2XNTA

Acetylcholine binding protein (achbp) as template for hierarchical in silico screening procedures to identify structurally novel ligands for the nicotinic receptors
Total Genus 47
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
47
sequence length
205
structure length
205
Chain Sequence
QANLMRLKSDLFNRSPMYPGPTKDDPLTVTLGFTLQDIVKVDSSTNEVDLVYYEQQRWKLNSLMWDPNEYGNITDFRTSAADIWTPDITAYSSTRPVQVLSPQIAVVTHDGSVMFIPAQRLSFMCDPTGVDSEEGVTCAVKFGSWVYSGFEIDLKTDTDQVDLSSYYASSKYEILSATQTRQVQHYSCCPEPYIDVNLVVKFRER
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Acetylcholine Binding Protein (Achbp) as Template for Hierarchical in Silico Screening Procedures to Identify Structurally Novel Ligands for the Nicotinic Receptors.
pubmed doi rcsb
molecule tags Receptor
source organism Aplysia californica
molecule keywords SOLUBLE ACETYLCHOLINE RECEPTOR
total genus 47
structure length 205
sequence length 205
chains with identical sequence B, C, D, E, F, G, H, I, J
ec nomenclature
pdb deposition date 2010-08-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02931 Neur_chan_LBD Neurotransmitter-gated ion-channel ligand binding domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.170.10 Mainly Beta Distorted Sandwich Acetylcholine Binding Protein; Chain: A, Neurotransmitter-gated ion-channel ligand-binding domain 2xntA00
3U8MA 4HFDA 2YMEA 3PEOA 4HFEA 4PIRA 4BFQA 4LMKA 3U8NA 3UUBA 4TWDA 2BG9A 4HFHA 2WNJA 5L4HA 4QH5A 5SYOA 3UQ4A 4EZ1A 4UM3P 4QH1A 4TNWA 2XQ4A 3TLUA 4FRRA 3SQ9A 2X00D 2XQ7A 4TWFA 3WTNA 4ALXA 3T4MA 5L47A 4ZZBA 4Z91A 3C84A 3TLVA 3UU4A 2PH9A 4TNVA 4DBMA 4B5DA 3EI0A 4IL4A 3RI5A 4COFA 2BG9E 4TWHA 2Y54A 3WIPA 5BW2A 3WTLA 5HEGA 5CFBA 2C9TA 5FJVA 3WTIA 3U8JA 2WNLA 5J5FA 5J5IA 5J0ZA 2Y58A 4UY2A 2WZYA 3SIOA 5CO5A 4QAAA 2BYNA 1UW6A 2YOEA 4ZRUA 2BYQA 4ZZCA 4QH4A 4A97A 2XQ9A 2XZ6A 5J5HA 2YKSA 3UU8A 4ILBA 4QACA 2Y57A 2VL0A 3RHWA 4AFTA 2X00A 2YN6A 2XZ5A 4X5TA 4QABA 5LXBA 3IGQA 3UU3A 3WTHA 