2YMDA

Crystal structure of a mutant binding protein (5htbp-achbp) in complex with serotonin (5-hydroxytryptamine)
Total Genus 48
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
48
sequence length
212
structure length
212
Chain Sequence
QANLMRLKSDLFNRSPMYPGPTKDDPLTVTLGFTLQDIVKVDSSTNEVDLVYWEQQRWKLNSLMWDPNEYGNITDFRTSAADIWTPDITAYESTRPVQVLSPQIAVVTHDGSVMFIPAQRLSFMCDPTGVDSEEGVTCALTFGSWVYSGFEIDLKTDTDQVDLSSYYASSKYEILSATQTRQVQHYSCCPEPYIDVNLVVKFRERRAGNGFF
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural Basis of Ligand Recognition in 5-Ht(3) Receptors.
pubmed doi rcsb
molecule tags Receptor
source organism Aplysia californica
molecule keywords SOLUBLE ACETYLCHOLINE RECEPTOR
total genus 48
structure length 212
sequence length 212
chains with identical sequence B, C, D, E, F, G, H, I, J
ec nomenclature
pdb deposition date 2012-10-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02931 Neur_chan_LBD Neurotransmitter-gated ion-channel ligand binding domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.170.10 Mainly Beta Distorted Sandwich Acetylcholine Binding Protein; Chain: A, Neurotransmitter-gated ion-channel ligand-binding domain 2ymdA00
4IREA 4B5DA 4ZZCA 4TWHA 3P50A 4ZJTA 4HFCA 2W8GA 2Y58A 5L4EA 3UUBA 4ILBA 2XYTA 3UU5A 4COFA 2PH9A 1I9BA 4AFTA 2XNVA 3SQ6A 4F8HA 2WNJA 5AFKA 2XQ3A 2WNCA 4UM3P 3EI0A 3T4MA 2WN9A 4BFQA 5LXBA 4ZJSA 5FJVA 3RIFA 2YMEA 4QACA 5L47A 3IGQA 3C79A 2BG9A 3UU4A 2C9TA 4HFIA 3SIOA 5AFJA 5KZUA 3TLTA 2XYSA 4HFHA 5CFBA 4ILAA 4WV9A 4TWFA 3WTIA 4XK9A 3UQ4A 4Z90A 3ZDGA 2XQ6A 5BW2A 4TNVA 4NZBA 3WIPA 3GUAA 2BR8A 4X5TA 3WTOA 5HEGA 2UZ6A 2XQ9A 4HFDA 2X00A 4D01A 5SYOA 2XNTA 3JAEA 4A98A 1UX2A 3WTNA 1UV6A 3PMZA 4NPPA 4UY2A 5KE4A 2ZJUA 4QABA 3RQUA 4FRRA 3P4WA 2XQ5A 4LMJA 2VL0A 4Z91A 3U8LA 2XZ6A 3JAFA 5HEHA 3U8JA 3U8KA 3UU6A 3WTLA 4IL4A 4AFHA 3EHZA 4ZZBA 2BYQA 4HFEA 3EAMA 4UM3S 2Y56A 5HEOA 3C84A 3PEOA 4BQTA 4XHEA 3RI5A 2X00D 2BG9B 