3T4MA

Ac-achbp ligand binding domain mutated to human alpha-7 nachr (intermediate)
Total Genus 49
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
49
sequence length
214
structure length
214
Chain Sequence
KDDDDKLHSQANLMRLKSDLFNRSPMYPGPTKDDPLTVTLGFTLQDIVKADSSTNEVDLVYWEQQRWKLNSLMWDPNEYGNITDFRTSAADIWTPDITAYSSTRPVQVLSPQNALVTHDGSVQYLPAQRLSFMCDPTGVDSEEGATCAVKFGSWSYSGFEIDLKTDTDQVDLSSYYASSKYEILSATQTRQVRFYECCKEPYPDVNLVVKFRER
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Receptor
source organism Aplysia californica
publication title Creating an alpha-7 nicotinic acetylcholine recognition domain from the acetylcholine binding protein: crystallographic and ligand selectivity analyses
pubmed doi rcsb
molecule keywords Soluble acetylcholine receptor
total genus 49
structure length 214
sequence length 214
chains with identical sequence B, C, D, E, F, G, H, I, J
ec nomenclature
pdb deposition date 2011-07-26

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02931 Neur_chan_LBD Neurotransmitter-gated ion-channel ligand binding domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.170.10 Mainly Beta Distorted Sandwich Acetylcholine Binding Protein; Chain: A, Neurotransmitter-gated ion-channel ligand-binding domain 3t4mA00
2BYPA 2WN9A 5HCMA 2ZJVA 4COFA 4AFHA 4AFGA 3TLUA 4IREA 4HFEA 5LG3A 2Y54A 4LMLA 5AFHA 2XQ6A 3JAEA 4PIRA 2Y57A 4QACA 2BYSA 4QH4A 3ZDGA 2Y56A 4TWFA 5BP0A 3WTMA 2W8GA 5J5HA 2WNCA 3WTIA 5KZUA 5IUXA 2X00A 4A98A 5HEOA 2C9TA 5AFJA 3P4WA 4HFBA 4EZ1A 5BW2A 2XYTA 2BG9C 4Z90A 3U8KA 5J5FA 4TWDA 4IL9A 3UUBA 4NZBA 2BR7A 2XNTA 3GUAA 3UU8A 3SIOA 3PEOA 5AFLA 3RQWA 2XYSA 4UM3P 4LMKA 4UY2A 3C84A 4TNWA 2XQAA 2BYRA 3RQUA 4UM3A 4D01A 5FJVA 3UU3A 3TLSA 2YOEA 3JAFA 2XZ5A 3U8MA 2BJ0A 2BG9B 2PH9A 2XNUA 4HFCA 2UZ6A 2XNVA 2ZJUA 4HFIA 4NPPA 4QABA 5AFMB 2XZ6A 4LMJA 3EAMA 5L47A 2BYNA 3SQ9A 3U8LA 2XQ5A 5CFBA 3EHZA 5HEUA 3JADA 4XK9A 4TWHA 4QH1A 2YKSA 3TLWA 3LSVA 3RHWA 