4QAAA

X-ray structure of acetylcholine binding protein (achbp) in complex with 6-(4-methoxyphenyl)-n4-octylpyrimidine-2,4-diamine
Total Genus 45
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
45
sequence length
213
structure length
207
Chain Sequence
DYKDDDDKLDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLARVVSDGEVLYMPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTTENSDDSEYFSQYSRFEILDVTQKKNSVEAYEDVEVSLNFRKKG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural basis for cooperative interactions of substituted 2-aminopyrimidines with the acetylcholine binding protein.
pubmed doi rcsb
molecule keywords Acetylcholine-binding protein
molecule tags Acetylcholine-binding protein
source organism Lymnaea stagnalis
total genus 45
structure length 207
sequence length 213
chains with identical sequence B, C, D, E, F, G, H, I, J
ec nomenclature
pdb deposition date 2014-05-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02931 Neur_chan_LBD Neurotransmitter-gated ion-channel ligand binding domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.170.10 Mainly Beta Distorted Sandwich Acetylcholine Binding Protein; Chain: A, Neurotransmitter-gated ion-channel ligand-binding domain 4qaaA00
2XQ6A 2Y58A 3PMZA 2Y7YA 5LG3A 3T4MA 5J0ZA 3RIFA 4UY2A 5IUXA 4IL9A 3LSVA 3TLWA 2YKSA 3WTOA 3RI5A 4WV9A 5JMEA 2BG9C 4ILBA 4IL4A 2QC1B 5HEUA 3UQ4A 2XYSA 5KZUA 2PH9A 4AFTA 5LXBA 5AFKA 4QABA 3ZDGA 3U8LA 3IGQA 4Z91A 5J5FA 2XZ6A 2XQ8A 2Y57A 4NZBA 4HQPA 2ZJVA 5HEJA 4QACA 1I9BA 4XHEA 3WTNA 5AFNA 4LMLA 4TWHA 4A97A 3P50A 2UZ6A 2X00A 2XNVA 2YN6A 2ZJUA 4HFEA 4X5TA 4HFBA 2YMEA 3RIAA 3WTKA 4ILCA 5AFHA 4UM3S 3U8JA 5AFJA 5HEOA 3JAEA 2BYQA 4QH5A 3ZDHA 2BR7A 4F8HA 3UU4A 2WZYA 2XQ7A 4ZK1A 4D01A 2W8FA 1UW6A 2BJ0A 3UU8A 5BP0A 3RHWA 2WNCA 5FJVA 5CO5A 2XQAA 3GUAA 2VL0A 3TLUA 3WIPA 2WN9A 3SH1A 4XK9A 4UXUA 3ZKRA 2BYRA 4BFQA 3WTLA 5HCJA 3U8KA 4ZK4A 2BR8A 5L47A 3U8MA 2Y56A 2XZ5A 