2XNVA

Acetylcholine binding protein (achbp) as template for hierarchical in silico screening procedures to identify structurally novel ligands for the nicotinic receptors
Total Genus 48

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
48
sequence length
205
structure length
205
Chain Sequence
QANLMRLKSDLFNRSPMYPGPTKDDPLTVTLGFTLQDIVKVDSSTNEVDLVYYEQQRWKLNSLMWDPNEYGNITDFRTSAADIWTPDITAYSSTRPVQVLSPQIAVVTHDGSVMFIPAQRLSFMCDPTGVDSEEGVTCAVKFGSWVYSGFEIDLKTDTDQVDLSSYYASSKYEILSATQTRQVQHYSCCPEPYIDVNLVVKFRER

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
3H2 (67-69)AH1 (1-13)S3 (75-79)TIV2 (70-73)TI1 (22-25)S1 (27-42)TI8 (148-151)S11 (172-186)TI2 (42-45)TI3 (43-46)S2 (47-59)O1 (125-138)S5 (93-99)EMPTYTIV5 (156-159)TI4 (108-111)S4 (88-90)S9 (136-144)S8 (118-124)TIV3 (90-93)S6 (104-108)S7 (112-115)TII1 (127-130)TI5 (129-132)S12 (189-204)TI6 (132-135)TI7 (144-147)S10 (152-156)TI9 (163-166)TI10 (167-170)TVIII2 (170-173)3H1 (61-63)3H3 (80-82)Updating...
connected with : NaN
molecule tags Receptor
source organism Aplysia californica
publication title Acetylcholine Binding Protein (Achbp) as Template for Hierarchical in Silico Screening Procedures to Identify Structurally Novel Ligands for the Nicotinic Receptors.
pubmed doi rcsb
molecule keywords SOLUBLE ACETYLCHOLINE RECEPTOR
total genus 48
structure length 205
sequence length 205
chains with identical sequence B, C, D, E, F, G, H, I, J
ec nomenclature
pdb deposition date 2010-08-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02931 Neur_chan_LBD Neurotransmitter-gated ion-channel ligand binding domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.170.10 Mainly Beta Distorted Sandwich Acetylcholine Binding Protein; Chain: A, Neurotransmitter-gated ion-channel ligand-binding domain 2xnvA00
2XQ8A 2YMDA 3U8LA 4EZ1A 4WV9A 5JMEA 4QABA 3TLWA 1UW6A 4BFQA 4TWHA 5HEOA 3UU5A 4UXUA 5HEHA 4ZZCA 4ALXA 5J5IA 2PGZA 3JAFA 2WZYA 4HFHA 4DBMA 2WNJA 3U8MA 4F8HA 5AFJA 2XZ5A 4HFCA 4COFA 5KZUA 4QACA 3RIAA 3ZDGA 2W8GA 2ZJUA 3U8JA 3EHZA 3SQ9A 2BG9E 4TNVA 4QH4A 2C9TA 2BG9C 4XK9A 5HEUA 4Z90A 3UUBA 2Y54A 4BQTA 5J5FA 5HCMA 3RI5A 3UU3A 5BW2A 3JAEA 3WTIA 3ZDHA 5BP0A 2XQ4A 2BYRA 2QC1B 4ZK1A 4B5DA 2BYPA 2X00A 2YKSA 2Y56A 3P50A 4QAAA 4ILBA 5TVCA 3LSVA 4ZZBA 2BG9A 3JADA 4UM3P 5L4HA 2XQ5A 3T4MA 4LMJA 3TLSA 4TWDA 3RQWA 5L47A 2BR8A 2YOEA 2XQ6A 5L4EA 4HFDA 3RHWA 4ZK4A 2UZ6A 3ZKRA 4AFHA 4NPPA 4LMLA 2BJ0A 4IL4A 5HCJA 5IUXA 2WNCA 4HFBA 3SIOA 3EAMA 3UQ7A 2XQAA 4A98A 2XQ7A 5J0ZA 3RIFA 4A97A 4UM1A 4ZRUA 5LG3A 3TLVA 5HEGA 3C79A 4ILAA 4UY2A 5CFBA 4LMKA 5AFHA 4D01A 4NZBA 2Y58A 5J5HA 3TLTA 2Y7YA 5LXBA 2XNUA 4TNWA 4ZJSA 4HFIA 3U8KA 3WTNA 5SYOA 4FRRA 3UU6A 3EI0A 3TLUA 3WTMA 5AFMB 2XZ6A 3WIPA 4QH5A 4AFTA 2WN9A 3P4WA 2Y57A 3UU8A 4X5TA 4AFGA 4UM3S 5HEJA 3U8NA 5AINA 4UM3A 3C84A 1UX2A 4ZJTA 5BRXA 3SH1A 3SQ6A 3UU4A 2BYNA 5KE4A 3WTKA 5AFLA 2XNVA 3IGQA 1I9BA 3PEOA 2XQ3A 2X00D 2PH9A 3GUAA 4Z91A 4XHEA 4ILCA 2BYQA 4TWFA 3PMZA 4QH1A 4IREA 2XYTA 2VL0A 2XYSA 4PIRA 4ZR6A 3WTJA 3UQ4A 3WTLA 2YN6A 1UV6A 4HFEA 2BYSA 5CO5A 5FJVA 3RQUA 2XQ9A 4HQPA 5J5GA 4IL9A 2BR7A 2W8FA 5AFMA 3WTHA 2XNTA 2ZJVA 3WTOA 5AFNA 5AFKA 2BG9B 2YMEA 2WNLA
chains in the Genus database with same CATH superfamily
2XQ8A 2YMDA 3U8LA 4EZ1A 4WV9A 5JMEA 4QABA 3TLWA 1UW6A 4BFQA 4TWHA 5HEOA 3UU5A 4UXUA 5HEHA 4ZZCA 4ALXA 5J5IA 2PGZA 3JAFA 2WZYA 4HFHA 4DBMA 2WNJA 3U8MA 4F8HA 5AFJA 2XZ5A 4HFCA 4COFA 5KZUA 4QACA 3RIAA 3ZDGA 2W8GA 2ZJUA 3U8JA 3EHZA 3SQ9A 2BG9E 4TNVA 4QH4A 2C9TA 2BG9C 4XK9A 5HEUA 4Z90A 3UUBA 2Y54A 4BQTA 5J5FA 5HCMA 3RI5A 3UU3A 5BW2A 3JAEA 3WTIA 3ZDHA 5BP0A 2XQ4A 2BYRA 2QC1B 4ZK1A 4B5DA 2BYPA 2X00A 2YKSA 2Y56A 3P50A 4QAAA 4ILBA 5TVCA 3LSVA 4ZZBA 2BG9A 3JADA 4UM3P 5L4HA 2XQ5A 3T4MA 4LMJA 3TLSA 4TWDA 3RQWA 5L47A 2BR8A 2YOEA 2XQ6A 5L4EA 4HFDA 3RHWA 4ZK4A 2UZ6A 3ZKRA 4AFHA 4NPPA 4LMLA 2BJ0A 4IL4A 5HCJA 5IUXA 2WNCA 4HFBA 3SIOA 3EAMA 3UQ7A 2XQAA 4A98A 2XQ7A 5J0ZA 3RIFA 4A97A 4UM1A 4ZRUA 5LG3A 3TLVA 5HEGA 3C79A 4ILAA 4UY2A 5CFBA 4LMKA 5AFHA 4D01A 4NZBA 2Y58A 5J5HA 3TLTA 2Y7YA 5LXBA 2XNUA 4TNWA 4ZJSA 4HFIA 3U8KA 3WTNA 5SYOA 4FRRA 3UU6A 3EI0A 3TLUA 3WTMA 