4ZRUA

X-ray crystal structure of lymnaea stagnalis acetylcholine binding protein (ls-achbp) in complex with 3-[2-[(2s)-pyrrolidin-2-yl]ethynyl]pyridine (ti-5180)
Total Genus 49
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
49
sequence length
212
structure length
211
Chain Sequence
DYKDDDDKLDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLARVVSDGEVLYMPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTENSDDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKK
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Comparisons of Binding Affinities for Neuronal Nicotinic Receptors (NNRs) and AChBPs, and Structural Features of a High-Affinity, Non-selective NNR Ligand-AChBP Co-crystal Structure
rcsb
molecule tags Acetylcholine binding protein
source organism Lymnaea stagnalis
molecule keywords Acetylcholine-binding protein
total genus 49
structure length 211
sequence length 212
chains with identical sequence B, C, D, E, F, G, H, I, J
ec nomenclature
pdb deposition date 2015-05-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02931 Neur_chan_LBD Neurotransmitter-gated ion-channel ligand binding domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.170.10 Mainly Beta Distorted Sandwich Acetylcholine Binding Protein; Chain: A, Neurotransmitter-gated ion-channel ligand-binding domain 4zruA00
2PH9A 5JMEA 4QH4A 1UV6A 3WTMA 2XQ5A 2UZ6A 4IL4A 3UU8A 2WNCA 3UQ4A 3TLUA 3WTOA 2XQ9A 3WTHA 2XNTA 4DBMA 3U8JA 5J0ZA 5IUXA 4A98A 2YOEA 3UU3A 4QACA 5BW2A 2X00D 4FRRA 3RI5A 3SQ9A 3WTIA 4ILAA 3UU5A 1I9BA 3ZDHA 2XQ8A 3ZKRA 5AFKA 3UU4A 2XZ5A 3U8NA 2XQ3A 2XNUA 4HFEA 4QAAA 3RHWA 5AFHA 2WN9A 5L4HA 2ZJUA 3WTLA 5HCJA 4UXUA 3WTJA 2W8GA 3RQWA 5BRXA 2XZ6A 3U8MA 3WTNA 4XK9A 2Y56A 3RQUA 4EZ1A 4NZBA 2Y54A 5CFBA 5CO5A 4HFDA 3T4MA 4AFTA 3TLVA 2XNVA 4IREA 3GUAA 2BYNA 3LSVA 3RIFA 5HEUA 1UW6A 3EAMA 4UM3A 4ZZCA 5FJVA 2BG9C 3SH1A 5J5IA 4F8HA 3WTKA 3PMZA 4HQPA 3TLSA 3SQ6A 5AFNA 3JADA 2XQAA 4ZJTA 