4ZK4 | Genus

Total Genus 48

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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	48
sequence length	215
structure length	211
Chain Sequence	DDDKLHSQANLMRLKSDLFNYPGPTKDDPLTVTLGFTLQDIVKADSSTNEVDLVYWEQQRWKLNSLMWDPNEYGNITDFRTSAADIWTPDITAYSSTRPVQVLSPQIAVVTHDGSVMFIPAQRLSFMCDPTGVDSEEGATCAVKFGSWVYSGFEIDLKTDTDQVDLSSYYASSKYEILSATQYKHDIKYNCCEEIYPDVVLVVKFRERRAG

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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

molecule tags	Acetylcholine binding protein
source organism	Aplysia californica
publication title	Crystal structure of a chimeric acetylcholine binding protein from Aplysia californica (Ac-AChBP) containing loop C from the human alpha 3 nicotinic acetylcholine receptor in complex with 7-(5-isopropoxy-pyridin-3-yl)-1-methyl-1,7-diaza-spiro[4.4]nonane. rcsb
molecule keywords	soluble acetylcholine receptor, neuronal acetylcholine recep
total genus	48
structure length	211
sequence length	215
chains with identical sequence	B, C, D, E
ec nomenclature
pdb deposition date	2015-04-29

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF02931	Neur_chan_LBD	Neurotransmitter-gated ion-channel ligand binding domain
A	PF02931	Neur_chan_LBD	Neurotransmitter-gated ion-channel ligand binding domain

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
2.70.170.10	Mainly Beta	Distorted Sandwich	Acetylcholine Binding Protein; Chain: A,	Neurotransmitter-gated ion-channel ligand-binding domain	4zk4A00

4ZZCA 5HEGA 2Y56A 2YKSA 4FRRA 2YMEA 3U8NA 2X00D 3UQ4A 2BG9A 3WTMA 5HEUA 3GUAA 3U8MA 4ILAA 5FJVA 5L4HA 3ZKRA 5AFMA 3WIPA 2PGZA 3SIOA 3UU6A 2BJ0A 2Y58A 5J5FA 2YMDA 2WNJA 3UUBA 3RHWA 4AFTA 4A98A 3UU3A 2BYSA 3SQ9A 4HFBA 4HFHA 4NZBA 4UY2A 2ZJUA 4ILCA 4Z90A 3P4WA 4HQPA 3WTJA 5KZUA 2BG9C 4BFQA 2BYPA 4B5DA 2XQ7A 3JADA 2X00A 3WTNA 4ALXA 2XQAA 3WTKA 4ZK1A 4HFEA 2WNLA 5TVCA 3U8KA 4QH1A 3U8JA 3TLWA 2Y57A 2Y54A 2XZ5A 2BYNA 2BYQA 5CFBA 4HFDA 4TWDA 4UM3P 4UXUA 2XNVA 4ILBA 1UX2A 4TNVA 5AFKA 3RIFA 1I9BA 4Z91A 4IL9A 5BP0A 4QH5A 4ZZBA 3UU5A 4EZ1A 5KE4A 4QAAA 2XNTA 2YN6A 5SYOA 5J5IA 2XQ6A 4PIRA 4COFA 2XZ6A 2YOEA 5LXBA 3RI5A 5J5HA 4ZK4A 3TLUA 5HCMA 4TNWA 4ZR6A 2BG9B 3SH1A 3C79A 5LG3A 2BR7A 3RQUA 5AFMB 2XNUA 1UW6A 4DBMA 3PEOA 2XQ4A 3LSVA 2BG9E 2BYRA 5BRXA 2C9TA 4LMLA 3UU4A 3WTLA 4ZJTA 3JAEA 2VL0A 5HEHA 3ZDHA 4NPPA 5AFHA 5J0ZA 5AFJA 4LMJA 2WNCA 3EI0A 3UU8A 5JMEA 4UM1A 3TLVA 4TWHA 2UZ6A 4IREA 5CO5A 5J5GA 3RIAA 2QC1B 4X5TA 4TWFA 4A97A 2XYSA 4LMKA 3T4MA 4F8HA 4WV9A 3EAMA 4IL4A 4UM3S 4QABA 4QACA 4HFCA 2XQ5A 2W8GA 4XK9A 3U8LA 3ZDGA 4XHEA 5IUXA 5L4EA 3WTHA 4ZRUA 5HEOA 3WTOA 2BR8A 2Y7YA 4AFHA 2PH9A 2XQ3A 5AFLA 4QH4A 3JAFA 3TLTA 5L47A 4BQTA 2ZJVA 3EHZA 2WZYA 4ZJSA 3UQ7A 3PMZA 3TLSA 3RQWA 4UM3A 2XQ9A 2WN9A 4HFIA 4D01A 2XQ8A 5AFNA 3P50A 3WTIA 3SQ6A 2W8FA 3C84A 4AFGA 2XYTA 5HCJA 1UV6A 5BW2A 3IGQA 5AINA 5HEJA
chains in the Genus database with same CATH superfamily

