4QACA

X-ray structure of acetylcholine binding protein (achbp) in complex with 4-(4-methylpiperidin-1-yl)-6-(4-(trifluoromethyl)phenyl)pyrimidin-2-amine
Total Genus 52
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
52
sequence length
213
structure length
209
Chain Sequence
DYKDDDDKLDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLARVVSDGEVLYMPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTDDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural basis for cooperative interactions of substituted 2-aminopyrimidines with the acetylcholine binding protein.
pubmed doi rcsb
molecule tags Acetylcholine-binding protein
source organism Lymnaea stagnalis
molecule keywords Acetylcholine-binding protein
total genus 52
structure length 209
sequence length 213
chains with identical sequence B, C, D, E, F, G, H, I, J
ec nomenclature
pdb deposition date 2014-05-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02931 Neur_chan_LBD Neurotransmitter-gated ion-channel ligand binding domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.170.10 Mainly Beta Distorted Sandwich Acetylcholine Binding Protein; Chain: A, Neurotransmitter-gated ion-channel ligand-binding domain 4qacA00
2XNTA 4WV9A 4ZR6A 5FJVA 4UM3S 5TVCA 4HFIA 3P4WA 4HFBA 5CFBA 4ZJTA 2WNJA 2XQ6A 3U8MA 4A98A 4PIRA 2WNCA 2XQ7A 5AINA 2BYQA 2VL0A 3JADA 4TWFA 4UM3P 5AFJA 1UX2A 1UW6A 3ZKRA 5HEGA 3RHWA 2QC1B 3UU4A 5HCMA 2XZ5A 4X5TA 5L4HA 3WTOA 2BYNA 5J5HA 2BG9A 5HCJA 2ZJUA 3UU3A 4BQTA 4QACA 5LG3A 5L47A 5LXBA 3TLTA 4FRRA 2BG9B 2YKSA 5J0ZA 4ILBA 4IREA 2PH9A 2XYSA 2YOEA 5AFMA 5AFKA 5IUXA 2YMDA 2C9TA 3JAFA 3SQ9A 3UUBA 5AFMB 2XQAA 2XQ4A 2XNVA 3PEOA 3TLVA 2BJ0A 4COFA 3U8JA 4ZZCA 3ZDGA 5HEUA 5BW2A 4HFEA 1I9BA 3SIOA 2ZJVA 4LMJA 3WTKA 2BR8A 3RI5A 4EZ1A 5KE4A 2PGZA 3WTHA 3WIPA 3EHZA 3TLSA 2XYTA 4QH5A 3SQ6A 2WN9A 1UV6A 5SYOA 3TLWA 5HEHA 4LMKA 4UM1A 2W8GA 4A97A 3RQWA 3JAEA 3U8KA 3ZDHA 2WZYA 2X00A 4IL9A 2BYSA 4ILCA 2Y57A 3GUAA 2WNLA 3EI0A 4TWHA 4ALXA 4AFGA 2W8FA 2XQ9A 4XK9A 3U8NA 4NPPA 4BFQA 4IL4A 2YN6A 2BG9E 5CO5A 3UU5A 2XQ5A 4HQPA 4Z91A 3WTIA 2Y54A 4NZBA 3C79A 3EAMA 2BR7A 4TNWA 4ZRUA 3SH1A 3RQUA 3WTMA 5L4EA 2UZ6A 4D01A 2XNUA 2XQ8A 3PMZA 5BP0A 3WTNA 4ZK4A 3UU8A 2Y58A 5J5FA 2BYPA 4AFTA 2XQ3A 4F8HA 4DBMA 4QAAA 5HEOA 3RIFA 5J5IA 3P50A 3TLUA 4HFHA 5HEJA 4Z90A 3WTJA 4LMLA 3T4MA 4ZK1A 4QH4A 2XZ6A 4QABA 3RIAA 5AFLA 4UM3A 3UQ7A 5JMEA 3UU6A 3IGQA 4ILAA 2Y56A 2YMEA 4B5DA 3UQ4A 4QH1A 4TNVA 4ZZBA 4UXUA 3WTLA 2X00D 3C84A 4HFDA 5J5GA 3LSVA 4ZJSA 2Y7YA 5BRXA 4TWDA 4UY2A 4XHEA 2BG9C 4AFHA 4HFCA 3U8LA 5AFHA 5KZUA 5AFNA 2BYRA
chains in the Genus database with same CATH superfamily
2XNTA 4WV9A 4ZR6A 5FJVA 4UM3S 5TVCA 4HFIA 3P4WA 4HFBA 5CFBA 4ZJTA 2WNJA 2XQ6A 3U8MA 4A98A 4PIRA 2WNCA 2XQ7A 5AINA 2BYQA 2VL0A 3JADA 4TWFA 4UM3P 5AFJA 1UX2A 1UW6A 3ZKRA 5HEGA 3RHWA 2QC1B 3UU4A 5HCMA 2XZ5A 4X5TA 5L4HA 3WTOA 2BYNA 5J5HA 2BG9A 5HCJA 2ZJUA 3UU3A 4BQTA 4QACA 5LG3A 5L47A 5LXBA 3TLTA 4FRRA 2BG9B 2YKSA 5J0ZA 4ILBA 4IREA 2PH9A 2XYSA 2YOEA 5AFMA 5AFKA 5IUXA 2YMDA 2C9TA 3JAFA 3SQ9A 3UUBA 5AFMB 2XQAA 2XQ4A 2XNVA 3PEOA 3TLVA 2BJ0A 4COFA 3U8JA 4ZZCA 3ZDGA 5HEUA 5BW2A 4HFEA 1I9BA 3SIOA 2ZJVA 4LMJA 3WTKA 2BR8A 3RI5A 4EZ1A 5KE4A 2PGZA 3WTHA 3WIPA 3EHZA 3TLSA 2XYTA 4QH5A 3SQ6A 2WN9A 1UV6A 5SYOA 3TLWA 5HEHA 4LMKA 4UM1A 2W8GA 4A97A 3RQWA 3JAEA 3U8KA 3ZDHA 2WZYA 2X00A 4IL9A 2BYSA 4ILCA 2Y57A 3GUAA 2WNLA 3EI0A 4TWHA 4ALXA 4AFGA 2W8FA 2XQ9A 4XK9A 3U8NA 4NPPA 4BFQA 4IL4A 2YN6A 2BG9E 5CO5A 3UU5A 2XQ5A 4HQPA 4Z91A 3WTIA 2Y54A 4NZBA 3C79A 3EAMA 2BR7A 4TNWA 4ZRUA 3SH1A 3RQUA 3WTMA 5L4EA 2UZ6A 4D01A 2XNUA 2XQ8A 3PMZA 5BP0A 3WTNA 4ZK4A 3UU8A 2Y58A 5J5FA 2BYPA 4AFTA 2XQ3A 4F8HA 4DBMA 4QAAA 5HEOA 3RIFA 5J5IA 3P50A 3TLUA 4HFHA 5HEJA 4Z90A 3WTJA 4LMLA 3T4MA 4ZK1A 4QH4A 2XZ6A 4QABA 3RIAA 5AFLA 4UM3A 3UQ7A 5JMEA 3UU6A 3IGQA 4ILAA 2Y56A 2YMEA 4B5DA 3UQ4A 4QH1A 4TNVA 4ZZBA 4UXUA 3WTLA 2X00D 3C84A 4HFDA 5J5GA 3LSVA 4ZJSA 2Y7YA 5BRXA 4TWDA 4UY2A 4XHEA 2BG9C 4AFHA 4HFCA 3U8LA 5AFHA 5KZUA 5AFNA 2BYRA
