3U8LA

Crystal structure of the acetylcholine binding protein (achbp) from lymnaea stagnalis in complex with ns3570 (1-(5-phenylpyridin-3-yl)-1,4-diazepane)
Total Genus 49
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
49
sequence length
205
structure length
202
Chain Sequence
LDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLARVVSDGEVLYMPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTTDDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Intersubunit bridge formation governs agonist efficacy at nicotinic acetylcholine alpha 4 beta 2 receptors: unique role of halogen bonding revealed.
pubmed doi rcsb
molecule tags Acetylcholine-binding protein/agonist
source organism Lymnaea stagnalis
molecule keywords Acetylcholine-binding protein
total genus 49
structure length 202
sequence length 205
chains with identical sequence B, C, D, E, F, G, H, I, J
ec nomenclature
pdb deposition date 2011-10-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02931 Neur_chan_LBD Neurotransmitter-gated ion-channel ligand binding domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.170.10 Mainly Beta Distorted Sandwich Acetylcholine Binding Protein; Chain: A, Neurotransmitter-gated ion-channel ligand-binding domain 3u8lA00
2WNCA 3LSVA 2WNJA 2XQ4A 3WTLA 5AFJA 3UQ4A 5HCJA 3WTKA 4QH4A 3U8KA 2XQ6A 4D01A 5J0ZA 2XNVA 5AFLA 2X00A 4ZK4A 2ZJUA 3TLWA 3UU4A 2XZ6A 3WTHA 3UU6A 4LMJA 3EHZA 5HEOA 4XHEA 2XQ7A 4QH1A 5L4HA 4HFHA 4ZK1A 3GUAA 3JAEA 1UX2A 3RIAA 2XNTA 2YKSA 4IL4A 4F8HA 3JAFA 4ILBA 1UV6A 1UW6A 3EAMA 3IGQA 3C79A 4IL9A 2YMEA 3SQ6A 5CFBA 5HEJA 3UQ7A 4HQPA 5SYOA 3ZDHA 3U8JA 2BG9C 3EI0A 2WN9A 4HFBA 3TLVA 4B5DA 3RQWA 3JADA 5BRXA 5IUXA 2Y7YA 2QC1B 3U8NA 3SQ9A 4UM3P 5HEUA 4ZRUA 3ZDGA 5LG3A 2VL0A 2Y54A 4UXUA 3RI5A 4BFQA 4DBMA 5BP0A 4UY2A 2BYNA 5TVCA 3U8LA 5AFHA 4ALXA 1I9BA 3T4MA 2Y56A 5HEGA 5J5HA 5AINA 4QACA 4NPPA 3WTJA 4IREA 2PH9A 2YOEA 5FJVA 4HFIA 2XQ3A 2WNLA 3WTMA 5CO5A 