2Y57A

Fragment growing induces conformational changes in acetylcholine- binding protein: a structural and thermodynamic analysis - (compound 4)
Total Genus 44
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
44
sequence length
205
structure length
205
Chain Sequence
QANLMRLKSDLFNRSPMYPGPTKDDPLTVTLGFTLQDIVKVDSSTNEVDLVYYEQQRWKLNSLMWDPNEYGNITDFRTSAADIWTPDITAYSSTRPVQVLSPQIAVVTHDGSVMFIPAQRLSFMCDPTGVDSEEGVTCAVKFGSWVYSGFEIDLKTDTDQVDLSSYYASSKYEILSATQTRQVQHYSCCPEPYIDVNLVVKFRER
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Fragment Growing Induces Conformational Changes in Acetylcholine-Binding Protein: A Structural and Thermodynamic Analysis.
pubmed doi rcsb
molecule tags Receptor
source organism Aplysia californica
molecule keywords SOLUBLE ACETYLCHOLINE RECEPTOR
total genus 44
structure length 205
sequence length 205
chains with identical sequence B, C, D, E
ec nomenclature
pdb deposition date 2011-01-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02931 Neur_chan_LBD Neurotransmitter-gated ion-channel ligand binding domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.170.10 Mainly Beta Distorted Sandwich Acetylcholine Binding Protein; Chain: A, Neurotransmitter-gated ion-channel ligand-binding domain 2y57A00
3UU4A 3U8NA 2BYSA 3WTJA 3WTNA 4LMJA 2BYQA 5BP0A 2WN9A 2YN6A 2C9TA 4QABA 4TWHA 4ALXA 2BG9C 5J5HA 2XQ3A 3IGQA 2VL0A 4X5TA 5L47A 5AFMA 4HFDA 5BRXA 5L4EA 3PEOA 4WV9A 3ZDHA 3UU6A 3WTMA 3UU5A 5LG3A 2XYTA 3UUBA 2XYSA 4AFGA 3C79A 4IREA 5AFKA 4ZK4A 1UX2A 3UU8A 2XQ8A 2XQ6A 4HFIA 3ZKRA 2XNTA 4Z91A 5J0ZA 4Z90A 2YMEA 4TWFA 4UXUA 5HEOA 3C84A 5AFMB 2UZ6A 4UM3S 4ZR6A 5AFLA 3WTKA 3SIOA 3LSVA 2YMDA 2PGZA 5KE4A 3P50A 2BR8A 4ZJSA 5HEGA 3TLUA 5KZUA 4NZBA 2QC1B 2W8GA 3TLWA 3WTLA 4DBMA 4ZK1A 2BG9E 4AFTA 2XQ7A 4XHEA 4EZ1A 4HFHA 2Y54A 4XK9A 5AFNA 5HEJA 5HEUA 4A98A 5CO5A 3RHWA 5AFHA 2XNVA 4COFA 3RQUA 4TNVA 4TWDA 2W8FA 2WNJA 3U8MA 2WNCA 5BW2A 2YKSA 2BG9B 2Y57A 