3SIOA

Ac-achbp ligand binding domain (not including beta 9-10 linker) mutated to human alpha-7 nachr
Total Genus 53
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
53
sequence length
214
structure length
214
Chain Sequence
KDDDDKLHSQANLMRLKSDLFNRSPMYPGPTKDDPLTVYLSFSLLDIVKADSSTNEVDLVYWEQQSWKLNSLMWDPNEYGNITDFRTSAADIWTPDITAYSSTRPVQVLSPQNALVNSSGHVQYLPAQRLSFMCDPTGVDSEEGATCAVKFGSWSYGGWEIDLKTDTDQVDLSSYYASSKYEILSATQTRQVQHYSCCPEPYIDVNLVVKFRER
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Creating an alpha-7 nicotinic acetylcholine recognition domain from the acetylcholine binding protein: crystallographic and ligand selectivity analyses
pubmed doi rcsb
molecule tags Receptor
source organism Aplysia californica
molecule keywords Soluble acetylcholine receptor
total genus 53
structure length 214
sequence length 214
chains with identical sequence B, C, D, E, F, G, H, I, J
ec nomenclature
pdb deposition date 2011-06-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02931 Neur_chan_LBD Neurotransmitter-gated ion-channel ligand binding domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.170.10 Mainly Beta Distorted Sandwich Acetylcholine Binding Protein; Chain: A, Neurotransmitter-gated ion-channel ligand-binding domain 3sioA00
2BYPA 4Z91A 3SIOA 5AFMB 2XYTA 4AFGA 5J5FA 2Y56A 5AFKA 2BR7A 4LMLA 2XQ9A 3ZDGA 1UV6A 3T4MA 5LXBA 3EAMA 4AFHA 4UM3P 4ZRUA 2BG9E 3RQUA 3WTMA 2BG9C 2XNVA 2XQ7A 3JAEA 5TVCA 5AFLA 3U8KA 3TLTA 3UU4A 2W8FA 4UXUA 3WTLA 3ZDHA 4B5DA 2YMDA 4HQPA 2XYSA 4ZZBA 4HFHA 4UY2A 2WN9A 4PIRA 4QH1A 5BW2A 5KE4A 3WTNA 4XK9A 5FJVA 3U8NA 3UU5A 2BG9A 3TLSA 3WTIA 4TNVA 4A98A 2ZJVA 3JADA 2VL0A 4TNWA 3EHZA 2QC1B 4ZK4A 5AFHA 4IL4A 3WTHA 2XQ8A 5CO5A 5HCJA 2XQ4A 4ZJTA 2BR8A 5AFJA 1UX2A 2XZ6A 2X00D 3IGQA 4ZR6A 4ZZCA 2XNTA 3TLVA 3C79A 4HFEA 5HEOA 3C84A 3PMZA 5L4HA 5JMEA 3WTOA 4DBMA 2UZ6A 4BQTA 5BP0A 5LG3A 4WV9A 5J5GA 3UU3A 4AFTA 4EZ1A 5HCMA 3SQ9A 2PGZA 4QH4A 5AINA 