5J5FA

X-ray crystal structure of acetylcholine binding protein (achbp) in complex with n4,n4-bis[(pyridin-2-yl)methyl]-6-(thiophen-3-yl)pyrimidine-2,4-diamine
Total Genus 57
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
57
sequence length
212
structure length
212
Chain Sequence
DYKDDDDKLDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLARVVSDGEVLYMPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTTENSDDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Substituted 2-Aminopyrimidines Selective for alpha 7-Nicotinic Acetylcholine Receptor Activation and Association with Acetylcholine Binding Proteins.
pubmed doi rcsb
molecule tags Acetylcholine-binding protein
source organism Lymnaea stagnalis
molecule keywords Acetylcholine-binding protein
total genus 57
structure length 212
sequence length 212
chains with identical sequence B, C, D, E, F, G, H, I, J
ec nomenclature
pdb deposition date 2016-04-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02931 Neur_chan_LBD Neurotransmitter-gated ion-channel ligand binding domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.170.10 Mainly Beta Distorted Sandwich Acetylcholine Binding Protein; Chain: A, Neurotransmitter-gated ion-channel ligand-binding domain 5j5fA00
5L4HA 2WNLA 5BRXA 2WNJA 4TNWA 4XK9A 4UM3A 5HEHA 4A97A 4IL4A 3WTHA 3TLUA 3UQ4A 3UU4A 4Z91A 4ILCA 5BP0A 2W8GA 2WN9A 2YMEA 4IL9A 3RIFA 2BYQA 2W8FA 3RQWA 3JADA 3RQUA 4F8HA 4UM3P 1UX2A 5HEJA 4BQTA 5KE4A 5AFNA 3UU6A 2XNTA 2BYSA 4QH1A 4XHEA 4COFA 4LMLA 3C79A 2BYPA 3EI0A 4ZR6A 5TVCA 3P4WA 2Y56A 4AFTA 5BW2A 3JAEA 5JMEA 3WTJA 2Y57A 4ZJTA 2Y54A 4HFIA 3PEOA 3UQ7A 5HEUA 5AFHA 5AFMA 4UM3S 2BG9C 2X00D 5AFMB 3SQ9A 2XZ5A 3UU5A 2XQ3A 4QH5A 4DBMA 4AFGA 1UW6A 4ZZCA 5HEGA 5J0ZA 4UXUA 3ZDGA 5J5IA 5LXBA 3IGQA 4HFHA 5HCJA 3U8LA 3WTLA 3TLTA 4B5DA 5CO5A 3WTIA 3ZKRA 3ZDHA 3PMZA 5HCMA 2XYTA 2C9TA 4WV9A 3RI5A 2PGZA 4HQPA 4A98A 2XNUA 4NPPA 2YN6A 2BR8A 3EAMA 3WIPA 