3WTLA 4ZK4A 3WTOA 3SH1A 4XHEA 3UU4A 1I9BA 2QC1B 2XQ8A 4UXUA 4AFTA 5BRXA 2WNJA 2XQ7A 2YN6A 5HCJA 5AINA 4ZRUA 5HEJA 4HFDA 2XQ4A 3C79A 5J5GA 3PMZA 4ZR6A 5SYOA 3WTNA 3UQ4A 2WZYA 4UM1A 4QH5A 3UU6A 2X00D 4DBMA 4HFHA 4X5TA 3RIFA 4Z91A 3TLTA 4ZZBA 4FRRA 1UX2A 4ILCA 2W8FA 3SQ6A 1UV6A 5HEHA 4F8HA 4TNVA 2XQ3A 3WTHA 4A97A 3WTJA 3WIPA 4HQPA 2VL0A 5LXBA 4IL4A 3EI0A 5CO5A 1UW6A 2BR8A 4ALXA 4ILBA 3RIAA 4QAAA 4BQTA 4ZZCA 5L4EA 5J0ZA 4ZK1A 4WV9A 4UM3S 2BG9A 5AFKA 2PGZA 5J5IA 3U8JA 4BFQA 3UU5A 2XQ9A 3IGQA 5AFMA 4B5DA 2WNLA 3P50A 5TVCA 2Y7YA 3ZDHA 5L4HA 2BG9E 2Y58A 5AFNA 5JMEA 3UQ7A 2BYQA 3U8NA 2YMDA 4ZJSA 3RI5A 4ZJTA 3WTKA 4ILAA 3T4MA 3TLVA 3ZKRA 5HEGA 5KE4A 2YMEA
chains in the Genus database with same CATH superfamily
2BYPA 2WN9A 5HCMA 2ZJVA 4COFA 4AFHA 4AFGA 3TLUA 4IREA 4HFEA 5LG3A 2Y54A 4LMLA 5AFHA 2XQ6A 3JAEA 4PIRA 2Y57A 4QACA 2BYSA 4QH4A 3ZDGA 2Y56A 4TWFA 5BP0A 3WTMA 2W8GA 5J5HA 2WNCA 3WTIA 5KZUA 5IUXA 2X00A 4A98A 5HEOA 2C9TA 5AFJA 3P4WA 4HFBA 4EZ1A 5BW2A 2XYTA 2BG9C 4Z90A 3U8KA 5J5FA 4TWDA 4IL9A 3UUBA 4NZBA 2BR7A 2XNTA 3GUAA 3UU8A 3SIOA 3PEOA 5AFLA 3RQWA 2XYSA 4UM3P 4LMKA 4UY2A 3C84A 4TNWA 2XQAA 2BYRA 3RQUA 4UM3A 4D01A 5FJVA 3UU3A 3TLSA 2YOEA 3JAFA 2XZ5A 3U8MA 2BJ0A 2BG9B 2PH9A 2XNUA 4HFCA 2UZ6A 2XNVA 2ZJUA 4HFIA 4NPPA 4QABA 5AFMB 2XZ6A 4LMJA 3EAMA 5L47A 2BYNA 3SQ9A 3U8LA 2XQ5A 5CFBA 3EHZA 5HEUA 3JADA 4XK9A 4TWHA 4QH1A 2YKSA 3TLWA 3LSVA 3RHWA 3WTLA 4ZK4A 3WTOA 3SH1A 4XHEA 3UU4A 1I9BA 2QC1B 2XQ8A 4UXUA 4AFTA 5BRXA 2WNJA 2XQ7A 2YN6A 5HCJA 5AINA 4ZRUA 5HEJA 4HFDA 2XQ4A 3C79A 5J5GA 3PMZA 4ZR6A 5SYOA 3WTNA 3UQ4A 2WZYA 4UM1A 4QH5A 3UU6A 2X00D 4DBMA 4HFHA 4X5TA 3RIFA 4Z91A 3TLTA 4ZZBA 4FRRA 1UX2A 4ILCA 2W8FA 3SQ6A 1UV6A 5HEHA 4F8HA 4TNVA 2XQ3A 3WTHA 4A97A 3WTJA 3WIPA 4HQPA 2VL0A 5LXBA 4IL4A 3EI0A 5CO5A 1UW6A 2BR8A 4ALXA 4ILBA 3RIAA 4QAAA 4BQTA 4ZZCA 5L4EA 5J0ZA 4ZK1A 4WV9A 4UM3S 2BG9A 5AFKA 2PGZA 5J5IA 3U8JA 4BFQA 3UU5A 2XQ9A 3IGQA 5AFMA 4B5DA 2WNLA 3P50A 5TVCA 2Y7YA 3ZDHA 5L4HA 2BG9E 2Y58A 5AFNA 5JMEA 3UQ7A 2BYQA 3U8NA 2YMDA 4ZJSA 3RI5A 4ZJTA 3WTKA 4ILAA 3T4MA 3TLVA 3ZKRA 5HEGA 5KE4A 2YMEA
