4QABA

X-ray structure of acetylcholine binding protein (achbp) in complex with 4-(morpholin-4-yl)-6-[4-(trifluoromethyl)phenyl]pyrimidin-2-amine
Total Genus 43
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
43
sequence length
213
structure length
208
Chain Sequence
DYKDDDDKLDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLARVVSDGEVLYMPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural basis for cooperative interactions of substituted 2-aminopyrimidines with the acetylcholine binding protein.
pubmed doi rcsb
molecule tags Acetylcholine-binding protein
source organism Lymnaea stagnalis
molecule keywords Acetylcholine-binding protein
total genus 43
structure length 208
sequence length 213
chains with identical sequence B, C, D, E, F, G, H, I, J
ec nomenclature
pdb deposition date 2014-05-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02931 Neur_chan_LBD Neurotransmitter-gated ion-channel ligand binding domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.170.10 Mainly Beta Distorted Sandwich Acetylcholine Binding Protein; Chain: A, Neurotransmitter-gated ion-channel ligand-binding domain 4qabA00
2C9TA 2BYQA 4BQTA 3RQWA 2BYPA 4HFBA 5AFJA 3ZKRA 3TLWA 3WIPA 2X00A 3U8MA 2WZYA 5HCJA 4UM3P 3UU4A 4TNVA 3ZDHA 4QABA 5BRXA 2XQ8A 2YMDA 2WNJA 4B5DA 2BG9C 3GUAA 4ALXA 5IUXA 4TNWA 3JADA 3U8LA 5CO5A 2WNLA 4XHEA 5TVCA 4QH1A 2XZ5A 3RHWA 5KZUA 5L4HA 4LMJA 4NPPA 5HEHA 4UM3A 3TLSA 1UW6A 4HFEA 3WTKA 3WTLA 4A97A 4Z90A 5CFBA 1I9BA 3JAFA 4QACA 5AFKA 5HCMA 4LMKA 4AFGA 5J0ZA 2BYNA 4EZ1A 5AFMA 3UU5A 2XNUA 2YN6A 3P4WA 3WTOA 4AFTA 2WNCA 3SQ9A 4QH4A 3TLTA 2ZJVA 2YMEA 1UX2A 2XQ4A 3UU6A 5AFHA 5KE4A 4HQPA 4TWHA 2Y57A 4QAAA 4NZBA 4TWDA 3WTIA 4ILBA 2Y7YA 5LG3A 2XNTA 4AFHA 1UV6A 3EI0A 3JAEA 4ZZCA 2XQ7A 3RIAA 4FRRA 2BG9B 4PIRA 3P50A 2YOEA 3IGQA 5BW2A 2PH9A 4UXUA 5J5IA 3TLUA 2W8FA 4IL4A 2QC1B 3LSVA 3U8KA 5HEUA 2XQ9A 3EAMA 4ZR6A 4LMLA 3SH1A 5J5HA 4BFQA 