5FJVA

Crystal structure of the extracellular domain of alpha2 nicotinic acetylcholine receptor in pentameric assembly
Total Genus 35
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
35
sequence length
206
structure length
206
Chain Sequence
DRLFKHLFRGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWSDYKLRWNPTDFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVPPAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDLKDYWESGEWAIVNATGTYNSKKYDCCAEIYPDVTYAFVIRRLP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structure of a Human Neuronal Nachr Extracellular Domain in Pentameric Assembly: Ligand-Bound Alpah2 Homopentamer.
pubmed doi rcsb
molecule tags Acetylcholine-binding protein
source organism Homo sapiens
molecule keywords NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-2
total genus 35
structure length 206
sequence length 206
chains with identical sequence B, C, D, E
ec nomenclature
pdb deposition date 2015-10-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02931 Neur_chan_LBD Neurotransmitter-gated ion-channel ligand binding domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.170.10 Mainly Beta Distorted Sandwich Acetylcholine Binding Protein; Chain: A, Neurotransmitter-gated ion-channel ligand-binding domain 5fjvA00
3TLVA 3WTMA 3RI5A 2YMEA 3C79A 4IL9A 4Z91A 4IREA 3UU4A 5TVCA 3C84A 4HFCA 4EZ1A 3RIAA 5LXBA 2Y57A 5AFKA 2YN6A 5AFJA 3RHWA 2BR7A 2XQ6A 3ZDHA 2XQ4A 4UY2A 4TWDA 4QH1A 3UU8A 4ZZBA 5J5IA 3JAFA 4QAAA 5HEOA 4ILBA 1UX2A 2X00A 4QACA 2XZ5A 3U8LA 4B5DA 2XNVA 3RIFA 2WNJA 3RQUA 3PEOA 2YMDA 5IUXA 4FRRA 4BFQA 3LSVA 3UU3A 2BR8A 4ILCA 4ZK4A 2WNLA 4X5TA 5HEGA 5L4EA 4ZJSA 3EHZA 5FJVA 4TNVA 4IL4A 2BJ0A 5CO5A 2WNCA 2XYSA 1UV6A 4QH4A 4LMKA 4UM1A 2ZJUA 5L4HA 5J5GA 5SYOA 4D01A 2VL0A 2XQ3A 5AFMA 3WTKA 2BG9A 5AFHA 1I9BA 3SQ9A 3WTOA 4BQTA 4NPPA 4TWFA 2UZ6A 2BYQA 5AFLA 3TLTA 2BG9C 3U8MA 4ILAA 4COFA 2XQ8A 2XQAA 3UQ4A 2XNUA 3ZDGA 4A97A 5KE4A 2BYNA 2YKSA 3U8KA 5KZUA 3GUAA 2C9TA 2BG9B 4HQPA 4ALXA 2XNTA 4HFBA 3WTLA 5HEHA 4DBMA 5BW2A 5AFNA 5J0ZA 1UW6A 4WV9A 2BYRA 5HCMA 5HCJA 4ZRUA 2Y56A 2XQ9A 3UQ7A 4XK9A 5JMEA 3U8JA 5BRXA 4HFHA 2W8GA 4ZJTA 2PH9A 3WIPA 2BG9E 2XYTA 4UM3S 2BYPA 4HFEA 4PIRA 2XQ5A 3SIOA 3UU6A 5HEUA 4ZK1A 4UM3P 5BP0A 4HFIA 4AFTA 3TLSA 4XHEA 5AINA 3JAEA 3WTHA 4Z90A 5AFMB 3IGQA 3T4MA 3EI0A 3ZKRA 5CFBA 2X00D 3JADA 3U8NA 2WN9A 3WTJA 2QC1B 4AFHA 4AFGA 2Y7YA 3P50A 4ZR6A 3PMZA 2PGZA 2YOEA 3TLWA 4TNWA 4HFDA 4LMLA 2XQ7A 3RQWA 3P4WA 4ZZCA 2WZYA 5LG3A 2W8FA 5L47A 3SH1A 3UU5A 3SQ6A 3WTIA 3UUBA 4QABA 4LMJA 4UXUA 4F8HA 4QH5A 5HEJA 4TWHA 5J5FA 5J5HA 3EAMA 3WTNA 4NZBA 2BYSA 2Y58A 2Y54A 4UM3A 2ZJVA 4A98A 2XZ6A 3TLUA
chains in the Genus database with same CATH superfamily
3TLVA 3WTMA 3RI5A 2YMEA 3C79A 4IL9A 4Z91A 4IREA 3UU4A 5TVCA 3C84A 4HFCA 4EZ1A 3RIAA 5LXBA 2Y57A 5AFKA 2YN6A 5AFJA 3RHWA 2BR7A 2XQ6A 3ZDHA 2XQ4A 4UY2A 4TWDA 4QH1A 3UU8A 4ZZBA 5J5IA 3JAFA 4QAAA 5HEOA 4ILBA 1UX2A 2X00A 4QACA 2XZ5A 3U8LA 4B5DA 2XNVA 3RIFA 2WNJA 3RQUA 3PEOA 2YMDA 5IUXA 4FRRA 4BFQA 3LSVA 3UU3A 2BR8A 4ILCA 4ZK4A 2WNLA 4X5TA 5HEGA 5L4EA 4ZJSA 3EHZA 5FJVA 4TNVA 4IL4A 2BJ0A 5CO5A 2WNCA 2XYSA 1UV6A 4QH4A 4LMKA 4UM1A 2ZJUA 5L4HA 5J5GA 5SYOA 4D01A 2VL0A 2XQ3A 5AFMA 3WTKA 2BG9A 5AFHA 1I9BA 3SQ9A 3WTOA 4BQTA 4NPPA 4TWFA 2UZ6A 2BYQA 5AFLA 3TLTA 2BG9C 3U8MA 4ILAA 4COFA 2XQ8A 2XQAA 3UQ4A 2XNUA 3ZDGA 4A97A 5KE4A 2BYNA 2YKSA 3U8KA 5KZUA 3GUAA 2C9TA 2BG9B 4HQPA 4ALXA 2XNTA 4HFBA 3WTLA 5HEHA 4DBMA 5BW2A 5AFNA 5J0ZA 1UW6A 4WV9A 2BYRA 5HCMA 5HCJA 4ZRUA 2Y56A 2XQ9A 3UQ7A 4XK9A 5JMEA 3U8JA 5BRXA 4HFHA 2W8GA 4ZJTA 2PH9A 3WIPA 2BG9E 2XYTA 4UM3S 2BYPA 4HFEA 4PIRA 2XQ5A 3SIOA 3UU6A 5HEUA 4ZK1A 4UM3P 5BP0A 4HFIA 4AFTA 3TLSA 4XHEA 5AINA 3JAEA 3WTHA 4Z90A 5AFMB 3IGQA 3T4MA 3EI0A 3ZKRA 5CFBA 2X00D 3JADA 3U8NA 2WN9A 3WTJA 2QC1B 4AFHA 4AFGA 2Y7YA 3P50A 4ZR6A 3PMZA 2PGZA 2YOEA 3TLWA 4TNWA 4HFDA 4LMLA 2XQ7A 3RQWA 3P4WA 4ZZCA 2WZYA 5LG3A 2W8FA 5L47A 3SH1A 3UU5A 3SQ6A 3WTIA 3UUBA 4QABA 4LMJA 4UXUA 4F8HA 4QH5A 5HEJA 4TWHA 5J5FA 5J5HA 3EAMA 3WTNA 4NZBA 2BYSA 2Y58A 2Y54A 4UM3A 2ZJVA 4A98A 2XZ6A 3TLUA