2WNLA 2XQ6A 5HEJA 4HFCA 2XQ5A 3WIPA 4HFBA 3UUBA 2Y57A 4TWDA 2YOEA 3TLWA 3P50A 2BYRA 3EI0A 3UQ4A 2C9TA 3ZKRA 4ALXA 5HEHA 5SYOA 2WNCA 2YMEA 2XNUA 5IUXA 4F8HA 5AFMA 3LSVA 4NZBA 3SQ6A 4COFA 1UW6A 5HEGA 4FRRA 4IL9A 4ILAA 3U8LA 4D01A 5L4EA 4NPPA 2BJ0A 4UM3A 2BYSA 2PH9A 3SH1A 3U8MA 2Y58A 1I9BA 2ZJUA 3WTJA 3RHWA 2BYNA 4QAAA 4ZJSA 2YKSA 2XQAA 3UU6A 3U8JA 4QACA 4HFIA 4UM3S 3RQWA 2Y54A 4ILBA 4Z90A 2BYQA 4XHEA 4A97A 4QABA 2X00A 3RIFA 2XZ5A 3PEOA 2WNJA 4TWHA 4ILCA 3RIAA 5CFBA 4LMKA 4QH5A 4LMJA 3JAFA 3UQ7A 5KZUA 2BG9B 5HEUA 5J5IA 3TLUA 5J0ZA 3WTKA 2W8GA 4IREA 2WZYA 3RI5A 2YN6A 3UU8A 4ZK1A 3GUAA 5BRXA 4UM1A 4BFQA 5AFNA 5J5HA 5L47A 2XQ3A 3P4WA 4X5TA 2Y7YA 4TWFA 4HFDA
chains in the Genus database with same CATH superfamily
2BYPA 4Z91A 3SIOA 5AFMB 2XYTA 4AFGA 5J5FA 2Y56A 5AFKA 2BR7A 4LMLA 2XQ9A 3ZDGA 1UV6A 3T4MA 5LXBA 3EAMA 4AFHA 4UM3P 4ZRUA 2BG9E 3RQUA 3WTMA 2BG9C 2XNVA 2XQ7A 3JAEA 5TVCA 5AFLA 3U8KA 3TLTA 3UU4A 2W8FA 4UXUA 3WTLA 3ZDHA 4B5DA 2YMDA 4HQPA 2XYSA 4ZZBA 4HFHA 4UY2A 2WN9A 4PIRA 4QH1A 5BW2A 5KE4A 3WTNA 4XK9A 5FJVA 3U8NA 3UU5A 2BG9A 3TLSA 3WTIA 4TNVA 4A98A 2ZJVA 3JADA 2VL0A 4TNWA 3EHZA 2QC1B 4ZK4A 5AFHA 4IL4A 3WTHA 2XQ8A 5CO5A 5HCJA 2XQ4A 4ZJTA 2BR8A 5AFJA 1UX2A 2XZ6A 2X00D 3IGQA 4ZR6A 4ZZCA 2XNTA 3TLVA 3C79A 4HFEA 5HEOA 3C84A 3PMZA 5L4HA 5JMEA 3WTOA 4DBMA 2UZ6A 4BQTA 5BP0A 5LG3A 4WV9A 5J5GA 3UU3A 4AFTA 4EZ1A 5HCMA 3SQ9A 2PGZA 4QH4A 5AINA 2WNLA 2XQ6A 5HEJA 4HFCA 2XQ5A 3WIPA 4HFBA 3UUBA 2Y57A 4TWDA 2YOEA 3TLWA 3P50A 2BYRA 3EI0A 3UQ4A 2C9TA 3ZKRA 4ALXA 5HEHA 5SYOA 2WNCA 2YMEA 2XNUA 5IUXA 4F8HA 5AFMA 3LSVA 4NZBA 3SQ6A 4COFA 1UW6A 5HEGA 4FRRA 4IL9A 4ILAA 3U8LA 4D01A 5L4EA 4NPPA 2BJ0A 4UM3A 2BYSA 2PH9A 3SH1A 3U8MA 2Y58A 1I9BA 2ZJUA 3WTJA 3RHWA 2BYNA 4QAAA 4ZJSA 2YKSA 2XQAA 3UU6A 3U8JA 4QACA 4HFIA 4UM3S 3RQWA 2Y54A 4ILBA 4Z90A 2BYQA 4XHEA 4A97A 4QABA 2X00A 3RIFA 2XZ5A 3PEOA 2WNJA 4TWHA 4ILCA 3RIAA 5CFBA 4LMKA 4QH5A 4LMJA 3JAFA 3UQ7A 5KZUA 2BG9B 5HEUA 5J5IA 3TLUA 5J0ZA 3WTKA 2W8GA 4IREA 2WZYA 3RI5A 2YN6A 3UU8A 4ZK1A 3GUAA 5BRXA 4UM1A 4BFQA 5AFNA 5J5HA 5L47A 2XQ3A 3P4WA 4X5TA 2Y7YA 4TWFA 4HFDA
