4HQPA

Alpha7 nicotinic receptor chimera and its complex with alpha bungarotoxin
Total Genus 41
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
41
sequence length
202
structure length
202
Chain Sequence
QRKLYKELVKNYNPDVIPTQRDRPVTVYFSLSLLQIMDVDEKNQVVDVVFWLQMSWTDHYLQWNVSEYPGVKQVSVPISSLWVPDLAAYNAISKPEVLTPQLALVNSSGHVQYLPSIRQRFSCDVSGVDTESGATCKLKFGSWTHHSRELDLQMQEADISGYIPYSRFELVGVTQKRSERFYECCKEPYPDVTFTVTFRKKG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural principles for Alpha-neurotoxin binding to and selectivity among nicotinic receptors
rcsb
molecule tags Protein binding
source organism Homo sapiens, lymnaea stagnalis
molecule keywords Alpha7 nicotinic receptor chimera
total genus 41
structure length 202
sequence length 202
chains with identical sequence B, C, D, E
ec nomenclature
pdb deposition date 2012-10-25
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.170.10 Mainly Beta Distorted Sandwich Acetylcholine Binding Protein; Chain: A, Neurotransmitter-gated ion-channel ligand-binding domain 4hqpA00
5JMEA 5SYOA 5AFJA 3SQ9A 4FRRA 3TLTA 3JAFA 3RIAA 3ZKRA 2XYTA 5HEJA 3RHWA 4TWFA 3PMZA 5J5HA 2BG9B 5HCMA 5HCJA 4LMJA 5AFLA 4ZJTA 4HFBA 5L47A 4UM3P 2XQ8A 4TNWA 3RIFA 4ZK4A 2XQ4A 3ZDGA 5AFMA 3U8MA 2BG9E 3UU4A 4BQTA 3WTJA 4AFHA 4BFQA 3U8KA 3TLWA 3EI0A 4XHEA 3RQWA 5BW2A 4ILBA 3C84A 3WTIA 2ZJVA 2C9TA 3EAMA 2YN6A 2ZJUA 2XQ7A 2VL0A 4ILAA 2WNCA 2XNTA 4HFHA 4IREA 5AFKA 2WNLA 2Y56A 5HEOA 5J5IA 3UQ7A 2Y57A 3WTOA 2BR7A 4ZK1A 2YOEA 3UU8A 4UXUA 2WNJA 2X00D 5AFNA 3C79A 5CO5A 3SQ6A 3WTMA 2XNUA 4XK9A 5BP0A 5J5GA 3WTNA 4QH4A 3WTLA 2XQ6A 3WIPA 3EHZA 5J5FA 4HFIA 3WTHA 4TWDA 2W8FA 3UU5A 4AFGA 3UUBA 4HFCA 4ILCA 3U8JA 2XQAA 3RQUA 4UY2A 3JADA 4QAAA 4NZBA 2WN9A 4AFTA 4B5DA 5AFHA 5J0ZA 4ZJSA 5LG3A 2X00A 3P50A 2BR8A 4ZRUA 4HFDA 2BYSA 4COFA 5AFMB 4IL4A 5KZUA 2BG9A 4UM3A 4D01A 2W8GA 2XQ9A 2Y7YA 3U8LA 2XYSA 4QACA 3WTKA 5KE4A 2BYPA 2BYQA 5IUXA 4TWHA 4WV9A 3SH1A 5AINA 2BJ0A 4ZZCA 3JAEA 4ZR6A 4LMKA 4DBMA 4A97A 4IL9A 2BYRA 2XNVA 3T4MA 2BG9C 4F8HA 5CFBA 2PH9A 5L4EA 2XQ3A 3LSVA 1UV6A 4EZ1A 2PGZA 3TLVA 3RI5A 4QH5A 5BRXA 4LMLA 4TNVA 4ZZBA 5L4HA 3UQ4A 5LXBA 4A98A 1UX2A 4QABA 2YMEA 3IGQA 4HQPA 4UM1A 3TLSA 2QC1B 5HEUA 3UU3A 4NPPA 2YKSA 2Y58A 2YMDA 2XQ5A 3UU6A 3P4WA 4X5TA 3PEOA 5HEHA 2XZ5A 4QH1A 5FJVA 3GUAA 3TLUA 4Z90A 5TVCA 2XZ6A 3ZDHA 3U8NA 4ALXA 4UM3S 3SIOA 2Y54A 4HFEA 2WZYA 1UW6A 4Z91A 4PIRA 2BYNA 1I9BA 2UZ6A 5HEGA
chains in the Genus database with same CATH superfamily
5JMEA 5SYOA 5AFJA 3SQ9A 4FRRA 3TLTA 3JAFA 3RIAA 3ZKRA 2XYTA 5HEJA 3RHWA 4TWFA 3PMZA 5J5HA 2BG9B 5HCMA 5HCJA 4LMJA 5AFLA 4ZJTA 4HFBA 5L47A 4UM3P 2XQ8A 4TNWA 3RIFA 4ZK4A 2XQ4A 3ZDGA 5AFMA 3U8MA 2BG9E 3UU4A 4BQTA 3WTJA 4AFHA 4BFQA 3U8KA 3TLWA 3EI0A 4XHEA 3RQWA 5BW2A 4ILBA 3C84A 3WTIA 2ZJVA 2C9TA 3EAMA 2YN6A 2ZJUA 2XQ7A 2VL0A 4ILAA 2WNCA 2XNTA 4HFHA 4IREA 5AFKA 2WNLA 2Y56A 5HEOA 5J5IA 3UQ7A 2Y57A 3WTOA 2BR7A 4ZK1A 2YOEA 3UU8A 4UXUA 2WNJA 2X00D 5AFNA 3C79A 5CO5A 3SQ6A 3WTMA 2XNUA 4XK9A 5BP0A 5J5GA 3WTNA 4QH4A 3WTLA 2XQ6A 3WIPA 3EHZA 5J5FA 4HFIA 3WTHA 4TWDA 2W8FA 3UU5A 4AFGA 3UUBA 4HFCA 4ILCA 3U8JA 2XQAA 3RQUA 4UY2A 3JADA 4QAAA 4NZBA 2WN9A 4AFTA 4B5DA 5AFHA 5J0ZA 4ZJSA 5LG3A 2X00A 3P50A 2BR8A 4ZRUA 4HFDA 2BYSA 4COFA 5AFMB 4IL4A 5KZUA 2BG9A 4UM3A 4D01A 2W8GA 2XQ9A 2Y7YA 3U8LA 2XYSA 4QACA 3WTKA 5KE4A 2BYPA 2BYQA 5IUXA 4TWHA 4WV9A 3SH1A 5AINA 2BJ0A 4ZZCA 3JAEA 4ZR6A 4LMKA 4DBMA 4A97A 4IL9A 2BYRA 2XNVA 3T4MA 2BG9C 4F8HA 5CFBA 2PH9A 5L4EA 2XQ3A 3LSVA 1UV6A 4EZ1A 2PGZA 3TLVA 3RI5A 4QH5A 5BRXA 4LMLA 4TNVA 4ZZBA 5L4HA 3UQ4A 5LXBA 4A98A 1UX2A 4QABA 2YMEA 3IGQA 4HQPA 4UM1A 3TLSA 2QC1B 5HEUA 3UU3A 4NPPA 2YKSA 2Y58A 2YMDA 2XQ5A 3UU6A 3P4WA 4X5TA 3PEOA 5HEHA 2XZ5A 4QH1A 5FJVA 3GUAA 3TLUA 4Z90A 5TVCA 2XZ6A 3ZDHA 3U8NA 4ALXA 4UM3S 3SIOA 2Y54A 4HFEA 2WZYA 1UW6A 4Z91A 4PIRA 2BYNA 1I9BA 2UZ6A 5HEGA
chains in the Genus database with same CATH topology
5JMEA 5SYOA 5AFJA 3SQ9A 4FRRA 3TLTA 3JAFA 3RIAA 3ZKRA 2XYTA 5HEJA 3RHWA 4TWFA 3PMZA 5J5HA 2BG9B 5HCMA 5HCJA 4LMJA 5AFLA 4ZJTA 4HFBA 5L47A 4UM3P 2XQ8A 4TNWA 3RIFA 4ZK4A 2XQ4A 3ZDGA 5AFMA 3U8MA 2BG9E 3UU4A 4BQTA 3WTJA 4AFHA 4BFQA 3U8KA 3TLWA 3EI0A 4XHEA 3RQWA 5BW2A 4ILBA 3C84A 3WTIA 2ZJVA 2C9TA 3EAMA 2YN6A 2ZJUA 2XQ7A 2VL0A 4ILAA 2WNCA 2XNTA 4HFHA 4IREA 5AFKA 2WNLA 2Y56A 5HEOA 5J5IA 3UQ7A 2Y57A 3WTOA 2BR7A 4ZK1A 2YOEA 3UU8A 4UXUA 2WNJA 2X00D 5AFNA 3C79A 5CO5A 3SQ6A 3WTMA 2XNUA 4XK9A 5BP0A 5J5GA 3WTNA 4QH4A 3WTLA 2XQ6A 3WIPA 3EHZA 5J5FA 4HFIA 3WTHA 4TWDA 2W8FA 3UU5A 4AFGA 3UUBA 4HFCA 4ILCA 3U8JA 2XQAA 3RQUA 4UY2A 3JADA 4QAAA 4NZBA 2WN9A 4AFTA 4B5DA 5AFHA 5J0ZA 4ZJSA 5LG3A 2X00A 3P50A 2BR8A 4ZRUA 4HFDA 2BYSA 4COFA 5AFMB 4IL4A 5KZUA 2BG9A 4UM3A 4D01A 2W8GA 2XQ9A 2Y7YA 3U8LA 2XYSA 4QACA 3WTKA 5KE4A 2BYPA 2BYQA 5IUXA 4TWHA 4WV9A 3SH1A 5AINA 2BJ0A 4ZZCA 3JAEA 4ZR6A 4LMKA 4DBMA 4A97A 4IL9A 2BYRA 2XNVA 3T4MA 2BG9C 4F8HA 5CFBA 2PH9A 5L4EA 2XQ3A 3LSVA 1UV6A 4EZ1A 2PGZA 3TLVA 3RI5A 4QH5A 5BRXA 4LMLA 4TNVA 4ZZBA 5L4HA 3UQ4A 5LXBA 4A98A 1UX2A 4QABA 2YMEA 3IGQA 4HQPA 4UM1A 3TLSA 2QC1B 5HEUA 3UU3A 4NPPA 2YKSA 2Y58A 2YMDA 2XQ5A 3UU6A 3P4WA 4X5TA 3PEOA 5HEHA 2XZ5A 4QH1A 5FJVA 3GUAA 3TLUA 4Z90A 5TVCA 2XZ6A 3ZDHA 3U8NA 4ALXA 4UM3S 3SIOA 2Y54A 4HFEA 2WZYA 1UW6A 4Z91A 4PIRA 2BYNA 1I9BA 2UZ6A 5HEGA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5JME A;  5SYO A;  5AFJ A;  3SQ9 A;  4FRR A;  3TLT A;  3JAF A;  3RIA A;  3ZKR A;  2XYT A;  5HEJ A;  3RHW A;  4TWF A;  3PMZ A;  5J5H A;  2BG9 B;  5HCM A;  5HCJ A;  4LMJ A;  5AFL A;  4ZJT A;  4HFB A;  5L47 A;  4UM3 P;  2XQ8 A;  4TNW A;  3RIF A;  4ZK4 A;  2XQ4 A;  3ZDG A;  5AFM A;  3U8M A;  2BG9 E;  3UU4 A;  4BQT A;  3WTJ A;  4AFH A;  4BFQ A;  3U8K A;  3TLW A;  3EI0 A;  4XHE A;  3RQW A;  5BW2 A;  4ILB A;  3C84 A;  3WTI A;  2ZJV A;  2C9T A;  3EAM A;  2YN6 A;  2ZJU A;  2XQ7 A;  2VL0 A;  4ILA A;  2WNC A;  2XNT A;  4HFH A;  4IRE A;  5AFK A;  2WNL A;  2Y56 A;  5HEO A;  5J5I A;  3UQ7 A;  2Y57 A;  3WTO A;  2BR7 A;  4ZK1 A;  2YOE A;  3UU8 A;  4UXU A;  2WNJ A;  2X00 D;  5AFN A;  3C79 A;  5CO5 A;  3SQ6 A;  3WTM A;  2XNU A;  4XK9 A;  5BP0 A;  5J5G A;  3WTN A;  4QH4 A;  3WTL A;  2XQ6 A;  3WIP A;  3EHZ A;  5J5F A;  4HFI A;  3WTH A;  4TWD A;  2W8F A;  3UU5 A;  4AFG A;  3UUB A;  4HFC A;  4ILC A;  3U8J A;  2XQA A;  3RQU A;  4UY2 A;  3JAD A;  4QAA A;  4NZB A;  2WN9 A;  4AFT A;  4B5D A;  5AFH A;  5J0Z A;  4ZJS A;  5LG3 A;  2X00 A;  3P50 A;  2BR8 A;  4ZRU A;  4HFD A;  2BYS A;  4COF A;  5AFM B;  4IL4 A;  5KZU A;  2BG9 A;  4UM3 A;  4D01 A;  2W8G A;  2XQ9 A;  2Y7Y A;  3U8L A;  2XYS A;  4QAC A;  3WTK A;  5KE4 A;  2BYP A;  2BYQ A;  5IUX A;  4TWH A;  4WV9 A;  3SH1 A;  5AIN A;  2BJ0 A;  4ZZC A;  3JAE A;  4ZR6 A;  4LMK A;  4DBM A;  4A97 A;  4IL9 A;  2BYR A;  2XNV A;  3T4M A;  2BG9 C;  4F8H A;  5CFB A;  2PH9 A;  5L4E A;  2XQ3 A;  3LSV A;  1UV6 A;  4EZ1 A;  2PGZ A;  3TLV A;  3RI5 A;  4QH5 A;  5BRX A;  4LML A;  4TNV A;  4ZZB A;  5L4H A;  3UQ4 A;  5LXB A;  4A98 A;  1UX2 A;  4QAB A;  2YME A;  3IGQ A;  4HQP A;  4UM1 A;  3TLS A;  2QC1 B;  5HEU A;  3UU3 A;  4NPP A;  2YKS A;  2Y58 A;  2YMD A;  2XQ5 A;  3UU6 A;  3P4W A;  4X5T A;  3PEO A;  5HEH A;  2XZ5 A;  4QH1 A;  5FJV A;  3GUA A;  3TLU A;  4Z90 A;  5TVC A;  2XZ6 A;  3ZDH A;  3U8N A;  4ALX A;  4UM3 S;  3SIO A;  2Y54 A;  4HFE A;  2WZY A;  1UW6 A;  4Z91 A;  4PIR A;  2BYN A;  1I9B A;  2UZ6 A;  5HEG A; 
#chains in the Genus database with same CATH topology
 5JME A;  5SYO A;  5AFJ A;  3SQ9 A;  4FRR A;  3TLT A;  3JAF A;  3RIA A;  3ZKR A;  2XYT A;  5HEJ A;  3RHW A;  4TWF A;  3PMZ A;  5J5H A;  2BG9 B;  5HCM A;  5HCJ A;  4LMJ A;  5AFL A;  4ZJT A;  4HFB A;  5L47 A;  4UM3 P;  2XQ8 A;  4TNW A;  3RIF A;  4ZK4 A;  2XQ4 A;  3ZDG A;  5AFM A;  3U8M A;  2BG9 E;  3UU4 A;  4BQT A;  3WTJ A;  4AFH A;  4BFQ A;  3U8K A;  3TLW A;  3EI0 A;  4XHE A;  3RQW A;  5BW2 A;  4ILB A;  3C84 A;  3WTI A;  2ZJV A;  2C9T A;  3EAM A;  2YN6 A;  2ZJU A;  2XQ7 A;  2VL0 A;  4ILA A;  2WNC A;  2XNT A;  4HFH A;  4IRE A;  5AFK A;  2WNL A;  2Y56 A;  5HEO A;  5J5I A;  3UQ7 A;  2Y57 A;  3WTO A;  2BR7 A;  4ZK1 A;  2YOE A;  3UU8 A;  4UXU A;  2WNJ A;  2X00 D;  5AFN A;  3C79 A;  5CO5 A;  3SQ6 A;  3WTM A;  2XNU A;  4XK9 A;  5BP0 A;  5J5G A;  3WTN A;  4QH4 A;  3WTL A;  2XQ6 A;  3WIP A;  3EHZ A;  5J5F A;  4HFI A;  3WTH A;  4TWD A;  2W8F A;  3UU5 A;  4AFG A;  3UUB A;  4HFC A;  4ILC A;  3U8J A;  2XQA A;  3RQU A;  4UY2 A;  3JAD A;  4QAA A;  4NZB A;  2WN9 A;  4AFT A;  4B5D A;  5AFH A;  5J0Z A;  4ZJS A;  5LG3 A;  2X00 A;  3P50 A;  2BR8 A;  4ZRU A;  4HFD A;  2BYS A;  4COF A;  5AFM B;  4IL4 A;  5KZU A;  2BG9 A;  4UM3 A;  4D01 A;  2W8G A;  2XQ9 A;  2Y7Y A;  3U8L A;  2XYS A;  4QAC A;  3WTK A;  5KE4 A;  2BYP A;  2BYQ A;  5IUX A;  4TWH A;  4WV9 A;  3SH1 A;  5AIN A;  2BJ0 A;  4ZZC A;  3JAE A;  4ZR6 A;  4LMK A;  4DBM A;  4A97 A;  4IL9 A;  2BYR A;  2XNV A;  3T4M A;  2BG9 C;  4F8H A;  5CFB A;  2PH9 A;  5L4E A;  2XQ3 A;  3LSV A;  1UV6 A;  4EZ1 A;  2PGZ A;  3TLV A;  3RI5 A;  4QH5 A;  5BRX A;  4LML A;  4TNV A;  4ZZB A;  5L4H A;  3UQ4 A;  5LXB A;  4A98 A;  1UX2 A;  4QAB A;  2YME A;  3IGQ A;  4HQP A;  4UM1 A;  3TLS A;  2QC1 B;  5HEU A;  3UU3 A;  4NPP A;  2YKS A;  2Y58 A;  2YMD A;  2XQ5 A;  3UU6 A;  3P4W A;  4X5T A;  3PEO A;  5HEH A;  2XZ5 A;  4QH1 A;  5FJV A;  3GUA A;  3TLU A;  4Z90 A;  5TVC A;  2XZ6 A;  3ZDH A;  3U8N A;  4ALX A;  4UM3 S;  3SIO A;  2Y54 A;  4HFE A;  2WZY A;  1UW6 A;  4Z91 A;  4PIR A;  2BYN A;  1I9B A;  2UZ6 A;  5HEG A; 
#chains in the Genus database with same CATH homology
 5JME A;  5SYO A;  5AFJ A;  3SQ9 A;  4FRR A;  3TLT A;  3JAF A;  3RIA A;  3ZKR A;  2XYT A;  5HEJ A;  3RHW A;  4TWF A;  3PMZ A;  5J5H A;  2BG9 B;  5HCM A;  5HCJ A;  4LMJ A;  5AFL A;  4ZJT A;  4HFB A;  5L47 A;  4UM3 P;  2XQ8 A;  4TNW A;  3RIF A;  4ZK4 A;  2XQ4 A;  3ZDG A;  5AFM A;  3U8M A;  2BG9 E;  3UU4 A;  4BQT A;  3WTJ A;  4AFH A;  4BFQ A;  3U8K A;  3TLW A;  3EI0 A;  4XHE A;  3RQW A;  5BW2 A;  4ILB A;  3C84 A;  3WTI A;  2ZJV A;  2C9T A;  3EAM A;  2YN6 A;  2ZJU A;  2XQ7 A;  2VL0 A;  4ILA A;  2WNC A;  2XNT A;  4HFH A;  4IRE A;  5AFK A;  2WNL A;  2Y56 A;  5HEO A;  5J5I A;  3UQ7 A;  2Y57 A;  3WTO A;  2BR7 A;  4ZK1 A;  2YOE A;  3UU8 A;  4UXU A;  2WNJ A;  2X00 D;  5AFN A;  3C79 A;  5CO5 A;  3SQ6 A;  3WTM A;  2XNU A;  4XK9 A;  5BP0 A;  5J5G A;  3WTN A;  4QH4 A;  3WTL A;  2XQ6 A;  3WIP A;  3EHZ A;  5J5F A;  4HFI A;  3WTH A;  4TWD A;  2W8F A;  3UU5 A;  4AFG A;  3UUB A;  4HFC A;  4ILC A;  3U8J A;  2XQA A;  3RQU A;  4UY2 A;  3JAD A;  4QAA A;  4NZB A;  2WN9 A;  4AFT A;  4B5D A;  5AFH A;  5J0Z A;  4ZJS A;  5LG3 A;  2X00 A;  3P50 A;  2BR8 A;  4ZRU A;  4HFD A;  2BYS A;  4COF A;  5AFM B;  4IL4 A;  5KZU A;  2BG9 A;  4UM3 A;  4D01 A;  2W8G A;  2XQ9 A;  2Y7Y A;  3U8L A;  2XYS A;  4QAC A;  3WTK A;  5KE4 A;  2BYP A;  2BYQ A;  5IUX A;  4TWH A;  4WV9 A;  3SH1 A;  5AIN A;  2BJ0 A;  4ZZC A;  3JAE A;  4ZR6 A;  4LMK A;  4DBM A;  4A97 A;  4IL9 A;  2BYR A;  2XNV A;  3T4M A;  2BG9 C;  4F8H A;  5CFB A;  2PH9 A;  5L4E A;  2XQ3 A;  3LSV A;  1UV6 A;  4EZ1 A;  2PGZ A;  3TLV A;  3RI5 A;  4QH5 A;  5BRX A;  4LML A;  4TNV A;  4ZZB A;  5L4H A;  3UQ4 A;  5LXB A;  4A98 A;  1UX2 A;  4QAB A;  2YME A;  3IGQ A;  4HQP A;  4UM1 A;  3TLS A;  2QC1 B;  5HEU A;  3UU3 A;  4NPP A;  2YKS A;  2Y58 A;  2YMD A;  2XQ5 A;  3UU6 A;  3P4W A;  4X5T A;  3PEO A;  5HEH A;  2XZ5 A;  4QH1 A;  5FJV A;  3GUA A;  3TLU A;  4Z90 A;  5TVC A;  2XZ6 A;  3ZDH A;  3U8N A;  4ALX A;  4UM3 S;  3SIO A;  2Y54 A;  4HFE A;  2WZY A;  1UW6 A;  4Z91 A;  4PIR A;  2BYN A;  1I9B A;  2UZ6 A;  5HEG A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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