2ZJUA 3JAEA 4QH1A 5AFJA 3RQWA 1UV6A 3UQ7A 2X00D 1I9BA 3P4WA 2WZYA 2BR7A 3PMZA 2ZJVA 4ILAA 4ILCA 5L4HA 3WIPA 3JAFA 3EAMA 5TVCA 5IUXA 1UW6A 4IL4A 5SYOA 5CFBA 3SH1A 3U8JA 4QH5A 2XQ9A 4UY2A 4F8HA 2Y58A 4UM3P 2XNUA 4FRRA 4ZRUA 2Y56A 2BYRA 5J5FA 3UQ4A 4BFQA 2PH9A 4ZZCA 4NPPA 4PIRA 3UU3A 2BYPA 4TNWA 4HFEA 3SQ6A 2WNLA 5HCJA 4QH4A 3GUAA 2X00A 4HQPA 5JMEA 4HFBA 4LMKA 2XQAA 4QACA 4ILBA 5AINA 2BYNA 2Y7YA 3WTIA 2YOEA 5HEHA 3ZDGA 4ZJTA 2XQ5A 3TLSA 3EI0A 4QAAA 3U8KA 2BJ0A 4UM1A 2XZ6A 5J5IA 3WTHA 5J5GA 4ZZBA 5LXBA 3TLVA 3SQ9A 3RIFA 5FJVA 3WTOA 4UM3A 3U8LA 4BQTA 2XZ5A 4LMLA 2XQ4A 4A97A 4B5DA 2BG9A 5HCMA 3EHZA 3T4MA 3TLTA 4HFCA 4D01A 4IL9A 3RIAA 3JADA 4AFHA 3RI5A
chains in the Genus database with same CATH superfamily
3UU4A 3U8NA 2BYSA 3WTJA 3WTNA 4LMJA 2BYQA 5BP0A 2WN9A 2YN6A 2C9TA 4QABA 4TWHA 4ALXA 2BG9C 5J5HA 2XQ3A 3IGQA 2VL0A 4X5TA 5L47A 5AFMA 4HFDA 5BRXA 5L4EA 3PEOA 4WV9A 3ZDHA 3UU6A 3WTMA 3UU5A 5LG3A 2XYTA 3UUBA 2XYSA 4AFGA 3C79A 4IREA 5AFKA 4ZK4A 1UX2A 3UU8A 2XQ8A 2XQ6A 4HFIA 3ZKRA 2XNTA 4Z91A 5J0ZA 4Z90A 2YMEA 4TWFA 4UXUA 5HEOA 3C84A 5AFMB 2UZ6A 4UM3S 4ZR6A 5AFLA 3WTKA 3SIOA 3LSVA 2YMDA 2PGZA 5KE4A 3P50A 2BR8A 4ZJSA 5HEGA 3TLUA 5KZUA 4NZBA 2QC1B 2W8GA 3TLWA 3WTLA 4DBMA 4ZK1A 2BG9E 4AFTA 2XQ7A 4XHEA 4EZ1A 4HFHA 2Y54A 4XK9A 5AFNA 5HEJA 5HEUA 4A98A 5CO5A 3RHWA 5AFHA 2XNVA 4COFA 3RQUA 4TNVA 4TWDA 2W8FA 2WNJA 3U8MA 2WNCA 5BW2A 2YKSA 2BG9B 2Y57A 2ZJUA 3JAEA 4QH1A 5AFJA 3RQWA 1UV6A 3UQ7A 2X00D 1I9BA 3P4WA 2WZYA 2BR7A 3PMZA 2ZJVA 4ILAA 4ILCA 5L4HA 3WIPA 3JAFA 3EAMA 5TVCA 5IUXA 1UW6A 4IL4A 5SYOA 5CFBA 3SH1A 3U8JA 4QH5A 2XQ9A 4UY2A 4F8HA 2Y58A 4UM3P 2XNUA 4FRRA 4ZRUA 2Y56A 2BYRA 5J5FA 3UQ4A 4BFQA 2PH9A 4ZZCA 4NPPA 4PIRA 3UU3A 2BYPA 4TNWA 4HFEA 3SQ6A 2WNLA 5HCJA 4QH4A 3GUAA 2X00A 4HQPA 5JMEA 4HFBA 4LMKA 2XQAA 4QACA 4ILBA 5AINA 2BYNA 2Y7YA 3WTIA 2YOEA 5HEHA 3ZDGA 4ZJTA 2XQ5A 3TLSA 3EI0A 4QAAA 3U8KA 2BJ0A 4UM1A 2XZ6A 5J5IA 3WTHA 5J5GA 4ZZBA 5LXBA 3TLVA 3SQ9A 3RIFA 5FJVA 3WTOA 4UM3A 3U8LA 4BQTA 2XZ5A 4LMLA 2XQ4A 4A97A 4B5DA 2BG9A 5HCMA 3EHZA 3T4MA 3TLTA 4HFCA 4D01A 4IL9A 3RIAA 3JADA 4AFHA 3RI5A