3P4WA 4IL9A 5J5GA 2YMDA 4NZBA 3TLWA 3GUAA 4HFBA 5HCMA 3RIAA 5AFHA 1UV6A 5AINA 5L4EA 3C79A 3TLSA 5AFNA 3P50A 4UXUA 5HCJA 2XYSA 3RQUA 4UM3A 5AFJA 3EAMA 3UU6A 5KZUA 5AFLA 2WN9A 2BYRA 5JMEA 4XK9A 4ZR6A 4Z90A 5IUXA 3WTMA 3JAFA 4NPPA 5BP0A 3UU5A 3JADA 2ZJVA 2XNVA 3WTKA 2BYSA 4UM3S 4IREA 4WV9A 3WTJA 4D01A 2XNUA 3SQ6A 4AFHA 2XQ8A 4HFCA 4ILCA 3U8LA 5HEJA 5AFKA 3WTOA 4BQTA 4F8HA 5LG3A 2XQ5A 1I9BA 4ILAA 2UZ6A 2XQAA 3LSVA 2W8FA 2QC1B 3TLTA 3U8KA 4HQPA 3RIFA 2BG9B 2XYTA 2PGZA 5KE4A 3UQ7A 5BRXA 1UX2A 5HEOA 4ZK4A 3ZDHA 3EHZA 3JAEA 3ZKRA 2BYPA 2BJ0A 3ZDGA 2XQ6A 2Y7YA 4LMJA 2XQ3A 2BR8A 4ZK1A 3RQWA 5AFMA 2BR7A 4AFGA 2XNTA 5HEHA 2W8GA 4HFIA 4UM1A 5HEUA 5AFMB 5TVCA 3SH1A 4LMLA 4ZJTA 3PMZA 4XHEA 2BG9C 2Y56A 2ZJUA 4A98A 2WNCA 4ZJSA
chains in the Genus database with same CATH superfamily
3U8MA 4HFDA 2YMEA 3PEOA 4HFEA 4PIRA 4BFQA 4LMKA 3U8NA 3UUBA 4TWDA 2BG9A 4HFHA 2WNJA 5L4HA 4QH5A 5SYOA 3UQ4A 4EZ1A 4UM3P 4QH1A 4TNWA 2XQ4A 3TLUA 4FRRA 3SQ9A 2X00D 2XQ7A 4TWFA 3WTNA 4ALXA 3T4MA 5L47A 4ZZBA 4Z91A 3C84A 3TLVA 3UU4A 2PH9A 4TNVA 4DBMA 4B5DA 3EI0A 4IL4A 3RI5A 4COFA 2BG9E 4TWHA 2Y54A 3WIPA 5BW2A 3WTLA 5HEGA 5CFBA 2C9TA 5FJVA 3WTIA 3U8JA 2WNLA 5J5FA 5J5IA 5J0ZA 2Y58A 4UY2A 2WZYA 3SIOA 5CO5A 4QAAA 2BYNA 1UW6A 2YOEA 4ZRUA 2BYQA 4ZZCA 4QH4A 4A97A 2XQ9A 2XZ6A 5J5HA 2YKSA 3UU8A 4ILBA 4QACA 2Y57A 2VL0A 3RHWA 4AFTA 2X00A 2YN6A 2XZ5A 4X5TA 4QABA 5LXBA 3IGQA 3UU3A 3WTHA 3P4WA 4IL9A 5J5GA 2YMDA 4NZBA 3TLWA 3GUAA 4HFBA 5HCMA 3RIAA 5AFHA 1UV6A 5AINA 5L4EA 3C79A 3TLSA 5AFNA 3P50A 4UXUA 5HCJA 2XYSA 3RQUA 4UM3A 5AFJA 3EAMA 3UU6A 5KZUA 5AFLA 2WN9A 2BYRA 5JMEA 4XK9A 4ZR6A 4Z90A 5IUXA 3WTMA 3JAFA 4NPPA 5BP0A 3UU5A 3JADA 2ZJVA 2XNVA 3WTKA 2BYSA 4UM3S 4IREA 4WV9A 3WTJA 4D01A 2XNUA 3SQ6A 4AFHA 2XQ8A 4HFCA 4ILCA 3U8LA 5HEJA 5AFKA 3WTOA 4BQTA 4F8HA 5LG3A 2XQ5A 1I9BA 4ILAA 2UZ6A 2XQAA 3LSVA 2W8FA 2QC1B 3TLTA 3U8KA 4HQPA 3RIFA 2BG9B 2XYTA 2PGZA 5KE4A 3UQ7A 5BRXA 1UX2A 5HEOA 4ZK4A 3ZDHA 3EHZA 3JAEA 3ZKRA 2BYPA 2BJ0A 3ZDGA 2XQ6A 2Y7YA 4LMJA 2XQ3A 2BR8A 4ZK1A 3RQWA 5AFMA 2BR7A 4AFGA 2XNTA 5HEHA 2W8GA 4HFIA 4UM1A 5HEUA 5AFMB 5TVCA 3SH1A 4LMLA 4ZJTA 3PMZA 4XHEA 2BG9C 2Y56A 2ZJUA 4A98A 2WNCA 4ZJSA
chains in the Genus database with same CATH topology
3U8MA 4HFDA 2YMEA 3PEOA 4HFEA 4PIRA 4BFQA 4LMKA 3U8NA 3UUBA 4TWDA 2BG9A 4HFHA 2WNJA 5L4HA 4QH5A 5SYOA 3UQ4A 4EZ1A 4UM3P 4QH1A 4TNWA 2XQ4A 3TLUA 4FRRA 3SQ9A 2X00D 2XQ7A 4TWFA 3WTNA 4ALXA 3T4MA 5L47A 4ZZBA 4Z91A 3C84A 3TLVA 3UU4A 2PH9A 4TNVA 4DBMA 4B5DA 3EI0A 4IL4A 3RI5A 4COFA 2BG9E 4TWHA 2Y54A 3WIPA 5BW2A 3WTLA 5HEGA 5CFBA 2C9TA 5FJVA 3WTIA 3U8JA 2WNLA 5J5FA 5J5IA 5J0ZA 2Y58A 4UY2A 2WZYA 3SIOA 5CO5A 4QAAA 2BYNA 1UW6A 2YOEA 4ZRUA 2BYQA 4ZZCA 4QH4A 4A97A 2XQ9A 2XZ6A 5J5HA 2YKSA 3UU8A 4ILBA 4QACA 2Y57A 2VL0A 3RHWA 4AFTA 2X00A 2YN6A 2XZ5A 4X5TA 4QABA 5LXBA 3IGQA 3UU3A 3WTHA 3P4WA 4IL9A 5J5GA 2YMDA 4NZBA 3TLWA 3GUAA 4HFBA 5HCMA 3RIAA 5AFHA 1UV6A 5AINA 5L4EA 3C79A 3TLSA 5AFNA 3P50A 4UXUA 5HCJA 2XYSA 3RQUA 4UM3A 5AFJA 3EAMA 3UU6A 5KZUA 5AFLA 2WN9A 2BYRA 5JMEA 4XK9A 4ZR6A 4Z90A 5IUXA 3WTMA 3JAFA 4NPPA 5BP0A 3UU5A 3JADA 2ZJVA 2XNVA 3WTKA 2BYSA 4UM3S 4IREA 4WV9A 3WTJA 4D01A 2XNUA 3SQ6A 4AFHA 2XQ8A 4HFCA 4ILCA 3U8LA 5HEJA 5AFKA 3WTOA 4BQTA 4F8HA 5LG3A 2XQ5A 1I9BA 4ILAA 2UZ6A 2XQAA 3LSVA 2W8FA 2QC1B 3TLTA 3U8KA 4HQPA 3RIFA 2BG9B 2XYTA 2PGZA 5KE4A 3UQ7A 5BRXA 1UX2A 5HEOA 4ZK4A 3ZDHA 3EHZA 3JAEA 3ZKRA 2BYPA 2BJ0A 3ZDGA 2XQ6A 2Y7YA 4LMJA 2XQ3A 2BR8A 4ZK1A 3RQWA 5AFMA 2BR7A 4AFGA 2XNTA 5HEHA 2W8GA 4HFIA 4UM1A 5HEUA 5AFMB 5TVCA 3SH1A 4LMLA 4ZJTA 3PMZA 4XHEA 2BG9C 2Y56A 2ZJUA 4A98A 2WNCA 4ZJSA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3U8M A;  4HFD A;  2YME A;  3PEO A;  4HFE A;  4PIR A;  4BFQ A;  4LMK A;  3U8N A;  3UUB A;  4TWD A;  2BG9 A;  4HFH A;  2WNJ A;  5L4H A;  4QH5 A;  5SYO A;  3UQ4 A;  4EZ1 A;  4UM3 P;  4QH1 A;  4TNW A;  2XQ4 A;  3TLU A;  4FRR A;  3SQ9 A;  2X00 D;  2XQ7 A;  4TWF A;  3WTN A;  4ALX A;  3T4M A;  5L47 A;  4ZZB A;  4Z91 A;  3C84 A;  3TLV A;  