3U8MA

Crystal structure of the acetylcholine binding protein (achbp) from lymnaea stagnalis in complex with ns3920 (1-(6-bromopyridin-3-yl)-1,4-diazepane)
Total Genus 49
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
49
sequence length
206
structure length
202
Chain Sequence
LDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLARVVSDGEVLYMPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTDDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKGR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Intersubunit bridge formation governs agonist efficacy at nicotinic acetylcholine alpha 4 beta 2 receptors: unique role of halogen bonding revealed.
pubmed doi rcsb
molecule tags Acetylcholine-binding protein/agonist
source organism Lymnaea stagnalis
molecule keywords Acetylcholine-binding protein
total genus 49
structure length 202
sequence length 206
chains with identical sequence B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T
ec nomenclature
pdb deposition date 2011-10-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02931 Neur_chan_LBD Neurotransmitter-gated ion-channel ligand binding domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.170.10 Mainly Beta Distorted Sandwich Acetylcholine Binding Protein; Chain: A, Neurotransmitter-gated ion-channel ligand-binding domain 3u8mA00
2XNTA 4ILAA 2ZJVA 2BYNA 3EAMA 3T4MA 3WTJA 5J5HA 3RI5A 5IUXA 3ZDGA 5L4EA 2WNLA 2Y58A 4UM1A 4NPPA 2WNCA 2XQ3A 2ZJUA 4LMJA 2XQ6A 4UXUA 5LG3A 2XQ5A 4HQPA 2BYQA 4LMLA 2BG9A 2BYPA 3RQUA 4D01A 5HEOA 4ZR6A 4COFA 2XQ9A 4ZZBA 3RHWA 3UU3A 2XYTA 3SQ6A 3C79A 2BYSA 4UM3A 5AFJA 2YN6A 5KZUA 4Z91A 3RIAA 3TLWA 2W8GA 2XNVA 3WTLA 3WTOA 2W8FA 2BG9B 4TWFA 5BP0A 4IREA 5L4HA 3UU6A 5AINA 2XQAA 2QC1B 4X5TA 3UU5A 4UM3P 5J5FA 2Y56A 5SYOA 4TWHA 4DBMA 4QH5A 4ILCA 3U8KA 4PIRA 3TLVA 4XK9A 2UZ6A 3RIFA 3UU8A 4AFTA 4IL4A 4XHEA 3SH1A 4TNVA 3PMZA 5AFKA 3EHZA 2BR8A 4LMKA 3JAEA 4TNWA 4BFQA 4ZZCA 3WTKA 2X00A 3JADA 1UW6A 3U8LA 2WNJA 2BYRA 2C9TA 4ZRUA 4EZ1A 2BR7A 5J0ZA 3SQ9A 5HEJA 4ZJTA 2XYSA 3UQ7A 5J5IA 2YOEA 4ZJSA 2WN9A 1UV6A 2XQ4A 2BG9E 5HCMA 4IL9A 4HFEA 4UM3S 4QACA 4HFDA 2BJ0A 2YKSA 3UQ4A 3WTIA 3JAFA 2BG9C 3U8JA 3U8MA 4A98A 1I9BA 4QAAA 5AFHA 3UUBA 5HEGA 2XQ7A 4ZK4A 3SIOA 3ZDHA 2Y57A 4NZBA 5BW2A 4HFBA 2XNUA 5TVCA 5AFNA 2VL0A 4HFCA 5HEUA 4F8HA 4QH4A 2WZYA 5HCJA 2PGZA 5JMEA 3P4WA 4UY2A 3ZKRA 3C84A 2PH9A 4HFIA 2Y7YA 5J5GA 5KE4A 5AFMA 4Z90A 3RQWA 5BRXA 3LSVA 4QABA 2YMDA 3U8NA 2YMEA 2Y54A 4ALXA 3TLUA 4ILBA 4B5DA 5LXBA 4AFGA 4FRRA 4BQTA 3WIPA 2X00D 4A97A 3TLSA 3TLTA 3P50A 3WTMA 3EI0A 2XZ5A 3WTNA 4HFHA 2XZ6A 5CFBA 3PEOA 4ZK1A 5AFMB 5HEHA 2XQ8A 3GUAA 5CO5A 3UU4A 4QH1A 5AFLA 4AFHA 1UX2A 3WTHA 4TWDA 5L47A 4WV9A 3IGQA 5FJVA
chains in the Genus database with same CATH superfamily
2XNTA 4ILAA 2ZJVA 2BYNA 3EAMA 3T4MA 3WTJA 5J5HA 3RI5A 5IUXA 3ZDGA 5L4EA 2WNLA 2Y58A 4UM1A 4NPPA 2WNCA 2XQ3A 2ZJUA 4LMJA 2XQ6A 4UXUA 5LG3A 2XQ5A 4HQPA 2BYQA 4LMLA 2BG9A 2BYPA 3RQUA 4D01A 5HEOA 4ZR6A 4COFA 2XQ9A 4ZZBA 3RHWA 3UU3A 2XYTA 3SQ6A 3C79A 2BYSA 4UM3A 5AFJA 2YN6A 5KZUA 4Z91A 3RIAA 3TLWA 2W8GA 2XNVA 3WTLA 3WTOA 2W8FA 2BG9B 4TWFA 5BP0A 4IREA 5L4HA 3UU6A 5AINA 2XQAA 2QC1B 4X5TA 3UU5A 4UM3P 5J5FA 2Y56A 5SYOA 4TWHA 4DBMA 4QH5A 4ILCA 3U8KA 4PIRA 3TLVA 4XK9A 2UZ6A 3RIFA 3UU8A 4AFTA 4IL4A 4XHEA 3SH1A 4TNVA 3PMZA 5AFKA 3EHZA 2BR8A 4LMKA 3JAEA 4TNWA 4BFQA 4ZZCA 3WTKA 2X00A 3JADA 1UW6A 3U8LA 2WNJA 2BYRA 2C9TA 4ZRUA 4EZ1A 2BR7A 5J0ZA 3SQ9A 5HEJA 4ZJTA 2XYSA 3UQ7A 5J5IA 2YOEA 4ZJSA 2WN9A 1UV6A 2XQ4A 2BG9E 5HCMA 4IL9A 4HFEA 4UM3S 4QACA 4HFDA 2BJ0A 2YKSA 3UQ4A 3WTIA 3JAFA 2BG9C 3U8JA 3U8MA 4A98A 1I9BA 4QAAA 5AFHA 3UUBA 5HEGA 2XQ7A 4ZK4A 3SIOA 3ZDHA 2Y57A 4NZBA 5BW2A 4HFBA 2XNUA 5TVCA 5AFNA 2VL0A 4HFCA 5HEUA 4F8HA 4QH4A 2WZYA 5HCJA 2PGZA 5JMEA 3P4WA 4UY2A 3ZKRA 3C84A 2PH9A 4HFIA 2Y7YA 5J5GA 5KE4A 5AFMA 4Z90A 3RQWA 5BRXA 3LSVA 4QABA 2YMDA 3U8NA 2YMEA 2Y54A 4ALXA 3TLUA 4ILBA 4B5DA 5LXBA 4AFGA 4FRRA 4BQTA 3WIPA 2X00D 4A97A 3TLSA 3TLTA 3P50A 3WTMA 3EI0A 2XZ5A 3WTNA 4HFHA 2XZ6A 5CFBA 3PEOA 4ZK1A 5AFMB 5HEHA 2XQ8A 3GUAA 5CO5A 3UU4A 4QH1A 5AFLA 4AFHA 1UX2A 3WTHA 4TWDA 5L47A 4WV9A 3IGQA 5FJVA
chains in the Genus database with same CATH topology
2XNTA 4ILAA 2ZJVA 2BYNA 3EAMA 3T4MA 3WTJA 5J5HA 3RI5A 5IUXA 3ZDGA 5L4EA 2WNLA 2Y58A 4UM1A 4NPPA 2WNCA 2XQ3A 2ZJUA 4LMJA 2XQ6A 4UXUA 5LG3A 2XQ5A 4HQPA 2BYQA 4LMLA 2BG9A 2BYPA 3RQUA 4D01A 5HEOA 4ZR6A 4COFA 2XQ9A 4ZZBA 3RHWA 3UU3A 2XYTA 3SQ6A 3C79A 2BYSA 4UM3A 5AFJA 2YN6A 5KZUA 4Z91A 3RIAA 3TLWA 2W8GA 2XNVA 3WTLA 3WTOA 2W8FA 2BG9B 4TWFA 5BP0A 4IREA 5L4HA 3UU6A 5AINA 2XQAA 2QC1B 4X5TA 3UU5A 4UM3P 5J5FA 2Y56A 5SYOA 4TWHA 4DBMA 4QH5A 4ILCA 3U8KA 4PIRA 3TLVA 4XK9A 2UZ6A 3RIFA 3UU8A 4AFTA 4IL4A 4XHEA 3SH1A 4TNVA 3PMZA 5AFKA 3EHZA 2BR8A 4LMKA 3JAEA 4TNWA 4BFQA 4ZZCA 3WTKA 2X00A 3JADA 1UW6A 3U8LA 2WNJA 2BYRA 2C9TA 4ZRUA 4EZ1A 2BR7A 5J0ZA 3SQ9A 5HEJA 4ZJTA 2XYSA 3UQ7A 5J5IA 2YOEA 4ZJSA 2WN9A 1UV6A 2XQ4A 2BG9E 5HCMA 4IL9A 4HFEA 4UM3S 4QACA 4HFDA 2BJ0A 2YKSA 3UQ4A 3WTIA 3JAFA 2BG9C 3U8JA 3U8MA 4A98A 1I9BA 4QAAA 5AFHA 3UUBA 5HEGA 2XQ7A 4ZK4A 3SIOA 3ZDHA 2Y57A 4NZBA 5BW2A 4HFBA 2XNUA 5TVCA 5AFNA 2VL0A 4HFCA 5HEUA 4F8HA 4QH4A 2WZYA 5HCJA 2PGZA 5JMEA 3P4WA 4UY2A 3ZKRA 3C84A 2PH9A 4HFIA 2Y7YA 5J5GA 5KE4A 5AFMA 4Z90A 3RQWA 5BRXA 3LSVA 4QABA 2YMDA 3U8NA 2YMEA 2Y54A 4ALXA 3TLUA 4ILBA 4B5DA 5LXBA 4AFGA 4FRRA 4BQTA 3WIPA 2X00D 4A97A 3TLSA 3TLTA 3P50A 3WTMA 3EI0A 2XZ5A 3WTNA 4HFHA 2XZ6A 5CFBA 3PEOA 4ZK1A 5AFMB 5HEHA 2XQ8A 3GUAA 5CO5A 3UU4A 4QH1A 5AFLA 4AFHA 1UX2A 3WTHA 4TWDA 5L47A 4WV9A 3IGQA 5FJVA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2XNT A;  4ILA A;  2ZJV A;  2BYN A;  3EAM A;  3T4M A;  3WTJ A;  5J5H A;  3RI5 A;  5IUX A;  3ZDG A;  5L4E A;  2WNL A;  2Y58 A;  4UM1 A;  4NPP A;  2WNC A;  2XQ3 A;  2ZJU A;  4LMJ A;  2XQ6 A;  4UXU A;  5LG3 A;  2XQ5 A;  4HQP A;  2BYQ A;  4LML A;  2BG9 A;  2BYP A;  3RQU A;  4D01 A;  5HEO A;  4ZR6 A;  4COF A;  2XQ9 A;  4ZZB A;  3RHW A;  