5AINA

Varenicline interactions at the 5ht3 receptor ligand binding site are revealed by 5htbp
Total Genus 50
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
50
sequence length
206
structure length
206
Chain Sequence
QANLMRLKSDLFNRSPMYPGPTKDDPLTVTLGFTLQDIVKVDSSTNEVDLVYYERQRWKLNSLMWDPNEYGNITDFRTSAADIWTPDITAYESTRPVQVLSPQIAVVTHDGSVMFIPAQRLSFMCDPTGVDSEEGVTCALTFGSWVYSGFEIDLKTDTDQVDLSSYYASSKYEILSATQTRQVQHYSCCPEPYIDVNLVVKFRERR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Varenicline Interactions at the 5-Ht3 Receptor Ligand Binding Site are Revealed by 5-Htbp.
pubmed doi rcsb
molecule tags Serotonin binding protein
source organism Aplysia californica
molecule keywords SOLUBLE ACETYLCHOLINE RECEPTOR
total genus 50
structure length 206
sequence length 206
chains with identical sequence B, C, D, E
ec nomenclature
pdb deposition date 2015-02-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02931 Neur_chan_LBD Neurotransmitter-gated ion-channel ligand binding domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.170.10 Mainly Beta Distorted Sandwich Acetylcholine Binding Protein; Chain: A, Neurotransmitter-gated ion-channel ligand-binding domain 5ainA00
2Y54A 5CO5A 3WTHA 4LMLA 2WN9A 3UQ4A 5J5GA 3SIOA 5IUXA 3JAFA 3C84A 5LXBA 4UY2A 2XQ9A 4AFHA 2BG9C 2BYPA 2BG9E 2YMDA 4NZBA 3UU8A 2WNCA 5AFNA 2BYNA 3GUAA 3TLSA 4ZK1A 3WTMA 4ZRUA 4IREA 2ZJUA 2X00A 2XYTA 3UU4A 3EHZA 3EAMA 5AFLA 3U8NA 2BG9A 3JADA 5HCJA 5HEUA 4AFGA 2BYQA 5SYOA 3LSVA 2XQAA 3UU6A 3ZKRA 2Y58A 4NPPA 3RQWA 3C79A 2XNVA 4HFCA 4QH5A 4XHEA 2XQ6A 4ZK4A 2BYRA 3WTKA 3ZDGA 5AFMA 5HEJA 2X00D 2XQ8A 2BG9B 5FJVA 3UQ7A 5J5FA 3WTOA 2XNUA 5J5HA 2YKSA 4HFBA 3SQ6A 3U8MA 1UX2A 4AFTA 5HEOA 4HQPA 4ILAA 3PMZA 3RQUA 5AFMB 3TLUA 1UW6A 3UUBA 4UM3S 4ZZBA 3UU3A 4QH1A 3WTLA 2WNLA 2W8GA 5L47A 4BQTA 4UXUA 3WTIA 4X5TA 4ILCA 4DBMA 5BP0A 2XQ5A 2Y56A 3UU5A 5KZUA 1I9BA 4TWFA 2XQ3A 3WTJA 4TNVA 5AFKA 4WV9A 4HFDA 3TLVA 5JMEA 4HFIA 4TNWA 5HCMA 2XYSA 3U8LA 4LMJA 3U8KA 4ZZCA 5AINA 5LG3A 2Y57A 4TWHA 3JAEA 4ZJSA 2ZJVA 5L4HA 5KE4A 2XNTA 4Z90A 4Z91A 5BRXA 3P50A 2YN6A 4ZR6A 5HEHA 4UM1A 3U8JA 2XQ4A 1UV6A 2YMEA 5AFJA 2Y7YA 2QC1B 2WZYA 5TVCA 4BFQA 4PIRA 3SH1A 4LMKA 4QACA 2BR7A 2XZ6A 4HFHA 3PEOA 4B5DA 4A97A 2BR8A 3WTNA 3RHWA 2XZ5A 4QAAA 4QH4A 2VL0A 3WIPA 4D01A 4ZJTA 4ILBA 5HEGA 4FRRA 2YOEA 2PH9A 4IL4A 5BW2A 3EI0A 3RIFA 2UZ6A 4F8HA 2BYSA 2W8FA 4COFA 5L4EA 4QABA 3T4MA 4TWDA 5J0ZA 5AFHA 4UM3A 2PGZA 5CFBA 3ZDHA 4XK9A 3IGQA 3SQ9A 4ALXA 2C9TA 3RI5A 4HFEA 3RIAA 3P4WA 4A98A 2BJ0A 3TLWA 4IL9A 5J5IA 3TLTA 4UM3P 4EZ1A 2XQ7A 2WNJA
chains in the Genus database with same CATH superfamily
2Y54A 5CO5A 3WTHA 4LMLA 2WN9A 3UQ4A 5J5GA 3SIOA 5IUXA 3JAFA 3C84A 5LXBA 4UY2A 2XQ9A 4AFHA 2BG9C 2BYPA 2BG9E 2YMDA 4NZBA 3UU8A 2WNCA 5AFNA 2BYNA 3GUAA 3TLSA 4ZK1A 3WTMA 4ZRUA 4IREA 2ZJUA 2X00A 2XYTA 3UU4A 3EHZA 3EAMA 5AFLA 3U8NA 2BG9A 3JADA 5HCJA 5HEUA 4AFGA 2BYQA 5SYOA 3LSVA 2XQAA 3UU6A 3ZKRA 2Y58A 4NPPA 3RQWA 3C79A 2XNVA 4HFCA 4QH5A 4XHEA 2XQ6A 4ZK4A 2BYRA 3WTKA 3ZDGA 5AFMA 5HEJA 2X00D 2XQ8A 2BG9B 5FJVA 3UQ7A 5J5FA 3WTOA 2XNUA 5J5HA 2YKSA 4HFBA 3SQ6A 3U8MA 1UX2A 4AFTA 5HEOA 4HQPA 4ILAA 3PMZA 3RQUA 5AFMB 3TLUA 1UW6A 3UUBA 4UM3S 4ZZBA 3UU3A 4QH1A 3WTLA 2WNLA 2W8GA 5L47A 4BQTA 4UXUA 3WTIA 4X5TA 4ILCA 4DBMA 5BP0A 2XQ5A 2Y56A 3UU5A 5KZUA 1I9BA 4TWFA 2XQ3A 3WTJA 4TNVA 5AFKA 4WV9A 4HFDA 3TLVA 5JMEA 4HFIA 4TNWA 5HCMA 2XYSA 3U8LA 4LMJA 3U8KA 4ZZCA 5AINA 5LG3A 2Y57A 4TWHA 3JAEA 4ZJSA 2ZJVA 5L4HA 5KE4A 2XNTA 4Z90A 4Z91A 5BRXA 3P50A 2YN6A 4ZR6A 5HEHA 4UM1A 3U8JA 2XQ4A 1UV6A 2YMEA 5AFJA 2Y7YA 2QC1B 2WZYA 5TVCA 4BFQA 4PIRA 3SH1A 4LMKA 4QACA 2BR7A 2XZ6A 4HFHA 3PEOA 4B5DA 4A97A 2BR8A 3WTNA 3RHWA 2XZ5A 4QAAA 4QH4A 2VL0A 3WIPA 4D01A 4ZJTA 4ILBA 5HEGA 4FRRA 2YOEA 2PH9A 4IL4A 5BW2A 3EI0A 3RIFA 2UZ6A 4F8HA 2BYSA 2W8FA 4COFA 5L4EA 4QABA 3T4MA 4TWDA 5J0ZA 5AFHA 4UM3A 2PGZA 5CFBA 3ZDHA 4XK9A 3IGQA 3SQ9A 4ALXA 2C9TA 3RI5A 4HFEA 3RIAA 3P4WA 4A98A 2BJ0A 3TLWA 4IL9A 5J5IA 3TLTA 4UM3P 4EZ1A 2XQ7A 2WNJA
chains in the Genus database with same CATH topology
2Y54A 5CO5A 3WTHA 4LMLA 2WN9A 3UQ4A 5J5GA 3SIOA 5IUXA 3JAFA 3C84A 5LXBA 4UY2A 2XQ9A 4AFHA 2BG9C 2BYPA 2BG9E 2YMDA 4NZBA 3UU8A 2WNCA 5AFNA 2BYNA 3GUAA 3TLSA 4ZK1A 3WTMA 4ZRUA 4IREA 2ZJUA 2X00A 2XYTA 3UU4A 3EHZA 3EAMA 5AFLA 3U8NA 2BG9A 3JADA 5HCJA 5HEUA 4AFGA 2BYQA 5SYOA 3LSVA 2XQAA 3UU6A 3ZKRA 2Y58A 4NPPA 3RQWA 3C79A 2XNVA 4HFCA 4QH5A 4XHEA 2XQ6A 4ZK4A 2BYRA 3WTKA 3ZDGA 5AFMA 5HEJA 2X00D 2XQ8A 2BG9B 5FJVA 3UQ7A 5J5FA 3WTOA 2XNUA 5J5HA 2YKSA 4HFBA 3SQ6A 3U8MA 1UX2A 4AFTA 5HEOA 4HQPA 4ILAA 3PMZA 3RQUA 5AFMB 3TLUA 1UW6A 3UUBA 4UM3S 4ZZBA 3UU3A 4QH1A 3WTLA 2WNLA 2W8GA 5L47A 4BQTA 4UXUA 3WTIA 4X5TA 4ILCA 4DBMA 5BP0A 2XQ5A 2Y56A 3UU5A 5KZUA 1I9BA 4TWFA 2XQ3A 3WTJA 4TNVA 5AFKA 4WV9A 4HFDA 3TLVA 5JMEA 4HFIA 4TNWA 5HCMA 2XYSA 3U8LA 4LMJA 3U8KA 4ZZCA 5AINA 5LG3A 2Y57A 4TWHA 3JAEA 4ZJSA 2ZJVA 5L4HA 5KE4A 2XNTA 4Z90A 4Z91A 5BRXA 3P50A 2YN6A 4ZR6A 5HEHA 4UM1A 3U8JA 2XQ4A 1UV6A 2YMEA 5AFJA 2Y7YA 2QC1B 2WZYA 5TVCA 4BFQA 4PIRA 3SH1A 4LMKA 4QACA 2BR7A 2XZ6A 4HFHA 3PEOA 4B5DA 4A97A 2BR8A 3WTNA 3RHWA 2XZ5A 4QAAA 4QH4A 2VL0A 3WIPA 4D01A 4ZJTA 4ILBA 5HEGA 4FRRA 2YOEA 2PH9A 4IL4A 5BW2A 3EI0A 3RIFA 2UZ6A 4F8HA 2BYSA 2W8FA 4COFA 5L4EA 4QABA 3T4MA 4TWDA 5J0ZA 5AFHA 4UM3A 2PGZA 5CFBA 3ZDHA 4XK9A 3IGQA 3SQ9A 4ALXA 2C9TA 3RI5A 4HFEA 3RIAA 3P4WA 4A98A 2BJ0A 3TLWA 4IL9A 5J5IA 3TLTA 4UM3P 4EZ1A 2XQ7A 2WNJA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2Y54 A;  5CO5 A;  3WTH A;  4LML A;  2WN9 A;  3UQ4 A;  5J5G A;  3SIO A;  5IUX A;  3JAF A;  3C84 A;  5LXB A;  4UY2 A;  2XQ9 A;  4AFH A;  2BG9 C;  2BYP A;  2BG9 E;  2YMD A;  4NZB A;  3UU8 A;  2WNC A;  5AFN A;  2BYN A;  3GUA A;  3TLS A;  4ZK1 A;  3WTM A;  4ZRU A;  4IRE A;  2ZJU A;  2X00 A;  2XYT A;  3UU4 A;  3EHZ A;  3EAM A;  5AFL A;  3U8N A;  2BG9 A;  3JAD A;  5HCJ A;  5HEU A;  4AFG A;  2BYQ A;  5SYO A;  3LSV A;  2XQA A;  3UU6 A;  3ZKR A;  2Y58 A;  4NPP A;  3RQW A;  3C79 A;  2XNV A;  4HFC A;  4QH5 A;  4XHE A;  2XQ6 A;  4ZK4 A;  2BYR A;  3WTK A;  3ZDG A;  5AFM A;  5HEJ A;  2X00 D;  2XQ8 A;  2BG9 B;  5FJV A;  3UQ7 A;  5J5F A;  3WTO A;  2XNU A;  5J5H A;  2YKS A;  4HFB A;  3SQ6 A;  3U8M A;  1UX2 A;  4AFT A;  5HEO A;  4HQP A;  4ILA A;  3PMZ A;  3RQU A;  5AFM B;  3TLU A;  1UW6 A;  3UUB A;  4UM3 S;  4ZZB A;  3UU3 A;  4QH1 A;  3WTL A;  2WNL A;  2W8G A;  5L47 A;  4BQT A;  4UXU A;  3WTI A;  4X5T A;  4ILC A;  4DBM A;  5BP0 A;  2XQ5 A;  2Y56 A;  3UU5 A;  5KZU A;  1I9B A;  4TWF A;  2XQ3 A;  3WTJ A;  4TNV A;  5AFK A;  4WV9 A;  4HFD A;  3TLV A;  5JME A;  4HFI A;  4TNW A;  5HCM A;  2XYS A;  3U8L A;  4LMJ A;  3U8K A;  4ZZC A;  5AIN A;  5LG3 A;  2Y57 A;  4TWH A;  3JAE A;  4ZJS A;  2ZJV A;  5L4H A;  5KE4 A;  2XNT A;  4Z90 A;  4Z91 A;  5BRX A;  3P50 A;  2YN6 A;  4ZR6 A;  5HEH A;  4UM1 A;  3U8J A;  2XQ4 A;  1UV6 A;  2YME A;  5AFJ A;  2Y7Y A;  2QC1 B;  2WZY A;  5TVC A;  4BFQ A;  4PIR A;  3SH1 A;  4LMK A;  4QAC A;  2BR7 A;  2XZ6 A;  4HFH A;  3PEO A;  4B5D A;  4A97 A;  2BR8 A;  3WTN A;  3RHW A;  2XZ5 A;  4QAA A;  4QH4 A;  2VL0 A;  3WIP A;  4D01 A;  4ZJT A;  4ILB A;  5HEG A;  4FRR A;  2YOE A;  2PH9 A;  4IL4 A;  5BW2 A;  3EI0 A;  3RIF A;  2UZ6 A;  4F8H A;  2BYS A;  2W8F A;  4COF A;  5L4E A;  4QAB A;  3T4M A;  4TWD A;  5J0Z A;  5AFH A;  4UM3 A;  2PGZ A;  5CFB A;  3ZDH A;  4XK9 A;  3IGQ A;  3SQ9 A;  4ALX A;  2C9T A;  3RI5 A;  4HFE A;  3RIA A;  3P4W A;  4A98 A;  2BJ0 A;  3TLW A;  4IL9 A;  5J5I A;  3TLT A;  4UM3 P;  4EZ1 A;  2XQ7 A;  2WNJ A; 
#chains in the Genus database with same CATH topology
 2Y54 A;  5CO5 A;  3WTH A;  4LML A;  2WN9 A;  3UQ4 A;  5J5G A;  3SIO A;  5IUX A;  3JAF A;  3C84 A;  5LXB A;  4UY2 A;  2XQ9 A;  4AFH A;  2BG9 C;  2BYP A;  2BG9 E;  2YMD A;  4NZB A;  3UU8 A;  2WNC A;  5AFN A;  2BYN A;  3GUA A;  3TLS A;  4ZK1 A;  3WTM A;  4ZRU A;  4IRE A;  2ZJU A;  2X00 A;  2XYT A;  3UU4 A;  3EHZ A;  3EAM A;  5AFL A;  3U8N A;  2BG9 A;  3JAD A;  5HCJ A;  5HEU A;  4AFG A;  2BYQ A;  5SYO A;  3LSV A;  2XQA A;  3UU6 A;  3ZKR A;  2Y58 A;  4NPP A;  3RQW A;  3C79 A;  2XNV A;  4HFC A;  4QH5 A;  4XHE A;  2XQ6 A;  4ZK4 A;  2BYR A;  3WTK A;  3ZDG A;  5AFM A;  5HEJ A;  2X00 D;  2XQ8 A;  2BG9 B;  5FJV A;  3UQ7 A;  5J5F A;  3WTO A;  2XNU A;  5J5H A;  2YKS A;  4HFB A;  3SQ6 A;  3U8M A;  1UX2 A;  4AFT A;  5HEO A;  4HQP A;  4ILA A;  3PMZ A;  3RQU A;  5AFM B;  3TLU A;  1UW6 A;  3UUB A;  4UM3 S;  4ZZB A;  3UU3 A;  4QH1 A;  3WTL A;  2WNL A;  2W8G A;  5L47 A;  4BQT A;  4UXU A;  3WTI A;  4X5T A;  4ILC A;  4DBM A;  5BP0 A;  2XQ5 A;  2Y56 A;  3UU5 A;  5KZU A;  1I9B A;  4TWF A;  2XQ3 A;  3WTJ A;  4TNV A;  5AFK A;  4WV9 A;  4HFD A;  3TLV A;  5JME A;  4HFI A;  4TNW A;  5HCM A;  2XYS A;  3U8L A;  4LMJ A;  3U8K A;  4ZZC A;  5AIN A;  5LG3 A;  2Y57 A;  4TWH A;  3JAE A;  4ZJS A;  2ZJV A;  5L4H A;  5KE4 A;  2XNT A;  4Z90 A;  4Z91 A;  5BRX A;  3P50 A;  2YN6 A;  4ZR6 A;  5HEH A;  4UM1 A;  3U8J A;  2XQ4 A;  1UV6 A;  2YME A;  5AFJ A;  2Y7Y A;  2QC1 B;  2WZY A;  5TVC A;  4BFQ A;  4PIR A;  3SH1 A;  4LMK A;  4QAC A;  2BR7 A;  2XZ6 A;  4HFH A;  3PEO A;  4B5D A;  4A97 A;  2BR8 A;  3WTN A;  3RHW A;  2XZ5 A;  4QAA A;  4QH4 A;  2VL0 A;  3WIP A;  4D01 A;  4ZJT A;  4ILB A;  5HEG A;  4FRR A;  2YOE A;  2PH9 A;  4IL4 A;  5BW2 A;  3EI0 A;  3RIF A;  2UZ6 A;  4F8H A;  2BYS A;  2W8F A;  4COF A;  5L4E A;  4QAB A;  3T4M A;  4TWD A;  5J0Z A;  5AFH A;  4UM3 A;  2PGZ A;  5CFB A;  3ZDH A;  4XK9 A;  3IGQ A;  3SQ9 A;  4ALX A;  2C9T A;  3RI5 A;  4HFE A;  3RIA A;  3P4W A;  4A98 A;  2BJ0 A;  3TLW A;  4IL9 A;  5J5I A;  3TLT A;  4UM3 P;  4EZ1 A;  2XQ7 A;  2WNJ A; 
#chains in the Genus database with same CATH homology
 2Y54 A;  5CO5 A;  3WTH A;  4LML A;  2WN9 A;  3UQ4 A;  5J5G A;  3SIO A;  5IUX A;  3JAF A;  3C84 A;  5LXB A;  4UY2 A;  2XQ9 A;  4AFH A;  2BG9 C;  2BYP A;  2BG9 E;  2YMD A;  4NZB A;  3UU8 A;  2WNC A;  5AFN A;  2BYN A;  3GUA A;  3TLS A;  4ZK1 A;  3WTM A;  4ZRU A;  4IRE A;  2ZJU A;  2X00 A;  2XYT A;  3UU4 A;  3EHZ A;  3EAM A;  5AFL A;  3U8N A;  2BG9 A;  3JAD A;  5HCJ A;  5HEU A;  4AFG A;  2BYQ A;  5SYO A;  3LSV A;  2XQA A;  3UU6 A;  3ZKR A;  2Y58 A;  4NPP A;  3RQW A;  3C79 A;  2XNV A;  4HFC A;  4QH5 A;  4XHE A;  2XQ6 A;  4ZK4 A;  2BYR A;  3WTK A;  3ZDG A;  5AFM A;  5HEJ A;  2X00 D;  2XQ8 A;  2BG9 B;  5FJV A;  3UQ7 A;  5J5F A;  3WTO A;  2XNU A;  5J5H A;  2YKS A;  4HFB A;  3SQ6 A;  3U8M A;  1UX2 A;  4AFT A;  5HEO A;  4HQP A;  4ILA A;  3PMZ A;  3RQU A;  5AFM B;  3TLU A;  1UW6 A;  3UUB A;  4UM3 S;  4ZZB A;  3UU3 A;  4QH1 A;  3WTL A;  2WNL A;  2W8G A;  5L47 A;  4BQT A;  4UXU A;  3WTI A;  4X5T A;  4ILC A;  4DBM A;  5BP0 A;  2XQ5 A;  2Y56 A;  3UU5 A;  5KZU A;  1I9B A;  4TWF A;  2XQ3 A;  3WTJ A;  4TNV A;  5AFK A;  4WV9 A;  4HFD A;  3TLV A;  5JME A;  4HFI A;  4TNW A;  5HCM A;  2XYS A;  3U8L A;  4LMJ A;  3U8K A;  4ZZC A;  5AIN A;  5LG3 A;  2Y57 A;  4TWH A;  3JAE A;  4ZJS A;  2ZJV A;  5L4H A;  5KE4 A;  2XNT A;  4Z90 A;  4Z91 A;  5BRX A;  3P50 A;  2YN6 A;  4ZR6 A;  5HEH A;  4UM1 A;  3U8J A;  2XQ4 A;  1UV6 A;  2YME A;  5AFJ A;  2Y7Y A;  2QC1 B;  2WZY A;  5TVC A;  4BFQ A;  4PIR A;  3SH1 A;  4LMK A;  4QAC A;  2BR7 A;  2XZ6 A;  4HFH A;  3PEO A;  4B5D A;  4A97 A;  2BR8 A;  3WTN A;  3RHW A;  2XZ5 A;  4QAA A;  4QH4 A;  2VL0 A;  3WIP A;  4D01 A;  4ZJT A;  4ILB A;  5HEG A;  4FRR A;  2YOE A;  2PH9 A;  4IL4 A;  5BW2 A;  3EI0 A;  3RIF A;  2UZ6 A;  4F8H A;  2BYS A;  2W8F A;  4COF A;  5L4E A;  4QAB A;  3T4M A;  4TWD A;  5J0Z A;  5AFH A;  4UM3 A;  2PGZ A;  5CFB A;  3ZDH A;  4XK9 A;  3IGQ A;  3SQ9 A;  4ALX A;  2C9T A;  3RI5 A;  4HFE A;  3RIA A;  3P4W A;  4A98 A;  2BJ0 A;  3TLW A;  4IL9 A;  5J5I A;  3TLT A;  4UM3 P;  4EZ1 A;  2XQ7 A;  2WNJ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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