3U8J | Genus

Total Genus 50

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	50
sequence length	206
structure length	206
Chain Sequence	LDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLARVVSDGEVLYMPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTTENSDDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKGR

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

molecule tags	Acetylcholine-binding protein/agonist
source organism	Lymnaea stagnalis
publication title	Intersubunit bridge formation governs agonist efficacy at nicotinic acetylcholine alpha 4 beta 2 receptors: unique role of halogen bonding revealed. pubmed doi rcsb
molecule keywords	Acetylcholine-binding protein
total genus	50
structure length	206
sequence length	206
chains with identical sequence	B, C, D, E, F, G, H, I, J
ec nomenclature
pdb deposition date	2011-10-17

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF02931	Neur_chan_LBD	Neurotransmitter-gated ion-channel ligand binding domain

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
2.70.170.10	Mainly Beta	Distorted Sandwich	Acetylcholine Binding Protein; Chain: A,	Neurotransmitter-gated ion-channel ligand-binding domain	3u8jA00

3EI0A 5KE4A 5FJVA 4XK9A 4ZZBA 2BG9A 4HQPA 2XQ6A 4UM1A 3UU3A 2Y58A 4BFQA 4HFCA 3UU4A 4X5TA 3ZDHA 2X00A 4UXUA 3UQ7A 2WNJA 5AFJA 4IREA 3WTIA 4ALXA 5J0ZA 3EAMA 3WTMA 3RI5A 3SH1A 4COFA 4EZ1A 3RIAA 2PH9A 5HEHA 5BRXA 3SQ9A 5AFLA 5J5HA 1UW6A 3U8MA 4AFGA 4UM3S 2XNUA 3RQWA 4F8HA 3RHWA 5BW2A 2XQAA 4ILCA 3GUAA 4FRRA 3WTNA 2WNLA 5L47A 2Y56A 2YOEA 5LG3A 1UV6A 4QAAA 3TLTA 2XQ3A 4ZK1A 2ZJUA 2XQ5A 4A98A 2BG9B 5CFBA 4IL4A 3UUBA 2YMEA 2QC1B 4HFEA 4NPPA 3U8LA 3UU5A 4IL9A 3WTOA 2WZYA 4HFIA 4ZJSA 2BG9E 2W8GA 4PIRA 5HEOA 3WTLA 2BYQA 2XQ7A 5AFMA 2Y57A 1UX2A 3WIPA 4ZR6A 5AINA 5JMEA 4XHEA 5TVCA 2XNTA 1I9BA 4D01A 4LMJA 3SQ6A 2BG9C 2BYNA 2BYRA 4QACA 2VL0A 5J5IA 2XQ9A 3ZKRA 4Z91A 4ZK4A 4HFDA 4ZZCA 3UU8A 2W8FA 4QH1A 4WV9A 4Z90A 3U8NA 2ZJVA 3ZDGA 4NZBA 5HEUA 3U8KA 4LMKA 4TNWA 3IGQA 3RIFA 4ILBA 3TLUA 4UY2A 3WTJA 5AFMB 2PGZA 4TWFA 4TWHA 2XQ4A 4HFHA 2XYSA 2BYSA 5HCJA 2YKSA 3LSVA 2BR7A 3TLSA 3WTKA 2XQ8A 3UQ4A 5KZUA 3U8JA 3EHZA 4QH4A 3TLVA 2XYTA 4B5DA 3T4MA 4TWDA 2Y7YA 5BP0A 4UM3P 4AFHA 3JAFA 3JADA 3SIOA 5HCMA 5IUXA 5HEJA 2UZ6A 3C79A 3RQUA 3UU6A 5CO5A 5J5FA 4QABA 3JAEA 4DBMA 4BQTA 4HFBA 5SYOA 4LMLA 2BYPA 3P50A 4ZRUA 3P4WA 3TLWA 2YMDA 5L4EA 2WNCA 2XNVA 5J5GA 2X00D 5LXBA 2XZ6A 5HEGA 2C9TA 3PMZA 4ILAA 4QH5A 2BJ0A 2WN9A 4TNVA 5AFHA 3C84A 2XZ5A 3PEOA 4A97A 5AFKA 4UM3A 2BR8A 2Y54A 5L4HA 3WTHA 5AFNA 2YN6A 4AFTA 4ZJTA
chains in the Genus database with same CATH superfamily

#chains in the Genus database with same CATH superfamily
 3EI0 A;  5KE4 A;  5FJV A;  4XK9 A;  4ZZB A;  2BG9 A;  4HQP A;  2XQ6 A;  4UM1 A;  3UU3 A;  2Y58 A;  4BFQ A;  4HFC A;  3UU4 A;  4X5T A;  3ZDH A;  2X00 A;  4UXU A;  3UQ7 A;  2WNJ A;  5AFJ A;  4IRE A;  3WTI A;  4ALX A;  5J0Z A;  3EAM A;  3WTM A;  3RI5 A;  3SH1 A;  4COF A;  4EZ1 A;  3RIA A;  2PH9 A;  5HEH A;  5BRX A;  3SQ9 A;  5AFL A;  5J5H A;  1UW6 A;  3U8M A;  4AFG A;  4UM3 S;  2XNU A;  3RQW A;  4F8H A;  3RHW A;  5BW2 A;  2XQA A;  4ILC A;  3GUA A;  4FRR A;  3WTN A;  2WNL A;  5L47 A;  2Y56 A;  2YOE A;  5LG3 A;  1UV6 A;  4QAA A;  3TLT A;  2XQ3 A;  4ZK1 A;  2ZJU A;  2XQ5 A;  4A98 A;  2BG9 B;  5CFB A;  4IL4 A;  3UUB A;  2YME A;  2QC1 B;  4HFE A;  4NPP A;  3U8L A;  3UU5 A;  4IL9 A;  3WTO A;  2WZY A;  4HFI A;  4ZJS A;  2BG9 E;  2W8G A;  4PIR A;  5HEO A;  3WTL A;  2BYQ A;  2XQ7 A;  5AFM A;  2Y57 A;  1UX2 A;  3WIP A;  4ZR6 A;  5AIN A;  5JME A;  4XHE A;  5TVC A;  2XNT A;  1I9B A;  4D01 A;  4LMJ A;  3SQ6 A;  2BG9 C;  2BYN A;  2BYR A;  4QAC A;  2VL0 A;  5J5I A;  2XQ9 A;  3ZKR A;  4Z91 A;  4ZK4 A;  4HFD A;  4ZZC A;  3UU8 A;  2W8F A;  4QH1 A;  4WV9 A;  4Z90 A;  3U8N A;  2ZJV A;  3ZDG A;  4NZB A;  5HEU A;  3U8K A;  4LMK A;  4TNW A;  3IGQ A;  3RIF A;  4ILB A;  3TLU A;  4UY2 A;  3WTJ A;  5AFM B;  2PGZ A;  4TWF A;  4TWH A;  2XQ4 A;  4HFH A;  2XYS A;  2BYS A;  5HCJ A;  2YKS A;  3LSV A;  2BR7 A;  3TLS A;  3WTK A;  2XQ8 A;  3UQ4 A;  5KZU A;  3U8J A;  3EHZ A;  4QH4 A;  3TLV A;  2XYT A;  4B5D A;  3T4M A;  4TWD A;  2Y7Y A;  5BP0 A;  4UM3 P;  4AFH A;  3JAF A;  3JAD A;  3SIO A;  5HCM A;  5IUX A;  5HEJ A;  2UZ6 A;  3C79 A;  3RQU A;  3UU6 A;  5CO5 A;  5J5F A;  4QAB A;  3JAE A;  4DBM A;  4BQT A;  4HFB A;  5SYO A;  4LML A;  2BYP A;  3P50 A;  4ZRU A;  3P4W A;  3TLW A;  2YMD A;  5L4E A;  2WNC A;  2XNV A;  5J5G A;  2X00 D;  5LXB A;  2XZ6 A;  5HEG A;  2C9T A;  3PMZ A;  4ILA A;  4QH5 A;  2BJ0 A;  2WN9 A;  4TNV A;  5AFH A;  3C84 A;  2XZ5 A;  3PEO A;  4A97 A;  5AFK A;  4UM3 A;  2BR8 A;  2Y54 A;  5L4H A;  3WTH A;  5AFN A;  2YN6 A;  4AFT A;  4ZJT A; 
#chains in the Genus database with same CATH topology
 3EI0 A;  5KE4 A;  5FJV A;  4XK9 A;  4ZZB A;  2BG9 A;  4HQP A;  2XQ6 A;  4UM1 A;  3UU3 A;  2Y58 A;  4BFQ A;  4HFC A;  3UU4 A;  4X5T A;  3ZDH A;  2X00 A;  4UXU A;  3UQ7 A;  2WNJ A;  5AFJ A;  4IRE A;  3WTI A;  4ALX A;  5J0Z A;  3EAM A;  3WTM A;  3RI5 A;  3SH1 A;  4COF A;  4EZ1 A;  3RIA A;  2PH9 A;  5HEH A;  5BRX A;  3SQ9 A;  5AFL A;  5J5H A;  1UW6 A;  3U8M A;  4AFG A;  4UM3 S;  2XNU A;  3RQW A;  4F8H A;  3RHW A;  5BW2 A;  2XQA A;  4ILC A;  3GUA A;  4FRR A;  3WTN A;  2WNL A;  5L47 A;  2Y56 A;  2YOE A;  5LG3 A;  1UV6 A;  4QAA A;  3TLT A;  2XQ3 A;  4ZK1 A;  2ZJU A;  2XQ5 A;  4A98 A;  2BG9 B;  5CFB A;  4IL4 A;  3UUB A;  2YME A;  2QC1 B;  4HFE A;  4NPP A;  3U8L A;  3UU5 A;  4IL9 A;  3WTO A;  2WZY A;  4HFI A;  4ZJS A;  2BG9 E;  2W8G A;  4PIR A;  5HEO A;  3WTL A;  2BYQ A;  2XQ7 A;  5AFM A;  2Y57 A;  1UX2 A;  3WIP A;  4ZR6 A;  5AIN A;  5JME A;  4XHE A;  5TVC A;  2XNT A;  1I9B A;  4D01 A;  4LMJ A;  3SQ6 A;  2BG9 C;  2BYN A;  2BYR A;  4QAC A;  2VL0 A;  5J5I A;  2XQ9 A;  3ZKR A;  4Z91 A;  4ZK4 A;  4HFD A;  4ZZC A;  3UU8 A;  2W8F A;  4QH1 A;  4WV9 A;  4Z90 A;  3U8N A;  2ZJV A;  3ZDG A;  4NZB A;  5HEU A;  3U8K A;  4LMK A;  4TNW A;  3IGQ A;  3RIF A;  4ILB A;  3TLU A;  4UY2 A;  3WTJ A;  5AFM B;  2PGZ A;  4TWF A;  4TWH A;  2XQ4 A;  4HFH A;  2XYS A;  2BYS A;  5HCJ A;  2YKS A;  3LSV A;  2BR7 A;  3TLS A;  3WTK A;  2XQ8 A;  3UQ4 A;  5KZU A;  3U8J A;  3EHZ A;  4QH4 A;  3TLV A;  2XYT A;  4B5D A;  3T4M A;  4TWD A;  2Y7Y A;  5BP0 A;  4UM3 P;  4AFH A;  3JAF A;  3JAD A;  3SIO A;  5HCM A;  5IUX A;  5HEJ A;  2UZ6 A;  3C79 A;  3RQU A;  3UU6 A;  5CO5 A;  5J5F A;  4QAB A;  3JAE A;  4DBM A;  4BQT A;  4HFB A;  5SYO A;  4LML A;  2BYP A;  3P50 A;  4ZRU A;  3P4W A;  3TLW A;  2YMD A;  5L4E A;  2WNC A;  2XNV A;  5J5G A;  2X00 D;  5LXB A;  2XZ6 A;  5HEG A;  2C9T A;  3PMZ A;  4ILA A;  4QH5 A;  2BJ0 A;  2WN9 A;  4TNV A;  5AFH A;  3C84 A;  2XZ5 A;  3PEO A;  4A97 A;  5AFK A;  4UM3 A;  2BR8 A;  2Y54 A;  5L4H A;  3WTH A;  5AFN A;  2YN6 A;  4AFT A;  4ZJT A; 
#chains in the Genus database with same CATH homology