5KE4A 2W8FA 3UU5A 3TLUA 5HCMA 2BYRA 4HFDA 4UM1A 3RQUA 4TWFA 4A98A 4LMLA 2Y58A 4FRRA 2ZJVA 4TNWA 3SIOA 4AFHA 4HFEA 3TLTA 2XQAA 3U8MA 2XYTA 4QAAA 4ZZCA 4QABA 3UUBA 5AFMA 3WTOA 4EZ1A 3PMZA 4ZR6A 2BG9A 4ZZBA 5J5IA 5J5FA 2XQ8A 4HFCA 3P4WA 4ILAA 4LMKA 3C84A 2UZ6A 4TWHA 3WIPA 4AFTA 4X5TA 4WV9A 4BQTA 2YMDA 5JMEA 5AFNA 3WTNA 5KZUA 4A97A 5BW2A 2XQ9A 4QH5A 2WZYA 2XZ5A 3P50A 2C9TA 2W8GA 2PGZA 5J5GA 4AFGA 5L47A 3RHWA 2BR8A 5L4EA 5AFMB 3UU8A 4PIRA 2BG9B 2XNUA 4TWDA 4Z91A 2BYSA 4NZBA 4ZJSA 3RIFA 3WTIA 4COFA 3TLSA 2YN6A 4XK9A 2BG9E 3PEOA 2BJ0A 2XYSA 5AFKA 3UU3A 2XQ5A 2Y57A 4UM3S 3ZKRA 4Z90A 4TNVA 5LXBA 2X00D 4ILCA 5HEHA 2BR7A 3SH1A 4ZJTA 2BYPA 4UM3A 2BYQA
chains in the Genus database with same CATH superfamily
2WNCA 3LSVA 2WNJA 2XQ4A 3WTLA 5AFJA 3UQ4A 5HCJA 3WTKA 4QH4A 3U8KA 2XQ6A 4D01A 5J0ZA 2XNVA 5AFLA 2X00A 4ZK4A 2ZJUA 3TLWA 3UU4A 2XZ6A 3WTHA 3UU6A 4LMJA 3EHZA 5HEOA 4XHEA 2XQ7A 4QH1A 5L4HA 4HFHA 4ZK1A 3GUAA 3JAEA 1UX2A 3RIAA 2XNTA 2YKSA 4IL4A 4F8HA 3JAFA 4ILBA 1UV6A 1UW6A 3EAMA 3IGQA 3C79A 4IL9A 2YMEA 3SQ6A 5CFBA 5HEJA 3UQ7A 4HQPA 5SYOA 3ZDHA 3U8JA 2BG9C 3EI0A 2WN9A 4HFBA 3TLVA 4B5DA 3RQWA 3JADA 5BRXA 5IUXA 2Y7YA 2QC1B 3U8NA 3SQ9A 4UM3P 5HEUA 4ZRUA 3ZDGA 5LG3A 2VL0A 2Y54A 4UXUA 3RI5A 4BFQA 4DBMA 5BP0A 4UY2A 2BYNA 5TVCA 3U8LA 5AFHA 4ALXA 1I9BA 3T4MA 2Y56A 5HEGA 5J5HA 5AINA 4QACA 4NPPA 3WTJA 4IREA 2PH9A 2YOEA 5FJVA 4HFIA 2XQ3A 2WNLA 3WTMA 5CO5A 5KE4A 2W8FA 3UU5A 3TLUA 5HCMA 2BYRA 4HFDA 4UM1A 3RQUA 4TWFA 4A98A 4LMLA 2Y58A 4FRRA 2ZJVA 4TNWA 3SIOA 4AFHA 4HFEA 3TLTA 2XQAA 3U8MA 2XYTA 4QAAA 4ZZCA 4QABA 3UUBA 5AFMA 3WTOA 4EZ1A 3PMZA 4ZR6A 2BG9A 4ZZBA 5J5IA 5J5FA 2XQ8A 4HFCA 3P4WA 4ILAA 4LMKA 3C84A 2UZ6A 4TWHA 3WIPA 4AFTA 4X5TA 4WV9A 4BQTA 2YMDA 5JMEA 5AFNA 3WTNA 5KZUA 4A97A 5BW2A 2XQ9A 4QH5A 2WZYA 2XZ5A 3P50A 2C9TA 2W8GA 2PGZA 5J5GA 4AFGA 5L47A 3RHWA 2BR8A 5L4EA 5AFMB 3UU8A 4PIRA 2BG9B 2XNUA 4TWDA 4Z91A 2BYSA 4NZBA 4ZJSA 3RIFA 3WTIA 4COFA 3TLSA 2YN6A 4XK9A 2BG9E 3PEOA 2BJ0A 2XYSA 5AFKA 3UU3A 2XQ5A 2Y57A 4UM3S 3ZKRA 4Z90A 4TNVA 5LXBA 2X00D 4ILCA 5HEHA 2BR7A 3SH1A 4ZJTA 2BYPA 4UM3A 2BYQA