5AFNA 2YKSA 3UQ4A 3EHZA 2WN9A 4XK9A 2XNVA 4ZRUA 3RI5A 3UUBA 2UZ6A 4ILCA 2Y58A 3SIOA 3UU8A 5FJVA 3SQ6A 4A98A 5AFMB 5JMEA 2ZJUA 5J5GA 4TWFA 3WTJA 5L4EA 4IL9A 4ZJSA 2PGZA 3U8NA 4UY2A 3UU3A 4DBMA 2VL0A 3RIFA 4F8HA 5J5FA 3PMZA 2BJ0A 5AINA 2BR8A 4HFDA 3TLVA 3C84A 4Z91A 3U8JA 5L47A 2XQ5A 4QH5A 5HEOA 5SYOA 2XYTA 4ZJTA 3PEOA 4UM1A 2BR7A 4HFCA 4ZK4A 2XYSA 2BG9A 4HFIA 2XQ6A 3WTHA 5BP0A 2BG9E 5HEJA 4X5TA 3C79A 4COFA 2Y56A 3UQ7A 3ZDGA 4UM3S 2BYRA 4IREA 3WTMA 3T4MA 2XQ3A 2Y54A 4ZK1A 5AFLA 4HFHA 2X00D 5HEGA 4ZZBA 4D01A 4ILAA 2XQAA 3RQUA 3WTNA 5LXBA 2BYSA 4WV9A 2W8GA 2XZ6A
chains in the Genus database with same CATH superfamily
2C9TA 2BYQA 4BQTA 3RQWA 2BYPA 4HFBA 5AFJA 3ZKRA 3TLWA 3WIPA 2X00A 3U8MA 2WZYA 5HCJA 4UM3P 3UU4A 4TNVA 3ZDHA 4QABA 5BRXA 2XQ8A 2YMDA 2WNJA 4B5DA 2BG9C 3GUAA 4ALXA 5IUXA 4TNWA 3JADA 3U8LA 5CO5A 2WNLA 4XHEA 5TVCA 4QH1A 2XZ5A 3RHWA 5KZUA 5L4HA 4LMJA 4NPPA 5HEHA 4UM3A 3TLSA 1UW6A 4HFEA 3WTKA 3WTLA 4A97A 4Z90A 5CFBA 1I9BA 3JAFA 4QACA 5AFKA 5HCMA 4LMKA 4AFGA 5J0ZA 2BYNA 4EZ1A 5AFMA 3UU5A 2XNUA 2YN6A 3P4WA 3WTOA 4AFTA 2WNCA 3SQ9A 4QH4A 3TLTA 2ZJVA 2YMEA 1UX2A 2XQ4A 3UU6A 5AFHA 5KE4A 4HQPA 4TWHA 2Y57A 4QAAA 4NZBA 4TWDA 3WTIA 4ILBA 2Y7YA 5LG3A 2XNTA 4AFHA 1UV6A 3EI0A 3JAEA 4ZZCA 2XQ7A 3RIAA 4FRRA 2BG9B 4PIRA 3P50A 2YOEA 3IGQA 5BW2A 2PH9A 4UXUA 5J5IA 3TLUA 2W8FA 4IL4A 2QC1B 3LSVA 3U8KA 5HEUA 2XQ9A 3EAMA 4ZR6A 4LMLA 3SH1A 5J5HA 4BFQA 5AFNA 2YKSA 3UQ4A 3EHZA 2WN9A 4XK9A 2XNVA 4ZRUA 3RI5A 3UUBA 2UZ6A 4ILCA 2Y58A 3SIOA 3UU8A 5FJVA 3SQ6A 4A98A 5AFMB 5JMEA 2ZJUA 5J5GA 4TWFA 3WTJA 5L4EA 4IL9A 4ZJSA 2PGZA 3U8NA 4UY2A 3UU3A 4DBMA 2VL0A 3RIFA 4F8HA 5J5FA 3PMZA 2BJ0A 5AINA 2BR8A 4HFDA 3TLVA 3C84A 4Z91A 3U8JA 5L47A 2XQ5A 4QH5A 5HEOA 5SYOA 2XYTA 4ZJTA 3PEOA 4UM1A 2BR7A 4HFCA 4ZK4A 2XYSA 2BG9A 4HFIA 2XQ6A 3WTHA 5BP0A 2BG9E 5HEJA 4X5TA 3C79A 4COFA 2Y56A 3UQ7A 3ZDGA 4UM3S 2BYRA 4IREA 3WTMA 3T4MA 2XQ3A 2Y54A 4ZK1A 5AFLA 4HFHA 2X00D 5HEGA 4ZZBA 4D01A 4ILAA 2XQAA 3RQUA 3WTNA 5LXBA 2BYSA 4WV9A 2W8GA 2XZ6A
