2XNVA

Acetylcholine binding protein (achbp) as template for hierarchical in silico screening procedures to identify structurally novel ligands for the nicotinic receptors
Total Genus 48
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
48
sequence length
205
structure length
205
Chain Sequence
QANLMRLKSDLFNRSPMYPGPTKDDPLTVTLGFTLQDIVKVDSSTNEVDLVYYEQQRWKLNSLMWDPNEYGNITDFRTSAADIWTPDITAYSSTRPVQVLSPQIAVVTHDGSVMFIPAQRLSFMCDPTGVDSEEGVTCAVKFGSWVYSGFEIDLKTDTDQVDLSSYYASSKYEILSATQTRQVQHYSCCPEPYIDVNLVVKFRER
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Receptor
source organism Aplysia californica
publication title Acetylcholine Binding Protein (Achbp) as Template for Hierarchical in Silico Screening Procedures to Identify Structurally Novel Ligands for the Nicotinic Receptors.
pubmed doi rcsb
molecule keywords SOLUBLE ACETYLCHOLINE RECEPTOR
total genus 48
structure length 205
sequence length 205
chains with identical sequence B, C, D, E, F, G, H, I, J
ec nomenclature
pdb deposition date 2010-08-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02931 Neur_chan_LBD Neurotransmitter-gated ion-channel ligand binding domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.170.10 Mainly Beta Distorted Sandwich Acetylcholine Binding Protein; Chain: A, Neurotransmitter-gated ion-channel ligand-binding domain 2xnvA00
4PIRA 3GUAA 2XNUA 4HQPA 2XQ7A 4ILCA 3TLTA 5J5FA 4ILBA 2XZ5A 1I9BA 3UU3A 5BRXA 2WZYA 2XQ4A 4QH1A 5HCMA 3SQ6A 2XNVA 2YOEA 3LSVA 4TWHA 5J5GA 3TLWA 2YMDA 3T4MA 3WTIA 2BYPA 5L47A 3WTMA 3UU8A 3TLSA 2C9TA 2ZJUA 5BW2A 2Y57A 2WNJA 4EZ1A 3RHWA 2W8FA 4ZJSA 2YKSA 5LXBA 3WTLA 5AINA 2XQ5A 4UM1A 2BR8A 4XK9A 3WTNA 4ALXA 3RQWA 4UY2A 2BYRA 4NZBA 4ZZBA 4UXUA 3RIAA 5JMEA 3WTKA 3P4WA 2XQ8A 2XZ6A 2X00D 4ZRUA 2XQ9A 5HCJA 4HFBA 4AFHA 3WIPA 2UZ6A 2XNTA 4HFHA 2XYSA 4TNWA 4ZK4A 2YMEA 3UU5A 3TLVA 4LMKA 5IUXA 4COFA 2Y54A 3UU6A 4D01A 2BR7A 4FRRA 1UW6A 4HFEA 2ZJVA 2BG9C 5TVCA 2BYQA 4XHEA 2XYTA 