3SQ6A

Crystal structures of the ligand binding domain of a pentameric alpha7 nicotinic receptor chimera with its agonist epibatidine
Total Genus 45
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
45
sequence length
204
structure length
204
Chain Sequence
EFQRKLYKELVKNYNPDVIPTQRDRPVTVYFSLSLLQIMDVDEKNQVVDVVFWLQMSWTDHYLQWNVSEYPGVKQVSVPISSLWVPDLAAYNAISKPEVLTPQLALVNSSGHVQYLPSIRQRFSCDVSGVDTESGATCKLKFGSWTHHSRELDLQMQEADISGYIPYSRFELVGVTQKRSERFYECCKEPYPDVTFTVTFRKKG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Ligand-binding domain of an alpha 7-nicotinic receptor chimera and its complex with agonist.
pubmed doi rcsb
molecule tags Transport protein/receptor/agonist
source organism Homo sapiens, lymnaea stagnalis
molecule keywords Neuronal acetylcholine receptor subunit alpha-7, Acetylcholi
total genus 45
structure length 204
sequence length 204
chains with identical sequence B, C, D, E, F, G, H, I, J
ec nomenclature
pdb deposition date 2011-07-05
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.170.10 Mainly Beta Distorted Sandwich Acetylcholine Binding Protein; Chain: A, Neurotransmitter-gated ion-channel ligand-binding domain 3sq6A00
2YMDA 3JADA 5BRXA 2X00A 3UQ4A 5CFBA 5CO5A 5JMEA 4DBMA 2BYQA 2X00D 3LSVA 3JAFA 4QH1A 3RI5A 1UX2A 4ILBA 3WTIA 2BYNA 5HEGA 5HEUA 4ZZBA 2Y57A 4ZK4A 4HFBA 3RQWA 4F8HA 3U8MA 4QABA 2Y7YA 4UM3A 4A97A 3SQ9A 3WTJA 4HFIA 3RHWA 3TLTA 5HEOA 3U8KA 4FRRA 2WZYA 4WV9A 4ZK1A 4AFTA 4AFHA 4D01A 4UM3S 2YOEA 4X5TA 4UY2A 5BW2A 4HQPA 4HFDA 5L47A 5LG3A 2Y56A 4QACA 3ZKRA 3WIPA 4TWFA 3C84A 5HCJA 2XYTA 4ZR6A 4TNVA 3P4WA 2BG9E 3SIOA 2YKSA 4LMKA 5TVCA 4TWHA 5KZUA 2YN6A 4Z91A 2XQ9A 3P50A 2XQ6A 5J0ZA 5HEHA 2BR7A 4IL4A 3UU6A 5AFKA 2WNLA 2XQAA 2W8GA 2YMEA 4UXUA 4XK9A 3WTHA 3C79A 5J5HA 3ZDGA 3TLWA 2XZ5A 3JAEA 5L4HA 2XYSA 3UUBA 5AFMA 4TWDA 5J5GA 3T4MA 3U8NA 5J5FA 2WNJA 2BG9B 2BR8A 4LMJA 2XNVA 2XQ4A 3UU8A 2BYSA 4TNWA 3RQUA 4ZJSA 5SYOA 3SH1A 