3RQWA 2XNTA 2WNJA 3UU6A 3PEOA 5L4HA 4LMKA 5TVCA 4BQTA 3UU3A 2X00D 4ZZBA 5AFLA 2BG9B 4Z90A 2XYTA 4TNVA 3UU5A 2BG9A 3SQ6A 2XQ4A 3UUBA 2BYPA 4TWFA 4UM1A 5SYOA 5AINA 5HEGA 4LMJA 4QH1A 3WTHA 3C79A 4ZRUA 4NPPA 2XNUA 3U8NA 4UM3P 3SIOA 4COFA 4UM3A 2XQ5A 1UX2A 3TLVA 3EHZA 2C9TA 2YMDA 3RQUA 5CFBA 4QAAA 4TNWA 3TLTA 4HFIA 4ZR6A 2BYSA 5HEHA 3WTJA 3WTIA 4QH4A 2WNLA 4EZ1A 4AFGA 4ALXA 5J5IA 4DBMA 2Y54A 4IREA 3C84A 3SQ9A 5L4EA 4ZZCA 5AFMB 2BG9E 4ZJTA 4PIRA 4HFCA 4ILAA 4FRRA 5BRXA 2XQ9A 3EI0A 3JAFA 5J5GA 5AFMA 2W8GA 4AFHA 5KE4A 5J5HA 4HFDA 4A98A 3WTMA 1UV6A 2XQ3A 4ZJSA 3TLSA 3UQ7A 4HFHA 4TWDA 5BW2A 2PGZA 5HCMA 3EAMA 4B5DA 3JADA 2BYNA 2YOEA 3P4WA
chains in the Genus database with same CATH superfamily
2XQ6A 2Y58A 3PMZA 2Y7YA 5LG3A 3T4MA 5J0ZA 3RIFA 4UY2A 5IUXA 4IL9A 3LSVA 3TLWA 2YKSA 3WTOA 3RI5A 4WV9A 5JMEA 2BG9C 4ILBA 4IL4A 2QC1B 5HEUA 3UQ4A 2XYSA 5KZUA 2PH9A 4AFTA 5LXBA 5AFKA 4QABA 3ZDGA 3U8LA 3IGQA 4Z91A 5J5FA 2XZ6A 2XQ8A 2Y57A 4NZBA 4HQPA 2ZJVA 5HEJA 4QACA 1I9BA 4XHEA 3WTNA 5AFNA 4LMLA 4TWHA 4A97A 3P50A 2UZ6A 2X00A 2XNVA 2YN6A 2ZJUA 4HFEA 4X5TA 4HFBA 2YMEA 3RIAA 3WTKA 4ILCA 5AFHA 4UM3S 3U8JA 5AFJA 5HEOA 3JAEA 2BYQA 4QH5A 3ZDHA 2BR7A 4F8HA 3UU4A 2WZYA 2XQ7A 4ZK1A 4D01A 2W8FA 1UW6A 2BJ0A 3UU8A 5BP0A 3RHWA 2WNCA 5FJVA 5CO5A 2XQAA 3GUAA 2VL0A 3TLUA 3WIPA 2WN9A 3SH1A 4XK9A 4UXUA 3ZKRA 2BYRA 4BFQA 3WTLA 5HCJA 3U8KA 4ZK4A 2BR8A 5L47A 3U8MA 2Y56A 2XZ5A 3RQWA 2XNTA 2WNJA 3UU6A 3PEOA 5L4HA 4LMKA 5TVCA 4BQTA 3UU3A 2X00D 4ZZBA 5AFLA 2BG9B 4Z90A 2XYTA 4TNVA 3UU5A 2BG9A 3SQ6A 2XQ4A 3UUBA 2BYPA 4TWFA 4UM1A 5SYOA 5AINA 5HEGA 4LMJA 4QH1A 3WTHA 3C79A 4ZRUA 4NPPA 2XNUA 3U8NA 4UM3P 3SIOA 4COFA 4UM3A 2XQ5A 1UX2A 3TLVA 3EHZA 2C9TA 2YMDA 3RQUA 5CFBA 4QAAA 4TNWA 3TLTA 4HFIA 4ZR6A 2BYSA 5HEHA 3WTJA 3WTIA 4QH4A 2WNLA 4EZ1A 4AFGA 4ALXA 5J5IA 4DBMA 2Y54A 4IREA 3C84A 3SQ9A 5L4EA 4ZZCA 5AFMB 2BG9E 4ZJTA 4PIRA 4HFCA 4ILAA 4FRRA 5BRXA 2XQ9A 3EI0A 3JAFA 5J5GA 5AFMA 2W8GA 4AFHA 5KE4A 5J5HA 4HFDA 4A98A 3WTMA 1UV6A 2XQ3A 4ZJSA 3TLSA 3UQ7A 4HFHA 4TWDA 5BW2A 2PGZA 5HCMA 3EAMA 4B5DA 3JADA 2BYNA 2YOEA 3P4WA
