4UM1 | Genus

Total Genus 42

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	42
sequence length	204
structure length	200
Chain Sequence	LDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLAHVVSDGEVQYTPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTTDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKK

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

molecule tags	Signaling protein
source organism	Lymnaea stagnalis
publication title	Achbp Engineered to Mimic the Alpha4-Alpha4 Binding Pocket in Alpha4Beta2 Nicotinic Acetylcholine Receptors Reveals Interface Specific Interactions Important for Binding and Activity pubmed doi rcsb
molecule keywords	ACETYLCHOLINE-BINDING PROTEIN
total genus	42
structure length	200
sequence length	204
chains with identical sequence	B, C, D, E
ec nomenclature
pdb deposition date	2014-05-14

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF02931	Neur_chan_LBD	Neurotransmitter-gated ion-channel ligand binding domain

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
2.70.170.10	Mainly Beta	Distorted Sandwich	Acetylcholine Binding Protein; Chain: A,	Neurotransmitter-gated ion-channel ligand-binding domain	4um1A00

5HEHA 3TLSA 4XK9A 3RQUA 5IUXA 5KZUA 4COFA 2XQ3A 3UU8A 5J5HA 4D01A 2WNCA 5SYOA 5J5FA 2BR7A 4HFHA 3ZDGA 3RIFA 4NZBA 3UU4A 4ZZBA 4TNWA 2QC1B 4XHEA 4UY2A 2WNJA 3U8NA 2Y7YA 5LG3A 2VL0A 2BG9C 4TWDA 2BG9B 3P50A 2BYSA 3RQWA 2WNLA 2XYSA 3RI5A 2XQ4A 3UU6A 2BG9A 4HFCA 4TNVA 4IL4A 3RHWA 2XZ6A 5LXBA 4HFBA 3JAFA 3SH1A 4HQPA 5FJVA 2XNTA 4UXUA 4ZK4A 3U8MA 3WTJA 4BFQA 5HCJA 2C9TA 2PH9A 5L4EA 3GUAA 4UM3A 2YOEA 3P4WA 3PEOA 3ZDHA 3EHZA 5AFLA 4DBMA 4QH1A 3U8KA 4A98A 5AFHA 4QAAA 4UM1A 4QH5A 3ZKRA 2Y57A 1UX2A 4ZR6A 3UU5A 1I9BA 5AINA 4ILCA 4WV9A 4Z90A 4Z91A 2BG9E 2YN6A 2X00D 2BYQA 4ZK1A 3EI0A 2XQAA 5HEUA 2YMDA 3SQ6A 4QABA 3U8LA 3SIOA 2Y58A 3C84A 4NPPA 3U8JA 3WTIA 2BR8A 2YMEA 4PIRA 4AFGA 5AFMB 2W8FA 1UV6A 2ZJVA 3WTNA 3WTOA 4TWHA 2XNVA 2XZ5A 4IREA 5AFMA 5HCMA 2Y54A 3IGQA 5CO5A 5L4HA 4A97A 5AFKA 4QH4A 3WIPA 5AFNA 2X00A 3SQ9A 5CFBA 3EAMA 4UM3P 3TLVA 2XYTA 4AFTA 4EZ1A 5JMEA 3TLTA 4X5TA 4ALXA 4UM3S 3WTMA 4ZZCA 3JAEA 4LMJA 2XQ5A 3T4MA 3UQ4A 4ILAA 4IL9A 2YKSA 1UW6A 3C79A 4BQTA 5J0ZA 3JADA 5J5GA 2BYPA 4ZJSA 3WTKA 5BW2A 5KE4A 2Y56A 4HFDA 4LMKA 5HEGA 4ILBA 3RIAA 2WZYA 3LSVA 5TVCA 2W8GA 3UQ7A 4AFHA 2XNUA 4LMLA 5AFJA 2XQ6A 3PMZA 2WN9A 2XQ8A 4F8HA 5BP0A 5J5IA 3WTLA 4HFIA 3UU3A 3UUBA 4B5DA 2BJ0A 3TLWA 4TWFA 2PGZA 5HEOA 2XQ7A 3WTHA 2BYNA 2BYRA 2ZJUA 5BRXA 5L47A 2UZ6A 5HEJA 4HFEA 2XQ9A 3TLUA 4ZJTA 4QACA 4FRRA 4ZRUA
chains in the Genus database with same CATH superfamily

