3U8KA

Crystal structure of the acetylcholine binding protein (achbp) from lymnaea stagnalis in complex with ns3573 (1-(5-ethoxypyridin-3-yl)-1,4-diazepane)
Total Genus 49
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
49
sequence length
209
structure length
209
Chain Sequence
LDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLARVVSDGEVLYMPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTTENSDDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKGRSEI
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Acetylcholine-binding protein/agonist
source organism Lymnaea stagnalis
publication title Intersubunit bridge formation governs agonist efficacy at nicotinic acetylcholine alpha 4 beta 2 receptors: unique role of halogen bonding revealed.
pubmed doi rcsb
molecule keywords Acetylcholine-binding protein
total genus 49
structure length 209
sequence length 209
chains with identical sequence B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T
ec nomenclature
pdb deposition date 2011-10-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02931 Neur_chan_LBD Neurotransmitter-gated ion-channel ligand binding domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.170.10 Mainly Beta Distorted Sandwich Acetylcholine Binding Protein; Chain: A, Neurotransmitter-gated ion-channel ligand-binding domain 3u8kA00
4A97A 2PH9A 4QH5A 3UU3A 3JADA 3UU8A 2BYNA 3UQ4A 3GUAA 2XQ4A 3RIAA 3SIOA 3SQ9A 3WIPA 5AFJA 4LMJA 3WTJA 4ZRUA 2BYPA 4HFDA 5HEGA 3U8MA 2YOEA 4XHEA 3P50A 1UW6A 2XZ5A 3JAFA 3UUBA 4EZ1A 5CFBA 2ZJUA 4UM3P 2XQ7A 2YKSA 2WNJA 3WTOA 3LSVA 5AINA 2X00A 2XQ6A 5AFLA 4ILAA 5AFKA 4TWHA 2WNLA 4D01A 2XYSA 4UY2A 4ZR6A 3RQWA 3ZKRA 5KZUA 4ILCA 5J5FA 3WTIA 5AFHA 4PIRA 3RQUA 1UX2A 3U8NA 2BYRA 4TNWA 5BW2A 4UXUA 4XK9A 4Z90A 4ZK4A 4AFGA 5AFMA 2XQ9A 2XQ3A 4DBMA 2YN6A 2ZJVA 4IL9A 3SQ6A 5FJVA 3WTMA 4BQTA 2YMEA 4LMLA 2BG9A 4QABA 4NPPA 4A98A 4UM1A 5HCJA 5HEHA 5AFNA 5AFMB 4B5DA 5BP0A 2BYSA 