chains in the Genus database with same CATH topology
2XQ6A 2Y58A 3PMZA 2Y7YA 5LG3A 3T4MA 5J0ZA 3RIFA 4UY2A 5IUXA 4IL9A 3LSVA 3TLWA 2YKSA 3WTOA 3RI5A 4WV9A 5JMEA 2BG9C 4ILBA 4IL4A 2QC1B 5HEUA 3UQ4A 2XYSA 5KZUA 2PH9A 4AFTA 5LXBA 5AFKA 4QABA 3ZDGA 3U8LA 3IGQA 4Z91A 5J5FA 2XZ6A 2XQ8A 2Y57A 4NZBA 4HQPA 2ZJVA 5HEJA 4QACA 1I9BA 4XHEA 3WTNA 5AFNA 4LMLA 4TWHA 4A97A 3P50A 2UZ6A 2X00A 2XNVA 2YN6A 2ZJUA 4HFEA 4X5TA 4HFBA 2YMEA 3RIAA 3WTKA 4ILCA 5AFHA 4UM3S 3U8JA 5AFJA 5HEOA 3JAEA 2BYQA 4QH5A 3ZDHA 2BR7A 4F8HA 3UU4A 2WZYA 2XQ7A 4ZK1A 4D01A 2W8FA 1UW6A 2BJ0A 3UU8A 5BP0A 3RHWA 2WNCA 5FJVA 5CO5A 2XQAA 3GUAA 2VL0A 3TLUA 3WIPA 2WN9A 3SH1A 4XK9A 4UXUA 3ZKRA 2BYRA 4BFQA 3WTLA 5HCJA 3U8KA 4ZK4A 2BR8A 5L47A 3U8MA 2Y56A 2XZ5A 3RQWA 2XNTA 2WNJA 3UU6A 3PEOA 5L4HA 4LMKA 5TVCA 4BQTA 3UU3A 2X00D 4ZZBA 5AFLA 2BG9B 4Z90A 2XYTA 4TNVA 3UU5A 2BG9A 3SQ6A 2XQ4A 3UUBA 2BYPA 4TWFA 4UM1A 5SYOA 5AINA 5HEGA 4LMJA 4QH1A 3WTHA 3C79A 4ZRUA 4NPPA 2XNUA 3U8NA 4UM3P 3SIOA 4COFA 4UM3A 2XQ5A 1UX2A 3TLVA 3EHZA 2C9TA 2YMDA 3RQUA 5CFBA 4QAAA 4TNWA 3TLTA 4HFIA 4ZR6A 2BYSA 5HEHA 3WTJA 3WTIA 4QH4A 2WNLA 4EZ1A 4AFGA 4ALXA 5J5IA 4DBMA 2Y54A 4IREA 3C84A 3SQ9A 5L4EA 4ZZCA 5AFMB 2BG9E 4ZJTA 4PIRA 4HFCA 4ILAA 4FRRA 5BRXA 2XQ9A 3EI0A 3JAFA 5J5GA 5AFMA 2W8GA 4AFHA 5KE4A 5J5HA 4HFDA 4A98A 3WTMA 1UV6A 2XQ3A 4ZJSA 3TLSA 3UQ7A 4HFHA 4TWDA 5BW2A 2PGZA 5HCMA 3EAMA 4B5DA 3JADA 2BYNA 2YOEA 3P4WA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2XQ6 A;  2Y58 A;  3PMZ A;  2Y7Y A;  5LG3 A;  3T4M A;  5J0Z A;  3RIF A;  4UY2 A;  5IUX A;  4IL9 A;  3LSV A;  3TLW A;  2YKS A;  3WTO A;  3RI5 A;  4WV9 A;  5JME A;  2BG9 C;  4ILB A;  4IL4 A;  2QC1 B;  5HEU A;  3UQ4 A;  2XYS A;  5KZU A;  2PH9 A;  4AFT A;  5LXB A;  5AFK A;  4QAB A;  3ZDG A;  3U8L A;  3IGQ A;  4Z91 A;  5J5F A;  2XZ6 A;  2XQ8 A;  2Y57 A;  4NZB A;  4HQP A;  2ZJV A;  5HEJ A;  