2BJ0A 2BG9E 2WNJA 2BR8A 3EI0A 5TVCA 4ZK4A 4UM3S 5J5HA 3C84A 5LG3A 3IGQA 2XQ4A 2QC1B 3C79A 2XQ6A 5HEGA 5AFMA 4TNWA 5HEOA 2BG9A 4HFHA 5AFMB 4D01A 4AFHA 4TWFA 3TLWA 2Y7YA 2XQ7A 2BG9B 3RIAA 5BP0A 4ZJSA 4Z91A 4X5TA 2XYSA 5HEHA 5KZUA 4UM1A 4A97A 4LMKA 2BYPA 4Z90A 4ZR6A 4ILBA 4TWHA 2W8FA 4LMJA 4ZRUA 3WIPA 4ZK1A 2YMEA 5HEJA 5KE4A 4HFIA 2BYSA 4PIRA 3JAFA 2BYRA 4ZZBA 4IL9A 4B5DA 2Y57A 2VL0A 5L47A 5L4EA 3U8KA 2C9TA 3P50A 5J5FA 3SIOA 5LXBA 3EHZA 3ZDGA 4COFA 3TLTA 2ZJVA 3JAEA 5J5GA 3U8LA 3P4WA 3PEOA 2BYQA 3UQ7A 5HCMA 4LMLA 4AFGA 3UU6A 2WNLA 4NPPA 4HFBA 4XHEA 1UX2A 2PGZA 2YKSA 5AFLA 4ILCA 2WZYA 4HFCA 4TNVA 4ALXA 5SYOA 4BFQA 2YMDA 5AFJA 2X00A 2XYTA 4QH1A 4WV9A 4UY2A 2Y58A 4QH5A 4UM3P 2YN6A 4TWDA 4BQTA 2BR7A 5AINA 4QABA 3UUBA
chains in the Genus database with same CATH superfamily
2PH9A 5JMEA 4QH4A 1UV6A 3WTMA 2XQ5A 2UZ6A 4IL4A 3UU8A 2WNCA 3UQ4A 3TLUA 3WTOA 2XQ9A 3WTHA 2XNTA 4DBMA 3U8JA 5J0ZA 5IUXA 4A98A 2YOEA 3UU3A 4QACA 5BW2A 2X00D 4FRRA 3RI5A 3SQ9A 3WTIA 4ILAA 3UU5A 1I9BA 3ZDHA 2XQ8A 3ZKRA 5AFKA 3UU4A 2XZ5A 3U8NA 2XQ3A 2XNUA 4HFEA 4QAAA 3RHWA 5AFHA 2WN9A 5L4HA 2ZJUA 3WTLA 5HCJA 4UXUA 3WTJA 2W8GA 3RQWA 5BRXA 2XZ6A 3U8MA 3WTNA 4XK9A 2Y56A 3RQUA 4EZ1A 4NZBA 2Y54A 5CFBA 5CO5A 4HFDA 3T4MA 4AFTA 3TLVA 2XNVA 4IREA 3GUAA 2BYNA 3LSVA 3RIFA 5HEUA 1UW6A 3EAMA 4UM3A 4ZZCA 5FJVA 2BG9C 3SH1A 5J5IA 4F8HA 3WTKA 3PMZA 4HQPA 3TLSA 3SQ6A 5AFNA 3JADA 2XQAA 4ZJTA 2BJ0A 2BG9E 2WNJA 2BR8A 3EI0A 5TVCA 4ZK4A 4UM3S 5J5HA 3C84A 5LG3A 3IGQA 2XQ4A 2QC1B 3C79A 2XQ6A 5HEGA 5AFMA 4TNWA 5HEOA 2BG9A 4HFHA 5AFMB 4D01A 4AFHA 4TWFA 3TLWA 2Y7YA 2XQ7A 2BG9B 3RIAA 5BP0A 4ZJSA 4Z91A 4X5TA 2XYSA 5HEHA 5KZUA 4UM1A 4A97A 4LMKA 2BYPA 4Z90A 4ZR6A 4ILBA 4TWHA 2W8FA 4LMJA 4ZRUA 3WIPA 4ZK1A 2YMEA 5HEJA 5KE4A 4HFIA 2BYSA 4PIRA 3JAFA 2BYRA 4ZZBA 4IL9A 4B5DA 2Y57A 2VL0A 5L47A 5L4EA 3U8KA 2C9TA 3P50A 5J5FA 3SIOA 5LXBA 3EHZA 3ZDGA 4COFA 3TLTA 2ZJVA 3JAEA 5J5GA 3U8LA 3P4WA 3PEOA 2BYQA 3UQ7A 5HCMA 4LMLA 4AFGA 3UU6A 2WNLA 4NPPA 4HFBA 4XHEA 1UX2A 2PGZA 2YKSA 5AFLA 4ILCA 2WZYA 4HFCA 4TNVA 4ALXA 5SYOA 4BFQA 2YMDA 5AFJA 2X00A 2XYTA 4QH1A 4WV9A 4UY2A 2Y58A 4QH5A 4UM3P 2YN6A 4TWDA 4BQTA 2BR7A 5AINA 4QABA 3UUBA
