5J5IA

X-ray crystal structure of acetylcholine binding protein (achbp) in complex with 4-(2-amino-6-{bis[(pyridin-2-yl)methyl]amino}pyrimidin-4-yl)phenol
Total Genus 51
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
51
sequence length
213
structure length
213
Chain Sequence
DYKDDDDKLDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLARVVSDGEVLYMPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTTENSDDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Substituted 2-Aminopyrimidines Selective for alpha 7-Nicotinic Acetylcholine Receptor Activation and Association with Acetylcholine Binding Proteins.
pubmed doi rcsb
molecule tags Acetylcholine-binding protein, achbp
source organism Lymnaea stagnalis
molecule keywords Acetylcholine-binding protein
total genus 51
structure length 213
sequence length 213
chains with identical sequence B, C, D, E, F, G, H, I, J
ec nomenclature
pdb deposition date 2016-04-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02931 Neur_chan_LBD Neurotransmitter-gated ion-channel ligand binding domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.170.10 Mainly Beta Distorted Sandwich Acetylcholine Binding Protein; Chain: A, Neurotransmitter-gated ion-channel ligand-binding domain 5j5iA00
4WV9A 3UU8A 4HFDA 4HQPA 4UY2A 3LSVA 5AFMA 5BW2A 4A98A 5HEGA 4A97A 3WTHA 2YKSA 4ZZBA 4UXUA 4NPPA 4UM3A 3U8MA 3EI0A 5L4EA 5AINA 2XZ6A 3U8LA 1UV6A 4BQTA 3ZDGA 5AFHA 4LMLA 2QC1B 2Y56A 3C84A 4TWFA 5CO5A 5KE4A 4QH4A 2WNCA 2YN6A 2XQ8A 3EHZA 3TLWA 4AFHA 5J0ZA 2WN9A 4Z91A 5AFKA 3JAFA 3WTMA 2XQ5A 5LG3A 2BJ0A 2XQ7A 4TNVA 3RI5A 3U8JA 2XNUA 4AFTA 2Y57A 5HEHA 3PEOA 2BG9A 3U8NA 4ZZCA 3ZKRA 4X5TA 2PGZA 5LXBA 5HCMA 2VL0A 4LMJA 5AFNA 4UM3P 3WTKA 3P4WA 3UU3A 5JMEA 5AFJA 2BYSA 2BG9B 5BRXA 4Z90A 5SYOA 2BR7A 2Y7YA 2BYQA 5AFMB 2YMEA 3EAMA 5KZUA 4EZ1A 2BG9C 4LMKA 4NZBA 2XYTA 1UX2A 2WNLA 2ZJVA 1I9BA 4TWDA 4ZK4A 3RIAA 4QABA 2BG9E 3WTLA 3JADA 4TNWA 5L4HA 5IUXA 2W8GA 2XNVA 3IGQA 4ZRUA 2XQ6A 2XQ4A 4ILAA 4BFQA 3PMZA 3ZDHA 2C9TA 2BYPA 3SQ9A 4DBMA 4COFA 2ZJUA 5HEJA 4IL9A 2BYNA 3UUBA 2YMDA 1UW6A 2XZ5A 2XYSA 3P50A 4HFHA 5FJVA 4QH1A 2WNJA 4XHEA 2Y58A 4HFEA 4ILCA 5J5HA 5CFBA 4ILBA 3UQ4A 3WIPA 4TWHA 4D01A 2YOEA 2XQAA 3WTNA 5TVCA 2XNTA 4IL4A 2X00A 5L47A 2W8FA 4XK9A 3U8KA 4FRRA 3WTOA 2XQ3A 4PIRA 2WZYA 4IREA 3RQWA 4HFIA 3RQUA 4ZR6A 4ZJTA 2Y54A 5J5GA 2X00D 4ZK1A 3T4MA 3RHWA 3TLSA 3TLVA 2BYRA 5HEOA 4UM3S 5BP0A 3SQ6A 5J5FA 3RIFA 4ALXA 4HFBA 3UU5A 3TLUA 5AFLA 3C79A 3GUAA 4QACA 3SIOA 5HEUA 4HFCA 2XQ9A 3UU4A 2PH9A 4F8HA 3JAEA 3UU6A 4ZJSA 3TLTA 5HCJA 4QAAA 4QH5A 2UZ6A 4AFGA 3SH1A 3WTJA 5J5IA 2BR8A 4UM1A 4B5DA 3UQ7A 3WTIA
