5AFM | Genus

Total Genus 41

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	41
sequence length	207
structure length	207
Chain Sequence	GEFQRKLYKELVKNYNPDVIPTQRDRPVTVYFSLSLLQIMDVDEKNQVVDVVFWLQMSWTDHYLQWNVSEYPGVKQVSVPISSLWVPDLAAYNAISKPEVLTPQLALVNSSGHVQYLPSIRQRFSCDVSGVDTESGATCKLKFGSWTHHSRELDLQMQEADISGYIPYSRFELVGVTQKRSERFYECCKEPYPDVTFTVTFRKKGRS

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

molecule tags	Transport protein
source organism	Homo sapiens
publication title	Molecular Blueprint of Allosteric Binding Sites in a Homologue of the Agonist-Binding Domain of the Alpha7 Nicotinic Acetylcholine Receptor. pubmed doi rcsb
molecule keywords	ACETYLCHOLINE-BINDING PROTEIN, NEURONAL ACETYLCHOLINE RECEPT
total genus	41
structure length	207
sequence length	207
ec nomenclature
pdb deposition date	2015-01-22

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
2.70.170.10	Mainly Beta	Distorted Sandwich	Acetylcholine Binding Protein; Chain: A,	Neurotransmitter-gated ion-channel ligand-binding domain	5afmB00

4QH1A 5HEHA 4HFBA 3C84A 3RHWA 3WIPA 3LSVA 2BG9C 1UW6A 3SQ6A 5HCMA 3SIOA 5J5GA 4LMLA 4TNVA 3C79A 2XNTA 4TWDA 3UU4A 5AFHA 3U8MA 3JAFA 4Z90A 4AFGA 4HFEA 3U8KA 5AFMA 4ILAA 2XQ3A 5SYOA 5TVCA 3TLTA 5AFNA 3ZKRA 2BYRA 2PGZA 4LMJA 4HFHA 3UU5A 3RIFA 4NZBA 4WV9A 3U8LA 2XQ4A 4QABA 5L4HA 2W8FA 2BR8A 3WTNA 2XQ8A 2XQ5A 4UM1A 5KZUA 4B5DA 1UX2A 3GUAA 2PH9A 3IGQA 3WTMA 4F8HA 5J5HA 4QACA 3ZDGA 2Y54A 4ILBA 3WTHA 3UQ4A 3EHZA 2XZ6A 4ZJSA 3U8NA 4Z91A 2BG9A 3WTJA 2XQ7A 3TLSA 4TWHA 3TLVA 4AFTA 4COFA 2WN9A 3EAMA 2YMDA 2WNJA 4UY2A 3WTKA 2X00D 1UV6A 5HEJA 3SQ9A 3UU3A 2XZ5A 3EI0A 5J0ZA 3PMZA 4XK9A 3WTLA 4HFIA 4QAAA 2BYPA 2WNLA 2Y7YA 3JAEA 3UU6A 4NPPA 3P50A 3SH1A 2BYNA 2C9TA 4ILCA 4XHEA 2Y57A 5AFMB 2XQ6A 4IL4A 3PEOA 5KE4A 5J5FA 3U8JA 4BFQA 5LG3A 4ZZCA 4A98A 4LMKA 5JMEA 4FRRA 5BP0A 4HQPA 4IL9A 3WTIA 5HCJA 4ZK4A 2ZJUA 4D01A 4UM3A 4ZJTA 4TWFA 2BJ0A 3JADA 4ZRUA 4EZ1A 5HEGA 4QH4A 5AFKA 4UM3S 2W8GA 2X00A 2BR7A 2VL0A 2XYTA 4HFCA 2Y58A 2YKSA 2YOEA 3RI5A 4A97A 3RIAA 4TNWA 3TLWA 4ZZBA 5L47A 4UXUA 4PIRA 3RQWA 5BRXA 2YN6A 5LXBA 5AINA 4BQTA 3RQUA 2XYSA 5CFBA 2WZYA 3ZDHA 2BYQA 2XQ9A 5FJVA 5HEOA 4X5TA 3TLUA 2BYSA 5J5IA 3UQ7A 4DBMA 5L4EA 5CO5A 4QH5A 4ZK1A 2XNVA 5BW2A 5IUXA 2ZJVA 3UUBA 3P4WA 3WTOA 2XQAA 2UZ6A 4ALXA 4IREA 3UU8A 4HFDA 2WNCA 2QC1B 5AFJA 5HEUA 5AFLA 2BG9E 2Y56A 2BG9B 2XNUA 3T4MA 1I9BA 4ZR6A 4AFHA 4UM3P 2YMEA
chains in the Genus database with same CATH superfamily

#chains in the Genus database with same CATH superfamily
 4QH1 A;  5HEH A;  4HFB A;  3C84 A;  3RHW A;  3WIP A;  3LSV A;  2BG9 C;  1UW6 A;  3SQ6 A;  5HCM A;  3SIO A;  5J5G A;  4LML A;  4TNV A;  3C79 A;  2XNT A;  4TWD A;  3UU4 A;  5AFH A;  3U8M A;  3JAF A;  4Z90 A;  4AFG A;  4HFE A;  3U8K A;  5AFM A;  4ILA A;  2XQ3 A;  5SYO A;  5TVC A;  3TLT A;  5AFN A;  3ZKR A;  2BYR A;  2PGZ A;  4LMJ A;  4HFH A;  3UU5 A;  3RIF A;  4NZB A;  4WV9 A;  3U8L A;  2XQ4 A;  4QAB A;  5L4H A;  2W8F A;  2BR8 A;  3WTN A;  2XQ8 A;  2XQ5 A;  4UM1 A;  5KZU A;  4B5D A;  1UX2 A;  3GUA A;  2PH9 A;  3IGQ A;  3WTM A;  4F8H A;  5J5H A;  4QAC A;  3ZDG A;  2Y54 A;  4ILB A;  3WTH A;  3UQ4 A;  3EHZ A;  2XZ6 A;  4ZJS A;  3U8N A;  4Z91 A;  2BG9 A;  3WTJ A;  2XQ7 A;  3TLS A;  4TWH A;  3TLV A;  4AFT A;  4COF A;  2WN9 A;  3EAM A;  2YMD A;  2WNJ A;  4UY2 A;  3WTK A;  2X00 D;  1UV6 A;  5HEJ A;  3SQ9 A;  3UU3 A;  2XZ5 A;  3EI0 A;  5J0Z A;  3PMZ A;  4XK9 A;  3WTL A;  4HFI A;  4QAA A;  2BYP A;  2WNL A;  2Y7Y A;  3JAE A;  3UU6 A;  4NPP A;  3P50 A;  3SH1 A;  2BYN A;  2C9T A;  4ILC A;  4XHE A;  2Y57 A;  5AFM B;  2XQ6 A;  4IL4 A;  3PEO A;  5KE4 A;  5J5F A;  3U8J A;  4BFQ A;  5LG3 A;  4ZZC A;  4A98 A;  4LMK A;  5JME A;  4FRR A;  5BP0 A;  4HQP A;  4IL9 A;  3WTI A;  5HCJ A;  4ZK4 A;  2ZJU A;  4D01 A;  4UM3 A;  4ZJT A;  4TWF A;  2BJ0 A;  3JAD A;  4ZRU A;  4EZ1 A;  5HEG A;  4QH4 A;  5AFK A;  4UM3 S;  2W8G A;  2X00 A;  2BR7 A;  2VL0 A;  2XYT A;  4HFC A;  2Y58 A;  2YKS A;  2YOE A;  3RI5 A;  4A97 A;  3RIA A;  4TNW A;  3TLW A;  4ZZB A;  5L47 A;  4UXU A;  4PIR A;  3RQW A;  5BRX A;  2YN6 A;  5LXB A;  5AIN A;  4BQT A;  3RQU A;  2XYS A;  5CFB A;  2WZY A;  3ZDH A;  2BYQ A;  2XQ9 A;  5FJV A;  5HEO A;  4X5T A;  3TLU A;  2BYS A;  5J5I A;  3UQ7 A;  4DBM A;  5L4E A;  5CO5 A;  4QH5 A;  4ZK1 A;  2XNV A;  5BW2 A;  5IUX A;  2ZJV A;  3UUB A;  3P4W A;  3WTO A;  2XQA A;  2UZ6 A;  4ALX A;  4IRE A;  3UU8 A;  4HFD A;  2WNC A;  2QC1 B;  5AFJ A;  5HEU A;  5AFL A;  2BG9 E;  2Y56 A;  2BG9 B;  2XNU A;  3T4M A;  1I9B A;  4ZR6 A;  4AFH A;  4UM3 P;  2YME A; 
#chains in the Genus database with same CATH topology
