3U8NA

Crystal structure of the acetylcholine binding protein (achbp) from lymnaea stagnalis in complex with ns3950 (1-(6-bromo-5-ethoxypyridin-3-yl)-1,4-diazepane)
Total Genus 49
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
49
sequence length
205
structure length
202
Chain Sequence
LDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLARVVSDGEVLYMPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTTDDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Acetylcholine-binding protein/agonist
source organism Lymnaea stagnalis
publication title Intersubunit bridge formation governs agonist efficacy at nicotinic acetylcholine alpha 4 beta 2 receptors: unique role of halogen bonding revealed.
pubmed doi rcsb
molecule keywords Acetylcholine-binding protein
total genus 49
structure length 202
sequence length 205
chains with identical sequence B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T
ec nomenclature
pdb deposition date 2011-10-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02931 Neur_chan_LBD Neurotransmitter-gated ion-channel ligand binding domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.170.10 Mainly Beta Distorted Sandwich Acetylcholine Binding Protein; Chain: A, Neurotransmitter-gated ion-channel ligand-binding domain 3u8nA00
5AFHA 4AFTA 5CFBA 3PEOA 3RI5A 4UM3A 3WTLA 3WTOA 2BYQA 4HFDA 3U8NA 1I9BA 5HEOA 2XQ9A 3P4WA 3SIOA 2XYTA 4BQTA 5BRXA 2XNVA 1UW6A 2XQ4A 5AFLA 4LMJA 4EZ1A 2YN6A 5HEUA 4COFA 4QH5A 2XNUA 3TLSA 4Z91A 3U8LA 3UQ4A 2BJ0A 2BYSA 3UU8A 5KE4A 4TWHA 4ZK4A 2BG9A 5BW2A 4IL9A 4UY2A 2XQ5A 3UQ7A 4UM3S 4B5DA 2ZJVA 5KZUA 4DBMA 5L4EA 2WNCA 3EI0A 4QABA 2VL0A 4QAAA 3UUBA 4AFHA 2Y7YA 2X00D 3UU4A 4IREA 5CO5A 5TVCA 4A97A 2XQ3A 4HQPA 3RIAA 3SH1A 3WIPA 5BP0A 3C84A 3WTIA 3RQWA 2XQ6A 3P50A 3U8JA 2BG9C 5FJVA 3UU5A 3JADA 4HFIA 3RIFA 4PIRA 4WV9A 1UX2A 3ZKRA 4HFEA 4LMKA 4LMLA 2XNTA 4NZBA 1UV6A 4UM1A 5L47A 5J5GA 3UU6A 2BYRA 2Y57A 4X5TA 5IUXA 3T4MA 3RQUA 5AINA 4IL4A 3PMZA 4HFHA 3TLUA 5LG3A 3ZDGA 4ZZCA 3ZDHA 3TLVA 4ZR6A 3JAEA 4ZZBA 5SYOA 2WZYA 3WTMA 3RHWA 2ZJUA 5AFMB 5AFKA 3C79A 2XQ7A 3GUAA 5HEJA 2BR7A 2BR8A 5HCMA 2Y58A 4HFCA 4NPPA 2XZ5A 3EHZA 4ZJSA 2Y56A 4AFGA 2XQ8A 2BYNA 4ALXA 4ZJTA 5JMEA 5J0ZA 4QH4A 2WNLA 5J5HA 2XYSA 3IGQA 3U8MA 4XK9A 5L4HA 4ILAA 2YOEA 2X00A 4ZRUA 5HCJA 5AFJA 5LXBA 5HEGA 4QACA 2XQAA 2YMEA 3SQ6A 4HFBA 5AFMA 4XHEA 4FRRA 2YMDA 3EAMA 3UU3A 3WTHA 4F8HA 3SQ9A 4ZK1A 4TNWA 4TWDA 3TLWA 4D01A 2YKSA 4A98A 4QH1A 2BYPA 2PGZA 2PH9A 4ILBA 4Z90A 4TNVA 4TWFA 3LSVA 2BG9E 3WTJA 2WN9A 4UM3P 2WNJA 3TLTA 2W8GA 2UZ6A 3JAFA 4ILCA 3U8KA 3WTKA 4BFQA 5AFNA 2Y54A 5HEHA 2QC1B 4UXUA 2C9TA 3WTNA 2W8FA 5J5FA 5J5IA 2XZ6A 2BG9B
chains in the Genus database with same CATH superfamily
5AFHA 4AFTA 5CFBA 3PEOA 3RI5A 4UM3A 3WTLA 3WTOA 2BYQA 4HFDA 3U8NA 1I9BA 5HEOA 2XQ9A 3P4WA 3SIOA 2XYTA 4BQTA 5BRXA 2XNVA 1UW6A 2XQ4A 5AFLA 4LMJA 4EZ1A 2YN6A 5HEUA 4COFA 4QH5A 2XNUA 3TLSA 4Z91A 3U8LA 3UQ4A 2BJ0A 2BYSA 3UU8A 5KE4A 4TWHA 4ZK4A 2BG9A 5BW2A 4IL9A 4UY2A 2XQ5A 3UQ7A 4UM3S 4B5DA 2ZJVA 5KZUA 4DBMA 5L4EA 2WNCA 3EI0A 4QABA 2VL0A 4QAAA 3UUBA 4AFHA 2Y7YA 2X00D 3UU4A 4IREA 5CO5A 5TVCA 4A97A 2XQ3A 4HQPA 3RIAA 3SH1A 3WIPA 5BP0A 3C84A 3WTIA 3RQWA 2XQ6A 3P50A 3U8JA 2BG9C 5FJVA 3UU5A 3JADA 4HFIA 3RIFA 4PIRA 4WV9A 1UX2A 3ZKRA 4HFEA 4LMKA 4LMLA 2XNTA 4NZBA 1UV6A 4UM1A 5L47A 5J5GA 3UU6A 2BYRA 2Y57A 4X5TA 5IUXA 3T4MA 3RQUA 5AINA 4IL4A 3PMZA 4HFHA 3TLUA 5LG3A 3ZDGA 4ZZCA 3ZDHA 3TLVA 4ZR6A 3JAEA 4ZZBA 5SYOA 2WZYA 3WTMA 3RHWA 2ZJUA 5AFMB 5AFKA 3C79A 2XQ7A 3GUAA 5HEJA 2BR7A 2BR8A 5HCMA 2Y58A 4HFCA 4NPPA 2XZ5A 3EHZA 4ZJSA 2Y56A 4AFGA 2XQ8A 2BYNA 4ALXA 4ZJTA 5JMEA 5J0ZA 4QH4A 2WNLA 5J5HA 2XYSA 3IGQA 3U8MA 4XK9A 5L4HA 4ILAA 2YOEA 2X00A 4ZRUA 5HCJA 5AFJA 5LXBA 5HEGA 4QACA 2XQAA 2YMEA 3SQ6A 4HFBA 5AFMA 4XHEA 4FRRA 2YMDA 3EAMA 3UU3A 3WTHA 4F8HA 3SQ9A 4ZK1A 4TNWA 4TWDA 3TLWA 4D01A 2YKSA 4A98A 4QH1A 2BYPA 2PGZA 2PH9A 4ILBA 4Z90A 4TNVA 4TWFA 3LSVA 2BG9E 3WTJA 2WN9A 4UM3P 2WNJA 3TLTA 2W8GA 2UZ6A 3JAFA 4ILCA 3U8KA 3WTKA 4BFQA 5AFNA 2Y54A 5HEHA 2QC1B 4UXUA 2C9TA 3WTNA 2W8FA 5J5FA 5J5IA 2XZ6A 2BG9B
chains in the Genus database with same CATH topology
5AFHA 4AFTA 5CFBA 3PEOA 3RI5A 4UM3A 3WTLA 3WTOA 2BYQA 4HFDA 3U8NA 1I9BA 5HEOA 2XQ9A 3P4WA 3SIOA 2XYTA 4BQTA 5BRXA 2XNVA 1UW6A 2XQ4A 5AFLA 4LMJA 4EZ1A 2YN6A 5HEUA 4COFA 4QH5A 2XNUA 3TLSA 4Z91A 3U8LA 3UQ4A 2BJ0A 2BYSA 3UU8A 5KE4A 4TWHA 4ZK4A 2BG9A 5BW2A 4IL9A 4UY2A 2XQ5A 3UQ7A 4UM3S 4B5DA 2ZJVA 5KZUA 4DBMA 5L4EA 2WNCA 3EI0A 4QABA 2VL0A 4QAAA 3UUBA 4AFHA 2Y7YA 2X00D 3UU4A 4IREA 5CO5A 5TVCA 4A97A 2XQ3A 4HQPA 3RIAA 3SH1A 3WIPA 5BP0A 3C84A 3WTIA 3RQWA 2XQ6A 3P50A 3U8JA 2BG9C 5FJVA 3UU5A 3JADA 4HFIA 3RIFA 4PIRA 4WV9A 1UX2A 3ZKRA 4HFEA 4LMKA 4LMLA 2XNTA 4NZBA 1UV6A 4UM1A 5L47A 5J5GA 3UU6A 2BYRA 2Y57A 4X5TA 5IUXA 3T4MA 3RQUA 5AINA 4IL4A 3PMZA 4HFHA 3TLUA 5LG3A 3ZDGA 4ZZCA 3ZDHA 3TLVA 4ZR6A 3JAEA 4ZZBA 5SYOA 2WZYA 3WTMA 3RHWA 2ZJUA 5AFMB 5AFKA 3C79A 2XQ7A 3GUAA 5HEJA 2BR7A 2BR8A 5HCMA 2Y58A 4HFCA 4NPPA 2XZ5A 3EHZA 4ZJSA 2Y56A 4AFGA 2XQ8A 2BYNA 4ALXA 4ZJTA 5JMEA 5J0ZA 4QH4A 2WNLA 5J5HA 2XYSA 3IGQA 3U8MA 4XK9A 5L4HA 4ILAA 2YOEA 2X00A 4ZRUA 5HCJA 5AFJA 5LXBA 5HEGA 4QACA 2XQAA 2YMEA 3SQ6A 4HFBA 5AFMA 4XHEA 4FRRA 2YMDA 3EAMA 3UU3A 3WTHA 4F8HA 3SQ9A 4ZK1A 4TNWA 4TWDA 3TLWA 4D01A 2YKSA 4A98A 4QH1A 2BYPA 2PGZA 2PH9A 4ILBA 4Z90A 4TNVA 4TWFA 3LSVA 2BG9E 3WTJA 2WN9A 4UM3P 2WNJA 3TLTA 2W8GA 2UZ6A 3JAFA 4ILCA 3U8KA 3WTKA 4BFQA 5AFNA 2Y54A 5HEHA 2QC1B 4UXUA 2C9TA 3WTNA 2W8FA 5J5FA 5J5IA 2XZ6A 2BG9B
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5AFH A;  4AFT A;  5CFB A;  3PEO A;  3RI5 A;  4UM3 A;  3WTL A;  3WTO A;  2BYQ A;  4HFD A;  3U8N A;  1I9B A;  5HEO A;  2XQ9 A;  3P4W A;  3SIO A;  2XYT A;  4BQT A;  5BRX A;  2XNV A;  1UW6 A;  2XQ4 A;  5AFL A;  4LMJ A;  4EZ1 A;  2YN6 A;  5HEU A;  4COF A;  4QH5 A;  2XNU A;  3TLS A;  4Z91 A;  3U8L A;  3UQ4 A;  2BJ0 A;  2BYS A;  3UU8 A;  5KE4 A;  4TWH A;  4ZK4 A;  2BG9 A;  5BW2 A;  4IL9 A;  4UY2 A;  2XQ5 A;  3UQ7 A;  4UM3 S;  4B5D A;  2ZJV A;  5KZU A;  4DBM A;  5L4E A;  2WNC A;  3EI0 A;  4QAB A;  2VL0 A;  4QAA A;  3UUB A;  4AFH A;  2Y7Y A;  2X00 D;  3UU4 A;  4IRE A;  5CO5 A;  5TVC A;  4A97 A;  2XQ3 A;  4HQP A;  3RIA A;  3SH1 A;  3WIP A;  5BP0 A;  3C84 A;  3WTI A;  3RQW A;  2XQ6 A;  3P50 A;  3U8J A;  2BG9 C;  5FJV A;  3UU5 A;  3JAD A;  4HFI A;  3RIF A;  4PIR A;  4WV9 A;  1UX2 A;  3ZKR A;  4HFE A;  4LMK A;  4LML A;  2XNT A;  4NZB A;  1UV6 A;  4UM1 A;  5L47 A;  5J5G A;  3UU6 A;  2BYR A;  2Y57 A;  4X5T A;  5IUX A;  3T4M A;  3RQU A;  5AIN A;  4IL4 A;  3PMZ A;  4HFH A;  3TLU A;  5LG3 A;  3ZDG A;  4ZZC A;  3ZDH A;  3TLV A;  4ZR6 A;  3JAE A;  4ZZB A;  5SYO A;  2WZY A;  3WTM A;  3RHW A;  2ZJU A;  5AFM B;  5AFK A;  3C79 A;  2XQ7 A;  3GUA A;  5HEJ A;  2BR7 A;  2BR8 A;  5HCM A;  2Y58 A;  4HFC A;  4NPP A;  2XZ5 A;  3EHZ A;  4ZJS A;  2Y56 A;  4AFG A;  2XQ8 A;  2BYN A;  4ALX A;  4ZJT A;  5JME A;  5J0Z A;  4QH4 A;  2WNL A;  5J5H A;  2XYS A;  3IGQ A;  3U8M A;  4XK9 A;  5L4H A;  4ILA A;  2YOE A;  2X00 A;  4ZRU A;  5HCJ A;  5AFJ A;  5LXB A;  5HEG A;  4QAC A;  2XQA A;  2YME A;  3SQ6 A;  4HFB A;  5AFM A;  4XHE A;  4FRR A;  2YMD A;  3EAM A;  3UU3 A;  3WTH A;  4F8H A;  3SQ9 A;  4ZK1 A;  4TNW A;  4TWD A;  3TLW A;  4D01 A;  2YKS A;  4A98 A;  4QH1 A;  2BYP A;  2PGZ A;  2PH9 A;  4ILB A;  4Z90 A;  4TNV A;  4TWF A;  3LSV A;  2BG9 E;  3WTJ A;  2WN9 A;  4UM3 P;  2WNJ A;  3TLT A;  2W8G A;  2UZ6 A;  3JAF A;  4ILC A;  3U8K A;  3WTK A;  4BFQ A;  5AFN A;  2Y54 A;  5HEH A;  2QC1 B;  4UXU A;  2C9T A;  3WTN A;  2W8F A;  5J5F A;  5J5I A;  2XZ6 A;  2BG9 B; 
#chains in the Genus database with same CATH topology
 5AFH A;  4AFT A;  5CFB A;  3PEO A;  3RI5 A;  4UM3 A;  3WTL A;  3WTO A;  2BYQ A;  4HFD A;  3U8N A;  1I9B A;  5HEO A;  2XQ9 A;  3P4W A;  3SIO A;  2XYT A;  4BQT A;  5BRX A;  2XNV A;  1UW6 A;  2XQ4 A;  5AFL A;  4LMJ A;  4EZ1 A;  2YN6 A;  5HEU A;  4COF A;  4QH5 A;  2XNU A;  3TLS A;  4Z91 A;  3U8L A;  3UQ4 A;  2BJ0 A;  2BYS A;  3UU8 A;  5KE4 A;  4TWH A;  4ZK4 A;  2BG9 A;  5BW2 A;  4IL9 A;  4UY2 A;  2XQ5 A;  3UQ7 A;  4UM3 S;  4B5D A;  2ZJV A;  5KZU A;  4DBM A;  5L4E A;  2WNC A;  3EI0 A;  4QAB A;  2VL0 A;  4QAA A;  3UUB A;  4AFH A;  2Y7Y A;  2X00 D;  3UU4 A;  4IRE A;  5CO5 A;  5TVC A;  4A97 A;  2XQ3 A;  4HQP A;  3RIA A;  3SH1 A;  3WIP A;  5BP0 A;  3C84 A;  3WTI A;  3RQW A;  2XQ6 A;  3P50 A;  3U8J A;  2BG9 C;  5FJV A;  3UU5 A;  3JAD A;  4HFI A;  3RIF A;  4PIR A;  4WV9 A;  1UX2 A;  3ZKR A;  4HFE A;  4LMK A;  4LML A;  2XNT A;  4NZB A;  1UV6 A;  4UM1 A;  5L47 A;  5J5G A;  3UU6 A;  2BYR A;  2Y57 A;  4X5T A;  5IUX A;  3T4M A;  3RQU A;  5AIN A;  4IL4 A;  3PMZ A;  4HFH A;  3TLU A;  5LG3 A;  3ZDG A;  4ZZC A;  3ZDH A;  3TLV A;  4ZR6 A;  3JAE A;  4ZZB A;  5SYO A;  2WZY A;  3WTM A;  3RHW A;  2ZJU A;  5AFM B;  5AFK A;  3C79 A;  2XQ7 A;  3GUA A;  5HEJ A;  2BR7 A;  2BR8 A;  5HCM A;  2Y58 A;  4HFC A;  4NPP A;  2XZ5 A;  3EHZ A;  4ZJS A;  2Y56 A;  4AFG A;  2XQ8 A;  2BYN A;  4ALX A;  4ZJT A;  5JME A;  5J0Z A;  4QH4 A;  2WNL A;  5J5H A;  2XYS A;  3IGQ A;  3U8M A;  4XK9 A;  5L4H A;  4ILA A;  2YOE A;  2X00 A;  4ZRU A;  5HCJ A;  5AFJ A;  5LXB A;  5HEG A;  4QAC A;  2XQA A;  2YME A;  3SQ6 A;  4HFB A;  5AFM A;  4XHE A;  4FRR A;  2YMD A;  3EAM A;  3UU3 A;  3WTH A;  4F8H A;  3SQ9 A;  4ZK1 A;  4TNW A;  4TWD A;  3TLW A;  4D01 A;  2YKS A;  4A98 A;  4QH1 A;  2BYP A;  2PGZ A;  2PH9 A;  4ILB A;  4Z90 A;  4TNV A;  4TWF A;  3LSV A;  2BG9 E;  3WTJ A;  2WN9 A;  4UM3 P;  2WNJ A;  3TLT A;  2W8G A;  2UZ6 A;  3JAF A;  4ILC A;  3U8K A;  3WTK A;  4BFQ A;  5AFN A;  2Y54 A;  5HEH A;  2QC1 B;  4UXU A;  2C9T A;  3WTN A;  2W8F A;  5J5F A;  5J5I A;  2XZ6 A;  2BG9 B; 
#chains in the Genus database with same CATH homology
 5AFH A;  4AFT A;  5CFB A;  3PEO A;  3RI5 A;  4UM3 A;  3WTL A;  3WTO A;  2BYQ A;  4HFD A;  3U8N A;  1I9B A;  5HEO A;  2XQ9 A;  3P4W A;  3SIO A;  2XYT A;  4BQT A;  5BRX A;  2XNV A;  1UW6 A;  2XQ4 A;  5AFL A;  4LMJ A;  4EZ1 A;  2YN6 A;  5HEU A;  4COF A;  4QH5 A;  2XNU A;  3TLS A;  4Z91 A;  3U8L A;  3UQ4 A;  2BJ0 A;  2BYS A;  3UU8 A;  5KE4 A;  4TWH A;  4ZK4 A;  2BG9 A;  5BW2 A;  4IL9 A;  4UY2 A;  2XQ5 A;  3UQ7 A;  4UM3 S;  4B5D A;  2ZJV A;  5KZU A;  4DBM A;  5L4E A;  2WNC A;  3EI0 A;  4QAB A;  2VL0 A;  4QAA A;  3UUB A;  4AFH A;  2Y7Y A;  2X00 D;  3UU4 A;  4IRE A;  5CO5 A;  5TVC A;  4A97 A;  2XQ3 A;  4HQP A;  3RIA A;  3SH1 A;  3WIP A;  5BP0 A;  3C84 A;  3WTI A;  3RQW A;  2XQ6 A;  3P50 A;  3U8J A;  2BG9 C;  5FJV A;  3UU5 A;  3JAD A;  4HFI A;  3RIF A;  4PIR A;  4WV9 A;  1UX2 A;  3ZKR A;  4HFE A;  4LMK A;  4LML A;  2XNT A;  4NZB A;  1UV6 A;  4UM1 A;  5L47 A;  5J5G A;  3UU6 A;  2BYR A;  2Y57 A;  4X5T A;  5IUX A;  3T4M A;  3RQU A;  5AIN A;  4IL4 A;  3PMZ A;  4HFH A;  3TLU A;  5LG3 A;  3ZDG A;  4ZZC A;  3ZDH A;  3TLV A;  4ZR6 A;  3JAE A;  4ZZB A;  5SYO A;  2WZY A;  3WTM A;  3RHW A;  2ZJU A;  5AFM B;  5AFK A;  3C79 A;  2XQ7 A;  3GUA A;  5HEJ A;  2BR7 A;  2BR8 A;  5HCM A;  2Y58 A;  4HFC A;  4NPP A;  2XZ5 A;  3EHZ A;  4ZJS A;  2Y56 A;  4AFG A;  2XQ8 A;  2BYN A;  4ALX A;  4ZJT A;  5JME A;  5J0Z A;  4QH4 A;  2WNL A;  5J5H A;  2XYS A;  3IGQ A;  3U8M A;  4XK9 A;  5L4H A;  4ILA A;  2YOE A;  2X00 A;  4ZRU A;  5HCJ A;  5AFJ A;  5LXB A;  5HEG A;  4QAC A;  2XQA A;  2YME A;  3SQ6 A;  4HFB A;  5AFM A;  4XHE A;  4FRR A;  2YMD A;  3EAM A;  3UU3 A;  3WTH A;  4F8H A;  3SQ9 A;  4ZK1 A;  4TNW A;  4TWD A;  3TLW A;  4D01 A;  2YKS A;  4A98 A;  4QH1 A;  2BYP A;  2PGZ A;  2PH9 A;  4ILB A;  4Z90 A;  4TNV A;  4TWF A;  3LSV A;  2BG9 E;  3WTJ A;  2WN9 A;  4UM3 P;  2WNJ A;  3TLT A;  2W8G A;  2UZ6 A;  3JAF A;  4ILC A;  3U8K A;  3WTK A;  4BFQ A;  5AFN A;  2Y54 A;  5HEH A;  2QC1 B;  4UXU A;  2C9T A;  3WTN A;  2W8F A;  5J5F A;  5J5I A;  2XZ6 A;  2BG9 B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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