chains in the Genus database with same CATH topology
3UU4A 3U8NA 2BYSA 3WTJA 3WTNA 4LMJA 2BYQA 5BP0A 2WN9A 2YN6A 2C9TA 4QABA 4TWHA 4ALXA 2BG9C 5J5HA 2XQ3A 3IGQA 2VL0A 4X5TA 5L47A 5AFMA 4HFDA 5BRXA 5L4EA 3PEOA 4WV9A 3ZDHA 3UU6A 3WTMA 3UU5A 5LG3A 2XYTA 3UUBA 2XYSA 4AFGA 3C79A 4IREA 5AFKA 4ZK4A 1UX2A 3UU8A 2XQ8A 2XQ6A 4HFIA 3ZKRA 2XNTA 4Z91A 5J0ZA 4Z90A 2YMEA 4TWFA 4UXUA 5HEOA 3C84A 5AFMB 2UZ6A 4UM3S 4ZR6A 5AFLA 3WTKA 3SIOA 3LSVA 2YMDA 2PGZA 5KE4A 3P50A 2BR8A 4ZJSA 5HEGA 3TLUA 5KZUA 4NZBA 2QC1B 2W8GA 3TLWA 3WTLA 4DBMA 4ZK1A 2BG9E 4AFTA 2XQ7A 4XHEA 4EZ1A 4HFHA 2Y54A 4XK9A 5AFNA 5HEJA 5HEUA 4A98A 5CO5A 3RHWA 5AFHA 2XNVA 4COFA 3RQUA 4TNVA 4TWDA 2W8FA 2WNJA 3U8MA 2WNCA 5BW2A 2YKSA 2BG9B 2Y57A 2ZJUA 3JAEA 4QH1A 5AFJA 3RQWA 1UV6A 3UQ7A 2X00D 1I9BA 3P4WA 2WZYA 2BR7A 3PMZA 2ZJVA 4ILAA 4ILCA 5L4HA 3WIPA 3JAFA 3EAMA 5TVCA 5IUXA 1UW6A 4IL4A 5SYOA 5CFBA 3SH1A 3U8JA 4QH5A 2XQ9A 4UY2A 4F8HA 2Y58A 4UM3P 2XNUA 4FRRA 4ZRUA 2Y56A 2BYRA 5J5FA 3UQ4A 4BFQA 2PH9A 4ZZCA 4NPPA 4PIRA 3UU3A 2BYPA 4TNWA 4HFEA 3SQ6A 2WNLA 5HCJA 4QH4A 3GUAA 2X00A 4HQPA 5JMEA 4HFBA 4LMKA 2XQAA 4QACA 4ILBA 5AINA 2BYNA 2Y7YA 3WTIA 2YOEA 5HEHA 3ZDGA 4ZJTA 2XQ5A 3TLSA 3EI0A 4QAAA 3U8KA 2BJ0A 4UM1A 2XZ6A 5J5IA 3WTHA 5J5GA 4ZZBA 5LXBA 3TLVA 3SQ9A 3RIFA 5FJVA 3WTOA 4UM3A 3U8LA 4BQTA 2XZ5A 4LMLA 2XQ4A 4A97A 4B5DA 2BG9A 5HCMA 3EHZA 3T4MA 3TLTA 4HFCA 4D01A 4IL9A 3RIAA 3JADA 4AFHA 3RI5A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3UU4 A;  3U8N A;  2BYS A;  3WTJ A;  3WTN A;  4LMJ A;  2BYQ A;  5BP0 A;  2WN9 A;  2YN6 A;  2C9T A;  4QAB A;  4TWH A;  4ALX A;  2BG9 C;  5J5H A;  2XQ3 A;  3IGQ A;  2VL0 A;  4X5T A;  5L47 A;  5AFM A;  4HFD A;  5BRX A;  5L4E A;  3PEO A;  4WV9 A;  3ZDH A;  3UU6 A;  3WTM A;  3UU5 A;  5LG3 A;  2XYT A;  3UUB A;  2XYS A;  4AFG A;  3C79 A;  4IRE A;  5AFK A;  4ZK4 A;  1UX2 A;  3UU8 