3WTHA 3ZDHA 4ZK4A 4UXUA 4LMLA 3WTKA 2XQ4A 2BJ0A 3RHWA 2BG9E 5AINA 5BRXA 2Y54A 4DBMA 3UQ7A 4EZ1A 2Y7YA 5AFHA 4QH4A 2XQ7A 4UM1A 4ALXA 2PGZA 5AFNA 2YOEA 4TWDA 2WNLA 2Y57A 5AFLA 3UU3A 5J5HA 2QC1B 4QAAA 3WTJA 2BYPA 5J5GA 5AFMA 3U8MA 4PIRA 2BG9C 4LMKA 3TLVA 3TLSA 5J0ZA 2YKSA 3SH1A 5IUXA 5TVCA 2BYNA 2WZYA 4HQPA 5LG3A 5CO5A 3RQWA 5J5IA 5HCMA 3ZKRA 5HCJA 3UU8A 5AFMB 2XZ5A 5BP0A 2BR7A 3JADA 4HFBA 4ZRUA 5JMEA 2W8FA 4QH1A 2XQAA 3TLUA 4AFGA 5J5FA 2BYRA 2ZJVA 3U8NA 2YMDA 3RIAA 2XQ8A 4IL9A 4TNWA 3SQ9A 5HEUA 4QH5A 1UW6A 4ZR6A 2XNUA 2YN6A 2BYSA 5HEJA 3TLWA 4A97A 3LSVA 4ZK1A 4UM3A 4ILCA 5L4HA 3WTMA
chains in the Genus database with same CATH superfamily
4IREA 4B5DA 4ZZCA 4TWHA 3P50A 4ZJTA 4HFCA 2W8GA 2Y58A 5L4EA 3UUBA 4ILBA 2XYTA 3UU5A 4COFA 2PH9A 1I9BA 4AFTA 2XNVA 3SQ6A 4F8HA 2WNJA 5AFKA 2XQ3A 2WNCA 4UM3P 3EI0A 3T4MA 2WN9A 4BFQA 5LXBA 4ZJSA 5FJVA 3RIFA 2YMEA 4QACA 5L47A 3IGQA 3C79A 2BG9A 3UU4A 2C9TA 4HFIA 3SIOA 5AFJA 5KZUA 3TLTA 2XYSA 4HFHA 5CFBA 4ILAA 4WV9A 4TWFA 3WTIA 4XK9A 3UQ4A 4Z90A 3ZDGA 2XQ6A 5BW2A 4TNVA 4NZBA 3WIPA 3GUAA 2BR8A 4X5TA 3WTOA 5HEGA 2UZ6A 2XQ9A 4HFDA 2X00A 4D01A 5SYOA 2XNTA 3JAEA 4A98A 1UX2A 3WTNA 1UV6A 3PMZA 4NPPA 4UY2A 5KE4A 2ZJUA 4QABA 3RQUA 4FRRA 3P4WA 2XQ5A 4LMJA 2VL0A 4Z91A 3U8LA 2XZ6A 3JAFA 5HEHA 3U8JA 3U8KA 3UU6A 3WTLA 4IL4A 4AFHA 3EHZA 4ZZBA 2BYQA 4HFEA 3EAMA 4UM3S 2Y56A 5HEOA 3C84A 3PEOA 4BQTA 4XHEA 3RI5A 2X00D 2BG9B 3WTHA 3ZDHA 4ZK4A 4UXUA 4LMLA 3WTKA 2XQ4A 2BJ0A 3RHWA 2BG9E 5AINA 5BRXA 2Y54A 4DBMA 3UQ7A 4EZ1A 2Y7YA 5AFHA 4QH4A 2XQ7A 4UM1A 4ALXA 2PGZA 5AFNA 2YOEA 4TWDA 2WNLA 2Y57A 5AFLA 3UU3A 5J5HA 2QC1B 4QAAA 3WTJA 2BYPA 5J5GA 5AFMA 3U8MA 4PIRA 2BG9C 4LMKA 3TLVA 3TLSA 5J0ZA 2YKSA 3SH1A 5IUXA 5TVCA 2BYNA 2WZYA 4HQPA 5LG3A 5CO5A 3RQWA 5J5IA 5HCMA 3ZKRA 5HCJA 3UU8A 5AFMB 2XZ5A 5BP0A 2BR7A 3JADA 4HFBA 4ZRUA 5JMEA 2W8FA 4QH1A 2XQAA 3TLUA 4AFGA 5J5FA 2BYRA 2ZJVA 3U8NA 2YMDA 3RIAA 2XQ8A 4IL9A 4TNWA 3SQ9A 5HEUA 4QH5A 1UW6A 4ZR6A 2XNUA 2YN6A 2BYSA 5HEJA 3TLWA 4A97A 3LSVA 4ZK1A 4UM3A 4ILCA 5L4HA 3WTMA