chains in the Genus database with same CATH topology
2WNCA 3LSVA 2WNJA 2XQ4A 3WTLA 5AFJA 3UQ4A 5HCJA 3WTKA 4QH4A 3U8KA 2XQ6A 4D01A 5J0ZA 2XNVA 5AFLA 2X00A 4ZK4A 2ZJUA 3TLWA 3UU4A 2XZ6A 3WTHA 3UU6A 4LMJA 3EHZA 5HEOA 4XHEA 2XQ7A 4QH1A 5L4HA 4HFHA 4ZK1A 3GUAA 3JAEA 1UX2A 3RIAA 2XNTA 2YKSA 4IL4A 4F8HA 3JAFA 4ILBA 1UV6A 1UW6A 3EAMA 3IGQA 3C79A 4IL9A 2YMEA 3SQ6A 5CFBA 5HEJA 3UQ7A 4HQPA 5SYOA 3ZDHA 3U8JA 2BG9C 3EI0A 2WN9A 4HFBA 3TLVA 4B5DA 3RQWA 3JADA 5BRXA 5IUXA 2Y7YA 2QC1B 3U8NA 3SQ9A 4UM3P 5HEUA 4ZRUA 3ZDGA 5LG3A 2VL0A 2Y54A 4UXUA 3RI5A 4BFQA 4DBMA 5BP0A 4UY2A 2BYNA 5TVCA 3U8LA 5AFHA 4ALXA 1I9BA 3T4MA 2Y56A 5HEGA 5J5HA 5AINA 4QACA 4NPPA 3WTJA 4IREA 2PH9A 2YOEA 5FJVA 4HFIA 2XQ3A 2WNLA 3WTMA 5CO5A 5KE4A 2W8FA 3UU5A 3TLUA 5HCMA 2BYRA 4HFDA 4UM1A 3RQUA 4TWFA 4A98A 4LMLA 2Y58A 4FRRA 2ZJVA 4TNWA 3SIOA 4AFHA 4HFEA 3TLTA 2XQAA 3U8MA 2XYTA 4QAAA 4ZZCA 4QABA 3UUBA 5AFMA 3WTOA 4EZ1A 3PMZA 4ZR6A 2BG9A 4ZZBA 5J5IA 5J5FA 2XQ8A 4HFCA 3P4WA 4ILAA 4LMKA 3C84A 2UZ6A 4TWHA 3WIPA 4AFTA 4X5TA 4WV9A 4BQTA 2YMDA 5JMEA 5AFNA 3WTNA 5KZUA 4A97A 5BW2A 2XQ9A 4QH5A 2WZYA 2XZ5A 3P50A 2C9TA 2W8GA 2PGZA 5J5GA 4AFGA 5L47A 3RHWA 2BR8A 5L4EA 5AFMB 3UU8A 4PIRA 2BG9B 2XNUA 4TWDA 4Z91A 2BYSA 4NZBA 4ZJSA 3RIFA 3WTIA 4COFA 3TLSA 2YN6A 4XK9A 2BG9E 3PEOA 2BJ0A 2XYSA 5AFKA 3UU3A 2XQ5A 2Y57A 4UM3S 3ZKRA 4Z90A 4TNVA 5LXBA 2X00D 4ILCA 5HEHA 2BR7A 3SH1A 4ZJTA 2BYPA 4UM3A 2BYQA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2WNC A;  3LSV A;  2WNJ A;  2XQ4 A;  3WTL A;  5AFJ A;  3UQ4 A;  5HCJ A;  3WTK A;  4QH4 A;  3U8K A;  2XQ6 A;  4D01 A;  5J0Z A;  2XNV A;  5AFL A;  2X00 A;  4ZK4 A;  2ZJU A;  3TLW A;  3UU4 A;  2XZ6 A;  3WTH A;  3UU6 A;  4LMJ A;  3EHZ A;  5HEO A;  4XHE A;  2XQ7 A;  4QH1 A;  5L4H A;  4HFH A;  4ZK1 A;  3GUA A;  3JAE A;  1UX2 A;  3RIA A;  2XNT A;  2YKS A;  4IL4 A;  4F8H A;  3JAF