A;  2XQ8 A;  2XQ6 A;  4HFI A;  3ZKR A;  2XNT A;  4Z91 A;  5J0Z A;  4Z90 A;  2YME A;  4TWF A;  4UXU A;  5HEO A;  3C84 A;  5AFM B;  2UZ6 A;  4UM3 S;  4ZR6 A;  5AFL A;  3WTK A;  3SIO A;  3LSV A;  2YMD A;  2PGZ A;  5KE4 A;  3P50 A;  2BR8 A;  4ZJS A;  5HEG A;  3TLU A;  5KZU A;  4NZB A;  2QC1 B;  2W8G A;  3TLW A;  3WTL A;  4DBM A;  4ZK1 A;  2BG9 E;  4AFT A;  2XQ7 A;  4XHE A;  4EZ1 A;  4HFH A;  2Y54 A;  4XK9 A;  5AFN A;  5HEJ A;  5HEU A;  4A98 A;  5CO5 A;  3RHW A;  5AFH A;  2XNV A;  4COF A;  3RQU A;  4TNV A;  4TWD A;  2W8F A;  2WNJ A;  3U8M A;  2WNC A;  5BW2 A;  2YKS A;  2BG9 B;  2Y57 A;  2ZJU A;  3JAE A;  4QH1 A;  5AFJ A;  3RQW A;  1UV6 A;  3UQ7 A;  2X00 D;  1I9B A;  3P4W A;  2WZY A;  2BR7 A;  3PMZ A;  2ZJV A;  4ILA A;  4ILC A;  5L4H A;  3WIP A;  3JAF A;  3EAM A;  5TVC A;  5IUX A;  1UW6 A;  4IL4 A;  5SYO A;  5CFB A;  3SH1 A;  3U8J A;  4QH5 A;  2XQ9 A;  4UY2 A;  4F8H A;  2Y58 A;  4UM3 P;  2XNU A;  4FRR A;  4ZRU A;  2Y56 A;  2BYR A;  5J5F A;  3UQ4 A;  4BFQ A;  2PH9 A;  4ZZC A;  4NPP A;  4PIR A;  3UU3 A;  2BYP A;  4TNW A;  4HFE A;  3SQ6 A;  2WNL A;  5HCJ A;  4QH4 A;  3GUA A;  2X00 A;  4HQP A;  5JME A;  4HFB A;  4LMK A;  2XQA A;  4QAC A;  4ILB A;  5AIN A;  2BYN A;  2Y7Y A;  3WTI A;  2YOE A;  5HEH A;  3ZDG A;  4ZJT A;  2XQ5 A;  3TLS A;  3EI0 A;  4QAA A;  3U8K A;  2BJ0 A;  4UM1 A;  2XZ6 A;  5J5I A;  3WTH A;  5J5G A;  4ZZB A;  5LXB A;  3TLV A;  3SQ9 A;  3RIF A;  5FJV A;  3WTO A;  4UM3 A;  3U8L A;  4BQT A;  2XZ5 A;  4LML A;  2XQ4 A;  4A97 A;  4B5D A;  2BG9 A;  5HCM A;  3EHZ A;  3T4M A;  3TLT A;  4HFC A;  4D01 A;  4IL9 A;  3RIA A;  3JAD A;  4AFH A;  3RI5 A; 
#chains in the Genus database with same CATH topology