chains in the Genus database with same CATH topology
2C9TA 2BYQA 4BQTA 3RQWA 2BYPA 4HFBA 5AFJA 3ZKRA 3TLWA 3WIPA 2X00A 3U8MA 2WZYA 5HCJA 4UM3P 3UU4A 4TNVA 3ZDHA 4QABA 5BRXA 2XQ8A 2YMDA 2WNJA 4B5DA 2BG9C 3GUAA 4ALXA 5IUXA 4TNWA 3JADA 3U8LA 5CO5A 2WNLA 4XHEA 5TVCA 4QH1A 2XZ5A 3RHWA 5KZUA 5L4HA 4LMJA 4NPPA 5HEHA 4UM3A 3TLSA 1UW6A 4HFEA 3WTKA 3WTLA 4A97A 4Z90A 5CFBA 1I9BA 3JAFA 4QACA 5AFKA 5HCMA 4LMKA 4AFGA 5J0ZA 2BYNA 4EZ1A 5AFMA 3UU5A 2XNUA 2YN6A 3P4WA 3WTOA 4AFTA 2WNCA 3SQ9A 4QH4A 3TLTA 2ZJVA 2YMEA 1UX2A 2XQ4A 3UU6A 5AFHA 5KE4A 4HQPA 4TWHA 2Y57A 4QAAA 4NZBA 4TWDA 3WTIA 4ILBA 2Y7YA 5LG3A 2XNTA 4AFHA 1UV6A 3EI0A 3JAEA 4ZZCA 2XQ7A 3RIAA 4FRRA 2BG9B 4PIRA 3P50A 2YOEA 3IGQA 5BW2A 2PH9A 4UXUA 5J5IA 3TLUA 2W8FA 4IL4A 2QC1B 3LSVA 3U8KA 5HEUA 2XQ9A 3EAMA 4ZR6A 4LMLA 3SH1A 5J5HA 4BFQA 5AFNA 2YKSA 3UQ4A 3EHZA 2WN9A 4XK9A 2XNVA 4ZRUA 3RI5A 3UUBA 2UZ6A 4ILCA 2Y58A 3SIOA 3UU8A 5FJVA 3SQ6A 4A98A 5AFMB 5JMEA 2ZJUA 5J5GA 4TWFA 3WTJA 5L4EA 4IL9A 4ZJSA 2PGZA 3U8NA 4UY2A 3UU3A 4DBMA 2VL0A 3RIFA 4F8HA 5J5FA 3PMZA 2BJ0A 5AINA 2BR8A 4HFDA 3TLVA 3C84A 4Z91A 3U8JA 5L47A 2XQ5A 4QH5A 5HEOA 5SYOA 2XYTA 4ZJTA 3PEOA 4UM1A 2BR7A 4HFCA 4ZK4A 2XYSA 2BG9A 4HFIA 2XQ6A 3WTHA 5BP0A 2BG9E 5HEJA 4X5TA 3C79A 4COFA 2Y56A 3UQ7A 3ZDGA 4UM3S 2BYRA 4IREA 3WTMA 3T4MA 2XQ3A 2Y54A 4ZK1A 5AFLA 4HFHA 2X00D 5HEGA 4ZZBA 4D01A 4ILAA 2XQAA 3RQUA 3WTNA 5LXBA 2BYSA 4WV9A 2W8GA 2XZ6A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2C9T A;  2BYQ A;  4BQT A;  3RQW A;  2BYP A;  4HFB A;  5AFJ A;  3ZKR A;  3TLW A;  3WIP A;  2X00 A;  3U8M A;  2WZY A;  5HCJ A;  4UM3 P;  3UU4 A;  4TNV A;  3ZDH A;  4QAB A;  5BRX A;  2XQ8 A;  2YMD A;  2WNJ A;  4B5D A;  2BG9 C;  3GUA A;  4ALX A;  5IUX A;  4TNW A;  3JAD A;  3U8L A;  5CO5 A;  2WNL A;  4XHE A;  5TVC A;  4QH1 A;  2XZ5 A;  3RHW A;  5KZU A;  5L4H A;  4LMJ A;  4NPP A;  5HEH A;  4UM3 A;  3TLS A;  1UW6 A;  4HFE A;  3WTK