A;  4ILB A;  1UV6 A;  1UW6 A;  3EAM A;  3IGQ A;  3C79 A;  4IL9 A;  2YME A;  3SQ6 A;  5CFB A;  5HEJ A;  3UQ7 A;  4HQP A;  5SYO A;  3ZDH A;  3U8J A;  2BG9 C;  3EI0 A;  2WN9 A;  4HFB A;  3TLV A;  4B5D A;  3RQW A;  3JAD A;  5BRX A;  5IUX A;  2Y7Y A;  2QC1 B;  3U8N A;  3SQ9 A;  4UM3 P;  5HEU A;  4ZRU A;  3ZDG A;  5LG3 A;  2VL0 A;  2Y54 A;  4UXU A;  3RI5 A;  4BFQ A;  4DBM A;  5BP0 A;  4UY2 A;  2BYN A;  5TVC A;  3U8L A;  5AFH A;  4ALX A;  1I9B A;  3T4M A;  2Y56 A;  5HEG A;  5J5H A;  5AIN A;  4QAC A;  4NPP A;  3WTJ A;  4IRE A;  2PH9 A;  2YOE A;  5FJV A;  4HFI A;  2XQ3 A;  2WNL A;  3WTM A;  5CO5 A;  5KE4 A;  2W8F A;  3UU5 A;  3TLU A;  5HCM A;  2BYR A;  4HFD A;  4UM1 A;  3RQU A;  4TWF A;  4A98 A;  4LML A;  2Y58 A;  4FRR A;  2ZJV A;  4TNW A;  3SIO A;  4AFH A;  4HFE A;  3TLT A;  2XQA A;  3U8M A;  2XYT A;  4QAA A;  4ZZC A;  4QAB A;  3UUB A;  5AFM A;  3WTO A;  4EZ1 A;  3PMZ A;  4ZR6 A;  2BG9 A;  4ZZB A;  5J5I A;  5J5F A;  2XQ8 A;  4HFC A;  3P4W A;  4ILA A;  4LMK A;  3C84 A;  2UZ6 A;  4TWH A;  3WIP A;  4AFT A;  4X5T A;  4WV9 A;  4BQT A;  2YMD A;  5JME A;  5AFN A;  3WTN A;  5KZU A;  4A97 A;  5BW2 A;  2XQ9 A;  4QH5 A;  2WZY A;  2XZ5 A;  3P50 A;  2C9T A;  2W8G A;  2PGZ A;  5J5G A;  4AFG A;  5L47 A;  3RHW A;  2BR8 A;  5L4E A;  5AFM B;  3UU8 A;  4PIR A;  2BG9 B;  2XNU A;  4TWD A;  4Z91 A;  2BYS A;  4NZB A;  4ZJS A;  3RIF A;  3WTI A;  4COF A;  3TLS A;  2YN6 A;  4XK9 A;  2BG9 E;  3PEO A;  2BJ0 A;  2XYS A;  5AFK A;  3UU3 A;  2XQ5 A;  2Y57 A;  4UM3 S;  3ZKR A;  4Z90 A;  4TNV A;  5LXB A;  2X00 D;  4ILC A;  5HEH A;  2BR7 A;  3SH1 A;  4ZJT A;  2BYP A;  4UM3 A;  2BYQ A; 
#chains in the Genus database with same CATH topology
