3SIOA

Ac-achbp ligand binding domain (not including beta 9-10 linker) mutated to human alpha-7 nachr
Total Genus 53
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
53
sequence length
214
structure length
214
Chain Sequence
KDDDDKLHSQANLMRLKSDLFNRSPMYPGPTKDDPLTVYLSFSLLDIVKADSSTNEVDLVYWEQQSWKLNSLMWDPNEYGNITDFRTSAADIWTPDITAYSSTRPVQVLSPQNALVNSSGHVQYLPAQRLSFMCDPTGVDSEEGATCAVKFGSWSYGGWEIDLKTDTDQVDLSSYYASSKYEILSATQTRQVQHYSCCPEPYIDVNLVVKFRER
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Receptor
source organism Aplysia californica
publication title Creating an alpha-7 nicotinic acetylcholine recognition domain from the acetylcholine binding protein: crystallographic and ligand selectivity analyses
pubmed doi rcsb
molecule keywords Soluble acetylcholine receptor
total genus 53
structure length 214
sequence length 214
chains with identical sequence B, C, D, E, F, G, H, I, J
ec nomenclature
pdb deposition date 2011-06-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02931 Neur_chan_LBD Neurotransmitter-gated ion-channel ligand binding domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.170.10 Mainly Beta Distorted Sandwich Acetylcholine Binding Protein; Chain: A, Neurotransmitter-gated ion-channel ligand-binding domain 3sioA00
2BG9A 2BG9B 5AFNA 1UX2A 4UM3A 2WNLA 2XZ6A 2YMDA 4HQPA 2PGZA 4NPPA 3WTMA 4ZZCA 3EHZA 3UU4A 4LMKA 2ZJUA 4TWDA 1I9BA 4B5DA 5L4HA 4XK9A 3U8JA 5AFLA 3RQUA 2BYQA 2BG9C 5SYOA 4IREA 3U8LA 3EI0A 3U8KA 5HCJA 5L4EA 3WTJA 3JAEA 4AFGA 4ZJTA 2VL0A 2XNTA 3WIPA 3TLSA 3ZKRA 3RHWA 4BQTA 3UQ7A 5CFBA 4ILAA 4QAAA 3SQ9A 4QH1A 4F8HA 5HEUA 4DBMA 4IL4A 4QH5A 4WV9A 3WTLA 5FJVA 4LMJA 4QH4A 5L47A 3C79A 4NZBA 4HFBA 3U8MA 5J5IA 2BR7A 3UU8A 3UQ4A 3EAMA 2XQ5A 2XYSA 4ZZBA 2YN6A 4XHEA 2XNUA 2BJ0A 2XQ4A 4Z90A 3WTNA 2W8FA 4PIRA 2WNJA 4HFIA 3SH1A 4HFHA 5HEOA 3SIOA 3P4WA 2YMEA 5LG3A 5KZUA 2WNCA 2XQ7A 3IGQA 2BR8A 4HFDA 2UZ6A 4UY2A 2Y54A 5BRXA 2XQAA 3TLTA 4ALXA 2W8GA 