3U8JA 3WTKA 3EAMA 3GUAA 5HEJA 2VL0A 3UU5A 2Y54A 1I9BA 3WTNA 2XZ6A 4LMLA 2BYPA 4ILCA 4IREA 3ZDHA 4ALXA 2BYRA 3TLVA 3IGQA 3WTOA 4HFEA 4B5DA 5LXBA 4NPPA 5IUXA 4BQTA 4COFA 4A98A 4XHEA 4UM3P 4HFHA 4QH5A 2XQ3A 2C9TA 4ZRUA 2XQ8A 4IL9A 3UQ7A 2QC1B 2PH9A 5FJVA 4ZJTA 4Z90A 2WN9A 4PIRA 3SQ6A 2WNCA 4ZZCA 5AFNA 2Y58A 2XQ7A 3UU3A 3RIAA 3UU4A 2XNTA 3TLSA 2UZ6A 2ZJUA 2XQ5A 3EI0A 3TLUA 2W8FA 4QAAA 4UM1A 5AFHA 4HFCA 4NZBA 5J5IA 3WTMA 2BG9C 4ILAA 3EHZA 1UW6A 2XNUA 5BP0A 5AFJA 3U8LA 5KE4A 3RIFA 4BFQA 3PMZA 3PEOA 1UV6A 4EZ1A 5AFMB 5AINA 5L4EA 5HCMA 3WTLA 4AFGA 2PGZA 2ZJVA 2BJ0A 4QH4A 5AFLA 2BG9A
chains in the Genus database with same CATH superfamily
2YMDA 3JADA 5BRXA 2X00A 3UQ4A 5CFBA 5CO5A 5JMEA 4DBMA 2BYQA 2X00D 3LSVA 3JAFA 4QH1A 3RI5A 1UX2A 4ILBA 3WTIA 2BYNA 5HEGA 5HEUA 4ZZBA 2Y57A 4ZK4A 4HFBA 3RQWA 4F8HA 3U8MA 4QABA 2Y7YA 4UM3A 4A97A 3SQ9A 3WTJA 4HFIA 3RHWA 3TLTA 5HEOA 3U8KA 4FRRA 2WZYA 4WV9A 4ZK1A 4AFTA 4AFHA 4D01A 4UM3S 2YOEA 4X5TA 4UY2A 5BW2A 4HQPA 4HFDA 5L47A 5LG3A 2Y56A 4QACA 3ZKRA 3WIPA 4TWFA 3C84A 5HCJA 2XYTA 4ZR6A 4TNVA 3P4WA 2BG9E 3SIOA 2YKSA 4LMKA 5TVCA 4TWHA 5KZUA 2YN6A 4Z91A 2XQ9A 3P50A 2XQ6A 5J0ZA 5HEHA 2BR7A 4IL4A 3UU6A 5AFKA 2WNLA 2XQAA 2W8GA 2YMEA 4UXUA 4XK9A 3WTHA 3C79A 5J5HA 3ZDGA 3TLWA 2XZ5A 3JAEA 5L4HA 2XYSA 3UUBA 5AFMA 4TWDA 5J5GA 3T4MA 3U8NA 5J5FA 2WNJA 2BG9B 2BR8A 4LMJA 2XNVA 2XQ4A 3UU8A 2BYSA 4TNWA 3RQUA 4ZJSA 5SYOA 3SH1A 3U8JA 3WTKA 3EAMA 3GUAA 5HEJA 2VL0A 3UU5A 2Y54A 1I9BA 3WTNA 2XZ6A 4LMLA 2BYPA 4ILCA 4IREA 3ZDHA 4ALXA 2BYRA 3TLVA 3IGQA 3WTOA 4HFEA 4B5DA 5LXBA 4NPPA 5IUXA 4BQTA 4COFA 4A98A 4XHEA 4UM3P 4HFHA 4QH5A 2XQ3A 2C9TA 4ZRUA 2XQ8A 4IL9A 3UQ7A 2QC1B 2PH9A 5FJVA 4ZJTA 4Z90A 2WN9A 4PIRA 3SQ6A 2WNCA 4ZZCA 5AFNA 2Y58A 2XQ7A 3UU3A 3RIAA 3UU4A 2XNTA 3TLSA 2UZ6A 2ZJUA 2XQ5A 3EI0A 3TLUA 2W8FA 4QAAA 4UM1A 5AFHA 4HFCA 4NZBA 5J5IA 3WTMA 2BG9C 4ILAA 3EHZA 1UW6A 2XNUA 5BP0A 5AFJA 3U8LA 5KE4A 3RIFA 4BFQA 3PMZA 3PEOA 1UV6A 4EZ1A 5AFMB 5AINA 5L4EA 5HCMA 3WTLA 4AFGA 2PGZA 2ZJVA 2BJ0A 4QH4A 5AFLA 2BG9A
chains in the Genus database with same CATH topology
2YMDA 3JADA 5BRXA 2X00A 3UQ4A 5CFBA 5CO5A 5JMEA 4DBMA 2BYQA 2X00D 3LSVA 3JAFA 4QH1A 3RI5A 1UX2A 4ILBA 3WTIA 2BYNA 5HEGA 5HEUA 4ZZBA 2Y57A 4ZK4A 4HFBA 3RQWA 4F8HA 3U8MA 4QABA 2Y7YA 4UM3A 4A97A 3SQ9A 3WTJA 4HFIA 3RHWA 3TLTA 5HEOA 3U8KA 4FRRA 2WZYA 4WV9A 4ZK1A 4AFTA 4AFHA 4D01A 4UM3S 2YOEA 4X5TA 4UY2A 5BW2A 4HQPA 4HFDA 5L47A 5LG3A 2Y56A 4QACA 3ZKRA 3WIPA 4TWFA 3C84A 5HCJA 2XYTA 4ZR6A 4TNVA 3P4WA 2BG9E 3SIOA 2YKSA 4LMKA 5TVCA 4TWHA 5KZUA 2YN6A 4Z91A 2XQ9A 3P50A 2XQ6A 5J0ZA 5HEHA 2BR7A 4IL4A 3UU6A 5AFKA 2WNLA 2XQAA 2W8GA 2YMEA 4UXUA 4XK9A 3WTHA 3C79A 5J5HA 3ZDGA 3TLWA 2XZ5A 3JAEA 5L4HA 2XYSA 3UUBA 5AFMA 4TWDA 5J5GA 3T4MA 3U8NA 5J5FA 2WNJA 2BG9B 2BR8A 4LMJA 2XNVA 2XQ4A 3UU8A 2BYSA 4TNWA 3RQUA 4ZJSA 5SYOA 3SH1A 3U8JA 3WTKA 3EAMA 3GUAA 5HEJA 2VL0A 3UU5A 2Y54A 1I9BA 3WTNA 2XZ6A 4LMLA 2BYPA 4ILCA 4IREA 3ZDHA 4ALXA 2BYRA 3TLVA 3IGQA 3WTOA 4HFEA 4B5DA 5LXBA 4NPPA 5IUXA 4BQTA 4COFA 4A98A 4XHEA 4UM3P 4HFHA 4QH5A 2XQ3A 2C9TA 4ZRUA 2XQ8A 4IL9A 3UQ7A 2QC1B 2PH9A 5FJVA 4ZJTA 4Z90A 2WN9A 4PIRA 3SQ6A 2WNCA 4ZZCA 5AFNA 2Y58A 2XQ7A 3UU3A 3RIAA 3UU4A 2XNTA 3TLSA 2UZ6A 2ZJUA 2XQ5A 3EI0A 3TLUA 2W8FA 4QAAA 4UM1A 5AFHA 4HFCA 4NZBA 5J5IA 3WTMA 2BG9C 4ILAA 3EHZA 1UW6A 2XNUA 5BP0A 5AFJA 3U8LA 5KE4A 3RIFA 4BFQA 3PMZA 3PEOA 1UV6A 4EZ1A 5AFMB 5AINA 5L4EA 5HCMA 3WTLA 4AFGA 2PGZA 2ZJVA 2BJ0A 4QH4A 5AFLA 2BG9A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2YMD A;  3JAD A;  5BRX A;  2X00 A;  3UQ4 A;  5CFB A;  5CO5 A;  5JME A;  4DBM A;  2BYQ A;  2X00 D;  3LSV A;  3JAF A;  4QH1 A;  3RI5 A;  1UX2 A;  4ILB A;  3WTI A;  2BYN A;  5HEG A;  5HEU A;  4ZZB A;  2Y57 A;  4ZK4 A;  4HFB A;  3RQW A;  4F8H A;  3U8M A;  4QAB A;  2Y7Y A;  4UM3 A;  4A97 A;  3SQ9 A;  3WTJ A;  4HFI A;  3RHW A;  3TLT A;  5HEO A;  3U8K A;  4FRR A;  2WZY A;  4WV9 A;  4ZK1 A;  4AFT A;  4AFH A;  4D01 A;  