chains in the Genus database with same CATH topology
2PH9A 5JMEA 4QH4A 1UV6A 3WTMA 2XQ5A 2UZ6A 4IL4A 3UU8A 2WNCA 3UQ4A 3TLUA 3WTOA 2XQ9A 3WTHA 2XNTA 4DBMA 3U8JA 5J0ZA 5IUXA 4A98A 2YOEA 3UU3A 4QACA 5BW2A 2X00D 4FRRA 3RI5A 3SQ9A 3WTIA 4ILAA 3UU5A 1I9BA 3ZDHA 2XQ8A 3ZKRA 5AFKA 3UU4A 2XZ5A 3U8NA 2XQ3A 2XNUA 4HFEA 4QAAA 3RHWA 5AFHA 2WN9A 5L4HA 2ZJUA 3WTLA 5HCJA 4UXUA 3WTJA 2W8GA 3RQWA 5BRXA 2XZ6A 3U8MA 3WTNA 4XK9A 2Y56A 3RQUA 4EZ1A 4NZBA 2Y54A 5CFBA 5CO5A 4HFDA 3T4MA 4AFTA 3TLVA 2XNVA 4IREA 3GUAA 2BYNA 3LSVA 3RIFA 5HEUA 1UW6A 3EAMA 4UM3A 4ZZCA 5FJVA 2BG9C 3SH1A 5J5IA 4F8HA 3WTKA 3PMZA 4HQPA 3TLSA 3SQ6A 5AFNA 3JADA 2XQAA 4ZJTA 2BJ0A 2BG9E 2WNJA 2BR8A 3EI0A 5TVCA 4ZK4A 4UM3S 5J5HA 3C84A 5LG3A 3IGQA 2XQ4A 2QC1B 3C79A 2XQ6A 5HEGA 5AFMA 4TNWA 5HEOA 2BG9A 4HFHA 5AFMB 4D01A 4AFHA 4TWFA 3TLWA 2Y7YA 2XQ7A 2BG9B 3RIAA 5BP0A 4ZJSA 4Z91A 4X5TA 2XYSA 5HEHA 5KZUA 4UM1A 4A97A 4LMKA 2BYPA 4Z90A 4ZR6A 4ILBA 4TWHA 2W8FA 4LMJA 4ZRUA 3WIPA 4ZK1A 2YMEA 5HEJA 5KE4A 4HFIA 2BYSA 4PIRA 3JAFA 2BYRA 4ZZBA 4IL9A 4B5DA 2Y57A 2VL0A 5L47A 5L4EA 3U8KA 2C9TA 3P50A 5J5FA 3SIOA 5LXBA 3EHZA 3ZDGA 4COFA 3TLTA 2ZJVA 3JAEA 5J5GA 3U8LA 3P4WA 3PEOA 2BYQA 3UQ7A 5HCMA 4LMLA 4AFGA 3UU6A 2WNLA 4NPPA 4HFBA 4XHEA 1UX2A 2PGZA 2YKSA 5AFLA 4ILCA 2WZYA 4HFCA 4TNVA 4ALXA 5SYOA 4BFQA 2YMDA 5AFJA 2X00A 2XYTA 4QH1A 4WV9A 4UY2A 2Y58A 4QH5A 4UM3P 2YN6A 4TWDA 4BQTA 2BR7A 5AINA 4QABA 3UUBA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2PH9 A;  5JME A;  4QH4 A;  1UV6 A;  3WTM A;  2XQ5 A;  2UZ6 A;  4IL4 A;  3UU8 A;  2WNC A;  3UQ4 A;  3TLU A;  3WTO A;  2XQ9 A;  3WTH A;  2XNT A;  4DBM A;  3U8J A;  5J0Z A;  5IUX A;  4A98 A;  2YOE A;  3UU3 A;  4QAC A;  5BW2 A;  2X00 D;  4FRR A;  3RI5 A;  3SQ9 A;  3WTI A;  4ILA A;  3UU5 A;  1I9B A;  3ZDH A;  2XQ8 A;  3ZKR A;  5AFK A;  