 3UU4 A;  3U8N A;  2BYS A;  3WTJ A;  3WTN A;  4LMJ A;  2BYQ A;  5BP0 A;  2WN9 A;  2YN6 A;  2C9T A;  4QAB A;  4TWH A;  4ALX A;  2BG9 C;  5J5H A;  2XQ3 A;  3IGQ A;  2VL0 A;  4X5T A;  5L47 A;  5AFM A;  4HFD A;  5BRX A;  5L4E A;  3PEO A;  4WV9 A;  3ZDH A;  3UU6 A;  3WTM A;  3UU5 A;  5LG3 A;  2XYT A;  3UUB A;  2XYS A;  4AFG A;  3C79 A;  4IRE A;  5AFK A;  4ZK4 A;  1UX2 A;  3UU8 A;  2XQ8 A;  2XQ6 A;  4HFI A;  3ZKR A;  2XNT A;  4Z91 A;  5J0Z A;  4Z90 A;  2YME A;  4TWF A;  4UXU A;  5HEO A;  3C84 A;  5AFM B;  2UZ6 A;  4UM3 S;  4ZR6 A;  5AFL A;  3WTK A;  3SIO A;  3LSV A;  2YMD A;  2PGZ A;  5KE4 A;  3P50 A;  2BR8 A;  4ZJS A;  5HEG A;  3TLU A;  5KZU A;  4NZB A;  2QC1 B;  2W8G A;  3TLW A;  3WTL A;  4DBM A;  4ZK1 A;  2BG9 E;  4AFT A;  2XQ7 A;  4XHE A;  4EZ1 A;  4HFH A;  2Y54 A;  4XK9 A;  5AFN A;  5HEJ A;  5HEU A;  4A98 A;  5CO5 A;  3RHW A;  5AFH A;  2XNV A;  4COF A;  3RQU A;  4TNV A;  4TWD A;  2W8F A;  2WNJ A;  3U8M A;  2WNC A;  5BW2 A;  2YKS A;  2BG9 B;  2Y57 A;  2ZJU A;  3JAE A;  4QH1 A;  5AFJ A;  3RQW A;  1UV6 A;  3UQ7 A;  2X00 D;  1I9B A;  3P4W A;  2WZY A;  2BR7 A;  3PMZ A;  2ZJV A;  4ILA A;  4ILC A;  5L4H A;  3WIP A;  3JAF A;  3EAM A;  5TVC A;  5IUX A;  1UW6 A;  4IL4 A;  5SYO A;  5CFB A;  3SH1 A;  3U8J A;  4QH5 A;  2XQ9 A;  4UY2 A;  4F8H A;  2Y58 A;  4UM3 P;  2XNU A;  4FRR A;  4ZRU A;  2Y56 A;  2BYR A;  5J5F A;  3UQ4 A;  4BFQ A;  2PH9 A;  4ZZC A;  4NPP A;  4PIR A;  3UU3 A;  2BYP A;  4TNW A;  4HFE A;  3SQ6 A;  2WNL A;  5HCJ A;  4QH4 A;  3GUA A;  2X00 A;  4HQP A;  5JME A;  4HFB A;  4LMK A;  2XQA A;  4QAC A;  4ILB A;  5AIN A;  2BYN A;  2Y7Y A;  3WTI A;  2YOE A;  5HEH A;  3ZDG A;  4ZJT A;  2XQ5 A;  3TLS A;  3EI0 A;  4QAA A;  3U8K A;  2BJ0 A;  4UM1 A;  2XZ6 A;  5J5I A;  3WTH A;  5J5G A;  4ZZB A;  5LXB A;  3TLV A;  3SQ9 A;  3RIF A;  5FJV A;  3WTO A;  4UM3 A;  3U8L A;  4BQT A;  2XZ5 A;  4LML A;  2XQ4 A;  4A97 A;  4B5D A;  2BG9 A;  5HCM A;  3EHZ A;  3T4M A;  3TLT A;  4HFC A;  4D01 A;  4IL9 A;  3RIA A;  3JAD A;  4AFH A;  3RI5 A; 
#chains in the Genus database with same CATH homology
