5J5GA

X-ray crystal structure of acetylcholine binding protein (achbp) in complex with 6-(4-methoxyphenyl)-n4,n4-bis[(pyridin-2-yl)methyl]pyrimidine-2,4-diamine
Total Genus 55
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
55
sequence length
213
structure length
213
Chain Sequence
DYKDDDDKLDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLARVVSDGEVLYMPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTTENSDDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Substituted 2-Aminopyrimidines Selective for alpha 7-Nicotinic Acetylcholine Receptor Activation and Association with Acetylcholine Binding Proteins.
pubmed doi rcsb
molecule tags Acetylcholine-binding protein
source organism Lymnaea stagnalis
molecule keywords Acetylcholine-binding protein
total genus 55
structure length 213
sequence length 213
chains with identical sequence B, C, D, E, F, G, H, I, J
ec nomenclature
pdb deposition date 2016-04-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02931 Neur_chan_LBD Neurotransmitter-gated ion-channel ligand binding domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.170.10 Mainly Beta Distorted Sandwich Acetylcholine Binding Protein; Chain: A, Neurotransmitter-gated ion-channel ligand-binding domain 5j5gA00
5KE4A 5LXBA 3UQ4A 4QH1A 3JADA 4NZBA 2XQ3A 5BW2A 2YMEA 3U8LA 4AFHA 2WNJA 4UXUA 2W8FA 4LMLA 4XK9A 5CO5A 2Y7YA 3WTHA 4TWDA 5AFNA 4ZR6A 2XNUA 4TNVA 4X5TA 4XHEA 2BG9C 4EZ1A 3JAEA 5BP0A 2BG9E 2PGZA 3TLUA 5CFBA 3GUAA 4ZRUA 3SQ9A 3WTJA 5AFKA 4ILAA 2XQAA 3WTMA 4IREA 5HEJA 5L4EA 5FJVA 5JMEA 5KZUA 3UU5A 4TNWA 3ZDHA 4ZK4A 2XYSA 3RI5A 3UUBA 2WN9A 3TLVA 3EHZA 3EAMA 4IL9A 4QACA 3RQWA 4A97A 2BYQA 3PMZA 2XNVA 2XQ7A 3P4WA 2PH9A 5L4HA 2BJ0A 3JAFA 5J0ZA 2Y56A 4BQTA 2YMDA 5AFMB 3U8JA 4ZZBA 4F8HA 3RIFA 5AFMA 5AINA 2XQ9A 2XZ5A 3C84A 4TWFA 4UY2A 3ZDGA 3WTKA 2XNTA 4COFA 4BFQA 2UZ6A 3PEOA 3LSVA 2X00A 2BYPA 4HFDA 4ZK1A 5IUXA 2XYTA 3RQUA 3UQ7A 4LMJA 3UU4A 