2Y58A

Fragment growing induces conformational changes in acetylcholine- binding protein: a structural and thermodynamic analysis - (compound 6)
Total Genus 47
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
47
sequence length
205
structure length
205
Chain Sequence
QANLMRLKSDLFNRSPMYPGPTKDDPLTVTLGFTLQDIVKVDSSTNEVDLVYYEQQRWKLNSLMWDPNEYGNITDFRTSAADIWTPDITAYSSTRPVQVLSPQIAVVTHDGSVMFIPAQRLSFMCDPTGVDSEEGVTCAVKFGSWVYSGFEIDLKTDTDQVDLSSYYASSKYEILSATQTRQVQHYSCCPEPYIDVNLVVKFRER
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title Fragment Growing Induces Conformational Changes in Acetylcholine-Binding Protein: A Structural and Thermodynamic Analysis.
pubmed doi rcsb
molecule tags Receptor
source organism Aplysia californica
molecule keywords SOLUBLE ACETYLCHOLINE RECEPTOR
total genus 47
structure length 205
sequence length 205
chains with identical sequence B, C, D, E
ec nomenclature
pdb deposition date 2011-01-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02931 Neur_chan_LBD Neurotransmitter-gated ion-channel ligand binding domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.170.10 Mainly Beta Distorted Sandwich Acetylcholine Binding Protein; Chain: A, Neurotransmitter-gated ion-channel ligand-binding domain 2y58A00
2XQ7A 3PMZA 3P4WA 3WIPA 4ZK4A 3LSVA 3U8JA 4XK9A 5HCMA 3U8MA 2BG9A 2YOEA 4ILCA 4QACA 5CFBA 4IL4A 4F8HA 5LXBA 2XZ6A 3SQ9A 2WZYA 5JMEA 4DBMA 4HFEA 5KZUA 3UU5A 4HFDA 3U8KA 3RIFA 4XHEA 5J0ZA 3RQUA 3IGQA 2BYNA 2WNJA 3WTIA 4UM1A 5HEUA 4FRRA 2BYRA 2XQ6A 4BQTA 3SH1A 2XQ8A 3TLUA 4ILBA 4NZBA 5BRXA 2XQ3A 2YKSA 5HCJA 3EI0A 3WTJA 5J5IA 3UU4A 4ILAA 2BYPA 5AFHA 4HFCA 5L4HA 2W8GA 2Y54A 4ZRUA 3T4MA 3UQ7A 5SYOA 4EZ1A 1UV6A 1UW6A 5BP0A 3C79A 4WV9A 2Y56A 4QABA 4QAAA 5HEHA 4QH5A 3UU3A 3UU8A 4ZZCA 4UM3P 3WTHA 2BYQA 3U8LA 4HFHA 2X00D 2BG9B 4TWDA 3RHWA 2YMDA 3UQ4A 5FJVA 5HEJA 4QH4A 2W8FA 2BR7A 4PIRA 2XZ5A 4UXUA 5BW2A 5L4EA 5IUXA 3TLTA 3WTOA 4B5DA 