 2WNC A;  3LSV A;  2WNJ A;  2XQ4 A;  3WTL A;  5AFJ A;  3UQ4 A;  5HCJ A;  3WTK A;  4QH4 A;  3U8K A;  2XQ6 A;  4D01 A;  5J0Z A;  2XNV A;  5AFL A;  2X00 A;  4ZK4 A;  2ZJU A;  3TLW A;  3UU4 A;  2XZ6 A;  3WTH A;  3UU6 A;  4LMJ A;  3EHZ A;  5HEO A;  4XHE A;  2XQ7 A;  4QH1 A;  5L4H A;  4HFH A;  4ZK1 A;  3GUA A;  3JAE A;  1UX2 A;  3RIA A;  2XNT A;  2YKS A;  4IL4 A;  4F8H A;  3JAF A;  4ILB A;  1UV6 A;  1UW6 A;  3EAM A;  3IGQ A;  3C79 A;  4IL9 A;  2YME A;  3SQ6 A;  5CFB A;  5HEJ A;  3UQ7 A;  4HQP A;  5SYO A;  3ZDH A;  3U8J A;  2BG9 C;  3EI0 A;  2WN9 A;  4HFB A;  3TLV A;  4B5D A;  3RQW A;  3JAD A;  5BRX A;  5IUX A;  2Y7Y A;  2QC1 B;  3U8N A;  3SQ9 A;  4UM3 P;  5HEU A;  4ZRU A;  3ZDG A;  5LG3 A;  2VL0 A;  2Y54 A;  4UXU A;  3RI5 A;  4BFQ A;  4DBM A;  5BP0 A;  4UY2 A;  2BYN A;  5TVC A;  3U8L A;  5AFH A;  4ALX A;  1I9B A;  3T4M A;  2Y56 A;  5HEG A;  5J5H A;  5AIN A;  4QAC A;  4NPP A;  3WTJ A;  4IRE A;  2PH9 A;  2YOE A;  5FJV A;  4HFI A;  2XQ3 A;  2WNL A;  3WTM A;  5CO5 A;  5KE4 A;  2W8F A;  3UU5 A;  3TLU A;  5HCM A;  2BYR A;  4HFD A;  4UM1 A;  3RQU A;  4TWF A;  4A98 A;  4LML A;  2Y58 A;  4FRR A;  2ZJV A;  4TNW A;  3SIO A;  4AFH A;  4HFE A;  3TLT A;  2XQA A;  3U8M A;  2XYT A;  4QAA A;  4ZZC A;  4QAB A;  3UUB A;  5AFM A;  3WTO A;  4EZ1 A;  3PMZ A;  4ZR6 A;  2BG9 A;  4ZZB A;  5J5I A;  5J5F A;  2XQ8 A;  4HFC A;  3P4W A;  4ILA A;  4LMK A;  3C84 A;  2UZ6 A;  4TWH A;  3WIP A;  4AFT A;  4X5T A;  4WV9 A;  4BQT A;  2YMD A;  5JME A;  5AFN A;  3WTN A;  5KZU A;  4A97 A;  5BW2 A;  2XQ9 A;  4QH5 A;  2WZY A;  2XZ5 A;  3P50 A;  2C9T A;  2W8G A;  2PGZ A;  5J5G A;  4AFG A;  5L47 A;  3RHW A;  2BR8 A;  5L4E A;  5AFM B;  3UU8 A;  4PIR A;  2BG9 B;  2XNU A;  4TWD A;  4Z91 A;  2BYS A;  4NZB A;  4ZJS A;  3RIF A;  3WTI A;  4COF A;  3TLS A;  2YN6 A;  4XK9 A;  2BG9 E;  3PEO A;  2BJ0 A;  2XYS A;  5AFK A;  3UU3 A;  2XQ5 A;  2Y57 A;  4UM3 S;  3ZKR A;  4Z90 A;  4TNV A;  5LXB A;  2X00 D;  4ILC A;  5HEH A;  2BR7 A;  3SH1 A;  4ZJT A;  2BYP A;  4UM3 A;  2BYQ A; 
#chains in the Genus database with same CATH homology