5J5HA 5AFJA 3WIPA 4QABA 4ILCA 3RHWA 2WNLA 2Y57A 3SQ6A 2BYSA 3UU3A 3RIAA 2ZJVA 4QH5A 3WTNA 2Y58A 3C79A 3TLWA 1I9BA 3WTOA 4UM1A 5LG3A 2BYRA 3U8MA 2WNCA 4UM3A 3WTIA 4PIRA 5HEGA 2VL0A 3P50A 3UU8A 3EI0A 3U8KA 5AFLA 2XQ6A 2YN6A 4B5DA 5AFHA 2QC1B 3T4MA 4NPPA 4D01A 3IGQA 4HFHA 4Z90A 5J5GA 3U8NA 5HEOA 1UV6A 4ZJTA 2XQ4A 4UM3P 5HCJA 5J5IA 2YOEA 3WTLA 5L47A 3SIOA 3TLTA 2BYNA 2BR7A 2XQ5A 4ILBA 4LMKA 4WV9A 4QH4A 4ALXA 4Z91A 2WZYA 5TVCA 4HFBA 4IL4A 2C9TA 2YKSA 4ZJSA 4AFGA 2XQ8A 5SYOA 2BG9B 4DBMA 4HQPA 4TWHA 4ZZCA 5BRXA 2BG9A 2W8GA 3UU6A 4HFEA 2BR8A 3ZKRA 2X00D 1UW6A 3TLSA 4QAAA 2Y54A 1UX2A 5J5FA 4HFIA 3SH1A 4HFCA 4A98A 4UM3S 2XZ6A 5HEUA 5HEHA 2ZJUA 5HCMA 4AFTA 4FRRA
chains in the Genus database with same CATH superfamily
5KE4A 5LXBA 3UQ4A 4QH1A 3JADA 4NZBA 2XQ3A 5BW2A 2YMEA 3U8LA 4AFHA 2WNJA 4UXUA 2W8FA 4LMLA 4XK9A 5CO5A 2Y7YA 3WTHA 4TWDA 5AFNA 4ZR6A 2XNUA 4TNVA 4X5TA 4XHEA 2BG9C 4EZ1A 3JAEA 5BP0A 2BG9E 2PGZA 3TLUA 5CFBA 3GUAA 4ZRUA 3SQ9A 3WTJA 5AFKA 4ILAA 2XQAA 3WTMA 4IREA 5HEJA 5L4EA 5FJVA 5JMEA 5KZUA 3UU5A 4TNWA 3ZDHA 4ZK4A 2XYSA 3RI5A 3UUBA 2WN9A 3TLVA 3EHZA 3EAMA 4IL9A 4QACA 3RQWA 4A97A 2BYQA 3PMZA 2XNVA 2XQ7A 3P4WA 2PH9A 5L4HA 2BJ0A 3JAFA 5J0ZA 2Y56A 4BQTA 2YMDA 5AFMB 3U8JA 4ZZBA 4F8HA 3RIFA 5AFMA 5AINA 2XQ9A 2XZ5A 3C84A 4TWFA 4UY2A 3ZDGA 3WTKA 2XNTA 4COFA 4BFQA 2UZ6A 3PEOA 3LSVA 2X00A 2BYPA 4HFDA 4ZK1A 5IUXA 2XYTA 3RQUA 3UQ7A 4LMJA 3UU4A 5J5HA 5AFJA 3WIPA 4QABA 4ILCA 3RHWA 2WNLA 2Y57A 3SQ6A 2BYSA 3UU3A 3RIAA 2ZJVA 4QH5A 3WTNA 2Y58A 3C79A 3TLWA 1I9BA 3WTOA 4UM1A 5LG3A 2BYRA 3U8MA 2WNCA 4UM3A 3WTIA 4PIRA 5HEGA 2VL0A 3P50A 3UU8A 3EI0A 3U8KA 5AFLA 2XQ6A 2YN6A 4B5DA 5AFHA 2QC1B 3T4MA 4NPPA 4D01A 3IGQA 4HFHA 4Z90A 5J5GA 3U8NA 5HEOA 1UV6A 4ZJTA 2XQ4A 4UM3P 5HCJA 5J5IA 2YOEA 3WTLA 5L47A 3SIOA 3TLTA 2BYNA 2BR7A 2XQ5A 4ILBA 4LMKA 4WV9A 4QH4A 4ALXA 4Z91A 2WZYA 5TVCA 4HFBA 4IL4A 2C9TA 2YKSA 4ZJSA 4AFGA 2XQ8A 5SYOA 2BG9B 4DBMA 4HQPA 4TWHA 4ZZCA 5BRXA 2BG9A 2W8GA 3UU6A 4HFEA 2BR8A 3ZKRA 2X00D 1UW6A 3TLSA 4QAAA 2Y54A 1UX2A 5J5FA 4HFIA 3SH1A 4HFCA 4A98A 4UM3S 2XZ6A 5HEUA 5HEHA 2ZJUA 5HCMA 4AFTA 4FRRA