3UU4 A;  2XZ5 A;  3U8N A;  2XQ3 A;  2XNU A;  4HFE A;  4QAA A;  3RHW A;  5AFH A;  2WN9 A;  5L4H A;  2ZJU A;  3WTL A;  5HCJ A;  4UXU A;  3WTJ A;  2W8G A;  3RQW A;  5BRX A;  2XZ6 A;  3U8M A;  3WTN A;  4XK9 A;  2Y56 A;  3RQU A;  4EZ1 A;  4NZB A;  2Y54 A;  5CFB A;  5CO5 A;  4HFD A;  3T4M A;  4AFT A;  3TLV A;  2XNV A;  4IRE A;  3GUA A;  2BYN A;  3LSV A;  3RIF A;  5HEU A;  1UW6 A;  3EAM A;  4UM3 A;  4ZZC A;  5FJV A;  2BG9 C;  3SH1 A;  5J5I A;  4F8H A;  3WTK A;  3PMZ A;  4HQP A;  3TLS A;  3SQ6 A;  5AFN A;  3JAD A;  2XQA A;  4ZJT A;  2BJ0 A;  2BG9 E;  2WNJ A;  2BR8 A;  3EI0 A;  5TVC A;  4ZK4 A;  4UM3 S;  5J5H A;  3C84 A;  5LG3 A;  3IGQ A;  2XQ4 A;  2QC1 B;  3C79 A;  2XQ6 A;  5HEG A;  5AFM A;  4TNW A;  5HEO A;  2BG9 A;  4HFH A;  5AFM B;  4D01 A;  4AFH A;  4TWF A;  3TLW A;  2Y7Y A;  2XQ7 A;  2BG9 B;  3RIA A;  5BP0 A;  4ZJS A;  4Z91 A;  4X5T A;  2XYS A;  5HEH A;  5KZU A;  4UM1 A;  4A97 A;  4LMK A;  2BYP A;  4Z90 A;  4ZR6 A;  4ILB A;  4TWH A;  2W8F A;  4LMJ A;  4ZRU A;  3WIP A;  4ZK1 A;  2YME A;  5HEJ A;  5KE4 A;  4HFI A;  2BYS A;  4PIR A;  3JAF A;  2BYR A;  4ZZB A;  4IL9 A;  4B5D A;  2Y57 A;  2VL0 A;  5L47 A;  5L4E A;  3U8K A;  2C9T A;  3P50 A;  5J5F A;  3SIO A;  5LXB A;  3EHZ A;  3ZDG A;  4COF A;  3TLT A;  2ZJV A;  3JAE A;  5J5G A;  3U8L A;  3P4W A;  3PEO A;  2BYQ A;  3UQ7 A;  5HCM A;  4LML A;  4AFG A;  3UU6 A;  2WNL A;  4NPP A;  4HFB A;  4XHE A;  1UX2 A;  2PGZ A;  2YKS A;  5AFL A;  4ILC A;  2WZY A;  4HFC A;  4TNV A;  4ALX A;  5SYO A;  4BFQ A;  2YMD A;  5AFJ A;  2X00 A;  2XYT A;  4QH1 A;  4WV9 A;  4UY2 A;  2Y58 A;  4QH5 A;  4UM3 P;  2YN6 A;  4TWD A;  4BQT A;  2BR7 A;  5AIN A;  4QAB A;  3UUB A; 
#chains in the Genus database with same CATH topology