5AFMB 2XZ6A 3WIPA 4QH5A 4AFTA 2WN9A 3P4WA 2Y57A 3UU8A 4X5TA 4AFGA 4UM3S 5HEJA 3U8NA 5AINA 4UM3A 3C84A 1UX2A 4ZJTA 5BRXA 3SH1A 3SQ6A 3UU4A 2BYNA 5KE4A 3WTKA 5AFLA 2XNVA 3IGQA 1I9BA 3PEOA 2XQ3A 2X00D 2PH9A 3GUAA 4Z91A 4XHEA 4ILCA 2BYQA 4TWFA 3PMZA 4QH1A 4IREA 2XYTA 2VL0A 2XYSA 4PIRA 4ZR6A 3WTJA 3UQ4A 3WTLA 2YN6A 1UV6A 4HFEA 2BYSA 5CO5A 5FJVA 3RQUA 2XQ9A 4HQPA 5J5GA 4IL9A 2BR7A 2W8FA 5AFMA 3WTHA 2XNTA 2ZJVA 3WTOA 5AFNA 5AFKA 2BG9B 2YMEA 2WNLA
chains in the Genus database with same CATH topology
2XQ8A 2YMDA 3U8LA 4EZ1A 4WV9A 5JMEA 4QABA 3TLWA 1UW6A 4BFQA 4TWHA 5HEOA 3UU5A 4UXUA 5HEHA 4ZZCA 4ALXA 5J5IA 2PGZA 3JAFA 2WZYA 4HFHA 4DBMA 2WNJA 3U8MA 4F8HA 5AFJA 2XZ5A 4HFCA 4COFA 5KZUA 4QACA 3RIAA 3ZDGA 2W8GA 2ZJUA 3U8JA 3EHZA 3SQ9A 2BG9E 4TNVA 4QH4A 2C9TA 2BG9C 4XK9A 5HEUA 4Z90A 3UUBA 2Y54A 4BQTA 5J5FA 5HCMA 3RI5A 3UU3A 5BW2A 3JAEA 3WTIA 3ZDHA 5BP0A 2XQ4A 2BYRA 2QC1B 4ZK1A 4B5DA 2BYPA 2X00A 2YKSA 2Y56A 3P50A 4QAAA 4ILBA 5TVCA 3LSVA 4ZZBA 2BG9A 3JADA 4UM3P 5L4HA 2XQ5A 3T4MA 4LMJA 3TLSA 4TWDA 3RQWA 5L47A 2BR8A 2YOEA 2XQ6A 5L4EA 4HFDA 3RHWA 4ZK4A 2UZ6A 3ZKRA 4AFHA 4NPPA 4LMLA 2BJ0A 4IL4A 5HCJA 5IUXA 2WNCA 4HFBA 3SIOA 3EAMA 3UQ7A 2XQAA 4A98A 2XQ7A 5J0ZA 3RIFA 4A97A 4UM1A 4ZRUA 5LG3A 3TLVA 5HEGA 3C79A 4ILAA 4UY2A 5CFBA 4LMKA 5AFHA 4D01A 4NZBA 2Y58A 5J5HA 3TLTA 2Y7YA 5LXBA 2XNUA 4TNWA 4ZJSA 4HFIA 3U8KA 3WTNA 5SYOA 4FRRA 3UU6A 3EI0A 3TLUA 3WTMA 5AFMB 2XZ6A 3WIPA 4QH5A 4AFTA 2WN9A 3P4WA 2Y57A 3UU8A 4X5TA 4AFGA 4UM3S 5HEJA 3U8NA 5AINA 4UM3A 3C84A 1UX2A 4ZJTA 5BRXA 3SH1A 3SQ6A 3UU4A 2BYNA 5KE4A 3WTKA 5AFLA 2XNVA 3IGQA 1I9BA 3PEOA 2XQ3A 2X00D 2PH9A 3GUAA 4Z91A 4XHEA 4ILCA 2BYQA 4TWFA 3PMZA 4QH1A 4IREA 2XYTA 2VL0A 2XYSA 4PIRA 4ZR6A 3WTJA 3UQ4A 3WTLA 2YN6A 1UV6A 4HFEA 2BYSA 5CO5A 5FJVA 3RQUA 2XQ9A 4HQPA 5J5GA 4IL9A 2BR7A 2W8FA 5AFMA 3WTHA 2XNTA 2ZJVA 3WTOA 5AFNA 5AFKA 2BG9B 2YMEA 2WNLA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2XQ8 A;  2YMD A;  3U8L A;  4EZ1 A;  4WV9 A;  5JME A;  4QAB A;  3TLW A;  1UW6 A;  4BFQ A;  4TWH A;  5HEO A;  3UU5 A;  4UXU A;  5HEH A;  4ZZC A;  4ALX A;  5J5I A;  2PGZ A;  3JAF A;  2WZY A;  4HFH A;  4DBM A;  2WNJ A;  3U8M A;  4F8H A;  5AFJ A;  2XZ5 A;  4HFC A;  4COF A;  5KZU A;  4QAC A;  3RIA A;  3ZDG A;  2W8G A;  2ZJU A;  3U8J A;  3EHZ A;  3SQ9 A;  2BG9 E;  4TNV A;  4QH4 A;  2C9T A;  2BG9 C;  4XK9 A;  5HEU A;  4Z90 A;  3UUB A;  2Y54 A;  4BQT A;  5J5F A;  5HCM A;  3RI5 A;  3UU3 A;  5BW2 A;  3JAE A;  3WTI A;  3ZDH A;  5BP0 A;  2XQ4 A;  2BYR A;  2QC1 B;  4ZK1 A;  4B5D A;  2BYP A;  2X00 A;  2YKS A;  2Y56 A;  3P50 A;  4QAA A;  4ILB A;  5TVC A;  3LSV A;  4ZZB A;  2BG9 A;  3JAD A;  4UM3 P;  5L4H A;  2XQ5 A;  3T4M A;  4LMJ A;  3TLS A;  4TWD A;  3RQW A;  5L47 A;  2BR8 A;  2YOE A;  2XQ6 A;  5L4E A;  4HFD A;  3RHW A;  4ZK4 A;  2UZ6 A;  3ZKR A;  4AFH A;  4NPP A;  4LML A;  2BJ0 A;  4IL4 A;  5HCJ A;  5IUX A;  2WNC A;  4HFB A;  3SIO A;  3EAM A;  3UQ7 A;  2XQA A;  4A98 A;  2XQ7 A;  5J0Z A;  3RIF A;  4A97 A;  4UM1 A;  4ZRU A;  5LG3 A;  3TLV A;  5HEG A;  3C79 A;  4ILA A;  4UY2 A;  5CFB A;  4LMK A;  5AFH A;  4D01 A;  4NZB A;  2Y58 A;  5J5H A;  3TLT A;  2Y7Y A;  5LXB A;  2XNU A;  4TNW A;  4ZJS A;  4HFI A;  3U8K A;  3WTN A;  5SYO A;  4FRR A;  3UU6 A;  3EI0 A;  3TLU A;  3WTM A;  5AFM B;  2XZ6 A;  3WIP A;  4QH5 A;  4AFT A;  2WN9 A;  3P4W A;  2Y57 A;  3UU8 A;  4X5T A;  4AFG A;  4UM3 S;  5HEJ A;  3U8N A;  5AIN A;  4UM3 A;  3C84 A;  1UX2 A;  4ZJT A;  5BRX A;  3SH1 A;  3SQ6 A;  3UU4 A;  2BYN A;  5KE4 A;  3WTK A;  5AFL A;  2XNV A;  3IGQ A;  1I9B A;  3PEO A;  2XQ3 A;  2X00 D;  2PH9 A;  3GUA A;  4Z91 A;  4XHE A;  4ILC A;  2BYQ A;  4TWF A;  3PMZ A;  4QH1 A;  4IRE A;  2XYT A;  2VL0 A;  2XYS A;  4PIR A;  4ZR6 A;  3WTJ A;  3UQ4 A;  3WTL A;  2YN6 A;  1UV6 A;  4HFE A;  2BYS A;  5CO5 A;  5FJV A;  3RQU A;  2XQ9 A;  4HQP A;  5J5G A;  4IL9 A;  2BR7 A;  2W8F A;  5AFM A;  3WTH A;  2XNT A;  2ZJV A;  3WTO A;  5AFN A;  5AFK A;  2BG9 B;  2YME A;  2WNL A; 
#chains in the Genus database with same CATH topology
 2XQ8 A;  2YMD A;  3U8L A;  4EZ1 A;  4WV9 A;  5JME A;  4QAB A;  3TLW A;  1UW6 A;  4BFQ A;  4TWH A;  5HEO A;  3UU5 A;  4UXU A;  5HEH A;  4ZZC A;  4ALX A;  5J5I A;  2PGZ A;  3JAF A;  2WZY A;  4HFH A;  4DBM A;  2WNJ A;  3U8M A;  4F8H A;  5AFJ A;  2XZ5 A;  4HFC A;  4COF A;  5KZU A;  4QAC A;  3RIA A;  3ZDG A;  2W8G A;  2ZJU A;  3U8J A;  3EHZ A;  3SQ9 A;  2BG9 E;  4TNV A;  4QH4 A;  2C9T A;  2BG9 C;  4XK9 A;  5HEU A;  4Z90 A;  3UUB A;  2Y54 A;  4BQT A;  5J5F A;  5HCM A;  3RI5 A;  3UU3 A;  5BW2 A;  3JAE A;  3WTI A;  3ZDH A;  5BP0 A;  2XQ4 A;  2BYR A;  2QC1 B;  4ZK1 A;  4B5D A;  2BYP A;  2X00 A;  2YKS A;  2Y56 A;  3P50 A;  4QAA A;  4ILB A;  5TVC A;  3LSV A;  4ZZB A;  2BG9 A;  3JAD A;  4UM3 P;  5L4H A;  2XQ5 A;  3T4M A;  4LMJ A;  3TLS A;  4TWD A;  3RQW A;  5L47 A;  2BR8 A;  2YOE A;  2XQ6 A;  5L4E A;  4HFD A;  3RHW A;  4ZK4 A;  2UZ6 A;  3ZKR A;  4AFH A;  4NPP A;  4LML A;  2BJ0 A;  4IL4 A;  5HCJ A;  5IUX A;  2WNC A;  4HFB A;  3SIO A;  3EAM A;  3UQ7 A;  2XQA A;  4A98 A;  2XQ7 A;  5J0Z A;  3RIF A;  4A97 A;  4UM1 A;  4ZRU A;  5LG3 A;  3TLV A;  5HEG A;  3C79 A;  4ILA A;  4UY2 A;  5CFB A;  4LMK A;  5AFH A;  4D01 A;  4NZB A;  2Y58 A;  5J5H A;  3TLT A;  2Y7Y A;  5LXB A;  2XNU A;  4TNW A;  4ZJS A;  4HFI A;  3U8K A;  3WTN A;  5SYO A;  4FRR A;  3UU6 A;  3EI0 A;  3TLU A;  3WTM A;  5AFM B;  2XZ6 A;  3WIP A;  4QH5 A;  4AFT A;  2WN9 A;  3P4W A;  2Y57 A;  3UU8 A;  4X5T A;  4AFG A;  4UM3 S;  5HEJ A;  3U8N A;  5AIN A;  4UM3 A;  3C84 A;  1UX2 A;  4ZJT A;  5BRX A;  3SH1 A;  3SQ6 A;  3UU4 A;  2BYN A;  5KE4 A;  3WTK A;  5AFL A;  2XNV A;  3IGQ A;  1I9B A;  3PEO A;  2XQ3 A;  2X00 D;  2PH9 A;  3GUA A;  4Z91 A;  4XHE A;  4ILC A;  2BYQ A;  4TWF A;  3PMZ A;  4QH1 A;  4IRE A;  2XYT A;  2VL0 A;  2XYS A;  4PIR A;  4ZR6 A;  3WTJ A;  3UQ4 A;  3WTL A;  2YN6 A;  1UV6 A;  4HFE A;  2BYS A;  5CO5 A;  5FJV A;  3RQU A;  2XQ9 A;  4HQP A;  5J5G A;  4IL9 A;  2BR7 A;  2W8F A;  5AFM A;  3WTH A;  2XNT A;  2ZJV A;  3WTO A;  5AFN A;  5AFK A;  2BG9 B;  2YME A;  2WNL A; 
#chains in the Genus database with same CATH homology