A;  3WTL A;  4A97 A;  4Z90 A;  5CFB A;  1I9B A;  3JAF A;  4QAC A;  5AFK A;  5HCM A;  4LMK A;  4AFG A;  5J0Z A;  2BYN A;  4EZ1 A;  5AFM A;  3UU5 A;  2XNU A;  2YN6 A;  3P4W A;  3WTO A;  4AFT A;  2WNC A;  3SQ9 A;  4QH4 A;  3TLT A;  2ZJV A;  2YME A;  1UX2 A;  2XQ4 A;  3UU6 A;  5AFH A;  5KE4 A;  4HQP A;  4TWH A;  2Y57 A;  4QAA A;  4NZB A;  4TWD A;  3WTI A;  4ILB A;  2Y7Y A;  5LG3 A;  2XNT A;  4AFH A;  1UV6 A;  3EI0 A;  3JAE A;  4ZZC A;  2XQ7 A;  3RIA A;  4FRR A;  2BG9 B;  4PIR A;  3P50 A;  2YOE A;  3IGQ A;  5BW2 A;  2PH9 A;  4UXU A;  5J5I A;  3TLU A;  2W8F A;  4IL4 A;  2QC1 B;  3LSV A;  3U8K A;  5HEU A;  2XQ9 A;  3EAM A;  4ZR6 A;  4LML A;  3SH1 A;  5J5H A;  4BFQ A;  5AFN A;  2YKS A;  3UQ4 A;  3EHZ A;  2WN9 A;  4XK9 A;  2XNV A;  4ZRU A;  3RI5 A;  3UUB A;  2UZ6 A;  4ILC A;  2Y58 A;  3SIO A;  3UU8 A;  5FJV A;  3SQ6 A;  4A98 A;  5AFM B;  5JME A;  2ZJU A;  5J5G A;  4TWF A;  3WTJ A;  5L4E A;  4IL9 A;  4ZJS A;  2PGZ A;  3U8N A;  4UY2 A;  3UU3 A;  4DBM A;  2VL0 A;  3RIF A;  4F8H A;  5J5F A;  3PMZ A;  2BJ0 A;  5AIN A;  2BR8 A;  4HFD A;  3TLV A;  3C84 A;  4Z91 A;  3U8J A;  5L47 A;  2XQ5 A;  4QH5 A;  5HEO A;  5SYO A;  2XYT A;  4ZJT A;  3PEO A;  4UM1 A;  2BR7 A;  4HFC A;  4ZK4 A;  2XYS A;  2BG9 A;  4HFI A;  2XQ6 A;  3WTH A;  5BP0 A;  2BG9 E;  5HEJ A;  4X5T A;  3C79 A;  4COF A;  2Y56 A;  3UQ7 A;  3ZDG A;  4UM3 S;  2BYR A;  4IRE A;  3WTM A;  3T4M A;  2XQ3 A;  2Y54 A;  4ZK1 A;  5AFL A;  4HFH A;  2X00 D;  5HEG A;  4ZZB A;  4D01 A;  4ILA A;  2XQA A;  3RQU A;  3WTN A;  5LXB A;  2BYS A;  4WV9 A;  2W8G A;  2XZ6 A; 
#chains in the Genus database with same CATH topology
 2C9T A;  2BYQ A;  4BQT A;  3RQW A;  2BYP A;  4HFB A;  5AFJ A;  3ZKR A;  3TLW A;  3WIP A;  2X00 A;  3U8M A;  2WZY A;  5HCJ A;  4UM3 P;  3UU4 A;  4TNV A;  3ZDH A;  4QAB A;  5BRX A;  2XQ8 A;  2YMD A;  2WNJ A;  4B5D A;  2BG9 C;  3GUA A;  4ALX A;  5IUX A;  4TNW A;  3JAD A;  3U8L A;  5CO5 A;  2WNL A;  4XHE A;  5TVC A;  4QH1 A;  2XZ5 A;  3RHW A;  5KZU A;  5L4H A;  4LMJ A;  4NPP A;  5HEH A;  4UM3 A;  3TLS A;  1UW6 A;  4HFE A;  3WTK A;  3WTL A;  4A97 A;  4Z90 A;  5CFB A;  1I9B A;  3JAF A;  4QAC A;  5AFK A;  5HCM A;  4LMK A;  4AFG A;  5J0Z A;  2BYN A;  4EZ1 A;  5AFM A;  3UU5 A;  2XNU A;  2YN6 A;  3P4W A;  3WTO A;  4AFT A;  2WNC A;  3SQ9 A;  4QH4 A;  3TLT A;  2ZJV A;  2YME A;  1UX2 A;  2XQ4 A;  3UU6 A;  5AFH A;  5KE4 A;  4HQP A;  4TWH A;  2Y57 A;  4QAA A;  4NZB A;  4TWD A;  3WTI A;  4ILB A;  2Y7Y A;  5LG3 A;  2XNT A;  4AFH A;  1UV6 A;  3EI0 A;  3JAE A;  4ZZC A;  2XQ7 A;  3RIA A;  4FRR A;  2BG9 B;  4PIR A;  3P50 A;  2YOE A;  3IGQ A;  5BW2 A;  2PH9 A;  4UXU A;  5J5I A;  3TLU A;  2W8F A;  4IL4 A;  2QC1 B;  3LSV A;  3U8K A;  5HEU A;  2XQ9 A;  3EAM A;  4ZR6 A;  4LML A;  3SH1 A;  5J5H A;  4BFQ A;  5AFN A;  2YKS A;  3UQ4 A;  3EHZ A;  2WN9 A;  4XK9 A;  2XNV A;  4ZRU A;  3RI5 A;  3UUB A;  2UZ6 A;  4ILC A;  2Y58 A;  3SIO A;  3UU8 A;  5FJV A;  3SQ6 A;  4A98 A;  5AFM B;  5JME A;  2ZJU A;  5J5G A;  4TWF A;  3WTJ A;  5L4E A;  4IL9 A;  4ZJS A;  2PGZ A;  3U8N A;  4UY2 A;  3UU3 A;  4DBM A;  2VL0 A;  3RIF A;  4F8H A;  5J5F A;  3PMZ A;  2BJ0 A;  5AIN A;  2BR8 A;  4HFD A;  3TLV A;  3C84 A;  4Z91 A;  3U8J A;  5L47 A;  2XQ5 A;  4QH5 A;  5HEO A;  5SYO A;  2XYT A;  4ZJT A;  3PEO A;  4UM1 A;  2BR7 A;  4HFC A;  4ZK4 A;  2XYS A;  2BG9 A;  4HFI A;  2XQ6 A;  3WTH A;  5BP0 A;  2BG9 E;  5HEJ A;  4X5T A;  3C79 A;  4COF A;  2Y56 A;  3UQ7 A;  3ZDG A;  4UM3 S;  2BYR A;  4IRE A;  3WTM A;  3T4M A;  2XQ3 A;  2Y54 A;  4ZK1 A;  5AFL A;  4HFH A;  2X00 D;  5HEG A;  4ZZB A;  4D01 A;  4ILA A;  2XQA A;  3RQU A;  3WTN A;  5LXB A;  2BYS A;  4WV9 A;  2W8G A;  2XZ6 A; 
#chains in the Genus database with same CATH homology