4AFTA 2Y7YA 3PEOA 5AFMA 5AFLA 4ZJTA 3UUBA 2XNTA 2WN9A 5AINA 2X00A 4AFHA 2WNCA 4HFIA 2VL0A 3P50A 4ZR6A 4Z91A 5KE4A 3WTLA 3ZDHA 4ZK1A 2BR8A 2C9TA 2ZJVA 4X5TA 2QC1B 2XNUA 4IL9A 4HQPA 3TLVA 2YN6A 3WTNA 3JADA 4Z90A 4BFQA 2Y57A 2WNLA 4NPPA 1UX2A 2BJ0A 4UY2A 5LG3A 3JAFA 3RIAA 2XQ9A 2XQ4A 4TWFA 4UM3S 2YMEA 2XYSA 3EHZA 3C84A 4A98A 2BG9C 5J5HA 2XNVA 4ALXA 2PH9A 5HEOA 5J5GA 2Y58A 5TVCA 2UZ6A 3RI5A 4AFGA 3EAMA 3ZDGA 4COFA 4LMLA 4HFBA 3SQ6A 5L47A 4TNVA 4D01A 5J5FA 3GUAA 3WTMA 2BYSA 4TWHA 4LMKA 2PGZA 4ZZBA 3ZKRA 4UM3A 2XYTA 4TNWA 4LMJA 3TLSA 2XQ5A 3SIOA 3RQWA 5AFKA 3U8NA 5AFNA 5HEGA 2ZJUA 4ZJSA 3TLWA 5AFMB 5AFJA 4QH1A 3WTKA 2BG9E 4IREA 5CO5A 4A97A 3JAEA 1I9BA 2XQAA 3UU6A
chains in the Genus database with same CATH superfamily
2XQ7A 3PMZA 3P4WA 3WIPA 4ZK4A 3LSVA 3U8JA 4XK9A 5HCMA 3U8MA 2BG9A 2YOEA 4ILCA 4QACA 5CFBA 4IL4A 4F8HA 5LXBA 2XZ6A 3SQ9A 2WZYA 5JMEA 4DBMA 4HFEA 5KZUA 3UU5A 4HFDA 3U8KA 3RIFA 4XHEA 5J0ZA 3RQUA 3IGQA 2BYNA 2WNJA 3WTIA 4UM1A 5HEUA 4FRRA 2BYRA 2XQ6A 4BQTA 3SH1A 2XQ8A 3TLUA 4ILBA 4NZBA 5BRXA 2XQ3A 2YKSA 5HCJA 3EI0A 3WTJA 5J5IA 3UU4A 4ILAA 2BYPA 5AFHA 4HFCA 5L4HA 2W8GA 2Y54A 4ZRUA 3T4MA 3UQ7A 5SYOA 4EZ1A 1UV6A 1UW6A 5BP0A 3C79A 4WV9A 2Y56A 4QABA 4QAAA 5HEHA 4QH5A 3UU3A 3UU8A 4ZZCA 4UM3P 3WTHA 2BYQA 3U8LA 4HFHA 2X00D 2BG9B 4TWDA 3RHWA 2YMDA 3UQ4A 5FJVA 5HEJA 4QH4A 2W8FA 2BR7A 4PIRA 2XZ5A 4UXUA 5BW2A 5L4EA 5IUXA 3TLTA 3WTOA 4B5DA 4AFTA 2Y7YA 3PEOA 5AFMA 5AFLA 4ZJTA 3UUBA 2XNTA 2WN9A 5AINA 2X00A 4AFHA 2WNCA 4HFIA 2VL0A 3P50A 4ZR6A 4Z91A 5KE4A 3WTLA 3ZDHA 4ZK1A 2BR8A 2C9TA 2ZJVA 4X5TA 2QC1B 2XNUA 4IL9A 4HQPA 3TLVA 2YN6A 3WTNA 3JADA 4Z90A 4BFQA 2Y57A 2WNLA 4NPPA 1UX2A 2BJ0A 4UY2A 5LG3A 3JAFA 3RIAA 2XQ9A 2XQ4A 4TWFA 4UM3S 2YMEA 2XYSA 3EHZA 3C84A 4A98A 2BG9C 5J5HA 2XNVA 4ALXA 2PH9A 5HEOA 5J5GA 2Y58A 5TVCA 2UZ6A 3RI5A 4AFGA 3EAMA 3ZDGA 4COFA 4LMLA 4HFBA 3SQ6A 5L47A 4TNVA 4D01A 5J5FA 3GUAA 3WTMA 2BYSA 4TWHA 4LMKA 2PGZA 4ZZBA 3ZKRA 4UM3A 2XYTA 4TNWA 4LMJA 3TLSA 2XQ5A 3SIOA 3RQWA 5AFKA 3U8NA 5AFNA 5HEGA 2ZJUA 4ZJSA 3TLWA 5AFMB 5AFJA 4QH1A 3WTKA 2BG9E 4IREA 5CO5A 4A97A 3JAEA 1I9BA 2XQAA 3UU6A