4UM3 S;  2YOE A;  4X5T A;  4UY2 A;  5BW2 A;  4HQP A;  4HFD A;  5L47 A;  5LG3 A;  2Y56 A;  4QAC A;  3ZKR A;  3WIP A;  4TWF A;  3C84 A;  5HCJ A;  2XYT A;  4ZR6 A;  4TNV A;  3P4W A;  2BG9 E;  3SIO A;  2YKS A;  4LMK A;  5TVC A;  4TWH A;  5KZU A;  2YN6 A;  4Z91 A;  2XQ9 A;  3P50 A;  2XQ6 A;  5J0Z A;  5HEH A;  2BR7 A;  4IL4 A;  3UU6 A;  5AFK A;  2WNL A;  2XQA A;  2W8G A;  2YME A;  4UXU A;  4XK9 A;  3WTH A;  3C79 A;  5J5H A;  3ZDG A;  3TLW A;  2XZ5 A;  3JAE A;  5L4H A;  2XYS A;  3UUB A;  5AFM A;  4TWD A;  5J5G A;  3T4M A;  3U8N A;  5J5F A;  2WNJ A;  2BG9 B;  2BR8 A;  4LMJ A;  2XNV A;  2XQ4 A;  3UU8 A;  2BYS A;  4TNW A;  3RQU A;  4ZJS A;  5SYO A;  3SH1 A;  3U8J A;  3WTK A;  3EAM A;  3GUA A;  5HEJ A;  2VL0 A;  3UU5 A;  2Y54 A;  1I9B A;  3WTN A;  2XZ6 A;  4LML A;  2BYP A;  4ILC A;  4IRE A;  3ZDH A;  4ALX A;  2BYR A;  3TLV A;  3IGQ A;  3WTO A;  4HFE A;  4B5D A;  5LXB A;  4NPP A;  5IUX A;  4BQT A;  4COF A;  4A98 A;  4XHE A;  4UM3 P;  4HFH A;  4QH5 A;  2XQ3 A;  2C9T A;  4ZRU A;  2XQ8 A;  4IL9 A;  3UQ7 A;  2QC1 B;  2PH9 A;  5FJV A;  4ZJT A;  4Z90 A;  2WN9 A;  4PIR A;  3SQ6 A;  2WNC A;  4ZZC A;  5AFN A;  2Y58 A;  2XQ7 A;  3UU3 A;  3RIA A;  3UU4 A;  2XNT A;  3TLS A;  2UZ6 A;  2ZJU A;  2XQ5 A;  3EI0 A;  3TLU A;  2W8F A;  4QAA A;  4UM1 A;  5AFH A;  4HFC A;  4NZB A;  5J5I A;  3WTM A;  2BG9 C;  4ILA A;  3EHZ A;  1UW6 A;  2XNU A;  5BP0 A;  5AFJ A;  3U8L A;  5KE4 A;  3RIF A;  4BFQ A;  3PMZ A;  3PEO A;  1UV6 A;  4EZ1 A;  5AFM B;  5AIN A;  5L4E A;  5HCM A;  3WTL A;  4AFG A;  2PGZ A;  2ZJV A;  2BJ0 A;  4QH4 A;  5AFL A;  2BG9 A; 
#chains in the Genus database with same CATH topology
 2YMD A;  3JAD A;  5BRX A;  2X00 A;  3UQ4 A;  5CFB A;  5CO5 A;  5JME A;  4DBM A;  2BYQ A;  2X00 D;  3LSV A;  3JAF A;  4QH1 A;  3RI5 A;  1UX2 A;  4ILB A;  3WTI A;  2BYN A;  5HEG A;  5HEU A;  4ZZB A;  2Y57 A;  4ZK4 A;  4HFB A;  3RQW A;  4F8H A;  3U8M A;  4QAB A;  2Y7Y A;  4UM3 A;  4A97 A;  3SQ9 A;  3WTJ A;  4HFI A;  3RHW A;  3TLT A;  5HEO A;  3U8K A;  4FRR A;  2WZY A;  4WV9 A;  4ZK1 A;  4AFT A;  4AFH A;  4D01 A;  4UM3 S;  2YOE A;  4X5T A;  4UY2 A;  5BW2 A;  4HQP A;  4HFD A;  5L47 A;  5LG3 A;  2Y56 A;  4QAC A;  3ZKR A;  3WIP A;  4TWF A;  3C84 A;  5HCJ A;  2XYT A;  4ZR6 A;  4TNV A;  3P4W A;  2BG9 E;  3SIO A;  2YKS A;  4LMK A;  5TVC A;  4TWH A;  5KZU A;  2YN6 A;  4Z91 A;  2XQ9 A;  3P50 A;  2XQ6 A;  5J0Z A;  5HEH A;  2BR7 A;  4IL4 A;  3UU6 A;  5AFK A;  2WNL A;  2XQA A;  2W8G A;  2YME A;  4UXU A;  4XK9 A;  3WTH A;  3C79 A;  5J5H A;  3ZDG A;  3TLW A;  2XZ5 A;  3JAE A;  5L4H A;  2XYS A;  3UUB A;  5AFM A;  4TWD A;  5J5G A;  3T4M A;  3U8N A;  5J5F A;  2WNJ A;  2BG9 B;  2BR8 A;  4LMJ A;  2XNV A;  2XQ4 A;  3UU8 A;  2BYS A;  4TNW A;  3RQU A;  4ZJS A;  5SYO A;  3SH1 A;  3U8J A;  3WTK A;  3EAM A;  3GUA A;  5HEJ A;  2VL0 A;  3UU5 A;  2Y54 A;  1I9B A;  3WTN A;  2XZ6 A;  4LML A;  2BYP A;  4ILC A;  4IRE A;  3ZDH A;  4ALX A;  2BYR A;  3TLV A;  3IGQ A;  3WTO A;  4HFE A;  4B5D A;  5LXB A;  4NPP A;  5IUX A;  4BQT A;  4COF A;  4A98 A;  4XHE A;  4UM3 P;  4HFH A;  4QH5 A;  2XQ3 A;  2C9T A;  4ZRU A;  2XQ8 A;  4IL9 A;  3UQ7 A;  2QC1 B;  2PH9 A;  5FJV A;  4ZJT A;  4Z90 A;  2WN9 A;  4PIR A;  3SQ6 A;  2WNC A;  4ZZC A;  5AFN A;  2Y58 A;  2XQ7 A;  3UU3 A;  3RIA A;  3UU4 A;  2XNT A;  3TLS A;  2UZ6 A;  2ZJU A;  2XQ5 A;  3EI0 A;  3TLU A;  2W8F A;  4QAA A;  4UM1 A;  5AFH A;  4HFC A;  4NZB A;  5J5I A;  3WTM A;  2BG9 C;  4ILA A;  3EHZ A;  1UW6 A;  2XNU A;  5BP0 A;  5AFJ A;  3U8L A;  5KE4 A;  3RIF A;  4BFQ A;  3PMZ A;  3PEO A;  1UV6 A;  4EZ1 A;  5AFM B;  5AIN A;  5L4E A;  5HCM A;  3WTL A;  4AFG A;  2PGZ A;  2ZJV A;  2BJ0 A;  4QH4 A;  5AFL A;  2BG9 A; 
#chains in the Genus database with same CATH homology