chains in the Genus database with same CATH topology
4IREA 4B5DA 4ZZCA 4TWHA 3P50A 4ZJTA 4HFCA 2W8GA 2Y58A 5L4EA 3UUBA 4ILBA 2XYTA 3UU5A 4COFA 2PH9A 1I9BA 4AFTA 2XNVA 3SQ6A 4F8HA 2WNJA 5AFKA 2XQ3A 2WNCA 4UM3P 3EI0A 3T4MA 2WN9A 4BFQA 5LXBA 4ZJSA 5FJVA 3RIFA 2YMEA 4QACA 5L47A 3IGQA 3C79A 2BG9A 3UU4A 2C9TA 4HFIA 3SIOA 5AFJA 5KZUA 3TLTA 2XYSA 4HFHA 5CFBA 4ILAA 4WV9A 4TWFA 3WTIA 4XK9A 3UQ4A 4Z90A 3ZDGA 2XQ6A 5BW2A 4TNVA 4NZBA 3WIPA 3GUAA 2BR8A 4X5TA 3WTOA 5HEGA 2UZ6A 2XQ9A 4HFDA 2X00A 4D01A 5SYOA 2XNTA 3JAEA 4A98A 1UX2A 3WTNA 1UV6A 3PMZA 4NPPA 4UY2A 5KE4A 2ZJUA 4QABA 3RQUA 4FRRA 3P4WA 2XQ5A 4LMJA 2VL0A 4Z91A 3U8LA 2XZ6A 3JAFA 5HEHA 3U8JA 3U8KA 3UU6A 3WTLA 4IL4A 4AFHA 3EHZA 4ZZBA 2BYQA 4HFEA 3EAMA 4UM3S 2Y56A 5HEOA 3C84A 3PEOA 4BQTA 4XHEA 3RI5A 2X00D 2BG9B 3WTHA 3ZDHA 4ZK4A 4UXUA 4LMLA 3WTKA 2XQ4A 2BJ0A 3RHWA 2BG9E 5AINA 5BRXA 2Y54A 4DBMA 3UQ7A 4EZ1A 2Y7YA 5AFHA 4QH4A 2XQ7A 4UM1A 4ALXA 2PGZA 5AFNA 2YOEA 4TWDA 2WNLA 2Y57A 5AFLA 3UU3A 5J5HA 2QC1B 4QAAA 3WTJA 2BYPA 5J5GA 5AFMA 3U8MA 4PIRA 2BG9C 4LMKA 3TLVA 3TLSA 5J0ZA 2YKSA 3SH1A 5IUXA 5TVCA 2BYNA 2WZYA 4HQPA 5LG3A 5CO5A 3RQWA 5J5IA 5HCMA 3ZKRA 5HCJA 3UU8A 5AFMB 2XZ5A 5BP0A 2BR7A 3JADA 4HFBA 4ZRUA 5JMEA 2W8FA 4QH1A 2XQAA 3TLUA 4AFGA 5J5FA 2BYRA 2ZJVA 3U8NA 2YMDA 3RIAA 2XQ8A 4IL9A 4TNWA 3SQ9A 5HEUA 4QH5A 1UW6A 4ZR6A 2XNUA 2YN6A 2BYSA 5HEJA 3TLWA 4A97A 3LSVA 4ZK1A 4UM3A 4ILCA 5L4HA 3WTMA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4IRE A;  4B5D A;  4ZZC A;  4TWH A;  3P50 A;  4ZJT A;  4HFC A;  2W8G A;  2Y58 A;  5L4E A;  3UUB A;  4ILB A;  2XYT A;  3UU5 A;  4COF A;  2PH9 A;  1I9B A;  4AFT A;  2XNV A;  3SQ6 A;  4F8H A;  2WNJ A;  5AFK A;  2XQ3 A;  2WNC A;  4UM3 P;  3EI0 A;  3T4M A;  2WN9 A;  4BFQ A;  5LXB A;  4ZJS A;  5FJV A;  3RIF A;  2YME A;  4QAC A;  5L47 A;  3IGQ A;  3C79 A;  2BG9 A;  3UU4 A;  2C9T A;  4HFI A;  3SIO A;  5AFJ A;  5KZU A;  