chains in the Genus database with same CATH topology
2XQ7A 3PMZA 3P4WA 3WIPA 4ZK4A 3LSVA 3U8JA 4XK9A 5HCMA 3U8MA 2BG9A 2YOEA 4ILCA 4QACA 5CFBA 4IL4A 4F8HA 5LXBA 2XZ6A 3SQ9A 2WZYA 5JMEA 4DBMA 4HFEA 5KZUA 3UU5A 4HFDA 3U8KA 3RIFA 4XHEA 5J0ZA 3RQUA 3IGQA 2BYNA 2WNJA 3WTIA 4UM1A 5HEUA 4FRRA 2BYRA 2XQ6A 4BQTA 3SH1A 2XQ8A 3TLUA 4ILBA 4NZBA 5BRXA 2XQ3A 2YKSA 5HCJA 3EI0A 3WTJA 5J5IA 3UU4A 4ILAA 2BYPA 5AFHA 4HFCA 5L4HA 2W8GA 2Y54A 4ZRUA 3T4MA 3UQ7A 5SYOA 4EZ1A 1UV6A 1UW6A 5BP0A 3C79A 4WV9A 2Y56A 4QABA 4QAAA 5HEHA 4QH5A 3UU3A 3UU8A 4ZZCA 4UM3P 3WTHA 2BYQA 3U8LA 4HFHA 2X00D 2BG9B 4TWDA 3RHWA 2YMDA 3UQ4A 5FJVA 5HEJA 4QH4A 2W8FA 2BR7A 4PIRA 2XZ5A 4UXUA 5BW2A 5L4EA 5IUXA 3TLTA 3WTOA 4B5DA 4AFTA 2Y7YA 3PEOA 5AFMA 5AFLA 4ZJTA 3UUBA 2XNTA 2WN9A 5AINA 2X00A 4AFHA 2WNCA 4HFIA 2VL0A 3P50A 4ZR6A 4Z91A 5KE4A 3WTLA 3ZDHA 4ZK1A 2BR8A 2C9TA 2ZJVA 4X5TA 2QC1B 2XNUA 4IL9A 4HQPA 3TLVA 2YN6A 3WTNA 3JADA 4Z90A 4BFQA 2Y57A 2WNLA 4NPPA 1UX2A 2BJ0A 4UY2A 5LG3A 3JAFA 3RIAA 2XQ9A 2XQ4A 4TWFA 4UM3S 2YMEA 2XYSA 3EHZA 3C84A 4A98A 2BG9C 5J5HA 2XNVA 4ALXA 2PH9A 5HEOA 5J5GA 2Y58A 5TVCA 2UZ6A 3RI5A 4AFGA 3EAMA 3ZDGA 4COFA 4LMLA 4HFBA 3SQ6A 5L47A 4TNVA 4D01A 5J5FA 3GUAA 3WTMA 2BYSA 4TWHA 4LMKA 2PGZA 4ZZBA 3ZKRA 4UM3A 2XYTA 4TNWA 4LMJA 3TLSA 2XQ5A 3SIOA 3RQWA 5AFKA 3U8NA 5AFNA 5HEGA 2ZJUA 4ZJSA 3TLWA 5AFMB 5AFJA 4QH1A 3WTKA 2BG9E 4IREA 5CO5A 4A97A 3JAEA 1I9BA 2XQAA 3UU6A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2XQ7 A;  3PMZ A;  3P4W A;  3WIP A;  4ZK4 A;  3LSV A;  3U8J A;  4XK9 A;  5HCM A;  3U8M A;  2BG9 A;  2YOE A;  4ILC A;  4QAC A;  5CFB A;  4IL4 A;  4F8H A;  5LXB A;  2XZ6 A;  3SQ9 A;  2WZY A;  5JME A;  4DBM A;  4HFE A;  5KZU A;  3UU5 A;  4HFD A;  3U8K A;  3RIF A;  4XHE A;  5J0Z A;  3RQU A;  3IGQ A;  2BYN A;  2WNJ A;  3WTI A;  4UM1 A;  5HEU A;  4FRR A;  2BYR A;  2XQ6 A;  4BQT A;  3SH1 A;  2XQ8 A;  3TLU A;  4ILB A;  4NZB A;  5BRX A;  2XQ3 A;  2YKS A;  5HCJ A;  3EI0 A;  3WTJ A;  5J5I A;  3UU4 A;  4ILA A;  2BYP A;  5AFH A;  4HFC A;  5L4H A;  2W8G A;  2Y54 A;  4ZRU A;  3T4M A;  3UQ7 A;  5SYO A;  4EZ1 A;  1UV6 A;  1UW6 A;  5BP0 A;  3C79 A;  4WV9 A;  2Y56 A;  4QAB A;  4QAA A;  5HEH A;  4QH5 A;  3UU3 A;  3UU8 A;  4ZZC A;  4UM3 P;  3WTH A;  2BYQ A;  3U8L A;  4HFH A;  2X00 D;  2BG9 B;  4TWD A;  3RHW A;  2YMD A;  3UQ4 A;  5FJV A;  5HEJ A;  4QH4 A;  2W8F A;  2BR7 A;  4PIR A;  2XZ5 A;  4UXU A;  5BW2 A;  5L4E A;  5IUX A;  3TLT A;  3WTO A;  4B5D A;  4AFT A;  2Y7Y A;  3PEO A;  5AFM A;  5AFL A;  4ZJT A;  3UUB A;  2XNT A;  2WN9 A;  5AIN A;  2X00 A;  4AFH A;  2WNC A;  4HFI A;  2VL0 A;  3P50 A;  4ZR6 A;  4Z91 A;  5KE4 A;  3WTL A;  3ZDH A;  4ZK1 A;  2BR8 A;  2C9T A;  2ZJV A;  4X5T A;  2QC1 B;  2XNU A;  4IL9 A;  4HQP A;  3TLV A;  2YN6 A;  3WTN A;  3JAD A;  4Z90 A;  4BFQ A;  2Y57 A;  2WNL A;  4NPP A;  1UX2 A;  2BJ0 A;  4UY2 A;  5LG3 A;  3JAF A;  3RIA A;  2XQ9 A;  2XQ4 A;  4TWF A;  4UM3 S;  2YME A;  2XYS A;  3EHZ A;  3C84 A;  4A98 A;  2BG9 C;  5J5H A;  2XNV A;  4ALX A;  2PH9 A;  5HEO A;  5J5G A;  2Y58 A;  5TVC A;  2UZ6 A;  3RI5 A;  4AFG A;  3EAM A;  3ZDG A;  4COF A;  4LML A;  4HFB A;  3SQ6 A;  5L47 A;  4TNV A;  4D01 A;  5J5F A;  3GUA A;  3WTM A;  2BYS A;  4TWH A;  4LMK A;  2PGZ A;  4ZZB A;  3ZKR A;  4UM3 A;  2XYT A;  4TNW A;  4LMJ A;  3TLS A;  2XQ5 A;  3SIO A;  3RQW A;  5AFK A;  3U8N A;  5AFN A;  5HEG A;  2ZJU A;  4ZJS A;  3TLW A;  5AFM B;  5AFJ A;  4QH1 A;  3WTK A;  2BG9 E;  4IRE A;  5CO5 A;  4A97 A;  3JAE A;  1I9B A;  2XQA A;  3UU6 A; 
#chains in the Genus database with same CATH topology
