5AFJA

Alpha7-achbp in complex with lobeline and fragment 1
Total Genus 47
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
47
sequence length
204
structure length
204
Chain Sequence
EFQRKLYKELVKNYNPDVIPTQRDRPVTVYFSLSLLQIMDVDEKNQVVDVVFWLQMSWTDHYLQWNVSEYPGVKQVSVPISSLWVPDLAAYNAISKPEVLTPQLALVNSSGHVQYLPSIRQRFSCDVSGVDTESGATCKLKFGSWTHHSRELDLQMQEADISGYIPYSRFELVGVTQKRSERFYECCKEPYPDVTFTVTFRKKG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Molecular Blueprint of Allosteric Binding Sites in a Homologue of the Agonist-Binding Domain of the Alpha7 Nicotinic Acetylcholine Receptor.
pubmed doi rcsb
molecule tags Transport protein
source organism Homo sapiens
molecule keywords ACETYLCHOLINE-BINDING PROTEIN, NEURONAL ACETYLCHOLINE RECEPT
total genus 47
structure length 204
sequence length 204
chains with identical sequence B, C, D, E
ec nomenclature
pdb deposition date 2015-01-22
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.170.10 Mainly Beta Distorted Sandwich Acetylcholine Binding Protein; Chain: A, Neurotransmitter-gated ion-channel ligand-binding domain 5afjA00
4ILBA 3UQ4A 4COFA 3ZDGA 5AFNA 2BR7A 3LSVA 3RIFA 4ZZCA 5J0ZA 2BR8A 2XQ7A 3JAFA 4B5DA 3EI0A 1UV6A 3EAMA 3EHZA 3SQ6A 4HFBA 3RQWA 5IUXA 3TLTA 4ILCA 2XZ6A 4IREA 4ILAA 4FRRA 5AFMB 4X5TA 5J5GA 4QH5A 4LMLA 2W8FA 2BJ0A 4IL9A 2BG9B 2WNCA 3JAEA 2ZJUA 4XHEA 4QABA 4ZZBA 2Y57A 3UU6A 4F8HA 2YKSA 5AFLA 2YMEA 2XQ8A 4AFGA 4TWDA 4WV9A 4ALXA 5KZUA 4ZRUA 2XQAA 4IL4A 4HFDA 2C9TA 2XQ5A 3C84A 4QACA 4A97A 4HFEA 5CO5A 2UZ6A 3ZKRA 4UXUA 3SIOA 3WTMA 2WN9A 3IGQA 2XYTA 3SQ9A 3WTJA 4Z90A 5HEHA 5AINA 4PIRA 3UU8A 2XQ4A 4TWHA 5KE4A 2X00D 4ZK4A 5AFKA 2XYSA 3UU4A 2W8GA 3PMZA 2BYRA 4ZR6A 5LG3A 4LMKA 1UW6A 5L4EA 5HEUA 3PEOA 3WTLA 2Y56A 2Y7YA 5HEJA 2Y58A 3WTNA 5AFHA 3WTIA 3SH1A 5J5IA 5AFMA 4BFQA 3UQ7A 3U8JA 2BG9E 2PGZA 2BYPA 2BG9A 5BRXA 4QAAA 5JMEA 4ZK1A 3WTOA 4Z91A 2XQ9A 3U8NA 2BYSA 3WTKA 3WTHA 4NZBA 2X00A 4ZJTA 4AFHA 3ZDHA 3WIPA 5HEOA 4QH1A 2BYQA 3UUBA 4HFHA 4D01A 2BG9C 5HEGA 3TLUA 3TLVA 4TWFA 3TLWA 3RQUA 4NPPA 3RHWA 5LXBA 4TNWA 4UM1A 2XNTA 3GUAA 4QH4A 3U8MA 2WNLA 5L47A 2WNJA 5J5HA 5HCJA 2XZ5A 5L4HA 4BQTA 2QC1B 4EZ1A 5CFBA 3C79A 3U8LA 2WZYA 2Y54A 3T4MA 2XNVA 4AFTA 5BW2A 5AFJA 5SYOA 1I9BA 3JADA 1UX2A 4XK9A 3UU3A 4LMJA 4DBMA 3UU5A 2VL0A 4ZJSA 3P4WA 2YN6A 4TNVA 2BYNA 2YOEA 2XQ6A 4HQPA 5BP0A 5HCMA 4UM3A 4UM3P 3RI5A 4HFCA 4UY2A 2XNUA 2YMDA 3RIAA 5J5FA 4HFIA 2PH9A 5TVCA 4UM3S 2XQ3A 2ZJVA 4A98A 3U8KA 3P50A 5FJVA 3TLSA
chains in the Genus database with same CATH superfamily
4ILBA 3UQ4A 4COFA 3ZDGA 5AFNA 2BR7A 3LSVA 3RIFA 4ZZCA 5J0ZA 2BR8A 2XQ7A 3JAFA 4B5DA 3EI0A 1UV6A 3EAMA 3EHZA 3SQ6A 4HFBA 3RQWA 5IUXA 3TLTA 4ILCA 2XZ6A 4IREA 4ILAA 4FRRA 5AFMB 4X5TA 5J5GA 4QH5A 4LMLA 2W8FA 2BJ0A 4IL9A 2BG9B 2WNCA 3JAEA 2ZJUA 4XHEA 4QABA 4ZZBA 2Y57A 3UU6A 4F8HA 2YKSA 5AFLA 2YMEA 2XQ8A 4AFGA 4TWDA 4WV9A 4ALXA 5KZUA 4ZRUA 2XQAA 4IL4A 4HFDA 2C9TA 2XQ5A 3C84A 4QACA 4A97A 4HFEA 5CO5A 2UZ6A 3ZKRA 4UXUA 3SIOA 3WTMA 2WN9A 3IGQA 2XYTA 3SQ9A 3WTJA 4Z90A 5HEHA 5AINA 4PIRA 3UU8A 2XQ4A 4TWHA 5KE4A 2X00D 4ZK4A 5AFKA 2XYSA 3UU4A 2W8GA 3PMZA 2BYRA 4ZR6A 5LG3A 4LMKA 1UW6A 5L4EA 5HEUA 3PEOA 3WTLA 2Y56A 2Y7YA 5HEJA 2Y58A 3WTNA 5AFHA 3WTIA 3SH1A 5J5IA 5AFMA 4BFQA 3UQ7A 3U8JA 2BG9E 2PGZA 2BYPA 2BG9A 5BRXA 4QAAA 5JMEA 4ZK1A 3WTOA 4Z91A 2XQ9A 3U8NA 2BYSA 3WTKA 3WTHA 4NZBA 2X00A 4ZJTA 4AFHA 3ZDHA 3WIPA 5HEOA 4QH1A 2BYQA 3UUBA 4HFHA 4D01A 2BG9C 5HEGA 3TLUA 3TLVA 4TWFA 3TLWA 3RQUA 4NPPA 3RHWA 5LXBA 4TNWA 4UM1A 2XNTA 3GUAA 4QH4A 3U8MA 2WNLA 5L47A 2WNJA 5J5HA 5HCJA 2XZ5A 5L4HA 4BQTA 2QC1B 4EZ1A 5CFBA 3C79A 3U8LA 2WZYA 2Y54A 3T4MA 2XNVA 4AFTA 5BW2A 5AFJA 5SYOA 1I9BA 3JADA 1UX2A 4XK9A 3UU3A 4LMJA 4DBMA 3UU5A 2VL0A 4ZJSA 3P4WA 2YN6A 4TNVA 2BYNA 2YOEA 2XQ6A 4HQPA 5BP0A 5HCMA 4UM3A 4UM3P 3RI5A 4HFCA 4UY2A 2XNUA 2YMDA 3RIAA 5J5FA 4HFIA 2PH9A 5TVCA 4UM3S 2XQ3A 2ZJVA 4A98A 3U8KA 3P50A 5FJVA 3TLSA
chains in the Genus database with same CATH topology
4ILBA 3UQ4A 4COFA 3ZDGA 5AFNA 2BR7A 3LSVA 3RIFA 4ZZCA 5J0ZA 2BR8A 2XQ7A 3JAFA 4B5DA 3EI0A 1UV6A 3EAMA 3EHZA 3SQ6A 4HFBA 3RQWA 5IUXA 3TLTA 4ILCA 2XZ6A 4IREA 4ILAA 4FRRA 5AFMB 4X5TA 5J5GA 4QH5A 4LMLA 2W8FA 2BJ0A 4IL9A 2BG9B 2WNCA 3JAEA 2ZJUA 4XHEA 4QABA 4ZZBA 2Y57A 3UU6A 4F8HA 2YKSA 5AFLA 2YMEA 2XQ8A 4AFGA 4TWDA 4WV9A 4ALXA 5KZUA 4ZRUA 2XQAA 4IL4A 4HFDA 2C9TA 2XQ5A 3C84A 4QACA 4A97A 4HFEA 5CO5A 2UZ6A 3ZKRA 4UXUA 3SIOA 3WTMA 2WN9A 3IGQA 2XYTA 3SQ9A 3WTJA 4Z90A 5HEHA 5AINA 4PIRA 3UU8A 2XQ4A 4TWHA 5KE4A 2X00D 4ZK4A 5AFKA 2XYSA 3UU4A 2W8GA 3PMZA 2BYRA 4ZR6A 5LG3A 4LMKA 1UW6A 5L4EA 5HEUA 3PEOA 3WTLA 2Y56A 2Y7YA 5HEJA 2Y58A 3WTNA 5AFHA 3WTIA 3SH1A 5J5IA 5AFMA 4BFQA 3UQ7A 3U8JA 2BG9E 2PGZA 2BYPA 2BG9A 5BRXA 4QAAA 5JMEA 4ZK1A 3WTOA 4Z91A 2XQ9A 3U8NA 2BYSA 3WTKA 3WTHA 4NZBA 2X00A 4ZJTA 4AFHA 3ZDHA 3WIPA 5HEOA 4QH1A 2BYQA 3UUBA 4HFHA 4D01A 2BG9C 5HEGA 3TLUA 3TLVA 4TWFA 3TLWA 3RQUA 4NPPA 3RHWA 5LXBA 4TNWA 4UM1A 2XNTA 3GUAA 4QH4A 3U8MA 2WNLA 5L47A 2WNJA 5J5HA 5HCJA 2XZ5A 5L4HA 4BQTA 2QC1B 4EZ1A 5CFBA 3C79A 3U8LA 2WZYA 2Y54A 3T4MA 2XNVA 4AFTA 5BW2A 5AFJA 5SYOA 1I9BA 3JADA 1UX2A 4XK9A 3UU3A 4LMJA 4DBMA 3UU5A 2VL0A 4ZJSA 3P4WA 2YN6A 4TNVA 2BYNA 2YOEA 2XQ6A 4HQPA 5BP0A 5HCMA 4UM3A 4UM3P 3RI5A 4HFCA 4UY2A 2XNUA 2YMDA 3RIAA 5J5FA 4HFIA 2PH9A 5TVCA 4UM3S 2XQ3A 2ZJVA 4A98A 3U8KA 3P50A 5FJVA 3TLSA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4ILB A;  3UQ4 A;  4COF A;  3ZDG A;  5AFN A;  2BR7 A;  3LSV A;  3RIF A;  4ZZC A;  5J0Z A;  2BR8 A;  2XQ7 A;  3JAF A;  4B5D A;  3EI0 A;  1UV6 A;  3EAM A;  3EHZ A;  3SQ6 A;  4HFB A;  3RQW A;  5IUX A;  3TLT A;  4ILC A;  2XZ6 A;  4IRE A;  4ILA A;  4FRR A;  5AFM B;  4X5T A;  5J5G A;  4QH5 A;  4LML A;  2W8F A;  2BJ0 A;  4IL9 A;  2BG9 B;  2WNC A;  3JAE A;  2ZJU A;  4XHE A;  4QAB A;  4ZZB A;  2Y57 A;  3UU6 A;  4F8H A;  2YKS A;  5AFL A;  2YME A;  2XQ8 A;  4AFG A;  4TWD A;  4WV9 A;  4ALX A;  5KZU A;  4ZRU A;  2XQA A;  4IL4 A;  4HFD A;  2C9T A;  2XQ5 A;  3C84 A;  4QAC A;  4A97 A;  4HFE A;  5CO5 A;  2UZ6 A;  3ZKR A;  4UXU A;  3SIO A;  3WTM A;  2WN9 A;  3IGQ A;  2XYT A;  3SQ9 A;  3WTJ A;  4Z90 A;  5HEH A;  5AIN A;  4PIR A;  3UU8 A;  2XQ4 A;  4TWH A;  5KE4 A;  2X00 D;  4ZK4 A;  5AFK A;  2XYS A;  3UU4 A;  2W8G A;  3PMZ A;  2BYR A;  4ZR6 A;  5LG3 A;  4LMK A;  1UW6 A;  5L4E A;  5HEU A;  3PEO A;  3WTL A;  2Y56 A;  2Y7Y A;  5HEJ A;  2Y58 A;  3WTN A;  5AFH A;  3WTI A;  3SH1 A;  5J5I A;  5AFM A;  4BFQ A;  3UQ7 A;  3U8J A;  2BG9 E;  2PGZ A;  2BYP A;  2BG9 A;  5BRX A;  4QAA A;  5JME A;  4ZK1 A;  3WTO A;  4Z91 A;  2XQ9 A;  3U8N A;  2BYS A;  3WTK A;  3WTH A;  4NZB A;  2X00 A;  4ZJT A;  4AFH A;  3ZDH A;  3WIP A;  5HEO A;  4QH1 A;  2BYQ A;  3UUB A;  4HFH A;  4D01 A;  2BG9 C;  5HEG A;  3TLU A;  3TLV A;  4TWF A;  3TLW A;  3RQU A;  4NPP A;  3RHW A;  5LXB A;  4TNW A;  4UM1 A;  2XNT A;  3GUA A;  4QH4 A;  3U8M A;  2WNL A;  5L47 A;  2WNJ A;  5J5H A;  5HCJ A;  2XZ5 A;  5L4H A;  4BQT A;  2QC1 B;  4EZ1 A;  5CFB A;  3C79 A;  3U8L A;  2WZY A;  2Y54 A;  3T4M A;  2XNV A;  4AFT A;  5BW2 A;  5AFJ A;  5SYO A;  1I9B A;  3JAD A;  1UX2 A;  4XK9 A;  3UU3 A;  4LMJ A;  4DBM A;  3UU5 A;  2VL0 A;  4ZJS A;  3P4W A;  2YN6 A;  4TNV A;  2BYN A;  2YOE A;  2XQ6 A;  4HQP A;  5BP0 A;  5HCM A;  4UM3 A;  4UM3 P;  3RI5 A;  4HFC A;  4UY2 A;  2XNU A;  2YMD A;  3RIA A;  5J5F A;  4HFI A;  2PH9 A;  5TVC A;  4UM3 S;  2XQ3 A;  2ZJV A;  4A98 A;  3U8K A;  3P50 A;  5FJV A;  3TLS A; 
#chains in the Genus database with same CATH topology
 4ILB A;  3UQ4 A;  4COF A;  3ZDG A;  5AFN A;  2BR7 A;  3LSV A;  3RIF A;  4ZZC A;  5J0Z A;  2BR8 A;  2XQ7 A;  3JAF A;  4B5D A;  3EI0 A;  1UV6 A;  3EAM A;  3EHZ A;  3SQ6 A;  4HFB A;  3RQW A;  5IUX A;  3TLT A;  4ILC A;  2XZ6 A;  4IRE A;  4ILA A;  4FRR A;  5AFM B;  4X5T A;  5J5G A;  4QH5 A;  4LML A;  2W8F A;  2BJ0 A;  4IL9 A;  2BG9 B;  2WNC A;  3JAE A;  2ZJU A;  4XHE A;  4QAB A;  4ZZB A;  2Y57 A;  3UU6 A;  4F8H A;  2YKS A;  5AFL A;  2YME A;  2XQ8 A;  4AFG A;  4TWD A;  4WV9 A;  4ALX A;  5KZU A;  4ZRU A;  2XQA A;  4IL4 A;  4HFD A;  2C9T A;  2XQ5 A;  3C84 A;  4QAC A;  4A97 A;  4HFE A;  5CO5 A;  2UZ6 A;  3ZKR A;  4UXU A;  3SIO A;  3WTM A;  2WN9 A;  3IGQ A;  2XYT A;  3SQ9 A;  3WTJ A;  4Z90 A;  5HEH A;  5AIN A;  4PIR A;  3UU8 A;  2XQ4 A;  4TWH A;  5KE4 A;  2X00 D;  4ZK4 A;  5AFK A;  2XYS A;  3UU4 A;  2W8G A;  3PMZ A;  2BYR A;  4ZR6 A;  5LG3 A;  4LMK A;  1UW6 A;  5L4E A;  5HEU A;  3PEO A;  3WTL A;  2Y56 A;  2Y7Y A;  5HEJ A;  2Y58 A;  3WTN A;  5AFH A;  3WTI A;  3SH1 A;  5J5I A;  5AFM A;  4BFQ A;  3UQ7 A;  3U8J A;  2BG9 E;  2PGZ A;  2BYP A;  2BG9 A;  5BRX A;  4QAA A;  5JME A;  4ZK1 A;  3WTO A;  4Z91 A;  2XQ9 A;  3U8N A;  2BYS A;  3WTK A;  3WTH A;  4NZB A;  2X00 A;  4ZJT A;  4AFH A;  3ZDH A;  3WIP A;  5HEO A;  4QH1 A;  2BYQ A;  3UUB A;  4HFH A;  4D01 A;  2BG9 C;  5HEG A;  3TLU A;  3TLV A;  4TWF A;  3TLW A;  3RQU A;  4NPP A;  3RHW A;  5LXB A;  4TNW A;  4UM1 A;  2XNT A;  3GUA A;  4QH4 A;  3U8M A;  2WNL A;  5L47 A;  2WNJ A;  5J5H A;  5HCJ A;  2XZ5 A;  5L4H A;  4BQT A;  2QC1 B;  4EZ1 A;  5CFB A;  3C79 A;  3U8L A;  2WZY A;  2Y54 A;  3T4M A;  2XNV A;  4AFT A;  5BW2 A;  5AFJ A;  5SYO A;  1I9B A;  3JAD A;  1UX2 A;  4XK9 A;  3UU3 A;  4LMJ A;  4DBM A;  3UU5 A;  2VL0 A;  4ZJS A;  3P4W A;  2YN6 A;  4TNV A;  2BYN A;  2YOE A;  2XQ6 A;  4HQP A;  5BP0 A;  5HCM A;  4UM3 A;  4UM3 P;  3RI5 A;  4HFC A;  4UY2 A;  2XNU A;  2YMD A;  3RIA A;  5J5F A;  4HFI A;  2PH9 A;  5TVC A;  4UM3 S;  2XQ3 A;  2ZJV A;  4A98 A;  3U8K A;  3P50 A;  5FJV A;  3TLS A; 
#chains in the Genus database with same CATH homology
 4ILB A;  3UQ4 A;  4COF A;  3ZDG A;  5AFN A;  2BR7 A;  3LSV A;  3RIF A;  4ZZC A;  5J0Z A;  2BR8 A;  2XQ7 A;  3JAF A;  4B5D A;  3EI0 A;  1UV6 A;  3EAM A;  3EHZ A;  3SQ6 A;  4HFB A;  3RQW A;  5IUX A;  3TLT A;  4ILC A;  2XZ6 A;  4IRE A;  4ILA A;  4FRR A;  5AFM B;  4X5T A;  5J5G A;  4QH5 A;  4LML A;  2W8F A;  2BJ0 A;  4IL9 A;  2BG9 B;  2WNC A;  3JAE A;  2ZJU A;  4XHE A;  4QAB A;  4ZZB A;  2Y57 A;  3UU6 A;  4F8H A;  2YKS A;  5AFL A;  2YME A;  2XQ8 A;  4AFG A;  4TWD A;  4WV9 A;  4ALX A;  5KZU A;  4ZRU A;  2XQA A;  4IL4 A;  4HFD A;  2C9T A;  2XQ5 A;  3C84 A;  4QAC A;  4A97 A;  4HFE A;  5CO5 A;  2UZ6 A;  3ZKR A;  4UXU A;  3SIO A;  3WTM A;  2WN9 A;  3IGQ A;  2XYT A;  3SQ9 A;  3WTJ A;  4Z90 A;  5HEH A;  5AIN A;  4PIR A;  3UU8 A;  2XQ4 A;  4TWH A;  5KE4 A;  2X00 D;  4ZK4 A;  5AFK A;  2XYS A;  3UU4 A;  2W8G A;  3PMZ A;  2BYR A;  4ZR6 A;  5LG3 A;  4LMK A;  1UW6 A;  5L4E A;  5HEU A;  3PEO A;  3WTL A;  2Y56 A;  2Y7Y A;  5HEJ A;  2Y58 A;  3WTN A;  5AFH A;  3WTI A;  3SH1 A;  5J5I A;  5AFM A;  4BFQ A;  3UQ7 A;  3U8J A;  2BG9 E;  2PGZ A;  2BYP A;  2BG9 A;  5BRX A;  4QAA A;  5JME A;  4ZK1 A;  3WTO A;  4Z91 A;  2XQ9 A;  3U8N A;  2BYS A;  3WTK A;  3WTH A;  4NZB A;  2X00 A;  4ZJT A;  4AFH A;  3ZDH A;  3WIP A;  5HEO A;  4QH1 A;  2BYQ A;  3UUB A;  4HFH A;  4D01 A;  2BG9 C;  5HEG A;  3TLU A;  3TLV A;  4TWF A;  3TLW A;  3RQU A;  4NPP A;  3RHW A;  5LXB A;  4TNW A;  4UM1 A;  2XNT A;  3GUA A;  4QH4 A;  3U8M A;  2WNL A;  5L47 A;  2WNJ A;  5J5H A;  5HCJ A;  2XZ5 A;  5L4H A;  4BQT A;  2QC1 B;  4EZ1 A;  5CFB A;  3C79 A;  3U8L A;  2WZY A;  2Y54 A;  3T4M A;  2XNV A;  4AFT A;  5BW2 A;  5AFJ A;  5SYO A;  1I9B A;  3JAD A;  1UX2 A;  4XK9 A;  3UU3 A;  4LMJ A;  4DBM A;  3UU5 A;  2VL0 A;  4ZJS A;  3P4W A;  2YN6 A;  4TNV A;  2BYN A;  2YOE A;  2XQ6 A;  4HQP A;  5BP0 A;  5HCM A;  4UM3 A;  4UM3 P;  3RI5 A;  4HFC A;  4UY2 A;  2XNU A;  2YMD A;  3RIA A;  5J5F A;  4HFI A;  2PH9 A;  5TVC A;  4UM3 S;  2XQ3 A;  2ZJV A;  4A98 A;  3U8K A;  3P50 A;  5FJV A;  3TLS A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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