chains in the Genus database with same CATH topology
2XNTA 4WV9A 4ZR6A 5FJVA 4UM3S 5TVCA 4HFIA 3P4WA 4HFBA 5CFBA 4ZJTA 2WNJA 2XQ6A 3U8MA 4A98A 4PIRA 2WNCA 2XQ7A 5AINA 2BYQA 2VL0A 3JADA 4TWFA 4UM3P 5AFJA 1UX2A 1UW6A 3ZKRA 5HEGA 3RHWA 2QC1B 3UU4A 5HCMA 2XZ5A 4X5TA 5L4HA 3WTOA 2BYNA 5J5HA 2BG9A 5HCJA 2ZJUA 3UU3A 4BQTA 4QACA 5LG3A 5L47A 5LXBA 3TLTA 4FRRA 2BG9B 2YKSA 5J0ZA 4ILBA 4IREA 2PH9A 2XYSA 2YOEA 5AFMA 5AFKA 5IUXA 2YMDA 2C9TA 3JAFA 3SQ9A 3UUBA 5AFMB 2XQAA 2XQ4A 2XNVA 3PEOA 3TLVA 2BJ0A 4COFA 3U8JA 4ZZCA 3ZDGA 5HEUA 5BW2A 4HFEA 1I9BA 3SIOA 2ZJVA 4LMJA 3WTKA 2BR8A 3RI5A 4EZ1A 5KE4A 2PGZA 3WTHA 3WIPA 3EHZA 3TLSA 2XYTA 4QH5A 3SQ6A 2WN9A 1UV6A 5SYOA 3TLWA 5HEHA 4LMKA 4UM1A 2W8GA 4A97A 3RQWA 3JAEA 3U8KA 3ZDHA 2WZYA 2X00A 4IL9A 2BYSA 4ILCA 2Y57A 3GUAA 2WNLA 3EI0A 4TWHA 4ALXA 4AFGA 2W8FA 2XQ9A 4XK9A 3U8NA 4NPPA 4BFQA 4IL4A 2YN6A 2BG9E 5CO5A 3UU5A 2XQ5A 4HQPA 4Z91A 3WTIA 2Y54A 4NZBA 3C79A 3EAMA 2BR7A 4TNWA 4ZRUA 3SH1A 3RQUA 3WTMA 5L4EA 2UZ6A 4D01A 2XNUA 2XQ8A 3PMZA 5BP0A 3WTNA 4ZK4A 3UU8A 2Y58A 5J5FA 2BYPA 4AFTA 2XQ3A 4F8HA 4DBMA 4QAAA 5HEOA 3RIFA 5J5IA 3P50A 3TLUA 4HFHA 5HEJA 4Z90A 3WTJA 4LMLA 3T4MA 4ZK1A 4QH4A 2XZ6A 4QABA 3RIAA 5AFLA 4UM3A 3UQ7A 5JMEA 3UU6A 3IGQA 4ILAA 2Y56A 2YMEA 4B5DA 3UQ4A 4QH1A 4TNVA 4ZZBA 4UXUA 3WTLA 2X00D 3C84A 4HFDA 5J5GA 3LSVA 4ZJSA 2Y7YA 5BRXA 4TWDA 4UY2A 4XHEA 2BG9C 4AFHA 4HFCA 3U8LA 5AFHA 5KZUA 5AFNA 2BYRA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2XNT A;  4WV9 A;  4ZR6 A;  5FJV A;  4UM3 S;  5TVC A;  4HFI A;  3P4W A;  4HFB A;  5CFB A;  4ZJT A;  2WNJ A;  2XQ6 A;  3U8M A;  4A98 A;  4PIR A;  2WNC A;  2XQ7 A;  5AIN A;  2BYQ A;  2VL0 A;  3JAD A;  4TWF A;  4UM3 P;  5AFJ A;  1UX2 A;  1UW6 A;  3ZKR A;  5HEG A;  3RHW A;  2QC1 B;  3UU4 A;  5HCM A;  2XZ5 A;  4X5T A;  5L4H A;  3WTO A;  2BYN A;  5J5H A;  2BG9 A;  5HCJ A;  2ZJU A;  3UU3 A;  4BQT A;  4QAC A;  5LG3 A;  5L47 A;  5LXB A;  3TLT A;  4FRR A;  2BG9 B;  2YKS A;  5J0Z A;  4ILB A;  4IRE A;  2PH9 A;  2XYS A;  2YOE A;  5AFM A;  5AFK A;  5IUX A;  2YMD A;  2C9T A;  3JAF A;  3SQ9 A;  3UUB A;  5AFM B;  2XQA A;  2XQ4 A;  2XNV A;  3PEO A;  3TLV A;  2BJ0 A;  4COF A;  3U8J A;  4ZZC A;  3ZDG A;  5HEU A;  5BW2 A;  4HFE A;  1I9B A;  3SIO A;  2ZJV A;  4LMJ A;  3WTK A;  2BR8 A;  3RI5 A;  4EZ1 A;  5KE4 A;  2PGZ A;  3WTH A;  3WIP A;  3EHZ A;  3TLS A;  2XYT A;  4QH5 A;  3SQ6 A;  2WN9 A;  1UV6 A;  5SYO A;  3TLW A;  5HEH A;  4LMK A;  4UM1 A;  2W8G A;  4A97 A;  3RQW A;  3JAE A;  3U8K A;  3ZDH A;  2WZY A;  2X00 A;  4IL9 A;  2BYS A;  4ILC A;  2Y57 A;  3GUA A;  2WNL A;  3EI0 A;  4TWH A;  4ALX A;  4AFG A;  2W8F A;  2XQ9 A;  4XK9 A;  3U8N A;  4NPP A;  4BFQ A;  4IL4 A;  2YN6 A;  2BG9 E;  5CO5 A;  3UU5 A;  2XQ5 A;  4HQP A;  4Z91 A;  3WTI A;  2Y54 A;  4NZB A;  3C79 A;  3EAM A;  2BR7 A;  4TNW A;  4ZRU A;  3SH1 A;  3RQU A;  3WTM A;  5L4E A;  2UZ6 A;  4D01 A;  2XNU A;  2XQ8 A;  3PMZ A;  5BP0 A;  3WTN A;  4ZK4 A;  3UU8 A;  2Y58 A;  5J5F A;  2BYP A;  4AFT A;  2XQ3 A;  4F8H A;  4DBM A;  4QAA A;  5HEO A;  3RIF A;  5J5I A;  3P50 A;  3TLU A;  4HFH A;  5HEJ A;  4Z90 A;  3WTJ A;  4LML A;  3T4M A;  4ZK1 A;  4QH4 A;  2XZ6 A;  4QAB A;  3RIA A;  5AFL A;  4UM3 A;  3UQ7 A;  5JME A;  3UU6 A;  3IGQ A;  4ILA A;  2Y56 A;  2YME A;  4B5D A;  3UQ4 A;  4QH1 A;  4TNV A;  4ZZB A;  4UXU A;  3WTL A;  2X00 D;  3C84 A;  4HFD A;  5J5G A;  3LSV A;  4ZJS A;  2Y7Y A;  5BRX A;  4TWD A;  4UY2 A;  4XHE A;  2BG9 C;  4AFH A;  4HFC A;  3U8L A;  5AFH A;  5KZU A;  5AFN A;  2BYR A; 
#chains in the Genus database with same CATH topology
 2XNT A;  4WV9 A;  4ZR6 A;  5FJV A;  4UM3 S;  5TVC A;  4HFI A;  3P4W A;  4HFB A;  5CFB A;  4ZJT A;  2WNJ A;  2XQ6 A;  3U8M A;  4A98 A;  4PIR A;  2WNC A;  2XQ7 A;  5AIN A;  2BYQ A;  2VL0 A;  3JAD A;  4TWF A;  4UM3 P;  5AFJ A;  1UX2 A;  1UW6 A;  3ZKR A;  5HEG A;  3RHW A;  2QC1 B;  3UU4 A;  5HCM A;  2XZ5 A;  4X5T A;  5L4H A;  3WTO A;  2BYN A;  5J5H A;  2BG9 A;  5HCJ A;  2ZJU A;  3UU3 A;  4BQT A;  4QAC A;  5LG3 A;  5L47 A;  5LXB A;  3TLT A;  4FRR A;  2BG9 B;  2YKS A;  5J0Z A;  4ILB A;  4IRE A;  2PH9 A;  2XYS A;  2YOE A;  5AFM A;  5AFK A;  5IUX A;  2YMD A;  2C9T A;  3JAF A;  3SQ9 A;  3UUB A;  5AFM B;  2XQA A;  2XQ4 A;  2XNV A;  3PEO A;  3TLV A;  2BJ0 A;  4COF A;  3U8J A;  4ZZC A;  3ZDG A;  5HEU A;  5BW2 A;  4HFE A;  1I9B A;  3SIO A;  2ZJV A;  4LMJ A;  3WTK A;  2BR8 A;  3RI5 A;  4EZ1 A;  5KE4 A;  2PGZ A;  3WTH A;  3WIP A;  3EHZ A;  3TLS A;  2XYT A;  4QH5 A;  3SQ6 A;  2WN9 A;  1UV6 A;  5SYO A;  3TLW A;  5HEH A;  4LMK A;  4UM1 A;  2W8G A;  4A97 A;  3RQW A;  3JAE A;  3U8K A;  3ZDH A;  2WZY A;  2X00 A;  4IL9 A;  2BYS A;  4ILC A;  2Y57 A;  3GUA A;  2WNL A;  3EI0 A;  4TWH A;  4ALX A;  4AFG A;  2W8F A;  2XQ9 A;  4XK9 A;  3U8N A;  4NPP A;  4BFQ A;  4IL4 A;  2YN6 A;  2BG9 E;  5CO5 A;  3UU5 A;  2XQ5 A;  4HQP A;  4Z91 A;  3WTI A;  2Y54 A;  4NZB A;  3C79 A;  3EAM A;  2BR7 A;  4TNW A;  4ZRU A;  3SH1 A;  3RQU A;  3WTM A;  5L4E A;  2UZ6 A;  4D01 A;  2XNU A;  2XQ8 A;  3PMZ A;  5BP0 A;  3WTN A;  4ZK4 A;  3UU8 A;  2Y58 A;  5J5F A;  2BYP A;  4AFT A;  2XQ3 A;  4F8H A;  4DBM A;  4QAA A;  5HEO A;  3RIF A;  5J5I A;  3P50 A;  3TLU A;  4HFH A;  5HEJ A;  4Z90 A;  3WTJ A;  4LML A;  3T4M A;  4ZK1 A;  4QH4 A;  2XZ6 A;  4QAB A;  3RIA A;  5AFL A;  4UM3 A;  3UQ7 A;  5JME A;  3UU6 A;  3IGQ A;  4ILA A;  2Y56 A;  2YME A;  4B5D A;  3UQ4 A;  4QH1 A;  4TNV A;  4ZZB A;  4UXU A;  3WTL A;  2X00 D;  3C84 A;  4HFD A;  5J5G A;  3LSV A;  4ZJS A;  2Y7Y A;  5BRX A;  4TWD A;  4UY2 A;  4XHE A;  2BG9 C;  4AFH A;  4HFC A;  3U8L A;  5AFH A;  5KZU A;  5AFN A;  2BYR A; 
#chains in the Genus database with same CATH homology
 2XNT A;  4WV9 A;  4ZR6 A;  5FJV A;  4UM3 S;  5TVC A;  4HFI A;  3P4W A;  4HFB A;  5CFB A;  4ZJT A;  2WNJ A;  2XQ6 A;  3U8M A;  4A98 A;  4PIR A;  2WNC A;  2XQ7 A;  5AIN A;  2BYQ A;  2VL0 A;  3JAD A;  4TWF A;  4UM3 P;  5AFJ A;  1UX2 A;  1UW6 A;  3ZKR A;  5HEG A;  3RHW A;  2QC1 B;  3UU4 A;  5HCM A;  2XZ5 A;  4X5T A;  5L4H A;  3WTO A;  2BYN A;  5J5H A;  2BG9 A;  5HCJ A;  2ZJU A;  3UU3 A;  4BQT A;  4QAC A;  5LG3 A;  5L47 A;  5LXB A;  3TLT A;  4FRR A;  2BG9 B;  2YKS A;  5J0Z A;  4ILB A;  4IRE A;  2PH9 A;  2XYS A;  2YOE A;  5AFM A;  5AFK A;  5IUX A;  2YMD A;  2C9T A;  3JAF A;  3SQ9 A;  3UUB A;  5AFM B;  2XQA A;  2XQ4 A;  2XNV A;  3PEO A;  3TLV A;  2BJ0 A;  4COF A;  3U8J A;  4ZZC A;  3ZDG A;  5HEU A;  5BW2 A;  4HFE A;  1I9B A;  3SIO A;  2ZJV A;  4LMJ A;  3WTK A;  2BR8 A;  3RI5 A;  4EZ1 A;  5KE4 A;  2PGZ A;  3WTH A;  3WIP A;  3EHZ A;  3TLS A;  2XYT A;  4QH5 A;  3SQ6 A;  2WN9 A;  1UV6 A;  5SYO A;  3TLW A;  5HEH A;  4LMK A;  4UM1 A;  2W8G A;  4A97 A;  3RQW A;  3JAE A;  3U8K A;  3ZDH A;  2WZY A;  2X00 A;  4IL9 A;  2BYS A;  4ILC A;  2Y57 A;  3GUA A;  2WNL A;  3EI0 A;  4TWH A;  4ALX A;  4AFG A;  2W8F A;  2XQ9 A;  4XK9 A;  3U8N A;  4NPP A;  4BFQ A;  4IL4 A;  2YN6 A;  2BG9 E;  5CO5 A;  3UU5 A;  2XQ5 A;  4HQP A;  4Z91 A;  3WTI A;  2Y54 A;  4NZB A;  3C79 A;  3EAM A;  2BR7 A;  4TNW A;  4ZRU A;  3SH1 A;  3RQU A;  3WTM A;  5L4E A;  2UZ6 A;  4D01 A;  2XNU A;  2XQ8 A;  3PMZ A;  5BP0 A;  3WTN A;  4ZK4 A;  3UU8 A;  2Y58 A;  5J5F A;  2BYP A;  4AFT A;  2XQ3 A;  4F8H A;  4DBM A;  4QAA A;  5HEO A;  3RIF A;  5J5I A;  3P50 A;  3TLU A;  4HFH A;  5HEJ A;  4Z90 A;  3WTJ A;  4LML A;  3T4M A;  4ZK1 A;  4QH4 A;  2XZ6 A;  4QAB A;  3RIA A;  5AFL A;  4UM3 A;  3UQ7 A;  5JME A;  3UU6 A;  3IGQ A;  4ILA A;  2Y56 A;  2YME A;  4B5D A;  3UQ4 A;  4QH1 A;  4TNV A;  4ZZB A;  4UXU A;  3WTL A;  2X00 D;  3C84 A;  4HFD A;  5J5G A;  3LSV A;  4ZJS A;  2Y7Y A;  5BRX A;  4TWD A;  4UY2 A;  4XHE A;  2BG9 C;  4AFH A;  4HFC A;  3U8L A;  5AFH A;  5KZU A;  5AFN A;  2BYR A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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