 2XQ7 A;  3PMZ A;  3P4W A;  3WIP A;  4ZK4 A;  3LSV A;  3U8J A;  4XK9 A;  5HCM A;  3U8M A;  2BG9 A;  2YOE A;  4ILC A;  4QAC A;  5CFB A;  4IL4 A;  4F8H A;  5LXB A;  2XZ6 A;  3SQ9 A;  2WZY A;  5JME A;  4DBM A;  4HFE A;  5KZU A;  3UU5 A;  4HFD A;  3U8K A;  3RIF A;  4XHE A;  5J0Z A;  3RQU A;  3IGQ A;  2BYN A;  2WNJ A;  3WTI A;  4UM1 A;  5HEU A;  4FRR A;  2BYR A;  2XQ6 A;  4BQT A;  3SH1 A;  2XQ8 A;  3TLU A;  4ILB A;  4NZB A;  5BRX A;  2XQ3 A;  2YKS A;  5HCJ A;  3EI0 A;  3WTJ A;  5J5I A;  3UU4 A;  4ILA A;  2BYP A;  5AFH A;  4HFC A;  5L4H A;  2W8G A;  2Y54 A;  4ZRU A;  3T4M A;  3UQ7 A;  5SYO A;  4EZ1 A;  1UV6 A;  1UW6 A;  5BP0 A;  3C79 A;  4WV9 A;  2Y56 A;  4QAB A;  4QAA A;  5HEH A;  4QH5 A;  3UU3 A;  3UU8 A;  4ZZC A;  4UM3 P;  3WTH A;  2BYQ A;  3U8L A;  4HFH A;  2X00 D;  2BG9 B;  4TWD A;  3RHW A;  2YMD A;  3UQ4 A;  5FJV A;  5HEJ A;  4QH4 A;  2W8F A;  2BR7 A;  4PIR A;  2XZ5 A;  4UXU A;  5BW2 A;  5L4E A;  5IUX A;  3TLT A;  3WTO A;  4B5D A;  4AFT A;  2Y7Y A;  3PEO A;  5AFM A;  5AFL A;  4ZJT A;  3UUB A;  2XNT A;  2WN9 A;  5AIN A;  2X00 A;  4AFH A;  2WNC A;  4HFI A;  2VL0 A;  3P50 A;  4ZR6 A;  4Z91 A;  5KE4 A;  3WTL A;  3ZDH A;  4ZK1 A;  2BR8 A;  2C9T A;  2ZJV A;  4X5T A;  2QC1 B;  2XNU A;  4IL9 A;  4HQP A;  3TLV A;  2YN6 A;  3WTN A;  3JAD A;  4Z90 A;  4BFQ A;  2Y57 A;  2WNL A;  4NPP A;  1UX2 A;  2BJ0 A;  4UY2 A;  5LG3 A;  3JAF A;  3RIA A;  2XQ9 A;  2XQ4 A;  4TWF A;  4UM3 S;  2YME A;  2XYS A;  3EHZ A;  3C84 A;  4A98 A;  2BG9 C;  5J5H A;  2XNV A;  4ALX A;  2PH9 A;  5HEO A;  5J5G A;  2Y58 A;  5TVC A;  2UZ6 A;  3RI5 A;  4AFG A;  3EAM A;  3ZDG A;  4COF A;  4LML A;  4HFB A;  3SQ6 A;  5L47 A;  4TNV A;  4D01 A;  5J5F A;  3GUA A;  3WTM A;  2BYS A;  4TWH A;  4LMK A;  2PGZ A;  4ZZB A;  3ZKR A;  4UM3 A;  2XYT A;  4TNW A;  4LMJ A;  3TLS A;  2XQ5 A;  3SIO A;  3RQW A;  5AFK A;  3U8N A;  5AFN A;  5HEG A;  2ZJU A;  4ZJS A;  3TLW A;  5AFM B;  5AFJ A;  4QH1 A;  3WTK A;  2BG9 E;  4IRE A;  5CO5 A;  4A97 A;  3JAE A;  1I9B A;  2XQA A;  3UU6 A; 
#chains in the Genus database with same CATH homology
 2XQ7 A;  3PMZ A;  3P4W A;  3WIP A;  4ZK4 A;  3LSV A;  3U8J A;  4XK9 A;  5HCM A;  3U8M A;  2BG9 A;  2YOE A;  4ILC A;  4QAC A;  5CFB A;  4IL4 A;  4F8H A;  5LXB A;  2XZ6 A;  3SQ9 A;  2WZY A;  5JME A;  4DBM A;  4HFE A;  5KZU A;  3UU5 A;  4HFD A;  3U8K A;  3RIF A;  4XHE A;  5J0Z A;  3RQU A;  3IGQ A;  2BYN A;  2WNJ A;  3WTI A;  4UM1 A;  5HEU A;  4FRR A;  2BYR A;  2XQ6 A;  4BQT A;  3SH1 A;  2XQ8 A;  3TLU A;  4ILB A;  4NZB A;  5BRX A;  2XQ3 A;  2YKS A;  5HCJ A;  3EI0 A;  3WTJ A;  5J5I A;  3UU4 A;  4ILA A;  2BYP A;  5AFH A;  4HFC A;  5L4H A;  2W8G A;  2Y54 A;  4ZRU A;  3T4M A;  3UQ7 A;  5SYO A;  4EZ1 A;  1UV6 A;  1UW6 A;  5BP0 A;  3C79 A;  4WV9 A;  2Y56 A;  4QAB A;  4QAA A;  5HEH A;  4QH5 A;  3UU3 A;  3UU8 A;  4ZZC A;  4UM3 P;  3WTH A;  2BYQ A;  3U8L A;  4HFH A;  2X00 D;  2BG9 B;  4TWD A;  3RHW A;  2YMD A;  3UQ4 A;  5FJV A;  5HEJ A;  4QH4 A;  2W8F A;  2BR7 A;  4PIR A;  2XZ5 A;  4UXU A;  5BW2 A;  5L4E A;  5IUX A;  3TLT A;  3WTO A;  4B5D A;  4AFT A;  2Y7Y A;  3PEO A;  5AFM A;  5AFL A;  4ZJT A;  3UUB A;  2XNT A;  2WN9 A;  5AIN A;  2X00 A;  4AFH A;  2WNC A;  4HFI A;  2VL0 A;  3P50 A;  4ZR6 A;  4Z91 A;  5KE4 A;  3WTL A;  3ZDH A;  4ZK1 A;  2BR8 A;  2C9T A;  2ZJV A;  4X5T A;  2QC1 B;  2XNU A;  4IL9 A;  4HQP A;  3TLV A;  2YN6 A;  3WTN A;  3JAD A;  4Z90 A;  4BFQ A;  2Y57 A;  2WNL A;  4NPP A;  1UX2 A;  2BJ0 A;  4UY2 A;  5LG3 A;  3JAF A;  3RIA A;  2XQ9 A;  2XQ4 A;  4TWF A;  4UM3 S;  2YME A;  2XYS A;  3EHZ A;  3C84 A;  4A98 A;  2BG9 C;  5J5H A;  2XNV A;  4ALX A;  2PH9 A;  5HEO A;  5J5G A;  2Y58 A;  5TVC A;  2UZ6 A;  3RI5 A;  4AFG A;  3EAM A;  3ZDG A;  4COF A;  4LML A;  4HFB A;  3SQ6 A;  5L47 A;  4TNV A;  4D01 A;  5J5F A;  3GUA A;  3WTM A;  2BYS A;  4TWH A;  4LMK A;  2PGZ A;  4ZZB A;  3ZKR A;  4UM3 A;  2XYT A;  4TNW A;  4LMJ A;  3TLS A;  2XQ5 A;  3SIO A;  3RQW A;  5AFK A;  3U8N A;  5AFN A;  5HEG A;  2ZJU A;  4ZJS A;  3TLW A;  5AFM B;  5AFJ A;  4QH1 A;  3WTK A;  2BG9 E;  4IRE A;  5CO5 A;  4A97 A;  3JAE A;  1I9B A;  2XQA A;  3UU6 A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...