4ZK1A 4ZZBA 1I9BA 2XYSA 4PIRA 4UY2A 2UZ6A 2PH9A 3SH1A 4TNVA 4TWFA 2YOEA 2ZJVA 1UV6A 2XNVA 4LMKA 3RHWA 3WTMA 2BG9A 2XQ4A 2VL0A 2XQ7A 3T4MA 5IUXA 3TLSA 5J5HA 2Y58A 2BG9B 2XQ9A 3JAFA 5LG3A 4IREA 3LSVA 2XQAA 4Z90A 5AFJA 4ZJSA 4FRRA 2X00A 5AFKA 3RIAA 5AINA 2BYNA 3C84A 2WZYA 4TWDA 5HEOA 3EHZA 4ZK4A 4TWHA 2BJ0A 2QC1B 2XQ6A 3WTKA 4HFCA 4ZRUA 4QACA 3GUAA 2XZ6A 3UU8A 3WTNA 4ALXA 4QAAA 3U8JA 5L47A 5KZUA 3UU3A 4X5TA 4D01A 5L4EA 2WNCA 4BFQA 4QH4A 2XQ5A 4UM1A 5SYOA 2BR7A 2Y7YA 3P50A 3U8NA 4HFBA 4QABA 4NZBA 5CFBA 2BYRA 3U8KA 5J5FA 3WTOA 3TLVA 4ILBA 4HFDA 2ZJUA 2BG9E 4LMJA 2YKSA 4AFHA 3U8MA 2YMDA 4EZ1A 4HFEA 2XQ8A 4ILAA 3TLWA 3SQ6A 5AFLA 5FJVA 3SIOA 5J5GA 3UUBA
chains in the Genus database with same CATH superfamily
5L4HA 2WNLA 5BRXA 2WNJA 4TNWA 4XK9A 4UM3A 5HEHA 4A97A 4IL4A 3WTHA 3TLUA 3UQ4A 3UU4A 4Z91A 4ILCA 5BP0A 2W8GA 2WN9A 2YMEA 4IL9A 3RIFA 2BYQA 2W8FA 3RQWA 3JADA 3RQUA 4F8HA 4UM3P 1UX2A 5HEJA 4BQTA 5KE4A 5AFNA 3UU6A 2XNTA 2BYSA 4QH1A 4XHEA 4COFA 4LMLA 3C79A 2BYPA 3EI0A 4ZR6A 5TVCA 3P4WA 2Y56A 4AFTA 5BW2A 3JAEA 5JMEA 3WTJA 2Y57A 4ZJTA 2Y54A 4HFIA 3PEOA 3UQ7A 5HEUA 5AFHA 5AFMA 4UM3S 2BG9C 2X00D 5AFMB 3SQ9A 2XZ5A 3UU5A 2XQ3A 4QH5A 4DBMA 4AFGA 1UW6A 4ZZCA 5HEGA 5J0ZA 4UXUA 3ZDGA 5J5IA 5LXBA 3IGQA 4HFHA 5HCJA 3U8LA 3WTLA 3TLTA 4B5DA 5CO5A 3WTIA 3ZKRA 3ZDHA 3PMZA 5HCMA 2XYTA 2C9TA 4WV9A 3RI5A 2PGZA 4HQPA 4A98A 2XNUA 4NPPA 2YN6A 2BR8A 3EAMA 3WIPA 4ZK1A 4ZZBA 1I9BA 2XYSA 4PIRA 4UY2A 2UZ6A 2PH9A 3SH1A 4TNVA 4TWFA 2YOEA 2ZJVA 1UV6A 2XNVA 4LMKA 3RHWA 3WTMA 2BG9A 2XQ4A 2VL0A 2XQ7A 3T4MA 5IUXA 3TLSA 5J5HA 2Y58A 2BG9B 2XQ9A 3JAFA 5LG3A 4IREA 3LSVA 2XQAA 4Z90A 5AFJA 4ZJSA 4FRRA 2X00A 5AFKA 3RIAA 5AINA 2BYNA 3C84A 2WZYA 4TWDA 5HEOA 3EHZA 4ZK4A 4TWHA 2BJ0A 2QC1B 2XQ6A 3WTKA 4HFCA 4ZRUA 4QACA 3GUAA 2XZ6A 3UU8A 3WTNA 4ALXA 4QAAA 3U8JA 5L47A 5KZUA 3UU3A 4X5TA 4D01A 5L4EA 2WNCA 4BFQA 4QH4A 2XQ5A 4UM1A 5SYOA 2BR7A 2Y7YA 3P50A 3U8NA 4HFBA 4QABA 4NZBA 5CFBA 2BYRA 3U8KA 5J5FA 3WTOA 3TLVA 4ILBA 4HFDA 2ZJUA 2BG9E 4LMJA 2YKSA 4AFHA 3U8MA 2YMDA 4EZ1A 4HFEA 2XQ8A 4ILAA 3TLWA 3SQ6A 5AFLA 5FJVA 3SIOA 5J5GA 3UUBA
