2Y58A

Fragment growing induces conformational changes in acetylcholine- binding protein: a structural and thermodynamic analysis - (compound 6)
Total Genus 47
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
47
sequence length
205
structure length
205
Chain Sequence
QANLMRLKSDLFNRSPMYPGPTKDDPLTVTLGFTLQDIVKVDSSTNEVDLVYYEQQRWKLNSLMWDPNEYGNITDFRTSAADIWTPDITAYSSTRPVQVLSPQIAVVTHDGSVMFIPAQRLSFMCDPTGVDSEEGVTCAVKFGSWVYSGFEIDLKTDTDQVDLSSYYASSKYEILSATQTRQVQHYSCCPEPYIDVNLVVKFRER
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Receptor
source organism Aplysia californica
publication title Fragment Growing Induces Conformational Changes in Acetylcholine-Binding Protein: A Structural and Thermodynamic Analysis.
pubmed doi rcsb
molecule keywords SOLUBLE ACETYLCHOLINE RECEPTOR
total genus 47
structure length 205
sequence length 205
chains with identical sequence B, C, D, E
ec nomenclature
pdb deposition date 2011-01-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02931 Neur_chan_LBD Neurotransmitter-gated ion-channel ligand binding domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.170.10 Mainly Beta Distorted Sandwich Acetylcholine Binding Protein; Chain: A, Neurotransmitter-gated ion-channel ligand-binding domain 2y58A00
3UU8A 3SH1A 5AFHA 2VL0A 2WZYA 3EI0A 4NPPA 5AFNA 3T4MA 5J0ZA 2XQ7A 3UU5A 5HEHA 4ILAA 2ZJVA 4BFQA 5BP0A 3JAFA 4QAAA 4AFGA 4ZK1A 3SQ6A 5JMEA 4AFTA 3TLWA 5J5HA 4UXUA 2BG9C 2Y54A 2BR8A 2XZ5A 2UZ6A 3C79A 4HFEA 3ZDGA 5AFLA 3UU6A 4HFBA 4ZZBA 2X00D 4TWHA 4HFIA 2WNCA 3GUAA 2BJ0A 2WNJA 3EHZA 4TWDA 3U8JA 5HEJA 2XQ5A 3WTNA 2XNVA 4QH1A 4LMKA 3SQ9A 5AFKA 4ALXA 5LXBA 2BG9B 3TLVA 2C9TA 5HCMA 4XHEA 1UW6A 5HEUA 2ZJUA 2X00A 2Y58A 5CO5A 2YMEA 3WTJA 3PEOA 3JAEA 3U8KA 4WV9A 2WNLA 3WTLA 4UM3A 2XQAA 3EAMA 4ZJSA 2YN6A 2XZ6A 4HFDA 2XQ6A 3P4WA 2Y57A 3WTMA 4Z90A 4UM3S 4TWFA 4FRRA 4PIRA 2BG9E 4D01A 4EZ1A 2BR7A 3UU4A 5IUXA 3TLTA 5AFMB 4TNVA 5SYOA 2WN9A 3WIPA 4ZJTA 3U8LA 4QABA 4A97A 5BW2A 1I9BA 5HEOA 2BG9A 2PH9A 4A98A 2XNTA 4QH5A 2XNUA 2XYSA 4NZBA 2XQ4A 4ZK4A 4BQTA 5KE4A 4XK9A 4IREA 4HFHA 4QACA 4TNWA 3RHWA 4X5TA 3WTHA 2XQ9A 3SIOA 4ZR6A 4ZZCA 4IL4A 2BYPA 4F8HA 3UQ4A 4AFHA 3RI5A 5FJVA 5KZUA 4Z91A 3RQUA 2PGZA 2QC1B 4UY2A 4ILBA 3TLSA 2YKSA 3IGQA 5AFMA 5J5GA 3LSVA 4ZRUA 2BYSA 3WTOA 5TVCA 2XYTA 4IL9A 4B5DA 2BYNA 3RQWA 5LG3A 5L4EA 1UV6A 3WTKA 3WTIA 3RIAA 3ZDHA 4COFA 4LMLA 3TLUA 2Y56A 4DBMA 2W8FA 2YOEA 5J5FA 3C84A 4QH4A 3U8MA 3UQ7A 1UX2A 4HFCA 5L47A 3PMZA 5AFJA 3JADA 5J5IA 3P50A 5CFBA 3UUBA 3UU3A 2XQ3A 2XQ8A 2BYRA 5HCJA 2BYQA 2YMDA 2W8GA 2Y7YA 3ZKRA 5BRXA 4ILCA 4HQPA 5L4HA 4LMJA 4UM3P 3RIFA 4UM1A 5AINA 3U8NA 5HEGA
chains in the Genus database with same CATH superfamily
3UU8A 3SH1A 5AFHA 2VL0A 2WZYA 3EI0A 4NPPA 5AFNA 3T4MA 5J0ZA 2XQ7A 3UU5A 5HEHA 4ILAA 2ZJVA 4BFQA 5BP0A 3JAFA 4QAAA 4AFGA 4ZK1A 3SQ6A 5JMEA 4AFTA 3TLWA 5J5HA 4UXUA 2BG9C 2Y54A 2BR8A 2XZ5A 2UZ6A 3C79A 4HFEA 3ZDGA 5AFLA 3UU6A 4HFBA 4ZZBA 2X00D 4TWHA 4HFIA 2WNCA 3GUAA 2BJ0A 2WNJA 3EHZA 4TWDA 3U8JA 5HEJA 2XQ5A 3WTNA 2XNVA 4QH1A 4LMKA 3SQ9A 5AFKA 4ALXA 5LXBA 2BG9B 3TLVA 2C9TA 5HCMA 4XHEA 1UW6A 5HEUA 2ZJUA 2X00A 2Y58A 5CO5A 2YMEA 3WTJA 3PEOA 3JAEA 3U8KA 4WV9A 2WNLA 3WTLA 4UM3A 2XQAA 3EAMA 4ZJSA 2YN6A 2XZ6A 4HFDA 2XQ6A 3P4WA 2Y57A 3WTMA 4Z90A 4UM3S 4TWFA 4FRRA 4PIRA 2BG9E 4D01A 4EZ1A 2BR7A 3UU4A 5IUXA 3TLTA 5AFMB 4TNVA 5SYOA 2WN9A 3WIPA 4ZJTA 3U8LA 4QABA 4A97A 5BW2A 1I9BA 5HEOA 2BG9A 2PH9A 4A98A 2XNTA 4QH5A 2XNUA 2XYSA 4NZBA 2XQ4A 4ZK4A 4BQTA 5KE4A 4XK9A 4IREA 4HFHA 4QACA 4TNWA 3RHWA 4X5TA 3WTHA 2XQ9A 3SIOA 4ZR6A 4ZZCA 4IL4A 2BYPA 4F8HA 3UQ4A 4AFHA 3RI5A 5FJVA 5KZUA 4Z91A 3RQUA 2PGZA 2QC1B 4UY2A 4ILBA 3TLSA 2YKSA 3IGQA 5AFMA 5J5GA 3LSVA 4ZRUA 2BYSA 3WTOA 5TVCA 2XYTA 4IL9A 4B5DA 2BYNA 3RQWA 5LG3A 5L4EA 1UV6A 3WTKA 3WTIA 3RIAA 3ZDHA 4COFA 4LMLA 3TLUA 2Y56A 4DBMA 2W8FA 2YOEA 5J5FA 3C84A 4QH4A 3U8MA 3UQ7A 1UX2A 4HFCA 5L47A 3PMZA 5AFJA 3JADA 5J5IA 3P50A 5CFBA 3UUBA 3UU3A 2XQ3A 2XQ8A 2BYRA 5HCJA 2BYQA 2YMDA 2W8GA 2Y7YA 3ZKRA 5BRXA 4ILCA 4HQPA 5L4HA 4LMJA 4UM3P 3RIFA 4UM1A 5AINA 3U8NA 5HEGA
chains in the Genus database with same CATH topology
3UU8A 3SH1A 5AFHA 2VL0A 2WZYA 3EI0A 4NPPA 5AFNA 3T4MA 5J0ZA 2XQ7A 3UU5A 5HEHA 4ILAA 2ZJVA 4BFQA 5BP0A 3JAFA 4QAAA 4AFGA 4ZK1A 3SQ6A 5JMEA 4AFTA 3TLWA 5J5HA 4UXUA 2BG9C 2Y54A 2BR8A 2XZ5A 2UZ6A 3C79A 4HFEA 3ZDGA 5AFLA 3UU6A 4HFBA 4ZZBA 2X00D 4TWHA 4HFIA 2WNCA 3GUAA 2BJ0A 2WNJA 3EHZA 4TWDA 3U8JA 5HEJA 2XQ5A 3WTNA 2XNVA 4QH1A 4LMKA 3SQ9A 5AFKA 4ALXA 5LXBA 2BG9B 3TLVA 2C9TA 5HCMA 4XHEA 1UW6A 5HEUA 2ZJUA 2X00A 2Y58A 5CO5A 2YMEA 3WTJA 3PEOA 3JAEA 3U8KA 4WV9A 2WNLA 3WTLA 4UM3A 2XQAA 3EAMA 4ZJSA 2YN6A 2XZ6A 4HFDA 2XQ6A 3P4WA 2Y57A 3WTMA 4Z90A 4UM3S 4TWFA 4FRRA 4PIRA 2BG9E 4D01A 4EZ1A 2BR7A 3UU4A 5IUXA 3TLTA 5AFMB 4TNVA 5SYOA 2WN9A 3WIPA 4ZJTA 3U8LA 4QABA 4A97A 5BW2A 1I9BA 5HEOA 2BG9A 2PH9A 4A98A 2XNTA 4QH5A 2XNUA 2XYSA 4NZBA 2XQ4A 4ZK4A 4BQTA 5KE4A 4XK9A 4IREA 4HFHA 4QACA 4TNWA 3RHWA 4X5TA 3WTHA 2XQ9A 3SIOA 4ZR6A 4ZZCA 4IL4A 2BYPA 4F8HA 3UQ4A 4AFHA 3RI5A 5FJVA 5KZUA 4Z91A 3RQUA 2PGZA 2QC1B 4UY2A 4ILBA 3TLSA 2YKSA 3IGQA 5AFMA 5J5GA 3LSVA 4ZRUA 2BYSA 3WTOA 5TVCA 2XYTA 4IL9A 4B5DA 2BYNA 3RQWA 5LG3A 5L4EA 1UV6A 3WTKA 3WTIA 3RIAA 3ZDHA 4COFA 4LMLA 3TLUA 2Y56A 4DBMA 2W8FA 2YOEA 5J5FA 3C84A 4QH4A 3U8MA 3UQ7A 1UX2A 4HFCA 5L47A 3PMZA 5AFJA 3JADA 5J5IA 3P50A 5CFBA 3UUBA 3UU3A 2XQ3A 2XQ8A 2BYRA 5HCJA 2BYQA 2YMDA 2W8GA 2Y7YA 3ZKRA 5BRXA 4ILCA 4HQPA 5L4HA 4LMJA 4UM3P 3RIFA 4UM1A 5AINA 3U8NA 5HEGA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3UU8 A;  3SH1 A;  5AFH A;  2VL0 A;  2WZY A;  3EI0 A;  4NPP A;  5AFN A;  3T4M A;  5J0Z A;  2XQ7 A;  3UU5 A;  5HEH A;  4ILA A;  2ZJV A;  4BFQ A;  5BP0 A;  3JAF A;  4QAA A;  4AFG A;  4ZK1 A;  3SQ6 A;  5JME A;  4AFT A;  3TLW A;  5J5H A;  4UXU A;  2BG9 C;  2Y54 A;  2BR8 A;  2XZ5 A;  2UZ6 A;  3C79 A;  4HFE A;  3ZDG A;  5AFL A;  3UU6 A;  4HFB A;  4ZZB A;  2X00 D;  4TWH A;  4HFI