chains in the Genus database with same CATH topology
2BYPA 2WN9A 5HCMA 2ZJVA 4COFA 4AFHA 4AFGA 3TLUA 4IREA 4HFEA 5LG3A 2Y54A 4LMLA 5AFHA 2XQ6A 3JAEA 4PIRA 2Y57A 4QACA 2BYSA 4QH4A 3ZDGA 2Y56A 4TWFA 5BP0A 3WTMA 2W8GA 5J5HA 2WNCA 3WTIA 5KZUA 5IUXA 2X00A 4A98A 5HEOA 2C9TA 5AFJA 3P4WA 4HFBA 4EZ1A 5BW2A 2XYTA 2BG9C 4Z90A 3U8KA 5J5FA 4TWDA 4IL9A 3UUBA 4NZBA 2BR7A 2XNTA 3GUAA 3UU8A 3SIOA 3PEOA 5AFLA 3RQWA 2XYSA 4UM3P 4LMKA 4UY2A 3C84A 4TNWA 2XQAA 2BYRA 3RQUA 4UM3A 4D01A 5FJVA 3UU3A 3TLSA 2YOEA 3JAFA 2XZ5A 3U8MA 2BJ0A 2BG9B 2PH9A 2XNUA 4HFCA 2UZ6A 2XNVA 2ZJUA 4HFIA 4NPPA 4QABA 5AFMB 2XZ6A 4LMJA 3EAMA 5L47A 2BYNA 3SQ9A 3U8LA 2XQ5A 5CFBA 3EHZA 5HEUA 3JADA 4XK9A 4TWHA 4QH1A 2YKSA 3TLWA 3LSVA 3RHWA 3WTLA 4ZK4A 3WTOA 3SH1A 4XHEA 3UU4A 1I9BA 2QC1B 2XQ8A 4UXUA 4AFTA 5BRXA 2WNJA 2XQ7A 2YN6A 5HCJA 5AINA 4ZRUA 5HEJA 4HFDA 2XQ4A 3C79A 5J5GA 3PMZA 4ZR6A 5SYOA 3WTNA 3UQ4A 2WZYA 4UM1A 4QH5A 3UU6A 2X00D 4DBMA 4HFHA 4X5TA 3RIFA 4Z91A 3TLTA 4ZZBA 4FRRA 1UX2A 4ILCA 2W8FA 3SQ6A 1UV6A 5HEHA 4F8HA 4TNVA 2XQ3A 3WTHA 4A97A 3WTJA 3WIPA 4HQPA 2VL0A 5LXBA 4IL4A 3EI0A 5CO5A 1UW6A 2BR8A 4ALXA 4ILBA 3RIAA 4QAAA 4BQTA 4ZZCA 5L4EA 5J0ZA 4ZK1A 4WV9A 4UM3S 2BG9A 5AFKA 2PGZA 5J5IA 3U8JA 4BFQA 3UU5A 2XQ9A 3IGQA 5AFMA 4B5DA 2WNLA 3P50A 5TVCA 2Y7YA 3ZDHA 5L4HA 2BG9E 2Y58A 5AFNA 5JMEA 3UQ7A 2BYQA 3U8NA 2YMDA 4ZJSA 3RI5A 4ZJTA 3WTKA 4ILAA 3T4MA 3TLVA 3ZKRA 5HEGA 5KE4A 2YMEA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2BYP A;  2WN9 A;  5HCM A;  2ZJV A;  4COF A;  4AFH A;  4AFG A;  3TLU A;  4IRE A;  4HFE A;  5LG3 A;  2Y54 A;  4LML A;  5AFH A;  2XQ6 A;  3JAE A;  4PIR A;  2Y57 A;  4QAC A;  2BYS A;  4QH4 A;  3ZDG A;  2Y56 A;  4TWF A;  5BP0 A;  3WTM A;  2W8G A;  5J5H A;  2WNC A;  3WTI A;  5KZU A;  5IUX A;  2X00 A;  4A98 A;  5HEO A;  2C9T A;  5AFJ A;  3P4W A;  4HFB A;  4EZ1 A;  5BW2 A;  2XYT