chains in the Genus database with same CATH topology
5KE4A 5LXBA 3UQ4A 4QH1A 3JADA 4NZBA 2XQ3A 5BW2A 2YMEA 3U8LA 4AFHA 2WNJA 4UXUA 2W8FA 4LMLA 4XK9A 5CO5A 2Y7YA 3WTHA 4TWDA 5AFNA 4ZR6A 2XNUA 4TNVA 4X5TA 4XHEA 2BG9C 4EZ1A 3JAEA 5BP0A 2BG9E 2PGZA 3TLUA 5CFBA 3GUAA 4ZRUA 3SQ9A 3WTJA 5AFKA 4ILAA 2XQAA 3WTMA 4IREA 5HEJA 5L4EA 5FJVA 5JMEA 5KZUA 3UU5A 4TNWA 3ZDHA 4ZK4A 2XYSA 3RI5A 3UUBA 2WN9A 3TLVA 3EHZA 3EAMA 4IL9A 4QACA 3RQWA 4A97A 2BYQA 3PMZA 2XNVA 2XQ7A 3P4WA 2PH9A 5L4HA 2BJ0A 3JAFA 5J0ZA 2Y56A 4BQTA 2YMDA 5AFMB 3U8JA 4ZZBA 4F8HA 3RIFA 5AFMA 5AINA 2XQ9A 2XZ5A 3C84A 4TWFA 4UY2A 3ZDGA 3WTKA 2XNTA 4COFA 4BFQA 2UZ6A 3PEOA 3LSVA 2X00A 2BYPA 4HFDA 4ZK1A 5IUXA 2XYTA 3RQUA 3UQ7A 4LMJA 3UU4A 5J5HA 5AFJA 3WIPA 4QABA 4ILCA 3RHWA 2WNLA 2Y57A 3SQ6A 2BYSA 3UU3A 3RIAA 2ZJVA 4QH5A 3WTNA 2Y58A 3C79A 3TLWA 1I9BA 3WTOA 4UM1A 5LG3A 2BYRA 3U8MA 2WNCA 4UM3A 3WTIA 4PIRA 5HEGA 2VL0A 3P50A 3UU8A 3EI0A 3U8KA 5AFLA 2XQ6A 2YN6A 4B5DA 5AFHA 2QC1B 3T4MA 4NPPA 4D01A 3IGQA 4HFHA 4Z90A 5J5GA 3U8NA 5HEOA 1UV6A 4ZJTA 2XQ4A 4UM3P 5HCJA 5J5IA 2YOEA 3WTLA 5L47A 3SIOA 3TLTA 2BYNA 2BR7A 2XQ5A 4ILBA 4LMKA 4WV9A 4QH4A 4ALXA 4Z91A 2WZYA 5TVCA 4HFBA 4IL4A 2C9TA 2YKSA 4ZJSA 4AFGA 2XQ8A 5SYOA 2BG9B 4DBMA 4HQPA 4TWHA 4ZZCA 5BRXA 2BG9A 2W8GA 3UU6A 4HFEA 2BR8A 3ZKRA 2X00D 1UW6A 3TLSA 4QAAA 2Y54A 1UX2A 5J5FA 4HFIA 3SH1A 4HFCA 4A98A 4UM3S 2XZ6A 5HEUA 5HEHA 2ZJUA 5HCMA 4AFTA 4FRRA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5KE4 A;  5LXB A;  3UQ4 A;  4QH1 A;  3JAD A;  4NZB A;  2XQ3 A;  5BW2 A;  2YME A;  3U8L A;  4AFH A;  2WNJ A;  4UXU A;  2W8F A;  4LML A;  4XK9 A;  5CO5 A;  2Y7Y A;  3WTH A;  4TWD A;  5AFN A;  4ZR6 A;  2XNU A;  4TNV A;  4X5T A;  4XHE A;  2BG9 C;  4EZ1 A;  3JAE A;  5BP0 A;  2BG9 E;  2PGZ A;  3TLU A;  5CFB A;  3GUA A;  4ZRU A;  3SQ9 A;  3WTJ A;  5AFK A;  4ILA A;  2XQA A;  3WTM A;  4IRE A;  5HEJ A;  5L4E A;  5FJV A;  5JME A;  5KZU A;  3UU5 A;  4TNW A;  3ZDH A;  4ZK4 A;  2XYS A;  3RI5 A;  3UUB A;  2WN9 A;  3TLV A;  3EHZ A;  3EAM A;  4IL9 A;  4QAC A;  3RQW A;  4A97 A;  2BYQ A;  3PMZ A;  2XNV A;  2XQ7 A;  3P4W A;  2PH9 A;  5L4H A;  2BJ0 A;  3JAF A;  5J0Z A;  2Y56 A;  4BQT A;  2YMD A;  5AFM B;  3U8J A;  4ZZB A;  4F8H A;  3RIF A;  5AFM A;  5AIN A;  2XQ9 A;  2XZ5 A;  3C84 A;  4TWF A;  4UY2 A;  3ZDG A;  3WTK A;  2XNT A;  4COF A;  4BFQ A;  2UZ6 A;  3PEO A;  3LSV A;  2X00 A;  2BYP A;  4HFD A;  4ZK1 A;  5IUX A;  2XYT A;  3RQU A;  3UQ7 A;  4LMJ A;  3UU4 A;  5J5H A;  5AFJ A;  3WIP A;  4QAB A;  4ILC A;  3RHW A;  2WNL A;  2Y57 A;  3SQ6 A;  2BYS A;  3UU3 A;  3RIA A;  2ZJV A;  4QH5 A;  3WTN A;  2Y58 A;  3C79 A;  3TLW A;  1I9B A;  3WTO A;  4UM1 A;  5LG3 A;  2BYR A;  3U8M A;  2WNC A;  4UM3 A;  3WTI A;  4PIR A;  5HEG A;  2VL0 A;  3P50 A;  3UU8 A;  3EI0 A;  3U8K A;  5AFL A;  2XQ6 A;  2YN6 A;  4B5D A;  5AFH A;  2QC1 B;  3T4M A;  4NPP A;  4D01 A;  3IGQ A;  4HFH A;  4Z90 A;  5J5G A;  3U8N A;  5HEO A;  1UV6 A;  4ZJT A;  2XQ4 A;  4UM3 P;  5HCJ A;  5J5I A;  2YOE A;  3WTL A;  5L47 A;  3SIO A;  3TLT A;  2BYN A;  2BR7 A;  2XQ5 A;  4ILB A;  4LMK A;  4WV9 A;  4QH4 A;  4ALX A;  4Z91 A;  2WZY A;  5TVC A;  4HFB A;  4IL4 A;  2C9T A;  2YKS A;  4ZJS A;  4AFG A;  2XQ8 A;  5SYO A;  2BG9 B;  4DBM A;  4HQP A;  4TWH A;  4ZZC A;  5BRX A;  2BG9 A;  2W8G A;  3UU6 A;  4HFE A;  2BR8 A;  3ZKR A;  2X00 D;  1UW6 A;  3TLS A;  4QAA A;  2Y54 A;  1UX2 A;  5J5F A;  4HFI A;  3SH1 A;  4HFC A;  4A98 A;  4UM3 S;  2XZ6 A;  5HEU A;  5HEH A;  2ZJU A;  5HCM A;  4AFT A;  4FRR A; 
#chains in the Genus database with same CATH topology
 5KE4 A;  5LXB A;  3UQ4 A;  4QH1 A;  3JAD A;  4NZB A;  2XQ3 A;  5BW2 A;  2YME A;  3U8L A;  4AFH A;  2WNJ A;  4UXU A;  2W8F A;  4LML A;  4XK9 A;  5CO5 A;  2Y7Y A;  3WTH A;  4TWD A;  5AFN A;  4ZR6 A;  2XNU A;  4TNV A;  4X5T A;  4XHE A;  2BG9 C;  4EZ1 A;  3JAE A;  5BP0 A;  2BG9 E;  2PGZ A;  3TLU A;  5CFB A;  3GUA A;  4ZRU A;  3SQ9 A;  3WTJ A;  5AFK A;  4ILA A;  2XQA A;  3WTM A;  4IRE A;  5HEJ A;  5L4E A;  5FJV A;  5JME A;  5KZU A;  3UU5 A;  4TNW A;  3ZDH A;  4ZK4 A;  2XYS A;  3RI5 A;  3UUB A;  2WN9 A;  3TLV A;  3EHZ A;  3EAM A;  4IL9 A;  4QAC A;  3RQW A;  4A97 A;  2BYQ A;  3PMZ A;  2XNV A;  2XQ7 A;  3P4W A;  2PH9 A;  5L4H A;  2BJ0 A;  3JAF A;  5J0Z A;  2Y56 A;  4BQT A;  2YMD A;  5AFM B;  3U8J A;  4ZZB A;  4F8H A;  3RIF A;  5AFM A;  5AIN A;  2XQ9 A;  2XZ5 A;  3C84 A;  4TWF A;  4UY2 A;  3ZDG A;  3WTK A;  2XNT A;  4COF A;  4BFQ A;  2UZ6 A;  3PEO A;  3LSV A;  2X00 A;  2BYP A;  4HFD A;  4ZK1 A;  5IUX A;  2XYT A;  3RQU A;  3UQ7 A;  4LMJ A;  3UU4 A;  5J5H A;  5AFJ A;  3WIP A;  4QAB A;  4ILC A;  3RHW A;  2WNL A;  2Y57 A;  3SQ6 A;  2BYS A;  3UU3 A;  3RIA A;  2ZJV A;  4QH5 A;  3WTN A;  2Y58 A;  3C79 A;  3TLW A;  1I9B A;  3WTO A;  4UM1 A;  5LG3 A;  2BYR A;  3U8M A;  2WNC A;  4UM3 A;  3WTI A;  4PIR A;  5HEG A;  2VL0 A;  3P50 A;  3UU8 A;  3EI0 A;  3U8K A;  5AFL A;  2XQ6 A;  2YN6 A;  4B5D A;  5AFH A;  2QC1 B;  3T4M A;  4NPP A;  4D01 A;  3IGQ A;  4HFH A;  4Z90 A;  5J5G A;  3U8N A;  5HEO A;  1UV6 A;  4ZJT A;  2XQ4 A;  4UM3 P;  5HCJ A;  5J5I A;  2YOE A;  3WTL A;  5L47 A;  3SIO A;  3TLT A;  2BYN A;  2BR7 A;  2XQ5 A;  4ILB A;  4LMK A;  4WV9 A;  4QH4 A;  4ALX A;  4Z91 A;  2WZY A;  5TVC A;  4HFB A;  4IL4 A;  2C9T A;  2YKS A;  4ZJS A;  4AFG A;  2XQ8 A;  5SYO A;  2BG9 B;  4DBM A;  4HQP A;  4TWH A;  4ZZC A;  5BRX A;  2BG9 A;  2W8G A;  3UU6 A;  4HFE A;  2BR8 A;  3ZKR A;  2X00 D;  1UW6 A;  3TLS A;  4QAA A;  2Y54 A;  1UX2 A;  5J5F A;  4HFI A;  3SH1 A;  4HFC A;  4A98 A;  4UM3 S;  2XZ6 A;  5HEU A;  5HEH A;  2ZJU A;  5HCM A;  4AFT A;  4FRR A; 
#chains in the Genus database with same CATH homology
 5KE4 A;  5LXB A;  3UQ4 A;  4QH1 A;  3JAD A;  4NZB A;  2XQ3 A;  5BW2 A;  2YME A;  3U8L A;  4AFH A;  2WNJ A;  4UXU A;  2W8F A;  4LML A;  4XK9 A;  5CO5 A;  2Y7Y A;  3WTH A;  4TWD A;  5AFN A;  4ZR6 A;  2XNU A;  4TNV A;  4X5T A;  4XHE A;  2BG9 C;  4EZ1 A;  3JAE A;  5BP0 A;  2BG9 E;  2PGZ A;  3TLU A;  5CFB A;  3GUA A;  4ZRU A;  3SQ9 A;  3WTJ A;  5AFK A;  4ILA A;  2XQA A;  3WTM A;  4IRE A;  5HEJ A;  5L4E A;  5FJV A;  5JME A;  5KZU A;  3UU5 A;  4TNW A;  3ZDH A;  4ZK4 A;  2XYS A;  3RI5 A;  3UUB A;  2WN9 A;  3TLV A;  3EHZ A;  3EAM A;  4IL9 A;  4QAC A;  3RQW A;  4A97 A;  2BYQ A;  3PMZ A;  2XNV A;  2XQ7 A;  3P4W A;  2PH9 A;  5L4H A;  2BJ0 A;  3JAF A;  5J0Z A;  2Y56 A;  4BQT A;  2YMD A;  5AFM B;  3U8J A;  4ZZB A;  4F8H A;  3RIF A;  5AFM A;  5AIN A;  2XQ9 A;  2XZ5 A;  3C84 A;  4TWF A;  4UY2 A;  3ZDG A;  3WTK A;  2XNT A;  4COF A;  4BFQ A;  2UZ6 A;  3PEO A;  3LSV A;  2X00 A;  2BYP A;  4HFD A;  4ZK1 A;  5IUX A;  2XYT A;  3RQU A;  3UQ7 A;  4LMJ A;  3UU4 A;  5J5H A;  5AFJ A;  3WIP A;  4QAB A;  4ILC A;  3RHW A;  2WNL A;  2Y57 A;  3SQ6 A;  2BYS A;  3UU3 A;  3RIA A;  2ZJV A;  4QH5 A;  3WTN A;  2Y58 A;  3C79 A;  3TLW A;  1I9B A;  3WTO A;  4UM1 A;  5LG3 A;  2BYR A;  3U8M A;  2WNC A;  4UM3 A;  3WTI A;  4PIR A;  5HEG A;  2VL0 A;  3P50 A;  3UU8 A;  3EI0 A;  3U8K A;  5AFL A;  2XQ6 A;  2YN6 A;  4B5D A;  5AFH A;  2QC1 B;  3T4M A;  4NPP A;  4D01 A;  3IGQ A;  4HFH A;  4Z90 A;  5J5G A;  3U8N A;  5HEO A;  1UV6 A;  4ZJT A;  2XQ4 A;  4UM3 P;  5HCJ A;  5J5I A;  2YOE A;  3WTL A;  5L47 A;  3SIO A;  3TLT A;  2BYN A;  2BR7 A;  2XQ5 A;  4ILB A;  4LMK A;  4WV9 A;  4QH4 A;  4ALX A;  4Z91 A;  2WZY A;  5TVC A;  4HFB A;  4IL4 A;  2C9T A;  2YKS A;  4ZJS A;  4AFG A;  2XQ8 A;  5SYO A;  2BG9 B;  4DBM A;  4HQP A;  4TWH A;  4ZZC A;  5BRX A;  2BG9 A;  2W8G A;  3UU6 A;  4HFE A;  2BR8 A;  3ZKR A;  2X00 D;  1UW6 A;  3TLS A;  4QAA A;  2Y54 A;  1UX2 A;  5J5F A;  4HFI A;  3SH1 A;  4HFC A;  4A98 A;  4UM3 S;  2XZ6 A;  5HEU A;  5HEH A;  2ZJU A;  5HCM A;  4AFT A;  4FRR A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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