 2PH9 A;  5JME A;  4QH4 A;  1UV6 A;  3WTM A;  2XQ5 A;  2UZ6 A;  4IL4 A;  3UU8 A;  2WNC A;  3UQ4 A;  3TLU A;  3WTO A;  2XQ9 A;  3WTH A;  2XNT A;  4DBM A;  3U8J A;  5J0Z A;  5IUX A;  4A98 A;  2YOE A;  3UU3 A;  4QAC A;  5BW2 A;  2X00 D;  4FRR A;  3RI5 A;  3SQ9 A;  3WTI A;  4ILA A;  3UU5 A;  1I9B A;  3ZDH A;  2XQ8 A;  3ZKR A;  5AFK A;  3UU4 A;  2XZ5 A;  3U8N A;  2XQ3 A;  2XNU A;  4HFE A;  4QAA A;  3RHW A;  5AFH A;  2WN9 A;  5L4H A;  2ZJU A;  3WTL A;  5HCJ A;  4UXU A;  3WTJ A;  2W8G A;  3RQW A;  5BRX A;  2XZ6 A;  3U8M A;  3WTN A;  4XK9 A;  2Y56 A;  3RQU A;  4EZ1 A;  4NZB A;  2Y54 A;  5CFB A;  5CO5 A;  4HFD A;  3T4M A;  4AFT A;  3TLV A;  2XNV A;  4IRE A;  3GUA A;  2BYN A;  3LSV A;  3RIF A;  5HEU A;  1UW6 A;  3EAM A;  4UM3 A;  4ZZC A;  5FJV A;  2BG9 C;  3SH1 A;  5J5I A;  4F8H A;  3WTK A;  3PMZ A;  4HQP A;  3TLS A;  3SQ6 A;  5AFN A;  3JAD A;  2XQA A;  4ZJT A;  2BJ0 A;  2BG9 E;  2WNJ A;  2BR8 A;  3EI0 A;  5TVC A;  4ZK4 A;  4UM3 S;  5J5H A;  3C84 A;  5LG3 A;  3IGQ A;  2XQ4 A;  2QC1 B;  3C79 A;  2XQ6 A;  5HEG A;  5AFM A;  4TNW A;  5HEO A;  2BG9 A;  4HFH A;  5AFM B;  4D01 A;  4AFH A;  4TWF A;  3TLW A;  2Y7Y A;  2XQ7 A;  2BG9 B;  3RIA A;  5BP0 A;  4ZJS A;  4Z91 A;  4X5T A;  2XYS A;  5HEH A;  5KZU A;  4UM1 A;  4A97 A;  4LMK A;  2BYP A;  4Z90 A;  4ZR6 A;  4ILB A;  4TWH A;  2W8F A;  4LMJ A;  4ZRU A;  3WIP A;  4ZK1 A;  2YME A;  5HEJ A;  5KE4 A;  4HFI A;  2BYS A;  4PIR A;  3JAF A;  2BYR A;  4ZZB A;  4IL9 A;  4B5D A;  2Y57 A;  2VL0 A;  5L47 A;  5L4E A;  3U8K A;  2C9T A;  3P50 A;  5J5F A;  3SIO A;  5LXB A;  3EHZ A;  3ZDG A;  4COF A;  3TLT A;  2ZJV A;  3JAE A;  5J5G A;  3U8L A;  3P4W A;  3PEO A;  2BYQ A;  3UQ7 A;  5HCM A;  4LML A;  4AFG A;  3UU6 A;  2WNL A;  4NPP A;  4HFB A;  4XHE A;  1UX2 A;  2PGZ A;  2YKS A;  5AFL A;  4ILC A;  2WZY A;  4HFC A;  4TNV A;  4ALX A;  5SYO A;  4BFQ A;  2YMD A;  5AFJ A;  2X00 A;  2XYT A;  4QH1 A;  4WV9 A;  4UY2 A;  2Y58 A;  4QH5 A;  4UM3 P;  2YN6 A;  4TWD A;  4BQT A;  2BR7 A;  5AIN A;  4QAB A;  3UUB A; 
#chains in the Genus database with same CATH homology
 2PH9 A;  5JME A;  4QH4 A;  1UV6 A;  3WTM A;  2XQ5 A;  2UZ6 A;  4IL4 A;  3UU8 A;  2WNC A;  3UQ4 A;  3TLU A;  3WTO A;  2XQ9 A;  3WTH A;  2XNT A;  4DBM A;  3U8J A;  5J0Z A;  5IUX A;  4A98 A;  2YOE A;  3UU3 A;  4QAC A;  5BW2 A;  2X00 D;  4FRR A;  3RI5 A;  3SQ9 A;  3WTI A;  4ILA A;  3UU5 A;  1I9B A;  3ZDH A;  2XQ8 A;  3ZKR A;  5AFK A;  3UU4 A;  2XZ5 A;  3U8N A;  2XQ3 A;  2XNU A;  4HFE A;  4QAA A;  3RHW A;  5AFH A;  2WN9 A;  5L4H A;  2ZJU A;  3WTL A;  5HCJ A;  4UXU A;  3WTJ A;  2W8G A;  3RQW A;  5BRX A;  2XZ6 A;  3U8M A;  3WTN A;  4XK9 A;  2Y56 A;  3RQU A;  4EZ1 A;  4NZB A;  2Y54 A;  5CFB A;  5CO5 A;  4HFD A;  3T4M A;  4AFT A;  3TLV A;  2XNV A;  4IRE A;  3GUA A;  2BYN A;  3LSV A;  3RIF A;  5HEU A;  1UW6 A;  3EAM A;  4UM3 A;  4ZZC A;  5FJV A;  2BG9 C;  3SH1 A;  5J5I A;  4F8H A;  3WTK A;  3PMZ A;  4HQP A;  3TLS A;  3SQ6 A;  5AFN A;  3JAD A;  2XQA A;  4ZJT A;  2BJ0 A;  2BG9 E;  2WNJ A;  2BR8 A;  3EI0 A;  5TVC A;  4ZK4 A;  4UM3 S;  5J5H A;  3C84 A;  5LG3 A;  3IGQ A;  2XQ4 A;  2QC1 B;  3C79 A;  2XQ6 A;  5HEG A;  5AFM A;  4TNW A;  5HEO A;  2BG9 A;  4HFH A;  5AFM B;  4D01 A;  4AFH A;  4TWF A;  3TLW A;  2Y7Y A;  2XQ7 A;  2BG9 B;  3RIA A;  5BP0 A;  4ZJS A;  4Z91 A;  4X5T A;  2XYS A;  5HEH A;  5KZU A;  4UM1 A;  4A97 A;  4LMK A;  2BYP A;  4Z90 A;  4ZR6 A;  4ILB A;  4TWH A;  2W8F A;  4LMJ A;  4ZRU A;  3WIP A;  4ZK1 A;  2YME A;  5HEJ A;  5KE4 A;  4HFI A;  2BYS A;  4PIR A;  3JAF A;  2BYR A;  4ZZB A;  4IL9 A;  4B5D A;  2Y57 A;  2VL0 A;  5L47 A;  5L4E A;  3U8K A;  2C9T A;  3P50 A;  5J5F A;  3SIO A;  5LXB A;  3EHZ A;  3ZDG A;  4COF A;  3TLT A;  2ZJV A;  3JAE A;  5J5G A;  3U8L A;  3P4W A;  3PEO A;  2BYQ A;  3UQ7 A;  5HCM A;  4LML A;  4AFG A;  3UU6 A;  2WNL A;  4NPP A;  4HFB A;  4XHE A;  1UX2 A;  2PGZ A;  2YKS A;  5AFL A;  4ILC A;  2WZY A;  4HFC A;  4TNV A;  4ALX A;  5SYO A;  4BFQ A;  2YMD A;  5AFJ A;  2X00 A;  2XYT A;  4QH1 A;  4WV9 A;  4UY2 A;  2Y58 A;  4QH5 A;  4UM3 P;  2YN6 A;  4TWD A;  4BQT A;  2BR7 A;  5AIN A;  4QAB A;  3UUB A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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