chains in the Genus database with same CATH topology
5L4HA 2WNLA 5BRXA 2WNJA 4TNWA 4XK9A 4UM3A 5HEHA 4A97A 4IL4A 3WTHA 3TLUA 3UQ4A 3UU4A 4Z91A 4ILCA 5BP0A 2W8GA 2WN9A 2YMEA 4IL9A 3RIFA 2BYQA 2W8FA 3RQWA 3JADA 3RQUA 4F8HA 4UM3P 1UX2A 5HEJA 4BQTA 5KE4A 5AFNA 3UU6A 2XNTA 2BYSA 4QH1A 4XHEA 4COFA 4LMLA 3C79A 2BYPA 3EI0A 4ZR6A 5TVCA 3P4WA 2Y56A 4AFTA 5BW2A 3JAEA 5JMEA 3WTJA 2Y57A 4ZJTA 2Y54A 4HFIA 3PEOA 3UQ7A 5HEUA 5AFHA 5AFMA 4UM3S 2BG9C 2X00D 5AFMB 3SQ9A 2XZ5A 3UU5A 2XQ3A 4QH5A 4DBMA 4AFGA 1UW6A 4ZZCA 5HEGA 5J0ZA 4UXUA 3ZDGA 5J5IA 5LXBA 3IGQA 4HFHA 5HCJA 3U8LA 3WTLA 3TLTA 4B5DA 5CO5A 3WTIA 3ZKRA 3ZDHA 3PMZA 5HCMA 2XYTA 2C9TA 4WV9A 3RI5A 2PGZA 4HQPA 4A98A 2XNUA 4NPPA 2YN6A 2BR8A 3EAMA 3WIPA 4ZK1A 4ZZBA 1I9BA 2XYSA 4PIRA 4UY2A 2UZ6A 2PH9A 3SH1A 4TNVA 4TWFA 2YOEA 2ZJVA 1UV6A 2XNVA 4LMKA 3RHWA 3WTMA 2BG9A 2XQ4A 2VL0A 2XQ7A 3T4MA 5IUXA 3TLSA 5J5HA 2Y58A 2BG9B 2XQ9A 3JAFA 5LG3A 4IREA 3LSVA 2XQAA 4Z90A 5AFJA 4ZJSA 4FRRA 2X00A 5AFKA 3RIAA 5AINA 2BYNA 3C84A 2WZYA 4TWDA 5HEOA 3EHZA 4ZK4A 4TWHA 2BJ0A 2QC1B 2XQ6A 3WTKA 4HFCA 4ZRUA 4QACA 3GUAA 2XZ6A 3UU8A 3WTNA 4ALXA 4QAAA 3U8JA 5L47A 5KZUA 3UU3A 4X5TA 4D01A 5L4EA 2WNCA 4BFQA 4QH4A 2XQ5A 4UM1A 5SYOA 2BR7A 2Y7YA 3P50A 3U8NA 4HFBA 4QABA 4NZBA 5CFBA 2BYRA 3U8KA 5J5FA 3WTOA 3TLVA 4ILBA 4HFDA 2ZJUA 2BG9E 4LMJA 2YKSA 4AFHA 3U8MA 2YMDA 4EZ1A 4HFEA 2XQ8A 4ILAA 3TLWA 3SQ6A 5AFLA 5FJVA 3SIOA 5J5GA 3UUBA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5L4H A;  2WNL A;  5BRX A;  2WNJ A;  4TNW A;  4XK9 A;  4UM3 A;  5HEH A;  4A97 A;  4IL4 A;  3WTH A;  3TLU A;  3UQ4 A;  3UU4 A;  4Z91 A;  4ILC A;  5BP0 A;  2W8G A;  2WN9 A;  2YME A;  4IL9 A;  3RIF A;  2BYQ A;  2W8F A;  3RQW A;  3JAD A;  3RQU A;  4F8H A;  4UM3 P;  1UX2 A;  5HEJ A;  4BQT A;  5KE4 A;  5AFN A;  3UU6 A;  2XNT A;  2BYS A;  4QH1 A;  4XHE A;  4COF A;  4LML A;  3C79 A;  2BYP A;  3EI0 A;  4ZR6 A;  5TVC A;  3P4W A;  2Y56 A;  4AFT A;  5BW2 A;  3JAE A;  5JME A;  3WTJ A;  2Y57 A;  4ZJT A;  2Y54 A;  4HFI A;  3PEO A;  3UQ7 A;  5HEU A;  5AFH A;  5AFM A;  4UM3 S;  2BG9 C;  2X00 D;  5AFM B;  3SQ9 A;  2XZ5 A;  3UU5 A;  2XQ3 A;  4QH5 A;  4DBM A;  4AFG A;  1UW6 A;  4ZZC A;  5HEG A;  5J0Z A;  4UXU A;  3ZDG A;  5J5I A;  5LXB A;  3IGQ A;  4HFH A;  5HCJ A;  3U8L A;  3WTL A;  3TLT A;  4B5D A;  5CO5 A;  3WTI A;  3ZKR A;  3ZDH A;  3PMZ A;  5HCM A;  2XYT A;  2C9T A;  4WV9 A;  3RI5 A;  2PGZ A;  4HQP A;  4A98 A;  2XNU A;  4NPP A;  2YN6 A;  2BR8 A;  3EAM A;  3WIP A;  4ZK1 A;  4ZZB A;  1I9B A;  2XYS A;  4PIR A;  4UY2 A;  2UZ6 A;  2PH9 A;  3SH1 A;  4TNV A;  4TWF A;  2YOE A;  2ZJV A;  1UV6 A;  2XNV A;  4LMK A;  3RHW A;  3WTM A;  2BG9 A;  2XQ4 A;  2VL0 A;  2XQ7 A;  3T4M A;  5IUX A;  3TLS A;  5J5H A;  2Y58 A;  2BG9 B;  2XQ9 A;  3JAF A;  5LG3 A;  4IRE A;  3LSV A;  2XQA A;  4Z90 A;  5AFJ A;  4ZJS A;  4FRR A;  2X00 A;  5AFK A;  3RIA A;  5AIN A;  2BYN A;  3C84 A;  2WZY A;  4TWD A;  5HEO A;  3EHZ A;  4ZK4 A;  4TWH A;  2BJ0 A;  2QC1 B;  2XQ6 A;  3WTK A;  4HFC A;  4ZRU A;  4QAC A;  3GUA A;  2XZ6 A;  3UU8 A;  3WTN A;  4ALX A;  4QAA A;  3U8J A;  5L47 A;  5KZU A;  3UU3 A;  4X5T A;  4D01 A;  5L4E A;  2WNC A;  4BFQ A;  4QH4 A;  2XQ5 A;  4UM1 A;  5SYO A;  2BR7 A;  2Y7Y A;  3P50 A;  3U8N A;  4HFB A;  4QAB A;  4NZB A;  5CFB A;  2BYR A;  3U8K A;  5J5F A;  3WTO A;  3TLV A;  4ILB A;  4HFD A;  2ZJU A;  2BG9 E;  4LMJ A;  2YKS A;  4AFH A;  3U8M A;  2YMD A;  4EZ1 A;  4HFE A;  2XQ8 A;  4ILA A;  3TLW A;  3SQ6 A;  5AFL A;  5FJV A;  3SIO A;  5J5G A;  3UUB A; 
#chains in the Genus database with same CATH topology
 5L4H A;  2WNL A;  5BRX A;  2WNJ A;  4TNW A;  4XK9 A;  4UM3 A;  5HEH A;  4A97 A;  4IL4 A;  3WTH A;  3TLU A;  3UQ4 A;  3UU4 A;  4Z91 A;  4ILC A;  5BP0 A;  2W8G A;  2WN9 A;  2YME A;  4IL9 A;  3RIF A;  2BYQ A;  2W8F A;  3RQW A;  3JAD A;  3RQU A;  4F8H A;  4UM3 P;  1UX2 A;  5HEJ A;  4BQT A;  5KE4 A;  5AFN A;  3UU6 A;  2XNT A;  2BYS A;  4QH1 A;  4XHE A;  4COF A;  4LML A;  3C79 A;  2BYP A;  3EI0 A;  4ZR6 A;  5TVC A;  3P4W A;  2Y56 A;  4AFT A;  5BW2 A;  3JAE A;  5JME A;  3WTJ A;  2Y57 A;  4ZJT A;  2Y54 A;  4HFI A;  3PEO A;  3UQ7 A;  5HEU A;  5AFH A;  5AFM A;  4UM3 S;  2BG9 C;  2X00 D;  5AFM B;  3SQ9 A;  2XZ5 A;  3UU5 A;  2XQ3 A;  4QH5 A;  4DBM A;  4AFG A;  1UW6 A;  4ZZC A;  5HEG A;  5J0Z A;  4UXU A;  3ZDG A;  5J5I A;  5LXB A;  3IGQ A;  4HFH A;  5HCJ A;  3U8L A;  3WTL A;  3TLT A;  4B5D A;  5CO5 A;  3WTI A;  3ZKR A;  3ZDH A;  3PMZ A;  5HCM A;  2XYT A;  2C9T A;  4WV9 A;  3RI5 A;  2PGZ A;  4HQP A;  4A98 A;  2XNU A;  4NPP A;  2YN6 A;  2BR8 A;  3EAM A;  3WIP A;  4ZK1 A;  4ZZB A;  1I9B A;  2XYS A;  4PIR A;  4UY2 A;  2UZ6 A;  2PH9 A;  3SH1 A;  4TNV A;  4TWF A;  2YOE A;  2ZJV A;  1UV6 A;  2XNV A;  4LMK A;  3RHW A;  3WTM A;  2BG9 A;  2XQ4 A;  2VL0 A;  2XQ7 A;  3T4M A;  5IUX A;  3TLS A;  5J5H A;  2Y58 A;  2BG9 B;  2XQ9 A;  3JAF A;  5LG3 A;  4IRE A;  3LSV A;  2XQA A;  4Z90 A;  5AFJ A;  4ZJS A;  4FRR A;  2X00 A;  5AFK A;  3RIA A;  5AIN A;  2BYN A;  3C84 A;  2WZY A;  4TWD A;  5HEO A;  3EHZ A;  4ZK4 A;  4TWH A;  2BJ0 A;  2QC1 B;  2XQ6 A;  3WTK A;  4HFC A;  4ZRU A;  4QAC A;  3GUA A;  2XZ6 A;  3UU8 A;  3WTN A;  4ALX A;  4QAA A;  3U8J A;  5L47 A;  5KZU A;  3UU3 A;  4X5T A;  4D01 A;  5L4E A;  2WNC A;  4BFQ A;  4QH4 A;  2XQ5 A;  4UM1 A;  5SYO A;  2BR7 A;  2Y7Y A;  3P50 A;  3U8N A;  4HFB A;  4QAB A;  4NZB A;  5CFB A;  2BYR A;  3U8K A;  5J5F A;  3WTO A;  3TLV A;  4ILB A;  4HFD A;  2ZJU A;  2BG9 E;  4LMJ A;  2YKS A;  4AFH A;  3U8M A;  2YMD A;  4EZ1 A;  4HFE A;  2XQ8 A;  4ILA A;  3TLW A;  3SQ6 A;  5AFL A;  5FJV A;  3SIO A;  5J5G A;  3UUB A; 
#chains in the Genus database with same CATH homology
 5L4H A;  2WNL A;  5BRX A;  2WNJ A;  4TNW A;  4XK9 A;  4UM3 A;  5HEH A;  4A97 A;  4IL4 A;  3WTH A;  3TLU A;  3UQ4 A;  3UU4 A;  4Z91 A;  4ILC A;  5BP0 A;  2W8G A;  2WN9 A;  2YME A;  4IL9 A;  3RIF A;  2BYQ A;  2W8F A;  3RQW A;  3JAD A;  3RQU A;  4F8H A;  4UM3 P;  1UX2 A;  5HEJ A;  4BQT A;  5KE4 A;  5AFN A;  3UU6 A;  2XNT A;  2BYS A;  4QH1 A;  4XHE A;  4COF A;  4LML A;  3C79 A;  2BYP A;  3EI0 A;  4ZR6 A;  5TVC A;  3P4W A;  2Y56 A;  4AFT A;  5BW2 A;  3JAE A;  5JME A;  3WTJ A;  2Y57 A;  4ZJT A;  2Y54 A;  4HFI A;  3PEO A;  3UQ7 A;  5HEU A;  5AFH A;  5AFM A;  4UM3 S;  2BG9 C;  2X00 D;  5AFM B;  3SQ9 A;  2XZ5 A;  3UU5 A;  2XQ3 A;  4QH5 A;  4DBM A;  4AFG A;  1UW6 A;  4ZZC A;  5HEG A;  5J0Z A;  4UXU A;  3ZDG A;  5J5I A;  5LXB A;  3IGQ A;  4HFH A;  5HCJ A;  3U8L A;  3WTL A;  3TLT A;  4B5D A;  5CO5 A;  3WTI A;  3ZKR A;  3ZDH A;  3PMZ A;  5HCM A;  2XYT A;  2C9T A;  4WV9 A;  3RI5 A;  2PGZ A;  4HQP A;  4A98 A;  2XNU A;  4NPP A;  2YN6 A;  2BR8 A;  3EAM A;  3WIP A;  4ZK1 A;  4ZZB A;  1I9B A;  2XYS A;  4PIR A;  4UY2 A;  2UZ6 A;  2PH9 A;  3SH1 A;  4TNV A;  4TWF A;  2YOE A;  2ZJV A;  1UV6 A;  2XNV A;  4LMK A;  3RHW A;  3WTM A;  2BG9 A;  2XQ4 A;  2VL0 A;  2XQ7 A;  3T4M A;  5IUX A;  3TLS A;  5J5H A;  2Y58 A;  2BG9 B;  2XQ9 A;  3JAF A;  5LG3 A;  4IRE A;  3LSV A;  2XQA A;  4Z90 A;  5AFJ A;  4ZJS A;  4FRR A;  2X00 A;  5AFK A;  3RIA A;  5AIN A;  2BYN A;  3C84 A;  2WZY A;  4TWD A;  5HEO A;  3EHZ A;  4ZK4 A;  4TWH A;  2BJ0 A;  2QC1 B;  2XQ6 A;  3WTK A;  4HFC A;  4ZRU A;  4QAC A;  3GUA A;  2XZ6 A;  3UU8 A;  3WTN A;  4ALX A;  4QAA A;  3U8J A;  5L47 A;  5KZU A;  3UU3 A;  4X5T A;  4D01 A;  5L4E A;  2WNC A;  4BFQ A;  4QH4 A;  2XQ5 A;  4UM1 A;  5SYO A;  2BR7 A;  2Y7Y A;  3P50 A;  3U8N A;  4HFB A;  4QAB A;  4NZB A;  5CFB A;  2BYR A;  3U8K A;  5J5F A;  3WTO A;  3TLV A;  4ILB A;  4HFD A;  2ZJU A;  2BG9 E;  4LMJ A;  2YKS A;  4AFH A;  3U8M A;  2YMD A;  4EZ1 A;  4HFE A;  2XQ8 A;  4ILA A;  3TLW A;  3SQ6 A;  5AFL A;  5FJV A;  3SIO A;  5J5G A;  3UUB A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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