4QACA

X-ray structure of acetylcholine binding protein (achbp) in complex with 4-(4-methylpiperidin-1-yl)-6-(4-(trifluoromethyl)phenyl)pyrimidin-2-amine
Total Genus 52
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
52
sequence length
213
structure length
209
Chain Sequence
DYKDDDDKLDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLARVVSDGEVLYMPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTDDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural basis for cooperative interactions of substituted 2-aminopyrimidines with the acetylcholine binding protein.
pubmed doi rcsb
molecule tags Acetylcholine-binding protein
source organism Lymnaea stagnalis
molecule keywords Acetylcholine-binding protein
total genus 52
structure length 209
sequence length 213
chains with identical sequence B, C, D, E, F, G, H, I, J
ec nomenclature
pdb deposition date 2014-05-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02931 Neur_chan_LBD Neurotransmitter-gated ion-channel ligand binding domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.170.10 Mainly Beta Distorted Sandwich Acetylcholine Binding Protein; Chain: A, Neurotransmitter-gated ion-channel ligand-binding domain 4qacA00
5BRXA 5J5GA 4TWFA 5KZUA 5AFMB 3UU4A 5CFBA 2WZYA 2XYSA 2YKSA 3TLSA 2X00A 2C9TA 2PGZA 5J5FA 2XQ7A 5SYOA 2XNUA 2Y57A 4XHEA 3WTIA 4COFA 3P50A 2YMEA 4IL4A 4XK9A 3UU3A 4HQPA 4NPPA 4QH5A 5AINA 5AFMA 2UZ6A 4AFTA 4F8HA 4AFHA 5AFHA 3WTOA 2Y7YA 5J5IA 4QH1A 3SQ6A 4QABA 4ZR6A 2BYPA 4QH4A 4TWHA 5L47A 4BFQA 5BW2A 4TNVA 5IUXA 2BJ0A 2ZJVA 3UUBA 5HEGA 3RIAA 3U8LA 4UM3S 4FRRA 3WTMA 2BYRA 3ZKRA 4HFCA 4QACA 3JADA 3EHZA 3RQWA 2XQ3A 5AFJA 3UU6A 5LXBA 2BR7A 2YMDA 3TLWA 4D01A 4LMJA 4IL9A 4HFBA 3RHWA 2XNVA 2XQ8A 3P4WA 5HEUA 1UW6A 1UX2A 2XQAA 3UU5A 5TVCA 4X5TA 5L4EA 4WV9A 3C84A 3PMZA 4LMKA 4HFHA 3RI5A 5KE4A 4ALXA 2W8GA 3EAMA 2BYNA 3UU8A 4LMLA 5AFLA 4Z90A 3TLUA 3C79A 5HCJA 3SH1A 3RIFA 5J0ZA 5AFKA 5HEJA 4UM3P 4ZZCA 3WTHA 2XQ4A 5HEHA 1UV6A 2BG9B 5FJVA 2XYTA 4UM3A 3WTJA 3U8NA 2YN6A 3T4MA 3GUAA 3WTNA 3RQUA 3SIOA 2ZJUA 3TLTA 3ZDGA 4ZZBA 2WN9A 2WNLA 4UM1A 3JAEA 5JMEA 2BG9A 4UY2A 5LG3A 2BYSA 2PH9A 2BG9C 2XZ6A 2Y56A 3WIPA 2WNJA 3LSVA 2XQ5A 4HFDA 3TLVA 2YOEA 3UQ7A 4IREA 3JAFA 3SQ9A 4PIRA 2QC1B 5BP0A 4EZ1A 4TNWA 2BR8A 4HFEA 4ILCA 4DBMA 4A97A 2XQ9A 2XQ6A 4ZJTA 4ILAA 5HCMA 4AFGA 2Y54A 3U8MA 4Z91A 3PEOA 4TWDA 5AFNA 4ZRUA 4ZK1A 4HFIA 4NZBA 2Y58A 4A98A 4QAAA 2XNTA 3WTLA 2VL0A 2WNCA 3U8JA 4ILBA 5J5HA 5HEOA 2W8FA 5L4HA 1I9BA 2BG9E 5CO5A 4B5DA 3IGQA 3WTKA 4ZJSA 2X00D 2XZ5A 3U8KA 4BQTA 3UQ4A 4UXUA 2BYQA 3EI0A 4ZK4A 3ZDHA
chains in the Genus database with same CATH superfamily
5BRXA 5J5GA 4TWFA 5KZUA 5AFMB 3UU4A 5CFBA 2WZYA 2XYSA 2YKSA 3TLSA 2X00A 2C9TA 2PGZA 5J5FA 2XQ7A 5SYOA 2XNUA 2Y57A 4XHEA 3WTIA 4COFA 3P50A 2YMEA 4IL4A 4XK9A 3UU3A 4HQPA 4NPPA 4QH5A 5AINA 5AFMA 2UZ6A 4AFTA 4F8HA 4AFHA 5AFHA 3WTOA 2Y7YA 5J5IA 4QH1A 3SQ6A 4QABA 4ZR6A 2BYPA 4QH4A 4TWHA 5L47A 4BFQA 5BW2A 4TNVA 5IUXA 2BJ0A 2ZJVA 3UUBA 5HEGA 3RIAA 3U8LA 4UM3S 4FRRA 3WTMA 2BYRA 3ZKRA 4HFCA 4QACA 3JADA 3EHZA 3RQWA 2XQ3A 5AFJA 3UU6A 5LXBA 2BR7A 2YMDA 3TLWA 4D01A 4LMJA 4IL9A 4HFBA 3RHWA 2XNVA 2XQ8A 3P4WA 5HEUA 1UW6A 1UX2A 2XQAA 3UU5A 5TVCA 4X5TA 5L4EA 4WV9A 3C84A 3PMZA 4LMKA 4HFHA 3RI5A 5KE4A 4ALXA 2W8GA 3EAMA 2BYNA 3UU8A 4LMLA 5AFLA 4Z90A 3TLUA 3C79A 5HCJA 3SH1A 3RIFA 5J0ZA 5AFKA 5HEJA 4UM3P 4ZZCA 3WTHA 2XQ4A 5HEHA 1UV6A 2BG9B 5FJVA 2XYTA 4UM3A 3WTJA 3U8NA 2YN6A 3T4MA 3GUAA 3WTNA 3RQUA 3SIOA 2ZJUA 3TLTA 3ZDGA 4ZZBA 2WN9A 2WNLA 4UM1A 3JAEA 5JMEA 2BG9A 4UY2A 5LG3A 2BYSA 2PH9A 2BG9C 2XZ6A 2Y56A 3WIPA 2WNJA 3LSVA 2XQ5A 4HFDA 3TLVA 2YOEA 3UQ7A 4IREA 3JAFA 3SQ9A 4PIRA 2QC1B 5BP0A 4EZ1A 4TNWA 2BR8A 4HFEA 4ILCA 4DBMA 4A97A 2XQ9A 2XQ6A 4ZJTA 4ILAA 5HCMA 4AFGA 2Y54A 3U8MA 4Z91A 3PEOA 4TWDA 5AFNA 4ZRUA 4ZK1A 4HFIA 4NZBA 2Y58A 4A98A 4QAAA 2XNTA 3WTLA 2VL0A 2WNCA 3U8JA 4ILBA 5J5HA 5HEOA 2W8FA 5L4HA 1I9BA 2BG9E 5CO5A 4B5DA 3IGQA 3WTKA 4ZJSA 2X00D 2XZ5A 3U8KA 4BQTA 3UQ4A 4UXUA 2BYQA 3EI0A 4ZK4A 3ZDHA
chains in the Genus database with same CATH topology
5BRXA 5J5GA 4TWFA 5KZUA 5AFMB 3UU4A 5CFBA 2WZYA 2XYSA 2YKSA 3TLSA 2X00A 2C9TA 2PGZA 5J5FA 2XQ7A 5SYOA 2XNUA 2Y57A 4XHEA 3WTIA 4COFA 3P50A 2YMEA 4IL4A 4XK9A 3UU3A 4HQPA 4NPPA 4QH5A 5AINA 5AFMA 2UZ6A 4AFTA 4F8HA 4AFHA 5AFHA 3WTOA 2Y7YA 5J5IA 4QH1A 3SQ6A 4QABA 4ZR6A 2BYPA 4QH4A 4TWHA 5L47A 4BFQA 5BW2A 4TNVA 5IUXA 2BJ0A 2ZJVA 3UUBA 5HEGA 3RIAA 3U8LA 4UM3S 4FRRA 3WTMA 2BYRA 3ZKRA 4HFCA 4QACA 3JADA 3EHZA 3RQWA 2XQ3A 5AFJA 3UU6A 5LXBA 2BR7A 2YMDA 3TLWA 4D01A 4LMJA 4IL9A 4HFBA 3RHWA 2XNVA 2XQ8A 3P4WA 5HEUA 1UW6A 1UX2A 2XQAA 3UU5A 5TVCA 4X5TA 5L4EA 4WV9A 3C84A 3PMZA 4LMKA 4HFHA 3RI5A 5KE4A 4ALXA 2W8GA 3EAMA 2BYNA 3UU8A 4LMLA 5AFLA 4Z90A 3TLUA 3C79A 5HCJA 3SH1A 3RIFA 5J0ZA 5AFKA 5HEJA 4UM3P 4ZZCA 3WTHA 2XQ4A 5HEHA 1UV6A 2BG9B 5FJVA 2XYTA 4UM3A 3WTJA 3U8NA 2YN6A 3T4MA 3GUAA 3WTNA 3RQUA 3SIOA 2ZJUA 3TLTA 3ZDGA 4ZZBA 2WN9A 2WNLA 4UM1A 3JAEA 5JMEA 2BG9A 4UY2A 5LG3A 2BYSA 2PH9A 2BG9C 2XZ6A 2Y56A 3WIPA 2WNJA 3LSVA 2XQ5A 4HFDA 3TLVA 2YOEA 3UQ7A 4IREA 3JAFA 3SQ9A 4PIRA 2QC1B 5BP0A 4EZ1A 4TNWA 2BR8A 4HFEA 4ILCA 4DBMA 4A97A 2XQ9A 2XQ6A 4ZJTA 4ILAA 5HCMA 4AFGA 2Y54A 3U8MA 4Z91A 3PEOA 4TWDA 5AFNA 4ZRUA 4ZK1A 4HFIA 4NZBA 2Y58A 4A98A 4QAAA 2XNTA 3WTLA 2VL0A 2WNCA 3U8JA 4ILBA 5J5HA 5HEOA 2W8FA 5L4HA 1I9BA 2BG9E 5CO5A 4B5DA 3IGQA 3WTKA 4ZJSA 2X00D 2XZ5A 3U8KA 4BQTA 3UQ4A 4UXUA 2BYQA 3EI0A 4ZK4A 3ZDHA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5BRX A;  5J5G A;  4TWF A;  5KZU A;  5AFM B;  3UU4 A;  5CFB A;  2WZY A;  2XYS A;  2YKS A;  3TLS A;  2X00 A;  2C9T A;  2PGZ A;  5J5F A;  2XQ7 A;  5SYO A;  2XNU A;  2Y57 A;  4XHE A;  3WTI A;  4COF A;  3P50 A;  2YME A;  4IL4 A;  4XK9 A;  3UU3 A;  4HQP A;  4NPP A;  4QH5 A;  5AIN A;  5AFM A;  2UZ6 A;  4AFT A;  4F8H A;  4AFH A;  5AFH A;  3WTO A;  2Y7Y A;  5J5I A;  4QH1 A;  3SQ6 A;  4QAB A;  4ZR6 A;  2BYP A;  4QH4 A;  4TWH A;  5L47 A;  4BFQ A;  5BW2 A;  4TNV A;  5IUX A;  2BJ0 A;  2ZJV A;  3UUB A;  5HEG A;  3RIA A;  3U8L A;  4UM3 S;  4FRR A;  3WTM A;  2BYR A;  3ZKR A;  4HFC A;  4QAC A;  3JAD A;  3EHZ A;  3RQW A;  2XQ3 A;  5AFJ A;  3UU6 A;  5LXB A;  2BR7 A;  2YMD A;  3TLW A;  4D01 A;  4LMJ A;  4IL9 A;  4HFB A;  3RHW A;  2XNV A;  2XQ8 A;  3P4W A;  5HEU A;  1UW6 A;  1UX2 A;  2XQA A;  3UU5 A;  5TVC A;  4X5T A;  5L4E A;  4WV9 A;  3C84 A;  3PMZ A;  4LMK A;  4HFH A;  3RI5 A;  5KE4 A;  4ALX A;  2W8G A;  3EAM A;  2BYN A;  3UU8 A;  4LML A;  5AFL A;  4Z90 A;  3TLU A;  3C79 A;  5HCJ A;  3SH1 A;  3RIF A;  5J0Z A;  5AFK A;  5HEJ A;  4UM3 P;  4ZZC A;  3WTH A;  2XQ4 A;  5HEH A;  1UV6 A;  2BG9 B;  5FJV A;  2XYT A;  4UM3 A;  3WTJ A;  3U8N A;  2YN6 A;  3T4M A;  3GUA A;  3WTN A;  3RQU A;  3SIO A;  2ZJU A;  3TLT A;  3ZDG A;  4ZZB A;  2WN9 A;  2WNL A;  4UM1 A;  3JAE A;  5JME A;  2BG9 A;  4UY2 A;  5LG3 A;  2BYS A;  2PH9 A;  2BG9 C;  2XZ6 A;  2Y56 A;  3WIP A;  2WNJ A;  3LSV A;  2XQ5 A;  4HFD A;  3TLV A;  2YOE A;  3UQ7 A;  4IRE A;  3JAF A;  3SQ9 A;  4PIR A;  2QC1 B;  5BP0 A;  4EZ1 A;  4TNW A;  2BR8 A;  4HFE A;  4ILC A;  4DBM A;  4A97 A;  2XQ9 A;  2XQ6 A;  4ZJT A;  4ILA A;  5HCM A;  4AFG A;  2Y54 A;  3U8M A;  4Z91 A;  3PEO A;  4TWD A;  5AFN A;  4ZRU A;  4ZK1 A;  4HFI A;  4NZB A;  2Y58 A;  4A98 A;  4QAA A;  2XNT A;  3WTL A;  2VL0 A;  2WNC A;  3U8J A;  4ILB A;  5J5H A;  5HEO A;  2W8F A;  5L4H A;  1I9B A;  2BG9 E;  5CO5 A;  4B5D A;  3IGQ A;  3WTK A;  4ZJS A;  2X00 D;  2XZ5 A;  3U8K A;  4BQT A;  3UQ4 A;  4UXU A;  2BYQ A;  3EI0 A;  4ZK4 A;  3ZDH A; 
#chains in the Genus database with same CATH topology
 5BRX A;  5J5G A;  4TWF A;  5KZU A;  5AFM B;  3UU4 A;  5CFB A;  2WZY A;  2XYS A;  2YKS A;  3TLS A;  2X00 A;  2C9T A;  2PGZ A;  5J5F A;  2XQ7 A;  5SYO A;  2XNU A;  2Y57 A;  4XHE A;  3WTI A;  4COF A;  3P50 A;  2YME A;  4IL4 A;  4XK9 A;  3UU3 A;  4HQP A;  4NPP A;  4QH5 A;  5AIN A;  5AFM A;  2UZ6 A;  4AFT A;  4F8H A;  4AFH A;  5AFH A;  3WTO A;  2Y7Y A;  5J5I A;  4QH1 A;  3SQ6 A;  4QAB A;  4ZR6 A;  2BYP A;  4QH4 A;  4TWH A;  5L47 A;  4BFQ A;  5BW2 A;  4TNV A;  5IUX A;  2BJ0 A;  2ZJV A;  3UUB A;  5HEG A;  3RIA A;  3U8L A;  4UM3 S;  4FRR A;  3WTM A;  2BYR A;  3ZKR A;  4HFC A;  4QAC A;  3JAD A;  3EHZ A;  3RQW A;  2XQ3 A;  5AFJ A;  3UU6 A;  5LXB A;  2BR7 A;  2YMD A;  3TLW A;  4D01 A;  4LMJ A;  4IL9 A;  4HFB A;  3RHW A;  2XNV A;  2XQ8 A;  3P4W A;  5HEU A;  1UW6 A;  1UX2 A;  2XQA A;  3UU5 A;  5TVC A;  4X5T A;  5L4E A;  4WV9 A;  3C84 A;  3PMZ A;  4LMK A;  4HFH A;  3RI5 A;  5KE4 A;  4ALX A;  2W8G A;  3EAM A;  2BYN A;  3UU8 A;  4LML A;  5AFL A;  4Z90 A;  3TLU A;  3C79 A;  5HCJ A;  3SH1 A;  3RIF A;  5J0Z A;  5AFK A;  5HEJ A;  4UM3 P;  4ZZC A;  3WTH A;  2XQ4 A;  5HEH A;  1UV6 A;  2BG9 B;  5FJV A;  2XYT A;  4UM3 A;  3WTJ A;  3U8N A;  2YN6 A;  3T4M A;  3GUA A;  3WTN A;  3RQU A;  3SIO A;  2ZJU A;  3TLT A;  3ZDG A;  4ZZB A;  2WN9 A;  2WNL A;  4UM1 A;  3JAE A;  5JME A;  2BG9 A;  4UY2 A;  5LG3 A;  2BYS A;  2PH9 A;  2BG9 C;  2XZ6 A;  2Y56 A;  3WIP A;  2WNJ A;  3LSV A;  2XQ5 A;  4HFD A;  3TLV A;  2YOE A;  3UQ7 A;  4IRE A;  3JAF A;  3SQ9 A;  4PIR A;  2QC1 B;  5BP0 A;  4EZ1 A;  4TNW A;  2BR8 A;  4HFE A;  4ILC A;  4DBM A;  4A97 A;  2XQ9 A;  2XQ6 A;  4ZJT A;  4ILA A;  5HCM A;  4AFG A;  2Y54 A;  3U8M A;  4Z91 A;  3PEO A;  4TWD A;  5AFN A;  4ZRU A;  4ZK1 A;  4HFI A;  4NZB A;  2Y58 A;  4A98 A;  4QAA A;  2XNT A;  3WTL A;  2VL0 A;  2WNC A;  3U8J A;  4ILB A;  5J5H A;  5HEO A;  2W8F A;  5L4H A;  1I9B A;  2BG9 E;  5CO5 A;  4B5D A;  3IGQ A;  3WTK A;  4ZJS A;  2X00 D;  2XZ5 A;  3U8K A;  4BQT A;  3UQ4 A;  4UXU A;  2BYQ A;  3EI0 A;  4ZK4 A;  3ZDH A; 
#chains in the Genus database with same CATH homology
 5BRX A;  5J5G A;  4TWF A;  5KZU A;  5AFM B;  3UU4 A;  5CFB A;  2WZY A;  2XYS A;  2YKS A;  3TLS A;  2X00 A;  2C9T A;  2PGZ A;  5J5F A;  2XQ7 A;  5SYO A;  2XNU A;  2Y57 A;  4XHE A;  3WTI A;  4COF A;  3P50 A;  2YME A;  4IL4 A;  4XK9 A;  3UU3 A;  4HQP A;  4NPP A;  4QH5 A;  5AIN A;  5AFM A;  2UZ6 A;  4AFT A;  4F8H A;  4AFH A;  5AFH A;  3WTO A;  2Y7Y A;  5J5I A;  4QH1 A;  3SQ6 A;  4QAB A;  4ZR6 A;  2BYP A;  4QH4 A;  4TWH A;  5L47 A;  4BFQ A;  5BW2 A;  4TNV A;  5IUX A;  2BJ0 A;  2ZJV A;  3UUB A;  5HEG A;  3RIA A;  3U8L A;  4UM3 S;  4FRR A;  3WTM A;  2BYR A;  3ZKR A;  4HFC A;  4QAC A;  3JAD A;  3EHZ A;  3RQW A;  2XQ3 A;  5AFJ A;  3UU6 A;  5LXB A;  2BR7 A;  2YMD A;  3TLW A;  4D01 A;  4LMJ A;  4IL9 A;  4HFB A;  3RHW A;  2XNV A;  2XQ8 A;  3P4W A;  5HEU A;  1UW6 A;  1UX2 A;  2XQA A;  3UU5 A;  5TVC A;  4X5T A;  5L4E A;  4WV9 A;  3C84 A;  3PMZ A;  4LMK A;  4HFH A;  3RI5 A;  5KE4 A;  4ALX A;  2W8G A;  3EAM A;  2BYN A;  3UU8 A;  4LML A;  5AFL A;  4Z90 A;  3TLU A;  3C79 A;  5HCJ A;  3SH1 A;  3RIF A;  5J0Z A;  5AFK A;  5HEJ A;  4UM3 P;  4ZZC A;  3WTH A;  2XQ4 A;  5HEH A;  1UV6 A;  2BG9 B;  5FJV A;  2XYT A;  4UM3 A;  3WTJ A;  3U8N A;  2YN6 A;  3T4M A;  3GUA A;  3WTN A;  3RQU A;  3SIO A;  2ZJU A;  3TLT A;  3ZDG A;  4ZZB A;  2WN9 A;  2WNL A;  4UM1 A;  3JAE A;  5JME A;  2BG9 A;  4UY2 A;  5LG3 A;  2BYS A;  2PH9 A;  2BG9 C;  2XZ6 A;  2Y56 A;  3WIP A;  2WNJ A;  3LSV A;  2XQ5 A;  4HFD A;  3TLV A;  2YOE A;  3UQ7 A;  4IRE A;  3JAF A;  3SQ9 A;  4PIR A;  2QC1 B;  5BP0 A;  4EZ1 A;  4TNW A;  2BR8 A;  4HFE A;  4ILC A;  4DBM A;  4A97 A;  2XQ9 A;  2XQ6 A;  4ZJT A;  4ILA A;  5HCM A;  4AFG A;  2Y54 A;  3U8M A;  4Z91 A;  3PEO A;  4TWD A;  5AFN A;  4ZRU A;  4ZK1 A;  4HFI A;  4NZB A;  2Y58 A;  4A98 A;  4QAA A;  2XNT A;  3WTL A;  2VL0 A;  2WNC A;  3U8J A;  4ILB A;  5J5H A;  5HEO A;  2W8F A;  5L4H A;  1I9B A;  2BG9 E;  5CO5 A;  4B5D A;  3IGQ A;  3WTK A;  4ZJS A;  2X00 D;  2XZ5 A;  3U8K A;  4BQT A;  3UQ4 A;  4UXU A;  2BYQ A;  3EI0 A;  4ZK4 A;  3ZDH A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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