5BRXA

X-ray crystal structure of aplysia californica (ac-achbp) in complex with 2-pyridyl azatricyclo[3.3.1.13,7]decane; 2-pyridylazaadamantane; 2-aza (ti-8480)
Total Genus 48
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
48
sequence length
211
structure length
209
Chain Sequence
DDKLHSQANLMRLKSDLFNRSYPGPTKDDPLTVTLGFTLQDIVKADSSTNEVDLVYWEQQRWKLNSLMWDPNEYGNITDFRTSAADIWTPDITAYSSTRPVQVLSPQIAVVTHDGSVMFIPAQRLSFMCDPTGVDSEEGATCAVKFGSWVYSGFEIDLKTDTDQVDLSSYYASSKYEILSATQTRQVQHYSCCPEPYIDVNLVVKFRER
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Comparisons of Binding Affinities for Neuronal Nicotinic Receptors (NNRs) and AChBPs
rcsb
molecule tags Acetylcholine binding protein
source organism Aplysia californica
molecule keywords Soluble acetylcholine receptor
total genus 48
structure length 209
sequence length 211
chains with identical sequence B, C, D, E, F, G, H, I, J
ec nomenclature
pdb deposition date 2015-06-01

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02931 Neur_chan_LBD Neurotransmitter-gated ion-channel ligand binding domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.170.10 Mainly Beta Distorted Sandwich Acetylcholine Binding Protein; Chain: A, Neurotransmitter-gated ion-channel ligand-binding domain 5brxA00
4IL4A 3U8KA 4QH5A 4XHEA 2ZJUA 2Y54A 2PH9A 4HFHA 5HEHA 4UM1A 3TLSA 2ZJVA 1I9BA 4ZZBA 3ZDGA 4A97A 5L47A 2BYNA 2BG9B 3SIOA 3RIAA 3P50A 4HFBA 3UQ4A 2XNUA 4COFA 5CFBA 2XZ6A 3LSVA 4TWDA 3WTKA 3JAFA 5HEOA 4TNWA 3WTMA 4QH4A 4DBMA 4HQPA 3UU5A 3UU8A 2XQ8A 4Z90A 3JAEA 2W8GA 2XQ9A 4UY2A 4ZR6A 5AFLA 2XZ5A 3RI5A 4ZJSA 3C79A 2QC1B 3UU4A 4ILAA 5J5HA 4TNVA 4HFEA 3RQWA 3RQUA 2X00D 3WTLA 5HCMA 3WTOA 2BR7A 4AFTA 5AFJA 4IL9A 4LMJA 4AFGA 5HEJA 2X00A 4IREA 2YMEA 4NZBA 3EAMA 3UUBA 3WTIA 5J5FA 5FJVA 3WTNA 4WV9A 2XQ3A 4QABA 3GUAA 4F8HA 3C84A 2VL0A 4LMKA 4HFCA 2Y57A 2BYPA 2XNTA 4HFDA 2WNLA 3WIPA 5LG3A 4TWHA 4ZJTA 5AFMA 2YN6A 4ILCA 4NPPA 2BG9E 4QH1A 4UM3P 4ALXA 4PIRA 3RHWA 4ILBA 4UM3S 1UV6A 2WNJA 4UXUA 4EZ1A 5BW2A 3UQ7A 5LXBA 5HEGA 3SH1A 4Z91A 3U8JA 2PGZA 3RIFA 3T4MA 3UU3A 2XQ5A 2BG9A 5J5IA 1UX2A 2UZ6A 5HEUA 2XYTA 5SYOA 4BQTA 3EHZA 4ZK1A 4LMLA 3ZDHA 3TLTA 2WZYA 3P4WA 4D01A 3U8LA 3U8NA 3JADA 4XK9A 2XQ7A 5AINA 5BRXA 5BP0A 2XYSA 4X5TA 3PEOA 2YKSA 2WN9A 4UM3A 5J5GA 3TLVA 2Y56A 3UU6A 1UW6A 5AFKA 5JMEA 5KZUA 3WTHA 4FRRA 5AFMB 3PMZA 2XQAA 5KE4A 2BG9C 2Y7YA 2BYRA 4QACA 3EI0A 4ZK4A 3WTJA 5IUXA 2Y58A 3IGQA 5L4HA 2BJ0A 4A98A 2XNVA 5AFHA 5AFNA 4QAAA 2YOEA 3ZKRA 4ZRUA 4AFHA 3SQ9A 4B5DA 3TLUA 2BR8A 2YMDA 3TLWA 4HFIA 2BYSA 4BFQA 3U8MA 3SQ6A 5L4EA 5TVCA 2XQ6A 5J0ZA 2WNCA 2W8FA 4TWFA 4ZZCA 2BYQA 5HCJA 5CO5A 2XQ4A 2C9TA
chains in the Genus database with same CATH superfamily
4IL4A 3U8KA 4QH5A 4XHEA 2ZJUA 2Y54A 2PH9A 4HFHA 5HEHA 4UM1A 3TLSA 2ZJVA 1I9BA 4ZZBA 3ZDGA 4A97A 5L47A 2BYNA 2BG9B 3SIOA 3RIAA 3P50A 4HFBA 3UQ4A 2XNUA 4COFA 5CFBA 2XZ6A 3LSVA 4TWDA 3WTKA 3JAFA 5HEOA 4TNWA 3WTMA 4QH4A 4DBMA 4HQPA 3UU5A 3UU8A 2XQ8A 4Z90A 3JAEA 2W8GA 2XQ9A 4UY2A 4ZR6A 5AFLA 2XZ5A 3RI5A 4ZJSA 3C79A 2QC1B 3UU4A 4ILAA 5J5HA 4TNVA 4HFEA 3RQWA 3RQUA 2X00D 3WTLA 5HCMA 3WTOA 2BR7A 4AFTA 5AFJA 4IL9A 4LMJA 4AFGA 5HEJA 2X00A 4IREA 2YMEA 4NZBA 3EAMA 3UUBA 3WTIA 5J5FA 5FJVA 3WTNA 4WV9A 2XQ3A 4QABA 3GUAA 4F8HA 3C84A 2VL0A 4LMKA 4HFCA 2Y57A 2BYPA 2XNTA 4HFDA 2WNLA 3WIPA 5LG3A 4TWHA 4ZJTA 5AFMA 2YN6A 4ILCA 4NPPA 2BG9E 4QH1A 4UM3P 4ALXA 4PIRA 3RHWA 4ILBA 4UM3S 1UV6A 2WNJA 4UXUA 4EZ1A 5BW2A 3UQ7A 5LXBA 5HEGA 3SH1A 4Z91A 3U8JA 2PGZA 3RIFA 3T4MA 3UU3A 2XQ5A 2BG9A 5J5IA 1UX2A 2UZ6A 5HEUA 2XYTA 5SYOA 4BQTA 3EHZA 4ZK1A 4LMLA 3ZDHA 3TLTA 2WZYA 3P4WA 4D01A 3U8LA 3U8NA 3JADA 4XK9A 2XQ7A 5AINA 5BRXA 5BP0A 2XYSA 4X5TA 3PEOA 2YKSA 2WN9A 4UM3A 5J5GA 3TLVA 2Y56A 3UU6A 1UW6A 5AFKA 5JMEA 5KZUA 3WTHA 4FRRA 5AFMB 3PMZA 2XQAA 5KE4A 2BG9C 2Y7YA 2BYRA 4QACA 3EI0A 4ZK4A 3WTJA 5IUXA 2Y58A 3IGQA 5L4HA 2BJ0A 4A98A 2XNVA 5AFHA 5AFNA 4QAAA 2YOEA 3ZKRA 4ZRUA 4AFHA 3SQ9A 4B5DA 3TLUA 2BR8A 2YMDA 3TLWA 4HFIA 2BYSA 4BFQA 3U8MA 3SQ6A 5L4EA 5TVCA 2XQ6A 5J0ZA 2WNCA 2W8FA 4TWFA 4ZZCA 2BYQA 5HCJA 5CO5A 2XQ4A 2C9TA
chains in the Genus database with same CATH topology
4IL4A 3U8KA 4QH5A 4XHEA 2ZJUA 2Y54A 2PH9A 4HFHA 5HEHA 4UM1A 3TLSA 2ZJVA 1I9BA 4ZZBA 3ZDGA 4A97A 5L47A 2BYNA 2BG9B 3SIOA 3RIAA 3P50A 4HFBA 3UQ4A 2XNUA 4COFA 5CFBA 2XZ6A 3LSVA 4TWDA 3WTKA 3JAFA 5HEOA 4TNWA 3WTMA 4QH4A 4DBMA 4HQPA 3UU5A 3UU8A 2XQ8A 4Z90A 3JAEA 2W8GA 2XQ9A 4UY2A 4ZR6A 5AFLA 2XZ5A 3RI5A 4ZJSA 3C79A 2QC1B 3UU4A 4ILAA 5J5HA 4TNVA 4HFEA 3RQWA 3RQUA 2X00D 3WTLA 5HCMA 3WTOA 2BR7A 4AFTA 5AFJA 4IL9A 4LMJA 4AFGA 5HEJA 2X00A 4IREA 2YMEA 4NZBA 3EAMA 3UUBA 3WTIA 5J5FA 5FJVA 3WTNA 4WV9A 2XQ3A 4QABA 3GUAA 4F8HA 3C84A 2VL0A 4LMKA 4HFCA 2Y57A 2BYPA 2XNTA 4HFDA 2WNLA 3WIPA 5LG3A 4TWHA 4ZJTA 5AFMA 2YN6A 4ILCA 4NPPA 2BG9E 4QH1A 4UM3P 4ALXA 4PIRA 3RHWA 4ILBA 4UM3S 1UV6A 2WNJA 4UXUA 4EZ1A 5BW2A 3UQ7A 5LXBA 5HEGA 3SH1A 4Z91A 3U8JA 2PGZA 3RIFA 3T4MA 3UU3A 2XQ5A 2BG9A 5J5IA 1UX2A 2UZ6A 5HEUA 2XYTA 5SYOA 4BQTA 3EHZA 4ZK1A 4LMLA 3ZDHA 3TLTA 2WZYA 3P4WA 4D01A 3U8LA 3U8NA 3JADA 4XK9A 2XQ7A 5AINA 5BRXA 5BP0A 2XYSA 4X5TA 3PEOA 2YKSA 2WN9A 4UM3A 5J5GA 3TLVA 2Y56A 3UU6A 1UW6A 5AFKA 5JMEA 5KZUA 3WTHA 4FRRA 5AFMB 3PMZA 2XQAA 5KE4A 2BG9C 2Y7YA 2BYRA 4QACA 3EI0A 4ZK4A 3WTJA 5IUXA 2Y58A 3IGQA 5L4HA 2BJ0A 4A98A 2XNVA 5AFHA 5AFNA 4QAAA 2YOEA 3ZKRA 4ZRUA 4AFHA 3SQ9A 4B5DA 3TLUA 2BR8A 2YMDA 3TLWA 4HFIA 2BYSA 4BFQA 3U8MA 3SQ6A 5L4EA 5TVCA 2XQ6A 5J0ZA 2WNCA 2W8FA 4TWFA 4ZZCA 2BYQA 5HCJA 5CO5A 2XQ4A 2C9TA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4IL4 A;  3U8K A;  4QH5 A;  4XHE A;  2ZJU A;  2Y54 A;  2PH9 A;  4HFH A;  5HEH A;  4UM1 A;  3TLS A;  2ZJV A;  1I9B A;  4ZZB A;  3ZDG A;  4A97 A;  5L47 A;  2BYN A;  2BG9 B;  3SIO A;  3RIA A;  3P50 A;  4HFB A;  3UQ4 A;  2XNU A;  4COF A;  5CFB A;  2XZ6 A;  3LSV A;  4TWD A;  3WTK A;  3JAF A;  5HEO A;  4TNW A;  3WTM A;  4QH4 A;  4DBM A;  4HQP A;  3UU5 A;  3UU8 A;  2XQ8 A;  4Z90 A;  3JAE A;  2W8G A;  2XQ9 A;  4UY2 A;  4ZR6 A;  5AFL A;  2XZ5 A;  3RI5 A;  4ZJS A;  3C79 A;  2QC1 B;  3UU4 A;  4ILA A;  5J5H A;  4TNV A;  4HFE A;  3RQW A;  3RQU A;  2X00 D;  3WTL A;  5HCM A;  3WTO A;  2BR7 A;  4AFT A;  5AFJ A;  4IL9 A;  4LMJ A;  4AFG A;  5HEJ A;  2X00 A;  4IRE A;  2YME A;  4NZB A;  3EAM A;  3UUB A;  3WTI A;  5J5F A;  5FJV A;  3WTN A;  4WV9 A;  2XQ3 A;  4QAB A;  3GUA A;  4F8H A;  3C84 A;  2VL0 A;  4LMK A;  4HFC A;  2Y57 A;  2BYP A;  2XNT A;  4HFD A;  2WNL A;  3WIP A;  5LG3 A;  4TWH A;  4ZJT A;  5AFM A;  2YN6 A;  4ILC A;  4NPP A;  2BG9 E;  4QH1 A;  4UM3 P;  4ALX A;  4PIR A;  3RHW A;  4ILB A;  4UM3 S;  1UV6 A;  2WNJ A;  4UXU A;  4EZ1 A;  5BW2 A;  3UQ7 A;  5LXB A;  5HEG A;  3SH1 A;  4Z91 A;  3U8J A;  2PGZ A;  3RIF A;  3T4M A;  3UU3 A;  2XQ5 A;  2BG9 A;  5J5I A;  1UX2 A;  2UZ6 A;  5HEU A;  2XYT A;  5SYO A;  4BQT A;  3EHZ A;  4ZK1 A;  4LML A;  3ZDH A;  3TLT A;  2WZY A;  3P4W A;  4D01 A;  3U8L A;  3U8N A;  3JAD A;  4XK9 A;  2XQ7 A;  5AIN A;  5BRX A;  5BP0 A;  2XYS A;  4X5T A;  3PEO A;  2YKS A;  2WN9 A;  4UM3 A;  5J5G A;  3TLV A;  2Y56 A;  3UU6 A;  1UW6 A;  5AFK A;  5JME A;  5KZU A;  3WTH A;  4FRR A;  5AFM B;  3PMZ A;  2XQA A;  5KE4 A;  2BG9 C;  2Y7Y A;  2BYR A;  4QAC A;  3EI0 A;  4ZK4 A;  3WTJ A;  5IUX A;  2Y58 A;  3IGQ A;  5L4H A;  2BJ0 A;  4A98 A;  2XNV A;  5AFH A;  5AFN A;  4QAA A;  2YOE A;  3ZKR A;  4ZRU A;  4AFH A;  3SQ9 A;  4B5D A;  3TLU A;  2BR8 A;  2YMD A;  3TLW A;  4HFI A;  2BYS A;  4BFQ A;  3U8M A;  3SQ6 A;  5L4E A;  5TVC A;  2XQ6 A;  5J0Z A;  2WNC A;  2W8F A;  4TWF A;  4ZZC A;  2BYQ A;  5HCJ A;  5CO5 A;  2XQ4 A;  2C9T A; 
#chains in the Genus database with same CATH topology
 4IL4 A;  3U8K A;  4QH5 A;  4XHE A;  2ZJU A;  2Y54 A;  2PH9 A;  4HFH A;  5HEH A;  4UM1 A;  3TLS A;  2ZJV A;  1I9B A;  4ZZB A;  3ZDG A;  4A97 A;  5L47 A;  2BYN A;  2BG9 B;  3SIO A;  3RIA A;  3P50 A;  4HFB A;  3UQ4 A;  2XNU A;  4COF A;  5CFB A;  2XZ6 A;  3LSV A;  4TWD A;  3WTK A;  3JAF A;  5HEO A;  4TNW A;  3WTM A;  4QH4 A;  4DBM A;  4HQP A;  3UU5 A;  3UU8 A;  2XQ8 A;  4Z90 A;  3JAE A;  2W8G A;  2XQ9 A;  4UY2 A;  4ZR6 A;  5AFL A;  2XZ5 A;  3RI5 A;  4ZJS A;  3C79 A;  2QC1 B;  3UU4 A;  4ILA A;  5J5H A;  4TNV A;  4HFE A;  3RQW A;  3RQU A;  2X00 D;  3WTL A;  5HCM A;  3WTO A;  2BR7 A;  4AFT A;  5AFJ A;  4IL9 A;  4LMJ A;  4AFG A;  5HEJ A;  2X00 A;  4IRE A;  2YME A;  4NZB A;  3EAM A;  3UUB A;  3WTI A;  5J5F A;  5FJV A;  3WTN A;  4WV9 A;  2XQ3 A;  4QAB A;  3GUA A;  4F8H A;  3C84 A;  2VL0 A;  4LMK A;  4HFC A;  2Y57 A;  2BYP A;  2XNT A;  4HFD A;  2WNL A;  3WIP A;  5LG3 A;  4TWH A;  4ZJT A;  5AFM A;  2YN6 A;  4ILC A;  4NPP A;  2BG9 E;  4QH1 A;  4UM3 P;  4ALX A;  4PIR A;  3RHW A;  4ILB A;  4UM3 S;  1UV6 A;  2WNJ A;  4UXU A;  4EZ1 A;  5BW2 A;  3UQ7 A;  5LXB A;  5HEG A;  3SH1 A;  4Z91 A;  3U8J A;  2PGZ A;  3RIF A;  3T4M A;  3UU3 A;  2XQ5 A;  2BG9 A;  5J5I A;  1UX2 A;  2UZ6 A;  5HEU A;  2XYT A;  5SYO A;  4BQT A;  3EHZ A;  4ZK1 A;  4LML A;  3ZDH A;  3TLT A;  2WZY A;  3P4W A;  4D01 A;  3U8L A;  3U8N A;  3JAD A;  4XK9 A;  2XQ7 A;  5AIN A;  5BRX A;  5BP0 A;  2XYS A;  4X5T A;  3PEO A;  2YKS A;  2WN9 A;  4UM3 A;  5J5G A;  3TLV A;  2Y56 A;  3UU6 A;  1UW6 A;  5AFK A;  5JME A;  5KZU A;  3WTH A;  4FRR A;  5AFM B;  3PMZ A;  2XQA A;  5KE4 A;  2BG9 C;  2Y7Y A;  2BYR A;  4QAC A;  3EI0 A;  4ZK4 A;  3WTJ A;  5IUX A;  2Y58 A;  3IGQ A;  5L4H A;  2BJ0 A;  4A98 A;  2XNV A;  5AFH A;  5AFN A;  4QAA A;  2YOE A;  3ZKR A;  4ZRU A;  4AFH A;  3SQ9 A;  4B5D A;  3TLU A;  2BR8 A;  2YMD A;  3TLW A;  4HFI A;  2BYS A;  4BFQ A;  3U8M A;  3SQ6 A;  5L4E A;  5TVC A;  2XQ6 A;  5J0Z A;  2WNC A;  2W8F A;  4TWF A;  4ZZC A;  2BYQ A;  5HCJ A;  5CO5 A;  2XQ4 A;  2C9T A; 
#chains in the Genus database with same CATH homology
 4IL4 A;  3U8K A;  4QH5 A;  4XHE A;  2ZJU A;  2Y54 A;  2PH9 A;  4HFH A;  5HEH A;  4UM1 A;  3TLS A;  2ZJV A;  1I9B A;  4ZZB A;  3ZDG A;  4A97 A;  5L47 A;  2BYN A;  2BG9 B;  3SIO A;  3RIA A;  3P50 A;  4HFB A;  3UQ4 A;  2XNU A;  4COF A;  5CFB A;  2XZ6 A;  3LSV A;  4TWD A;  3WTK A;  3JAF A;  5HEO A;  4TNW A;  3WTM A;  4QH4 A;  4DBM A;  4HQP A;  3UU5 A;  3UU8 A;  2XQ8 A;  4Z90 A;  3JAE A;  2W8G A;  2XQ9 A;  4UY2 A;  4ZR6 A;  5AFL A;  2XZ5 A;  3RI5 A;  4ZJS A;  3C79 A;  2QC1 B;  3UU4 A;  4ILA A;  5J5H A;  4TNV A;  4HFE A;  3RQW A;  3RQU A;  2X00 D;  3WTL A;  5HCM A;  3WTO A;  2BR7 A;  4AFT A;  5AFJ A;  4IL9 A;  4LMJ A;  4AFG A;  5HEJ A;  2X00 A;  4IRE A;  2YME A;  4NZB A;  3EAM A;  3UUB A;  3WTI A;  5J5F A;  5FJV A;  3WTN A;  4WV9 A;  2XQ3 A;  4QAB A;  3GUA A;  4F8H A;  3C84 A;  2VL0 A;  4LMK A;  4HFC A;  2Y57 A;  2BYP A;  2XNT A;  4HFD A;  2WNL A;  3WIP A;  5LG3 A;  4TWH A;  4ZJT A;  5AFM A;  2YN6 A;  4ILC A;  4NPP A;  2BG9 E;  4QH1 A;  4UM3 P;  4ALX A;  4PIR A;  3RHW A;  4ILB A;  4UM3 S;  1UV6 A;  2WNJ A;  4UXU A;  4EZ1 A;  5BW2 A;  3UQ7 A;  5LXB A;  5HEG A;  3SH1 A;  4Z91 A;  3U8J A;  2PGZ A;  3RIF A;  3T4M A;  3UU3 A;  2XQ5 A;  2BG9 A;  5J5I A;  1UX2 A;  2UZ6 A;  5HEU A;  2XYT A;  5SYO A;  4BQT A;  3EHZ A;  4ZK1 A;  4LML A;  3ZDH A;  3TLT A;  2WZY A;  3P4W A;  4D01 A;  3U8L A;  3U8N A;  3JAD A;  4XK9 A;  2XQ7 A;  5AIN A;  5BRX A;  5BP0 A;  2XYS A;  4X5T A;  3PEO A;  2YKS A;  2WN9 A;  4UM3 A;  5J5G A;  3TLV A;  2Y56 A;  3UU6 A;  1UW6 A;  5AFK A;  5JME A;  5KZU A;  3WTH A;  4FRR A;  5AFM B;  3PMZ A;  2XQA A;  5KE4 A;  2BG9 C;  2Y7Y A;  2BYR A;  4QAC A;  3EI0 A;  4ZK4 A;  3WTJ A;  5IUX A;  2Y58 A;  3IGQ A;  5L4H A;  2BJ0 A;  4A98 A;  2XNV A;  5AFH A;  5AFN A;  4QAA A;  2YOE A;  3ZKR A;  4ZRU A;  4AFH A;  3SQ9 A;  4B5D A;  3TLU A;  2BR8 A;  2YMD A;  3TLW A;  4HFI A;  2BYS A;  4BFQ A;  3U8M A;  3SQ6 A;  5L4E A;  5TVC A;  2XQ6 A;  5J0Z A;  2WNC A;  2W8F A;  4TWF A;  4ZZC A;  2BYQ A;  5HCJ A;  5CO5 A;  2XQ4 A;  2C9T A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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