 2C9T A;  2BYQ A;  4BQT A;  3RQW A;  2BYP A;  4HFB A;  5AFJ A;  3ZKR A;  3TLW A;  3WIP A;  2X00 A;  3U8M A;  2WZY A;  5HCJ A;  4UM3 P;  3UU4 A;  4TNV A;  3ZDH A;  4QAB A;  5BRX A;  2XQ8 A;  2YMD A;  2WNJ A;  4B5D A;  2BG9 C;  3GUA A;  4ALX A;  5IUX A;  4TNW A;  3JAD A;  3U8L A;  5CO5 A;  2WNL A;  4XHE A;  5TVC A;  4QH1 A;  2XZ5 A;  3RHW A;  5KZU A;  5L4H A;  4LMJ A;  4NPP A;  5HEH A;  4UM3 A;  3TLS A;  1UW6 A;  4HFE A;  3WTK A;  3WTL A;  4A97 A;  4Z90 A;  5CFB A;  1I9B A;  3JAF A;  4QAC A;  5AFK A;  5HCM A;  4LMK A;  4AFG A;  5J0Z A;  2BYN A;  4EZ1 A;  5AFM A;  3UU5 A;  2XNU A;  2YN6 A;  3P4W A;  3WTO A;  4AFT A;  2WNC A;  3SQ9 A;  4QH4 A;  3TLT A;  2ZJV A;  2YME A;  1UX2 A;  2XQ4 A;  3UU6 A;  5AFH A;  5KE4 A;  4HQP A;  4TWH A;  2Y57 A;  4QAA A;  4NZB A;  4TWD A;  3WTI A;  4ILB A;  2Y7Y A;  5LG3 A;  2XNT A;  4AFH A;  1UV6 A;  3EI0 A;  3JAE A;  4ZZC A;  2XQ7 A;  3RIA A;  4FRR A;  2BG9 B;  4PIR A;  3P50 A;  2YOE A;  3IGQ A;  5BW2 A;  2PH9 A;  4UXU A;  5J5I A;  3TLU A;  2W8F A;  4IL4 A;  2QC1 B;  3LSV A;  3U8K A;  5HEU A;  2XQ9 A;  3EAM A;  4ZR6 A;  4LML A;  3SH1 A;  5J5H A;  4BFQ A;  5AFN A;  2YKS A;  3UQ4 A;  3EHZ A;  2WN9 A;  4XK9 A;  2XNV A;  4ZRU A;  3RI5 A;  3UUB A;  2UZ6 A;  4ILC A;  2Y58 A;  3SIO A;  3UU8 A;  5FJV A;  3SQ6 A;  4A98 A;  5AFM B;  5JME A;  2ZJU A;  5J5G A;  4TWF A;  3WTJ A;  5L4E A;  4IL9 A;  4ZJS A;  2PGZ A;  3U8N A;  4UY2 A;  3UU3 A;  4DBM A;  2VL0 A;  3RIF A;  4F8H A;  5J5F A;  3PMZ A;  2BJ0 A;  5AIN A;  2BR8 A;  4HFD A;  3TLV A;  3C84 A;  4Z91 A;  3U8J A;  5L47 A;  2XQ5 A;  4QH5 A;  5HEO A;  5SYO A;  2XYT A;  4ZJT A;  3PEO A;  4UM1 A;  2BR7 A;  4HFC A;  4ZK4 A;  2XYS A;  2BG9 A;  4HFI A;  2XQ6 A;  3WTH A;  5BP0 A;  2BG9 E;  5HEJ A;  4X5T A;  3C79 A;  4COF A;  2Y56 A;  3UQ7 A;  3ZDG A;  4UM3 S;  2BYR A;  4IRE A;  3WTM A;  3T4M A;  2XQ3 A;  2Y54 A;  4ZK1 A;  5AFL A;  4HFH A;  2X00 D;  5HEG A;  4ZZB A;  4D01 A;  4ILA A;  2XQA A;  3RQU A;  3WTN A;  5LXB A;  2BYS A;  4WV9 A;  2W8G A;  2XZ6 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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