identical sequence B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T
ec nomenclature
pdb deposition date 2011-10-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02931 Neur_chan_LBD Neurotransmitter-gated ion-channel ligand binding domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.170.10 Mainly Beta Distorted Sandwich Acetylcholine Binding Protein; Chain: A, Neurotransmitter-gated ion-channel ligand-binding domain 3u8mA00
2BG9A 5TVCA 5BW2A 3UQ4A 3TLVA 4AFTA 5L47A 4TNWA 2X00A 4XK9A 3UQ7A 4D01A 4ZJSA 2C9TA 2X00D 3EI0A 3WTHA 5LG3A 4HQPA 4LMJA 4TNVA 5HEGA 2BYSA 4A98A 3LSVA 4NZBA 4TWHA 2Y58A 4IREA 3C79A 4ZJTA 3WTIA 4B5DA 3ZDHA 4COFA 2XZ6A 3UU6A 2XNUA 4TWDA 3T4MA 5AFMB 2WNJA 5CO5A 3TLSA 3C84A 4A97A 4QACA 4TWFA 3WTOA 3UUBA 2XYSA 2XQ8A 4ZR6A 5IUXA 3JADA 3U8LA 4DBMA 4UM3A 4UY2A 4ALXA 5J5FA 5AFNA 2XQ9A 3WTMA 3GUAA 3WTNA 4UM3P 2XNVA 2W8GA 2XQ7A 3WTLA 3WTKA 2BYPA 5BP0A 3WIPA 4QH5A 3WTJA 4FRRA 4Z91A 5HEJA 3U8MA 4HFBA 3TLTA 3U8KA 4BFQA 5HEHA 5L4HA 5HEUA 3UU3A 3PEOA 4PIRA 5JMEA 2BR8A 2QC1B 1UX2A 2Y56A 3RQUA 2ZJVA 2YOEA 2XQ5A 4EZ1A 4X5TA 5J5GA 3ZKRA 4HFEA 4HFCA 4ILAA 2BYQA 5CFBA 2YKSA 5LXBA 3TLUA 5SYOA 2BG9C 5FJVA 3RQWA 3UU5A 1UV6A 2VL0A 3RIFA 3SIOA 4IL9A 5L4EA 3JAFA 5AFHA 2XQ6A 2Y54A 4UM3S 4ZZBA 4HFIA 4QH4A 3JAEA 4XHEA 2BR7A 3RHWA 3SQ9A 3UU8A 3U8JA 2XQ3A 4UM1A 5J0ZA 4ZK4A 3ZDGA 5AFMA 5KE4A 2XYTA 2BG9E 4QABA 3TLWA 3U8NA 5J5HA 5HCMA 1UW6A 2Y7YA 4QH1A 2BYNA 3P50A 4LMLA 4NPPA 2W8FA 4IL4A 3RI5A 2XZ5A 3IGQA 4QAAA 5AFLA 3PMZA 2UZ6A 4ILBA 2PH9A 2WNCA 2YMDA 4HFDA 2BG9B 3SH1A 3RIAA 3UU4A 2WZYA 4ILCA 4UXUA 2PGZA 5AINA 2XQAA 4AFHA 5HCJA 4ZK1A 4HFHA 4LMKA 3EHZA 4ZRUA 5BRXA 2BJ0A 3EAMA 4WV9A 4ZZCA 2WN9A 4BQTA 2Y57A 5KZUA 4Z90A 2YMEA 4AFGA 2BYRA 1I9BA 4F8HA 2XQ4A 2WNLA 5AFJA 5HEOA 5AFKA 3SQ6A 5J5IA 2YN6A 3P4WA 2XNTA 2ZJUA
chains in the Genus database with same CATH superfamily
2BG9A 5TVCA 5BW2A 3UQ4A 3TLVA 4AFTA 5L47A 4TNWA 2X00A 4XK9A 3UQ7A 4D01A 4ZJSA 2C9TA 2X00D 3EI0A 3WTHA 5LG3A 4HQPA 4LMJA 4TNVA 5HEGA 2BYSA 4A98A 3LSVA 4NZBA 4TWHA 2Y58A 4IREA 3C79A 4ZJTA 3WTIA 4B5DA 3ZDHA 4COFA 2XZ6A 3UU6A 2XNUA 4TWDA 3T4MA 5AFMB 2WNJA 5CO5A 3TLSA 3C84A 4A97A 4QACA 4TWFA 3WTOA 3UUBA 2XYSA 2XQ8A 4ZR6A 5IUXA 3JADA 3U8LA 4DBMA 4UM3A 4UY2A 4ALXA 5J5FA 5AFNA 2XQ9A 3WTMA 3GUAA 3WTNA 4UM3P 2XNVA 2W8GA 2XQ7A 3WTLA 3WTKA 2BYPA 5BP0A 3WIPA 4QH5A 3WTJA 4FRRA 4Z91A 5HEJA 3U8MA 4HFBA 3TLTA 3U8KA 4BFQA 5HEHA 5L4HA 5HEUA 3UU3A 3PEOA 4PIRA 5JMEA 2BR8A 2QC1B 1UX2A 2Y56A 3RQUA 2ZJVA 2YOEA 2XQ5A 4EZ1A 4X5TA 5J5GA 3ZKRA 4HFEA 4HFCA 4ILAA 2BYQA 5CFBA 2YKSA 5LXBA 3TLUA 5SYOA 2BG9C 5FJVA 3RQWA 3UU5A 1UV6A 2VL0A 3RIFA 3SIOA 4IL9A 5L4EA 3JAFA 5AFHA 2XQ6A 2Y54A 4UM3S 4ZZBA 4HFIA 4QH4A 3JAEA 4XHEA 2BR7A 3RHWA 3SQ9A 3UU8A 3U8JA 2XQ3A 4UM1A 5J0ZA 4ZK4A 3ZDGA 5AFMA 5KE4A 2XYTA 2BG9E 4QABA 3TLWA 3U8NA 5J5HA 5HCMA 1UW6A 2Y7YA 4QH1A 2BYNA 3P50A 4LMLA 4NPPA 2W8FA 4IL4A 3RI5A 2XZ5A 3IGQA 4QAAA 5AFLA 3PMZA 2UZ6A 4ILBA 2PH9A 2WNCA 2YMDA 4HFDA 2BG9B 3SH1A 3RIAA 3UU4A 2WZYA 4ILCA 4UXUA 2PGZA 5AINA 2XQAA 4AFHA 5HCJA 4ZK1A 4HFHA 4LMKA 3EHZA 4ZRUA 5BRXA 2BJ0A 3EAMA 4WV9A 4ZZCA 2WN9A 4BQTA 2Y57A 5KZUA 4Z90A 2YMEA 4AFGA 2BYRA 1I9BA 4F8HA 2XQ4A 2WNLA 5AFJA 5HEOA 5AFKA 3SQ6A 5J5IA 2YN6A 3P4WA 2XNTA 2ZJUA
chains in the Genus database with same CATH topology
2BG9A 5TVCA 5BW2A 3UQ4A 3TLVA 4AFTA 5L47A 4TNWA 2X00A 4XK9A 3UQ7A 4D01A 4ZJSA 2C9TA 2X00D 3EI0A 3WTHA 5LG3A 4HQPA 4LMJA 4TNVA 5HEGA 2BYSA 4A98A 3LSVA 4NZBA 4TWHA 2Y58A 4IREA 3C79A 4ZJTA 3WTIA 4B5DA 3ZDHA 4COFA 2XZ6A 3UU6A 2XNUA 4TWDA 3T4MA 5AFMB 2WNJA 5CO5A 3TLSA 3C84A 4A97A 4QACA 4TWFA 3WTOA 3UUBA 2XYSA 2XQ8A 4ZR6A 5IUXA 3JADA 3U8LA 4DBMA 4UM3A 4UY2A 4ALXA 5J5FA 5AFNA 2XQ9A 3WTMA 3GUAA 3WTNA 4UM3P 2XNVA 2W8GA 2XQ7A 3WTLA 3WTKA 2BYPA 5BP0A 3WIPA 4QH5A 3WTJA 4FRRA 4Z91A 5HEJA 3U8MA 4HFBA 3TLTA 3U8KA 4BFQA 5HEHA 5L4HA 5HEUA 3UU3A 3PEOA 4PIRA 5JMEA 2BR8A 2QC1B 1UX2A 2Y56A 3RQUA 2ZJVA 2YOEA 2XQ5A 4EZ1A 4X5TA 5J5GA 3ZKRA 4HFEA 4HFCA 4ILAA 2BYQA 5CFBA 2YKSA 5LXBA 3TLUA 5SYOA 2BG9C 5FJVA 3RQWA 3UU5A 1UV6A 2VL0A 3RIFA 3SIOA 4IL9A 5L4EA 3JAFA 5AFHA 2XQ6A 2Y54A 4UM3S 4ZZBA 4HFIA 4QH4A 3JAEA 4XHEA 2BR7A 3RHWA 3SQ9A 3UU8A 3U8JA 2XQ3A 4UM1A 5J0ZA 4ZK4A 3ZDGA 5AFMA 5KE4A 2XYTA 2BG9E 4QABA 3TLWA 3U8NA 5J5HA 5HCMA 1UW6A 2Y7YA 4QH1A 2BYNA 3P50A 4LMLA 4NPPA 2W8FA 4IL4A 3RI5A 2XZ5A 3IGQA 4QAAA 5AFLA 3PMZA 2UZ6A 4ILBA 2PH9A 2WNCA 2YMDA 4HFDA 2BG9B 3SH1A 3RIAA 3UU4A 2WZYA 4ILCA 4UXUA 2PGZA 5AINA 2XQAA 4AFHA 5HCJA 4ZK1A 4HFHA 4LMKA 3EHZA 4ZRUA 5BRXA 2BJ0A 3EAMA 4WV9A 4ZZCA 2WN9A 4BQTA 2Y57A 5KZUA 4Z90A 2YMEA 4AFGA 2BYRA 1I9BA 4F8HA 2XQ4A 2WNLA 5AFJA 5HEOA 5AFKA 3SQ6A 5J5IA 2YN6A 3P4WA 2XNTA 2ZJUA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2BG9 A;  5TVC A;  5BW2 A;  3UQ4 A;  3TLV A;  4AFT A;  5L47 A;  4TNW A;  2X00 A;  4XK9 A;  3UQ7 A;  4D01 A;  4ZJS A;  2C9T A;  2X00 D;  3EI0 A;  3WTH A;  5LG3 A;  4HQP A;  4LMJ A;  4TNV A;  5HEG A;  2BYS A;  4A98 A;  3LSV A;  4NZB A;  4TWH A;  2Y58 A;  4IRE A;  3C79 A;  4ZJT A;  3WTI A;  4B5D A;  3ZDH A;  4COF A;  2XZ6 A;  3UU6 A;  2XNU A;  4TWD A;  3T4M A;  5AFM B;  2WNJ A;  5CO5 A;  3TLS A;  3C84 A;  4A97 A;  4QAC A;  4TWF A;  3WTO A;  3UUB A;  2XYS A;  2XQ8 A;  4ZR6 A;  5IUX A;  3JAD A;  3U8L A;  4DBM A;  4UM3 A;  4UY2 A;  4ALX A;  5J5F A;  5AFN A;  2XQ9 A;  3WTM A;  3GUA A;  3WTN A;  4UM3 P;  2XNV A;  2W8G A;  2XQ7 A;  3WTL A;  3WTK A;  2BYP A;  5BP0 A;  3WIP A;  4QH5 A;  3WTJ A;  4FRR A;  4Z91 A;  5HEJ A;  3U8M A;  4HFB A;  3TLT A;  3U8K A;  4BFQ A;  5HEH A;  5L4H A;  5HEU A;  3UU3 A;  3PEO A;  4PIR A;  5JME A;  2BR8 A;  2QC1 B;  1UX2 A;  2Y56 A;  3RQU A;  2ZJV A;  2YOE A;  2XQ5 A;  4EZ1 A;  4X5T A;  5J5G A;  3ZKR A;  4HFE A;  4HFC A;  4ILA A;  2BYQ A;  5CFB A;  2YKS A;  5LXB A;  3TLU A;  5SYO A;  2BG9 C;  5FJV A;  3RQW A;  3UU5 A;  1UV6 A;  2VL0 A;  3RIF A;  3SIO A;  4IL9 A;  5L4E A;  3JAF A;  5AFH A;  2XQ6 A;  2Y54 A;  4UM3 S;  4ZZB A;  4HFI A;  4QH4 A;  3JAE A;  4XHE A;  2BR7 A;  3RHW A;  3SQ9 A;  3UU8 A;  3U8J A;  2XQ3 A;  4UM1 A;  5J0Z A;  4ZK4 A;  3ZDG A;  5AFM A;  5KE4 A;  2XYT A;  2BG9 E;  4QAB A;  3TLW A;  3U8N A;  5J5H A;  5HCM A;  1UW6 A;  2Y7Y A;  4QH1 A;  2BYN A;  3P50 A;  4LML A;  4NPP A;  2W8F A;  4IL4 A;  3RI5 A;  2XZ5 A;  3IGQ A;  4QAA A;  5AFL A;  3PMZ A;  2UZ6 A;  4ILB A;  2PH9 A;  2WNC A;  2YMD A;  4HFD A;  2BG9 B;  3SH1 A;  3RIA A;  3UU4 A;  2WZY A;  4ILC A;  4UXU A;  2PGZ A;  5AIN A;  2XQA A;  4AFH A;  5HCJ A;  4ZK1 A;  4HFH A;  4LMK A;  3EHZ A;  4ZRU A;  5BRX A;  2BJ0 A;  3EAM A;  4WV9 A;  4ZZC A;  2WN9 A;  4BQT A;  2Y57 A;  5KZU A;  4Z90 A;  2YME A;  4AFG A;  2BYR A;  1I9B A;  4F8H A;  2XQ4 A;  2WNL A;  5AFJ A;  5HEO A;  5AFK A;  3SQ6 A;  5J5I A;  2YN6 A;  3P4W A;  2XNT A;  2ZJU A; 
#chains in the Genus database with same CATH topology
 2BG9 A;  5TVC A;  5BW2 A;  3UQ4 A;  3TLV A;  4AFT A;  5L47 A;  4TNW A;  2X00 A;  4XK9 A;  3UQ7 A;  4D01 A;  4ZJS A;  2C9T A;  2X00 D;  3EI0 A;  3WTH A;  5LG3 A;  4HQP A;  4LMJ A;  4TNV A;  5HEG A;  2BYS A;  4A98 A;  3LSV A;  4NZB A;  4TWH A;  2Y58 A;  4IRE A;  3C79 A;  4ZJT A;  3WTI A;  4B5D A;  3ZDH A;  4COF A;  2XZ6 A;  3UU6 A;  2XNU A;  4TWD A;  3T4M A;  5AFM B;  2WNJ A;  5CO5 A;  3TLS A;  3C84 A;  4A97 A;  4QAC A;  4TWF A;  3WTO A;  3UUB A;  2XYS A;  2XQ8 A;  4ZR6 A;  5IUX A;  3JAD A;  3U8L A;  4DBM A;  4UM3 A;  4UY2 A;  4ALX A;  5J5F A;  5AFN A;  2XQ9 A;  3WTM A;  3GUA A;  3WTN A;  4UM3 P;  2XNV A;  2W8G A;  2XQ7 A;  3WTL A;  3WTK A;  2BYP A;  5BP0 A;  3WIP A;  4QH5 A;  3WTJ A;  4FRR A;  4Z91 A;  5HEJ A;  3U8M A;  4HFB A;  3TLT A;  3U8K A;  4BFQ A;  5HEH A;  5L4H A;  5HEU A;  3UU3 A;  3PEO A;  4PIR A;  5JME A;  2BR8 A;  2QC1 B;  1UX2 A;  2Y56 A;  3RQU A;  2ZJV A;  2YOE A;  2XQ5 A;  4EZ1 A;  4X5T A;  5J5G A;  3ZKR A;  4HFE A;  4HFC A;  4ILA A;  2BYQ A;  5CFB A;  2YKS A;  5LXB A;  3TLU A;  5SYO A;  2BG9 C;  5FJV A;  3RQW A;  3UU5 A;  1UV6 A;  2VL0 A;  3RIF A;  3SIO A;  4IL9 A;  5L4E A;  3JAF A;  5AFH A;  2XQ6 A;  2Y54 A;  4UM3 S;  4ZZB A;  4HFI A;  4QH4 A;  3JAE A;  4XHE A;  2BR7 A;  3RHW A;  3SQ9 A;  3UU8 A;  3U8J A;  2XQ3 A;  4UM1 A;  5J0Z A;  4ZK4 A;  3ZDG A;  5AFM A;  5KE4 A;  2XYT A;  2BG9 E;  4QAB A;  3TLW A;  3U8N A;  5J5H A;  5HCM A;  1UW6 A;  2Y7Y A;  4QH1 A;  2BYN A;  3P50 A;  4LML A;  4NPP A;  2W8F A;  4IL4 A;  3RI5 A;  2XZ5 A;  3IGQ A;  4QAA A;  5AFL A;  3PMZ A;  2UZ6 A;  4ILB A;  2PH9 A;  2WNC A;  2YMD A;  4HFD A;  2BG9 B;  3SH1 A;  3RIA A;  3UU4 A;  2WZY A;  4ILC A;  4UXU A;  2PGZ A;  5AIN A;  2XQA A;  4AFH A;  5HCJ A;  4ZK1 A;  4HFH A;  4LMK A;  3EHZ A;  4ZRU A;  5BRX A;  2BJ0 A;  3EAM A;  4WV9 A;  4ZZC A;  2WN9 A;  4BQT A;  2Y57 A;  5KZU A;  4Z90 A;  2YME A;  4AFG A;  2BYR A;  1I9B A;  4F8H A;  2XQ4 A;  2WNL A;  5AFJ A;  5HEO A;  5AFK A;  3SQ6 A;  5J5I A;  2YN6 A;  3P4W A;  2XNT A;  2ZJU A; 
#chains in the Genus database with same CATH homology
 2BG9 A;  5TVC A;  5BW2 A;  3UQ4 A;  3TLV A;  4AFT A;  5L47 A;  4TNW A;  2X00 A;  4XK9 A;  3UQ7 A;  4D01 A;  4ZJS A;  2C9T A;  2X00 D;  3EI0 A;  3WTH A;  5LG3 A;  4HQP A;  4LMJ A;  4TNV A;  5HEG A;  2BYS A;  4A98 A;  3LSV A;  4NZB A;  4TWH A;  2Y58 A;  4IRE A;  3C79 A;  4ZJT A;  3WTI A;  4B5D A;  3ZDH A;  4COF A;  2XZ6 A;  3UU6 A;  2XNU A;  4TWD A;  3T4M A;  5AFM B;  2WNJ A;  5CO5 A;  3TLS A;  3C84 A;  4A97 A;  4QAC A;  4TWF A;  3WTO A;  3UUB A;  2XYS A;  2XQ8 A;  4ZR6 A;  5IUX A;  3JAD A;  3U8L A;  4DBM A;  4UM3 A;  4UY2 A;  4ALX A;  5J5F A;  5AFN A;  2XQ9 A;  3WTM A;  3GUA A;  3WTN A;  4UM3 P;  2XNV A;  2W8G A;  2XQ7 A;  3WTL A;  3WTK A;  2BYP A;  5BP0 A;  3WIP A;  4QH5 A;  3WTJ A;  4FRR A;  4Z91 A;  5HEJ A;  3U8M A;  4HFB A;  3TLT A;  3U8K A;  4BFQ A;  5HEH A;  5L4H A;  5HEU A;  3UU3 A;  3PEO A;  4PIR A;  5JME A;  2BR8 A;  2QC1 B;  1UX2 A;  2Y56 A;  3RQU A;  2ZJV A;  2YOE A;  2XQ5 A;  4EZ1 A;  4X5T A;  5J5G A;  3ZKR A;  4HFE A;  4HFC A;  4ILA A;  2BYQ A;  5CFB A;  2YKS A;  5LXB A;  3TLU A;  5SYO A;  2BG9 C;  5FJV A;  3RQW A;  3UU5 A;  1UV6 A;  2VL0 A;  3RIF A;  3SIO A;  4IL9 A;  5L4E A;  3JAF A;  5AFH A;  2XQ6 A;  2Y54 A;  4UM3 S;  4ZZB A;  4HFI A;  4QH4 A;  3JAE A;  4XHE A;  2BR7 A;  3RHW A;  3SQ9 A;  3UU8 A;  3U8J A;  2XQ3 A;  4UM1 A;  5J0Z A;  4ZK4 A;  3ZDG A;  5AFM A;  5KE4 A;  2XYT A;  2BG9 E;  4QAB A;  3TLW A;  3U8N A;  5J5H A;  5HCM A;  1UW6 A;  2Y7Y A;  4QH1 A;  2BYN A;  3P50 A;  4LML A;  4NPP A;  2W8F A;  4IL4 A;  3RI5 A;  2XZ5 A;  3IGQ A;  4QAA A;  5AFL A;  3PMZ A;  2UZ6 A;  4ILB A;  2PH9 A;  2WNC A;  2YMD A;  4HFD A;  2BG9 B;  3SH1 A;  3RIA A;  3UU4 A;  2WZY A;  4ILC A;  4UXU A;  2PGZ A;  5AIN A;  2XQA A;  4AFH A;  5HCJ A;  4ZK1 A;  4HFH A;  4LMK A;  3EHZ A;  4ZRU A;  5BRX A;  2BJ0 A;  3EAM A;  4WV9 A;  4ZZC A;  2WN9 A;  4BQT A;  2Y57 A;  5KZU A;  4Z90 A;  2YME A;  4AFG A;  2BYR A;  1I9B A;  4F8H A;  2XQ4 A;  2WNL A;  5AFJ A;  5HEO A;  5AFK A;  3SQ6 A;  5J5I A;  2YN6 A;  3P4W A;  2XNT A;  2ZJU A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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