#chains in the Genus database with same CATH superfamily
 4ZZC A;  5HEG A;  2Y56 A;  2YKS A;  4FRR A;  2YME A;  3U8N A;  2X00 D;  3UQ4 A;  2BG9 A;  3WTM A;  5HEU A;  3GUA A;  3U8M A;  4ILA A;  5FJV A;  5L4H A;  3ZKR A;  5AFM A;  3WIP A;  2PGZ A;  3SIO A;  3UU6 A;  2BJ0 A;  2Y58 A;  5J5F A;  2YMD A;  2WNJ A;  3UUB A;  3RHW A;  4AFT A;  4A98 A;  3UU3 A;  2BYS A;  3SQ9 A;  4HFB A;  4HFH A;  4NZB A;  4UY2 A;  2ZJU A;  4ILC A;  4Z90 A;  3P4W A;  4HQP A;  3WTJ A;  5KZU A;  2BG9 C;  4BFQ A;  2BYP A;  4B5D A;  2XQ7 A;  3JAD A;  2X00 A;  3WTN A;  4ALX A;  2XQA A;  3WTK A;  4ZK1 A;  4HFE A;  2WNL A;  5TVC A;  3U8K A;  4QH1 A;  3U8J A;  3TLW A;  2Y57 A;  2Y54 A;  2XZ5 A;  2BYN A;  2BYQ A;  5CFB A;  4HFD A;  4TWD A;  4UM3 P;  4UXU A;  2XNV A;  4ILB A;  1UX2 A;  4TNV A;  5AFK A;  3RIF A;  1I9B A;  4Z91 A;  4IL9 A;  5BP0 A;  4QH5 A;  4ZZB A;  3UU5 A;  4EZ1 A;  5KE4 A;  4QAA A;  2XNT A;  2YN6 A;  5SYO A;  5J5I A;  2XQ6 A;  4PIR A;  4COF A;  2XZ6 A;  2YOE A;  5LXB A;  3RI5 A;  5J5H A;  4ZK4 A;  3TLU A;  5HCM A;  4TNW A;  4ZR6 A;  2BG9 B;  3SH1 A;  3C79 A;  5LG3 A;  2BR7 A;  3RQU A;  5AFM B;  2XNU A;  1UW6 A;  4DBM A;  3PEO A;  2XQ4 A;  3LSV A;  2BG9 E;  2BYR A;  5BRX A;  2C9T A;  4LML A;  3UU4 A;  3WTL A;  4ZJT A;  3JAE A;  2VL0 A;  5HEH A;  3ZDH A;  4NPP A;  5AFH A;  5J0Z A;  5AFJ A;  4LMJ A;  2WNC A;  3EI0 A;  3UU8 A;  5JME A;  4UM1 A;  3TLV A;  4TWH A;  2UZ6 A;  4IRE A;  5CO5 A;  5J5G A;  3RIA A;  2QC1 B;  4X5T A;  4TWF A;  4A97 A;  2XYS A;  4LMK A;  3T4M A;  4F8H A;  4WV9 A;  3EAM A;  4IL4 A;  4UM3 S;  4QAB A;  4QAC A;  4HFC A;  2XQ5 A;  2W8G A;  4XK9 A;  3U8L A;  3ZDG A;  4XHE A;  5IUX A;  5L4E A;  3WTH A;  4ZRU A;  5HEO A;  3WTO A;  2BR8 A;  2Y7Y A;  4AFH A;  2PH9 A;  2XQ3 A;  5AFL A;  4QH4 A;  3JAF A;  3TLT A;  5L47 A;  4BQT A;  2ZJV A;  3EHZ A;  2WZY A;  4ZJS A;  3UQ7 A;  3PMZ A;  3TLS A;  3RQW A;  4UM3 A;  2XQ9 A;  2WN9 A;  4HFI A;  4D01 A;  2XQ8 A;  5AFN A;  3P50 A;  3WTI A;  3SQ6 A;  2W8F A;  3C84 A;  4AFG A;  2XYT A;  5HCJ A;  1UV6 A;  5BW2 A;  3IGQ A;  5AIN A;  5HEJ A; 
#chains in the Genus database with same CATH topology
 4ZZC A;  5HEG A;  2Y56 A;  2YKS A;  4FRR A;  2YME A;  3U8N A;  2X00 D;  3UQ4 A;  2BG9 A;  3WTM A;  5HEU A;  3GUA A;  3U8M A;  4ILA A;  5FJV A;  5L4H A;  3ZKR A;  5AFM A;  3WIP A;  2PGZ A;  3SIO A;  3UU6 A;  2BJ0 A;  2Y58 A;  5J5F A;  2YMD A;  2WNJ A;  3UUB A;  3RHW A;  4AFT A;  4A98 A;  3UU3 A;  2BYS A;  3SQ9 A;  4HFB A;  4HFH A;  4NZB A;  4UY2 A;  2ZJU A;  4ILC A;  4Z90 A;  3P4W A;  4HQP A;  3WTJ A;  5KZU A;  2BG9 C;  4BFQ A;  2BYP A;  4B5D A;  2XQ7 A;  3JAD A;  2X00 A;  3WTN A;  4ALX A;  2XQA A;  3WTK A;  4ZK1 A;  4HFE A;  2WNL A;  5TVC A;  3U8K A;  4QH1 A;  3U8J A;  3TLW A;  2Y57 A;  2Y54 A;  2XZ5 A;  2BYN A;  2BYQ A;  5CFB A;  4HFD A;  4TWD A;  4UM3 P;  4UXU A;  2XNV A;  4ILB A;  1UX2 A;  4TNV A;  5AFK A;  3RIF A;  1I9B A;  4Z91 A;  4IL9 A;  5BP0 A;  4QH5 A;  4ZZB A;  3UU5 A;  4EZ1 A;  5KE4 A;  4QAA A;  2XNT A;  2YN6 A;  5SYO A;  5J5I A;  2XQ6 A;  4PIR A;  4COF A;  2XZ6 A;  2YOE A;  5LXB A;  3RI5 A;  5J5H A;  4ZK4 A;  3TLU A;  5HCM A;  4TNW A;  4ZR6 A;  2BG9 B;  3SH1 A;  3C79 A;  5LG3 A;  2BR7 A;  3RQU A;  5AFM B;  2XNU A;  1UW6 A;  4DBM A;  3PEO A;  2XQ4 A;  3LSV A;  2BG9 E;  2BYR A;  5BRX A;  2C9T A;  4LML A;  3UU4 A;  3WTL A;  4ZJT A;  3JAE A;  2VL0 A;  5HEH A;  3ZDH A;  4NPP A;  5AFH A;  5J0Z A;  5AFJ A;  4LMJ A;  2WNC A;  3EI0 A;  3UU8 A;  5JME A;  4UM1 A;  3TLV A;  4TWH A;  2UZ6 A;  4IRE A;  5CO5 A;  5J5G A;  3RIA A;  2QC1 B;  4X5T A;  4TWF A;  4A97 A;  2XYS A;  4LMK A;  3T4M A;  4F8H A;  4WV9 A;  3EAM A;  4IL4 A;  4UM3 S;  4QAB A;  4QAC A;  4HFC A;  2XQ5 A;  2W8G A;  4XK9 A;  3U8L A;  3ZDG A;  4XHE A;  5IUX A;  5L4E A;  3WTH A;  4ZRU A;  5HEO A;  3WTO A;  2BR8 A;  2Y7Y A;  4AFH A;  2PH9 A;  2XQ3 A;  5AFL A;  4QH4 A;  3JAF A;  3TLT A;  5L47 A;  4BQT A;  2ZJV A;  3EHZ A;  2WZY A;  4ZJS A;  3UQ7 A;  3PMZ A;  3TLS A;  3RQW A;  4UM3 A;  2XQ9 A;  2WN9 A;  4HFI A;  4D01 A;  2XQ8 A;  5AFN A;  3P50 A;  3WTI A;  3SQ6 A;  2W8F A;  3C84 A;  4AFG A;  2XYT A;  5HCJ A;  1UV6 A;  5BW2 A;  3IGQ A;  5AIN A;  5HEJ A; 
#chains in the Genus database with same CATH homology