chains in the Genus database with same CATH topology
3TLVA 3WTMA 3RI5A 2YMEA 3C79A 4IL9A 4Z91A 4IREA 3UU4A 5TVCA 3C84A 4HFCA 4EZ1A 3RIAA 5LXBA 2Y57A 5AFKA 2YN6A 5AFJA 3RHWA 2BR7A 2XQ6A 3ZDHA 2XQ4A 4UY2A 4TWDA 4QH1A 3UU8A 4ZZBA 5J5IA 3JAFA 4QAAA 5HEOA 4ILBA 1UX2A 2X00A 4QACA 2XZ5A 3U8LA 4B5DA 2XNVA 3RIFA 2WNJA 3RQUA 3PEOA 2YMDA 5IUXA 4FRRA 4BFQA 3LSVA 3UU3A 2BR8A 4ILCA 4ZK4A 2WNLA 4X5TA 5HEGA 5L4EA 4ZJSA 3EHZA 5FJVA 4TNVA 4IL4A 2BJ0A 5CO5A 2WNCA 2XYSA 1UV6A 4QH4A 4LMKA 4UM1A 2ZJUA 5L4HA 5J5GA 5SYOA 4D01A 2VL0A 2XQ3A 5AFMA 3WTKA 2BG9A 5AFHA 1I9BA 3SQ9A 3WTOA 4BQTA 4NPPA 4TWFA 2UZ6A 2BYQA 5AFLA 3TLTA 2BG9C 3U8MA 4ILAA 4COFA 2XQ8A 2XQAA 3UQ4A 2XNUA 3ZDGA 4A97A 5KE4A 2BYNA 2YKSA 3U8KA 5KZUA 3GUAA 2C9TA 2BG9B 4HQPA 4ALXA 2XNTA 4HFBA 3WTLA 5HEHA 4DBMA 5BW2A 5AFNA 5J0ZA 1UW6A 4WV9A 2BYRA 5HCMA 5HCJA 4ZRUA 2Y56A 2XQ9A 3UQ7A 4XK9A 5JMEA 3U8JA 5BRXA 4HFHA 2W8GA 4ZJTA 2PH9A 3WIPA 2BG9E 2XYTA 4UM3S 2BYPA 4HFEA 4PIRA 2XQ5A 3SIOA 3UU6A 5HEUA 4ZK1A 4UM3P 5BP0A 4HFIA 4AFTA 3TLSA 4XHEA 5AINA 3JAEA 3WTHA 4Z90A 5AFMB 3IGQA 3T4MA 3EI0A 3ZKRA 5CFBA 2X00D 3JADA 3U8NA 2WN9A 3WTJA 2QC1B 4AFHA 4AFGA 2Y7YA 3P50A 4ZR6A 3PMZA 2PGZA 2YOEA 3TLWA 4TNWA 4HFDA 4LMLA 2XQ7A 3RQWA 3P4WA 4ZZCA 2WZYA 5LG3A 2W8FA 5L47A 3SH1A 3UU5A 3SQ6A 3WTIA 3UUBA 4QABA 4LMJA 4UXUA 4F8HA 4QH5A 5HEJA 4TWHA 5J5FA 5J5HA 3EAMA 3WTNA 4NZBA 2BYSA 2Y58A 2Y54A 4UM3A 2ZJVA 4A98A 2XZ6A 3TLUA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3TLV A;  3WTM A;  3RI5 A;  2YME A;  3C79 A;  4IL9 A;  4Z91 A;  4IRE A;  3UU4 A;  5TVC A;  3C84 A;  4HFC A;  4EZ1 A;  3RIA A;  5LXB A;  2Y57 A;  5AFK A;  2YN6 A;  5AFJ A;  3RHW A;  2BR7 A;  2XQ6 A;  3ZDH A;  2XQ4 A;  4UY2 A;  4TWD A;  4QH1 A;  3UU8 A;  4ZZB A;  5J5I A;  3JAF A;  4QAA A;  5HEO A;  4ILB A;  1UX2 A;  2X00 A;  4QAC A;  2XZ5 A;  3U8L A;  4B5D A;  2XNV A;  3RIF A;  2WNJ A;  3RQU A;  3PEO A;  2YMD A;  5IUX A;  4FRR A;  4BFQ A;  3LSV A;  3UU3 A;  2BR8 A;  4ILC A;  4ZK4 A;  2WNL A;  4X5T A;  5HEG A;  5L4E A;  4ZJS A;  3EHZ A;  5FJV A;  4TNV A;  4IL4 A;  2BJ0 A;  5CO5 A;  2WNC A;  2XYS A;  1UV6 A;  4QH4 A;  4LMK A;  4UM1 A;  2ZJU A;  5L4H A;  5J5G A;  5SYO A;  4D01 A;  2VL0 A;  2XQ3 A;  5AFM A;  3WTK A;  2BG9 A;  5AFH A;  1I9B A;  3SQ9 A;  3WTO A;  4BQT A;  4NPP A;  4TWF A;  2UZ6 A;  2BYQ A;  5AFL A;  3TLT A;  2BG9 C;  3U8M A;  4ILA A;  4COF A;  2XQ8 A;  2XQA A;  3UQ4 A;  2XNU A;  3ZDG A;  4A97 A;  5KE4 A;  2BYN A;  2YKS A;  3U8K A;  5KZU A;  3GUA A;  2C9T A;  2BG9 B;  4HQP A;  4ALX A;  2XNT A;  4HFB A;  3WTL A;  5HEH A;  4DBM A;  5BW2 A;  5AFN A;  5J0Z A;  1UW6 A;  4WV9 A;  2BYR A;  5HCM A;  5HCJ A;  4ZRU A;  2Y56 A;  2XQ9 A;  3UQ7 A;  4XK9 A;  5JME A;  3U8J A;  5BRX A;  4HFH A;  2W8G A;  4ZJT A;  2PH9 A;  3WIP A;  2BG9 E;  2XYT A;  4UM3 S;  2BYP A;  4HFE A;  4PIR A;  2XQ5 A;  3SIO A;  3UU6 A;  5HEU A;  4ZK1 A;  4UM3 P;  5BP0 A;  4HFI A;  4AFT A;  3TLS A;  4XHE A;  5AIN A;  3JAE A;  3WTH A;  4Z90 A;  5AFM B;  3IGQ A;  3T4M A;  3EI0 A;  3ZKR A;  5CFB A;  2X00 D;  3JAD A;  3U8N A;  2WN9 A;  3WTJ A;  2QC1 B;  4AFH A;  4AFG A;  2Y7Y A;  3P50 A;  4ZR6 A;  3PMZ A;  2PGZ A;  2YOE A;  3TLW A;  4TNW A;  4HFD A;  4LML A;  2XQ7 A;  3RQW A;  3P4W A;  4ZZC A;  2WZY A;  5LG3 A;  2W8F A;  5L47 A;  3SH1 A;  3UU5 A;  3SQ6 A;  3WTI A;  3UUB A;  4QAB A;  4LMJ A;  4UXU A;  4F8H A;  4QH5 A;  5HEJ A;  4TWH A;  5J5F A;  5J5H A;  3EAM A;  3WTN A;  4NZB A;  2BYS A;  2Y58 A;  2Y54 A;  4UM3 A;  2ZJV A;  4A98 A;  2XZ6 A;  3TLU A; 
#chains in the Genus database with same CATH topology
 3TLV A;  3WTM A;  3RI5 A;  2YME A;  3C79 A;  4IL9 A;  4Z91 A;  4IRE A;  3UU4 A;  5TVC A;  3C84 A;  4HFC A;  4EZ1 A;  3RIA A;  5LXB A;  2Y57 A;  5AFK A;  2YN6 A;  5AFJ A;  3RHW A;  2BR7 A;  2XQ6 A;  3ZDH A;  2XQ4 A;  4UY2 A;  4TWD A;  4QH1 A;  3UU8 A;  4ZZB A;  5J5I A;  3JAF A;  4QAA A;  5HEO A;  4ILB A;  1UX2 A;  2X00 A;  4QAC A;  2XZ5 A;  3U8L A;  4B5D A;  2XNV A;  3RIF A;  2WNJ A;  3RQU A;  3PEO A;  2YMD A;  5IUX A;  4FRR A;  4BFQ A;  3LSV A;  3UU3 A;  2BR8 A;  4ILC A;  4ZK4 A;  2WNL A;  4X5T A;  5HEG A;  5L4E A;  4ZJS A;  3EHZ A;  5FJV A;  4TNV A;  4IL4 A;  2BJ0 A;  5CO5 A;  2WNC A;  2XYS A;  1UV6 A;  4QH4 A;  4LMK A;  4UM1 A;  2ZJU A;  5L4H A;  5J5G A;  5SYO A;  4D01 A;  2VL0 A;  2XQ3 A;  5AFM A;  3WTK A;  2BG9 A;  5AFH A;  1I9B A;  3SQ9 A;  3WTO A;  4BQT A;  4NPP A;  4TWF A;  2UZ6 A;  2BYQ A;  5AFL A;  3TLT A;  2BG9 C;  3U8M A;  4ILA A;  4COF A;  2XQ8 A;  2XQA A;  3UQ4 A;  2XNU A;  3ZDG A;  4A97 A;  5KE4 A;  2BYN A;  2YKS A;  3U8K A;  5KZU A;  3GUA A;  2C9T A;  2BG9 B;  4HQP A;  4ALX A;  2XNT A;  4HFB A;  3WTL A;  5HEH A;  4DBM A;  5BW2 A;  5AFN A;  5J0Z A;  1UW6 A;  4WV9 A;  2BYR A;  5HCM A;  5HCJ A;  4ZRU A;  2Y56 A;  2XQ9 A;  3UQ7 A;  4XK9 A;  5JME A;  3U8J A;  5BRX A;  4HFH A;  2W8G A;  4ZJT A;  2PH9 A;  3WIP A;  2BG9 E;  2XYT A;  4UM3 S;  2BYP A;  4HFE A;  4PIR A;  2XQ5 A;  3SIO A;  3UU6 A;  5HEU A;  4ZK1 A;  4UM3 P;  5BP0 A;  4HFI A;  4AFT A;  3TLS A;  4XHE A;  5AIN A;  3JAE A;  3WTH A;  4Z90 A;  5AFM B;  3IGQ A;  3T4M A;  3EI0 A;  3ZKR A;  5CFB A;  2X00 D;  3JAD A;  3U8N A;  2WN9 A;  3WTJ A;  2QC1 B;  4AFH A;  4AFG A;  2Y7Y A;  3P50 A;  4ZR6 A;  3PMZ A;  2PGZ A;  2YOE A;  3TLW A;  4TNW A;  4HFD A;  4LML A;  2XQ7 A;  3RQW A;  3P4W A;  4ZZC A;  2WZY A;  5LG3 A;  2W8F A;  5L47 A;  3SH1 A;  3UU5 A;  3SQ6 A;  3WTI A;  3UUB A;  4QAB A;  4LMJ A;  4UXU A;  4F8H A;  4QH5 A;  5HEJ A;  4TWH A;  5J5F A;  5J5H A;  3EAM A;  3WTN A;  4NZB A;  2BYS A;  2Y58 A;  2Y54 A;  4UM3 A;  2ZJV A;  4A98 A;  2XZ6 A;  3TLU A; 
#chains in the Genus database with same CATH homology
 3TLV A;  3WTM A;  3RI5 A;  2YME A;  3C79 A;  4IL9 A;  4Z91 A;  4IRE A;  3UU4 A;  5TVC A;  3C84 A;  4HFC A;  4EZ1 A;  3RIA A;  5LXB A;  2Y57 A;  5AFK A;  2YN6 A;  5AFJ A;  3RHW A;  2BR7 A;  2XQ6 A;  3ZDH A;  2XQ4 A;  4UY2 A;  4TWD A;  4QH1 A;  3UU8 A;  4ZZB A;  5J5I A;  3JAF A;  4QAA A;  5HEO A;  4ILB A;  1UX2 A;  2X00 A;  4QAC A;  2XZ5 A;  3U8L A;  4B5D A;  2XNV A;  3RIF A;  2WNJ A;  3RQU A;  3PEO A;  2YMD A;  5IUX A;  4FRR A;  4BFQ A;  3LSV A;  3UU3 A;  2BR8 A;  4ILC A;  4ZK4 A;  2WNL A;  4X5T A;  5HEG A;  5L4E A;  4ZJS A;  3EHZ A;  5FJV A;  4TNV A;  4IL4 A;  2BJ0 A;  5CO5 A;  2WNC A;  2XYS A;  1UV6 A;  4QH4 A;  4LMK A;  4UM1 A;  2ZJU A;  5L4H A;  5J5G A;  5SYO A;  4D01 A;  2VL0 A;  2XQ3 A;  5AFM A;  3WTK A;  2BG9 A;  5AFH A;  1I9B A;  3SQ9 A;  3WTO A;  4BQT A;  4NPP A;  4TWF A;  2UZ6 A;  2BYQ A;  5AFL A;  3TLT A;  2BG9 C;  3U8M A;  4ILA A;  4COF A;  2XQ8 A;  2XQA A;  3UQ4 A;  2XNU A;  3ZDG A;  4A97 A;  5KE4 A;  2BYN A;  2YKS A;  3U8K A;  5KZU A;  3GUA A;  2C9T A;  2BG9 B;  4HQP A;  4ALX A;  2XNT A;  4HFB A;  3WTL A;  5HEH A;  4DBM A;  5BW2 A;  5AFN A;  5J0Z A;  1UW6 A;  4WV9 A;  2BYR A;  5HCM A;  5HCJ A;  4ZRU A;  2Y56 A;  2XQ9 A;  3UQ7 A;  4XK9 A;  5JME A;  3U8J A;  5BRX A;  4HFH A;  2W8G A;  4ZJT A;  2PH9 A;  3WIP A;  2BG9 E;  2XYT A;  4UM3 S;  2BYP A;  4HFE A;  4PIR A;  2XQ5 A;  3SIO A;  3UU6 A;  5HEU A;  4ZK1 A;  4UM3 P;  5BP0 A;  4HFI A;  4AFT A;  3TLS A;  4XHE A;  5AIN A;  3JAE A;  3WTH A;  4Z90 A;  5AFM B;  3IGQ A;  3T4M A;  3EI0 A;  3ZKR A;  5CFB A;  2X00 D;  3JAD A;  3U8N A;  2WN9 A;  3WTJ A;  2QC1 B;  4AFH A;  4AFG A;  2Y7Y A;  3P50 A;  4ZR6 A;  3PMZ A;  2PGZ A;  2YOE A;  3TLW A;  4TNW A;  4HFD A;  4LML A;  2XQ7 A;  3RQW A;  3P4W A;  4ZZC A;  2WZY A;  5LG3 A;  2W8F A;  5L47 A;  3SH1 A;  3UU5 A;  3SQ6 A;  3WTI A;  3UUB A;  4QAB A;  4LMJ A;  4UXU A;  4F8H A;  4QH5 A;  5HEJ A;  4TWH A;  5J5F A;  5J5H A;  3EAM A;  3WTN A;  4NZB A;  2BYS A;  2Y58 A;  2Y54 A;  4UM3 A;  2ZJV A;  4A98 A;  2XZ6 A;  3TLU A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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