A;  2WNC A;  3GUA A;  2BJ0 A;  2WNJ A;  3EHZ A;  4TWD A;  3U8J A;  5HEJ A;  2XQ5 A;  3WTN A;  2XNV A;  4QH1 A;  4LMK A;  3SQ9 A;  5AFK A;  4ALX A;  5LXB A;  2BG9 B;  3TLV A;  2C9T A;  5HCM A;  4XHE A;  1UW6 A;  5HEU A;  2ZJU A;  2X00 A;  2Y58 A;  5CO5 A;  2YME A;  3WTJ A;  3PEO A;  3JAE A;  3U8K A;  4WV9 A;  2WNL A;  3WTL A;  4UM3 A;  2XQA A;  3EAM A;  4ZJS A;  2YN6 A;  2XZ6 A;  4HFD A;  2XQ6 A;  3P4W A;  2Y57 A;  3WTM A;  4Z90 A;  4UM3 S;  4TWF A;  4FRR A;  4PIR A;  2BG9 E;  4D01 A;  4EZ1 A;  2BR7 A;  3UU4 A;  5IUX A;  3TLT A;  5AFM B;  4TNV A;  5SYO A;  2WN9 A;  3WIP A;  4ZJT A;  3U8L A;  4QAB A;  4A97 A;  5BW2 A;  1I9B A;  5HEO A;  2BG9 A;  2PH9 A;  4A98 A;  2XNT A;  4QH5 A;  2XNU A;  2XYS A;  4NZB A;  2XQ4 A;  4ZK4 A;  4BQT A;  5KE4 A;  4XK9 A;  4IRE A;  4HFH A;  4QAC A;  4TNW A;  3RHW A;  4X5T A;  3WTH A;  2XQ9 A;  3SIO A;  4ZR6 A;  4ZZC A;  4IL4 A;  2BYP A;  4F8H A;  3UQ4 A;  4AFH A;  3RI5 A;  5FJV A;  5KZU A;  4Z91 A;  3RQU A;  2PGZ A;  2QC1 B;  4UY2 A;  4ILB A;  3TLS A;  2YKS A;  3IGQ A;  5AFM A;  5J5G A;  3LSV A;  4ZRU A;  2BYS A;  3WTO A;  5TVC A;  2XYT A;  4IL9 A;  4B5D A;  2BYN A;  3RQW A;  5LG3 A;  5L4E A;  1UV6 A;  3WTK A;  3WTI A;  3RIA A;  3ZDH A;  4COF A;  4LML A;  3TLU A;  2Y56 A;  4DBM A;  2W8F A;  2YOE A;  5J5F A;  3C84 A;  4QH4 A;  3U8M A;  3UQ7 A;  1UX2 A;  4HFC A;  5L47 A;  3PMZ A;  5AFJ A;  3JAD A;  5J5I A;  3P50 A;  5CFB A;  3UUB A;  3UU3 A;  2XQ3 A;  2XQ8 A;  2BYR A;  5HCJ A;  2BYQ A;  2YMD A;  2W8G A;  2Y7Y A;  3ZKR A;  5BRX A;  4ILC A;  4HQP A;  5L4H A;  4LMJ A;  4UM3 P;  3RIF A;  4UM1 A;  5AIN A;  3U8N A;  5HEG A; 
#chains in the Genus database with same CATH topology
 3UU8 A;  3SH1 A;  5AFH A;  2VL0 A;  2WZY A;  3EI0 A;  4NPP A;  5AFN A;  3T4M A;  5J0Z A;  2XQ7 A;  3UU5 A;  5HEH A;  4ILA A;  2ZJV A;  4BFQ A;  5BP0 A;  3JAF A;  4QAA A;  4AFG A;  4ZK1 A;  3SQ6 A;  5JME A;  4AFT A;  3TLW A;  5J5H A;  4UXU A;  2BG9 C;  2Y54 A;  2BR8 A;  2XZ5 A;  2UZ6 A;  3C79 A;  4HFE A;  3ZDG A;  5AFL A;  3UU6 A;  4HFB A;  4ZZB A;  2X00 D;  4TWH A;  4HFI A;  2WNC A;  3GUA A;  2BJ0 A;  2WNJ A;  3EHZ A;  4TWD A;  3U8J A;  5HEJ A;  2XQ5 A;  3WTN A;  2XNV A;  4QH1 A;  4LMK A;  3SQ9 A;  5AFK A;  4ALX A;  5LXB A;  2BG9 B;  3TLV A;  2C9T A;  5HCM A;  4XHE A;  1UW6 A;  5HEU A;  2ZJU A;  2X00 A;  2Y58 A;  5CO5 A;  2YME A;  3WTJ A;  3PEO A;  3JAE A;  3U8K A;  4WV9 A;  2WNL A;  3WTL A;  4UM3 A;  2XQA A;  3EAM A;  4ZJS A;  2YN6 A;  2XZ6 A;  4HFD A;  2XQ6 A;  3P4W A;  2Y57 A;  3WTM A;  4Z90 A;  4UM3 S;  4TWF A;  4FRR A;  4PIR A;  2BG9 E;  4D01 A;  4EZ1 A;  2BR7 A;  3UU4 A;  5IUX A;  3TLT A;  5AFM B;  4TNV A;  5SYO A;  2WN9 A;  3WIP A;  4ZJT A;  3U8L A;  4QAB A;  4A97 A;  5BW2 A;  1I9B A;  5HEO A;  2BG9 A;  2PH9 A;  4A98 A;  2XNT A;  4QH5 A;  2XNU A;  2XYS A;  4NZB A;  2XQ4 A;  4ZK4 A;  4BQT A;  5KE4 A;  4XK9 A;  4IRE A;  4HFH A;  4QAC A;  4TNW A;  3RHW A;  4X5T A;  3WTH A;  2XQ9 A;  3SIO A;  4ZR6 A;  4ZZC A;  4IL4 A;  2BYP A;  4F8H A;  3UQ4 A;  4AFH A;  3RI5 A;  5FJV A;  5KZU A;  4Z91 A;  3RQU A;  2PGZ A;  2QC1 B;  4UY2 A;  4ILB A;  3TLS A;  2YKS A;  3IGQ A;  5AFM A;  5J5G A;  3LSV A;  4ZRU A;  2BYS A;  3WTO A;  5TVC A;  2XYT A;  4IL9 A;  4B5D A;  2BYN A;  3RQW A;  5LG3 A;  5L4E A;  1UV6 A;  3WTK A;  3WTI A;  3RIA A;  3ZDH A;  4COF A;  4LML A;  3TLU A;  2Y56 A;  4DBM A;  2W8F A;  2YOE A;  5J5F A;  3C84 A;  4QH4 A;  3U8M A;  3UQ7 A;  1UX2 A;  4HFC A;  5L47 A;  3PMZ A;  5AFJ A;  3JAD A;  5J5I A;  3P50 A;  5CFB A;  3UUB A;  3UU3 A;  2XQ3 A;  2XQ8 A;  2BYR A;  5HCJ A;  2BYQ A;  2YMD A;  2W8G A;  2Y7Y A;  3ZKR A;  5BRX A;  4ILC A;  4HQP A;  5L4H A;  4LMJ A;  4UM3 P;  3RIF A;  4UM1 A;  5AIN A;  3U8N A;  5HEG A; 
#chains in the Genus database with same CATH homology
 3UU8 A;  3SH1 A;  5AFH A;  2VL0 A;  2WZY A;  3EI0 A;  4NPP A;  5AFN A;  3T4M A;  5J0Z A;  2XQ7 A;  3UU5 A;  5HEH A;  4ILA A;  2ZJV A;  4BFQ A;  5BP0 A;  3JAF A;  4QAA A;  4AFG A;  4ZK1 A;  3SQ6 A;  5JME A;  4AFT A;  3TLW A;  5J5H A;  4UXU A;  2BG9 C;  2Y54 A;  2BR8 A;  2XZ5 A;  2UZ6 A;  3C79 A;  4HFE A;  3ZDG A;  5AFL A;  3UU6 A;  4HFB A;  4ZZB A;  2X00 D;  4TWH A;  4HFI A;  2WNC A;  3GUA A;  2BJ0 A;  2WNJ A;  3EHZ A;  4TWD A;  3U8J A;  5HEJ A;  2XQ5 A;  3WTN A;  2XNV A;  4QH1 A;  4LMK A;  3SQ9 A;  5AFK A;  4ALX A;  5LXB A;  2BG9 B;  3TLV A;  2C9T A;  5HCM A;  4XHE A;  1UW6 A;  5HEU A;  2ZJU A;  2X00 A;  2Y58 A;  5CO5 A;  2YME A;  3WTJ A;  3PEO A;  3JAE A;  3U8K A;  4WV9 A;  2WNL A;  3WTL A;  4UM3 A;  2XQA A;  3EAM A;  4ZJS A;  2YN6 A;  2XZ6 A;  4HFD A;  2XQ6 A;  3P4W A;  2Y57 A;  3WTM A;  4Z90 A;  4UM3 S;  4TWF A;  4FRR A;  4PIR A;  2BG9 E;  4D01 A;  4EZ1 A;  2BR7 A;  3UU4 A;  5IUX A;  3TLT A;  5AFM B;  4TNV A;  5SYO A;  2WN9 A;  3WIP A;  4ZJT A;  3U8L A;  4QAB A;  4A97 A;  5BW2 A;  1I9B A;  5HEO A;  2BG9 A;  2PH9 A;  4A98 A;  2XNT A;  4QH5 A;  2XNU A;  2XYS A;  4NZB A;  2XQ4 A;  4ZK4 A;  4BQT A;  5KE4 A;  4XK9 A;  4IRE A;  4HFH A;  4QAC A;  4TNW A;  3RHW A;  4X5T A;  3WTH A;  2XQ9 A;  3SIO A;  4ZR6 A;  4ZZC A;  4IL4 A;  2BYP A;  4F8H A;  3UQ4 A;  4AFH A;  3RI5 A;  5FJV A;  5KZU A;  4Z91 A;  3RQU A;  2PGZ A;  2QC1 B;  4UY2 A;  4ILB A;  3TLS A;  2YKS A;  3IGQ A;  5AFM A;  5J5G A;  3LSV A;  4ZRU A;  2BYS A;  3WTO A;  5TVC A;  2XYT A;  4IL9 A;  4B5D A;  2BYN A;  3RQW A;  5LG3 A;  5L4E A;  1UV6 A;  3WTK A;  3WTI A;  3RIA A;  3ZDH A;  4COF A;  4LML A;  3TLU A;  2Y56 A;  4DBM A;  2W8F A;  2YOE A;  5J5F A;  3C84 A;  4QH4 A;  3U8M A;  3UQ7 A;  1UX2 A;  4HFC A;  5L47 A;  3PMZ A;  5AFJ A;  3JAD A;  5J5I A;  3P50 A;  5CFB A;  3UUB A;  3UU3 A;  2XQ3 A;  2XQ8 A;  2BYR A;  5HCJ A;  2BYQ A;  2YMD A;  2W8G A;  2Y7Y A;  3ZKR A;  5BRX A;  4ILC A;  4HQP A;  5L4H A;  4LMJ A;  4UM3 P;  3RIF A;  4UM1 A;  5AIN A;  3U8N A;  5HEG A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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