2ZJVA 5HEJA 4ZJSA 5AFMA 5AFKA 5AFMB 3LSVA 3RIAA 4UXUA 3PEOA 2X00D 2XNVA 4TWFA 5J5HA 3P50A 5BP0A 4HFEA 5J5GA 3RQWA 3UUBA 3WTKA 3JADA 4ZRUA 2BYNA 4ZK4A 4BFQA 2Y56A 5AFJA 3ZDHA 4Z91A 3UU3A 2XQ8A 2BYRA 2XZ5A 4TNVA 5HEHA 5AFHA 2X00A 4X5TA 3ZDGA 3GUAA 4A97A 2WZYA 4ZR6A 2BYSA 1UW6A 4IL9A 2Y7YA 4AFTA 3C84A 1UV6A 5AINA 3PMZA 5TVCA 5J0ZA 5HCMA 5J5FA 4UM3S 5LXBA 2QC1B 3SQ6A 4A98A 3JAFA 4QABA 2XQ9A 3WTIA 4AFHA 4FRRA 2PH9A 2C9TA 4COFA 5CO5A 3T4MA 4UM1A 3TLUA 4ZK1A 2XQ6A 3RI5A 2Y57A 4D01A 4QACA 3TLVA 3U8NA 2XQ3A 3UU5A 3WTOA 4TWHA 2XYTA 2BG9E 4ILCA 5IUXA 2WN9A 4HFCA 5JMEA 4LMLA 5HEGA 5BW2A 3TLWA 2Y58A 5KE4A 3UU6A 2BYPA 4UM3P 2YOEA 4EZ1A 2YKSA 4ILBA 4TNWA 3WTHA 3RIFA
chains in the Genus database with same CATH superfamily
2BG9A 2BG9B 5AFNA 1UX2A 4UM3A 2WNLA 2XZ6A 2YMDA 4HQPA 2PGZA 4NPPA 3WTMA 4ZZCA 3EHZA 3UU4A 4LMKA 2ZJUA 4TWDA 1I9BA 4B5DA 5L4HA 4XK9A 3U8JA 5AFLA 3RQUA 2BYQA 2BG9C 5SYOA 4IREA 3U8LA 3EI0A 3U8KA 5HCJA 5L4EA 3WTJA 3JAEA 4AFGA 4ZJTA 2VL0A 2XNTA 3WIPA 3TLSA 3ZKRA 3RHWA 4BQTA 3UQ7A 5CFBA 4ILAA 4QAAA 3SQ9A 4QH1A 4F8HA 5HEUA 4DBMA 4IL4A 4QH5A 4WV9A 3WTLA 5FJVA 4LMJA 4QH4A 5L47A 3C79A 4NZBA 4HFBA 3U8MA 5J5IA 2BR7A 3UU8A 3UQ4A 3EAMA 2XQ5A 2XYSA 4ZZBA 2YN6A 4XHEA 2XNUA 2BJ0A 2XQ4A 4Z90A 3WTNA 2W8FA 4PIRA 2WNJA 4HFIA 3SH1A 4HFHA 5HEOA 3SIOA 3P4WA 2YMEA 5LG3A 5KZUA 2WNCA 2XQ7A 3IGQA 2BR8A 4HFDA 2UZ6A 4UY2A 2Y54A 5BRXA 2XQAA 3TLTA 4ALXA 2W8GA 2ZJVA 5HEJA 4ZJSA 5AFMA 5AFKA 5AFMB 3LSVA 3RIAA 4UXUA 3PEOA 2X00D 2XNVA 4TWFA 5J5HA 3P50A 5BP0A 4HFEA 5J5GA 3RQWA 3UUBA 3WTKA 3JADA 4ZRUA 2BYNA 4ZK4A 4BFQA 2Y56A 5AFJA 3ZDHA 4Z91A 3UU3A 2XQ8A 2BYRA 2XZ5A 4TNVA 5HEHA 5AFHA 2X00A 4X5TA 3ZDGA 3GUAA 4A97A 2WZYA 4ZR6A 2BYSA 1UW6A 4IL9A 2Y7YA 4AFTA 3C84A 1UV6A 5AINA 3PMZA 5TVCA 5J0ZA 5HCMA 5J5FA 4UM3S 5LXBA 2QC1B 3SQ6A 4A98A 3JAFA 4QABA 2XQ9A 3WTIA 4AFHA 4FRRA 2PH9A 2C9TA 4COFA 5CO5A 3T4MA 4UM1A 3TLUA 4ZK1A 2XQ6A 3RI5A 2Y57A 4D01A 4QACA 3TLVA 3U8NA 2XQ3A 3UU5A 3WTOA 4TWHA 2XYTA 2BG9E 4ILCA 5IUXA 2WN9A 4HFCA 5JMEA 4LMLA 5HEGA 5BW2A 3TLWA 2Y58A 5KE4A 3UU6A 2BYPA 4UM3P 2YOEA 4EZ1A 2YKSA 4ILBA 4TNWA 3WTHA 3RIFA
chains in the Genus database with same CATH topology
2BG9A 2BG9B 5AFNA 1UX2A 4UM3A 2WNLA 2XZ6A 2YMDA 4HQPA 2PGZA 4NPPA 3WTMA 4ZZCA 3EHZA 3UU4A 4LMKA 2ZJUA 4TWDA 1I9BA 4B5DA 5L4HA 4XK9A 3U8JA 5AFLA 3RQUA 2BYQA 2BG9C 5SYOA 4IREA 3U8LA 3EI0A 3U8KA 5HCJA 5L4EA 3WTJA 3JAEA 4AFGA 4ZJTA 2VL0A 2XNTA 3WIPA 3TLSA 3ZKRA 3RHWA 4BQTA 3UQ7A 5CFBA 4ILAA 4QAAA 3SQ9A 4QH1A 4F8HA 5HEUA 4DBMA 4IL4A 4QH5A 4WV9A 3WTLA 5FJVA 4LMJA 4QH4A 5L47A 3C79A 4NZBA 4HFBA 3U8MA 5J5IA 2BR7A 3UU8A 3UQ4A 3EAMA 2XQ5A 2XYSA 4ZZBA 2YN6A 4XHEA 2XNUA 2BJ0A 2XQ4A 4Z90A 3WTNA 2W8FA 4PIRA 2WNJA 4HFIA 3SH1A 4HFHA 5HEOA 3SIOA 3P4WA 2YMEA 5LG3A 5KZUA 2WNCA 2XQ7A 3IGQA 2BR8A 4HFDA 2UZ6A 4UY2A 2Y54A 5BRXA 2XQAA 3TLTA 4ALXA 2W8GA 2ZJVA 5HEJA 4ZJSA 5AFMA 5AFKA 5AFMB 3LSVA 3RIAA 4UXUA 3PEOA 2X00D 2XNVA 4TWFA 5J5HA 3P50A 5BP0A 4HFEA 5J5GA 3RQWA 3UUBA 3WTKA 3JADA 4ZRUA 2BYNA 4ZK4A 4BFQA 2Y56A 5AFJA 3ZDHA 4Z91A 3UU3A 2XQ8A 2BYRA 2XZ5A 4TNVA 5HEHA 5AFHA 2X00A 4X5TA 3ZDGA 3GUAA 4A97A 2WZYA 4ZR6A 2BYSA 1UW6A 4IL9A 2Y7YA 4AFTA 3C84A 1UV6A 5AINA 3PMZA 5TVCA 5J0ZA 5HCMA 5J5FA 4UM3S 5LXBA 2QC1B 3SQ6A 4A98A 3JAFA 4QABA 2XQ9A 3WTIA 4AFHA 4FRRA 2PH9A 2C9TA 4COFA 5CO5A 3T4MA 4UM1A 3TLUA 4ZK1A 2XQ6A 3RI5A 2Y57A 4D01A 4QACA 3TLVA 3U8NA 2XQ3A 3UU5A 3WTOA 4TWHA 2XYTA 2BG9E 4ILCA 5IUXA 2WN9A 4HFCA 5JMEA 4LMLA 5HEGA 5BW2A 3TLWA 2Y58A 5KE4A 3UU6A 2BYPA 4UM3P 2YOEA 4EZ1A 2YKSA 4ILBA 4TNWA 3WTHA 3RIFA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2BG9 A;  2BG9 B;  5AFN A;  1UX2 A;  4UM3 A;  2WNL A;  2XZ6 A;  2YMD A;  4HQP A;  2PGZ A;  4NPP A;  3WTM A;  4ZZC A;  3EHZ A;  3UU4 A;  4LMK A;  2ZJU A;  4TWD A;  1I9B A;  4B5D A;  5L4H A;  4XK9 A;  3U8J A;  5AFL A;  3RQU A;  2BYQ A;  2BG9 C;  5SYO A;  4IRE A;  3U8L A;  3EI0 A;  3U8K A;  5HCJ A;  5L4E A;  3WTJ A;  3JAE A;  4AFG A;  4ZJT A;  2VL0 A;  2XNT A;  3WIP A;  