3U8KA

Crystal structure of the acetylcholine binding protein (achbp) from lymnaea stagnalis in complex with ns3573 (1-(5-ethoxypyridin-3-yl)-1,4-diazepane)
Total Genus 49
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
49
sequence length
209
structure length
209
Chain Sequence
LDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLARVVSDGEVLYMPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTTENSDDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKGRSEI
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Intersubunit bridge formation governs agonist efficacy at nicotinic acetylcholine alpha 4 beta 2 receptors: unique role of halogen bonding revealed.
pubmed doi rcsb
molecule tags Acetylcholine-binding protein/agonist
source organism Lymnaea stagnalis
molecule keywords Acetylcholine-binding protein
total genus 49
structure length 209
sequence length 209
chains with identical sequence B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T
ec nomenclature
pdb deposition date 2011-10-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02931 Neur_chan_LBD Neurotransmitter-gated ion-channel ligand binding domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.170.10 Mainly Beta Distorted Sandwich Acetylcholine Binding Protein; Chain: A, Neurotransmitter-gated ion-channel ligand-binding domain 3u8kA00
2PH9A 2BYRA 3RIAA 4EZ1A 4ZZBA 2BYSA 2YMDA 2BYPA 3JAEA 5L4HA 4NPPA 2YN6A 4TWDA 5KE4A 5CFBA 5J5GA 4ZJSA 4IL4A 3PMZA 4AFTA 4UY2A 4HFCA 4QH5A 5HCJA 4QABA 4COFA 4IREA 3WTMA 4QH1A 5AFLA 3UU8A 4QAAA 2BR7A 4HFBA 4F8HA 3ZDGA 4XK9A 3WTHA 3ZDHA 2XQ4A 4ZK1A 5AFMA 2BYNA 4AFHA 2BG9B 2Y58A 3WTJA 5TVCA 3T4MA 4UM3S 4PIRA 3TLVA 3UU5A 3EI0A 2Y56A 4BQTA 3IGQA 3UU4A 3UU6A 1I9BA 3JADA 3ZKRA 2BR8A 2ZJVA 4ZZCA 2XQAA 4ZRUA 2XYSA 4HFIA 3U8LA 5JMEA 3RIFA 5L47A 2XNTA 2YMEA 5AFKA 2ZJUA 2BG9A 2YOEA 4IL9A 4DBMA 4ALXA 2XZ6A 3UU3A 2WNLA 3TLUA 4A98A 4D01A 4HFEA 5LG3A 3U8NA 5AFJA 2W8GA 2Y7YA 5FJVA 