5AINA

Varenicline interactions at the 5ht3 receptor ligand binding site are revealed by 5htbp
Total Genus 50
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
50
sequence length
206
structure length
206
Chain Sequence
QANLMRLKSDLFNRSPMYPGPTKDDPLTVTLGFTLQDIVKVDSSTNEVDLVYYERQRWKLNSLMWDPNEYGNITDFRTSAADIWTPDITAYESTRPVQVLSPQIAVVTHDGSVMFIPAQRLSFMCDPTGVDSEEGVTCALTFGSWVYSGFEIDLKTDTDQVDLSSYYASSKYEILSATQTRQVQHYSCCPEPYIDVNLVVKFRERR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Varenicline Interactions at the 5-Ht3 Receptor Ligand Binding Site are Revealed by 5-Htbp.
pubmed doi rcsb
molecule tags Serotonin binding protein
source organism Aplysia californica
molecule keywords SOLUBLE ACETYLCHOLINE RECEPTOR
total genus 50
structure length 206
sequence length 206
chains with identical sequence B, C, D, E
ec nomenclature
pdb deposition date 2015-02-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02931 Neur_chan_LBD Neurotransmitter-gated ion-channel ligand binding domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.170.10 Mainly Beta Distorted Sandwich Acetylcholine Binding Protein; Chain: A, Neurotransmitter-gated ion-channel ligand-binding domain 5ainA00
5AFLA 3EHZA 4QH5A 3EAMA 3WTNA 5HEGA 3RI5A 5BP0A 4UXUA 4UM3P 4ZRUA 3RIFA 2BG9B 3TLWA 4TWFA 2WNCA 3JAEA 2XNTA 3RQUA 3UU4A 5KZUA 3IGQA 3ZDHA 5LG3A 5J5IA 3SQ6A 2W8GA 4Z90A 2ZJUA 2BYPA 2XQ7A 2VL0A 2PGZA 3ZDGA 3RQWA 5FJVA 4EZ1A 2WNJA 4QH1A 4QAAA 2BYQA 3TLTA 4LMLA 4ILAA 4WV9A 4DBMA 3U8LA 4TNVA 2W8FA 4UY2A 2XQ4A 4AFGA 4Z91A 4IL9A 4HQPA 3C84A 3U8KA 1UV6A 5L47A 5HEJA 4FRRA 5HEHA 3P50A 4BFQA 3WTHA 2Y7YA 3JAFA 3P4WA 2PH9A 3GUAA 4XHEA 2BG9E 4COFA 2BYRA 2YKSA 3TLUA 4NPPA 2BJ0A 4B5DA 1UW6A 5HCMA 4QH4A 2WN9A 4HFEA 2Y54A 4UM1A 5SYOA 3UU8A 4UM3S 4ZK4A 3PMZA 2BYSA 2XQ3A 4AFTA 2X00D 4F8HA 3UU6A 5TVCA 5J0ZA 2UZ6A 2BG9C 1I9BA 2C9TA 2Y57A 3UU5A 4AFHA 5AINA 4HFBA 3EI0A 2XYSA 2YOEA 4HFHA 4NZBA 3RIAA 3TLVA 2Y58A 3UQ4A 4XK9A 5CFBA 3C79A 3PEOA 5L4EA 4ZZCA 2XNVA 4X5TA 2XZ5A 4TNWA 5HEUA 3U8JA 3U8NA 5BW2A 4ZJSA 4A98A 3UQ7A 4UM3A 3WTJA 5HCJA 5KE4A 2XQ8A 5CO5A 3UU3A 3WIPA 4BQTA 5AFMA 2BYNA 4QACA 4D01A 3WTKA 4ZZBA 5BRXA 3UUBA 2XQ5A 2YMDA 3SH1A 5L4HA 5J5HA 4LMKA 4ILCA 2BR8A 2ZJVA 3T4MA 2XQ6A 4ALXA 5J5FA 2YMEA 4IL4A 4TWDA 2WNLA 2YN6A 2X00A 3WTLA 3SIOA 3LSVA 3JADA 4ZR6A 2XQAA 2XZ6A 4ZK1A 4ILBA 5JMEA 2BG9A 3WTMA 3WTIA 4QABA 3U8MA 3WTOA 3RHWA 5AFNA 3SQ9A 5J5GA 2QC1B 1UX2A 2WZYA 2XQ9A 4PIRA 4HFDA 4TWHA 4HFCA 2XNUA 3TLSA 2XYTA 5AFKA 5AFJA 4A97A 5AFMB 4HFIA 5HEOA 5IUXA 4IREA 2BR7A 4ZJTA 5AFHA 4LMJA 2Y56A 3ZKRA 5LXBA
chains in the Genus database with same CATH superfamily
5AFLA 3EHZA 4QH5A 3EAMA 3WTNA 5HEGA 3RI5A 5BP0A 4UXUA 4UM3P 4ZRUA 3RIFA 2BG9B 3TLWA 4TWFA 2WNCA 3JAEA 2XNTA 3RQUA 3UU4A 5KZUA 3IGQA 3ZDHA 5LG3A 5J5IA 3SQ6A 2W8GA 4Z90A 2ZJUA 2BYPA 2XQ7A 2VL0A 2PGZA 3ZDGA 3RQWA 5FJVA 4EZ1A 2WNJA 4QH1A 4QAAA 2BYQA 3TLTA 4LMLA 4ILAA 4WV9A 4DBMA 3U8LA 4TNVA 2W8FA 4UY2A 2XQ4A 4AFGA 4Z91A 4IL9A 4HQPA 3C84A 3U8KA 1UV6A 5L47A 5HEJA 4FRRA 5HEHA 3P50A 4BFQA 3WTHA 2Y7YA 3JAFA 3P4WA 2PH9A 3GUAA 4XHEA 2BG9E 4COFA 2BYRA 2YKSA 3TLUA 4NPPA 2BJ0A 4B5DA 1UW6A 5HCMA 4QH4A 2WN9A 4HFEA 2Y54A 4UM1A 5SYOA 3UU8A 4UM3S 4ZK4A 3PMZA 2BYSA 2XQ3A 4AFTA 2X00D 4F8HA 3UU6A 5TVCA 5J0ZA 2UZ6A 2BG9C 1I9BA 2C9TA 2Y57A 3UU5A 4AFHA 5AINA 4HFBA 3EI0A 2XYSA 2YOEA 4HFHA 4NZBA 3RIAA 3TLVA 2Y58A 3UQ4A 4XK9A 5CFBA 3C79A 3PEOA 5L4EA 4ZZCA 2XNVA 4X5TA 2XZ5A 4TNWA 5HEUA 3U8JA 3U8NA 5BW2A 4ZJSA 4A98A 3UQ7A 4UM3A 3WTJA 5HCJA 5KE4A 2XQ8A 5CO5A 3UU3A 3WIPA 4BQTA 5AFMA 2BYNA 4QACA 4D01A 3WTKA 4ZZBA 5BRXA 3UUBA 2XQ5A 2YMDA 3SH1A 5L4HA 5J5HA 4LMKA 4ILCA 2BR8A 2ZJVA 3T4MA 2XQ6A 4ALXA 5J5FA 2YMEA 4IL4A 4TWDA 2WNLA 2YN6A 2X00A 3WTLA 3SIOA 3LSVA 3JADA 4ZR6A 2XQAA 2XZ6A 4ZK1A 4ILBA 5JMEA 2BG9A 3WTMA 3WTIA 4QABA 3U8MA 3WTOA 3RHWA 5AFNA 3SQ9A 5J5GA 2QC1B 1UX2A 2WZYA 2XQ9A 4PIRA 4HFDA 4TWHA 4HFCA 2XNUA 3TLSA 2XYTA 5AFKA 5AFJA 4A97A 5AFMB 4HFIA 5HEOA 5IUXA 4IREA 2BR7A 4ZJTA 5AFHA 4LMJA 2Y56A 3ZKRA 5LXBA
chains in the Genus database with same CATH topology
5AFLA 3EHZA 4QH5A 3EAMA 3WTNA 5HEGA 3RI5A 5BP0A 4UXUA 4UM3P 4ZRUA 3RIFA 2BG9B 3TLWA 4TWFA 2WNCA 3JAEA 2XNTA 3RQUA 3UU4A 5KZUA 3IGQA 3ZDHA 5LG3A 5J5IA 3SQ6A 2W8GA 4Z90A 2ZJUA 2BYPA 2XQ7A 2VL0A 2PGZA 3ZDGA 3RQWA 5FJVA 4EZ1A 2WNJA 4QH1A 4QAAA 2BYQA 3TLTA 4LMLA 4ILAA 4WV9A 4DBMA 3U8LA 4TNVA 2W8FA 4UY2A 2XQ4A 4AFGA 4Z91A 4IL9A 4HQPA 3C84A 3U8KA 1UV6A 5L47A 5HEJA 4FRRA 5HEHA 3P50A 4BFQA 3WTHA 2Y7YA 3JAFA 3P4WA 2PH9A 3GUAA 4XHEA 2BG9E 4COFA 2BYRA 2YKSA 3TLUA 4NPPA 2BJ0A 4B5DA 1UW6A 5HCMA 4QH4A 2WN9A 4HFEA 2Y54A 4UM1A 5SYOA 3UU8A 4UM3S 4ZK4A 3PMZA 2BYSA 2XQ3A 4AFTA 2X00D 4F8HA 3UU6A 5TVCA 5J0ZA 2UZ6A 2BG9C 1I9BA 2C9TA 2Y57A 3UU5A 4AFHA 5AINA 4HFBA 3EI0A 2XYSA 2YOEA 4HFHA 4NZBA 3RIAA 3TLVA 2Y58A 3UQ4A 4XK9A 5CFBA 3C79A 3PEOA 5L4EA 4ZZCA 2XNVA 4X5TA 2XZ5A 4TNWA 5HEUA 3U8JA 3U8NA 5BW2A 4ZJSA 4A98A 3UQ7A 4UM3A 3WTJA 5HCJA 5KE4A 2XQ8A 5CO5A 3UU3A 3WIPA 4BQTA 5AFMA 2BYNA 4QACA 4D01A 3WTKA 4ZZBA 5BRXA 3UUBA 2XQ5A 2YMDA 3SH1A 5L4HA 5J5HA 4LMKA 4ILCA 2BR8A 2ZJVA 3T4MA 2XQ6A 4ALXA 5J5FA 2YMEA 4IL4A 4TWDA 2WNLA 2YN6A 2X00A 3WTLA 3SIOA 3LSVA 3JADA 4ZR6A 2XQAA 2XZ6A 4ZK1A 4ILBA 5JMEA 2BG9A 3WTMA 3WTIA 4QABA 3U8MA 3WTOA 3RHWA 5AFNA 3SQ9A 5J5GA 2QC1B 1UX2A 2WZYA 2XQ9A 4PIRA 4HFDA 4TWHA 4HFCA 2XNUA 3TLSA 2XYTA 5AFKA 5AFJA 4A97A 5AFMB 4HFIA 5HEOA 5IUXA 4IREA 2BR7A 4ZJTA 5AFHA 4LMJA 2Y56A 3ZKRA 5LXBA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5AFL A;  3EHZ A;  4QH5 A;  3EAM A;  3WTN A;  5HEG A;  3RI5 A;  5BP0 A;  4UXU A;  4UM3 P;  4ZRU A;  3RIF A;  2BG9 B;  3TLW A;  4TWF A;  2WNC A;  3JAE A;  2XNT A;  3RQU A;  3UU4 A;  5KZU A;  3IGQ A;  3ZDH A;  5LG3 A;  5J5I A;  3SQ6 A;  2W8G A;  4Z90 A;  2ZJU A;  2BYP A;  2XQ7 A;  2VL0 A;  2PGZ A;  3ZDG A;  3RQW A;  5FJV A;  4EZ1 A;  2WNJ A;  4QH1 A;  4QAA A;  2BYQ A;  3TLT A;  4LML A;  4ILA A;  4WV9 A;  4DBM A;  3U8L A;  4TNV A;  2W8F A;  4UY2 A;  2XQ4 A;  4AFG A;  4Z91 A;  4IL9 A;  4HQP A;  3C84 A;  3U8K A;  1UV6 A;  5L47 A;  5HEJ A;  4FRR A;  5HEH A;  3P50 A;  4BFQ A;  3WTH A;  2Y7Y A;  3JAF A;  3P4W A;  2PH9 A;  3GUA A;  4XHE A;  2BG9 E;  4COF A;  2BYR A;  2YKS A;  3TLU A;  4NPP A;  2BJ0 A;  4B5D A;  1UW6 A;  5HCM A;  4QH4 A;  2WN9 A;  4HFE A;  2Y54 A;  4UM1 A;  5SYO A;  3UU8 A;  4UM3 S;  4ZK4 A;  3PMZ A;  2BYS A;  2XQ3 A;  4AFT A;  2X00 D;  4F8H A;  3UU6 A;  5TVC A;  5J0Z A;  2UZ6 A;  2BG9 C;  1I9B A;  2C9T A;  2Y57 A;  3UU5 A;  4AFH A;  5AIN A;  4HFB A;  3EI0 A;  2XYS A;  2YOE A;  4HFH A;  4NZB A;  3RIA A;  3TLV A;  2Y58 A;  3UQ4 A;  4XK9 A;  5CFB A;  3C79 A;  3PEO A;  5L4E A;  4ZZC A;  2XNV A;  4X5T A;  2XZ5 A;  4TNW A;  5HEU A;  3U8J A;  3U8N A;  5BW2 A;  4ZJS A;  4A98 A;  3UQ7 A;  4UM3 A;  3WTJ A;  5HCJ A;  5KE4 A;  2XQ8 A;  5CO5 A;  3UU3 A;  3WIP A;  4BQT A;  5AFM A;  2BYN A;  4QAC A;  4D01 A;  3WTK A;  4ZZB A;  5BRX A;  3UUB A;  2XQ5 A;  2YMD A;  3SH1 A;  5L4H A;  5J5H A;  4LMK A;  4ILC A;  2BR8 A;  2ZJV A;  3T4M A;  2XQ6 A;  4ALX A;  5J5F A;  2YME A;  4IL4 A;  4TWD A;  2WNL A;  2YN6 A;  2X00 A;  3WTL A;  3SIO A;  3LSV A;  3JAD A;  4ZR6 A;  2XQA A;  2XZ6 A;  4ZK1 A;  4ILB A;  5JME A;  2BG9 A;  3WTM A;  3WTI A;  4QAB A;  3U8M A;  3WTO A;  3RHW A;  5AFN A;  3SQ9 A;  5J5G A;  2QC1 B;  1UX2 A;  2WZY A;  2XQ9 A;  4PIR A;  4HFD A;  4TWH A;  4HFC A;  2XNU A;  3TLS A;  2XYT A;  5AFK A;  5AFJ A;  4A97 A;  5AFM B;  4HFI A;  5HEO A;  5IUX A;  4IRE A;  2BR7 A;  4ZJT A;  5AFH A;  4LMJ A;  2Y56 A;  3ZKR A;  5LXB A; 
#chains in the Genus database with same CATH topology
 5AFL A;  3EHZ A;  4QH5 A;  3EAM A;  3WTN A;  5HEG A;  3RI5 A;  5BP0 A;  4UXU A;  4UM3 P;  4ZRU A;  3RIF A;  2BG9 B;  3TLW A;  4TWF A;  2WNC A;  3JAE A;  2XNT A;  3RQU A;  3UU4 A;  5KZU A;  3IGQ A;  3ZDH A;  5LG3 A;  5J5I A;  3SQ6 A;  2W8G A;  4Z90 A;  2ZJU A;  2BYP A;  2XQ7 A;  2VL0 A;  2PGZ A;  3ZDG A;  3RQW A;  5FJV A;  4EZ1 A;  2WNJ A;  4QH1 A;  4QAA A;  2BYQ A;  3TLT A;  4LML A;  4ILA A;  4WV9 A;  4DBM A;  3U8L A;  4TNV A;  2W8F A;  4UY2 A;  2XQ4 A;  4AFG A;  4Z91 A;  4IL9 A;  4HQP A;  3C84 A;  3U8K A;  1UV6 A;  5L47 A;  5HEJ A;  4FRR A;  5HEH A;  3P50 A;  4BFQ A;  3WTH A;  2Y7Y A;  3JAF A;  3P4W A;  2PH9 A;  3GUA A;  4XHE A;  2BG9 E;  4COF A;  2BYR A;  2YKS A;  3TLU A;  4NPP A;  2BJ0 A;  4B5D A;  1UW6 A;  5HCM A;  4QH4 A;  2WN9 A;  4HFE A;  2Y54 A;  4UM1 A;  5SYO A;  3UU8 A;  4UM3 S;  4ZK4 A;  3PMZ A;  2BYS A;  2XQ3 A;  4AFT A;  2X00 D;  4F8H A;  3UU6 A;  5TVC A;  5J0Z A;  2UZ6 A;  2BG9 C;  1I9B A;  2C9T A;  2Y57 A;  3UU5 A;  4AFH A;  5AIN A;  4HFB A;  3EI0 A;  2XYS A;  2YOE A;  4HFH A;  4NZB A;  3RIA A;  3TLV A;  2Y58 A;  3UQ4 A;  4XK9 A;  5CFB A;  3C79 A;  3PEO A;  5L4E A;  4ZZC A;  2XNV A;  4X5T A;  2XZ5 A;  4TNW A;  5HEU A;  3U8J A;  3U8N A;  5BW2 A;  4ZJS A;  4A98 A;  3UQ7 A;  4UM3 A;  3WTJ A;  5HCJ A;  5KE4 A;  2XQ8 A;  5CO5 A;  3UU3 A;  3WIP A;  4BQT A;  5AFM A;  2BYN A;  4QAC A;  4D01 A;  3WTK A;  4ZZB A;  5BRX A;  3UUB A;  2XQ5 A;  2YMD A;  3SH1 A;  5L4H A;  5J5H A;  4LMK A;  4ILC A;  2BR8 A;  2ZJV A;  3T4M A;  2XQ6 A;  4ALX A;  5J5F A;  2YME A;  4IL4 A;  4TWD A;  2WNL A;  2YN6 A;  2X00 A;  3WTL A;  3SIO A;  3LSV A;  3JAD A;  4ZR6 A;  2XQA A;  2XZ6 A;  4ZK1 A;  4ILB A;  5JME A;  2BG9 A;  3WTM A;  3WTI A;  4QAB A;  3U8M A;  3WTO A;  3RHW A;  5AFN A;  3SQ9 A;  5J5G A;  2QC1 B;  1UX2 A;  2WZY A;  2XQ9 A;  4PIR A;  4HFD A;  4TWH A;  4HFC A;  2XNU A;  3TLS A;  2XYT A;  5AFK A;  5AFJ A;  4A97 A;  5AFM B;  4HFI A;  5HEO A;  5IUX A;  4IRE A;  2BR7 A;  4ZJT A;  5AFH A;  4LMJ A;  2Y56 A;  3ZKR A;  5LXB A; 
#chains in the Genus database with same CATH homology
 5AFL A;  3EHZ A;  4QH5 A;  3EAM A;  3WTN A;  5HEG A;  3RI5 A;  5BP0 A;  4UXU A;  4UM3 P;  4ZRU A;  3RIF A;  2BG9 B;  3TLW A;  4TWF A;  2WNC A;  3JAE A;  2XNT A;  3RQU A;  3UU4 A;  5KZU A;  3IGQ A;  3ZDH A;  5LG3 A;  5J5I A;  3SQ6 A;  2W8G A;  4Z90 A;  2ZJU A;  2BYP A;  2XQ7 A;  2VL0 A;  2PGZ A;  3ZDG A;  3RQW A;  5FJV A;  4EZ1 A;  2WNJ A;  4QH1 A;  4QAA A;  2BYQ A;  3TLT A;  4LML A;  4ILA A;  4WV9 A;  4DBM A;  3U8L A;  4TNV A;  2W8F A;  4UY2 A;  2XQ4 A;  4AFG A;  4Z91 A;  4IL9 A;  4HQP A;  3C84 A;  3U8K A;  1UV6 A;  5L47 A;  5HEJ A;  4FRR A;  5HEH A;  3P50 A;  4BFQ A;  3WTH A;  2Y7Y A;  3JAF A;  3P4W A;  2PH9 A;  3GUA A;  4XHE A;  2BG9 E;  4COF A;  2BYR A;  2YKS A;  3TLU A;  4NPP A;  2BJ0 A;  4B5D A;  1UW6 A;  5HCM A;  4QH4 A;  2WN9 A;  4HFE A;  2Y54 A;  4UM1 A;  5SYO A;  3UU8 A;  4UM3 S;  4ZK4 A;  3PMZ A;  2BYS A;  2XQ3 A;  4AFT A;  2X00 D;  4F8H A;  3UU6 A;  5TVC A;  5J0Z A;  2UZ6 A;  2BG9 C;  1I9B A;  2C9T A;  2Y57 A;  3UU5 A;  4AFH A;  5AIN A;  4HFB A;  3EI0 A;  2XYS A;  2YOE A;  4HFH A;  4NZB A;  3RIA A;  3TLV A;  2Y58 A;  3UQ4 A;  4XK9 A;  5CFB A;  3C79 A;  3PEO A;  5L4E A;  4ZZC A;  2XNV A;  4X5T A;  2XZ5 A;  4TNW A;  5HEU A;  3U8J A;  3U8N A;  5BW2 A;  4ZJS A;  4A98 A;  3UQ7 A;  4UM3 A;  3WTJ A;  5HCJ A;  5KE4 A;  2XQ8 A;  5CO5 A;  3UU3 A;  3WIP A;  4BQT A;  5AFM A;  2BYN A;  4QAC A;  4D01 A;  3WTK A;  4ZZB A;  5BRX A;  3UUB A;  2XQ5 A;  2YMD A;  3SH1 A;  5L4H A;  5J5H A;  4LMK A;  4ILC A;  2BR8 A;  2ZJV A;  3T4M A;  2XQ6 A;  4ALX A;  5J5F A;  2YME A;  4IL4 A;  4TWD A;  2WNL A;  2YN6 A;  2X00 A;  3WTL A;  3SIO A;  3LSV A;  3JAD A;  4ZR6 A;  2XQA A;  2XZ6 A;  4ZK1 A;  4ILB A;  5JME A;  2BG9 A;  3WTM A;  3WTI A;  4QAB A;  3U8M A;  3WTO A;  3RHW A;  5AFN A;  3SQ9 A;  5J5G A;  2QC1 B;  1UX2 A;  2WZY A;  2XQ9 A;  4PIR A;  4HFD A;  4TWH A;  4HFC A;  2XNU A;  3TLS A;  2XYT A;  5AFK A;  5AFJ A;  4A97 A;  5AFM B;  4HFI A;  5HEO A;  5IUX A;  4IRE A;  2BR7 A;  4ZJT A;  5AFH A;  4LMJ A;  2Y56 A;  3ZKR A;  5LXB A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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