3TLS A;  3ZKR A;  3RHW A;  4BQT A;  3UQ7 A;  5CFB A;  4ILA A;  4QAA A;  3SQ9 A;  4QH1 A;  4F8H A;  5HEU A;  4DBM A;  4IL4 A;  4QH5 A;  4WV9 A;  3WTL A;  5FJV A;  4LMJ A;  4QH4 A;  5L47 A;  3C79 A;  4NZB A;  4HFB A;  3U8M A;  5J5I A;  2BR7 A;  3UU8 A;  3UQ4 A;  3EAM A;  2XQ5 A;  2XYS A;  4ZZB A;  2YN6 A;  4XHE A;  2XNU A;  2BJ0 A;  2XQ4 A;  4Z90 A;  3WTN A;  2W8F A;  4PIR A;  2WNJ A;  4HFI A;  3SH1 A;  4HFH A;  5HEO A;  3SIO A;  3P4W A;  2YME A;  5LG3 A;  5KZU A;  2WNC A;  2XQ7 A;  3IGQ A;  2BR8 A;  4HFD A;  2UZ6 A;  4UY2 A;  2Y54 A;  5BRX A;  2XQA A;  3TLT A;  4ALX A;  2W8G A;  2ZJV A;  5HEJ A;  4ZJS A;  5AFM A;  5AFK A;  5AFM B;  3LSV A;  3RIA A;  4UXU A;  3PEO A;  2X00 D;  2XNV A;  4TWF A;  5J5H A;  3P50 A;  5BP0 A;  4HFE A;  5J5G A;  3RQW A;  3UUB A;  3WTK A;  3JAD A;  4ZRU A;  2BYN A;  4ZK4 A;  4BFQ A;  2Y56 A;  5AFJ A;  3ZDH A;  4Z91 A;  3UU3 A;  2XQ8 A;  2BYR A;  2XZ5 A;  4TNV A;  5HEH A;  5AFH A;  2X00 A;  4X5T A;  3ZDG A;  3GUA A;  4A97 A;  2WZY A;  4ZR6 A;  2BYS A;  1UW6 A;  4IL9 A;  2Y7Y A;  4AFT A;  3C84 A;  1UV6 A;  5AIN A;  3PMZ A;  5TVC A;  5J0Z A;  5HCM A;  5J5F A;  4UM3 S;  5LXB A;  2QC1 B;  3SQ6 A;  4A98 A;  3JAF A;  4QAB A;  2XQ9 A;  3WTI A;  4AFH A;  4FRR A;  2PH9 A;  2C9T A;  4COF A;  5CO5 A;  3T4M A;  4UM1 A;  3TLU A;  4ZK1 A;  2XQ6 A;  3RI5 A;  2Y57 A;  4D01 A;  4QAC A;  3TLV A;  3U8N A;  2XQ3 A;  3UU5 A;  3WTO A;  4TWH A;  2XYT A;  2BG9 E;  4ILC A;  5IUX A;  2WN9 A;  4HFC A;  5JME A;  4LML A;  5HEG A;  5BW2 A;  3TLW A;  2Y58 A;  5KE4 A;  3UU6 A;  2BYP A;  4UM3 P;  2YOE A;  4EZ1 A;  2YKS A;  4ILB A;  4TNW A;  3WTH A;  3RIF A; 
#chains in the Genus database with same CATH topology
 2BG9 A;  2BG9 B;  5AFN A;  1UX2 A;  4UM3 A;  2WNL A;  2XZ6 A;  2YMD A;  4HQP A;  2PGZ A;  4NPP A;  3WTM A;  4ZZC A;  3EHZ A;  3UU4 A;  4LMK A;  2ZJU A;  4TWD A;  1I9B A;  4B5D A;  5L4H A;  4XK9 A;  3U8J A;  5AFL A;  3RQU A;  2BYQ A;  2BG9 C;  5SYO A;  4IRE A;  3U8L A;  3EI0 A;  3U8K A;  5HCJ A;  5L4E A;  3WTJ A;  3JAE A;  4AFG A;  4ZJT A;  2VL0 A;  2XNT A;  3WIP A;  3TLS A;  3ZKR A;  3RHW A;  4BQT A;  3UQ7 A;  5CFB A;  4ILA A;  4QAA A;  3SQ9 A;  4QH1 A;  4F8H A;  5HEU A;  4DBM A;  4IL4 A;  4QH5 A;  4WV9 A;  3WTL A;  5FJV A;  4LMJ A;  4QH4 A;  5L47 A;  3C79 A;  4NZB A;  4HFB A;  3U8M A;  5J5I A;  2BR7 A;  3UU8 A;  3UQ4 A;  3EAM A;  2XQ5 A;  2XYS A;  4ZZB A;  2YN6 A;  4XHE A;  2XNU A;  2BJ0 A;  2XQ4 A;  4Z90 A;  3WTN A;  2W8F A;  4PIR A;  2WNJ A;  4HFI A;  3SH1 A;  4HFH A;  5HEO A;  3SIO A;  3P4W A;  2YME A;  5LG3 A;  5KZU A;  2WNC A;  2XQ7 A;  3IGQ A;  2BR8 A;  4HFD A;  2UZ6 A;  4UY2 A;  2Y54 A;  5BRX A;  2XQA A;  3TLT A;  4ALX A;  2W8G A;  2ZJV A;  5HEJ A;  4ZJS A;  5AFM A;  5AFK A;  5AFM B;  3LSV A;  3RIA A;  4UXU A;  3PEO A;  2X00 D;  2XNV A;  4TWF A;  5J5H A;  3P50 A;  5BP0 A;  4HFE A;  5J5G A;  3RQW A;  3UUB A;  3WTK A;  3JAD A;  4ZRU A;  2BYN A;  4ZK4 A;  4BFQ A;  2Y56 A;  5AFJ A;  3ZDH A;  4Z91 A;  3UU3 A;  2XQ8 A;  2BYR A;  2XZ5 A;  4TNV A;  5HEH A;  5AFH A;  2X00 A;  4X5T A;  3ZDG A;  3GUA A;  4A97 A;  2WZY A;  4ZR6 A;  2BYS A;  1UW6 A;  4IL9 A;  2Y7Y A;  4AFT A;  3C84 A;  1UV6 A;  5AIN A;  3PMZ A;  5TVC A;  5J0Z A;  5HCM A;  5J5F A;  4UM3 S;  5LXB A;  2QC1 B;  3SQ6 A;  4A98 A;  3JAF A;  4QAB A;  2XQ9 A;  3WTI A;  4AFH A;  4FRR A;  2PH9 A;  2C9T A;  4COF A;  5CO5 A;  3T4M A;  4UM1 A;  3TLU A;  4ZK1 A;  2XQ6 A;  3RI5 A;  2Y57 A;  4D01 A;  4QAC A;  3TLV A;  3U8N A;  2XQ3 A;  3UU5 A;  3WTO A;  4TWH A;  2XYT A;  2BG9 E;  4ILC A;  5IUX A;  2WN9 A;  4HFC A;  5JME A;  4LML A;  5HEG A;  5BW2 A;  3TLW A;  2Y58 A;  5KE4 A;  3UU6 A;  2BYP A;  4UM3 P;  2YOE A;  4EZ1 A;  2YKS A;  4ILB A;  4TNW A;  3WTH A;  3RIF A; 
#chains in the Genus database with same CATH homology
 2BG9 A;  2BG9 B;  5AFN A;  1UX2 A;  4UM3 A;  2WNL A;  2XZ6 A;  2YMD A;  4HQP A;  2PGZ A;  4NPP A;  3WTM A;  4ZZC A;  3EHZ A;  3UU4 A;  4LMK A;  2ZJU A;  4TWD A;  1I9B A;  4B5D A;  5L4H A;  4XK9 A;  3U8J A;  5AFL A;  3RQU A;  2BYQ A;  2BG9 C;  5SYO A;  4IRE A;  3U8L A;  3EI0 A;  3U8K A;  5HCJ A;  5L4E A;  3WTJ A;  3JAE A;  4AFG A;  4ZJT A;  2VL0 A;  2XNT A;  3WIP A;  3TLS A;  3ZKR A;  3RHW A;  4BQT A;  3UQ7 A;  5CFB A;  4ILA A;  4QAA A;  3SQ9 A;  4QH1 A;  4F8H A;  5HEU A;  4DBM A;  4IL4 A;  4QH5 A;  4WV9 A;  3WTL A;  5FJV A;  4LMJ A;  4QH4 A;  5L47 A;  3C79 A;  4NZB A;  4HFB A;  3U8M A;  5J5I A;  2BR7 A;  3UU8 A;  3UQ4 A;  3EAM A;  2XQ5 A;  2XYS A;  4ZZB A;  2YN6 A;  4XHE A;  2XNU A;  2BJ0 A;  2XQ4 A;  4Z90 A;  3WTN A;  2W8F A;  4PIR A;  2WNJ A;  4HFI A;  3SH1 A;  4HFH A;  5HEO A;  3SIO A;  3P4W A;  2YME A;  5LG3 A;  5KZU A;  2WNC A;  2XQ7 A;  3IGQ A;  2BR8 A;  4HFD A;  2UZ6 A;  4UY2 A;  2Y54 A;  5BRX A;  2XQA A;  3TLT A;  4ALX A;  2W8G A;  2ZJV A;  5HEJ A;  4ZJS A;  5AFM A;  5AFK A;  5AFM B;  3LSV A;  3RIA A;  4UXU A;  3PEO A;  2X00 D;  2XNV A;  4TWF A;  5J5H A;  3P50 A;  5BP0 A;  4HFE A;  5J5G A;  3RQW A;  3UUB A;  3WTK A;  3JAD A;  4ZRU A;  2BYN A;  4ZK4 A;  4BFQ A;  2Y56 A;  5AFJ A;  3ZDH A;  4Z91 A;  3UU3 A;  2XQ8 A;  2BYR A;  2XZ5 A;  4TNV A;  5HEH A;  5AFH A;  2X00 A;  4X5T A;  3ZDG A;  3GUA A;  4A97 A;  2WZY A;  4ZR6 A;  2BYS A;  1UW6 A;  4IL9 A;  2Y7Y A;  4AFT A;  3C84 A;  1UV6 A;  5AIN A;  3PMZ A;  5TVC A;  5J0Z A;  5HCM A;  5J5F A;  4UM3 S;  5LXB A;  2QC1 B;  3SQ6 A;  4A98 A;  3JAF A;  4QAB A;  2XQ9 A;  3WTI A;  4AFH A;  4FRR A;  2PH9 A;  2C9T A;  4COF A;  5CO5 A;  3T4M A;  4UM1 A;  3TLU A;  4ZK1 A;  2XQ6 A;  3RI5 A;  2Y57 A;  4D01 A;  4QAC A;  3TLV A;  3U8N A;  2XQ3 A;  3UU5 A;  3WTO A;  4TWH A;  2XYT A;  2BG9 E;  4ILC A;  5IUX A;  2WN9 A;  4HFC A;  5JME A;  4LML A;  5HEG A;  5BW2 A;  3TLW A;  2Y58 A;  5KE4 A;  3UU6 A;  2BYP A;  4UM3 P;  2YOE A;  4EZ1 A;  2YKS A;  4ILB A;  4TNW A;  3WTH A;  3RIF A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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