3GUAA 2YKSA 5HCMA 4Z91A 4ILBA 3EAMA 3EHZA 3LSVA 4HFDA 3WTNA 4TNWA 5SYOA 3SH1A 4UXUA 3P4WA 5LXBA 2XNVA 4XHEA 4TNVA 2XQ9A 3UUBA 3JAFA 4TWHA 4A97A 3WTLA 2QC1B 1UV6A 2BJ0A 2WZYA 4Z90A 2PGZA 2X00D 3TLWA 2WNCA 5HEUA 2X00A 3RQUA 4HQPA 4UM3A 4X5TA 3U8MA 5BRXA 5BW2A 5HEJA 2WN9A 3WIPA 4ZJTA 5J5IA 3TLSA 2XQ3A 3C84A 5CO5A 5J5HA 2BG9E 3UQ7A 4NZBA 3UQ4A 4AFGA 3PEOA 2BYQA 4WV9A 2XNUA 1UX2A 3U8JA 5L4EA 3WTKA 2BG9C 2UZ6A 4HFHA 2XQ8A 4QH4A 3WTOA 5J5FA 5AINA 2C9TA 5HEGA 3SIOA 5IUXA 5AFNA 4QACA 4UM1A 5J0ZA 5HEOA 4ILAA 4B5DA 5AFMB 3SQ6A 2W8FA 5BP0A 4ILCA 3U8KA 3TLTA 4LMKA 4ZR6A 5AFHA 2WNJA 2Y57A 4UM3P 4TWFA 3RQWA 4BFQA 1UW6A 3RI5A 3RHWA 3C79A 4LMJA 4LMLA 2XZ5A 2VL0A 2Y54A 3P50A 2XQ5A 2XYTA 5KZUA 5HEHA 4ZK4A 3SQ9A 3WTIA 2XQ6A 4FRRA 2XQ7A
chains in the Genus database with same CATH superfamily
2PH9A 2BYRA 3RIAA 4EZ1A 4ZZBA 2BYSA 2YMDA 2BYPA 3JAEA 5L4HA 4NPPA 2YN6A 4TWDA 5KE4A 5CFBA 5J5GA 4ZJSA 4IL4A 3PMZA 4AFTA 4UY2A 4HFCA 4QH5A 5HCJA 4QABA 4COFA 4IREA 3WTMA 4QH1A 5AFLA 3UU8A 4QAAA 2BR7A 4HFBA 4F8HA 3ZDGA 4XK9A 3WTHA 3ZDHA 2XQ4A 4ZK1A 5AFMA 2BYNA 4AFHA 2BG9B 2Y58A 3WTJA 5TVCA 3T4MA 4UM3S 4PIRA 3TLVA 3UU5A 3EI0A 2Y56A 4BQTA 3IGQA 3UU4A 3UU6A 1I9BA 3JADA 3ZKRA 2BR8A 2ZJVA 4ZZCA 2XQAA 4ZRUA 2XYSA 4HFIA 3U8LA 5JMEA 3RIFA 5L47A 2XNTA 2YMEA 5AFKA 2ZJUA 2BG9A 2YOEA 4IL9A 4DBMA 4ALXA 2XZ6A 3UU3A 2WNLA 3TLUA 4A98A 4D01A 4HFEA 5LG3A 3U8NA 5AFJA 2W8GA 2Y7YA 5FJVA 3GUAA 2YKSA 5HCMA 4Z91A 4ILBA 3EAMA 3EHZA 3LSVA 4HFDA 3WTNA 4TNWA 5SYOA 3SH1A 4UXUA 3P4WA 5LXBA 2XNVA 4XHEA 4TNVA 2XQ9A 3UUBA 3JAFA 4TWHA 4A97A 3WTLA 2QC1B 1UV6A 2BJ0A 2WZYA 4Z90A 2PGZA 2X00D 3TLWA 2WNCA 5HEUA 2X00A 3RQUA 4HQPA 4UM3A 4X5TA 3U8MA 5BRXA 5BW2A 5HEJA 2WN9A 3WIPA 4ZJTA 5J5IA 3TLSA 2XQ3A 3C84A 5CO5A 5J5HA 2BG9E 3UQ7A 4NZBA 3UQ4A 4AFGA 3PEOA 2BYQA 4WV9A 2XNUA 1UX2A 3U8JA 5L4EA 3WTKA 2BG9C 2UZ6A 4HFHA 2XQ8A 4QH4A 3WTOA 5J5FA 5AINA 2C9TA 5HEGA 3SIOA 5IUXA 5AFNA 4QACA 4UM1A 5J0ZA 5HEOA 4ILAA 4B5DA 5AFMB 3SQ6A 2W8FA 5BP0A 4ILCA 3U8KA 3TLTA 4LMKA 4ZR6A 5AFHA 2WNJA 2Y57A 4UM3P 4TWFA 3RQWA 4BFQA 1UW6A 3RI5A 3RHWA 3C79A 4LMJA 4LMLA 2XZ5A 2VL0A 2Y54A 3P50A 2XQ5A 2XYTA 5KZUA 5HEHA 4ZK4A 3SQ9A 3WTIA 2XQ6A 4FRRA 2XQ7A