 2XQ8 A;  2YMD A;  3U8L A;  4EZ1 A;  4WV9 A;  5JME A;  4QAB A;  3TLW A;  1UW6 A;  4BFQ A;  4TWH A;  5HEO A;  3UU5 A;  4UXU A;  5HEH A;  4ZZC A;  4ALX A;  5J5I A;  2PGZ A;  3JAF A;  2WZY A;  4HFH A;  4DBM A;  2WNJ A;  3U8M A;  4F8H A;  5AFJ A;  2XZ5 A;  4HFC A;  4COF A;  5KZU A;  4QAC A;  3RIA A;  3ZDG A;  2W8G A;  2ZJU A;  3U8J A;  3EHZ A;  3SQ9 A;  2BG9 E;  4TNV A;  4QH4 A;  2C9T A;  2BG9 C;  4XK9 A;  5HEU A;  4Z90 A;  3UUB A;  2Y54 A;  4BQT A;  5J5F A;  5HCM A;  3RI5 A;  3UU3 A;  5BW2 A;  3JAE A;  3WTI A;  3ZDH A;  5BP0 A;  2XQ4 A;  2BYR A;  2QC1 B;  4ZK1 A;  4B5D A;  2BYP A;  2X00 A;  2YKS A;  2Y56 A;  3P50 A;  4QAA A;  4ILB A;  5TVC A;  3LSV A;  4ZZB A;  2BG9 A;  3JAD A;  4UM3 P;  5L4H A;  2XQ5 A;  3T4M A;  4LMJ A;  3TLS A;  4TWD A;  3RQW A;  5L47 A;  2BR8 A;  2YOE A;  2XQ6 A;  5L4E A;  4HFD A;  3RHW A;  4ZK4 A;  2UZ6 A;  3ZKR A;  4AFH A;  4NPP A;  4LML A;  2BJ0 A;  4IL4 A;  5HCJ A;  5IUX A;  2WNC A;  4HFB A;  3SIO A;  3EAM A;  3UQ7 A;  2XQA A;  4A98 A;  2XQ7 A;  5J0Z A;  3RIF A;  4A97 A;  4UM1 A;  4ZRU A;  5LG3 A;  3TLV A;  5HEG A;  3C79 A;  4ILA A;  4UY2 A;  5CFB A;  4LMK A;  5AFH A;  4D01 A;  4NZB A;  2Y58 A;  5J5H A;  3TLT A;  2Y7Y A;  5LXB A;  2XNU A;  4TNW A;  4ZJS A;  4HFI A;  3U8K A;  3WTN A;  5SYO A;  4FRR A;  3UU6 A;  3EI0 A;  3TLU A;  3WTM A;  5AFM B;  2XZ6 A;  3WIP A;  4QH5 A;  4AFT A;  2WN9 A;  3P4W A;  2Y57 A;  3UU8 A;  4X5T A;  4AFG A;  4UM3 S;  5HEJ A;  3U8N A;  5AIN A;  4UM3 A;  3C84 A;  1UX2 A;  4ZJT A;  5BRX A;  3SH1 A;  3SQ6 A;  3UU4 A;  2BYN A;  5KE4 A;  3WTK A;  5AFL A;  2XNV A;  3IGQ A;  1I9B A;  3PEO A;  2XQ3 A;  2X00 D;  2PH9 A;  3GUA A;  4Z91 A;  4XHE A;  4ILC A;  2BYQ A;  4TWF A;  3PMZ A;  4QH1 A;  4IRE A;  2XYT A;  2VL0 A;  2XYS A;  4PIR A;  4ZR6 A;  3WTJ A;  3UQ4 A;  3WTL A;  2YN6 A;  1UV6 A;  4HFE A;  2BYS A;  5CO5 A;  5FJV A;  3RQU A;  2XQ9 A;  4HQP A;  5J5G A;  4IL9 A;  2BR7 A;  2W8F A;  5AFM A;  3WTH A;  2XNT A;  2ZJV A;  3WTO A;  5AFN A;  5AFK A;  2BG9 B;  2YME A;  2WNL A; 
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similar chains in the Genus database (?% sequence similarity)
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