5HEOA 2YMDA 3EI0A 4LMKA 3WTKA 2W8GA 4WV9A 5HEJA 3U8JA 4ZZCA 4Z91A 5LG3A 4QH1A 4QACA 4HFCA 2BG9E 2BG9B 5TVCA 2PGZA 3UU4A 5HEUA 5L47A 4AFHA 4ZJSA 3JAEA 2UZ6A 4HFBA 4X5TA 3RI5A 3ZDGA 5IUXA 3ZDHA 3WTHA 3TLUA 5KE4A 5J0ZA 2BYQA 3IGQA 3TLTA 2XNTA 5BRXA 2BJ0A 2XNVA 3U8KA 2BR8A 2BR7A 2WNCA 2X00D 2Y7YA 3EHZA 4TWDA 2Y57A 4TWFA 3SH1A 4HFEA 3WTLA 2Y58A 5J5GA 4HQPA 3U8LA 5J5IA 5SYOA 3TLVA 4TNVA 3UQ7A 3UU6A 3RIFA 4BFQA 4QAAA 5L4EA 2WZYA 3P4WA 4HFIA 4COFA 4FRRA 2Y56A 4UM3A 4F8HA 4ALXA 4ZZBA 4ZJTA 4AFTA 5LXBA 2C9TA 4QH4A 5HCMA 2QC1B 4HFHA 3UU5A 3WTNA 3PMZA 5CO5A 2XQ8A 5L4HA 4IREA 4IL4A 4UM3S 3EAMA 4ZK1A 1I9BA 3RHWA 2XQ5A 3TLSA 1UV6A 3PEOA 2XYTA 2XNUA 2BG9C 2WN9A 4NZBA 2XZ6A 3T4MA 2XQAA 3C79A 2W8FA 2Y54A 3C84A 4ILBA 3TLWA 5J5HA 5JMEA 2VL0A
chains in the Genus database with same CATH superfamily
4A97A 2PH9A 4QH5A 3UU3A 3JADA 3UU8A 2BYNA 3UQ4A 3GUAA 2XQ4A 3RIAA 3SIOA 3SQ9A 3WIPA 5AFJA 4LMJA 3WTJA 4ZRUA 2BYPA 4HFDA 5HEGA 3U8MA 2YOEA 4XHEA 3P50A 1UW6A 2XZ5A 3JAFA 3UUBA 4EZ1A 5CFBA 2ZJUA 4UM3P 2XQ7A 2YKSA 2WNJA 3WTOA 3LSVA 5AINA 2X00A 2XQ6A 5AFLA 4ILAA 5AFKA 4TWHA 2WNLA 4D01A 2XYSA 4UY2A 4ZR6A 3RQWA 3ZKRA 5KZUA 4ILCA 5J5FA 3WTIA 5AFHA 4PIRA 3RQUA 1UX2A 3U8NA 2BYRA 4TNWA 5BW2A 4UXUA 4XK9A 4Z90A 4ZK4A 4AFGA 5AFMA 2XQ9A 2XQ3A 4DBMA 2YN6A 2ZJVA 4IL9A 3SQ6A 5FJVA 3WTMA 4BQTA 2YMEA 4LMLA 2BG9A 4QABA 4NPPA 4A98A 4UM1A 5HCJA 5HEHA 5AFNA 5AFMB 4B5DA 5BP0A 2BYSA 5HEOA 2YMDA 3EI0A 4LMKA 3WTKA 2W8GA 4WV9A 5HEJA 3U8JA 4ZZCA 4Z91A 5LG3A 4QH1A 4QACA 4HFCA 2BG9E 2BG9B 5TVCA 2PGZA 3UU4A 5HEUA 5L47A 4AFHA 4ZJSA 3JAEA 2UZ6A 4HFBA 4X5TA 3RI5A 3ZDGA 5IUXA 3ZDHA 3WTHA 3TLUA 5KE4A 5J0ZA 2BYQA 3IGQA 3TLTA 2XNTA 5BRXA 2BJ0A 2XNVA 3U8KA 2BR8A 2BR7A 2WNCA 2X00D 2Y7YA 3EHZA 4TWDA 2Y57A 4TWFA 3SH1A 4HFEA 3WTLA 2Y58A 5J5GA 4HQPA 3U8LA 5J5IA 5SYOA 3TLVA 4TNVA 3UQ7A 3UU6A 3RIFA 4BFQA 4QAAA 5L4EA 2WZYA 3P4WA 4HFIA 4COFA 4FRRA 2Y56A 4UM3A 4F8HA 4ALXA 4ZZBA 4ZJTA 4AFTA 5LXBA 2C9TA 4QH4A 5HCMA 2QC1B 4HFHA 3UU5A 3WTNA 3PMZA 5CO5A 2XQ8A 5L4HA 4IREA 4IL4A 4UM3S 3EAMA 4ZK1A 1I9BA 3RHWA 2XQ5A 3TLSA 1UV6A 3PEOA 2XYTA 2XNUA 2BG9C 2WN9A 4NZBA 2XZ6A 3T4MA 2XQAA 3C79A 2W8FA 2Y54A 3C84A 4ILBA 3TLWA 5J5HA 5JMEA 2VL0A
chains in the Genus database with same CATH topology
4A97A 2PH9A 4QH5A 3UU3A 3JADA 3UU8A 2BYNA 3UQ4A 3GUAA 2XQ4A 3RIAA 3SIOA 3SQ9A 3WIPA 5AFJA 4LMJA 3WTJA 4ZRUA 2BYPA 4HFDA 5HEGA 3U8MA 2YOEA 4XHEA 3P50A 1UW6A 2XZ5A 3JAFA 3UUBA 4EZ1A 5CFBA 2ZJUA 4UM3P 2XQ7A 2YKSA 2WNJA 3WTOA 3LSVA 5AINA 2X00A 2XQ6A 5AFLA 4ILAA 5AFKA 4TWHA 2WNLA 4D01A 2XYSA 4UY2A 4ZR6A 3RQWA 3ZKRA 5KZUA 4ILCA 5J5FA 3WTIA 5AFHA 4PIRA 3RQUA 1UX2A 3U8NA 2BYRA 4TNWA 5BW2A 4UXUA 4XK9A 4Z90A 4ZK4A 4AFGA 5AFMA 2XQ9A 2XQ3A 4DBMA 2YN6A 2ZJVA 4IL9A 3SQ6A 5FJVA 3WTMA 4BQTA 2YMEA 4LMLA 2BG9A 4QABA 4NPPA 4A98A 4UM1A 5HCJA 5HEHA 5AFNA 5AFMB 4B5DA 5BP0A 2BYSA 5HEOA 2YMDA 3EI0A 4LMKA 3WTKA 2W8GA 4WV9A 5HEJA 3U8JA 4ZZCA 4Z91A 5LG3A 4QH1A 4QACA 4HFCA 2BG9E 2BG9B 5TVCA 2PGZA 3UU4A 5HEUA 5L47A 4AFHA 4ZJSA 3JAEA 2UZ6A 4HFBA 4X5TA 3RI5A 3ZDGA 5IUXA 3ZDHA 3WTHA 3TLUA 5KE4A 5J0ZA 2BYQA 3IGQA 3TLTA 2XNTA 5BRXA 2BJ0A 2XNVA 3U8KA 2BR8A 2BR7A 2WNCA 2X00D 2Y7YA 3EHZA 4TWDA 2Y57A 4TWFA 3SH1A 4HFEA 3WTLA 2Y58A 5J5GA 4HQPA 3U8LA 5J5IA 5SYOA 3TLVA 4TNVA 3UQ7A 3UU6A 3RIFA 4BFQA 4QAAA 5L4EA 2WZYA 3P4WA 4HFIA 4COFA 4FRRA 2Y56A 4UM3A 4F8HA 4ALXA 4ZZBA 4ZJTA 4AFTA 5LXBA 2C9TA 4QH4A 5HCMA 2QC1B 4HFHA 3UU5A 3WTNA 3PMZA 5CO5A 2XQ8A 5L4HA 4IREA 4IL4A 4UM3S 3EAMA 4ZK1A 1I9BA 3RHWA 2XQ5A 3TLSA 1UV6A 3PEOA 2XYTA 2XNUA 2BG9C 2WN9A 4NZBA 2XZ6A 3T4MA 2XQAA 3C79A 2W8FA 2Y54A 3C84A 4ILBA 3TLWA 5J5HA 5JMEA 2VL0A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4A97 A;  2PH9 A;  4QH5 A;  3UU3 A;  3JAD A;  3UU8 A;  2BYN A;  3UQ4 A;  3GUA A;  2XQ4 A;  3RIA A;  3SIO A;  3SQ9 A;  3WIP A;  5AFJ A;  4LMJ A;  3WTJ A;  4ZRU A;  2BYP A;  4HFD A;  5HEG A;  3U8M A;  2YOE A;  4XHE A;  3P50 A;  1UW6 A;  2XZ5 A;  3JAF A;  3UUB A;  4EZ1 A;  5CFB A;  2ZJU A;  4UM3 P;  2XQ7 A;  2YKS A;  2WNJ A;  3WTO A;  3LSV A;  5AIN A;  2X00 A;  2XQ6 A;  5AFL A;  4ILA A;  5AFK A;  4TWH A;  2WNL A;  4D01 A;  2XYS A;  4UY2 A;  4ZR6 A;  3RQW A;  3ZKR A;  5KZU A;  4ILC A;  5J5F A;  3WTI A;  5AFH A;  4PIR A;  3RQU A;  1UX2 A;  3U8N A;  2BYR A;  4TNW A;  5BW2 A;  4UXU A;  4XK9 A;  4Z90 A;  4ZK4 A;  4AFG A;  5AFM A;  2XQ9 A;  2XQ3 A;  4DBM A;  2YN6 A;  2ZJV A;  4IL9 A;  3SQ6 A;  5FJV A;  3WTM A;  4BQT A;  2YME A;  4LML A;  2BG9 A;  4QAB A;  4NPP A;  4A98 A;  4UM1 A;  5HCJ A;  5HEH A;  5AFN A;  5AFM B;  4B5D A;  5BP0 A;  2BYS A;  5HEO A;  2YMD A;  3EI0 A;  4LMK A;  3WTK A;  2W8G A;  4WV9 A;  5HEJ A;  3U8J A;  4ZZC A;  4Z91 A;  5LG3 A;  4QH1 A;  4QAC A;  4HFC A;  2BG9 E;  2BG9 B;  5TVC A;  2PGZ A;  3UU4 A;  5HEU A;  5L47 A;  4AFH A;  4ZJS A;  3JAE A;  2UZ6 A;  4HFB A;  4X5T A;  3RI5 A;  3ZDG A;  5IUX A;  3ZDH A;  3WTH A;  3TLU A;  5KE4 A;  5J0Z A;  2BYQ A;  3IGQ A;  3TLT A;  2XNT A;  5BRX A;  2BJ0 A;  2XNV A;  3U8K A;  2BR8 A;  2BR7 A;  2WNC A;  2X00 D;  2Y7Y A;  3EHZ A;  4TWD A;  2Y57 A;  4TWF A;  3SH1 A;  4HFE A;  3WTL A;  2Y58 A;  5J5G A;  4HQP A;  3U8L A;  5J5I A;  5SYO A;  3TLV A;  4TNV A;  3UQ7 A;  3UU6 A;  3RIF A;  4BFQ A;  4QAA A;  5L4E A;  2WZY A;  3P4W A;  4HFI A;  4COF A;  4FRR A;  2Y56 A;  4UM3 A;  4F8H A;  4ALX A;  4ZZB A;  4ZJT A;  4AFT A;  5LXB A;  2C9T A;  4QH4 A;  5HCM A;  2QC1 B;  4HFH A;  3UU5 A;  3WTN A;  3PMZ A;  5CO5 A;  2XQ8 A;  5L4H A;  4IRE A;  4IL4 A;  4UM3 S;  3EAM A;  4ZK1 A;  1I9B A;  3RHW A;  2XQ5 A;  3TLS A;  1UV6 A;  3PEO A;  2XYT A;  2XNU A;  2BG9 C;  2WN9 A;  4NZB A;  2XZ6 A;  3T4M A;  2XQA A;  3C79 A;  2W8F A;  2Y54 A;  3C84 A;  4ILB A;  3TLW A;  5J5H A;  5JME A;  2VL0 A; 
#chains in the Genus database with same CATH topology
 4A97 A;  2PH9 A;  4QH5 A;  3UU3 A;  3JAD A;  3UU8 A;  2BYN A;  3UQ4 A;  3GUA A;  2XQ4 A;  3RIA A;  3SIO A;  3SQ9 A;  3WIP A;  5AFJ A;  4LMJ A;  3WTJ A;  4ZRU A;  2BYP A;  4HFD A;  5HEG A;  3U8M A;  2YOE A;  4XHE A;  3P50 A;  1UW6 A;  2XZ5 A;  3JAF A;  3UUB A;  4EZ1 A;  5CFB A;  2ZJU A;  4UM3 P;  2XQ7 A;  2YKS A;  2WNJ A;  3WTO A;  3LSV A;  5AIN A;  2X00 A;  2XQ6 A;  5AFL A;  4ILA A;  5AFK A;  4TWH A;  2WNL A;  4D01 A;  2XYS A;  4UY2 A;  4ZR6 A;  3RQW A;  3ZKR A;  5KZU A;  4ILC A;  5J5F A;  3WTI A;  5AFH A;  4PIR A;  3RQU A;  1UX2 A;  3U8N A;  2BYR A;  4TNW A;  5BW2 A;  4UXU A;  4XK9 A;  4Z90 A;  4ZK4 A;  4AFG A;  5AFM A;  2XQ9 A;  2XQ3 A;  4DBM A;  2YN6 A;  2ZJV A;  4IL9 A;  3SQ6 A;  5FJV A;  3WTM A;  4BQT A;  2YME A;  4LML A;  2BG9 A;  4QAB A;  4NPP A;  4A98 A;  4UM1 A;  5HCJ A;  5HEH A;  5AFN A;  5AFM B;  4B5D A;  5BP0 A;  2BYS A;  5HEO A;  2YMD A;  3EI0 A;  4LMK A;  3WTK A;  2W8G A;  4WV9 A;  5HEJ A;  3U8J A;  4ZZC A;  4Z91 A;  5LG3 A;  4QH1 A;  4QAC A;  4HFC A;  2BG9 E;  2BG9 B;  5TVC A;  2PGZ A;  3UU4 A;  5HEU A;  5L47 A;  4AFH A;  4ZJS A;  3JAE A;  2UZ6 A;  4HFB A;  4X5T A;  3RI5 A;  3ZDG A;  5IUX A;  3ZDH A;  3WTH A;  3TLU A;  5KE4 A;  5J0Z A;  2BYQ A;  3IGQ A;  3TLT A;  2XNT A;  5BRX A;  2BJ0 A;  2XNV A;  3U8K A;  2BR8 A;  2BR7 A;  2WNC A;  2X00 D;  2Y7Y A;  3EHZ A;  4TWD A;  2Y57 A;  4TWF A;  3SH1 A;  4HFE A;  3WTL A;  2Y58 A;  5J5G A;  4HQP A;  3U8L A;  5J5I A;  5SYO A;  3TLV A;  4TNV A;  3UQ7 A;  3UU6 A;  3RIF A;  4BFQ A;  4QAA A;  5L4E A;  2WZY A;  3P4W A;  4HFI A;  4COF A;  4FRR A;  2Y56 A;  4UM3 A;  4F8H A;  4ALX A;  4ZZB A;  4ZJT A;  4AFT A;  5LXB A;  2C9T A;  4QH4 A;  5HCM A;  2QC1 B;  4HFH A;  3UU5 A;  3WTN A;  3PMZ A;  5CO5 A;  2XQ8 A;  5L4H A;  4IRE A;  4IL4 A;  4UM3 S;  3EAM A;  4ZK1 A;  1I9B A;  3RHW A;  2XQ5 A;  3TLS A;  1UV6 A;  3PEO A;  2XYT A;  2XNU A;  2BG9 C;  2WN9 A;  4NZB A;  2XZ6 A;  3T4M A;  2XQA A;  3C79 A;  2W8F A;  2Y54 A;  3C84 A;  4ILB A;  3TLW A;  5J5H A;  5JME A;  2VL0 A; 
#chains in the Genus database with same CATH homology