chains in the Genus database with same CATH topology
2PH9A 2BYRA 3RIAA 4EZ1A 4ZZBA 2BYSA 2YMDA 2BYPA 3JAEA 5L4HA 4NPPA 2YN6A 4TWDA 5KE4A 5CFBA 5J5GA 4ZJSA 4IL4A 3PMZA 4AFTA 4UY2A 4HFCA 4QH5A 5HCJA 4QABA 4COFA 4IREA 3WTMA 4QH1A 5AFLA 3UU8A 4QAAA 2BR7A 4HFBA 4F8HA 3ZDGA 4XK9A 3WTHA 3ZDHA 2XQ4A 4ZK1A 5AFMA 2BYNA 4AFHA 2BG9B 2Y58A 3WTJA 5TVCA 3T4MA 4UM3S 4PIRA 3TLVA 3UU5A 3EI0A 2Y56A 4BQTA 3IGQA 3UU4A 3UU6A 1I9BA 3JADA 3ZKRA 2BR8A 2ZJVA 4ZZCA 2XQAA 4ZRUA 2XYSA 4HFIA 3U8LA 5JMEA 3RIFA 5L47A 2XNTA 2YMEA 5AFKA 2ZJUA 2BG9A 2YOEA 4IL9A 4DBMA 4ALXA 2XZ6A 3UU3A 2WNLA 3TLUA 4A98A 4D01A 4HFEA 5LG3A 3U8NA 5AFJA 2W8GA 2Y7YA 5FJVA 3GUAA 2YKSA 5HCMA 4Z91A 4ILBA 3EAMA 3EHZA 3LSVA 4HFDA 3WTNA 4TNWA 5SYOA 3SH1A 4UXUA 3P4WA 5LXBA 2XNVA 4XHEA 4TNVA 2XQ9A 3UUBA 3JAFA 4TWHA 4A97A 3WTLA 2QC1B 1UV6A 2BJ0A 2WZYA 4Z90A 2PGZA 2X00D 3TLWA 2WNCA 5HEUA 2X00A 3RQUA 4HQPA 4UM3A 4X5TA 3U8MA 5BRXA 5BW2A 5HEJA 2WN9A 3WIPA 4ZJTA 5J5IA 3TLSA 2XQ3A 3C84A 5CO5A 5J5HA 2BG9E 3UQ7A 4NZBA 3UQ4A 4AFGA 3PEOA 2BYQA 4WV9A 2XNUA 1UX2A 3U8JA 5L4EA 3WTKA 2BG9C 2UZ6A 4HFHA 2XQ8A 4QH4A 3WTOA 5J5FA 5AINA 2C9TA 5HEGA 3SIOA 5IUXA 5AFNA 4QACA 4UM1A 5J0ZA 5HEOA 4ILAA 4B5DA 5AFMB 3SQ6A 2W8FA 5BP0A 4ILCA 3U8KA 3TLTA 4LMKA 4ZR6A 5AFHA 2WNJA 2Y57A 4UM3P 4TWFA 3RQWA 4BFQA 1UW6A 3RI5A 3RHWA 3C79A 4LMJA 4LMLA 2XZ5A 2VL0A 2Y54A 3P50A 2XQ5A 2XYTA 5KZUA 5HEHA 4ZK4A 3SQ9A 3WTIA 2XQ6A 4FRRA 2XQ7A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2PH9 A;  2BYR A;  3RIA A;  4EZ1 A;  4ZZB A;  2BYS A;  2YMD A;  2BYP A;  3JAE A;  5L4H A;  4NPP A;  2YN6 A;  4TWD A;  5KE4 A;  5CFB A;  5J5G A;  4ZJS A;  4IL4 A;  3PMZ A;  4AFT A;  4UY2 A;  4HFC A;  4QH5 A;  5HCJ A;  4QAB A;  4COF A;  4IRE A;  3WTM A;  4QH1 A;  5AFL A;  3UU8 A;  4QAA A;  2BR7 A;  4HFB A;  4F8H A;  3ZDG A;  4XK9 