 3EI0 A;  5KE4 A;  5FJV A;  4XK9 A;  4ZZB A;  2BG9 A;  4HQP A;  2XQ6 A;  4UM1 A;  3UU3 A;  2Y58 A;  4BFQ A;  4HFC A;  3UU4 A;  4X5T A;  3ZDH A;  2X00 A;  4UXU A;  3UQ7 A;  2WNJ A;  5AFJ A;  4IRE A;  3WTI A;  4ALX A;  5J0Z A;  3EAM A;  3WTM A;  3RI5 A;  3SH1 A;  4COF A;  4EZ1 A;  3RIA A;  2PH9 A;  5HEH A;  5BRX A;  3SQ9 A;  5AFL A;  5J5H A;  1UW6 A;  3U8M A;  4AFG A;  4UM3 S;  2XNU A;  3RQW A;  4F8H A;  3RHW A;  5BW2 A;  2XQA A;  4ILC A;  3GUA A;  4FRR A;  3WTN A;  2WNL A;  5L47 A;  2Y56 A;  2YOE A;  5LG3 A;  1UV6 A;  4QAA A;  3TLT A;  2XQ3 A;  4ZK1 A;  2ZJU A;  2XQ5 A;  4A98 A;  2BG9 B;  5CFB A;  4IL4 A;  3UUB A;  2YME A;  2QC1 B;  4HFE A;  4NPP A;  3U8L A;  3UU5 A;  4IL9 A;  3WTO A;  2WZY A;  4HFI A;  4ZJS A;  2BG9 E;  2W8G A;  4PIR A;  5HEO A;  3WTL A;  2BYQ A;  2XQ7 A;  5AFM A;  2Y57 A;  1UX2 A;  3WIP A;  4ZR6 A;  5AIN A;  5JME A;  4XHE A;  5TVC A;  2XNT A;  1I9B A;  4D01 A;  4LMJ A;  3SQ6 A;  2BG9 C;  2BYN A;  2BYR A;  4QAC A;  2VL0 A;  5J5I A;  2XQ9 A;  3ZKR A;  4Z91 A;  4ZK4 A;  4HFD A;  4ZZC A;  3UU8 A;  2W8F A;  4QH1 A;  4WV9 A;  4Z90 A;  3U8N A;  2ZJV A;  3ZDG A;  4NZB A;  5HEU A;  3U8K A;  4LMK A;  4TNW A;  3IGQ A;  3RIF A;  4ILB A;  3TLU A;  4UY2 A;  3WTJ A;  5AFM B;  2PGZ A;  4TWF A;  4TWH A;  2XQ4 A;  4HFH A;  2XYS A;  2BYS A;  5HCJ A;  2YKS A;  3LSV A;  2BR7 A;  3TLS A;  3WTK A;  2XQ8 A;  3UQ4 A;  5KZU A;  3U8J A;  3EHZ A;  4QH4 A;  3TLV A;  2XYT A;  4B5D A;  3T4M A;  4TWD A;  2Y7Y A;  5BP0 A;  4UM3 P;  4AFH A;  3JAF A;  3JAD A;  3SIO A;  5HCM A;  5IUX A;  5HEJ A;  2UZ6 A;  3C79 A;  3RQU A;  3UU6 A;  5CO5 A;  5J5F A;  4QAB A;  3JAE A;  4DBM A;  4BQT A;  4HFB A;  5SYO A;  4LML A;  2BYP A;  3P50 A;  4ZRU A;  3P4W A;  3TLW A;  2YMD A;  5L4E A;  2WNC A;  2XNV A;  5J5G A;  2X00 D;  5LXB A;  2XZ6 A;  5HEG A;  2C9T A;  3PMZ A;  4ILA A;  4QH5 A;  2BJ0 A;  2WN9 A;  4TNV A;  5AFH A;  3C84 A;  2XZ5 A;  3PEO A;  4A97 A;  5AFK A;  4UM3 A;  2BR8 A;  2Y54 A;  5L4H A;  3WTH A;  5AFN A;  2YN6 A;  4AFT A;  4ZJT A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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3U8JA

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations