5FJVA

Crystal structure of the extracellular domain of alpha2 nicotinic acetylcholine receptor in pentameric assembly
Total Genus 35
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
35
sequence length
206
structure length
206
Chain Sequence
DRLFKHLFRGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWSDYKLRWNPTDFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVPPAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDLKDYWESGEWAIVNATGTYNSKKYDCCAEIYPDVTYAFVIRRLP
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structure of a Human Neuronal Nachr Extracellular Domain in Pentameric Assembly: Ligand-Bound Alpah2 Homopentamer.
pubmed doi rcsb
molecule tags Acetylcholine-binding protein
source organism Homo sapiens
molecule keywords NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-2
total genus 35
structure length 206
sequence length 206
chains with identical sequence B, C, D, E
ec nomenclature
pdb deposition date 2015-10-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02931 Neur_chan_LBD Neurotransmitter-gated ion-channel ligand binding domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.170.10 Mainly Beta Distorted Sandwich Acetylcholine Binding Protein; Chain: A, Neurotransmitter-gated ion-channel ligand-binding domain 5fjvA00
1UW6A 4HFEA 4LMLA 4AFTA 4ZK1A 4AFHA 4XK9A 5CFBA 4QABA 4BFQA 2BYNA 2VL0A 3U8KA 4HFIA 4F8HA 3UU8A 3PEOA 3WTOA 5AFLA 5JMEA 4UM3A 3P50A 5L4EA 5HCMA 2YN6A 5FJVA 4IL9A 5J5HA 3TLWA 2YMDA 2BG9B 3U8JA 3UU6A 3UQ7A 2XQ9A 4UXUA 5J5GA 3TLTA 2BYPA 4HFDA 2YOEA 4QH1A 2XNTA 4EZ1A 4COFA 3T4MA 5AFMA 5LXBA 2X00A 4WV9A 4ILAA 5KZUA 4DBMA 2BYQA 4X5TA 5HEGA 5BP0A 3SQ9A 4ZJTA 2XZ6A 4Z90A 3RQUA 2XNVA 4XHEA 5L4HA 4Z91A 2Y7YA 5HEHA 5KE4A 4LMKA 2BR7A 2BG9C 3RI5A 2WZYA 4TNVA 3UUBA 2PGZA 3U8LA 4ZK4A 2YKSA 3JAFA 5J5IA 2BG9E 3RIAA 4AFGA 4ILBA 5AFJA 5HEJA 1I9BA 4ZZCA 4TWDA 3PMZA 3LSVA 2XYSA 3RHWA 5TVCA 4FRRA 4QACA 4ZZBA 3U8NA 2BR8A 3C79A 2Y57A 5BRXA 3WTHA 2WNJA 4UM1A 2W8GA 2XZ5A 2XNUA 4QAAA 2W8FA 2XQ4A 2Y56A 3WTIA 3U8MA 2XQ6A 3IGQA 4BQTA 4UY2A 4B5DA 2XQ7A 2ZJUA 2XQ5A 2YMEA 4NZBA 3UU5A 2XQ3A 3TLVA 2XQ8A 3WTNA 2XYTA 5AFMB 4LMJA 3SIOA 2UZ6A 5CO5A 4PIRA 3UU4A 3JAEA 4ZJSA 2BG9A 3C84A 3GUAA 5AFHA 4QH5A 3WTKA 2WNLA 3TLSA 2BYSA 3SQ6A 3ZKRA 3EAMA 3TLUA 4A97A 4D01A 5AFNA 2BYRA 5BW2A 5AFKA 3SH1A 5IUXA 5J5FA 4IL4A 4ILCA 2Y54A 3JADA 1UX2A 2XQAA 2BJ0A 4ZRUA 4ALXA 4TWFA 2QC1B 5HEOA 5AINA 3RIFA 3WTLA 3UQ4A 2WNCA 4UM3S 4NPPA 5SYOA 4TWHA 3UU3A 4ZR6A 4HFHA 3WIPA 3P4WA 4QH4A 2ZJVA 5LG3A 4HFBA 5HEUA 5HCJA 2C9TA 4UM3P 2X00D 4HFCA 4HQPA 3WTJA 3WTMA 3ZDHA 3EI0A 5L47A 2WN9A 2PH9A 4IREA 3RQWA 4A98A 1UV6A 2Y58A 5J0ZA 3EHZA 3ZDGA 4TNWA
chains in the Genus database with same CATH superfamily
1UW6A 4HFEA 4LMLA 4AFTA 4ZK1A 4AFHA 4XK9A 5CFBA 4QABA 4BFQA 2BYNA 2VL0A 3U8KA 4HFIA 4F8HA 3UU8A 3PEOA 3WTOA 5AFLA 5JMEA 4UM3A 3P50A 5L4EA 5HCMA 2YN6A 5FJVA 4IL9A 5J5HA 3TLWA 2YMDA 2BG9B 3U8JA 3UU6A 3UQ7A 2XQ9A 4UXUA 5J5GA 3TLTA 2BYPA 4HFDA 2YOEA 4QH1A 2XNTA 4EZ1A 4COFA 3T4MA 5AFMA 5LXBA 2X00A 4WV9A 4ILAA 5KZUA 4DBMA 2BYQA 4X5TA 5HEGA 5BP0A 3SQ9A 4ZJTA 2XZ6A 4Z90A 3RQUA 2XNVA 4XHEA 5L4HA 4Z91A 2Y7YA 5HEHA 5KE4A 4LMKA 2BR7A 2BG9C 3RI5A 2WZYA 4TNVA 3UUBA 2PGZA 3U8LA 4ZK4A 2YKSA 3JAFA 5J5IA 2BG9E 3RIAA 4AFGA 4ILBA 5AFJA 5HEJA 1I9BA 4ZZCA 4TWDA 3PMZA 3LSVA 2XYSA 3RHWA 5TVCA 4FRRA 4QACA 4ZZBA 3U8NA 2BR8A 3C79A 2Y57A 5BRXA 3WTHA 2WNJA 4UM1A 2W8GA 2XZ5A 2XNUA 4QAAA 2W8FA 2XQ4A 2Y56A 3WTIA 3U8MA 2XQ6A 3IGQA 4BQTA 4UY2A 4B5DA 2XQ7A 2ZJUA 2XQ5A 2YMEA 4NZBA 3UU5A 2XQ3A 3TLVA 2XQ8A 3WTNA 2XYTA 5AFMB 4LMJA 3SIOA 2UZ6A 5CO5A 4PIRA 3UU4A 3JAEA 4ZJSA 2BG9A 3C84A 3GUAA 5AFHA 4QH5A 3WTKA 2WNLA 3TLSA 2BYSA 3SQ6A 3ZKRA 3EAMA 3TLUA 4A97A 4D01A 5AFNA 2BYRA 5BW2A 5AFKA 3SH1A 5IUXA 5J5FA 4IL4A 4ILCA 2Y54A 3JADA 1UX2A 2XQAA 2BJ0A 4ZRUA 4ALXA 4TWFA 2QC1B 5HEOA 5AINA 3RIFA 3WTLA 3UQ4A 2WNCA 4UM3S 4NPPA 5SYOA 4TWHA 3UU3A 4ZR6A 4HFHA 3WIPA 3P4WA 4QH4A 2ZJVA 5LG3A 4HFBA 5HEUA 5HCJA 2C9TA 4UM3P 2X00D 4HFCA 4HQPA 3WTJA 3WTMA 3ZDHA 3EI0A 5L47A 2WN9A 2PH9A 4IREA 3RQWA 4A98A 1UV6A 2Y58A 5J0ZA 3EHZA 3ZDGA 4TNWA
chains in the Genus database with same CATH topology
1UW6A 4HFEA 4LMLA 4AFTA 4ZK1A 4AFHA 4XK9A 5CFBA 4QABA 4BFQA 2BYNA 2VL0A 3U8KA 4HFIA 4F8HA 3UU8A 3PEOA 3WTOA 5AFLA 5JMEA 4UM3A 3P50A 5L4EA 5HCMA 2YN6A 5FJVA 4IL9A 5J5HA 3TLWA 2YMDA 2BG9B 3U8JA 3UU6A 3UQ7A 2XQ9A 4UXUA 5J5GA 3TLTA 2BYPA 4HFDA 2YOEA 4QH1A 2XNTA 4EZ1A 4COFA 3T4MA 5AFMA 5LXBA 2X00A 4WV9A 4ILAA 5KZUA 4DBMA 2BYQA 4X5TA 5HEGA 5BP0A 3SQ9A 4ZJTA 2XZ6A 4Z90A 3RQUA 2XNVA 4XHEA 5L4HA 4Z91A 2Y7YA 5HEHA 5KE4A 4LMKA 2BR7A 2BG9C 3RI5A 2WZYA 4TNVA 3UUBA 2PGZA 3U8LA 4ZK4A 2YKSA 3JAFA 5J5IA 2BG9E 3RIAA 4AFGA 4ILBA 5AFJA 5HEJA 1I9BA 4ZZCA 4TWDA 3PMZA 3LSVA 2XYSA 3RHWA 5TVCA 4FRRA 4QACA 4ZZBA 3U8NA 2BR8A 3C79A 2Y57A 5BRXA 3WTHA 2WNJA 4UM1A 2W8GA 2XZ5A 2XNUA 4QAAA 2W8FA 2XQ4A 2Y56A 3WTIA 3U8MA 2XQ6A 3IGQA 4BQTA 4UY2A 4B5DA 2XQ7A 2ZJUA 2XQ5A 2YMEA 4NZBA 3UU5A 2XQ3A 3TLVA 2XQ8A 3WTNA 2XYTA 5AFMB 4LMJA 3SIOA 2UZ6A 5CO5A 4PIRA 3UU4A 3JAEA 4ZJSA 2BG9A 3C84A 3GUAA 5AFHA 4QH5A 3WTKA 2WNLA 3TLSA 2BYSA 3SQ6A 3ZKRA 3EAMA 3TLUA 4A97A 4D01A 5AFNA 2BYRA 5BW2A 5AFKA 3SH1A 5IUXA 5J5FA 4IL4A 4ILCA 2Y54A 3JADA 1UX2A 2XQAA 2BJ0A 4ZRUA 4ALXA 4TWFA 2QC1B 5HEOA 5AINA 3RIFA 3WTLA 3UQ4A 2WNCA 4UM3S 4NPPA 5SYOA 4TWHA 3UU3A 4ZR6A 4HFHA 3WIPA 3P4WA 4QH4A 2ZJVA 5LG3A 4HFBA 5HEUA 5HCJA 2C9TA 4UM3P 2X00D 4HFCA 4HQPA 3WTJA 3WTMA 3ZDHA 3EI0A 5L47A 2WN9A 2PH9A 4IREA 3RQWA 4A98A 1UV6A 2Y58A 5J0ZA 3EHZA 3ZDGA 4TNWA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1UW6 A;  4HFE A;  4LML A;  4AFT A;  4ZK1 A;  4AFH A;  4XK9 A;  5CFB A;  4QAB A;  4BFQ A;  2BYN A;  2VL0 A;  3U8K A;  4HFI A;  4F8H A;  3UU8 A;  3PEO A;  3WTO A;  5AFL A;  5JME A;  4UM3 A;  3P50 A;  5L4E A;  5HCM A;  2YN6 A;  5FJV A;  4IL9 A;  5J5H A;  3TLW A;  2YMD A;  2BG9 B;  3U8J A;  3UU6 A;  3UQ7 A;  2XQ9 A;  4UXU A;  5J5G A;  3TLT A;  2BYP A;  4HFD A;  2YOE A;  4QH1 A;  2XNT A;  4EZ1 A;  4COF A;  3T4M A;  5AFM A;  5LXB A;  2X00 A;  4WV9 A;  4ILA A;  5KZU A;  4DBM A;  2BYQ A;  4X5T A;  5HEG A;  5BP0 A;  3SQ9 A;  4ZJT A;  2XZ6 A;  4Z90 A;  3RQU A;  2XNV A;  4XHE A;  5L4H A;  4Z91 A;  2Y7Y A;  5HEH A;  5KE4 A;  4LMK A;  2BR7 A;  2BG9 C;  3RI5 A;  2WZY A;  4TNV A;  3UUB A;  2PGZ A;  3U8L A;  4ZK4 A;  2YKS A;  3JAF A;  5J5I A;  2BG9 E;  3RIA A;  4AFG A;  4ILB A;  5AFJ A;  5HEJ A;  1I9B A;  4ZZC A;  4TWD A;  3PMZ A;  3LSV A;  2XYS A;  3RHW A;  5TVC A;  4FRR A;  4QAC A;  4ZZB A;  3U8N A;  2BR8 A;  3C79 A;  2Y57 A;  5BRX A;  3WTH A;  2WNJ A;  4UM1 A;  2W8G A;  2XZ5 A;  2XNU A;  4QAA A;  2W8F A;  2XQ4 A;  2Y56 A;  3WTI A;  3U8M A;  2XQ6 A;  3IGQ A;  4BQT A;  4UY2 A;  4B5D A;  2XQ7 A;  2ZJU A;  2XQ5 A;  2YME A;  4NZB A;  3UU5 A;  2XQ3 A;  3TLV A;  2XQ8 A;  3WTN A;  2XYT A;  5AFM B;  4LMJ A;  3SIO A;  2UZ6 A;  5CO5 A;  4PIR A;  3UU4 A;  3JAE A;  4ZJS A;  2BG9 A;  3C84 A;  3GUA A;  5AFH A;  4QH5 A;  3WTK A;  2WNL A;  3TLS A;  2BYS A;  3SQ6 A;  3ZKR A;  3EAM A;  3TLU A;  4A97 A;  4D01 A;  5AFN A;  2BYR A;  5BW2 A;  5AFK A;  3SH1 A;  5IUX A;  5J5F A;  4IL4 A;  4ILC A;  2Y54 A;  3JAD A;  1UX2 A;  2XQA A;  2BJ0 A;  4ZRU A;  4ALX A;  4TWF A;  2QC1 B;  5HEO A;  5AIN A;  3RIF A;  3WTL A;  3UQ4 A;  2WNC A;  4UM3 S;  4NPP A;  5SYO A;  4TWH A;  3UU3 A;  4ZR6 A;  4HFH A;  3WIP A;  3P4W A;  4QH4 A;  2ZJV A;  5LG3 A;  4HFB A;  5HEU A;  5HCJ A;  2C9T A;  4UM3 P;  2X00 D;  4HFC A;  4HQP A;  3WTJ A;  3WTM A;  3ZDH A;  3EI0 A;  5L47 A;  2WN9 A;  2PH9 A;  4IRE A;  3RQW A;  4A98 A;  1UV6 A;  2Y58 A;  5J0Z A;  3EHZ A;  3ZDG A;  4TNW A; 
#chains in the Genus database with same CATH topology
 1UW6 A;  4HFE A;  4LML A;  4AFT A;  4ZK1 A;  4AFH A;  4XK9 A;  5CFB A;  4QAB A;  4BFQ A;  2BYN A;  2VL0 A;  3U8K A;  4HFI A;  4F8H A;  3UU8 A;  3PEO A;  3WTO A;  5AFL A;  5JME A;  4UM3 A;  3P50 A;  5L4E A;  5HCM A;  2YN6 A;  5FJV A;  4IL9 A;  5J5H A;  3TLW A;  2YMD A;  2BG9 B;  3U8J A;  3UU6 A;  3UQ7 A;  2XQ9 A;  4UXU A;  5J5G A;  3TLT A;  2BYP A;  4HFD A;  2YOE A;  4QH1 A;  2XNT A;  4EZ1 A;  4COF A;  3T4M A;  5AFM A;  5LXB A;  2X00 A;  4WV9 A;  4ILA A;  5KZU A;  4DBM A;  2BYQ A;  4X5T A;  5HEG A;  5BP0 A;  3SQ9 A;  4ZJT A;  2XZ6 A;  4Z90 A;  3RQU A;  2XNV A;  4XHE A;  5L4H A;  4Z91 A;  2Y7Y A;  5HEH A;  5KE4 A;  4LMK A;  2BR7 A;  2BG9 C;  3RI5 A;  2WZY A;  4TNV A;  3UUB A;  2PGZ A;  3U8L A;  4ZK4 A;  2YKS A;  3JAF A;  5J5I A;  2BG9 E;  3RIA A;  4AFG A;  4ILB A;  5AFJ A;  5HEJ A;  1I9B A;  4ZZC A;  4TWD A;  3PMZ A;  3LSV A;  2XYS A;  3RHW A;  5TVC A;  4FRR A;  4QAC A;  4ZZB A;  3U8N A;  2BR8 A;  3C79 A;  2Y57 A;  5BRX A;  3WTH A;  2WNJ A;  4UM1 A;  2W8G A;  2XZ5 A;  2XNU A;  4QAA A;  2W8F A;  2XQ4 A;  2Y56 A;  3WTI A;  3U8M A;  2XQ6 A;  3IGQ A;  4BQT A;  4UY2 A;  4B5D A;  2XQ7 A;  2ZJU A;  2XQ5 A;  2YME A;  4NZB A;  3UU5 A;  2XQ3 A;  3TLV A;  2XQ8 A;  3WTN A;  2XYT A;  5AFM B;  4LMJ A;  3SIO A;  2UZ6 A;  5CO5 A;  4PIR A;  3UU4 A;  3JAE A;  4ZJS A;  2BG9 A;  3C84 A;  3GUA A;  5AFH A;  4QH5 A;  3WTK A;  2WNL A;  3TLS A;  2BYS A;  3SQ6 A;  3ZKR A;  3EAM A;  3TLU A;  4A97 A;  4D01 A;  5AFN A;  2BYR A;  5BW2 A;  5AFK A;  3SH1 A;  5IUX A;  5J5F A;  4IL4 A;  4ILC A;  2Y54 A;  3JAD A;  1UX2 A;  2XQA A;  2BJ0 A;  4ZRU A;  4ALX A;  4TWF A;  2QC1 B;  5HEO A;  5AIN A;  3RIF A;  3WTL A;  3UQ4 A;  2WNC A;  4UM3 S;  4NPP A;  5SYO A;  4TWH A;  3UU3 A;  4ZR6 A;  4HFH A;  3WIP A;  3P4W A;  4QH4 A;  2ZJV A;  5LG3 A;  4HFB A;  5HEU A;  5HCJ A;  2C9T A;  4UM3 P;  2X00 D;  4HFC A;  4HQP A;  3WTJ A;  3WTM A;  3ZDH A;  3EI0 A;  5L47 A;  2WN9 A;  2PH9 A;  4IRE A;  3RQW A;  4A98 A;  1UV6 A;  2Y58 A;  5J0Z A;  3EHZ A;  3ZDG A;  4TNW A; 
#chains in the Genus database with same CATH homology
 1UW6 A;  4HFE A;  4LML A;  4AFT A;  4ZK1 A;  4AFH A;  4XK9 A;  5CFB A;  4QAB A;  4BFQ A;  2BYN A;  2VL0 A;  3U8K A;  4HFI A;  4F8H A;  3UU8 A;  3PEO A;  3WTO A;  5AFL A;  5JME A;  4UM3 A;  3P50 A;  5L4E A;  5HCM A;  2YN6 A;  5FJV A;  4IL9 A;  5J5H A;  3TLW A;  2YMD A;  2BG9 B;  3U8J A;  3UU6 A;  3UQ7 A;  2XQ9 A;  4UXU A;  5J5G A;  3TLT A;  2BYP A;  4HFD A;  2YOE A;  4QH1 A;  2XNT A;  4EZ1 A;  4COF A;  3T4M A;  5AFM A;  5LXB A;  2X00 A;  4WV9 A;  4ILA A;  5KZU A;  4DBM A;  2BYQ A;  4X5T A;  5HEG A;  5BP0 A;  3SQ9 A;  4ZJT A;  2XZ6 A;  4Z90 A;  3RQU A;  2XNV A;  4XHE A;  5L4H A;  4Z91 A;  2Y7Y A;  5HEH A;  5KE4 A;  4LMK A;  2BR7 A;  2BG9 C;  3RI5 A;  2WZY A;  4TNV A;  3UUB A;  2PGZ A;  3U8L A;  4ZK4 A;  2YKS A;  3JAF A;  5J5I A;  2BG9 E;  3RIA A;  4AFG A;  4ILB A;  5AFJ A;  5HEJ A;  1I9B A;  4ZZC A;  4TWD A;  3PMZ A;  3LSV A;  2XYS A;  3RHW A;  5TVC A;  4FRR A;  4QAC A;  4ZZB A;  3U8N A;  2BR8 A;  3C79 A;  2Y57 A;  5BRX A;  3WTH A;  2WNJ A;  4UM1 A;  2W8G A;  2XZ5 A;  2XNU A;  4QAA A;  2W8F A;  2XQ4 A;  2Y56 A;  3WTI A;  3U8M A;  2XQ6 A;  3IGQ A;  4BQT A;  4UY2 A;  4B5D A;  2XQ7 A;  2ZJU A;  2XQ5 A;  2YME A;  4NZB A;  3UU5 A;  2XQ3 A;  3TLV A;  2XQ8 A;  3WTN A;  2XYT A;  5AFM B;  4LMJ A;  3SIO A;  2UZ6 A;  5CO5 A;  4PIR A;  3UU4 A;  3JAE A;  4ZJS A;  2BG9 A;  3C84 A;  3GUA A;  5AFH A;  4QH5 A;  3WTK A;  2WNL A;  3TLS A;  2BYS A;  3SQ6 A;  3ZKR A;  3EAM A;  3TLU A;  4A97 A;  4D01 A;  5AFN A;  2BYR A;  5BW2 A;  5AFK A;  3SH1 A;  5IUX A;  5J5F A;  4IL4 A;  4ILC A;  2Y54 A;  3JAD A;  1UX2 A;  2XQA A;  2BJ0 A;  4ZRU A;  4ALX A;  4TWF A;  2QC1 B;  5HEO A;  5AIN A;  3RIF A;  3WTL A;  3UQ4 A;  2WNC A;  4UM3 S;  4NPP A;  5SYO A;  4TWH A;  3UU3 A;  4ZR6 A;  4HFH A;  3WIP A;  3P4W A;  4QH4 A;  2ZJV A;  5LG3 A;  4HFB A;  5HEU A;  5HCJ A;  2C9T A;  4UM3 P;  2X00 D;  4HFC A;  4HQP A;  3WTJ A;  3WTM A;  3ZDH A;  3EI0 A;  5L47 A;  2WN9 A;  2PH9 A;  4IRE A;  3RQW A;  4A98 A;  1UV6 A;  2Y58 A;  5J0Z A;  3EHZ A;  3ZDG A;  4TNW A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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