3TLT A;  2XYS A;  4HFH A;  5CFB A;  4ILA A;  4WV9 A;  4TWF A;  3WTI A;  4XK9 A;  3UQ4 A;  4Z90 A;  3ZDG A;  2XQ6 A;  5BW2 A;  4TNV A;  4NZB A;  3WIP A;  3GUA A;  2BR8 A;  4X5T A;  3WTO A;  5HEG A;  2UZ6 A;  2XQ9 A;  4HFD A;  2X00 A;  4D01 A;  5SYO A;  2XNT A;  3JAE A;  4A98 A;  1UX2 A;  3WTN A;  1UV6 A;  3PMZ A;  4NPP A;  4UY2 A;  5KE4 A;  2ZJU A;  4QAB A;  3RQU A;  4FRR A;  3P4W A;  2XQ5 A;  4LMJ A;  2VL0 A;  4Z91 A;  3U8L A;  2XZ6 A;  3JAF A;  5HEH A;  3U8J A;  3U8K A;  3UU6 A;  3WTL A;  4IL4 A;  4AFH A;  3EHZ A;  4ZZB A;  2BYQ A;  4HFE A;  3EAM A;  4UM3 S;  2Y56 A;  5HEO A;  3C84 A;  3PEO A;  4BQT A;  4XHE A;  3RI5 A;  2X00 D;  2BG9 B;  3WTH A;  3ZDH A;  4ZK4 A;  4UXU A;  4LML A;  3WTK A;  2XQ4 A;  2BJ0 A;  3RHW A;  2BG9 E;  5AIN A;  5BRX A;  2Y54 A;  4DBM A;  3UQ7 A;  4EZ1 A;  2Y7Y A;  5AFH A;  4QH4 A;  2XQ7 A;  4UM1 A;  4ALX A;  2PGZ A;  5AFN A;  2YOE A;  4TWD A;  2WNL A;  2Y57 A;  5AFL A;  3UU3 A;  5J5H A;  2QC1 B;  4QAA A;  3WTJ A;  2BYP A;  5J5G A;  5AFM A;  3U8M A;  4PIR A;  2BG9 C;  4LMK A;  3TLV A;  3TLS A;  5J0Z A;  2YKS A;  3SH1 A;  5IUX A;  5TVC A;  2BYN A;  2WZY A;  4HQP A;  5LG3 A;  5CO5 A;  3RQW A;  5J5I A;  5HCM A;  3ZKR A;  5HCJ A;  3UU8 A;  5AFM B;  2XZ5 A;  5BP0 A;  2BR7 A;  3JAD A;  4HFB A;  4ZRU A;  5JME A;  2W8F A;  4QH1 A;  2XQA A;  3TLU A;  4AFG A;  5J5F A;  2BYR A;  2ZJV A;  3U8N A;  2YMD A;  3RIA A;  2XQ8 A;  4IL9 A;  4TNW A;  3SQ9 A;  5HEU A;  4QH5 A;  1UW6 A;  4ZR6 A;  2XNU A;  2YN6 A;  2BYS A;  5HEJ A;  3TLW A;  4A97 A;  3LSV A;  4ZK1 A;  4UM3 A;  4ILC A;  5L4H A;  3WTM A; 
#chains in the Genus database with same CATH topology
 4IRE A;  4B5D A;  4ZZC A;  4TWH A;  3P50 A;  4ZJT A;  4HFC A;  2W8G A;  2Y58 A;  5L4E A;  3UUB A;  4ILB A;  2XYT A;  3UU5 A;  4COF A;  2PH9 A;  1I9B A;  4AFT A;  2XNV A;  3SQ6 A;  4F8H A;  2WNJ A;  5AFK A;  2XQ3 A;  2WNC A;  4UM3 P;  3EI0 A;  3T4M A;  2WN9 A;  4BFQ A;  5LXB A;  4ZJS A;  5FJV