2BJ0A 5HEUA 3UQ7A 5FJVA 5L4EA 3RQUA 4IL4A 5SYOA 3TLUA 4ZZCA 4AFGA 5AFLA 4HFDA 5LG3A 3UUBA 2XQ3A 4WV9A 4TWDA 5AFNA 5HEGA 5BP0A 5CO5A 5AFKA 3C79A 4LMLA 4TWFA 4DBMA 5CFBA 2WN9A 3ZDGA 4ZR6A 5J5IA 3PEOA 5HEOA 3SIOA 5L4HA 4QACA 3ZDHA 2XQ6A 5AFMB 2Y7YA 4A98A 4BFQA 1UX2A 4ZJTA 2BYSA 2XQAA 4ZK1A 2PGZA 1UV6A 3U8MA 4F8HA 2Y58A 4LMJA 4QH4A 3PMZA 3U8NA 2BG9B 4QH5A 5AFMA 4HFIA 2BYNA 3C84A 3JAFA 3JAEA 4TNVA 3ZKRA 2WNCA 3EI0A 4BQTA 4UM3S 4X5TA 5HEHA 3JADA 4QABA 5AFHA 3WTHA 2BG9A 5KZUA 2VL0A 5KE4A 3U8KA 2WNLA 3P50A 5HEJA 3EHZA 4QAAA 3WTJA 4HFCA 2BG9E 4UM3A 2W8GA 2YN6A 3EAMA 4UM3P 5AFJA 3RI5A 4NPPA 5J0ZA 3IGQA 3SH1A 3UU4A 3WTOA 2PH9A 2Y56A 4Z91A 3U8LA 3UQ4A 2QC1B 2X00A 4Z90A 5J5HA 4IL9A 4AFTA 4ILAA 3SQ9A 4B5DA 3U8JA 4IREA 4A97A 3RIFA
chains in the Genus database with same CATH superfamily
4PIRA 3GUAA 2XNUA 4HQPA 2XQ7A 4ILCA 3TLTA 5J5FA 4ILBA 2XZ5A 1I9BA 3UU3A 5BRXA 2WZYA 2XQ4A 4QH1A 5HCMA 3SQ6A 2XNVA 2YOEA 3LSVA 4TWHA 5J5GA 3TLWA 2YMDA 3T4MA 3WTIA 2BYPA 5L47A 3WTMA 3UU8A 3TLSA 2C9TA 2ZJUA 5BW2A 2Y57A 2WNJA 4EZ1A 3RHWA 2W8FA 4ZJSA 2YKSA 5LXBA 3WTLA 5AINA 2XQ5A 4UM1A 2BR8A 4XK9A 3WTNA 4ALXA 3RQWA 4UY2A 2BYRA 4NZBA 4ZZBA 4UXUA 3RIAA 5JMEA 3WTKA 3P4WA 2XQ8A 2XZ6A 2X00D 4ZRUA 2XQ9A 5HCJA 4HFBA 4AFHA 3WIPA 2UZ6A 2XNTA 4HFHA 2XYSA 4TNWA 4ZK4A 2YMEA 3UU5A 3TLVA 4LMKA 5IUXA 4COFA 2Y54A 3UU6A 4D01A 2BR7A 4FRRA 1UW6A 4HFEA 2ZJVA 2BG9C 5TVCA 2BYQA 4XHEA 2XYTA 2BJ0A 5HEUA 3UQ7A 5FJVA 5L4EA 3RQUA 4IL4A 5SYOA 3TLUA 4ZZCA 4AFGA 5AFLA 4HFDA 5LG3A 3UUBA 2XQ3A 4WV9A 4TWDA 5AFNA 5HEGA 5BP0A 5CO5A 5AFKA 3C79A 4LMLA 4TWFA 4DBMA 5CFBA 2WN9A 3ZDGA 4ZR6A 5J5IA 3PEOA 5HEOA 3SIOA 5L4HA 4QACA 3ZDHA 2XQ6A 5AFMB 2Y7YA 4A98A 4BFQA 1UX2A 4ZJTA 2BYSA 2XQAA 4ZK1A 2PGZA 1UV6A 3U8MA 4F8HA 2Y58A 4LMJA 4QH4A 3PMZA 3U8NA 2BG9B 4QH5A 5AFMA 4HFIA 2BYNA 3C84A 3JAFA 3JAEA 4TNVA 3ZKRA 2WNCA 3EI0A 4BQTA 4UM3S 4X5TA 5HEHA 3JADA 4QABA 5AFHA 3WTHA 2BG9A 5KZUA 2VL0A 5KE4A 3U8KA 2WNLA 3P50A 5HEJA 3EHZA 4QAAA 3WTJA 4HFCA 2BG9E 4UM3A 2W8GA 2YN6A 3EAMA 4UM3P 5AFJA 3RI5A 4NPPA 5J0ZA 3IGQA 3SH1A 3UU4A 3WTOA 2PH9A 2Y56A 4Z91A 3U8LA 3UQ4A 2QC1B 2X00A 4Z90A 5J5HA 4IL9A 4AFTA 4ILAA 3SQ9A 4B5DA 3U8JA 4IREA 4A97A 3RIFA