 2YMD A;  3JAD A;  5BRX A;  2X00 A;  3UQ4 A;  5CFB A;  5CO5 A;  5JME A;  4DBM A;  2BYQ A;  2X00 D;  3LSV A;  3JAF A;  4QH1 A;  3RI5 A;  1UX2 A;  4ILB A;  3WTI A;  2BYN A;  5HEG A;  5HEU A;  4ZZB A;  2Y57 A;  4ZK4 A;  4HFB A;  3RQW A;  4F8H A;  3U8M A;  4QAB A;  2Y7Y A;  4UM3 A;  4A97 A;  3SQ9 A;  3WTJ A;  4HFI A;  3RHW A;  3TLT A;  5HEO A;  3U8K A;  4FRR A;  2WZY A;  4WV9 A;  4ZK1 A;  4AFT A;  4AFH A;  4D01 A;  4UM3 S;  2YOE A;  4X5T A;  4UY2 A;  5BW2 A;  4HQP A;  4HFD A;  5L47 A;  5LG3 A;  2Y56 A;  4QAC A;  3ZKR A;  3WIP A;  4TWF A;  3C84 A;  5HCJ A;  2XYT A;  4ZR6 A;  4TNV A;  3P4W A;  2BG9 E;  3SIO A;  2YKS A;  4LMK A;  5TVC A;  4TWH A;  5KZU A;  2YN6 A;  4Z91 A;  2XQ9 A;  3P50 A;  2XQ6 A;  5J0Z A;  5HEH A;  2BR7 A;  4IL4 A;  3UU6 A;  5AFK A;  2WNL A;  2XQA A;  2W8G A;  2YME A;  4UXU A;  4XK9 A;  3WTH A;  3C79 A;  5J5H A;  3ZDG A;  3TLW A;  2XZ5 A;  3JAE A;  5L4H A;  2XYS A;  3UUB A;  5AFM A;  4TWD A;  5J5G A;  3T4M A;  3U8N A;  5J5F A;  2WNJ A;  2BG9 B;  2BR8 A;  4LMJ A;  2XNV A;  2XQ4 A;  3UU8 A;  2BYS A;  4TNW A;  3RQU A;  4ZJS A;  5SYO A;  3SH1 A;  3U8J A;  3WTK A;  3EAM A;  3GUA A;  5HEJ A;  2VL0 A;  3UU5 A;  2Y54 A;  1I9B A;  3WTN A;  2XZ6 A;  4LML A;  2BYP A;  4ILC A;  4IRE A;  3ZDH A;  4ALX A;  2BYR A;  3TLV A;  3IGQ A;  3WTO A;  4HFE A;  4B5D A;  5LXB A;  4NPP A;  5IUX A;  4BQT A;  4COF A;  4A98 A;  4XHE A;  4UM3 P;  4HFH A;  4QH5 A;  2XQ3 A;  2C9T A;  4ZRU A;  2XQ8 A;  4IL9 A;  3UQ7 A;  2QC1 B;  2PH9 A;  5FJV A;  4ZJT A;  4Z90 A;  2WN9 A;  4PIR A;  3SQ6 A;  2WNC A;  4ZZC A;  5AFN A;  2Y58 A;  2XQ7 A;  3UU3 A;  3RIA A;  3UU4 A;  2XNT A;  3TLS A;  2UZ6 A;  2ZJU A;  2XQ5 A;  3EI0 A;  3TLU A;  2W8F A;  4QAA A;  4UM1 A;  5AFH A;  4HFC A;  4NZB A;  5J5I A;  3WTM A;  2BG9 C;  4ILA A;  3EHZ A;  1UW6 A;  2XNU A;  5BP0 A;  5AFJ A;  3U8L A;  5KE4 A;  3RIF A;  4BFQ A;  3PMZ A;  3PEO A;  1UV6 A;  4EZ1 A;  5AFM B;  5AIN A;  5L4E A;  5HCM A;  3WTL A;  4AFG A;  2PGZ A;  2ZJV A;  2BJ0 A;  4QH4 A;  5AFL A;  2BG9 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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