A;  3RIF A;  2YME A;  4QAC A;  5L47 A;  3IGQ A;  3C79 A;  2BG9 A;  3UU4 A;  2C9T A;  4HFI A;  3SIO A;  5AFJ A;  5KZU A;  3TLT A;  2XYS A;  4HFH A;  5CFB A;  4ILA A;  4WV9 A;  4TWF A;  3WTI A;  4XK9 A;  3UQ4 A;  4Z90 A;  3ZDG A;  2XQ6 A;  5BW2 A;  4TNV A;  4NZB A;  3WIP A;  3GUA A;  2BR8 A;  4X5T A;  3WTO A;  5HEG A;  2UZ6 A;  2XQ9 A;  4HFD A;  2X00 A;  4D01 A;  5SYO A;  2XNT A;  3JAE A;  4A98 A;  1UX2 A;  3WTN A;  1UV6 A;  3PMZ A;  4NPP A;  4UY2 A;  5KE4 A;  2ZJU A;  4QAB A;  3RQU A;  4FRR A;  3P4W A;  2XQ5 A;  4LMJ A;  2VL0 A;  4Z91 A;  3U8L A;  2XZ6 A;  3JAF A;  5HEH A;  3U8J A;  3U8K A;  3UU6 A;  3WTL A;  4IL4 A;  4AFH A;  3EHZ A;  4ZZB A;  2BYQ A;  4HFE A;  3EAM A;  4UM3 S;  2Y56 A;  5HEO A;  3C84 A;  3PEO A;  4BQT A;  4XHE A;  3RI5 A;  2X00 D;  2BG9 B;  3WTH A;  3ZDH A;  4ZK4 A;  4UXU A;  4LML A;  3WTK A;  2XQ4 A;  2BJ0 A;  3RHW A;  2BG9 E;  5AIN A;  5BRX A;  2Y54 A;  4DBM A;  3UQ7 A;  4EZ1 A;  2Y7Y A;  5AFH A;  4QH4 A;  2XQ7 A;  4UM1 A;  4ALX A;  2PGZ A;  5AFN A;  2YOE A;  4TWD A;  2WNL A;  2Y57 A;  5AFL A;  3UU3 A;  5J5H A;  2QC1 B;  4QAA A;  3WTJ A;  2BYP A;  5J5G A;  5AFM A;  3U8M A;  4PIR A;  2BG9 C;  4LMK A;  3TLV A;  3TLS A;  5J0Z A;  2YKS A;  3SH1 A;  5IUX A;  5TVC A;  2BYN A;  2WZY A;  4HQP A;  5LG3 A;  5CO5 A;  3RQW A;  5J5I A;  5HCM A;  3ZKR A;  5HCJ A;  3UU8 A;  5AFM B;  2XZ5 A;  5BP0 A;  2BR7 A;  3JAD A;  4HFB A;  4ZRU A;  5JME A;  2W8F A;  4QH1 A;  2XQA A;  3TLU A;  4AFG A;  5J5F A;  2BYR A;  2ZJV A;  3U8N A;  2YMD A;  3RIA A;  2XQ8 A;  4IL9 A;  4TNW A;  3SQ9 A;  5HEU A;  4QH5 A;  1UW6 A;  4ZR6 A;  2XNU A;  2YN6 A;  2BYS A;  5HEJ A;  3TLW A;  4A97 A;  3LSV A;  4ZK1 A;  4UM3 A;  4ILC A;  5L4H A;  3WTM A; 
#chains in the Genus database with same CATH homology
