5TVCA

Crystal structure of a chimeric acetylcholine binding protein from aplysia californica (ac-achbp) containing loop c from the human alpha 3 nicotinic acetylcholine receptor in complex with (e,2s)-n-methyl-5-(5-phenoxy-3-pyridyl)pent-4-en-2-amine (ti-5312)
Total Genus 47
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
47
sequence length
216
structure length
211
Chain Sequence
DKLHSQANLMRLKSDLFYPGPTKDDPLTVTLGFTLQDIVKADSSTNEVDLVYWEQQRWKLNSLMWDPNEYGNITDFRTSAADIWTPDITAYSSTRPVQVLSPQIAVVTHDGSVMFIPAQRLSFMCDPTGVDSEEGATCAVKFGSWVYSGFEIDLKTDTDQVDLSSYYASSKYEILSATQYKHDIKYNCCEEIYPDVVLVVKFRERRAGNGF
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Acetylcholine-binding protein
molecule keywords Soluble acetylcholine receptor,Neuronal acetylcholine recept
publication title Crystal structure of a chimeric acetylcholine binding protein from Aplysia californica (Ac-AChBP) containing loop C from the human alpha 3 nicotinic acetylcholine receptor in complex with (E,2S)-N-methyl-5-(5-phenoxy-3-pyridyl)pent-4-en-2-amine (TI-5312)
rcsb
source organism Aplysia californica
total genus 47
structure length 211
sequence length 216
chains with identical sequence B, C, D, E
ec nomenclature
pdb deposition date 2016-11-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02931 Neur_chan_LBD Neurotransmitter-gated ion-channel ligand binding domain
A PF02931 Neur_chan_LBD Neurotransmitter-gated ion-channel ligand binding domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.170.10 Mainly Beta Distorted Sandwich Acetylcholine Binding Protein; Chain: A, Neurotransmitter-gated ion-channel ligand-binding domain 5tvcA00
4HFBA 3GUAA 4WV9A 4TNVA 4EZ1A 3ZDGA 2YMDA 3RIFA 2BG9E 2BR8A 2W8FA 5J0ZA 4LMKA 2PGZA 3WTJA 3UUBA 5AINA 4HFEA 5HEGA 4ZRUA 3JAEA 2WN9A 3P50A 3P4WA 3TLUA 4AFTA 2W8GA 5AFJA 3RQWA 5KZUA 5LG3A 4ILBA 3U8NA 2XYTA 4AFGA 3ZKRA 3WTMA 3TLWA 4UM1A 5HEUA 3WTLA 4BQTA 3TLSA 5AFLA 5AFNA 4ILAA 4QABA 5L4HA 2YOEA 1UX2A 4A97A 3UU6A 3U8LA 1UW6A 3UQ4A 3LSVA 2XNVA 2XQ9A 4COFA 2X00D 5J5FA 4QACA 2XQ3A 4TWDA 5KE4A 5L4EA 3EHZA 3C84A 4PIRA 4X5TA 3U8KA 3WTOA 5BRXA 3IGQA 4QH1A 3JADA 3UU8A 5CO5A 5FJVA 3UU4A 2BYPA 5TVCA 4QH5A 4A98A 2Y56A 5HEOA 4NZBA 5J5GA 2BYSA 4ZZCA 4D01A 5SYOA 2XNTA 5L47A 2Y7YA 2ZJVA 4LMJA 3EAMA 5HCJA 5IUXA 4XHEA 5J5IA 2XQ7A 2XZ6A 2WNCA 4TWFA 2BYNA 2WNJA 3EI0A 4AFHA 2BG9A 3UQ7A 2BR7A 4IL4A 2BG9C 3ZDHA 5AFKA 3SQ6A 5HCMA 4NPPA 3U8MA 2WNLA 5AFHA 4ZJTA 1UV6A 2PH9A 4Z91A 2XYSA 2Y58A 2QC1B 4ZJSA 3RQUA 2Y54A 4B5DA 4IL9A 2YN6A 3T4MA 2UZ6A 2BJ0A 3SH1A 3PEOA 2BYRA 4ZK1A 4ALXA 4BFQA 3PMZA 3SQ9A 2WZYA 4UY2A 4HFDA 3UU3A 5LXBA 3TLVA 2X00A 2XQ8A 4ZZBA 3C79A 4ILCA 4DBMA 3WTHA 4UM3S 4HFIA 1I9BA 3SIOA 5AFMA 2XNUA 4UXUA 2XQ4A 2YKSA 5HEHA 3WTNA 3UU5A 2YMEA 2XQAA 4UM3A 4TWHA 4QAAA 3TLTA 2BYQA 4LMLA 2XQ5A 4ZK4A 4ZR6A 4HFHA 4XK9A 5AFMB 2C9TA 4HFCA 3RHWA 2XQ6A 5BP0A 3WTKA 5CFBA 2Y57A 4QH4A 2BG9B 3RIAA 4FRRA 5JMEA 2XZ5A 5HEJA 2VL0A 3WIPA 5J5HA 3U8JA 4HQPA 3JAFA 4UM3P 3RI5A 4IREA 5BW2A 2ZJUA 4Z90A 3WTIA 4TNWA 4F8HA
chains in the Genus database with same CATH superfamily
4HFBA 3GUAA 4WV9A 4TNVA 4EZ1A 3ZDGA 2YMDA 3RIFA 2BG9E 2BR8A 2W8FA 5J0ZA 4LMKA 2PGZA 3WTJA 3UUBA 5AINA 4HFEA 5HEGA 4ZRUA 3JAEA 2WN9A 3P50A 3P4WA 3TLUA 4AFTA 2W8GA 5AFJA 3RQWA 5KZUA 5LG3A 4ILBA 3U8NA 2XYTA 4AFGA 3ZKRA 3WTMA 3TLWA 4UM1A 5HEUA 3WTLA 4BQTA 3TLSA 5AFLA 5AFNA 4ILAA 4QABA 5L4HA 2YOEA 1UX2A 4A97A 3UU6A 3U8LA 1UW6A 3UQ4A 3LSVA 2XNVA 2XQ9A 4COFA 2X00D 5J5FA 4QACA 2XQ3A 4TWDA 5KE4A 5L4EA 3EHZA 3C84A 4PIRA 4X5TA 3U8KA 3WTOA 5BRXA 3IGQA 4QH1A 3JADA 3UU8A 5CO5A 5FJVA 3UU4A 2BYPA 5TVCA 4QH5A 4A98A 2Y56A 5HEOA 4NZBA 5J5GA 2BYSA 4ZZCA 4D01A 5SYOA 2XNTA 5L47A 2Y7YA 2ZJVA 4LMJA 3EAMA 5HCJA 5IUXA 4XHEA 5J5IA 2XQ7A 2XZ6A 2WNCA 4TWFA 2BYNA 2WNJA 3EI0A 4AFHA 2BG9A 3UQ7A 2BR7A 4IL4A 2BG9C 3ZDHA 5AFKA 3SQ6A 5HCMA 4NPPA 3U8MA 2WNLA 5AFHA 4ZJTA 1UV6A 2PH9A 4Z91A 2XYSA 2Y58A 2QC1B 4ZJSA 3RQUA 2Y54A 4B5DA 4IL9A 2YN6A 3T4MA 2UZ6A 2BJ0A 3SH1A 3PEOA 2BYRA 4ZK1A 4ALXA 4BFQA 3PMZA 3SQ9A 2WZYA 4UY2A 4HFDA 3UU3A 5LXBA 3TLVA 2X00A 2XQ8A 4ZZBA 3C79A 4ILCA 4DBMA 3WTHA 4UM3S 4HFIA 1I9BA 3SIOA 5AFMA 2XNUA 4UXUA 2XQ4A 2YKSA 5HEHA 3WTNA 3UU5A 2YMEA 2XQAA 4UM3A 4TWHA 4QAAA 3TLTA 2BYQA 4LMLA 2XQ5A 4ZK4A 4ZR6A 4HFHA 4XK9A 5AFMB 2C9TA 4HFCA 3RHWA 2XQ6A 5BP0A 3WTKA 5CFBA 2Y57A 4QH4A 2BG9B 3RIAA 4FRRA 5JMEA 2XZ5A 5HEJA 2VL0A 3WIPA 5J5HA 3U8JA 4HQPA 3JAFA 4UM3P 3RI5A 4IREA 5BW2A 2ZJUA 4Z90A 3WTIA 4TNWA 4F8HA
chains in the Genus database with same CATH topology
4HFBA 3GUAA 4WV9A 4TNVA 4EZ1A 3ZDGA 2YMDA 3RIFA 2BG9E 2BR8A 2W8FA 5J0ZA 4LMKA 2PGZA 3WTJA 3UUBA 5AINA 4HFEA 5HEGA 4ZRUA 3JAEA 2WN9A 3P50A 3P4WA 3TLUA 4AFTA 2W8GA 5AFJA 3RQWA 5KZUA 5LG3A 4ILBA 3U8NA 2XYTA 4AFGA 3ZKRA 3WTMA 3TLWA 4UM1A 5HEUA 3WTLA 4BQTA 3TLSA 5AFLA 5AFNA 4ILAA 4QABA 5L4HA 2YOEA 1UX2A 4A97A 3UU6A 3U8LA 1UW6A 3UQ4A 3LSVA 2XNVA 2XQ9A 4COFA 2X00D 5J5FA 4QACA 2XQ3A 4TWDA 5KE4A 5L4EA 3EHZA 3C84A 4PIRA 4X5TA 3U8KA 3WTOA 5BRXA 3IGQA 4QH1A 3JADA 3UU8A 5CO5A 5FJVA 3UU4A 2BYPA 5TVCA 4QH5A 4A98A 2Y56A 5HEOA 4NZBA 5J5GA 2BYSA 4ZZCA 4D01A 5SYOA 2XNTA 5L47A 2Y7YA 2ZJVA 4LMJA 3EAMA 5HCJA 5IUXA 4XHEA 5J5IA 2XQ7A 2XZ6A 2WNCA 4TWFA 2BYNA 2WNJA 3EI0A 4AFHA 2BG9A 3UQ7A 2BR7A 4IL4A 2BG9C 3ZDHA 5AFKA 3SQ6A 5HCMA 4NPPA 3U8MA 2WNLA 5AFHA 4ZJTA 1UV6A 2PH9A 4Z91A 2XYSA 2Y58A 2QC1B 4ZJSA 3RQUA 2Y54A 4B5DA 4IL9A 2YN6A 3T4MA 2UZ6A 2BJ0A 3SH1A 3PEOA 2BYRA 4ZK1A 4ALXA 4BFQA 3PMZA 3SQ9A 2WZYA 4UY2A 4HFDA 3UU3A 5LXBA 3TLVA 2X00A 2XQ8A 4ZZBA 3C79A 4ILCA 4DBMA 3WTHA 4UM3S 4HFIA 1I9BA 3SIOA 5AFMA 2XNUA 4UXUA 2XQ4A 2YKSA 5HEHA 3WTNA 3UU5A 2YMEA 2XQAA 4UM3A 4TWHA 4QAAA 3TLTA 2BYQA 4LMLA 2XQ5A 4ZK4A 4ZR6A 4HFHA 4XK9A 5AFMB 2C9TA 4HFCA 3RHWA 2XQ6A 5BP0A 3WTKA 5CFBA 2Y57A 4QH4A 2BG9B 3RIAA 4FRRA 5JMEA 2XZ5A 5HEJA 2VL0A 3WIPA 5J5HA 3U8JA 4HQPA 3JAFA 4UM3P 3RI5A 4IREA 5BW2A 2ZJUA 4Z90A 3WTIA 4TNWA 4F8HA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4HFB A;  3GUA A;  4WV9 A;  4TNV A;  4EZ1 A;  3ZDG A;  2YMD A;  3RIF A;  2BG9 E;  2BR8 A;  2W8F A;  5J0Z A;  4LMK A;  2PGZ A;  3WTJ A;  3UUB A;  5AIN A;  4HFE A;  5HEG A;  4ZRU A;  3JAE A;  2WN9 A;  3P50 A;  3P4W A;  3TLU A;  4AFT A;  2W8G A;  5AFJ A;  3RQW A;  5KZU A;  5LG3 A;  4ILB A;  3U8N A;  2XYT A;  4AFG A;  3ZKR A;  3WTM A;  3TLW A;  4UM1 A;  5HEU A;  3WTL A;  4BQT A;  3TLS A;  5AFL A;  5AFN A;  4ILA A;  4QAB A;  5L4H A;  2YOE A;  1UX2 A;  4A97 A;  3UU6 A;  3U8L A;  1UW6 A;  3UQ4 A;  3LSV A;  2XNV A;  2XQ9 A;  4COF A;  2X00 D;  5J5F A;  4QAC A;  2XQ3 A;  4TWD A;  5KE4 A;  5L4E A;  3EHZ A;  3C84 A;  4PIR A;  4X5T A;  3U8K A;  3WTO A;  5BRX A;  3IGQ A;  4QH1 A;  3JAD A;  3UU8 A;  5CO5 A;  5FJV A;  3UU4 A;  2BYP A;  5TVC A;  4QH5 A;  4A98 A;  2Y56 A;  5HEO A;  4NZB A;  5J5G A;  2BYS A;  4ZZC A;  4D01 A;  5SYO A;  2XNT A;  5L47 A;  2Y7Y A;  2ZJV A;  4LMJ A;  3EAM A;  5HCJ A;  5IUX A;  4XHE A;  5J5I A;  2XQ7 A;  2XZ6 A;  2WNC A;  4TWF A;  2BYN A;  2WNJ A;  3EI0 A;  4AFH A;  2BG9 A;  3UQ7 A;  2BR7 A;  4IL4 A;  2BG9 C;  3ZDH A;  5AFK A;  3SQ6 A;  5HCM A;  4NPP A;  3U8M A;  2WNL A;  5AFH A;  4ZJT A;  1UV6 A;  2PH9 A;  4Z91 A;  2XYS A;  2Y58 A;  2QC1 B;  4ZJS A;  3RQU A;  2Y54 A;  4B5D A;  4IL9 A;  2YN6 A;  3T4M A;  2UZ6 A;  2BJ0 A;  3SH1 A;  3PEO A;  2BYR A;  4ZK1 A;  4ALX A;  4BFQ A;  3PMZ A;  3SQ9 A;  2WZY A;  4UY2 A;  4HFD A;  3UU3 A;  5LXB A;  3TLV A;  2X00 A;  2XQ8 A;  4ZZB A;  3C79 A;  4ILC A;  4DBM A;  3WTH A;  4UM3 S;  4HFI A;  1I9B A;  3SIO A;  5AFM A;  2XNU A;  4UXU A;  2XQ4 A;  2YKS A;  5HEH A;  3WTN A;  3UU5 A;  2YME A;  2XQA A;  4UM3 A;  4TWH A;  4QAA A;  3TLT A;  2BYQ A;  4LML A;  2XQ5 A;  4ZK4 A;  4ZR6 A;  4HFH A;  4XK9 A;  5AFM B;  2C9T A;  4HFC A;  3RHW A;  2XQ6 A;  5BP0 A;  3WTK A;  5CFB A;  2Y57 A;  4QH4 A;  2BG9 B;  3RIA A;  4FRR A;  5JME A;  2XZ5 A;  5HEJ A;  2VL0 A;  3WIP A;  5J5H A;  3U8J A;  4HQP A;  3JAF A;  4UM3 P;  3RI5 A;  4IRE A;  5BW2 A;  2ZJU A;  4Z90 A;  3WTI A;  4TNW A;  4F8H A; 
#chains in the Genus database with same CATH topology
 4HFB A;  3GUA A;  4WV9 A;  4TNV A;  4EZ1 A;  3ZDG A;  2YMD A;  3RIF A;  2BG9 E;  2BR8 A;  2W8F A;  5J0Z A;  4LMK A;  2PGZ A;  3WTJ A;  3UUB A;  5AIN A;  4HFE A;  5HEG A;  4ZRU A;  3JAE A;  2WN9 A;  3P50 A;  3P4W A;  3TLU A;  4AFT A;  2W8G A;  5AFJ A;  3RQW A;  5KZU A;  5LG3 A;  4ILB A;  3U8N A;  2XYT A;  4AFG A;  3ZKR A;  3WTM A;  3TLW A;  4UM1 A;  5HEU A;  3WTL A;  4BQT A;  3TLS A;  5AFL A;  5AFN A;  4ILA A;  4QAB A;  5L4H A;  2YOE A;  1UX2 A;  4A97 A;  3UU6 A;  3U8L A;  1UW6 A;  3UQ4 A;  3LSV A;  2XNV A;  2XQ9 A;  4COF A;  2X00 D;  5J5F A;  4QAC A;  2XQ3 A;  4TWD A;  5KE4 A;  5L4E A;  3EHZ A;  3C84 A;  4PIR A;  4X5T A;  3U8K A;  3WTO A;  5BRX A;  3IGQ A;  4QH1 A;  3JAD A;  3UU8 A;  5CO5 A;  5FJV A;  3UU4 A;  2BYP A;  5TVC A;  4QH5 A;  4A98 A;  2Y56 A;  5HEO A;  4NZB A;  5J5G A;  2BYS A;  4ZZC A;  4D01 A;  5SYO A;  2XNT A;  5L47 A;  2Y7Y A;  2ZJV A;  4LMJ A;  3EAM A;  5HCJ A;  5IUX A;  4XHE A;  5J5I A;  2XQ7 A;  2XZ6 A;  2WNC A;  4TWF A;  2BYN A;  2WNJ A;  3EI0 A;  4AFH A;  2BG9 A;  3UQ7 A;  2BR7 A;  4IL4 A;  2BG9 C;  3ZDH A;  5AFK A;  3SQ6 A;  5HCM A;  4NPP A;  3U8M A;  2WNL A;  5AFH A;  4ZJT A;  1UV6 A;  2PH9 A;  4Z91 A;  2XYS A;  2Y58 A;  2QC1 B;  4ZJS A;  3RQU A;  2Y54 A;  4B5D A;  4IL9 A;  2YN6 A;  3T4M A;  2UZ6 A;  2BJ0 A;  3SH1 A;  3PEO A;  2BYR A;  4ZK1 A;  4ALX A;  4BFQ A;  3PMZ A;  3SQ9 A;  2WZY A;  4UY2 A;  4HFD A;  3UU3 A;  5LXB A;  3TLV A;  2X00 A;  2XQ8 A;  4ZZB A;  3C79 A;  4ILC A;  4DBM A;  3WTH A;  4UM3 S;  4HFI A;  1I9B A;  3SIO A;  5AFM A;  2XNU A;  4UXU A;  2XQ4 A;  2YKS A;  5HEH A;  3WTN A;  3UU5 A;  2YME A;  2XQA A;  4UM3 A;  4TWH A;  4QAA A;  3TLT A;  2BYQ A;  4LML A;  2XQ5 A;  4ZK4 A;  4ZR6 A;  4HFH A;  4XK9 A;  5AFM B;  2C9T A;  4HFC A;  3RHW A;  2XQ6 A;  5BP0 A;  3WTK A;  5CFB A;  2Y57 A;  4QH4 A;  2BG9 B;  3RIA A;  4FRR A;  5JME A;  2XZ5 A;  5HEJ A;  2VL0 A;  3WIP A;  5J5H A;  3U8J A;  4HQP A;  3JAF A;  4UM3 P;  3RI5 A;  4IRE A;  5BW2 A;  2ZJU A;  4Z90 A;  3WTI A;  4TNW A;  4F8H A; 
#chains in the Genus database with same CATH homology
 4HFB A;  3GUA A;  4WV9 A;  4TNV A;  4EZ1 A;  3ZDG A;  2YMD A;  3RIF A;  2BG9 E;  2BR8 A;  2W8F A;  5J0Z A;  4LMK A;  2PGZ A;  3WTJ A;  3UUB A;  5AIN A;  4HFE A;  5HEG A;  4ZRU A;  3JAE A;  2WN9 A;  3P50 A;  3P4W A;  3TLU A;  4AFT A;  2W8G A;  5AFJ A;  3RQW A;  5KZU A;  5LG3 A;  4ILB A;  3U8N A;  2XYT A;  4AFG A;  3ZKR A;  3WTM A;  3TLW A;  4UM1 A;  5HEU A;  3WTL A;  4BQT A;  3TLS A;  5AFL A;  5AFN A;  4ILA A;  4QAB A;  5L4H A;  2YOE A;  1UX2 A;  4A97 A;  3UU6 A;  3U8L A;  1UW6 A;  3UQ4 A;  3LSV A;  2XNV A;  2XQ9 A;  4COF A;  2X00 D;  5J5F A;  4QAC A;  2XQ3 A;  4TWD A;  5KE4 A;  5L4E A;  3EHZ A;  3C84 A;  4PIR A;  4X5T A;  3U8K A;  3WTO A;  5BRX A;  3IGQ A;  4QH1 A;  3JAD A;  3UU8 A;  5CO5 A;  5FJV A;  3UU4 A;  2BYP A;  5TVC A;  4QH5 A;  4A98 A;  2Y56 A;  5HEO A;  4NZB A;  5J5G A;  2BYS A;  4ZZC A;  4D01 A;  5SYO A;  2XNT A;  5L47 A;  2Y7Y A;  2ZJV A;  4LMJ A;  3EAM A;  5HCJ A;  5IUX A;  4XHE A;  5J5I A;  2XQ7 A;  2XZ6 A;  2WNC A;  4TWF A;  2BYN A;  2WNJ A;  3EI0 A;  4AFH A;  2BG9 A;  3UQ7 A;  2BR7 A;  4IL4 A;  2BG9 C;  3ZDH A;  5AFK A;  3SQ6 A;  5HCM A;  4NPP A;  3U8M A;  2WNL A;  5AFH A;  4ZJT A;  1UV6 A;  2PH9 A;  4Z91 A;  2XYS A;  2Y58 A;  2QC1 B;  4ZJS A;  3RQU A;  2Y54 A;  4B5D A;  4IL9 A;  2YN6 A;  3T4M A;  2UZ6 A;  2BJ0 A;  3SH1 A;  3PEO A;  2BYR A;  4ZK1 A;  4ALX A;  4BFQ A;  3PMZ A;  3SQ9 A;  2WZY A;  4UY2 A;  4HFD A;  3UU3 A;  5LXB A;  3TLV A;  2X00 A;  2XQ8 A;  4ZZB A;  3C79 A;  4ILC A;  4DBM A;  3WTH A;  4UM3 S;  4HFI A;  1I9B A;  3SIO A;  5AFM A;  2XNU A;  4UXU A;  2XQ4 A;  2YKS A;  5HEH A;  3WTN A;  3UU5 A;  2YME A;  2XQA A;  4UM3 A;  4TWH A;  4QAA A;  3TLT A;  2BYQ A;  4LML A;  2XQ5 A;  4ZK4 A;  4ZR6 A;  4HFH A;  4XK9 A;  5AFM B;  2C9T A;  4HFC A;  3RHW A;  2XQ6 A;  5BP0 A;  3WTK A;  5CFB A;  2Y57 A;  4QH4 A;  2BG9 B;  3RIA A;  4FRR A;  5JME A;  2XZ5 A;  5HEJ A;  2VL0 A;  3WIP A;  5J5H A;  3U8J A;  4HQP A;  3JAF A;  4UM3 P;  3RI5 A;  4IRE A;  5BW2 A;  2ZJU A;  4Z90 A;  3WTI A;  4TNW A;  4F8H A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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