 2WNC A;  3LSV A;  2WNJ A;  2XQ4 A;  3WTL A;  5AFJ A;  3UQ4 A;  5HCJ A;  3WTK A;  4QH4 A;  3U8K A;  2XQ6 A;  4D01 A;  5J0Z A;  2XNV A;  5AFL A;  2X00 A;  4ZK4 A;  2ZJU A;  3TLW A;  3UU4 A;  2XZ6 A;  3WTH A;  3UU6 A;  4LMJ A;  3EHZ A;  5HEO A;  4XHE A;  2XQ7 A;  4QH1 A;  5L4H A;  4HFH A;  4ZK1 A;  3GUA A;  3JAE A;  1UX2 A;  3RIA A;  2XNT A;  2YKS A;  4IL4 A;  4F8H A;  3JAF A;  4ILB A;  1UV6 A;  1UW6 A;  3EAM A;  3IGQ A;  3C79 A;  4IL9 A;  2YME A;  3SQ6 A;  5CFB A;  5HEJ A;  3UQ7 A;  4HQP A;  5SYO A;  3ZDH A;  3U8J A;  2BG9 C;  3EI0 A;  2WN9 A;  4HFB A;  3TLV A;  4B5D A;  3RQW A;  3JAD A;  5BRX A;  5IUX A;  2Y7Y A;  2QC1 B;  3U8N A;  3SQ9 A;  4UM3 P;  5HEU A;  4ZRU A;  3ZDG A;  5LG3 A;  2VL0 A;  2Y54 A;  4UXU A;  3RI5 A;  4BFQ A;  4DBM A;  5BP0 A;  4UY2 A;  2BYN A;  5TVC A;  3U8L A;  5AFH A;  4ALX A;  1I9B A;  3T4M A;  2Y56 A;  5HEG A;  5J5H A;  5AIN A;  4QAC A;  4NPP A;  3WTJ A;  4IRE A;  2PH9 A;  2YOE A;  5FJV A;  4HFI A;  2XQ3 A;  2WNL A;  3WTM A;  5CO5 A;  5KE4 A;  2W8F A;  3UU5 A;  3TLU A;  5HCM A;  2BYR A;  4HFD A;  4UM1 A;  3RQU A;  4TWF A;  4A98 A;  4LML A;  2Y58 A;  4FRR A;  2ZJV A;  4TNW A;  3SIO A;  4AFH A;  4HFE A;  3TLT A;  2XQA A;  3U8M A;  2XYT A;  4QAA A;  4ZZC A;  4QAB A;  3UUB A;  5AFM A;  3WTO A;  4EZ1 A;  3PMZ A;  4ZR6 A;  2BG9 A;  4ZZB A;  5J5I A;  5J5F A;  2XQ8 A;  4HFC A;  3P4W A;  4ILA A;  4LMK A;  3C84 A;  2UZ6 A;  4TWH A;  3WIP A;  4AFT A;  4X5T A;  4WV9 A;  4BQT A;  2YMD A;  5JME A;  5AFN A;  3WTN A;  5KZU A;  4A97 A;  5BW2 A;  2XQ9 A;  4QH5 A;  2WZY A;  2XZ5 A;  3P50 A;  2C9T A;  2W8G A;  2PGZ A;  5J5G A;  4AFG A;  5L47 A;  3RHW A;  2BR8 A;  5L4E A;  5AFM B;  3UU8 A;  4PIR A;  2BG9 B;  2XNU A;  4TWD A;  4Z91 A;  2BYS A;  4NZB A;  4ZJS A;  3RIF A;  3WTI A;  4COF A;  3TLS A;  2YN6 A;  4XK9 A;  2BG9 E;  3PEO A;  2BJ0 A;  2XYS A;  5AFK A;  3UU3 A;  2XQ5 A;  2Y57 A;  4UM3 S;  3ZKR A;  4Z90 A;  4TNV A;  5LXB A;  2X00 D;  4ILC A;  5HEH A;  2BR7 A;  3SH1 A;  4ZJT A;  2BYP A;  4UM3 A;  2BYQ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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