 4IRE A;  4B5D A;  4ZZC A;  4TWH A;  3P50 A;  4ZJT A;  4HFC A;  2W8G A;  2Y58 A;  5L4E A;  3UUB A;  4ILB A;  2XYT A;  3UU5 A;  4COF A;  2PH9 A;  1I9B A;  4AFT A;  2XNV A;  3SQ6 A;  4F8H A;  2WNJ A;  5AFK A;  2XQ3 A;  2WNC A;  4UM3 P;  3EI0 A;  3T4M A;  2WN9 A;  4BFQ A;  5LXB A;  4ZJS A;  5FJV A;  3RIF A;  2YME A;  4QAC A;  5L47 A;  3IGQ A;  3C79 A;  2BG9 A;  3UU4 A;  2C9T A;  4HFI A;  3SIO A;  5AFJ A;  5KZU A;  3TLT A;  2XYS A;  4HFH A;  5CFB A;  4ILA A;  4WV9 A;  4TWF A;  3WTI A;  4XK9 A;  3UQ4 A;  4Z90 A;  3ZDG A;  2XQ6 A;  5BW2 A;  4TNV A;  4NZB A;  3WIP A;  3GUA A;  2BR8 A;  4X5T A;  3WTO A;  5HEG A;  2UZ6 A;  2XQ9 A;  4HFD A;  2X00 A;  4D01 A;  5SYO A;  2XNT A;  3JAE A;  4A98 A;  1UX2 A;  3WTN A;  1UV6 A;  3PMZ A;  4NPP A;  4UY2 A;  5KE4 A;  2ZJU A;  4QAB A;  3RQU A;  4FRR A;  3P4W A;  2XQ5 A;  4LMJ A;  2VL0 A;  4Z91 A;  3U8L A;  2XZ6 A;  3JAF A;  5HEH A;  3U8J A;  3U8K A;  3UU6 A;  3WTL A;  4IL4 A;  4AFH A;  3EHZ A;  4ZZB A;  2BYQ A;  4HFE A;  3EAM A;  4UM3 S;  2Y56 A;  5HEO A;  3C84 A;  3PEO A;  4BQT A;  4XHE A;  3RI5 A;  2X00 D;  2BG9 B;  3WTH A;  3ZDH A;  4ZK4 A;  4UXU A;  4LML A;  3WTK A;  2XQ4 A;  2BJ0 A;  3RHW A;  2BG9 E;  5AIN A;  5BRX A;  2Y54 A;  4DBM A;  3UQ7 A;  4EZ1 A;  2Y7Y A;  5AFH A;  4QH4 A;  2XQ7 A;  4UM1 A;  4ALX A;  2PGZ A;  5AFN A;  2YOE A;  4TWD A;  2WNL A;  2Y57 A;  5AFL A;  3UU3 A;  5J5H A;  2QC1 B;  4QAA A;  3WTJ A;  2BYP A;  5J5G A;  5AFM A;  3U8M A;  4PIR A;  2BG9 C;  4LMK A;  3TLV A;  3TLS A;  5J0Z A;  2YKS A;  3SH1 A;  5IUX A;  5TVC A;  2BYN A;  2WZY A;  4HQP A;  5LG3 A;  5CO5 A;  3RQW A;  5J5I A;  5HCM A;  3ZKR A;  5HCJ A;  3UU8 A;  5AFM B;  2XZ5 A;  5BP0 A;  2BR7 A;  3JAD A;  4HFB A;  4ZRU A;  5JME A;  2W8F A;  4QH1 A;  2XQA A;  3TLU A;  4AFG A;  5J5F A;  2BYR A;  2ZJV A;  3U8N A;  2YMD A;  3RIA A;  2XQ8 A;  4IL9 A;  4TNW A;  3SQ9 A;  5HEU A;  4QH5 A;  1UW6 A;  4ZR6 A;  2XNU A;  2YN6 A;  2BYS A;  5HEJ A;  3TLW A;  4A97 A;  3LSV A;  4ZK1 A;  4UM3 A;  4ILC A;  5L4H A;  3WTM A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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