3UU4 A;  2PH9 A;  4TNV A;  4DBM A;  4B5D A;  3EI0 A;  4IL4 A;  3RI5 A;  4COF A;  2BG9 E;  4TWH A;  2Y54 A;  3WIP A;  5BW2 A;  3WTL A;  5HEG A;  5CFB A;  2C9T A;  5FJV A;  3WTI A;  3U8J A;  2WNL A;  5J5F A;  5J5I A;  5J0Z A;  2Y58 A;  4UY2 A;  2WZY A;  3SIO A;  5CO5 A;  4QAA A;  2BYN A;  1UW6 A;  2YOE A;  4ZRU A;  2BYQ A;  4ZZC A;  4QH4 A;  4A97 A;  2XQ9 A;  2XZ6 A;  5J5H A;  2YKS A;  3UU8 A;  4ILB A;  4QAC A;  2Y57 A;  2VL0 A;  3RHW A;  4AFT A;  2X00 A;  2YN6 A;  2XZ5 A;  4X5T A;  4QAB A;  5LXB A;  3IGQ A;  3UU3 A;  3WTH A;  3P4W A;  4IL9 A;  5J5G A;  2YMD A;  4NZB A;  3TLW A;  3GUA A;  4HFB A;  5HCM A;  3RIA A;  5AFH A;  1UV6 A;  5AIN A;  5L4E A;  3C79 A;  3TLS A;  5AFN A;  3P50 A;  4UXU A;  5HCJ A;  2XYS A;  3RQU A;  4UM3 A;  5AFJ A;  3EAM A;  3UU6 A;  5KZU A;  5AFL A;  2WN9 A;  2BYR A;  5JME A;  4XK9 A;  4ZR6 A;  4Z90 A;  5IUX A;  3WTM A;  3JAF A;  4NPP A;  5BP0 A;  3UU5 A;  3JAD A;  2ZJV A;  2XNV A;  3WTK A;  2BYS A;  4UM3 S;  4IRE A;  4WV9 A;  3WTJ A;  4D01 A;  2XNU A;  3SQ6 A;  4AFH A;  2XQ8 A;  4HFC A;  4ILC A;  3U8L A;  5HEJ A;  5AFK A;  3WTO A;  4BQT A;  4F8H A;  5LG3 A;  2XQ5 A;  1I9B A;  4ILA A;  2UZ6 A;  2XQA A;  3LSV A;  2W8F A;  2QC1 B;  3TLT A;  3U8K A;  4HQP A;  3RIF A;  2BG9 B;  2XYT A;  2PGZ A;  5KE4 A;  3UQ7 A;  5BRX A;  1UX2 A;  5HEO A;  4ZK4 A;  3ZDH A;  3EHZ A;  3JAE A;  3ZKR A;  2BYP A;  2BJ0 A;  3ZDG A;  2XQ6 A;  2Y7Y A;  4LMJ A;  2XQ3 A;  2BR8 A;  4ZK1 A;  3RQW A;  5AFM A;  2BR7 A;  4AFG A;  2XNT A;  5HEH A;  2W8G A;  4HFI A;  4UM1 A;  5HEU A;  5AFM B;  5TVC A;  3SH1 A;  4LML A;  4ZJT A;  3PMZ A;  4XHE A;  2BG9 C;  2Y56 A;  2ZJU A;  4A98 A;  2WNC A;  4ZJS A; 
#chains in the Genus database with same CATH topology
 3U8M A;  4HFD A;  2YME A;  3PEO A;  4HFE A;  4PIR A;  4BFQ A;  4LMK A;  3U8N A;  3UUB A;  4TWD A;  2BG9 A;  4HFH A;  2WNJ A;  5L4H A;  4QH5 A;  5SYO A;  3UQ4 A;  4EZ1 A;  4UM3 P;  4QH1 A;  4TNW A;  2XQ4 A;  3TLU A;  4FRR A;  3SQ9 A;  2X00 D;  2XQ7 A;  4TWF A;  3WTN A;  4ALX A;  3T4M A;  5L47 A;  4ZZB A;  4Z91 A;  3C84 A;  3TLV A;  3UU4 A;  2PH9 A;  4TNV A;  4DBM A;  4B5D A;  3EI0 A;  4IL4 A;  3RI5 A;  4COF A;  2BG9 E;  4TWH A;  2Y54 A;  3WIP A;  5BW2 A;  3WTL A;  5HEG A;  5CFB A;  2C9T A;  5FJV A;  3WTI A;  3U8J A;  2WNL A;  5J5F A;  5J5I A;  5J0Z A;  2Y58 A;  4UY2 A;  2WZY A;  3SIO A;  5CO5 A;  4QAA A;  2BYN A;  1UW6 A;  2YOE A;  4ZRU A;  2BYQ A;  4ZZC A;  4QH4 A;  4A97 A;  2XQ9 A;  2XZ6 A;  5J5H A;  2YKS A;  3UU8 A;  4ILB A;  4QAC A;  2Y57 A;  2VL0 A;  3RHW A;  4AFT A;  2X00 A;  2YN6 A;  2XZ5 A;  4X5T A;  4QAB A;  5LXB A;  3IGQ A;  3UU3 A;  3WTH A;  3P4W A;  4IL9 A;  5J5G A;  2YMD A;  4NZB A;  3TLW A;  3GUA A;  4HFB A;  5HCM A;  3RIA A;  5AFH A;  1UV6 A;  5AIN A;  5L4E A;  3C79 A;  3TLS A;  5AFN A;  3P50 A;  4UXU A;  5HCJ A;  2XYS A;  3RQU A;  4UM3 A;  5AFJ A;  3EAM A;  3UU6 A;  5KZU A;  5AFL A;  2WN9 A;  2BYR A;  5JME A;  4XK9 A;  4ZR6 A;  4Z90 A;  5IUX A;  3WTM A;  3JAF A;  4NPP A;  5BP0 A;  3UU5 A;  3JAD A;  2ZJV A;  2XNV A;  3WTK A;  2BYS A;  4UM3 S;  4IRE A;  4WV9 A;  3WTJ A;  4D01 A;  2XNU A;  3SQ6 A;  4AFH A;  2XQ8 A;  4HFC A;  4ILC A;  3U8L A;  5HEJ A;  5AFK A;  3WTO A;  4BQT A;  4F8H A;  5LG3 A;  2XQ5 A;  1I9B A;  4ILA A;  2UZ6 A;  2XQA A;  3LSV A;  2W8F A;  2QC1 B;  3TLT A;  3U8K A;  4HQP A;  3RIF A;  2BG9 B;  2XYT A;  2PGZ A;  5KE4 A;  3UQ7 A;  5BRX A;  1UX2 A;  5HEO A;  4ZK4 A;  3ZDH A;  3EHZ A;  3JAE A;  3ZKR A;  2BYP A;  2BJ0 A;  3ZDG A;  2XQ6 A;  2Y7Y A;  4LMJ A;  2XQ3 A;  2BR8 A;  4ZK1 A;  3RQW A;  5AFM A;  2BR7 A;  4AFG A;  2XNT A;  5HEH A;  2W8G A;  4HFI A;  4UM1 A;  5HEU A;  5AFM B;  5TVC A;  3SH1 A;  4LML A;  4ZJT A;  3PMZ A;  4XHE A;  2BG9 C;  2Y56 A;  2ZJU A;  4A98 A;  2WNC A;  4ZJS A; 
#chains in the Genus database with same CATH homology
 3U8M A;  4HFD A;  2YME A;  3PEO A;  4HFE A;  4PIR A;  4BFQ A;  4LMK A;  3U8N A;  3UUB A;  4TWD A;  2BG9 A;  4HFH A;  2WNJ A;  5L4H A;  4QH5 A;  5SYO A;  3UQ4 A;  4EZ1 A;  4UM3 P;  4QH1 A;  4TNW A;  2XQ4 A;  3TLU A;  4FRR A;  3SQ9 A;  2X00 D;  2XQ7 A;  4TWF A;  3WTN A;  4ALX A;  3T4M A;  5L47 A;  4ZZB A;  4Z91 A;  3C84 A;  3TLV A;  3UU4 A;  2PH9 A;  4TNV A;  4DBM A;  4B5D A;  3EI0 A;  4IL4 A;  3RI5 A;  4COF A;  2BG9 E;  4TWH A;  2Y54 A;  3WIP A;  5BW2 A;  3WTL A;  5HEG A;  5CFB A;  2C9T A;  5FJV A;  3WTI A;  3U8J A;  2WNL A;  5J5F A;  5J5I A;  5J0Z A;  2Y58 A;  4UY2 A;  2WZY A;  3SIO A;  5CO5 A;  4QAA A;  2BYN A;  1UW6 A;  2YOE A;  4ZRU A;  2BYQ A;  4ZZC A;  4QH4 A;  4A97 A;  2XQ9 A;  2XZ6 A;  5J5H A;  2YKS A;  3UU8 A;  4ILB A;  4QAC A;  2Y57 A;  2VL0 A;  3RHW A;  4AFT A;  2X00 A;  2YN6 A;  2XZ5 A;  4X5T A;  4QAB A;  5LXB A;  3IGQ A;  3UU3 A;  3WTH A;  3P4W A;  4IL9 A;  5J5G A;  2YMD A;  4NZB A;  3TLW A;  3GUA A;  4HFB A;  5HCM A;  3RIA A;  5AFH A;  1UV6 A;  5AIN A;  5L4E A;  3C79 A;  3TLS A;  5AFN A;  3P50 A;  4UXU A;  5HCJ A;  2XYS A;  3RQU A;  4UM3 A;  5AFJ A;  3EAM A;  3UU6 A;  5KZU A;  5AFL A;  2WN9 A;  2BYR A;  5JME A;  4XK9 A;  4ZR6 A;  4Z90 A;  5IUX A;  3WTM A;  3JAF A;  4NPP A;  5BP0 A;  3UU5 A;  3JAD A;  2ZJV A;  2XNV A;  3WTK A;  2BYS A;  4UM3 S;  4IRE A;  4WV9 A;  3WTJ A;  4D01 A;  2XNU A;  3SQ6 A;  4AFH A;  2XQ8 A;  4HFC A;  4ILC A;  3U8L A;  5HEJ A;  5AFK A;  3WTO A;  4BQT A;  4F8H A;  5LG3 A;  2XQ5 A;  1I9B A;  4ILA A;  2UZ6 A;  2XQA A;  3LSV A;  2W8F A;  2QC1 B;  3TLT A;  3U8K A;  4HQP A;  3RIF A;  2BG9 B;  2XYT A;  2PGZ A;  5KE4 A;  3UQ7 A;  5BRX A;  1UX2 A;  5HEO A;  4ZK4 A;  3ZDH A;  3EHZ A;  3JAE A;  3ZKR A;  2BYP A;  2BJ0 A;  3ZDG A;  2XQ6 A;  2Y7Y A;  4LMJ A;  2XQ3 A;  2BR8 A;  4ZK1 A;  3RQW A;  5AFM A;  2BR7 A;  4AFG A;  2XNT A;  5HEH A;  2W8G A;  4HFI A;  4UM1 A;  5HEU A;  5AFM B;  5TVC A;  3SH1 A;  4LML A;  4ZJT A;  3PMZ A;  4XHE A;  2BG9 C;  2Y56 A;  2ZJU A;  4A98 A;  2WNC A;  4ZJS A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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