chains in the Genus database with same CATH topology
2BYPA 4Z91A 3SIOA 5AFMB 2XYTA 4AFGA 5J5FA 2Y56A 5AFKA 2BR7A 4LMLA 2XQ9A 3ZDGA 1UV6A 3T4MA 5LXBA 3EAMA 4AFHA 4UM3P 4ZRUA 2BG9E 3RQUA 3WTMA 2BG9C 2XNVA 2XQ7A 3JAEA 5TVCA 5AFLA 3U8KA 3TLTA 3UU4A 2W8FA 4UXUA 3WTLA 3ZDHA 4B5DA 2YMDA 4HQPA 2XYSA 4ZZBA 4HFHA 4UY2A 2WN9A 4PIRA 4QH1A 5BW2A 5KE4A 3WTNA 4XK9A 5FJVA 3U8NA 3UU5A 2BG9A 3TLSA 3WTIA 4TNVA 4A98A 2ZJVA 3JADA 2VL0A 4TNWA 3EHZA 2QC1B 4ZK4A 5AFHA 4IL4A 3WTHA 2XQ8A 5CO5A 5HCJA 2XQ4A 4ZJTA 2BR8A 5AFJA 1UX2A 2XZ6A 2X00D 3IGQA 4ZR6A 4ZZCA 2XNTA 3TLVA 3C79A 4HFEA 5HEOA 3C84A 3PMZA 5L4HA 5JMEA 3WTOA 4DBMA 2UZ6A 4BQTA 5BP0A 5LG3A 4WV9A 5J5GA 3UU3A 4AFTA 4EZ1A 5HCMA 3SQ9A 2PGZA 4QH4A 5AINA 2WNLA 2XQ6A 5HEJA 4HFCA 2XQ5A 3WIPA 4HFBA 3UUBA 2Y57A 4TWDA 2YOEA 3TLWA 3P50A 2BYRA 3EI0A 3UQ4A 2C9TA 3ZKRA 4ALXA 5HEHA 5SYOA 2WNCA 2YMEA 2XNUA 5IUXA 4F8HA 5AFMA 3LSVA 4NZBA 3SQ6A 4COFA 1UW6A 5HEGA 4FRRA 4IL9A 4ILAA 3U8LA 4D01A 5L4EA 4NPPA 2BJ0A 4UM3A 2BYSA 2PH9A 3SH1A 3U8MA 2Y58A 1I9BA 2ZJUA 3WTJA 3RHWA 2BYNA 4QAAA 4ZJSA 2YKSA 2XQAA 3UU6A 3U8JA 4QACA 4HFIA 4UM3S 3RQWA 2Y54A 4ILBA 4Z90A 2BYQA 4XHEA 4A97A 4QABA 2X00A 3RIFA 2XZ5A 3PEOA 2WNJA 4TWHA 4ILCA 3RIAA 5CFBA 4LMKA 4QH5A 4LMJA 3JAFA 3UQ7A 5KZUA 2BG9B 5HEUA 5J5IA 3TLUA 5J0ZA 3WTKA 2W8GA 4IREA 2WZYA 3RI5A 2YN6A 3UU8A 4ZK1A 3GUAA 5BRXA 4UM1A 4BFQA 5AFNA 5J5HA 5L47A 2XQ3A 3P4WA 4X5TA 2Y7YA 4TWFA 4HFDA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2BYP A;  4Z91 A;  3SIO A;  5AFM B;  2XYT A;  4AFG A;  5J5F A;  2Y56 A;  5AFK A;  2BR7 A;  4LML A;  2XQ9 A;  3ZDG A;  1UV6 A;  3T4M A;  5LXB A;  3EAM A;  4AFH A;  4UM3 P;  4ZRU A;  2BG9 E;  3RQU A;  3WTM A;  2BG9 C;  2XNV A;  2XQ7 A;  3JAE A;  5TVC A;  5AFL A;  3U8K A;  3TLT A;  3UU4 A;  2W8F A;  4UXU A;  3WTL A;  3ZDH A;  4B5D A;  2YMD A;  4HQP A;  2XYS A;  4ZZB A;  4HFH A;  4UY2 A;  2WN9 A;  4PIR A;  4QH1 A;  5BW2 A;  5KE4 A;  3WTN A;  4XK9 A;  5FJV A;  3U8N A;  3UU5 A;  2BG9 A;  3TLS A;  3WTI A;  4TNV A;  4A98 A;  2ZJV A;  3JAD A;  2VL0 A;  4TNW A;  3EHZ A;  2QC1 B;  4ZK4 A;  5AFH A;  4IL4 A;  3WTH A;  2XQ8 A;  5CO5 A;  5HCJ A;  2XQ4 A;  4ZJT A;  2BR8 A;  5AFJ A;  1UX2 A;  2XZ6 A;  2X00 D;  3IGQ A;  4ZR6 A;  4ZZC A;  2XNT A;  3TLV A;  3C79 A;  4HFE A;  5HEO A;  3C84 A;  3PMZ A;  5L4H A;  5JME A;  3WTO A;  4DBM A;  2UZ6 A;  4BQT A;  5BP0 A;  5LG3 A;  4WV9 A;  5J5G A;  3UU3 A;  4AFT A;  4EZ1 A;  5HCM A;  3SQ9 A;  2PGZ A;  4QH4 A;  5AIN A;  2WNL A;  2XQ6 A;  5HEJ A;  4HFC A;  2XQ5 A;  3WIP A;  4HFB A;  3UUB A;  2Y57 A;  4TWD A;  2YOE A;  3TLW A;  3P50 A;  2BYR A;  3EI0 A;  3UQ4 A;  2C9T A;  3ZKR A;  4ALX A;  5HEH A;  5SYO A;  2WNC A;  2YME A;  2XNU A;  5IUX A;  4F8H A;  5AFM A;  3LSV A;  4NZB A;  3SQ6 A;  4COF A;  1UW6 A;  5HEG A;  4FRR A;  4IL9 A;  4ILA A;  3U8L A;  4D01 A;  5L4E A;  4NPP A;  2BJ0 A;  4UM3 A;  2BYS A;  2PH9 A;  3SH1 A;  3U8M A;  2Y58 A;  1I9B A;  2ZJU A;  3WTJ A;  3RHW A;  2BYN A;  4QAA A;  4ZJS A;  2YKS A;  2XQA A;  3UU6 A;  3U8J A;  4QAC A;  4HFI A;  4UM3 S;  3RQW A;  2Y54 A;  4ILB A;  4Z90 A;  2BYQ A;  4XHE A;  4A97 A;  4QAB A;  2X00 A;  3RIF A;  2XZ5 A;  3PEO A;  2WNJ A;  4TWH A;  4ILC A;  3RIA A;  5CFB A;  4LMK A;  4QH5 A;  4LMJ A;  3JAF A;  3UQ7 A;  5KZU A;  2BG9 B;  5HEU A;  5J5I A;  3TLU A;  5J0Z A;  3WTK A;  2W8G A;  4IRE A;  2WZY A;  3RI5 A;  2YN6 A;  3UU8 A;  4ZK1 A;  3GUA A;  5BRX A;  4UM1 A;  4BFQ A;  5AFN A;  5J5H A;  5L47 A;  2XQ3 A;  3P4W A;  4X5T A;  2Y7Y A;  4TWF A;  4HFD A; 
#chains in the Genus database with same CATH topology
 2BYP A;  4Z91 A;  3SIO A;  5AFM B;  2XYT A;  4AFG A;  5J5F A;  2Y56 A;  5AFK A;  2BR7 A;  4LML A;  2XQ9 A;  3ZDG A;  1UV6 A;  3T4M A;  5LXB A;  3EAM A;  4AFH A;  4UM3 P;  4ZRU A;  2BG9 E;  3RQU A;  3WTM A;  2BG9 C;  2XNV A;  2XQ7 A;  3JAE A;  5TVC A;  5AFL A;  3U8K A;  3TLT A;  3UU4 A;  2W8F A;  4UXU A;  3WTL A;  3ZDH A;  4B5D A;  2YMD A;  4HQP A;  2XYS A;  4ZZB A;  4HFH A;  4UY2 A;  2WN9 A;  4PIR A;  4QH1 A;  5BW2 A;  5KE4 A;  3WTN A;  4XK9 A;  5FJV A;  3U8N A;  3UU5 A;  2BG9 A;  3TLS A;  3WTI A;  4TNV A;  4A98 A;  2ZJV A;  3JAD A;  2VL0 A;  4TNW A;  3EHZ A;  2QC1 B;  4ZK4 A;  5AFH A;  4IL4 A;  3WTH A;  2XQ8 A;  5CO5 A;  5HCJ A;  2XQ4 A;  4ZJT A;  2BR8 A;  5AFJ A;  1UX2 A;  2XZ6 A;  2X00 D;  3IGQ A;  4ZR6 A;  4ZZC A;  2XNT A;  3TLV A;  3C79 A;  4HFE A;  5HEO A;  3C84 A;  3PMZ A;  5L4H A;  5JME A;  3WTO A;  4DBM A;  2UZ6 A;  4BQT A;  5BP0 A;  5LG3 A;  4WV9 A;  5J5G A;  3UU3 A;  4AFT A;  4EZ1 A;  5HCM A;  3SQ9 A;  2PGZ A;  4QH4 A;  5AIN A;  2WNL A;  2XQ6 A;  5HEJ A;  4HFC A;  2XQ5 A;  3WIP A;  4HFB A;  3UUB A;  2Y57 A;  4TWD A;  2YOE A;  3TLW A;  3P50 A;  2BYR A;  3EI0 A;  3UQ4 A;  2C9T A;  3ZKR A;  4ALX A;  5HEH A;  5SYO A;  2WNC A;  2YME A;  2XNU A;  5IUX A;  4F8H A;  5AFM A;  3LSV A;  4NZB A;  3SQ6 A;  4COF A;  1UW6 A;  5HEG A;  4FRR A;  4IL9 A;  4ILA A;  3U8L A;  4D01 A;  5L4E A;  4NPP A;  2BJ0 A;  4UM3 A;  2BYS A;  2PH9 A;  3SH1 A;  3U8M A;  2Y58 A;  1I9B A;  2ZJU A;  3WTJ A;  3RHW A;  2BYN A;  4QAA A;  4ZJS A;  2YKS A;  2XQA A;  3UU6 A;  3U8J A;  4QAC A;  4HFI A;  4UM3 S;  3RQW A;  2Y54 A;  4ILB A;  4Z90 A;  2BYQ A;  4XHE A;  4A97 A;  4QAB A;  2X00 A;  3RIF A;  2XZ5 A;  3PEO A;  2WNJ A;  4TWH A;  4ILC A;  3RIA A;  5CFB A;  4LMK A;  4QH5 A;  4LMJ A;  3JAF A;  3UQ7 A;  5KZU A;  2BG9 B;  5HEU A;  5J5I A;  3TLU A;  5J0Z A;  3WTK A;  2W8G A;  4IRE A;  2WZY A;  3RI5 A;  2YN6 A;  3UU8 A;  4ZK1 A;  3GUA A;  5BRX A;  4UM1 A;  4BFQ A;  5AFN A;  5J5H A;  5L47 A;  2XQ3 A;  3P4W A;  4X5T A;  2Y7Y A;  4TWF A;  4HFD A; 
#chains in the Genus database with same CATH homology
 2BYP A;  4Z91 A;  3SIO A;  5AFM B;  2XYT A;  4AFG A;  5J5F A;  2Y56 A;  5AFK A;  2BR7 A;  4LML A;  2XQ9 A;  3ZDG A;  1UV6 A;  3T4M A;  5LXB A;  3EAM A;  4AFH A;  4UM3 P;  4ZRU A;  2BG9 E;  3RQU A;  3WTM A;  2BG9 C;  2XNV A;  2XQ7 A;  3JAE A;  5TVC A;  5AFL A;  3U8K A;  3TLT A;  3UU4 A;  2W8F A;  4UXU A;  3WTL A;  3ZDH A;  4B5D A;  2YMD A;  4HQP A;  2XYS A;  4ZZB A;  4HFH A;  4UY2 A;  2WN9 A;  4PIR A;  4QH1 A;  5BW2 A;  5KE4 A;  3WTN A;  4XK9 A;  5FJV A;  3U8N A;  3UU5 A;  2BG9 A;  3TLS A;  3WTI A;  4TNV A;  4A98 A;  2ZJV A;  3JAD A;  2VL0 A;  4TNW A;  3EHZ A;  2QC1 B;  4ZK4 A;  5AFH A;  4IL4 A;  3WTH A;  2XQ8 A;  5CO5 A;  5HCJ A;  2XQ4 A;  4ZJT A;  2BR8 A;  5AFJ A;  1UX2 A;  2XZ6 A;  2X00 D;  3IGQ A;  4ZR6 A;  4ZZC A;  2XNT A;  3TLV A;  3C79 A;  4HFE A;  5HEO A;  3C84 A;  3PMZ A;  5L4H A;  5JME A;  3WTO A;  4DBM A;  2UZ6 A;  4BQT A;  5BP0 A;  5LG3 A;  4WV9 A;  5J5G A;  3UU3 A;  4AFT A;  4EZ1 A;  5HCM A;  3SQ9 A;  2PGZ A;  4QH4 A;  5AIN A;  2WNL A;  2XQ6 A;  5HEJ A;  4HFC A;  2XQ5 A;  3WIP A;  4HFB A;  3UUB A;  2Y57 A;  4TWD A;  2YOE A;  3TLW A;  3P50 A;  2BYR A;  3EI0 A;  3UQ4 A;  2C9T A;  3ZKR A;  4ALX A;  5HEH A;  5SYO A;  2WNC A;  2YME A;  2XNU A;  5IUX A;  4F8H A;  5AFM A;  3LSV A;  4NZB A;  3SQ6 A;  4COF A;  1UW6 A;  5HEG A;  4FRR A;  4IL9 A;  4ILA A;  3U8L A;  4D01 A;  5L4E A;  4NPP A;  2BJ0 A;  4UM3 A;  2BYS A;  2PH9 A;  3SH1 A;  3U8M A;  2Y58 A;  1I9B A;  2ZJU A;  3WTJ A;  3RHW A;  2BYN A;  4QAA A;  4ZJS A;  2YKS A;  2XQA A;  3UU6 A;  3U8J A;  4QAC A;  4HFI A;  4UM3 S;  3RQW A;  2Y54 A;  4ILB A;  4Z90 A;  2BYQ A;  4XHE A;  4A97 A;  4QAB A;  2X00 A;  3RIF A;  2XZ5 A;  3PEO A;  2WNJ A;  4TWH A;  4ILC A;  3RIA A;  5CFB A;  4LMK A;  4QH5 A;  4LMJ A;  3JAF A;  3UQ7 A;  5KZU A;  2BG9 B;  5HEU A;  5J5I A;  3TLU A;  5J0Z A;  3WTK A;  2W8G A;  4IRE A;  2WZY A;  3RI5 A;  2YN6 A;  3UU8 A;  4ZK1 A;  3GUA A;  5BRX A;  4UM1 A;  4BFQ A;  5AFN A;  5J5H A;  5L47 A;  2XQ3 A;  3P4W A;  4X5T A;  2Y7Y A;  4TWF A;  4HFD A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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