A;  3WTH A;  3ZDH A;  2XQ4 A;  4ZK1 A;  5AFM A;  2BYN A;  4AFH A;  2BG9 B;  2Y58 A;  3WTJ A;  5TVC A;  3T4M A;  4UM3 S;  4PIR A;  3TLV A;  3UU5 A;  3EI0 A;  2Y56 A;  4BQT A;  3IGQ A;  3UU4 A;  3UU6 A;  1I9B A;  3JAD A;  3ZKR A;  2BR8 A;  2ZJV A;  4ZZC A;  2XQA A;  4ZRU A;  2XYS A;  4HFI A;  3U8L A;  5JME A;  3RIF A;  5L47 A;  2XNT A;  2YME A;  5AFK A;  2ZJU A;  2BG9 A;  2YOE A;  4IL9 A;  4DBM A;  4ALX A;  2XZ6 A;  3UU3 A;  2WNL A;  3TLU A;  4A98 A;  4D01 A;  4HFE A;  5LG3 A;  3U8N A;  5AFJ A;  2W8G A;  2Y7Y A;  5FJV A;  3GUA A;  2YKS A;  5HCM A;  4Z91 A;  4ILB A;  3EAM A;  3EHZ A;  3LSV A;  4HFD A;  3WTN A;  4TNW A;  5SYO A;  3SH1 A;  4UXU A;  3P4W A;  5LXB A;  2XNV A;  4XHE A;  4TNV A;  2XQ9 A;  3UUB A;  3JAF A;  4TWH A;  4A97 A;  3WTL A;  2QC1 B;  1UV6 A;  2BJ0 A;  2WZY A;  4Z90 A;  2PGZ A;  2X00 D;  3TLW A;  2WNC A;  5HEU A;  2X00 A;  3RQU A;  4HQP A;  4UM3 A;  4X5T A;  3U8M A;  5BRX A;  5BW2 A;  5HEJ A;  2WN9 A;  3WIP A;  4ZJT A;  5J5I A;  3TLS A;  2XQ3 A;  3C84 A;  5CO5 A;  5J5H A;  2BG9 E;  3UQ7 A;  4NZB A;  3UQ4 A;  4AFG A;  3PEO A;  2BYQ A;  4WV9 A;  2XNU A;  1UX2 A;  3U8J A;  5L4E A;  3WTK A;  2BG9 C;  2UZ6 A;  4HFH A;  2XQ8 A;  4QH4 A;  3WTO A;  5J5F A;  5AIN A;  2C9T A;  5HEG A;  3SIO A;  5IUX A;  5AFN A;  4QAC A;  4UM1 A;  5J0Z A;  5HEO A;  4ILA A;  4B5D A;  5AFM B;  3SQ6 A;  2W8F A;  5BP0 A;  4ILC A;  3U8K A;  3TLT A;  4LMK A;  4ZR6 A;  5AFH A;  2WNJ A;  2Y57 A;  4UM3 P;  4TWF A;  3RQW A;  4BFQ A;  1UW6 A;  3RI5 A;  3RHW A;  3C79 A;  4LMJ A;  4LML A;  2XZ5 A;  2VL0 A;  2Y54 A;  3P50 A;  2XQ5 A;  2XYT A;  5KZU A;  5HEH A;  4ZK4 A;  3SQ9 A;  3WTI A;  2XQ6 A;  4FRR A;  2XQ7 A; 
#chains in the Genus database with same CATH topology
 2PH9 A;  2BYR A;  3RIA A;  4EZ1 A;  4ZZB A;  2BYS A;  2YMD A;  2BYP A;  3JAE A;  5L4H A;  4NPP A;  2YN6 A;  4TWD A;  5KE4 A;  5CFB A;  5J5G A;  4ZJS A;  4IL4 A;  3PMZ A;  4AFT A;  4UY2 A;  4HFC A;  4QH5 A;  5HCJ A;  4QAB A;  4COF A;  4IRE A;  3WTM A;  4QH1 A;  5AFL A;  3UU8 A;  4QAA A;  2BR7 A;  4HFB A;  4F8H A;  3ZDG A;  4XK9 A;  3WTH A;  3ZDH A;  2XQ4 A;  4ZK1 A;  5AFM A;  2BYN A;  4AFH A;  2BG9 B;  2Y58 A;  3WTJ A;  5TVC A;  3T4M A;  4UM3 S;  4PIR A;  3TLV A;  3UU5 A;  3EI0 A;  2Y56 A;  4BQT A;  3IGQ A;  3UU4 A;  3UU6 A;  1I9B A;  3JAD A;  3ZKR A;  2BR8 A;  2ZJV A;  4ZZC A;  2XQA A;  4ZRU A;  2XYS A;  4HFI A;  3U8L A;  5JME A;  3RIF A;  5L47 A;  2XNT A;  2YME A;  5AFK A;  2ZJU A;  2BG9 A;  2YOE A;  4IL9 A;  4DBM A;  4ALX A;  2XZ6 A;  3UU3 A;  2WNL A;  3TLU A;  4A98 A;  4D01 A;  4HFE A;  5LG3 A;  3U8N A;  5AFJ A;  2W8G A;  2Y7Y A;  5FJV A;  3GUA A;  2YKS A;  5HCM A;  4Z91 A;  4ILB A;  3EAM A;  3EHZ A;  3LSV A;  4HFD A;  3WTN A;  4TNW A;  5SYO A;  3SH1 A;  4UXU A;  3P4W A;  5LXB A;  2XNV A;  4XHE A;  4TNV A;  2XQ9 A;  3UUB A;  3JAF A;  4TWH A;  4A97 A;  3WTL A;  2QC1 B;  1UV6 A;  2BJ0 A;  2WZY A;  4Z90 A;  2PGZ A;  2X00 D;  3TLW A;  2WNC A;  5HEU A;  2X00 A;  3RQU A;  4HQP A;  4UM3 A;  4X5T A;  3U8M A;  5BRX A;  5BW2 A;  5HEJ A;  2WN9 A;  3WIP A;  4ZJT A;  5J5I A;  3TLS A;  2XQ3 A;  3C84 A;  5CO5 A;  5J5H A;  2BG9 E;  3UQ7 A;  4NZB A;  3UQ4 A;  4AFG A;  3PEO A;  2BYQ A;  4WV9 A;  2XNU A;  1UX2 A;  3U8J A;  5L4E A;  3WTK A;  2BG9 C;  2UZ6 A;  4HFH A;  2XQ8 A;  4QH4 A;  3WTO A;  5J5F A;  5AIN A;  2C9T A;  5HEG A;  3SIO A;  5IUX A;  5AFN A;  4QAC A;  4UM1 A;  5J0Z A;  5HEO A;  4ILA A;  4B5D A;  5AFM B;  3SQ6 A;  2W8F A;  5BP0 A;  4ILC A;  3U8K A;  3TLT A;  4LMK A;  4ZR6 A;  5AFH A;  2WNJ A;  2Y57 A;  4UM3 P;  4TWF A;  3RQW A;  4BFQ A;  1UW6 A;  3RI5 A;  3RHW A;  3C79 A;  4LMJ A;  4LML A;  2XZ5 A;  2VL0 A;  2Y54 A;  3P50 A;  2XQ5 A;  2XYT A;  5KZU A;  5HEH A;  4ZK4 A;  3SQ9 A;  3WTI A;  2XQ6 A;  4FRR A;  2XQ7 A; 
#chains in the Genus database with same CATH homology