A;  2BG9 C;  4Z90 A;  3U8K A;  5J5F A;  4TWD A;  4IL9 A;  3UUB A;  4NZB A;  2BR7 A;  2XNT A;  3GUA A;  3UU8 A;  3SIO A;  3PEO A;  5AFL A;  3RQW A;  2XYS A;  4UM3 P;  4LMK A;  4UY2 A;  3C84 A;  4TNW A;  2XQA A;  2BYR A;  3RQU A;  4UM3 A;  4D01 A;  5FJV A;  3UU3 A;  3TLS A;  2YOE A;  3JAF A;  2XZ5 A;  3U8M A;  2BJ0 A;  2BG9 B;  2PH9 A;  2XNU A;  4HFC A;  2UZ6 A;  2XNV A;  2ZJU A;  4HFI A;  4NPP A;  4QAB A;  5AFM B;  2XZ6 A;  4LMJ A;  3EAM A;  5L47 A;  2BYN A;  3SQ9 A;  3U8L A;  2XQ5 A;  5CFB A;  3EHZ A;  5HEU A;  3JAD A;  4XK9 A;  4TWH A;  4QH1 A;  2YKS A;  3TLW A;  3LSV A;  3RHW A;  3WTL A;  4ZK4 A;  3WTO A;  3SH1 A;  4XHE A;  3UU4 A;  1I9B A;  2QC1 B;  2XQ8 A;  4UXU A;  4AFT A;  5BRX A;  2WNJ A;  2XQ7 A;  2YN6 A;  5HCJ A;  5AIN A;  4ZRU A;  5HEJ A;  4HFD A;  2XQ4 A;  3C79 A;  5J5G A;  3PMZ A;  4ZR6 A;  5SYO A;  3WTN A;  3UQ4 A;  2WZY A;  4UM1 A;  4QH5 A;  3UU6 A;  2X00 D;  4DBM A;  4HFH A;  4X5T A;  3RIF A;  4Z91 A;  3TLT A;  4ZZB A;  4FRR A;  1UX2 A;  4ILC A;  2W8F A;  3SQ6 A;  1UV6 A;  5HEH A;  4F8H A;  4TNV A;  2XQ3 A;  3WTH A;  4A97 A;  3WTJ A;  3WIP A;  4HQP A;  2VL0 A;  5LXB A;  4IL4 A;  3EI0 A;  5CO5 A;  1UW6 A;  2BR8 A;  4ALX A;  4ILB A;  3RIA A;  4QAA A;  4BQT A;  4ZZC A;  5L4E A;  5J0Z A;  4ZK1 A;  4WV9 A;  4UM3 S;  2BG9 A;  5AFK A;  2PGZ A;  5J5I A;  3U8J A;  4BFQ A;  3UU5 A;  2XQ9 A;  3IGQ A;  5AFM A;  4B5D A;  2WNL A;  3P50 A;  5TVC A;  2Y7Y A;  3ZDH A;  5L4H A;  2BG9 E;  2Y58 A;  5AFN A;  5JME A;  3UQ7 A;  2BYQ A;  3U8N A;  2YMD A;  4ZJS A;  3RI5 A;  4ZJT A;  3WTK A;  4ILA A;  3T4M A;  3TLV A;  3ZKR A;  5HEG A;  5KE4 A;  2YME A; 
#chains in the Genus database with same CATH topology
 2BYP A;  2WN9 A;  5HCM A;  2ZJV A;  4COF A;  4AFH A;  4AFG A;  3TLU A;  4IRE A;  4HFE A;  5LG3 A;  2Y54 A;  4LML A;  5AFH A;  2XQ6 A;  3JAE A;  4PIR A;  2Y57 A;  4QAC A;  2BYS A;  4QH4 A;  3ZDG A;  2Y56 A;  4TWF A;  5BP0 A;  3WTM A;  2W8G A;  5J5H A;  2WNC A;  3WTI A;  5KZU A;  5IUX A;  2X00 A;  4A98 A;  5HEO A;  2C9T A;  5AFJ A;  3P4W A;  4HFB A;  4EZ1 A;  5BW2 A;  2XYT A;  2BG9 C;  4Z90 A;  3U8K A;  5J5F A;  4TWD A;  4IL9 A;  3UUB A;  4NZB A;  2BR7 A;  2XNT A;  3GUA A;  3UU8 A;  3SIO A;  3PEO A;  5AFL A;  3RQW A;  2XYS A;  4UM3 P;  4LMK A;  4UY2 A;  3C84 A;  4TNW A;  2XQA A;  2BYR A;  3RQU A;  4UM3 A;  4D01 A;  5FJV A;  3UU3 A;  3TLS A;  2YOE A;  3JAF A;  2XZ5 A;  3U8M A;  2BJ0 A;  2BG9 B;  2PH9 A;  2XNU A;  4HFC A;  2UZ6 A;  2XNV A;  2ZJU A;  4HFI A;  4NPP A;  4QAB A;  5AFM B;  2XZ6 A;  4LMJ A;  3EAM A;  5L47 A;  2BYN A;  3SQ9 A;  3U8L A;  2XQ5 A;  5CFB A;  3EHZ A;  5HEU A;  3JAD A;  4XK9 A;  4TWH A;  4QH1 A;  2YKS A;  3TLW A;  3LSV A;  3RHW A;  3WTL A;  4ZK4 A;  3WTO A;  3SH1 A;  4XHE A;  3UU4 A;  1I9B A;  2QC1 B;  2XQ8 A;  4UXU A;  4AFT A;  5BRX A;  2WNJ A;  2XQ7 A;  2YN6 A;  5HCJ A;  5AIN A;  4ZRU A;  5HEJ A;  4HFD A;  2XQ4 A;  3C79 A;  5J5G A;  3PMZ A;  4ZR6 A;  5SYO A;  3WTN A;  3UQ4 A;  2WZY A;  4UM1 A;  4QH5 A;  3UU6 A;  2X00 D;  4DBM A;  4HFH A;  4X5T A;  3RIF A;  4Z91 A;  3TLT A;  4ZZB A;  4FRR A;  1UX2 A;  4ILC A;  2W8F A;  3SQ6 A;  1UV6 A;  5HEH A;  4F8H A;  4TNV A;  2XQ3 A;  3WTH A;  4A97 A;  3WTJ A;  3WIP A;  4HQP A;  2VL0 A;  5LXB A;  4IL4 A;  3EI0 A;  5CO5 A;  1UW6 A;  2BR8 A;  4ALX A;  4ILB A;  3RIA A;  4QAA A;  4BQT A;  4ZZC A;  5L4E A;  5J0Z A;  4ZK1 A;  4WV9 A;  4UM3 S;  2BG9 A;  5AFK A;  2PGZ A;  5J5I A;  3U8J A;  4BFQ A;  3UU5 A;  2XQ9 A;  3IGQ A;  5AFM A;  4B5D A;  2WNL A;  3P50 A;  5TVC A;  2Y7Y A;  3ZDH A;  5L4H A;  2BG9 E;  2Y58 A;  5AFN A;  5JME A;  3UQ7 A;  2BYQ A;  3U8N A;  2YMD A;  4ZJS A;  3RI5 A;  4ZJT A;  3WTK A;  4ILA A;  3T4M A;  3TLV A;  3ZKR A;  5HEG A;  5KE4 A;  2YME A; 
#chains in the Genus database with same CATH homology
 2BYP A;  2WN9 A;  5HCM A;  2ZJV A;  4COF A;  4AFH A;  4AFG A;  3TLU A;  4IRE A;  4HFE A;  5LG3 A;  2Y54 A;  4LML A;  5AFH A;  2XQ6 A;  3JAE A;  4PIR A;  2Y57 A;  4QAC A;  2BYS A;  4QH4 A;  3ZDG A;  2Y56 A;  4TWF A;  5BP0 A;  3WTM A;  2W8G A;  5J5H A;  2WNC A;  3WTI A;  5KZU A;  5IUX A;  2X00 A;  4A98 A;  5HEO A;  2C9T A;  5AFJ A;  3P4W A;  4HFB A;  4EZ1 A;  5BW2 A;  2XYT A;  2BG9 C;  4Z90 A;  3U8K A;  5J5F A;  4TWD A;  4IL9 A;  3UUB A;  4NZB A;  2BR7 A;  2XNT A;  3GUA A;  3UU8 A;  3SIO A;  3PEO A;  5AFL A;  3RQW A;  2XYS A;  4UM3 P;  4LMK A;  4UY2 A;  3C84 A;  4TNW A;  2XQA A;  2BYR A;  3RQU A;  4UM3 A;  4D01 A;  5FJV A;  3UU3 A;  3TLS A;  2YOE A;  3JAF A;  2XZ5 A;  3U8M A;  2BJ0 A;  2BG9 B;  2PH9 A;  2XNU A;  4HFC A;  2UZ6 A;  2XNV A;  2ZJU A;  4HFI A;  4NPP A;  4QAB A;  5AFM B;  2XZ6 A;  4LMJ A;  3EAM A;  5L47 A;  2BYN A;  3SQ9 A;  3U8L A;  2XQ5 A;  5CFB A;  3EHZ A;  5HEU A;  3JAD A;  4XK9 A;  4TWH A;  4QH1 A;  2YKS A;  3TLW A;  3LSV A;  3RHW A;  3WTL A;  4ZK4 A;  3WTO A;  3SH1 A;  4XHE A;  3UU4 A;  1I9B A;  2QC1 B;  2XQ8 A;  4UXU A;  4AFT A;  5BRX A;  2WNJ A;  2XQ7 A;  2YN6 A;  5HCJ A;  5AIN A;  4ZRU A;  5HEJ A;  4HFD A;  2XQ4 A;  3C79 A;  5J5G A;  3PMZ A;  4ZR6 A;  5SYO A;  3WTN A;  3UQ4 A;  2WZY A;  4UM1 A;  4QH5 A;  3UU6 A;  2X00 D;  4DBM A;  4HFH A;  4X5T A;  3RIF A;  4Z91 A;  3TLT A;  4ZZB A;  4FRR A;  1UX2 A;  4ILC A;  2W8F A;  3SQ6 A;  1UV6 A;  5HEH A;  4F8H A;  4TNV A;  2XQ3 A;  3WTH A;  4A97 A;  3WTJ A;  3WIP A;  4HQP A;  2VL0 A;  5LXB A;  4IL4 A;  3EI0 A;  5CO5 A;  1UW6 A;  2BR8 A;  4ALX A;  4ILB A;  3RIA A;  4QAA A;  4BQT A;  4ZZC A;  5L4E A;  5J0Z A;  4ZK1 A;  4WV9 A;  4UM3 S;  2BG9 A;  5AFK A;  2PGZ A;  5J5I A;  3U8J A;  4BFQ A;  3UU5 A;  2XQ9 A;  3IGQ A;  5AFM A;  4B5D A;  2WNL A;  3P50 A;  5TVC A;  2Y7Y A;  3ZDH A;  5L4H A;  2BG9 E;  2Y58 A;  5AFN A;  5JME A;  3UQ7 A;  2BYQ A;  3U8N A;  2YMD A;  4ZJS A;  3RI5 A;  4ZJT A;  3WTK A;  4ILA A;  3T4M A;  3TLV A;  3ZKR A;  5HEG A;  5KE4 A;  2YME A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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