3UU3 A;  2XYT A;  3SQ6 A;  3C79 A;  2BYS A;  4UM3 A;  5AFJ A;  2YN6 A;  5KZU A;  4Z91 A;  3RIA A;  3TLW A;  2W8G A;  2XNV A;  3WTL A;  3WTO A;  2W8F A;  2BG9 B;  4TWF A;  5BP0 A;  4IRE A;  5L4H A;  3UU6 A;  5AIN A;  2XQA A;  2QC1 B;  4X5T A;  3UU5 A;  4UM3 P;  5J5F A;  2Y56 A;  5SYO A;  4TWH A;  4DBM A;  4QH5 A;  4ILC A;  3U8K A;  4PIR A;  3TLV A;  4XK9 A;  2UZ6 A;  3RIF A;  3UU8 A;  4AFT A;  4IL4 A;  4XHE A;  3SH1 A;  4TNV A;  3PMZ A;  5AFK A;  3EHZ A;  2BR8 A;  4LMK A;  3JAE A;  4TNW A;  4BFQ A;  4ZZC A;  3WTK A;  2X00 A;  3JAD A;  1UW6 A;  3U8L A;  2WNJ A;  2BYR A;  2C9T A;  4ZRU A;  4EZ1 A;  2BR7 A;  5J0Z A;  3SQ9 A;  5HEJ A;  4ZJT A;  2XYS A;  3UQ7 A;  5J5I A;  2YOE A;  4ZJS A;  2WN9 A;  1UV6 A;  2XQ4 A;  2BG9 E;  5HCM A;  4IL9 A;  4HFE A;  4UM3 S;  4QAC A;  4HFD A;  2BJ0 A;  2YKS A;  3UQ4 A;  3WTI A;  3JAF A;  2BG9 C;  3U8J A;  3U8M A;  4A98 A;  1I9B A;  4QAA A;  5AFH A;  3UUB A;  5HEG A;  2XQ7 A;  4ZK4 A;  3SIO A;  3ZDH A;  2Y57 A;  4NZB A;  5BW2 A;  4HFB A;  2XNU A;  5TVC A;  5AFN A;  2VL0 A;  4HFC A;  5HEU A;  4F8H A;  4QH4 A;  2WZY A;  5HCJ A;  2PGZ A;  5JME A;  3P4W A;  4UY2 A;  3ZKR A;  3C84 A;  2PH9 A;  4HFI A;  2Y7Y A;  5J5G A;  5KE4 A;  5AFM A;  4Z90 A;  3RQW A;  5BRX A;  3LSV A;  4QAB A;  2YMD A;  3U8N A;  2YME A;  2Y54 A;  4ALX A;  3TLU A;  4ILB A;  4B5D A;  5LXB A;  4AFG A;  4FRR A;  4BQT A;  3WIP A;  2X00 D;  4A97 A;  3TLS A;  3TLT A;  3P50 A;  3WTM A;  3EI0 A;  2XZ5 A;  3WTN A;  4HFH A;  2XZ6 A;  5CFB A;  3PEO A;  4ZK1 A;  5AFM B;  5HEH A;  2XQ8 A;  3GUA A;  5CO5 A;  3UU4 A;  4QH1 A;  5AFL A;  4AFH A;  1UX2 A;  3WTH A;  4TWD A;  5L47 A;  4WV9 A;  3IGQ A;  5FJV A; 
#chains in the Genus database with same CATH topology
 2XNT A;  4ILA A;  2ZJV A;  2BYN A;  3EAM A;  3T4M A;  3WTJ A;  5J5H A;  3RI5 A;  5IUX A;  3ZDG A;  5L4E A;  2WNL A;  2Y58 A;  4UM1 A;  4NPP A;  2WNC A;  2XQ3 A;  2ZJU A;  4LMJ A;  2XQ6 A;  4UXU A;  5LG3 A;  2XQ5 A;  4HQP A;  2BYQ A;  4LML A;  2BG9 A;  2BYP A;  3RQU A;  4D01 A;  5HEO A;  4ZR6 A;  4COF A;  2XQ9 A;  4ZZB A;  3RHW A;  3UU3 A;  2XYT A;  3SQ6 A;  3C79 A;  2BYS A;  4UM3 A;  5AFJ A;  2YN6 A;  5KZU A;  4Z91 A;  3RIA A;  3TLW A;  2W8G A;  2XNV A;  3WTL A;  3WTO A;  2W8F A;  2BG9 B;  4TWF A;  5BP0 A;  4IRE A;  5L4H A;  3UU6 A;  5AIN A;  2XQA A;  2QC1 B;  4X5T A;  3UU5 A;  4UM3 P;  5J5F A;  2Y56 A;  5SYO A;  4TWH A;  4DBM A;  4QH5 A;  4ILC A;  3U8K A;  4PIR A;  3TLV A;  4XK9 A;  2UZ6 A;  3RIF A;  3UU8 A;  4AFT A;  4IL4 A;  4XHE A;  3SH1 A;  4TNV A;  3PMZ A;  5AFK A;  3EHZ A;  2BR8 A;  4LMK A;  3JAE A;  4TNW A;  4BFQ A;  4ZZC A;  3WTK A;  2X00 A;  3JAD A;  1UW6 A;  3U8L A;  2WNJ A;  2BYR A;  2C9T A;  4ZRU A;  4EZ1 A;  2BR7 A;  5J0Z A;  3SQ9 A;  5HEJ A;  4ZJT A;  2XYS A;  3UQ7 A;  5J5I A;  2YOE A;  4ZJS A;  2WN9 A;  1UV6 A;  2XQ4 A;  2BG9 E;  5HCM A;  4IL9 A;  4HFE A;  4UM3 S;  4QAC A;  4HFD A;  2BJ0 A;  2YKS A;  3UQ4 A;  3WTI A;  3JAF A;  2BG9 C;  3U8J A;  3U8M A;  4A98 A;  1I9B A;  4QAA A;  5AFH A;  3UUB A;  5HEG A;  2XQ7 A;  4ZK4 A;  3SIO A;  3ZDH A;  2Y57 A;  4NZB A;  5BW2 A;  4HFB A;  2XNU A;  5TVC A;  5AFN A;  2VL0 A;  4HFC A;  5HEU A;  4F8H A;  4QH4 A;  2WZY A;  5HCJ A;  2PGZ A;  5JME A;  3P4W A;  4UY2 A;  3ZKR A;  3C84 A;  2PH9 A;  4HFI A;  2Y7Y A;  5J5G A;  5KE4 A;  5AFM A;  4Z90 A;  3RQW A;  5BRX A;  3LSV A;  4QAB A;  2YMD A;  3U8N A;  2YME A;  2Y54 A;  4ALX A;  3TLU A;  4ILB A;  4B5D A;  5LXB A;  4AFG A;  4FRR A;  4BQT A;  3WIP A;  2X00 D;  4A97 A;  3TLS A;  3TLT A;  3P50 A;  3WTM A;  3EI0 A;  2XZ5 A;  3WTN A;  4HFH A;  2XZ6 A;  5CFB A;  3PEO A;  4ZK1 A;  5AFM B;  5HEH A;  2XQ8 A;  3GUA A;  5CO5 A;  3UU4 A;  4QH1 A;  5AFL A;  4AFH A;  1UX2 A;  3WTH A;  4TWD A;  5L47 A;  4WV9 A;  3IGQ A;  5FJV A; 
#chains in the Genus database with same CATH homology
 2XNT A;  4ILA A;  2ZJV A;  2BYN A;  3EAM A;  3T4M A;  3WTJ A;  5J5H A;  3RI5 A;  5IUX A;  3ZDG A;  5L4E A;  2WNL A;  2Y58 A;  4UM1 A;  4NPP A;  2WNC A;  2XQ3 A;  2ZJU A;  4LMJ A;  2XQ6 A;  4UXU A;  5LG3 A;  2XQ5 A;  4HQP A;  2BYQ A;  4LML A;  2BG9 A;  2BYP A;  3RQU A;  4D01 A;  5HEO A;  4ZR6 A;  4COF A;  2XQ9 A;  4ZZB A;  3RHW A;  3UU3 A;  2XYT A;  3SQ6 A;  3C79 A;  2BYS A;  4UM3 A;  5AFJ A;  2YN6 A;  5KZU A;  4Z91 A;  3RIA A;  3TLW A;  2W8G A;  2XNV A;  3WTL A;  3WTO A;  2W8F A;  2BG9 B;  4TWF A;  5BP0 A;  4IRE A;  5L4H A;  3UU6 A;  5AIN A;  2XQA A;  2QC1 B;  4X5T A;  3UU5 A;  4UM3 P;  5J5F A;  2Y56 A;  5SYO A;  4TWH A;  4DBM A;  4QH5 A;  4ILC A;  3U8K A;  4PIR A;  3TLV A;  4XK9 A;  2UZ6 A;  3RIF A;  3UU8 A;  4AFT A;  4IL4 A;  4XHE A;  3SH1 A;  4TNV A;  3PMZ A;  5AFK A;  3EHZ A;  2BR8 A;  4LMK A;  3JAE A;  4TNW A;  4BFQ A;  4ZZC A;  3WTK A;  2X00 A;  3JAD A;  1UW6 A;  3U8L A;  2WNJ A;  2BYR A;  2C9T A;  4ZRU A;  4EZ1 A;  2BR7 A;  5J0Z A;  3SQ9 A;  5HEJ A;  4ZJT A;  2XYS A;  3UQ7 A;  5J5I A;  2YOE A;  4ZJS A;  2WN9 A;  1UV6 A;  2XQ4 A;  2BG9 E;  5HCM A;  4IL9 A;  4HFE A;  4UM3 S;  4QAC A;  4HFD A;  2BJ0 A;  2YKS A;  3UQ4 A;  3WTI A;  3JAF A;  2BG9 C;  3U8J A;  3U8M A;  4A98 A;  1I9B A;  4QAA A;  5AFH A;  3UUB A;  5HEG A;  2XQ7 A;  4ZK4 A;  3SIO A;  3ZDH A;  2Y57 A;  4NZB A;  5BW2 A;  4HFB A;  2XNU A;  5TVC A;  5AFN A;  2VL0 A;  4HFC A;  5HEU A;  4F8H A;  4QH4 A;  2WZY A;  5HCJ A;  2PGZ A;  5JME A;  3P4W A;  4UY2 A;  3ZKR A;  3C84 A;  2PH9 A;  4HFI A;  2Y7Y A;  5J5G A;  5KE4 A;  5AFM A;  4Z90 A;  3RQW A;  5BRX A;  3LSV A;  4QAB A;  2YMD A;  3U8N A;  2YME A;  2Y54 A;  4ALX A;  3TLU A;  4ILB A;  4B5D A;  5LXB A;  4AFG A;  4FRR A;  4BQT A;  3WIP A;  2X00 D;  4A97 A;  3TLS A;  3TLT A;  3P50 A;  3WTM A;  3EI0 A;  2XZ5 A;  3WTN A;  4HFH A;  2XZ6 A;  5CFB A;  3PEO A;  4ZK1 A;  5AFM B;  5HEH A;  2XQ8 A;  3GUA A;  5CO5 A;  3UU4 A;  4QH1 A;  5AFL A;  4AFH A;  1UX2 A;  3WTH A;  4TWD A;  5L47 A;  4WV9 A;  3IGQ A;  5FJV A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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