 2PH9 A;  2BYR A;  3RIA A;  4EZ1 A;  4ZZB A;  2BYS A;  2YMD A;  2BYP A;  3JAE A;  5L4H A;  4NPP A;  2YN6 A;  4TWD A;  5KE4 A;  5CFB A;  5J5G A;  4ZJS A;  4IL4 A;  3PMZ A;  4AFT A;  4UY2 A;  4HFC A;  4QH5 A;  5HCJ A;  4QAB A;  4COF A;  4IRE A;  3WTM A;  4QH1 A;  5AFL A;  3UU8 A;  4QAA A;  2BR7 A;  4HFB A;  4F8H A;  3ZDG A;  4XK9 A;  3WTH A;  3ZDH A;  2XQ4 A;  4ZK1 A;  5AFM A;  2BYN A;  4AFH A;  2BG9 B;  2Y58 A;  3WTJ A;  5TVC A;  3T4M A;  4UM3 S;  4PIR A;  3TLV A;  3UU5 A;  3EI0 A;  2Y56 A;  4BQT A;  3IGQ A;  3UU4 A;  3UU6 A;  1I9B A;  3JAD A;  3ZKR A;  2BR8 A;  2ZJV A;  4ZZC A;  2XQA A;  4ZRU A;  2XYS A;  4HFI A;  3U8L A;  5JME A;  3RIF A;  5L47 A;  2XNT A;  2YME A;  5AFK A;  2ZJU A;  2BG9 A;  2YOE A;  4IL9 A;  4DBM A;  4ALX A;  2XZ6 A;  3UU3 A;  2WNL A;  3TLU A;  4A98 A;  4D01 A;  4HFE A;  5LG3 A;  3U8N A;  5AFJ A;  2W8G A;  2Y7Y A;  5FJV A;  3GUA A;  2YKS A;  5HCM A;  4Z91 A;  4ILB A;  3EAM A;  3EHZ A;  3LSV A;  4HFD A;  3WTN A;  4TNW A;  5SYO A;  3SH1 A;  4UXU A;  3P4W A;  5LXB A;  2XNV A;  4XHE A;  4TNV A;  2XQ9 A;  3UUB A;  3JAF A;  4TWH A;  4A97 A;  3WTL A;  2QC1 B;  1UV6 A;  2BJ0 A;  2WZY A;  4Z90 A;  2PGZ A;  2X00 D;  3TLW A;  2WNC A;  5HEU A;  2X00 A;  3RQU A;  4HQP A;  4UM3 A;  4X5T A;  3U8M A;  5BRX A;  5BW2 A;  5HEJ A;  2WN9 A;  3WIP A;  4ZJT A;  5J5I A;  3TLS A;  2XQ3 A;  3C84 A;  5CO5 A;  5J5H A;  2BG9 E;  3UQ7 A;  4NZB A;  3UQ4 A;  4AFG A;  3PEO A;  2BYQ A;  4WV9 A;  2XNU A;  1UX2 A;  3U8J A;  5L4E A;  3WTK A;  2BG9 C;  2UZ6 A;  4HFH A;  2XQ8 A;  4QH4 A;  3WTO A;  5J5F A;  5AIN A;  2C9T A;  5HEG A;  3SIO A;  5IUX A;  5AFN A;  4QAC A;  4UM1 A;  5J0Z A;  5HEO A;  4ILA A;  4B5D A;  5AFM B;  3SQ6 A;  2W8F A;  5BP0 A;  4ILC A;  3U8K A;  3TLT A;  4LMK A;  4ZR6 A;  5AFH A;  2WNJ A;  2Y57 A;  4UM3 P;  4TWF A;  3RQW A;  4BFQ A;  1UW6 A;  3RI5 A;  3RHW A;  3C79 A;  4LMJ A;  4LML A;  2XZ5 A;  2VL0 A;  2Y54 A;  3P50 A;  2XQ5 A;  2XYT A;  5KZU A;  5HEH A;  4ZK4 A;  3SQ9 A;  3WTI A;  2XQ6 A;  4FRR A;  2XQ7 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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