#chains in the Genus database with same CATH superfamily
 5HEH A;  3TLS A;  4XK9 A;  3RQU A;  5IUX A;  5KZU A;  4COF A;  2XQ3 A;  3UU8 A;  5J5H A;  4D01 A;  2WNC A;  5SYO A;  5J5F A;  2BR7 A;  4HFH A;  3ZDG A;  3RIF A;  4NZB A;  3UU4 A;  4ZZB A;  4TNW A;  2QC1 B;  4XHE A;  4UY2 A;  2WNJ A;  3U8N A;  2Y7Y A;  5LG3 A;  2VL0 A;  2BG9 C;  4TWD A;  2BG9 B;  3P50 A;  2BYS A;  3RQW A;  2WNL A;  2XYS A;  3RI5 A;  2XQ4 A;  3UU6 A;  2BG9 A;  4HFC A;  4TNV A;  4IL4 A;  3RHW A;  2XZ6 A;  5LXB A;  4HFB A;  3JAF A;  3SH1 A;  4HQP A;  5FJV A;  2XNT A;  4UXU A;  4ZK4 A;  3U8M A;  3WTJ A;  4BFQ A;  5HCJ A;  2C9T A;  2PH9 A;  5L4E A;  3GUA A;  4UM3 A;  2YOE A;  3P4W A;  3PEO A;  3ZDH A;  3EHZ A;  5AFL A;  4DBM A;  4QH1 A;  3U8K A;  4A98 A;  5AFH A;  4QAA A;  4UM1 A;  4QH5 A;  3ZKR A;  2Y57 A;  1UX2 A;  4ZR6 A;  3UU5 A;  1I9B A;  5AIN A;  4ILC A;  4WV9 A;  4Z90 A;  4Z91 A;  2BG9 E;  2YN6 A;  2X00 D;  2BYQ A;  4ZK1 A;  3EI0 A;  2XQA A;  5HEU A;  2YMD A;  3SQ6 A;  4QAB A;  3U8L A;  3SIO A;  2Y58 A;  3C84 A;  4NPP A;  3U8J A;  3WTI A;  2BR8 A;  2YME A;  4PIR A;  4AFG A;  5AFM B;  2W8F A;  1UV6 A;  2ZJV A;  3WTN A;  3WTO A;  4TWH A;  2XNV A;  2XZ5 A;  4IRE A;  5AFM A;  5HCM A;  2Y54 A;  3IGQ A;  5CO5 A;  5L4H A;  4A97 A;  5AFK A;  4QH4 A;  3WIP A;  5AFN A;  2X00 A;  3SQ9 A;  5CFB A;  3EAM A;  4UM3 P;  3TLV A;  2XYT A;  4AFT A;  4EZ1 A;  5JME A;  3TLT A;  4X5T A;  4ALX A;  4UM3 S;  3WTM A;  4ZZC A;  3JAE A;  4LMJ A;  2XQ5 A;  3T4M A;  3UQ4 A;  4ILA A;  4IL9 A;  2YKS A;  1UW6 A;  3C79 A;  4BQT A;  5J0Z A;  3JAD A;  5J5G A;  2BYP A;  4ZJS A;  3WTK A;  5BW2 A;  5KE4 A;  2Y56 A;  4HFD A;  4LMK A;  5HEG A;  4ILB A;  3RIA A;  2WZY A;  3LSV A;  5TVC A;  2W8G A;  3UQ7 A;  4AFH A;  2XNU A;  4LML A;  5AFJ A;  2XQ6 A;  3PMZ A;  2WN9 A;  2XQ8 A;  4F8H A;  5BP0 A;  5J5I A;  3WTL A;  4HFI A;  3UU3 A;  3UUB A;  4B5D A;  2BJ0 A;  3TLW A;  4TWF A;  2PGZ A;  5HEO A;  2XQ7 A;  3WTH A;  2BYN A;  2BYR A;  2ZJU A;  5BRX A;  5L47 A;  2UZ6 A;  5HEJ A;  4HFE A;  2XQ9 A;  3TLU A;  4ZJT A;  4QAC A;  4FRR A;  4ZRU A; 
#chains in the Genus database with same CATH topology