chains in the Genus database with same CATH topology
4PIRA 3GUAA 2XNUA 4HQPA 2XQ7A 4ILCA 3TLTA 5J5FA 4ILBA 2XZ5A 1I9BA 3UU3A 5BRXA 2WZYA 2XQ4A 4QH1A 5HCMA 3SQ6A 2XNVA 2YOEA 3LSVA 4TWHA 5J5GA 3TLWA 2YMDA 3T4MA 3WTIA 2BYPA 5L47A 3WTMA 3UU8A 3TLSA 2C9TA 2ZJUA 5BW2A 2Y57A 2WNJA 4EZ1A 3RHWA 2W8FA 4ZJSA 2YKSA 5LXBA 3WTLA 5AINA 2XQ5A 4UM1A 2BR8A 4XK9A 3WTNA 4ALXA 3RQWA 4UY2A 2BYRA 4NZBA 4ZZBA 4UXUA 3RIAA 5JMEA 3WTKA 3P4WA 2XQ8A 2XZ6A 2X00D 4ZRUA 2XQ9A 5HCJA 4HFBA 4AFHA 3WIPA 2UZ6A 2XNTA 4HFHA 2XYSA 4TNWA 4ZK4A 2YMEA 3UU5A 3TLVA 4LMKA 5IUXA 4COFA 2Y54A 3UU6A 4D01A 2BR7A 4FRRA 1UW6A 4HFEA 2ZJVA 2BG9C 5TVCA 2BYQA 4XHEA 2XYTA 2BJ0A 5HEUA 3UQ7A 5FJVA 5L4EA 3RQUA 4IL4A 5SYOA 3TLUA 4ZZCA 4AFGA 5AFLA 4HFDA 5LG3A 3UUBA 2XQ3A 4WV9A 4TWDA 5AFNA 5HEGA 5BP0A 5CO5A 5AFKA 3C79A 4LMLA 4TWFA 4DBMA 5CFBA 2WN9A 3ZDGA 4ZR6A 5J5IA 3PEOA 5HEOA 3SIOA 5L4HA 4QACA 3ZDHA 2XQ6A 5AFMB 2Y7YA 4A98A 4BFQA 1UX2A 4ZJTA 2BYSA 2XQAA 4ZK1A 2PGZA 1UV6A 3U8MA 4F8HA 2Y58A 4LMJA 4QH4A 3PMZA 3U8NA 2BG9B 4QH5A 5AFMA 4HFIA 2BYNA 3C84A 3JAFA 3JAEA 4TNVA 3ZKRA 2WNCA 3EI0A 4BQTA 4UM3S 4X5TA 5HEHA 3JADA 4QABA 5AFHA 3WTHA 2BG9A 5KZUA 2VL0A 5KE4A 3U8KA 2WNLA 3P50A 5HEJA 3EHZA 4QAAA 3WTJA 4HFCA 2BG9E 4UM3A 2W8GA 2YN6A 3EAMA 4UM3P 5AFJA 3RI5A 4NPPA 5J0ZA 3IGQA 3SH1A 3UU4A 3WTOA 2PH9A 2Y56A 4Z91A 3U8LA 3UQ4A 2QC1B 2X00A 4Z90A 5J5HA 4IL9A 4AFTA 4ILAA 3SQ9A 4B5DA 3U8JA 4IREA 4A97A 3RIFA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4PIR A;  3GUA A;  2XNU A;  4HQP A;  2XQ7 A;  4ILC A;  3TLT A;  5J5F A;  4ILB A;  2XZ5 A;  1I9B A;  3UU3 A;  5BRX A;  2WZY A;  2XQ4 A;  4QH1 A;  5HCM A;  3SQ6 A;  2XNV A;  2YOE A;  3LSV A;  4TWH A;  5J5G A;  3TLW A;  2YMD A;  3T4M A;  3WTI A;  2BYP A;  5L47 A;  3WTM A;  3UU8 A;  3TLS A;  2C9T A;  2ZJU A;  5BW2 A;  2Y57 A;  2WNJ A;  4EZ1 A;  3RHW A;  2W8F A;  4ZJS A;  2YKS A;  5LXB A;  3WTL A;  5AIN A;  2XQ5 A;  4UM1 A;  2BR8 A;  4XK9 A;  3WTN A;  4ALX A;  3RQW A;  4UY2 A;  2BYR A;  4NZB A;  4ZZB A;  4UXU A;  3RIA A;  5JME A;  3WTK A;  3P4W A;  2XQ8 A;  2XZ6 A;  2X00 D;  4ZRU A;  2XQ9 A;  5HCJ A;  4HFB A;  4AFH A;  3WIP A;  2UZ6 A;  2XNT A;  4HFH A;  2XYS A;  4TNW A;  4ZK4 A;  2YME A;  3UU5 A;  3TLV A;  4LMK A;  5IUX A;  4COF A;  2Y54 A;  3UU6 A;  4D01 A;  2BR7 A;  4FRR A;  1UW6 A;  4HFE A;  2ZJV A;  2BG9 C;  5TVC A;  2BYQ A;  4XHE A;  2XYT A;  2BJ0 A;  5HEU A;  3UQ7 A;  5FJV A;  5L4E A;  3RQU A;  4IL4 A;  5SYO A;  3TLU A;  4ZZC A;  4AFG A;  5AFL A;  4HFD A;  5LG3 A;  3UUB A;  2XQ3 A;  4WV9 A;  4TWD A;  5AFN A;  5HEG A;  5BP0 A;  5CO5 A;  5AFK A;  3C79 A;  4LML A;  4TWF A;  4DBM A;  5CFB A;  2WN9 A;  3ZDG A;  4ZR6 A;  5J5I A;  3PEO A;  5HEO A;  3SIO A;  5L4H A;  4QAC A;  3ZDH A;  2XQ6 A;  5AFM B;  2Y7Y A;  4A98 A;  4BFQ A;  1UX2 A;  4ZJT A;  2BYS A;  2XQA A;  4ZK1 A;  2PGZ A;  1UV6 A;  3U8M A;  4F8H A;  2Y58 A;  4LMJ A;  4QH4 A;  3PMZ A;  3U8N A;  2BG9 B;  4QH5 A;  5AFM A;  4HFI A;  2BYN A;  3C84 A;  3JAF A;  3JAE A;  4TNV A;  3ZKR A;  2WNC A;  3EI0 A;  4BQT A;  4UM3 S;  4X5T A;  5HEH A;  3JAD A;  4QAB A;  5AFH A;  3WTH A;  2BG9 A;  5KZU A;  2VL0 A;  5KE4 A;  3U8K A;  2WNL A;  3P50 A;  5HEJ A;  3EHZ A;  4QAA A;  3WTJ A;  4HFC A;  2BG9 E;  4UM3 A;  2W8G A;  2YN6 A;  3EAM A;  4UM3 P;  5AFJ A;  3RI5 A;  4NPP A;  5J0Z A;  3IGQ A;  3SH1 A;  3UU4 A;  3WTO A;  2PH9 A;  2Y56 A;  4Z91 A;  3U8L A;  3UQ4 A;  2QC1 B;  2X00 A;  4Z90 A;  5J5H A;  4IL9 A;  4AFT A;  4ILA A;  3SQ9 A;  4B5D A;  3U8J A;  4IRE A;  4A97 A;  3RIF A; 
#chains in the Genus database with same CATH topology
 4PIR A;  3GUA A;  2XNU A;  4HQP A;  2XQ7 A;  4ILC A;  3TLT A;  5J5F A;  4ILB A;  2XZ5 A;  1I9B A;  3UU3 A;  5BRX A;  2WZY A;  2XQ4 A;  4QH1 A;  5HCM A;  3SQ6 A;  2XNV A;  2YOE A;  3LSV A;  4TWH A;  5J5G A;  3TLW A;  2YMD A;  3T4M A;  3WTI A;  2BYP A;  5L47 A;  3WTM A;  3UU8 A;  3TLS A;  2C9T A;  2ZJU A;  5BW2 A;  2Y57 A;  2WNJ A;  4EZ1 A;  3RHW A;  2W8F A;  4ZJS A;  2YKS A;  5LXB A;  3WTL A;  5AIN A;  2XQ5 A;  4UM1 A;  2BR8 A;  4XK9 A;  3WTN A;  4ALX A;  3RQW A;  4UY2 A;  2BYR A;  4NZB A;  4ZZB A;  4UXU A;  3RIA A;  5JME A;  3WTK A;  3P4W A;  2XQ8 A;  2XZ6 A;  2X00 D;  4ZRU A;  2XQ9 A;  5HCJ A;  4HFB A;  4AFH A;  3WIP A;  2UZ6 A;  2XNT A;  4HFH A;  2XYS A;  4TNW A;  4ZK4 A;  2YME A;  3UU5 A;  3TLV A;  4LMK A;  5IUX A;  4COF A;  2Y54 A;  3UU6 A;  4D01 A;  2BR7 A;  4FRR A;  1UW6 A;  4HFE A;  2ZJV A;  2BG9 C;  5TVC A;  2BYQ A;  4XHE A;  2XYT A;  2BJ0 A;  5HEU A;  3UQ7 A;  5FJV A;  5L4E A;  3RQU A;  4IL4 A;  5SYO A;  3TLU A;  4ZZC A;  4AFG A;  5AFL A;  4HFD A;  5LG3 A;  3UUB A;  2XQ3 A;  4WV9 A;  4TWD A;  5AFN A;  5HEG A;  5BP0 A;  5CO5 A;  5AFK A;  3C79 A;  4LML A;  4TWF A;  4DBM A;  5CFB A;  2WN9 A;  3ZDG A;  4ZR6 A;  5J5I A;  3PEO A;  5HEO A;  3SIO A;  5L4H A;  4QAC A;  3ZDH A;  2XQ6 A;  5AFM B;  2Y7Y A;  4A98 A;  4BFQ A;  1UX2 A;  4ZJT A;  2BYS A;  2XQA A;  4ZK1 A;  2PGZ A;  1UV6 A;  3U8M A;  4F8H A;  2Y58 A;  4LMJ A;  4QH4 A;  3PMZ A;  3U8N A;  2BG9 B;  4QH5 A;  5AFM A;  4HFI A;  2BYN A;  3C84 A;  3JAF A;  3JAE A;  4TNV A;  3ZKR A;  2WNC A;  3EI0 A;  4BQT A;  4UM3 S;  4X5T A;  5HEH A;  3JAD A;  4QAB A;  5AFH A;  3WTH A;  2BG9 A;  5KZU A;  2VL0 A;  5KE4 A;  3U8K A;  2WNL A;  3P50 A;  5HEJ A;  3EHZ A;  4QAA A;  3WTJ A;  4HFC A;  2BG9 E;  4UM3 A;  2W8G A;  2YN6 A;  3EAM A;  4UM3 P;  5AFJ A;  3RI5 A;  4NPP A;  5J0Z A;  3IGQ A;  3SH1 A;  3UU4 A;  3WTO A;  2PH9 A;  2Y56 A;  4Z91 A;  3U8L A;  3UQ4 A;  2QC1 B;  2X00 A;  4Z90 A;  5J5H A;  4IL9 A;  4AFT A;  4ILA A;  3SQ9 A;  4B5D A;  3U8J A;  4IRE A;  4A97 A;  3RIF A; 
#chains in the Genus database with same CATH homology
 4PIR A;  3GUA A;  2XNU A;  4HQP A;  2XQ7 A;  4ILC A;  3TLT A;  5J5F A;  4ILB A;  2XZ5 A;  1I9B A;  3UU3 A;  5BRX A;  2WZY A;  2XQ4 A;  4QH1 A;  5HCM A;  3SQ6 A;  2XNV A;  2YOE A;  3LSV A;  4TWH A;  5J5G A;  3TLW A;  2YMD A;  3T4M A;  3WTI A;  2BYP A;  5L47 A;  3WTM A;  3UU8 A;  3TLS A;  2C9T A;  2ZJU A;  5BW2 A;  2Y57 A;  2WNJ A;  4EZ1 A;  3RHW A;  2W8F A;  4ZJS A;  2YKS A;  5LXB A;  3WTL A;  5AIN A;  2XQ5 A;  4UM1 A;  2BR8 A;  4XK9 A;  3WTN A;  4ALX A;  3RQW A;  4UY2 A;  2BYR A;  4NZB A;  4ZZB A;  4UXU A;  3RIA A;  5JME A;  3WTK A;  3P4W A;  2XQ8 A;  2XZ6 A;  2X00 D;  4ZRU A;  2XQ9 A;  5HCJ A;  4HFB A;  4AFH A;  3WIP A;  2UZ6 A;  2XNT A;  4HFH A;  2XYS A;  4TNW A;  4ZK4 A;  2YME A;  3UU5 A;  3TLV A;  4LMK A;  5IUX A;  4COF A;  2Y54 A;  3UU6 A;  4D01 A;  2BR7 A;  4FRR A;  1UW6 A;  4HFE A;  2ZJV A;  2BG9 C;  5TVC A;  2BYQ A;  4XHE A;  2XYT A;  2BJ0 A;  5HEU A;  3UQ7 A;  5FJV A;  5L4E A;  3RQU A;  4IL4 A;  5SYO A;  3TLU A;  4ZZC A;  4AFG A;  5AFL A;  4HFD A;  5LG3 A;  3UUB A;  2XQ3 A;  4WV9 A;  4TWD A;  5AFN A;  5HEG A;  5BP0 A;  5CO5 A;  5AFK A;  3C79 A;  4LML A;  4TWF A;  4DBM A;  5CFB A;  2WN9 A;  3ZDG A;  4ZR6 A;  5J5I A;  3PEO A;  5HEO A;  3SIO A;  5L4H A;  4QAC A;  3ZDH A;  2XQ6 A;  5AFM B;  2Y7Y A;  4A98 A;  4BFQ A;  1UX2 A;  4ZJT A;  2BYS A;  2XQA A;  4ZK1 A;  2PGZ A;  1UV6 A;  3U8M A;  4F8H A;  2Y58 A;  4LMJ A;  4QH4 A;  3PMZ A;  3U8N A;  2BG9 B;  4QH5 A;  5AFM A;  4HFI A;  2BYN A;  3C84 A;  3JAF A;  3JAE A;  4TNV A;  3ZKR A;  2WNC A;  3EI0 A;  4BQT A;  4UM3 S;  4X5T A;  5HEH A;  3JAD A;  4QAB A;  5AFH A;  3WTH A;  2BG9 A;  5KZU A;  2VL0 A;  5KE4 A;  3U8K A;  2WNL A;  3P50 A;  5HEJ A;  3EHZ A;  4QAA A;  3WTJ A;  4HFC A;  2BG9 E;  4UM3 A;  2W8G A;  2YN6 A;  3EAM A;  4UM3 P;  5AFJ A;  3RI5 A;  4NPP A;  5J0Z A;  3IGQ A;  3SH1 A;  3UU4 A;  3WTO A;  2PH9 A;  2Y56 A;  4Z91 A;  3U8L A;  3UQ4 A;  2QC1 B;  2X00 A;  4Z90 A;  5J5H A;  4IL9 A;  4AFT A;  4ILA A;  3SQ9 A;  4B5D A;  3U8J A;  4IRE A;  4A97 A;  3RIF A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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