 4QH1 A;  5HEH A;  4HFB A;  3C84 A;  3RHW A;  3WIP A;  3LSV A;  2BG9 C;  1UW6 A;  3SQ6 A;  5HCM A;  3SIO A;  5J5G A;  4LML A;  4TNV A;  3C79 A;  2XNT A;  4TWD A;  3UU4 A;  5AFH A;  3U8M A;  3JAF A;  4Z90 A;  4AFG A;  4HFE A;  3U8K A;  5AFM A;  4ILA A;  2XQ3 A;  5SYO A;  5TVC A;  3TLT A;  5AFN A;  3ZKR A;  2BYR A;  2PGZ A;  4LMJ A;  4HFH A;  3UU5 A;  3RIF A;  4NZB A;  4WV9 A;  3U8L A;  2XQ4 A;  4QAB A;  5L4H A;  2W8F A;  2BR8 A;  3WTN A;  2XQ8 A;  2XQ5 A;  4UM1 A;  5KZU A;  4B5D A;  1UX2 A;  3GUA A;  2PH9 A;  3IGQ A;  3WTM A;  4F8H A;  5J5H A;  4QAC A;  3ZDG A;  2Y54 A;  4ILB A;  3WTH A;  3UQ4 A;  3EHZ A;  2XZ6 A;  4ZJS A;  3U8N A;  4Z91 A;  2BG9 A;  3WTJ A;  2XQ7 A;  3TLS A;  4TWH A;  3TLV A;  4AFT A;  4COF A;  2WN9 A;  3EAM A;  2YMD A;  2WNJ A;  4UY2 A;  3WTK A;  2X00 D;  1UV6 A;  5HEJ A;  3SQ9 A;  3UU3 A;  2XZ5 A;  3EI0 A;  5J0Z A;  3PMZ A;  4XK9 A;  3WTL A;  4HFI A;  4QAA A;  2BYP A;  2WNL A;  2Y7Y A;  3JAE A;  3UU6 A;  4NPP A;  3P50 A;  3SH1 A;  2BYN A;  2C9T A;  4ILC A;  4XHE A;  2Y57 A;  5AFM B;  2XQ6 A;  4IL4 A;  3PEO A;  5KE4 A;  5J5F A;  3U8J A;  4BFQ A;  5LG3 A;  4ZZC A;  4A98 A;  4LMK A;  5JME A;  4FRR A;  5BP0 A;  4HQP A;  4IL9 A;  3WTI A;  5HCJ A;  4ZK4 A;  2ZJU A;  4D01 A;  4UM3 A;  4ZJT A;  4TWF A;  2BJ0 A;  3JAD A;  4ZRU A;  4EZ1 A;  5HEG A;  4QH4 A;  5AFK A;  4UM3 S;  2W8G A;  2X00 A;  2BR7 A;  2VL0 A;  2XYT A;  4HFC A;  2Y58 A;  2YKS A;  2YOE A;  3RI5 A;  4A97 A;  3RIA A;  4TNW A;  3TLW A;  4ZZB A;  5L47 A;  4UXU A;  4PIR A;  3RQW A;  5BRX A;  2YN6 A;  5LXB A;  5AIN A;  4BQT A;  3RQU A;  2XYS A;  5CFB A;  2WZY A;  3ZDH A;  2BYQ A;  2XQ9 A;  5FJV A;  5HEO A;  4X5T A;  3TLU A;  2BYS A;  5J5I A;  3UQ7 A;  4DBM A;  5L4E A;  5CO5 A;  4QH5 A;  4ZK1 A;  2XNV A;  5BW2 A;  5IUX A;  2ZJV A;  3UUB A;  3P4W A;  3WTO A;  2XQA A;  2UZ6 A;  4ALX A;  4IRE A;  3UU8 A;  4HFD A;  2WNC A;  2QC1 B;  5AFJ A;  5HEU A;  5AFL A;  2BG9 E;  2Y56 A;  2BG9 B;  2XNU A;  3T4M A;  1I9B A;  4ZR6 A;  4AFH A;  4UM3 P;  2YME A; 
#chains in the Genus database with same CATH homology
 4QH1 A;  5HEH A;  4HFB A;  3C84 A;  3RHW A;  3WIP A;  3LSV A;  2BG9 C;  1UW6 A;  3SQ6 A;  5HCM A;  3SIO A;  5J5G A;  4LML A;  4TNV A;  3C79 A;  2XNT A;  4TWD A;  3UU4 A;  5AFH A;  3U8M A;  3JAF A;  4Z90 A;  4AFG A;  4HFE A;  3U8K A;  5AFM A;  4ILA A;  2XQ3 A;  5SYO A;  5TVC A;  3TLT A;  5AFN A;  3ZKR A;  2BYR A;  2PGZ A;  4LMJ A;  4HFH A;  3UU5 A;  3RIF A;  4NZB A;  4WV9 A;  3U8L A;  2XQ4 A;  4QAB A;  5L4H A;  2W8F A;  2BR8 A;  3WTN A;  2XQ8 A;  2XQ5 A;  4UM1 A;  5KZU A;  4B5D A;  1UX2 A;  3GUA A;  2PH9 A;  3IGQ A;  3WTM A;  4F8H A;  5J5H A;  4QAC A;  3ZDG A;  2Y54 A;  4ILB A;  3WTH A;  3UQ4 A;  3EHZ A;  2XZ6 A;  4ZJS A;  3U8N A;  4Z91 A;  2BG9 A;  3WTJ A;  2XQ7 A;  3TLS A;  4TWH A;  3TLV A;  4AFT A;  4COF A;  2WN9 A;  3EAM A;  2YMD A;  2WNJ A;  4UY2 A;  3WTK A;  2X00 D;  1UV6 A;  5HEJ A;  3SQ9 A;  3UU3 A;  2XZ5 A;  3EI0 A;  5J0Z A;  3PMZ A;  4XK9 A;  3WTL A;  4HFI A;  4QAA A;  2BYP A;  2WNL A;  2Y7Y A;  3JAE A;  3UU6 A;  4NPP A;  3P50 A;  3SH1 A;  2BYN A;  2C9T A;  4ILC A;  4XHE A;  2Y57 A;  5AFM B;  2XQ6 A;  4IL4 A;  3PEO A;  5KE4 A;  5J5F A;  3U8J A;  4BFQ A;  5LG3 A;  4ZZC A;  4A98 A;  4LMK A;  5JME A;  4FRR A;  5BP0 A;  4HQP A;  4IL9 A;  3WTI A;  5HCJ A;  4ZK4 A;  2ZJU A;  4D01 A;  4UM3 A;  4ZJT A;  4TWF A;  2BJ0 A;  3JAD A;  4ZRU A;  4EZ1 A;  5HEG A;  4QH4 A;  5AFK A;  4UM3 S;  2W8G A;  2X00 A;  2BR7 A;  2VL0 A;  2XYT A;  4HFC A;  2Y58 A;  2YKS A;  2YOE A;  3RI5 A;  4A97 A;  3RIA A;  4TNW A;  3TLW A;  4ZZB A;  5L47 A;  4UXU A;  4PIR A;  3RQW A;  5BRX A;  2YN6 A;  5LXB A;  5AIN A;  4BQT A;  3RQU A;  2XYS A;  5CFB A;  2WZY A;  3ZDH A;  2BYQ A;  2XQ9 A;  5FJV A;  5HEO A;  4X5T A;  3TLU A;  2BYS A;  5J5I A;  3UQ7 A;  4DBM A;  5L4E A;  5CO5 A;  4QH5 A;  4ZK1 A;  2XNV A;  5BW2 A;  5IUX A;  2ZJV A;  3UUB A;  3P4W A;  3WTO A;  2XQA A;  2UZ6 A;  4ALX A;  4IRE A;  3UU8 A;  4HFD A;  2WNC A;  2QC1 B;  5AFJ A;  5HEU A;  5AFL A;  2BG9 E;  2Y56 A;  2BG9 B;  2XNU A;  3T4M A;  1I9B A;  4ZR6 A;  4AFH A;  4UM3 P;  2YME A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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5AFMB

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN