3U8JA

Crystal structure of the acetylcholine binding protein (achbp) from lymnaea stagnalis in complex with ns3531 (1-(pyridin-3-yl)-1,4-diazepane)
Total Genus 50
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
50
sequence length
206
structure length
206
Chain Sequence
LDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLARVVSDGEVLYMPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTTENSDDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKGR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Intersubunit bridge formation governs agonist efficacy at nicotinic acetylcholine alpha 4 beta 2 receptors: unique role of halogen bonding revealed.
pubmed doi rcsb
molecule tags Acetylcholine-binding protein/agonist
source organism Lymnaea stagnalis
molecule keywords Acetylcholine-binding protein
total genus 50
structure length 206
sequence length 206
chains with identical sequence B, C, D, E, F, G, H, I, J
ec nomenclature
pdb deposition date 2011-10-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02931 Neur_chan_LBD Neurotransmitter-gated ion-channel ligand binding domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.170.10 Mainly Beta Distorted Sandwich Acetylcholine Binding Protein; Chain: A, Neurotransmitter-gated ion-channel ligand-binding domain 3u8jA00
5HCJA 4ZK4A 5AFNA 3EI0A 4QAAA 4BQTA 5JMEA 4UM3S 2X00A 2Y54A 4TWDA 3T4MA 3WTJA 3ZDGA 4QH5A 2BG9C 3PEOA 4NZBA 4FRRA 2XQ5A 5CO5A 3TLSA 5BRXA 1UX2A 4AFHA 4LMLA 3UU6A 2YMDA 2XNTA 4WV9A 4BFQA 5HEGA 3C79A 4QH1A 4DBMA 3ZDHA 4A98A 4ZZBA 4HQPA 2WZYA 5HEOA 4ILBA 4ALXA 3RI5A 5BP0A 5LG3A 2XQ6A 4UXUA 3UQ4A 4ILAA 3LSVA 3U8NA 2Y56A 2PH9A 2XQ7A 2Y7YA 3C84A 3JAEA 4LMJA 2XQ9A 3EHZA 3UQ7A 4ZJTA 5BW2A 5J5FA 2XNVA 4HFBA 3WTNA 2XZ5A 4ZRUA 2UZ6A 4ZR6A 2YKSA 5AFKA 3RHWA 5HEUA 3TLWA 2YOEA 4UM1A 2BG9B 2QC1B 4AFGA 4COFA 5TVCA 2ZJUA 3WTHA 3U8JA 2C9TA 4TWHA 3UU5A 4XK9A 3UU4A 4D01A 4ZJSA 5AFMA 3WTIA 2XQ4A 1I9BA 3WTKA 5J0ZA 3TLUA 2WNJA 4ILCA 3P50A 2BYSA 3PMZA 4NPPA 4EZ1A 3WTLA 4IL9A 3UU8A 5AFJA 3WTMA 3IGQA 4QH4A 1UV6A 5LXBA 4HFEA 3GUAA 4TWFA 3JAFA 4Z90A 3WTOA 4ZK1A 5L4HA 3RQWA 5AINA 5HEJA 4UM3A 3U8LA 5SYOA 3SIOA 3WIPA 5KE4A 2XYSA 3EAMA 5HEHA 2BYRA 4HFHA 4LMKA 2BR8A 4Z91A 4ZZCA 4UY2A 4QACA 2VL0A 3TLVA 2XQAA 4XHEA 3RIAA 5J5IA 4AFTA 5KZUA 3SH1A 3JADA 3SQ9A 5IUXA 2BJ0A 3UU3A 2XQ8A 5J5HA 4PIRA 2WNLA 2BYQA 3U8KA 2ZJVA 2BG9E 5FJVA 3SQ6A 2W8FA 4HFDA 2WNCA 2XYTA 2X00D 2BR7A 3ZKRA 5HCMA 2WN9A 2W8GA 5AFHA 5J5GA 2XQ3A 2Y58A 2PGZA 2YN6A 4HFCA 4F8HA 3TLTA 4HFIA 5L47A 5AFLA 2YMEA 3RIFA 5AFMB 4IL4A 3U8MA 4UM3P 4A97A 2XZ6A 4X5TA 3P4WA 4TNWA 4TNVA 3UUBA 2BYPA 4IREA 2XNUA 2Y57A 2BYNA 5CFBA 2BG9A 5L4EA 1UW6A 4QABA 4B5DA 3RQUA
chains in the Genus database with same CATH superfamily
5HCJA 4ZK4A 5AFNA 3EI0A 4QAAA 4BQTA 5JMEA 4UM3S 2X00A 2Y54A 4TWDA 3T4MA 3WTJA 3ZDGA 4QH5A 2BG9C 3PEOA 4NZBA 4FRRA 2XQ5A 5CO5A 3TLSA 5BRXA 1UX2A 4AFHA 4LMLA 3UU6A 2YMDA 2XNTA 4WV9A 4BFQA 5HEGA 3C79A 4QH1A 4DBMA 3ZDHA 4A98A 4ZZBA 4HQPA 2WZYA 5HEOA 4ILBA 4ALXA 3RI5A 5BP0A 5LG3A 2XQ6A 4UXUA 3UQ4A 4ILAA 3LSVA 3U8NA 2Y56A 2PH9A 2XQ7A 2Y7YA 3C84A 3JAEA 4LMJA 2XQ9A 3EHZA 3UQ7A 4ZJTA 5BW2A 5J5FA 2XNVA 4HFBA 3WTNA 2XZ5A 4ZRUA 2UZ6A 4ZR6A 2YKSA 5AFKA 3RHWA 5HEUA 3TLWA 2YOEA 4UM1A 2BG9B 2QC1B 4AFGA 4COFA 5TVCA 2ZJUA 3WTHA 3U8JA 2C9TA 4TWHA 3UU5A 4XK9A 3UU4A 4D01A 4ZJSA 5AFMA 3WTIA 2XQ4A 1I9BA 3WTKA 5J0ZA 3TLUA 2WNJA 4ILCA 3P50A 2BYSA 3PMZA 4NPPA 4EZ1A 3WTLA 4IL9A 3UU8A 5AFJA 3WTMA 3IGQA 4QH4A 1UV6A 5LXBA 4HFEA 3GUAA 4TWFA 3JAFA 4Z90A 3WTOA 4ZK1A 5L4HA 3RQWA 5AINA 5HEJA 4UM3A 3U8LA 5SYOA 3SIOA 3WIPA 5KE4A 2XYSA 3EAMA 5HEHA 2BYRA 4HFHA 4LMKA 2BR8A 4Z91A 4ZZCA 4UY2A 4QACA 2VL0A 3TLVA 2XQAA 4XHEA 3RIAA 5J5IA 4AFTA 5KZUA 3SH1A 3JADA 3SQ9A 5IUXA 2BJ0A 3UU3A 2XQ8A 5J5HA 4PIRA 2WNLA 2BYQA 3U8KA 2ZJVA 2BG9E 5FJVA 3SQ6A 2W8FA 4HFDA 2WNCA 2XYTA 2X00D 2BR7A 3ZKRA 5HCMA 2WN9A 2W8GA 5AFHA 5J5GA 2XQ3A 2Y58A 2PGZA 2YN6A 4HFCA 4F8HA 3TLTA 4HFIA 5L47A 5AFLA 2YMEA 3RIFA 5AFMB 4IL4A 3U8MA 4UM3P 4A97A 2XZ6A 4X5TA 3P4WA 4TNWA 4TNVA 3UUBA 2BYPA 4IREA 2XNUA 2Y57A 2BYNA 5CFBA 2BG9A 5L4EA 1UW6A 4QABA 4B5DA 3RQUA
chains in the Genus database with same CATH topology
5HCJA 4ZK4A 5AFNA 3EI0A 4QAAA 4BQTA 5JMEA 4UM3S 2X00A 2Y54A 4TWDA 3T4MA 3WTJA 3ZDGA 4QH5A 2BG9C 3PEOA 4NZBA 4FRRA 2XQ5A 5CO5A 3TLSA 5BRXA 1UX2A 4AFHA 4LMLA 3UU6A 2YMDA 2XNTA 4WV9A 4BFQA 5HEGA 3C79A 4QH1A 4DBMA 3ZDHA 4A98A 4ZZBA 4HQPA 2WZYA 5HEOA 4ILBA 4ALXA 3RI5A 5BP0A 5LG3A 2XQ6A 4UXUA 3UQ4A 4ILAA 3LSVA 3U8NA 2Y56A 2PH9A 2XQ7A 2Y7YA 3C84A 3JAEA 4LMJA 2XQ9A 3EHZA 3UQ7A 4ZJTA 5BW2A 5J5FA 2XNVA 4HFBA 3WTNA 2XZ5A 4ZRUA 2UZ6A 4ZR6A 2YKSA 5AFKA 3RHWA 5HEUA 3TLWA 2YOEA 4UM1A 2BG9B 2QC1B 4AFGA 4COFA 5TVCA 2ZJUA 3WTHA 3U8JA 2C9TA 4TWHA 3UU5A 4XK9A 3UU4A 4D01A 4ZJSA 5AFMA 3WTIA 2XQ4A 1I9BA 3WTKA 5J0ZA 3TLUA 2WNJA 4ILCA 3P50A 2BYSA 3PMZA 4NPPA 4EZ1A 3WTLA 4IL9A 3UU8A 5AFJA 3WTMA 3IGQA 4QH4A 1UV6A 5LXBA 4HFEA 3GUAA 4TWFA 3JAFA 4Z90A 3WTOA 4ZK1A 5L4HA 3RQWA 5AINA 5HEJA 4UM3A 3U8LA 5SYOA 3SIOA 3WIPA 5KE4A 2XYSA 3EAMA 5HEHA 2BYRA 4HFHA 4LMKA 2BR8A 4Z91A 4ZZCA 4UY2A 4QACA 2VL0A 3TLVA 2XQAA 4XHEA 3RIAA 5J5IA 4AFTA 5KZUA 3SH1A 3JADA 3SQ9A 5IUXA 2BJ0A 3UU3A 2XQ8A 5J5HA 4PIRA 2WNLA 2BYQA 3U8KA 2ZJVA 2BG9E 5FJVA 3SQ6A 2W8FA 4HFDA 2WNCA 2XYTA 2X00D 2BR7A 3ZKRA 5HCMA 2WN9A 2W8GA 5AFHA 5J5GA 2XQ3A 2Y58A 2PGZA 2YN6A 4HFCA 4F8HA 3TLTA 4HFIA 5L47A 5AFLA 2YMEA 3RIFA 5AFMB 4IL4A 3U8MA 4UM3P 4A97A 2XZ6A 4X5TA 3P4WA 4TNWA 4TNVA 3UUBA 2BYPA 4IREA 2XNUA 2Y57A 2BYNA 5CFBA 2BG9A 5L4EA 1UW6A 4QABA 4B5DA 3RQUA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5HCJ A;  4ZK4 A;  5AFN A;  3EI0 A;  4QAA A;  4BQT A;  5JME A;  4UM3 S;  2X00 A;  2Y54 A;  4TWD A;  3T4M A;  3WTJ A;  3ZDG A;  4QH5 A;  2BG9 C;  3PEO A;  4NZB A;  4FRR A;  2XQ5 A;  5CO5 A;  3TLS A;  5BRX A;  1UX2 A;  4AFH A;  4LML A;  3UU6 A;  2YMD A;  2XNT A;  4WV9 A;  4BFQ A;  5HEG A;  3C79 A;  4QH1 A;  4DBM A;  3ZDH A;  4A98 A;  4ZZB A;  4HQP A;  2WZY A;  5HEO A;  4ILB A;  4ALX A;  3RI5 A;  5BP0 A;  5LG3 A;  2XQ6 A;  4UXU A;  3UQ4 A;  4ILA A;  3LSV A;  3U8N A;  2Y56 A;  2PH9 A;  2XQ7 A;  2Y7Y A;  3C84 A;  3JAE A;  4LMJ A;  2XQ9 A;  3EHZ A;  3UQ7 A;  4ZJT A;  5BW2 A;  5J5F A;  2XNV A;  4HFB A;  3WTN A;  2XZ5 A;  4ZRU A;  2UZ6 A;  4ZR6 A;  2YKS A;  5AFK A;  3RHW A;  5HEU A;  3TLW A;  2YOE A;  4UM1 A;  2BG9 B;  2QC1 B;  4AFG A;  4COF A;  5TVC A;  2ZJU A;  3WTH A;  3U8J A;  2C9T A;  4TWH A;  3UU5 A;  4XK9 A;  3UU4 A;  4D01 A;  4ZJS A;  5AFM A;  3WTI A;  2XQ4 A;  1I9B A;  3WTK A;  5J0Z A;  3TLU A;  2WNJ A;  4ILC A;  3P50 A;  2BYS A;  3PMZ A;  4NPP A;  4EZ1 A;  3WTL A;  4IL9 A;  3UU8 A;  5AFJ A;  3WTM A;  3IGQ A;  4QH4 A;  1UV6 A;  5LXB A;  4HFE A;  3GUA A;  4TWF A;  3JAF A;  4Z90 A;  3WTO A;  4ZK1 A;  5L4H A;  3RQW A;  5AIN A;  5HEJ A;  4UM3 A;  3U8L A;  5SYO A;  3SIO A;  3WIP A;  5KE4 A;  2XYS A;  3EAM A;  5HEH A;  2BYR A;  4HFH A;  4LMK A;  2BR8 A;  4Z91 A;  4ZZC A;  4UY2 A;  4QAC A;  2VL0 A;  3TLV A;  2XQA A;  4XHE A;  3RIA A;  5J5I A;  4AFT A;  5KZU A;  3SH1 A;  3JAD A;  3SQ9 A;  5IUX A;  2BJ0 A;  3UU3 A;  2XQ8 A;  5J5H A;  4PIR A;  2WNL A;  2BYQ A;  3U8K A;  2ZJV A;  2BG9 E;  5FJV A;  3SQ6 A;  2W8F A;  4HFD A;  2WNC A;  2XYT A;  2X00 D;  2BR7 A;  3ZKR A;  5HCM A;  2WN9 A;  2W8G A;  5AFH A;  5J5G A;  2XQ3 A;  2Y58 A;  2PGZ A;  2YN6 A;  4HFC A;  4F8H A;  3TLT A;  4HFI A;  5L47 A;  5AFL A;  2YME A;  3RIF A;  5AFM B;  4IL4 A;  3U8M A;  4UM3 P;  4A97 A;  2XZ6 A;  4X5T A;  3P4W A;  4TNW A;  4TNV A;  3UUB A;  2BYP A;  4IRE A;  2XNU A;  2Y57 A;  2BYN A;  5CFB A;  2BG9 A;  5L4E A;  1UW6 A;  4QAB A;  4B5D A;  3RQU A; 
#chains in the Genus database with same CATH topology
 5HCJ A;  4ZK4 A;  5AFN A;  3EI0 A;  4QAA A;  4BQT A;  5JME A;  4UM3 S;  2X00 A;  2Y54 A;  4TWD A;  3T4M A;  3WTJ A;  3ZDG A;  4QH5 A;  2BG9 C;  3PEO A;  4NZB A;  4FRR A;  2XQ5 A;  5CO5 A;  3TLS A;  5BRX A;  1UX2 A;  4AFH A;  4LML A;  3UU6 A;  2YMD A;  2XNT A;  4WV9 A;  4BFQ A;  5HEG A;  3C79 A;  4QH1 A;  4DBM A;  3ZDH A;  4A98 A;  4ZZB A;  4HQP A;  2WZY A;  5HEO A;  4ILB A;  4ALX A;  3RI5 A;  5BP0 A;  5LG3 A;  2XQ6 A;  4UXU A;  3UQ4 A;  4ILA A;  3LSV A;  3U8N A;  2Y56 A;  2PH9 A;  2XQ7 A;  2Y7Y A;  3C84 A;  3JAE A;  4LMJ A;  2XQ9 A;  3EHZ A;  3UQ7 A;  4ZJT A;  5BW2 A;  5J5F A;  2XNV A;  4HFB A;  3WTN A;  2XZ5 A;  4ZRU A;  2UZ6 A;  4ZR6 A;  2YKS A;  5AFK A;  3RHW A;  5HEU A;  3TLW A;  2YOE A;  4UM1 A;  2BG9 B;  2QC1 B;  4AFG A;  4COF A;  5TVC A;  2ZJU A;  3WTH A;  3U8J A;  2C9T A;  4TWH A;  3UU5 A;  4XK9 A;  3UU4 A;  4D01 A;  4ZJS A;  5AFM A;  3WTI A;  2XQ4 A;  1I9B A;  3WTK A;  5J0Z A;  3TLU A;  2WNJ A;  4ILC A;  3P50 A;  2BYS A;  3PMZ A;  4NPP A;  4EZ1 A;  3WTL A;  4IL9 A;  3UU8 A;  5AFJ A;  3WTM A;  3IGQ A;  4QH4 A;  1UV6 A;  5LXB A;  4HFE A;  3GUA A;  4TWF A;  3JAF A;  4Z90 A;  3WTO A;  4ZK1 A;  5L4H A;  3RQW A;  5AIN A;  5HEJ A;  4UM3 A;  3U8L A;  5SYO A;  3SIO A;  3WIP A;  5KE4 A;  2XYS A;  3EAM A;  5HEH A;  2BYR A;  4HFH A;  4LMK A;  2BR8 A;  4Z91 A;  4ZZC A;  4UY2 A;  4QAC A;  2VL0 A;  3TLV A;  2XQA A;  4XHE A;  3RIA A;  5J5I A;  4AFT A;  5KZU A;  3SH1 A;  3JAD A;  3SQ9 A;  5IUX A;  2BJ0 A;  3UU3 A;  2XQ8 A;  5J5H A;  4PIR A;  2WNL A;  2BYQ A;  3U8K A;  2ZJV A;  2BG9 E;  5FJV A;  3SQ6 A;  2W8F A;  4HFD A;  2WNC A;  2XYT A;  2X00 D;  2BR7 A;  3ZKR A;  5HCM A;  2WN9 A;  2W8G A;  5AFH A;  5J5G A;  2XQ3 A;  2Y58 A;  2PGZ A;  2YN6 A;  4HFC A;  4F8H A;  3TLT A;  4HFI A;  5L47 A;  5AFL A;  2YME A;  3RIF A;  5AFM B;  4IL4 A;  3U8M A;  4UM3 P;  4A97 A;  2XZ6 A;  4X5T A;  3P4W A;  4TNW A;  4TNV A;  3UUB A;  2BYP A;  4IRE A;  2XNU A;  2Y57 A;  2BYN A;  5CFB A;  2BG9 A;  5L4E A;  1UW6 A;  4QAB A;  4B5D A;  3RQU A; 
#chains in the Genus database with same CATH homology
 5HCJ A;  4ZK4 A;  5AFN A;  3EI0 A;  4QAA A;  4BQT A;  5JME A;  4UM3 S;  2X00 A;  2Y54 A;  4TWD A;  3T4M A;  3WTJ A;  3ZDG A;  4QH5 A;  2BG9 C;  3PEO A;  4NZB A;  4FRR A;  2XQ5 A;  5CO5 A;  3TLS A;  5BRX A;  1UX2 A;  4AFH A;  4LML A;  3UU6 A;  2YMD A;  2XNT A;  4WV9 A;  4BFQ A;  5HEG A;  3C79 A;  4QH1 A;  4DBM A;  3ZDH A;  4A98 A;  4ZZB A;  4HQP A;  2WZY A;  5HEO A;  4ILB A;  4ALX A;  3RI5 A;  5BP0 A;  5LG3 A;  2XQ6 A;  4UXU A;  3UQ4 A;  4ILA A;  3LSV A;  3U8N A;  2Y56 A;  2PH9 A;  2XQ7 A;  2Y7Y A;  3C84 A;  3JAE A;  4LMJ A;  2XQ9 A;  3EHZ A;  3UQ7 A;  4ZJT A;  5BW2 A;  5J5F A;  2XNV A;  4HFB A;  3WTN A;  2XZ5 A;  4ZRU A;  2UZ6 A;  4ZR6 A;  2YKS A;  5AFK A;  3RHW A;  5HEU A;  3TLW A;  2YOE A;  4UM1 A;  2BG9 B;  2QC1 B;  4AFG A;  4COF A;  5TVC A;  2ZJU A;  3WTH A;  3U8J A;  2C9T A;  4TWH A;  3UU5 A;  4XK9 A;  3UU4 A;  4D01 A;  4ZJS A;  5AFM A;  3WTI A;  2XQ4 A;  1I9B A;  3WTK A;  5J0Z A;  3TLU A;  2WNJ A;  4ILC A;  3P50 A;  2BYS A;  3PMZ A;  4NPP A;  4EZ1 A;  3WTL A;  4IL9 A;  3UU8 A;  5AFJ A;  3WTM A;  3IGQ A;  4QH4 A;  1UV6 A;  5LXB A;  4HFE A;  3GUA A;  4TWF A;  3JAF A;  4Z90 A;  3WTO A;  4ZK1 A;  5L4H A;  3RQW A;  5AIN A;  5HEJ A;  4UM3 A;  3U8L A;  5SYO A;  3SIO A;  3WIP A;  5KE4 A;  2XYS A;  3EAM A;  5HEH A;  2BYR A;  4HFH A;  4LMK A;  2BR8 A;  4Z91 A;  4ZZC A;  4UY2 A;  4QAC A;  2VL0 A;  3TLV A;  2XQA A;  4XHE A;  3RIA A;  5J5I A;  4AFT A;  5KZU A;  3SH1 A;  3JAD A;  3SQ9 A;  5IUX A;  2BJ0 A;  3UU3 A;  2XQ8 A;  5J5H A;  4PIR A;  2WNL A;  2BYQ A;  3U8K A;  2ZJV A;  2BG9 E;  5FJV A;  3SQ6 A;  2W8F A;  4HFD A;  2WNC A;  2XYT A;  2X00 D;  2BR7 A;  3ZKR A;  5HCM A;  2WN9 A;  2W8G A;  5AFH A;  5J5G A;  2XQ3 A;  2Y58 A;  2PGZ A;  2YN6 A;  4HFC A;  4F8H A;  3TLT A;  4HFI A;  5L47 A;  5AFL A;  2YME A;  3RIF A;  5AFM B;  4IL4 A;  3U8M A;  4UM3 P;  4A97 A;  2XZ6 A;  4X5T A;  3P4W A;  4TNW A;  4TNV A;  3UUB A;  2BYP A;  4IRE A;  2XNU A;  2Y57 A;  2BYN A;  5CFB A;  2BG9 A;  5L4E A;  1UW6 A;  4QAB A;  4B5D A;  3RQU A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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