 4ZZC A;  5HEG A;  2Y56 A;  2YKS A;  4FRR A;  2YME A;  3U8N A;  2X00 D;  3UQ4 A;  2BG9 A;  3WTM A;  5HEU A;  3GUA A;  3U8M A;  4ILA A;  5FJV A;  5L4H A;  3ZKR A;  5AFM A;  3WIP A;  2PGZ A;  3SIO A;  3UU6 A;  2BJ0 A;  2Y58 A;  5J5F A;  2YMD A;  2WNJ A;  3UUB A;  3RHW A;  4AFT A;  4A98 A;  3UU3 A;  2BYS A;  3SQ9 A;  4HFB A;  4HFH A;  4NZB A;  4UY2 A;  2ZJU A;  4ILC A;  4Z90 A;  3P4W A;  4HQP A;  3WTJ A;  5KZU A;  2BG9 C;  4BFQ A;  2BYP A;  4B5D A;  2XQ7 A;  3JAD A;  2X00 A;  3WTN A;  4ALX A;  2XQA A;  3WTK A;  4ZK1 A;  4HFE A;  2WNL A;  5TVC A;  3U8K A;  4QH1 A;  3U8J A;  3TLW A;  2Y57 A;  2Y54 A;  2XZ5 A;  2BYN A;  2BYQ A;  5CFB A;  4HFD A;  4TWD A;  4UM3 P;  4UXU A;  2XNV A;  4ILB A;  1UX2 A;  4TNV A;  5AFK A;  3RIF A;  1I9B A;  4Z91 A;  4IL9 A;  5BP0 A;  4QH5 A;  4ZZB A;  3UU5 A;  4EZ1 A;  5KE4 A;  4QAA A;  2XNT A;  2YN6 A;  5SYO A;  5J5I A;  2XQ6 A;  4PIR A;  4COF A;  2XZ6 A;  2YOE A;  5LXB A;  3RI5 A;  5J5H A;  4ZK4 A;  3TLU A;  5HCM A;  4TNW A;  4ZR6 A;  2BG9 B;  3SH1 A;  3C79 A;  5LG3 A;  2BR7 A;  3RQU A;  5AFM B;  2XNU A;  1UW6 A;  4DBM A;  3PEO A;  2XQ4 A;  3LSV A;  2BG9 E;  2BYR A;  5BRX A;  2C9T A;  4LML A;  3UU4 A;  3WTL A;  4ZJT A;  3JAE A;  2VL0 A;  5HEH A;  3ZDH A;  4NPP A;  5AFH A;  5J0Z A;  5AFJ A;  4LMJ A;  2WNC A;  3EI0 A;  3UU8 A;  5JME A;  4UM1 A;  3TLV A;  4TWH A;  2UZ6 A;  4IRE A;  5CO5 A;  5J5G A;  3RIA A;  2QC1 B;  4X5T A;  4TWF A;  4A97 A;  2XYS A;  4LMK A;  3T4M A;  4F8H A;  4WV9 A;  3EAM A;  4IL4 A;  4UM3 S;  4QAB A;  4QAC A;  4HFC A;  2XQ5 A;  2W8G A;  4XK9 A;  3U8L A;  3ZDG A;  4XHE A;  5IUX A;  5L4E A;  3WTH A;  4ZRU A;  5HEO A;  3WTO A;  2BR8 A;  2Y7Y A;  4AFH A;  2PH9 A;  2XQ3 A;  5AFL A;  4QH4 A;  3JAF A;  3TLT A;  5L47 A;  4BQT A;  2ZJV A;  3EHZ A;  2WZY A;  4ZJS A;  3UQ7 A;  3PMZ A;  3TLS A;  3RQW A;  4UM3 A;  2XQ9 A;  2WN9 A;  4HFI A;  4D01 A;  2XQ8 A;  5AFN A;  3P50 A;  3WTI A;  3SQ6 A;  2W8F A;  3C84 A;  4AFG A;  2XYT A;  5HCJ A;  1UV6 A;  5BW2 A;  3IGQ A;  5AIN A;  5HEJ A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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4ZK4A

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations