5BW2A

X-ray crystal structure of aplysia californica acetylcholine binding protein (ac-achbp) y55w in complex with 2-pyridin-3-yl-1-aza-bicyclo[2.2.2]octane; 2-(3-pyridyl)quinuclidine; 2-pq (ti-4699)
Total Genus 52
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
52
sequence length
212
structure length
211
Chain Sequence
DKLHSQANLMRLKSDLFNRSMYPGPTKDDPLTVTLGFTLQDIVKADSSTNEVDLVYWEQQRWKLNSLMWDPNEYGNITDFRTSAADIWTPDITAYSSTRPVQVLSPQIAVVTHDGSVMFIPAQRLSFMCDPTGVDSEEGATCAVKFGSWVYSGFEIDLKTDTDQVDLSSYYASSKYEILSATQTRQVQHYSCCPEPYIDVNLVVKFRERRA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Comparisons of Binding Affinities for Neuronal Nicotinic Receptors (NNRs) and AChBPs
rcsb
molecule tags Acetylcholine binding protein
source organism Aplysia californica
molecule keywords Soluble acetylcholine receptor
total genus 52
structure length 211
sequence length 212
chains with identical sequence B, C, D, E
ec nomenclature
pdb deposition date 2015-06-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02931 Neur_chan_LBD Neurotransmitter-gated ion-channel ligand binding domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.170.10 Mainly Beta Distorted Sandwich Acetylcholine Binding Protein; Chain: A, Neurotransmitter-gated ion-channel ligand-binding domain 5bw2A00
4ZJTA 4IREA 2VL0A 4XHEA 4QH5A 3TLVA 2XYSA 4BQTA 2YMEA 5HCMA 3WTHA 5L4HA 3GUAA 4TNWA 3JADA 5AFKA 2BYPA 2XYTA 4ILCA 3SQ9A 4AFHA 2YN6A 4QABA 4XK9A 2XQ3A 2XQ4A 4HQPA 4B5DA 4A98A 5SYOA 4HFBA 5J0ZA 4ILBA 4HFIA 5AFLA 5BRXA 3IGQA 4ZK1A 4UM1A 3UU4A 2XZ5A 3UU5A 5AFNA 5AFJA 3P4WA 2C9TA 5CO5A 2WNCA 2WZYA 3C79A 4UXUA 2PGZA 3UU8A 3RI5A 3U8KA 4COFA 4DBMA 4ZRUA 5J5GA 4Z91A 3SQ6A 5J5IA 2X00D 5HEUA 2Y54A 5AINA 4HFDA 3TLSA 5J5HA 4ZR6A 5FJVA 4QH4A 5HEHA 3U8JA 4ALXA 3UQ7A 4LMLA 4HFCA 4HFHA 4LMJA 4IL4A 4UM3S 3PMZA 2YKSA 2WNLA 4NZBA 2XQAA 3WTJA 5LXBA 4QACA 4ZJSA 4PIRA 4NPPA 5AFMA 5JMEA 3SH1A 3U8LA 2XNTA 4EZ1A 3UQ4A 5L4EA 2BG9E 3T4MA 3LSVA 4HFEA 3SIOA 3U8NA 3JAEA 1UX2A 3P50A 2XNUA 2Y58A 3WTKA 3WTOA 5CFBA 5HCJA 2QC1B 3WTMA 5BP0A 2PH9A 2XQ9A 2WNJA 5IUXA 3TLWA 4LMKA 4ZK4A 4F8HA 2XQ7A 4QAAA 2XQ8A 5AFMB 3RQWA 3TLTA 2XNVA 2YMDA 4TNVA 3WTNA 3TLUA 4FRRA 3ZDGA 4WV9A 4BFQA 3U8MA 1UV6A 2BYSA 2W8GA 2BG9C 3RIFA 2XQ6A 3JAFA 4ZZBA 1I9BA 4QH1A 5KZUA 2YOEA 5HEGA 5HEOA 3WTIA 2BG9A 3UU3A 4ILAA 2BYNA 2WN9A 3WIPA 2BR7A 4D01A 3C84A 5TVCA 4Z90A 3UU6A 3UUBA 3WTLA 2ZJVA 2Y7YA 4AFTA 2Y57A 2UZ6A 2BYRA 5HEJA 2XZ6A 2ZJUA 4TWHA 5LG3A 5L47A 2BYQA 1UW6A 3RQUA 2W8FA 3EI0A 2BR8A 4UM3A 5AFHA 2Y56A 5BW2A 4A97A 2BG9B 3PEOA 4TWDA 5KE4A 2BJ0A 2XQ5A 5J5FA 2X00A 3RHWA 3ZKRA 4AFGA 4ZZCA 4UM3P 4IL9A 4X5TA 4TWFA 3EHZA 3EAMA 4UY2A 3RIAA 3ZDHA
chains in the Genus database with same CATH superfamily
4ZJTA 4IREA 2VL0A 4XHEA 4QH5A 3TLVA 2XYSA 4BQTA 2YMEA 5HCMA 3WTHA 5L4HA 3GUAA 4TNWA 3JADA 5AFKA 2BYPA 2XYTA 4ILCA 3SQ9A 4AFHA 2YN6A 4QABA 4XK9A 2XQ3A 2XQ4A 4HQPA 4B5DA 4A98A 5SYOA 4HFBA 5J0ZA 4ILBA 4HFIA 5AFLA 5BRXA 3IGQA 4ZK1A 4UM1A 3UU4A 2XZ5A 3UU5A 5AFNA 5AFJA 3P4WA 2C9TA 5CO5A 2WNCA 2WZYA 3C79A 4UXUA 2PGZA 3UU8A 3RI5A 3U8KA 4COFA 4DBMA 4ZRUA 5J5GA 4Z91A 3SQ6A 5J5IA 2X00D 5HEUA 2Y54A 5AINA 4HFDA 3TLSA 5J5HA 4ZR6A 5FJVA 4QH4A 5HEHA 3U8JA 4ALXA 3UQ7A 4LMLA 4HFCA 4HFHA 4LMJA 4IL4A 4UM3S 3PMZA 2YKSA 2WNLA 4NZBA 2XQAA 3WTJA 5LXBA 4QACA 4ZJSA 4PIRA 4NPPA 5AFMA 5JMEA 3SH1A 3U8LA 2XNTA 4EZ1A 3UQ4A 5L4EA 2BG9E 3T4MA 3LSVA 4HFEA 3SIOA 3U8NA 3JAEA 1UX2A 3P50A 2XNUA 2Y58A 3WTKA 3WTOA 5CFBA 5HCJA 2QC1B 3WTMA 5BP0A 2PH9A 2XQ9A 2WNJA 5IUXA 3TLWA 4LMKA 4ZK4A 4F8HA 2XQ7A 4QAAA 2XQ8A 5AFMB 3RQWA 3TLTA 2XNVA 2YMDA 4TNVA 3WTNA 3TLUA 4FRRA 3ZDGA 4WV9A 4BFQA 3U8MA 1UV6A 2BYSA 2W8GA 2BG9C 3RIFA 2XQ6A 3JAFA 4ZZBA 1I9BA 4QH1A 5KZUA 2YOEA 5HEGA 5HEOA 3WTIA 2BG9A 3UU3A 4ILAA 2BYNA 2WN9A 3WIPA 2BR7A 4D01A 3C84A 5TVCA 4Z90A 3UU6A 3UUBA 3WTLA 2ZJVA 2Y7YA 4AFTA 2Y57A 2UZ6A 2BYRA 5HEJA 2XZ6A 2ZJUA 4TWHA 5LG3A 5L47A 2BYQA 1UW6A 3RQUA 2W8FA 3EI0A 2BR8A 4UM3A 5AFHA 2Y56A 5BW2A 4A97A 2BG9B 3PEOA 4TWDA 5KE4A 2BJ0A 2XQ5A 5J5FA 2X00A 3RHWA 3ZKRA 4AFGA 4ZZCA 4UM3P 4IL9A 4X5TA 4TWFA 3EHZA 3EAMA 4UY2A 3RIAA 3ZDHA
chains in the Genus database with same CATH topology
4ZJTA 4IREA 2VL0A 4XHEA 4QH5A 3TLVA 2XYSA 4BQTA 2YMEA 5HCMA 3WTHA 5L4HA 3GUAA 4TNWA 3JADA 5AFKA 2BYPA 2XYTA 4ILCA 3SQ9A 4AFHA 2YN6A 4QABA 4XK9A 2XQ3A 2XQ4A 4HQPA 4B5DA 4A98A 5SYOA 4HFBA 5J0ZA 4ILBA 4HFIA 5AFLA 5BRXA 3IGQA 4ZK1A 4UM1A 3UU4A 2XZ5A 3UU5A 5AFNA 5AFJA 3P4WA 2C9TA 5CO5A 2WNCA 2WZYA 3C79A 4UXUA 2PGZA 3UU8A 3RI5A 3U8KA 4COFA 4DBMA 4ZRUA 5J5GA 4Z91A 3SQ6A 5J5IA 2X00D 5HEUA 2Y54A 5AINA 4HFDA 3TLSA 5J5HA 4ZR6A 5FJVA 4QH4A 5HEHA 3U8JA 4ALXA 3UQ7A 4LMLA 4HFCA 4HFHA 4LMJA 4IL4A 4UM3S 3PMZA 2YKSA 2WNLA 4NZBA 2XQAA 3WTJA 5LXBA 4QACA 4ZJSA 4PIRA 4NPPA 5AFMA 5JMEA 3SH1A 3U8LA 2XNTA 4EZ1A 3UQ4A 5L4EA 2BG9E 3T4MA 3LSVA 4HFEA 3SIOA 3U8NA 3JAEA 1UX2A 3P50A 2XNUA 2Y58A 3WTKA 3WTOA 5CFBA 5HCJA 2QC1B 3WTMA 5BP0A 2PH9A 2XQ9A 2WNJA 5IUXA 3TLWA 4LMKA 4ZK4A 4F8HA 2XQ7A 4QAAA 2XQ8A 5AFMB 3RQWA 3TLTA 2XNVA 2YMDA 4TNVA 3WTNA 3TLUA 4FRRA 3ZDGA 4WV9A 4BFQA 3U8MA 1UV6A 2BYSA 2W8GA 2BG9C 3RIFA 2XQ6A 3JAFA 4ZZBA 1I9BA 4QH1A 5KZUA 2YOEA 5HEGA 5HEOA 3WTIA 2BG9A 3UU3A 4ILAA 2BYNA 2WN9A 3WIPA 2BR7A 4D01A 3C84A 5TVCA 4Z90A 3UU6A 3UUBA 3WTLA 2ZJVA 2Y7YA 4AFTA 2Y57A 2UZ6A 2BYRA 5HEJA 2XZ6A 2ZJUA 4TWHA 5LG3A 5L47A 2BYQA 1UW6A 3RQUA 2W8FA 3EI0A 2BR8A 4UM3A 5AFHA 2Y56A 5BW2A 4A97A 2BG9B 3PEOA 4TWDA 5KE4A 2BJ0A 2XQ5A 5J5FA 2X00A 3RHWA 3ZKRA 4AFGA 4ZZCA 4UM3P 4IL9A 4X5TA 4TWFA 3EHZA 3EAMA 4UY2A 3RIAA 3ZDHA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4ZJT A;  4IRE A;  2VL0 A;  4XHE A;  4QH5 A;  3TLV A;  2XYS A;  4BQT A;  2YME A;  5HCM A;  3WTH A;  5L4H A;  3GUA A;  4TNW A;  3JAD A;  5AFK A;  2BYP A;  2XYT A;  4ILC A;  3SQ9 A;  4AFH A;  2YN6 A;  4QAB A;  4XK9 A;  2XQ3 A;  2XQ4 A;  4HQP A;  4B5D A;  4A98 A;  5SYO A;  4HFB A;  5J0Z A;  4ILB A;  4HFI A;  5AFL A;  5BRX A;  3IGQ A;  4ZK1 A;  4UM1 A;  3UU4 A;  2XZ5 A;  3UU5 A;  5AFN A;  5AFJ A;  3P4W A;  2C9T A;  5CO5 A;  2WNC A;  2WZY A;  3C79 A;  4UXU A;  2PGZ A;  3UU8 A;  3RI5 A;  3U8K A;  4COF A;  4DBM A;  4ZRU A;  5J5G A;  4Z91 A;  3SQ6 A;  5J5I A;  2X00 D;  5HEU A;  2Y54 A;  5AIN A;  4HFD A;  3TLS A;  5J5H A;  4ZR6 A;  5FJV A;  4QH4 A;  5HEH A;  3U8J A;  4ALX A;  3UQ7 A;  4LML A;  4HFC A;  4HFH A;  4LMJ A;  4IL4 A;  4UM3 S;  3PMZ A;  2YKS A;  2WNL A;  4NZB A;  2XQA A;  3WTJ A;  5LXB A;  4QAC A;  4ZJS A;  4PIR A;  4NPP A;  5AFM A;  5JME A;  3SH1 A;  3U8L A;  2XNT A;  4EZ1 A;  3UQ4 A;  5L4E A;  2BG9 E;  3T4M A;  3LSV A;  4HFE A;  3SIO A;  3U8N A;  3JAE A;  1UX2 A;  3P50 A;  2XNU A;  2Y58 A;  3WTK A;  3WTO A;  5CFB A;  5HCJ A;  2QC1 B;  3WTM A;  5BP0 A;  2PH9 A;  2XQ9 A;  2WNJ A;  5IUX A;  3TLW A;  4LMK A;  4ZK4 A;  4F8H A;  2XQ7 A;  4QAA A;  2XQ8 A;  5AFM B;  3RQW A;  3TLT A;  2XNV A;  2YMD A;  4TNV A;  3WTN A;  3TLU A;  4FRR A;  3ZDG A;  4WV9 A;  4BFQ A;  3U8M A;  1UV6 A;  2BYS A;  2W8G A;  2BG9 C;  3RIF A;  2XQ6 A;  3JAF A;  4ZZB A;  1I9B A;  4QH1 A;  5KZU A;  2YOE A;  5HEG A;  5HEO A;  3WTI A;  2BG9 A;  3UU3 A;  4ILA A;  2BYN A;  2WN9 A;  3WIP A;  2BR7 A;  4D01 A;  3C84 A;  5TVC A;  4Z90 A;  3UU6 A;  3UUB A;  3WTL A;  2ZJV A;  2Y7Y A;  4AFT A;  2Y57 A;  2UZ6 A;  2BYR A;  5HEJ A;  2XZ6 A;  2ZJU A;  4TWH A;  5LG3 A;  5L47 A;  2BYQ A;  1UW6 A;  3RQU A;  2W8F A;  3EI0 A;  2BR8 A;  4UM3 A;  5AFH A;  2Y56 A;  5BW2 A;  4A97 A;  2BG9 B;  3PEO A;  4TWD A;  5KE4 A;  2BJ0 A;  2XQ5 A;  5J5F A;  2X00 A;  3RHW A;  3ZKR A;  4AFG A;  4ZZC A;  4UM3 P;  4IL9 A;  4X5T A;  4TWF A;  3EHZ A;  3EAM A;  4UY2 A;  3RIA A;  3ZDH A; 
#chains in the Genus database with same CATH topology
 4ZJT A;  4IRE A;  2VL0 A;  4XHE A;  4QH5 A;  3TLV A;  2XYS A;  4BQT A;  2YME A;  5HCM A;  3WTH A;  5L4H A;  3GUA A;  4TNW A;  3JAD A;  5AFK A;  2BYP A;  2XYT A;  4ILC A;  3SQ9 A;  4AFH A;  2YN6 A;  4QAB A;  4XK9 A;  2XQ3 A;  2XQ4 A;  4HQP A;  4B5D A;  4A98 A;  5SYO A;  4HFB A;  5J0Z A;  4ILB A;  4HFI A;  5AFL A;  5BRX A;  3IGQ A;  4ZK1 A;  4UM1 A;  3UU4 A;  2XZ5 A;  3UU5 A;  5AFN A;  5AFJ A;  3P4W A;  2C9T A;  5CO5 A;  2WNC A;  2WZY A;  3C79 A;  4UXU A;  2PGZ A;  3UU8 A;  3RI5 A;  3U8K A;  4COF A;  4DBM A;  4ZRU A;  5J5G A;  4Z91 A;  3SQ6 A;  5J5I A;  2X00 D;  5HEU A;  2Y54 A;  5AIN A;  4HFD A;  3TLS A;  5J5H A;  4ZR6 A;  5FJV A;  4QH4 A;  5HEH A;  3U8J A;  4ALX A;  3UQ7 A;  4LML A;  4HFC A;  4HFH A;  4LMJ A;  4IL4 A;  4UM3 S;  3PMZ A;  2YKS A;  2WNL A;  4NZB A;  2XQA A;  3WTJ A;  5LXB A;  4QAC A;  4ZJS A;  4PIR A;  4NPP A;  5AFM A;  5JME A;  3SH1 A;  3U8L A;  2XNT A;  4EZ1 A;  3UQ4 A;  5L4E A;  2BG9 E;  3T4M A;  3LSV A;  4HFE A;  3SIO A;  3U8N A;  3JAE A;  1UX2 A;  3P50 A;  2XNU A;  2Y58 A;  3WTK A;  3WTO A;  5CFB A;  5HCJ A;  2QC1 B;  3WTM A;  5BP0 A;  2PH9 A;  2XQ9 A;  2WNJ A;  5IUX A;  3TLW A;  4LMK A;  4ZK4 A;  4F8H A;  2XQ7 A;  4QAA A;  2XQ8 A;  5AFM B;  3RQW A;  3TLT A;  2XNV A;  2YMD A;  4TNV A;  3WTN A;  3TLU A;  4FRR A;  3ZDG A;  4WV9 A;  4BFQ A;  3U8M A;  1UV6 A;  2BYS A;  2W8G A;  2BG9 C;  3RIF A;  2XQ6 A;  3JAF A;  4ZZB A;  1I9B A;  4QH1 A;  5KZU A;  2YOE A;  5HEG A;  5HEO A;  3WTI A;  2BG9 A;  3UU3 A;  4ILA A;  2BYN A;  2WN9 A;  3WIP A;  2BR7 A;  4D01 A;  3C84 A;  5TVC A;  4Z90 A;  3UU6 A;  3UUB A;  3WTL A;  2ZJV A;  2Y7Y A;  4AFT A;  2Y57 A;  2UZ6 A;  2BYR A;  5HEJ A;  2XZ6 A;  2ZJU A;  4TWH A;  5LG3 A;  5L47 A;  2BYQ A;  1UW6 A;  3RQU A;  2W8F A;  3EI0 A;  2BR8 A;  4UM3 A;  5AFH A;  2Y56 A;  5BW2 A;  4A97 A;  2BG9 B;  3PEO A;  4TWD A;  5KE4 A;  2BJ0 A;  2XQ5 A;  5J5F A;  2X00 A;  3RHW A;  3ZKR A;  4AFG A;  4ZZC A;  4UM3 P;  4IL9 A;  4X5T A;  4TWF A;  3EHZ A;  3EAM A;  4UY2 A;  3RIA A;  3ZDH A; 
#chains in the Genus database with same CATH homology
 4ZJT A;  4IRE A;  2VL0 A;  4XHE A;  4QH5 A;  3TLV A;  2XYS A;  4BQT A;  2YME A;  5HCM A;  3WTH A;  5L4H A;  3GUA A;  4TNW A;  3JAD A;  5AFK A;  2BYP A;  2XYT A;  4ILC A;  3SQ9 A;  4AFH A;  2YN6 A;  4QAB A;  4XK9 A;  2XQ3 A;  2XQ4 A;  4HQP A;  4B5D A;  4A98 A;  5SYO A;  4HFB A;  5J0Z A;  4ILB A;  4HFI A;  5AFL A;  5BRX A;  3IGQ A;  4ZK1 A;  4UM1 A;  3UU4 A;  2XZ5 A;  3UU5 A;  5AFN A;  5AFJ A;  3P4W A;  2C9T A;  5CO5 A;  2WNC A;  2WZY A;  3C79 A;  4UXU A;  2PGZ A;  3UU8 A;  3RI5 A;  3U8K A;  4COF A;  4DBM A;  4ZRU A;  5J5G A;  4Z91 A;  3SQ6 A;  5J5I A;  2X00 D;  5HEU A;  2Y54 A;  5AIN A;  4HFD A;  3TLS A;  5J5H A;  4ZR6 A;  5FJV A;  4QH4 A;  5HEH A;  3U8J A;  4ALX A;  3UQ7 A;  4LML A;  4HFC A;  4HFH A;  4LMJ A;  4IL4 A;  4UM3 S;  3PMZ A;  2YKS A;  2WNL A;  4NZB A;  2XQA A;  3WTJ A;  5LXB A;  4QAC A;  4ZJS A;  4PIR A;  4NPP A;  5AFM A;  5JME A;  3SH1 A;  3U8L A;  2XNT A;  4EZ1 A;  3UQ4 A;  5L4E A;  2BG9 E;  3T4M A;  3LSV A;  4HFE A;  3SIO A;  3U8N A;  3JAE A;  1UX2 A;  3P50 A;  2XNU A;  2Y58 A;  3WTK A;  3WTO A;  5CFB A;  5HCJ A;  2QC1 B;  3WTM A;  5BP0 A;  2PH9 A;  2XQ9 A;  2WNJ A;  5IUX A;  3TLW A;  4LMK A;  4ZK4 A;  4F8H A;  2XQ7 A;  4QAA A;  2XQ8 A;  5AFM B;  3RQW A;  3TLT A;  2XNV A;  2YMD A;  4TNV A;  3WTN A;  3TLU A;  4FRR A;  3ZDG A;  4WV9 A;  4BFQ A;  3U8M A;  1UV6 A;  2BYS A;  2W8G A;  2BG9 C;  3RIF A;  2XQ6 A;  3JAF A;  4ZZB A;  1I9B A;  4QH1 A;  5KZU A;  2YOE A;  5HEG A;  5HEO A;  3WTI A;  2BG9 A;  3UU3 A;  4ILA A;  2BYN A;  2WN9 A;  3WIP A;  2BR7 A;  4D01 A;  3C84 A;  5TVC A;  4Z90 A;  3UU6 A;  3UUB A;  3WTL A;  2ZJV A;  2Y7Y A;  4AFT A;  2Y57 A;  2UZ6 A;  2BYR A;  5HEJ A;  2XZ6 A;  2ZJU A;  4TWH A;  5LG3 A;  5L47 A;  2BYQ A;  1UW6 A;  3RQU A;  2W8F A;  3EI0 A;  2BR8 A;  4UM3 A;  5AFH A;  2Y56 A;  5BW2 A;  4A97 A;  2BG9 B;  3PEO A;  4TWD A;  5KE4 A;  2BJ0 A;  2XQ5 A;  5J5F A;  2X00 A;  3RHW A;  3ZKR A;  4AFG A;  4ZZC A;  4UM3 P;  4IL9 A;  4X5T A;  4TWF A;  3EHZ A;  3EAM A;  4UY2 A;  3RIA A;  3ZDH A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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