 3UU4 A;  3U8N A;  2BYS A;  3WTJ A;  3WTN A;  4LMJ A;  2BYQ A;  5BP0 A;  2WN9 A;  2YN6 A;  2C9T A;  4QAB A;  4TWH A;  4ALX A;  2BG9 C;  5J5H A;  2XQ3 A;  3IGQ A;  2VL0 A;  4X5T A;  5L47 A;  5AFM A;  4HFD A;  5BRX A;  5L4E A;  3PEO A;  4WV9 A;  3ZDH A;  3UU6 A;  3WTM A;  3UU5 A;  5LG3 A;  2XYT A;  3UUB A;  2XYS A;  4AFG A;  3C79 A;  4IRE A;  5AFK A;  4ZK4 A;  1UX2 A;  3UU8 A;  2XQ8 A;  2XQ6 A;  4HFI A;  3ZKR A;  2XNT A;  4Z91 A;  5J0Z A;  4Z90 A;  2YME A;  4TWF A;  4UXU A;  5HEO A;  3C84 A;  5AFM B;  2UZ6 A;  4UM3 S;  4ZR6 A;  5AFL A;  3WTK A;  3SIO A;  3LSV A;  2YMD A;  2PGZ A;  5KE4 A;  3P50 A;  2BR8 A;  4ZJS A;  5HEG A;  3TLU A;  5KZU A;  4NZB A;  2QC1 B;  2W8G A;  3TLW A;  3WTL A;  4DBM A;  4ZK1 A;  2BG9 E;  4AFT A;  2XQ7 A;  4XHE A;  4EZ1 A;  4HFH A;  2Y54 A;  4XK9 A;  5AFN A;  5HEJ A;  5HEU A;  4A98 A;  5CO5 A;  3RHW A;  5AFH A;  2XNV A;  4COF A;  3RQU A;  4TNV A;  4TWD A;  2W8F A;  2WNJ A;  3U8M A;  2WNC A;  5BW2 A;  2YKS A;  2BG9 B;  2Y57 A;  2ZJU A;  3JAE A;  4QH1 A;  5AFJ A;  3RQW A;  1UV6 A;  3UQ7 A;  2X00 D;  1I9B A;  3P4W A;  2WZY A;  2BR7 A;  3PMZ A;  2ZJV A;  4ILA A;  4ILC A;  5L4H A;  3WIP A;  3JAF A;  3EAM A;  5TVC A;  5IUX A;  1UW6 A;  4IL4 A;  5SYO A;  5CFB A;  3SH1 A;  3U8J A;  4QH5 A;  2XQ9 A;  4UY2 A;  4F8H A;  2Y58 A;  4UM3 P;  2XNU A;  4FRR A;  4ZRU A;  2Y56 A;  2BYR A;  5J5F A;  3UQ4 A;  4BFQ A;  2PH9 A;  4ZZC A;  4NPP A;  4PIR A;  3UU3 A;  2BYP A;  4TNW A;  4HFE A;  3SQ6 A;  2WNL A;  5HCJ A;  4QH4 A;  3GUA A;  2X00 A;  4HQP A;  5JME A;  4HFB A;  4LMK A;  2XQA A;  4QAC A;  4ILB A;  5AIN A;  2BYN A;  2Y7Y A;  3WTI A;  2YOE A;  5HEH A;  3ZDG A;  4ZJT A;  2XQ5 A;  3TLS A;  3EI0 A;  4QAA A;  3U8K A;  2BJ0 A;  4UM1 A;  2XZ6 A;  5J5I A;  3WTH A;  5J5G A;  4ZZB A;  5LXB A;  3TLV A;  3SQ9 A;  3RIF A;  5FJV A;  3WTO A;  4UM3 A;  3U8L A;  4BQT A;  2XZ5 A;  4LML A;  2XQ4 A;  4A97 A;  4B5D A;  2BG9 A;  5HCM A;  3EHZ A;  3T4M A;  3TLT A;  4HFC A;  4D01 A;  4IL9 A;  3RIA A;  3JAD A;  4AFH A;  3RI5 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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