 4A97 A;  2PH9 A;  4QH5 A;  3UU3 A;  3JAD A;  3UU8 A;  2BYN A;  3UQ4 A;  3GUA A;  2XQ4 A;  3RIA A;  3SIO A;  3SQ9 A;  3WIP A;  5AFJ A;  4LMJ A;  3WTJ A;  4ZRU A;  2BYP A;  4HFD A;  5HEG A;  3U8M A;  2YOE A;  4XHE A;  3P50 A;  1UW6 A;  2XZ5 A;  3JAF A;  3UUB A;  4EZ1 A;  5CFB A;  2ZJU A;  4UM3 P;  2XQ7 A;  2YKS A;  2WNJ A;  3WTO A;  3LSV A;  5AIN A;  2X00 A;  2XQ6 A;  5AFL A;  4ILA A;  5AFK A;  4TWH A;  2WNL A;  4D01 A;  2XYS A;  4UY2 A;  4ZR6 A;  3RQW A;  3ZKR A;  5KZU A;  4ILC A;  5J5F A;  3WTI A;  5AFH A;  4PIR A;  3RQU A;  1UX2 A;  3U8N A;  2BYR A;  4TNW A;  5BW2 A;  4UXU A;  4XK9 A;  4Z90 A;  4ZK4 A;  4AFG A;  5AFM A;  2XQ9 A;  2XQ3 A;  4DBM A;  2YN6 A;  2ZJV A;  4IL9 A;  3SQ6 A;  5FJV A;  3WTM A;  4BQT A;  2YME A;  4LML A;  2BG9 A;  4QAB A;  4NPP A;  4A98 A;  4UM1 A;  5HCJ A;  5HEH A;  5AFN A;  5AFM B;  4B5D A;  5BP0 A;  2BYS A;  5HEO A;  2YMD A;  3EI0 A;  4LMK A;  3WTK A;  2W8G A;  4WV9 A;  5HEJ A;  3U8J A;  4ZZC A;  4Z91 A;  5LG3 A;  4QH1 A;  4QAC A;  4HFC A;  2BG9 E;  2BG9 B;  5TVC A;  2PGZ A;  3UU4 A;  5HEU A;  5L47 A;  4AFH A;  4ZJS A;  3JAE A;  2UZ6 A;  4HFB A;  4X5T A;  3RI5 A;  3ZDG A;  5IUX A;  3ZDH A;  3WTH A;  3TLU A;  5KE4 A;  5J0Z A;  2BYQ A;  3IGQ A;  3TLT A;  2XNT A;  5BRX A;  2BJ0 A;  2XNV A;  3U8K A;  2BR8 A;  2BR7 A;  2WNC A;  2X00 D;  2Y7Y A;  3EHZ A;  4TWD A;  2Y57 A;  4TWF A;  3SH1 A;  4HFE A;  3WTL A;  2Y58 A;  5J5G A;  4HQP A;  3U8L A;  5J5I A;  5SYO A;  3TLV A;  4TNV A;  3UQ7 A;  3UU6 A;  3RIF A;  4BFQ A;  4QAA A;  5L4E A;  2WZY A;  3P4W A;  4HFI A;  4COF A;  4FRR A;  2Y56 A;  4UM3 A;  4F8H A;  4ALX A;  4ZZB A;  4ZJT A;  4AFT A;  5LXB A;  2C9T A;  4QH4 A;  5HCM A;  2QC1 B;  4HFH A;  3UU5 A;  3WTN A;  3PMZ A;  5CO5 A;  2XQ8 A;  5L4H A;  4IRE A;  4IL4 A;  4UM3 S;  3EAM A;  4ZK1 A;  1I9B A;  3RHW A;  2XQ5 A;  3TLS A;  1UV6 A;  3PEO A;  2XYT A;  2XNU A;  2BG9 C;  2WN9 A;  4NZB A;  2XZ6 A;  3T4M A;  2XQA A;  3C79 A;  2W8F A;  2Y54 A;  3C84 A;  4ILB A;  3TLW A;  5J5H A;  5JME A;  2VL0 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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