 5HEH A;  3TLS A;  4XK9 A;  3RQU A;  5IUX A;  5KZU A;  4COF A;  2XQ3 A;  3UU8 A;  5J5H A;  4D01 A;  2WNC A;  5SYO A;  5J5F A;  2BR7 A;  4HFH A;  3ZDG A;  3RIF A;  4NZB A;  3UU4 A;  4ZZB A;  4TNW A;  2QC1 B;  4XHE A;  4UY2 A;  2WNJ A;  3U8N A;  2Y7Y A;  5LG3 A;  2VL0 A;  2BG9 C;  4TWD A;  2BG9 B;  3P50 A;  2BYS A;  3RQW A;  2WNL A;  2XYS A;  3RI5 A;  2XQ4 A;  3UU6 A;  2BG9 A;  4HFC A;  4TNV A;  4IL4 A;  3RHW A;  2XZ6 A;  5LXB A;  4HFB A;  3JAF A;  3SH1 A;  4HQP A;  5FJV A;  2XNT A;  4UXU A;  4ZK4 A;  3U8M A;  3WTJ A;  4BFQ A;  5HCJ A;  2C9T A;  2PH9 A;  5L4E A;  3GUA A;  4UM3 A;  2YOE A;  3P4W A;  3PEO A;  3ZDH A;  3EHZ A;  5AFL A;  4DBM A;  4QH1 A;  3U8K A;  4A98 A;  5AFH A;  4QAA A;  4UM1 A;  4QH5 A;  3ZKR A;  2Y57 A;  1UX2 A;  4ZR6 A;  3UU5 A;  1I9B A;  5AIN A;  4ILC A;  4WV9 A;  4Z90 A;  4Z91 A;  2BG9 E;  2YN6 A;  2X00 D;  2BYQ A;  4ZK1 A;  3EI0 A;  2XQA A;  5HEU A;  2YMD A;  3SQ6 A;  4QAB A;  3U8L A;  3SIO A;  2Y58 A;  3C84 A;  4NPP A;  3U8J A;  3WTI A;  2BR8 A;  2YME A;  4PIR A;  4AFG A;  5AFM B;  2W8F A;  1UV6 A;  2ZJV A;  3WTN A;  3WTO A;  4TWH A;  2XNV A;  2XZ5 A;  4IRE A;  5AFM A;  5HCM A;  2Y54 A;  3IGQ A;  5CO5 A;  5L4H A;  4A97 A;  5AFK A;  4QH4 A;  3WIP A;  5AFN A;  2X00 A;  3SQ9 A;  5CFB A;  3EAM A;  4UM3 P;  3TLV A;  2XYT A;  4AFT A;  4EZ1 A;  5JME A;  3TLT A;  4X5T A;  4ALX A;  4UM3 S;  3WTM A;  4ZZC A;  3JAE A;  4LMJ A;  2XQ5 A;  3T4M A;  3UQ4 A;  4ILA A;  4IL9 A;  2YKS A;  1UW6 A;  3C79 A;  4BQT A;  5J0Z A;  3JAD A;  5J5G A;  2BYP A;  4ZJS A;  3WTK A;  5BW2 A;  5KE4 A;  2Y56 A;  4HFD A;  4LMK A;  5HEG A;  4ILB A;  3RIA A;  2WZY A;  3LSV A;  5TVC A;  2W8G A;  3UQ7 A;  4AFH A;  2XNU A;  4LML A;  5AFJ A;  2XQ6 A;  3PMZ A;  2WN9 A;  2XQ8 A;  4F8H A;  5BP0 A;  5J5I A;  3WTL A;  4HFI A;  3UU3 A;  3UUB A;  4B5D A;  2BJ0 A;  3TLW A;  4TWF A;  2PGZ A;  5HEO A;  2XQ7 A;  3WTH A;  2BYN A;  2BYR A;  2ZJU A;  5BRX A;  5L47 A;  2UZ6 A;  5HEJ A;  4HFE A;  2XQ9 A;  3TLU A;  4ZJT A;  4QAC A;  4FRR A;  4ZRU A; 
#chains in the Genus database with same CATH homology
 5HEH A;  3TLS A;  4XK9 A;  3RQU A;  5IUX A;  5KZU A;  4COF A;  2XQ3 A;  3UU8 A;  5J5H A;  4D01 A;  2WNC A;  5SYO A;  5J5F A;  2BR7 A;  4HFH A;  3ZDG A;  3RIF A;  4NZB A;  3UU4 A;  4ZZB A;  4TNW A;  2QC1 B;  4XHE A;  4UY2 A;  2WNJ A;  3U8N A;  2Y7Y A;  5LG3 A;  2VL0 A;  2BG9 C;  4TWD A;  2BG9 B;  3P50 A;  2BYS A;  3RQW A;  2WNL A;  2XYS A;  3RI5 A;  2XQ4 A;  3UU6 A;  2BG9 A;  4HFC A;  4TNV A;  4IL4 A;  3RHW A;  2XZ6 A;  5LXB A;  4HFB A;  3JAF A;  3SH1 A;  4HQP A;  5FJV A;  2XNT A;  4UXU A;  4ZK4 A;  3U8M A;  3WTJ A;  4BFQ A;  5HCJ A;  2C9T A;  2PH9 A;  5L4E A;  3GUA A;  4UM3 A;  2YOE A;  3P4W A;  3PEO A;  3ZDH A;  3EHZ A;  5AFL A;  4DBM A;  4QH1 A;  3U8K A;  4A98 A;  5AFH A;  4QAA A;  4UM1 A;  4QH5 A;  3ZKR A;  2Y57 A;  1UX2 A;  4ZR6 A;  3UU5 A;  1I9B A;  5AIN A;  4ILC A;  4WV9 A;  4Z90 A;  4Z91 A;  2BG9 E;  2YN6 A;  2X00 D;  2BYQ A;  4ZK1 A;  3EI0 A;  2XQA A;  5HEU A;  2YMD A;  3SQ6 A;  4QAB A;  3U8L A;  3SIO A;  2Y58 A;  3C84 A;  4NPP A;  3U8J A;  3WTI A;  2BR8 A;  2YME A;  4PIR A;  4AFG A;  5AFM B;  2W8F A;  1UV6 A;  2ZJV A;  3WTN A;  3WTO A;  4TWH A;  2XNV A;  2XZ5 A;  4IRE A;  5AFM A;  5HCM A;  2Y54 A;  3IGQ A;  5CO5 A;  5L4H A;  4A97 A;  5AFK A;  4QH4 A;  3WIP A;  5AFN A;  2X00 A;  3SQ9 A;  5CFB A;  3EAM A;  4UM3 P;  3TLV A;  2XYT A;  4AFT A;  4EZ1 A;  5JME A;  3TLT A;  4X5T A;  4ALX A;  4UM3 S;  3WTM A;  4ZZC A;  3JAE A;  4LMJ A;  2XQ5 A;  3T4M A;  3UQ4 A;  4ILA A;  4IL9 A;  2YKS A;  1UW6 A;  3C79 A;  4BQT A;  5J0Z A;  3JAD A;  5J5G A;  2BYP A;  4ZJS A;  3WTK A;  5BW2 A;  5KE4 A;  2Y56 A;  4HFD A;  4LMK A;  5HEG A;  4ILB A;  3RIA A;  2WZY A;  3LSV A;  5TVC A;  2W8G A;  3UQ7 A;  4AFH A;  2XNU A;  4LML A;  5AFJ A;  2XQ6 A;  3PMZ A;  2WN9 A;  2XQ8 A;  4F8H A;  5BP0 A;  5J5I A;  3WTL A;  4HFI A;  3UU3 A;  3UUB A;  4B5D A;  2BJ0 A;  3TLW A;  4TWF A;  2PGZ A;  5HEO A;  2XQ7 A;  3WTH A;  2BYN A;  2BYR A;  2ZJU A;  5BRX A;  5L47 A;  2UZ6 A;  5HEJ A;  4HFE A;  2XQ9 A;  3TLU A;  4ZJT A;  4QAC A;  4FRR A;  4ZRU A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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4UM1A

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations