5AFKA

Alpha7-achbp in complex with lobeline and fragment 2
Total Genus 45
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
45
sequence length
205
structure length
205
Chain Sequence
GEFQRKLYKELVKNYNPDVIPTQRDRPVTVYFSLSLLQIMDVDEKNQVVDVVFWLQMSWTDHYLQWNVSEYPGVKQVSVPISSLWVPDLAAYNAISKPEVLTPQLALVNSSGHVQYLPSIRQRFSCDVSGVDTESGATCKLKFGSWTHHSRELDLQMQEADISGYIPYSRFELVGVTQKRSERFYECCKEPYPDVTFTVTFRKKG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Molecular Blueprint of Allosteric Binding Sites in a Homologue of the Agonist-Binding Domain of the Alpha7 Nicotinic Acetylcholine Receptor.
pubmed doi rcsb
molecule tags Transport protein
source organism Homo sapiens
molecule keywords ACETYLCHOLINE-BINDING PROTEIN, NEURONAL ACETYLCHOLINE RECEPT
total genus 45
structure length 205
sequence length 205
chains with identical sequence B, C, D, E
ec nomenclature
pdb deposition date 2015-01-22
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.170.10 Mainly Beta Distorted Sandwich Acetylcholine Binding Protein; Chain: A, Neurotransmitter-gated ion-channel ligand-binding domain 5afkA00
3UQ7A 5HCJA 4X5TA 3ZDHA 3RQUA 4TWFA 2BR7A 3TLSA 3ZDGA 2XQ6A 3WTOA 1UV6A 2PH9A 2UZ6A 5IUXA 4B5DA 3SQ6A 3UUBA 4QH1A 3TLTA 2BYPA 2W8FA 4DBMA 5CFBA 2WNCA 5SYOA 2YMDA 3UU8A 2XYTA 2XNUA 2BG9C 3SIOA 3UU3A 2XZ6A 4Z90A 5AFKA 4HFBA 2YMEA 3T4MA 5LXBA 3TLUA 3PEOA 5CO5A 5HEOA 4BQTA 3RI5A 4LMLA 3UU5A 2X00D 3JAFA 2WZYA 1I9BA 3U8NA 5AFMA 4ALXA 3UU6A 4TNVA 2BG9A 5HEGA 2XNVA 4ZJTA 3PMZA 2XQ8A 5AFJA 4AFHA 2WNLA 5FJVA 2XZ5A 2PGZA 3SQ9A 3WTLA 5J5FA 2W8GA 5J0ZA 3U8MA 3WTHA 3UU4A 3WIPA 1UW6A 3SH1A 3EAMA 2BYNA 2BYQA 3LSVA 3WTKA 2Y54A 3P4WA 3C79A 4TNWA 5L4HA 5J5HA 3UQ4A 2YKSA 2Y56A 4F8HA 4UXUA 5L47A 4COFA 4QAAA 1UX2A 2BJ0A 4TWHA 2XQAA 2XQ4A 5KZUA 4ZZBA 5J5GA 2XQ9A 2XQ3A 4NZBA 4ZR6A 4D01A 4IREA 4IL9A 4AFGA 2X00A 2Y7YA 5JMEA 2QC1B 3TLVA 4LMJA 4QH5A 4A98A 4XHEA 4HFHA 4WV9A 4ZK4A 4Z91A 3RIFA 5AFLA 4UM1A 4FRRA 4UM3S 4NPPA 2ZJVA 4AFTA 4LMKA 3WTNA 2VL0A 4UM3A 2YOEA 4ILAA 3TLWA 3P50A 5HEHA 3WTIA 4TWDA 4HFCA 4UM3P 5BW2A 3WTMA 5BRXA 4HFEA 2XQ7A 5AFHA 4ZRUA 5BP0A 5LG3A 3JAEA 2BYRA 2XQ5A 4HFIA 3U8JA 4BFQA 5AFMB 4XK9A 4ZJSA 2BG9B 4ILCA 4QABA 5HEUA 4ILBA 4EZ1A 2BR8A 3ZKRA 5L4EA 3EI0A 3IGQA 4QH4A 5J5IA 5KE4A 5AINA 3JADA 3RQWA 3WTJA 5AFNA 3RIAA 3U8KA 4ZZCA 3U8LA 4ZK1A 4QACA 5HEJA 4A97A 4HFDA 2XNTA 2Y57A 2WNJA 4HQPA 3C84A 2YN6A 2Y58A 3EHZA 4PIRA 2BYSA 2BG9E 2ZJUA 3GUAA 5HCMA 4IL4A 2C9TA 2WN9A 2XYSA 5TVCA 3RHWA 4UY2A
chains in the Genus database with same CATH superfamily
3UQ7A 5HCJA 4X5TA 3ZDHA 3RQUA 4TWFA 2BR7A 3TLSA 3ZDGA 2XQ6A 3WTOA 1UV6A 2PH9A 2UZ6A 5IUXA 4B5DA 3SQ6A 3UUBA 4QH1A 3TLTA 2BYPA 2W8FA 4DBMA 5CFBA 2WNCA 5SYOA 2YMDA 3UU8A 2XYTA 2XNUA 2BG9C 3SIOA 3UU3A 2XZ6A 4Z90A 5AFKA 4HFBA 2YMEA 3T4MA 5LXBA 3TLUA 3PEOA 5CO5A 5HEOA 4BQTA 3RI5A 4LMLA 3UU5A 2X00D 3JAFA 2WZYA 1I9BA 3U8NA 5AFMA 4ALXA 3UU6A 4TNVA 2BG9A 5HEGA 2XNVA 4ZJTA 3PMZA 2XQ8A 5AFJA 4AFHA 2WNLA 5FJVA 2XZ5A 2PGZA 3SQ9A 3WTLA 5J5FA 2W8GA 5J0ZA 3U8MA 3WTHA 3UU4A 3WIPA 1UW6A 3SH1A 3EAMA 2BYNA 2BYQA 3LSVA 3WTKA 2Y54A 3P4WA 3C79A 4TNWA 5L4HA 5J5HA 3UQ4A 2YKSA 2Y56A 4F8HA 4UXUA 5L47A 4COFA 4QAAA 1UX2A 2BJ0A 4TWHA 2XQAA 2XQ4A 5KZUA 4ZZBA 5J5GA 2XQ9A 2XQ3A 4NZBA 4ZR6A 4D01A 4IREA 4IL9A 4AFGA 2X00A 2Y7YA 5JMEA 2QC1B 3TLVA 4LMJA 4QH5A 4A98A 4XHEA 4HFHA 4WV9A 4ZK4A 4Z91A 3RIFA 5AFLA 4UM1A 4FRRA 4UM3S 4NPPA 2ZJVA 4AFTA 4LMKA 3WTNA 2VL0A 4UM3A 2YOEA 4ILAA 3TLWA 3P50A 5HEHA 3WTIA 4TWDA 4HFCA 4UM3P 5BW2A 3WTMA 5BRXA 4HFEA 2XQ7A 5AFHA 4ZRUA 5BP0A 5LG3A 3JAEA 2BYRA 2XQ5A 4HFIA 3U8JA 4BFQA 5AFMB 4XK9A 4ZJSA 2BG9B 4ILCA 4QABA 5HEUA 4ILBA 4EZ1A 2BR8A 3ZKRA 5L4EA 3EI0A 3IGQA 4QH4A 5J5IA 5KE4A 5AINA 3JADA 3RQWA 3WTJA 5AFNA 3RIAA 3U8KA 4ZZCA 3U8LA 4ZK1A 4QACA 5HEJA 4A97A 4HFDA 2XNTA 2Y57A 2WNJA 4HQPA 3C84A 2YN6A 2Y58A 3EHZA 4PIRA 2BYSA 2BG9E 2ZJUA 3GUAA 5HCMA 4IL4A 2C9TA 2WN9A 2XYSA 5TVCA 3RHWA 4UY2A
chains in the Genus database with same CATH topology
3UQ7A 5HCJA 4X5TA 3ZDHA 3RQUA 4TWFA 2BR7A 3TLSA 3ZDGA 2XQ6A 3WTOA 1UV6A 2PH9A 2UZ6A 5IUXA 4B5DA 3SQ6A 3UUBA 4QH1A 3TLTA 2BYPA 2W8FA 4DBMA 5CFBA 2WNCA 5SYOA 2YMDA 3UU8A 2XYTA 2XNUA 2BG9C 3SIOA 3UU3A 2XZ6A 4Z90A 5AFKA 4HFBA 2YMEA 3T4MA 5LXBA 3TLUA 3PEOA 5CO5A 5HEOA 4BQTA 3RI5A 4LMLA 3UU5A 2X00D 3JAFA 2WZYA 1I9BA 3U8NA 5AFMA 4ALXA 3UU6A 4TNVA 2BG9A 5HEGA 2XNVA 4ZJTA 3PMZA 2XQ8A 5AFJA 4AFHA 2WNLA 5FJVA 2XZ5A 2PGZA 3SQ9A 3WTLA 5J5FA 2W8GA 5J0ZA 3U8MA 3WTHA 3UU4A 3WIPA 1UW6A 3SH1A 3EAMA 2BYNA 2BYQA 3LSVA 3WTKA 2Y54A 3P4WA 3C79A 4TNWA 5L4HA 5J5HA 3UQ4A 2YKSA 2Y56A 4F8HA 4UXUA 5L47A 4COFA 4QAAA 1UX2A 2BJ0A 4TWHA 2XQAA 2XQ4A 5KZUA 4ZZBA 5J5GA 2XQ9A 2XQ3A 4NZBA 4ZR6A 4D01A 4IREA 4IL9A 4AFGA 2X00A 2Y7YA 5JMEA 2QC1B 3TLVA 4LMJA 4QH5A 4A98A 4XHEA 4HFHA 4WV9A 4ZK4A 4Z91A 3RIFA 5AFLA 4UM1A 4FRRA 4UM3S 4NPPA 2ZJVA 4AFTA 4LMKA 3WTNA 2VL0A 4UM3A 2YOEA 4ILAA 3TLWA 3P50A 5HEHA 3WTIA 4TWDA 4HFCA 4UM3P 5BW2A 3WTMA 5BRXA 4HFEA 2XQ7A 5AFHA 4ZRUA 5BP0A 5LG3A 3JAEA 2BYRA 2XQ5A 4HFIA 3U8JA 4BFQA 5AFMB 4XK9A 4ZJSA 2BG9B 4ILCA 4QABA 5HEUA 4ILBA 4EZ1A 2BR8A 3ZKRA 5L4EA 3EI0A 3IGQA 4QH4A 5J5IA 5KE4A 5AINA 3JADA 3RQWA 3WTJA 5AFNA 3RIAA 3U8KA 4ZZCA 3U8LA 4ZK1A 4QACA 5HEJA 4A97A 4HFDA 2XNTA 2Y57A 2WNJA 4HQPA 3C84A 2YN6A 2Y58A 3EHZA 4PIRA 2BYSA 2BG9E 2ZJUA 3GUAA 5HCMA 4IL4A 2C9TA 2WN9A 2XYSA 5TVCA 3RHWA 4UY2A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3UQ7 A;  5HCJ A;  4X5T A;  3ZDH A;  3RQU A;  4TWF A;  2BR7 A;  3TLS A;  3ZDG A;  2XQ6 A;  3WTO A;  1UV6 A;  2PH9 A;  2UZ6 A;  5IUX A;  4B5D A;  3SQ6 A;  3UUB A;  4QH1 A;  3TLT A;  2BYP A;  2W8F A;  4DBM A;  5CFB A;  2WNC A;  5SYO A;  2YMD A;  3UU8 A;  2XYT A;  2XNU A;  2BG9 C;  3SIO A;  3UU3 A;  2XZ6 A;  4Z90 A;  5AFK A;  4HFB A;  2YME A;  3T4M A;  5LXB A;  3TLU A;  3PEO A;  5CO5 A;  5HEO A;  4BQT A;  3RI5 A;  4LML A;  3UU5 A;  2X00 D;  3JAF A;  2WZY A;  1I9B A;  3U8N A;  5AFM A;  4ALX A;  3UU6 A;  4TNV A;  2BG9 A;  5HEG A;  2XNV A;  4ZJT A;  3PMZ A;  2XQ8 A;  5AFJ A;  4AFH A;  2WNL A;  5FJV A;  2XZ5 A;  2PGZ A;  3SQ9 A;  3WTL A;  5J5F A;  2W8G A;  5J0Z A;  3U8M A;  3WTH A;  3UU4 A;  3WIP A;  1UW6 A;  3SH1 A;  3EAM A;  2BYN A;  2BYQ A;  3LSV A;  3WTK A;  2Y54 A;  3P4W A;  3C79 A;  4TNW A;  5L4H A;  5J5H A;  3UQ4 A;  2YKS A;  2Y56 A;  4F8H A;  4UXU A;  5L47 A;  4COF A;  4QAA A;  1UX2 A;  2BJ0 A;  4TWH A;  2XQA A;  2XQ4 A;  5KZU A;  4ZZB A;  5J5G A;  2XQ9 A;  2XQ3 A;  4NZB A;  4ZR6 A;  4D01 A;  4IRE A;  4IL9 A;  4AFG A;  2X00 A;  2Y7Y A;  5JME A;  2QC1 B;  3TLV A;  4LMJ A;  4QH5 A;  4A98 A;  4XHE A;  4HFH A;  4WV9 A;  4ZK4 A;  4Z91 A;  3RIF A;  5AFL A;  4UM1 A;  4FRR A;  4UM3 S;  4NPP A;  2ZJV A;  4AFT A;  4LMK A;  3WTN A;  2VL0 A;  4UM3 A;  2YOE A;  4ILA A;  3TLW A;  3P50 A;  5HEH A;  3WTI A;  4TWD A;  4HFC A;  4UM3 P;  5BW2 A;  3WTM A;  5BRX A;  4HFE A;  2XQ7 A;  5AFH A;  4ZRU A;  5BP0 A;  5LG3 A;  3JAE A;  2BYR A;  2XQ5 A;  4HFI A;  3U8J A;  4BFQ A;  5AFM B;  4XK9 A;  4ZJS A;  2BG9 B;  4ILC A;  4QAB A;  5HEU A;  4ILB A;  4EZ1 A;  2BR8 A;  3ZKR A;  5L4E A;  3EI0 A;  3IGQ A;  4QH4 A;  5J5I A;  5KE4 A;  5AIN A;  3JAD A;  3RQW A;  3WTJ A;  5AFN A;  3RIA A;  3U8K A;  4ZZC A;  3U8L A;  4ZK1 A;  4QAC A;  5HEJ A;  4A97 A;  4HFD A;  2XNT A;  2Y57 A;  2WNJ A;  4HQP A;  3C84 A;  2YN6 A;  2Y58 A;  3EHZ A;  4PIR A;  2BYS A;  2BG9 E;  2ZJU A;  3GUA A;  5HCM A;  4IL4 A;  2C9T A;  2WN9 A;  2XYS A;  5TVC A;  3RHW A;  4UY2 A; 
#chains in the Genus database with same CATH topology
 3UQ7 A;  5HCJ A;  4X5T A;  3ZDH A;  3RQU A;  4TWF A;  2BR7 A;  3TLS A;  3ZDG A;  2XQ6 A;  3WTO A;  1UV6 A;  2PH9 A;  2UZ6 A;  5IUX A;  4B5D A;  3SQ6 A;  3UUB A;  4QH1 A;  3TLT A;  2BYP A;  2W8F A;  4DBM A;  5CFB A;  2WNC A;  5SYO A;  2YMD A;  3UU8 A;  2XYT A;  2XNU A;  2BG9 C;  3SIO A;  3UU3 A;  2XZ6 A;  4Z90 A;  5AFK A;  4HFB A;  2YME A;  3T4M A;  5LXB A;  3TLU A;  3PEO A;  5CO5 A;  5HEO A;  4BQT A;  3RI5 A;  4LML A;  3UU5 A;  2X00 D;  3JAF A;  2WZY A;  1I9B A;  3U8N A;  5AFM A;  4ALX A;  3UU6 A;  4TNV A;  2BG9 A;  5HEG A;  2XNV A;  4ZJT A;  3PMZ A;  2XQ8 A;  5AFJ A;  4AFH A;  2WNL A;  5FJV A;  2XZ5 A;  2PGZ A;  3SQ9 A;  3WTL A;  5J5F A;  2W8G A;  5J0Z A;  3U8M A;  3WTH A;  3UU4 A;  3WIP A;  1UW6 A;  3SH1 A;  3EAM A;  2BYN A;  2BYQ A;  3LSV A;  3WTK A;  2Y54 A;  3P4W A;  3C79 A;  4TNW A;  5L4H A;  5J5H A;  3UQ4 A;  2YKS A;  2Y56 A;  4F8H A;  4UXU A;  5L47 A;  4COF A;  4QAA A;  1UX2 A;  2BJ0 A;  4TWH A;  2XQA A;  2XQ4 A;  5KZU A;  4ZZB A;  5J5G A;  2XQ9 A;  2XQ3 A;  4NZB A;  4ZR6 A;  4D01 A;  4IRE A;  4IL9 A;  4AFG A;  2X00 A;  2Y7Y A;  5JME A;  2QC1 B;  3TLV A;  4LMJ A;  4QH5 A;  4A98 A;  4XHE A;  4HFH A;  4WV9 A;  4ZK4 A;  4Z91 A;  3RIF A;  5AFL A;  4UM1 A;  4FRR A;  4UM3 S;  4NPP A;  2ZJV A;  4AFT A;  4LMK A;  3WTN A;  2VL0 A;  4UM3 A;  2YOE A;  4ILA A;  3TLW A;  3P50 A;  5HEH A;  3WTI A;  4TWD A;  4HFC A;  4UM3 P;  5BW2 A;  3WTM A;  5BRX A;  4HFE A;  2XQ7 A;  5AFH A;  4ZRU A;  5BP0 A;  5LG3 A;  3JAE A;  2BYR A;  2XQ5 A;  4HFI A;  3U8J A;  4BFQ A;  5AFM B;  4XK9 A;  4ZJS A;  2BG9 B;  4ILC A;  4QAB A;  5HEU A;  4ILB A;  4EZ1 A;  2BR8 A;  3ZKR A;  5L4E A;  3EI0 A;  3IGQ A;  4QH4 A;  5J5I A;  5KE4 A;  5AIN A;  3JAD A;  3RQW A;  3WTJ A;  5AFN A;  3RIA A;  3U8K A;  4ZZC A;  3U8L A;  4ZK1 A;  4QAC A;  5HEJ A;  4A97 A;  4HFD A;  2XNT A;  2Y57 A;  2WNJ A;  4HQP A;  3C84 A;  2YN6 A;  2Y58 A;  3EHZ A;  4PIR A;  2BYS A;  2BG9 E;  2ZJU A;  3GUA A;  5HCM A;  4IL4 A;  2C9T A;  2WN9 A;  2XYS A;  5TVC A;  3RHW A;  4UY2 A; 
#chains in the Genus database with same CATH homology
 3UQ7 A;  5HCJ A;  4X5T A;  3ZDH A;  3RQU A;  4TWF A;  2BR7 A;  3TLS A;  3ZDG A;  2XQ6 A;  3WTO A;  1UV6 A;  2PH9 A;  2UZ6 A;  5IUX A;  4B5D A;  3SQ6 A;  3UUB A;  4QH1 A;  3TLT A;  2BYP A;  2W8F A;  4DBM A;  5CFB A;  2WNC A;  5SYO A;  2YMD A;  3UU8 A;  2XYT A;  2XNU A;  2BG9 C;  3SIO A;  3UU3 A;  2XZ6 A;  4Z90 A;  5AFK A;  4HFB A;  2YME A;  3T4M A;  5LXB A;  3TLU A;  3PEO A;  5CO5 A;  5HEO A;  4BQT A;  3RI5 A;  4LML A;  3UU5 A;  2X00 D;  3JAF A;  2WZY A;  1I9B A;  3U8N A;  5AFM A;  4ALX A;  3UU6 A;  4TNV A;  2BG9 A;  5HEG A;  2XNV A;  4ZJT A;  3PMZ A;  2XQ8 A;  5AFJ A;  4AFH A;  2WNL A;  5FJV A;  2XZ5 A;  2PGZ A;  3SQ9 A;  3WTL A;  5J5F A;  2W8G A;  5J0Z A;  3U8M A;  3WTH A;  3UU4 A;  3WIP A;  1UW6 A;  3SH1 A;  3EAM A;  2BYN A;  2BYQ A;  3LSV A;  3WTK A;  2Y54 A;  3P4W A;  3C79 A;  4TNW A;  5L4H A;  5J5H A;  3UQ4 A;  2YKS A;  2Y56 A;  4F8H A;  4UXU A;  5L47 A;  4COF A;  4QAA A;  1UX2 A;  2BJ0 A;  4TWH A;  2XQA A;  2XQ4 A;  5KZU A;  4ZZB A;  5J5G A;  2XQ9 A;  2XQ3 A;  4NZB A;  4ZR6 A;  4D01 A;  4IRE A;  4IL9 A;  4AFG A;  2X00 A;  2Y7Y A;  5JME A;  2QC1 B;  3TLV A;  4LMJ A;  4QH5 A;  4A98 A;  4XHE A;  4HFH A;  4WV9 A;  4ZK4 A;  4Z91 A;  3RIF A;  5AFL A;  4UM1 A;  4FRR A;  4UM3 S;  4NPP A;  2ZJV A;  4AFT A;  4LMK A;  3WTN A;  2VL0 A;  4UM3 A;  2YOE A;  4ILA A;  3TLW A;  3P50 A;  5HEH A;  3WTI A;  4TWD A;  4HFC A;  4UM3 P;  5BW2 A;  3WTM A;  5BRX A;  4HFE A;  2XQ7 A;  5AFH A;  4ZRU A;  5BP0 A;  5LG3 A;  3JAE A;  2BYR A;  2XQ5 A;  4HFI A;  3U8J A;  4BFQ A;  5AFM B;  4XK9 A;  4ZJS A;  2BG9 B;  4ILC A;  4QAB A;  5HEU A;  4ILB A;  4EZ1 A;  2BR8 A;  3ZKR A;  5L4E A;  3EI0 A;  3IGQ A;  4QH4 A;  5J5I A;  5KE4 A;  5AIN A;  3JAD A;  3RQW A;  3WTJ A;  5AFN A;  3RIA A;  3U8K A;  4ZZC A;  3U8L A;  4ZK1 A;  4QAC A;  5HEJ A;  4A97 A;  4HFD A;  2XNT A;  2Y57 A;  2WNJ A;  4HQP A;  3C84 A;  2YN6 A;  2Y58 A;  3EHZ A;  4PIR A;  2BYS A;  2BG9 E;  2ZJU A;  3GUA A;  5HCM A;  4IL4 A;  2C9T A;  2WN9 A;  2XYS A;  5TVC A;  3RHW A;  4UY2 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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