4QAC A;  1I9B A;  4XHE A;  3WTN A;  5AFN A;  4LML A;  4TWH A;  4A97 A;  3P50 A;  2UZ6 A;  2X00 A;  2XNV A;  2YN6 A;  2ZJU A;  4HFE A;  4X5T A;  4HFB A;  2YME A;  3RIA A;  3WTK A;  4ILC A;  5AFH A;  4UM3 S;  3U8J A;  5AFJ A;  5HEO A;  3JAE A;  2BYQ A;  4QH5 A;  3ZDH A;  2BR7 A;  4F8H A;  3UU4 A;  2WZY A;  2XQ7 A;  4ZK1 A;  4D01 A;  2W8F A;  1UW6 A;  2BJ0 A;  3UU8 A;  5BP0 A;  3RHW A;  2WNC A;  5FJV A;  5CO5 A;  2XQA A;  3GUA A;  2VL0 A;  3TLU A;  3WIP A;  2WN9 A;  3SH1 A;  4XK9 A;  4UXU A;  3ZKR A;  2BYR A;  4BFQ A;  3WTL A;  5HCJ A;  3U8K A;  4ZK4 A;  2BR8 A;  5L47 A;  3U8M A;  2Y56 A;  2XZ5 A;  3RQW A;  2XNT A;  2WNJ A;  3UU6 A;  3PEO A;  5L4H A;  4LMK A;  5TVC A;  4BQT A;  3UU3 A;  2X00 D;  4ZZB A;  5AFL A;  2BG9 B;  4Z90 A;  2XYT A;  4TNV A;  3UU5 A;  2BG9 A;  3SQ6 A;  2XQ4 A;  3UUB A;  2BYP A;  4TWF A;  4UM1 A;  5SYO A;  5AIN A;  5HEG A;  4LMJ A;  4QH1 A;  3WTH A;  3C79 A;  4ZRU A;  4NPP A;  2XNU A;  3U8N A;  4UM3 P;  3SIO A;  4COF A;  4UM3 A;  2XQ5 A;  1UX2 A;  3TLV A;  3EHZ A;  2C9T A;  2YMD A;  3RQU A;  5CFB A;  4QAA A;  4TNW A;  3TLT A;  4HFI A;  4ZR6 A;  2BYS A;  5HEH A;  3WTJ A;  3WTI A;  4QH4 A;  2WNL A;  4EZ1 A;  4AFG A;  4ALX A;  5J5I A;  4DBM A;  2Y54 A;  4IRE A;  3C84 A;  3SQ9 A;  5L4E A;  4ZZC A;  5AFM B;  2BG9 E;  4ZJT A;  4PIR A;  4HFC A;  4ILA A;  4FRR A;  5BRX A;  2XQ9 A;  3EI0 A;  3JAF A;  5J5G A;  5AFM A;  2W8G A;  4AFH A;  5KE4 A;  5J5H A;  4HFD A;  4A98 A;  3WTM A;  1UV6 A;  2XQ3 A;  4ZJS A;  3TLS A;  3UQ7 A;  4HFH A;  4TWD A;  5BW2 A;  2PGZ A;  5HCM A;  3EAM A;  4B5D A;  3JAD A;  2BYN A;  2YOE A;  3P4W A; 
#chains in the Genus database with same CATH topology
 2XQ6 A;  2Y58 A;  3PMZ A;  2Y7Y A;  5LG3 A;  3T4M A;  5J0Z A;  3RIF A;  4UY2 A;  5IUX A;  4IL9 A;  3LSV A;  3TLW A;  2YKS A;  3WTO A;  3RI5 A;  4WV9 A;  5JME A;  2BG9 C;  4ILB A;  4IL4 A;  2QC1 B;  5HEU A;  3UQ4 A;  2XYS A;  5KZU A;  2PH9 A;  4AFT A;  5LXB A;  5AFK A;  4QAB A;  3ZDG A;  3U8L A;  3IGQ A;  4Z91 A;  5J5F A;  2XZ6 A;  2XQ8 A;  2Y57 A;  4NZB A;  4HQP A;  2ZJV A;  5HEJ A;  4QAC A;  1I9B A;  4XHE A;  3WTN A;  5AFN A;  4LML A;  4TWH A;  4A97 A;  3P50 A;  2UZ6 A;  2X00 A;  2XNV A;  2YN6 A;  2ZJU A;  4HFE A;  4X5T A;  4HFB A;  2YME A;  3RIA A;  3WTK A;  4ILC A;  5AFH A;  4UM3 S;  3U8J A;  5AFJ A;  5HEO A;  3JAE A;  2BYQ A;  4QH5 A;  3ZDH A;  2BR7 A;  4F8H A;  3UU4 A;  2WZY A;  2XQ7 A;  4ZK1 A;  4D01 A;  2W8F A;  1UW6 A;  2BJ0 A;  3UU8 A;  5BP0 A;  3RHW A;  2WNC A;  5FJV A;  5CO5 A;  2XQA A;  3GUA A;  2VL0 A;  3TLU A;  3WIP A;  2WN9 A;  3SH1 A;  4XK9 A;  4UXU A;  3ZKR A;  2BYR A;  4BFQ A;  3WTL A;  5HCJ A;  3U8K A;  4ZK4 A;  2BR8 A;  5L47 A;  3U8M A;  2Y56 A;  2XZ5 A;  3RQW A;  2XNT A;  2WNJ A;  3UU6 A;  3PEO A;  5L4H A;  4LMK A;  5TVC A;  4BQT A;  3UU3 A;  2X00 D;  4ZZB A;  5AFL A;  2BG9 B;  4Z90 A;  2XYT A;  4TNV A;  3UU5 A;  2BG9 A;  3SQ6 A;  2XQ4 A;  3UUB A;  2BYP A;  4TWF A;  4UM1 A;  5SYO A;  5AIN A;  5HEG A;  4LMJ A;  4QH1 A;  3WTH A;  3C79 A;  4ZRU A;  4NPP A;  2XNU A;  3U8N A;  4UM3 P;  3SIO A;  4COF A;  4UM3 A;  2XQ5 A;  1UX2 A;  3TLV A;  3EHZ A;  2C9T A;  2YMD A;  3RQU A;  5CFB A;  4QAA A;  4TNW A;  3TLT A;  4HFI A;  4ZR6 A;  2BYS A;  5HEH A;  3WTJ A;  3WTI A;  4QH4 A;  2WNL A;  4EZ1 A;  4AFG A;  4ALX A;  5J5I A;  4DBM A;  2Y54 A;  4IRE A;  3C84 A;  3SQ9 A;  5L4E A;  4ZZC A;  5AFM B;  2BG9 E;  4ZJT A;  4PIR A;  4HFC A;  4ILA A;  4FRR A;  5BRX A;  2XQ9 A;  3EI0 A;  3JAF A;  5J5G A;  5AFM A;  2W8G A;  4AFH A;  5KE4 A;  5J5H A;  4HFD A;  4A98 A;  3WTM A;  1UV6 A;  2XQ3 A;  4ZJS A;  3TLS A;  3UQ7 A;  4HFH A;  4TWD A;  5BW2 A;  2PGZ A;  5HCM A;  3EAM A;  4B5D A;  3JAD A;  2BYN A;  2YOE A;  3P4W A; 
#chains in the Genus database with same CATH homology
 2XQ6 A;  2Y58 A;  3PMZ A;  2Y7Y A;  5LG3 A;  3T4M A;  5J0Z A;  3RIF A;  4UY2 A;  5IUX A;  4IL9 A;  3LSV A;  3TLW A;  2YKS A;  3WTO A;  3RI5 A;  4WV9 A;  5JME A;  2BG9 C;  4ILB A;  4IL4 A;  2QC1 B;  5HEU A;  3UQ4 A;  2XYS A;  5KZU A;  2PH9 A;  4AFT A;  5LXB A;  5AFK A;  4QAB A;  3ZDG A;  3U8L A;  3IGQ A;  4Z91 A;  5J5F A;  2XZ6 A;  2XQ8 A;  2Y57 A;  4NZB A;  4HQP A;  2ZJV A;  5HEJ A;  4QAC A;  1I9B A;  4XHE A;  3WTN A;  5AFN A;  4LML A;  4TWH A;  4A97 A;  3P50 A;  2UZ6 A;  2X00 A;  2XNV A;  2YN6 A;  2ZJU A;  4HFE A;  4X5T A;  4HFB A;  2YME A;  3RIA A;  3WTK A;  4ILC A;  5AFH A;  4UM3 S;  3U8J A;  5AFJ A;  5HEO A;  3JAE A;  2BYQ A;  4QH5 A;  3ZDH A;  2BR7 A;  4F8H A;  3UU4 A;  2WZY A;  2XQ7 A;  4ZK1 A;  4D01 A;  2W8F A;  1UW6 A;  2BJ0 A;  3UU8 A;  5BP0 A;  3RHW A;  2WNC A;  5FJV A;  5CO5 A;  2XQA A;  3GUA A;  2VL0 A;  3TLU A;  3WIP A;  2WN9 A;  3SH1 A;  4XK9 A;  4UXU A;  3ZKR A;  2BYR A;  4BFQ A;  3WTL A;  5HCJ A;  3U8K A;  4ZK4 A;  2BR8 A;  5L47 A;  3U8M A;  2Y56 A;  2XZ5 A;  3RQW A;  2XNT A;  2WNJ A;  3UU6 A;  3PEO A;  5L4H A;  4LMK A;  5TVC A;  4BQT A;  3UU3 A;  2X00 D;  4ZZB A;  5AFL A;  2BG9 B;  4Z90 A;  2XYT A;  4TNV A;  3UU5 A;  2BG9 A;  3SQ6 A;  2XQ4 A;  3UUB A;  2BYP A;  4TWF A;  4UM1 A;  5SYO A;  5AIN A;  5HEG A;  4LMJ A;  4QH1 A;  3WTH A;  3C79 A;  4ZRU A;  4NPP A;  2XNU A;  3U8N A;  4UM3 P;  3SIO A;  4COF A;  4UM3 A;  2XQ5 A;  1UX2 A;  3TLV A;  3EHZ A;  2C9T A;  2YMD A;  3RQU A;  5CFB A;  4QAA A;  4TNW A;  3TLT A;  4HFI A;  4ZR6 A;  2BYS A;  5HEH A;  3WTJ A;  3WTI A;  4QH4 A;  2WNL A;  4EZ1 A;  4AFG A;  4ALX A;  5J5I A;  4DBM A;  2Y54 A;  4IRE A;  3C84 A;  3SQ9 A;  5L4E A;  4ZZC A;  5AFM B;  2BG9 E;  4ZJT A;  4PIR A;  4HFC A;  4ILA A;  4FRR A;  5BRX A;  2XQ9 A;  3EI0 A;  3JAF A;  5J5G A;  5AFM A;  2W8G A;  4AFH A;  5KE4 A;  5J5H A;  4HFD A;  4A98 A;  3WTM A;  1UV6 A;  2XQ3 A;  4ZJS A;  3TLS A;  3UQ7 A;  4HFH A;  4TWD A;  5BW2 A;  2PGZ A;  5HCM A;  3EAM A;  4B5D A;  3JAD A;  2BYN A;  2YOE A;  3P4W A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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