chains in the Genus database with same CATH superfamily
4WV9A 3UU8A 4HFDA 4HQPA 4UY2A 3LSVA 5AFMA 5BW2A 4A98A 5HEGA 4A97A 3WTHA 2YKSA 4ZZBA 4UXUA 4NPPA 4UM3A 3U8MA 3EI0A 5L4EA 5AINA 2XZ6A 3U8LA 1UV6A 4BQTA 3ZDGA 5AFHA 4LMLA 2QC1B 2Y56A 3C84A 4TWFA 5CO5A 5KE4A 4QH4A 2WNCA 2YN6A 2XQ8A 3EHZA 3TLWA 4AFHA 5J0ZA 2WN9A 4Z91A 5AFKA 3JAFA 3WTMA 2XQ5A 5LG3A 2BJ0A 2XQ7A 4TNVA 3RI5A 3U8JA 2XNUA 4AFTA 2Y57A 5HEHA 3PEOA 2BG9A 3U8NA 4ZZCA 3ZKRA 4X5TA 2PGZA 5LXBA 5HCMA 2VL0A 4LMJA 5AFNA 4UM3P 3WTKA 3P4WA 3UU3A 5JMEA 5AFJA 2BYSA 2BG9B 5BRXA 4Z90A 5SYOA 2BR7A 2Y7YA 2BYQA 5AFMB 2YMEA 3EAMA 5KZUA 4EZ1A 2BG9C 4LMKA 4NZBA 2XYTA 1UX2A 2WNLA 2ZJVA 1I9BA 4TWDA 4ZK4A 3RIAA 4QABA 2BG9E 3WTLA 3JADA 4TNWA 5L4HA 5IUXA 2W8GA 2XNVA 3IGQA 4ZRUA 2XQ6A 2XQ4A 4ILAA 4BFQA 3PMZA 3ZDHA 2C9TA 2BYPA 3SQ9A 4DBMA 4COFA 2ZJUA 5HEJA 4IL9A 2BYNA 3UUBA 2YMDA 1UW6A 2XZ5A 2XYSA 3P50A 4HFHA 5FJVA 4QH1A 2WNJA 4XHEA 2Y58A 4HFEA 4ILCA 5J5HA 5CFBA 4ILBA 3UQ4A 3WIPA 4TWHA 4D01A 2YOEA 2XQAA 3WTNA 5TVCA 2XNTA 4IL4A 2X00A 5L47A 2W8FA 4XK9A 3U8KA 4FRRA 3WTOA 2XQ3A 4PIRA 2WZYA 4IREA 3RQWA 4HFIA 3RQUA 4ZR6A 4ZJTA 2Y54A 5J5GA 2X00D 4ZK1A 3T4MA 3RHWA 3TLSA 3TLVA 2BYRA 5HEOA 4UM3S 5BP0A 3SQ6A 5J5FA 3RIFA 4ALXA 4HFBA 3UU5A 3TLUA 5AFLA 3C79A 3GUAA 4QACA 3SIOA 5HEUA 4HFCA 2XQ9A 3UU4A 2PH9A 4F8HA 3JAEA 3UU6A 4ZJSA 3TLTA 5HCJA 4QAAA 4QH5A 2UZ6A 4AFGA 3SH1A 3WTJA 5J5IA 2BR8A 4UM1A 4B5DA 3UQ7A 3WTIA
chains in the Genus database with same CATH topology
4WV9A 3UU8A 4HFDA 4HQPA 4UY2A 3LSVA 5AFMA 5BW2A 4A98A 5HEGA 4A97A 3WTHA 2YKSA 4ZZBA 4UXUA 4NPPA 4UM3A 3U8MA 3EI0A 5L4EA 5AINA 2XZ6A 3U8LA 1UV6A 4BQTA 3ZDGA 5AFHA 4LMLA 2QC1B 2Y56A 3C84A 4TWFA 5CO5A 5KE4A 4QH4A 2WNCA 2YN6A 2XQ8A 3EHZA 3TLWA 4AFHA 5J0ZA 2WN9A 4Z91A 5AFKA 3JAFA 3WTMA 2XQ5A 5LG3A 2BJ0A 2XQ7A 4TNVA 3RI5A 3U8JA 2XNUA 4AFTA 2Y57A 5HEHA 3PEOA 2BG9A 3U8NA 4ZZCA 3ZKRA 4X5TA 2PGZA 5LXBA 5HCMA 2VL0A 4LMJA 5AFNA 4UM3P 3WTKA 3P4WA 3UU3A 5JMEA 5AFJA 2BYSA 2BG9B 5BRXA 4Z90A 5SYOA 2BR7A 2Y7YA 2BYQA 5AFMB 2YMEA 3EAMA 5KZUA 4EZ1A 2BG9C 4LMKA 4NZBA 2XYTA 1UX2A 2WNLA 2ZJVA 1I9BA 4TWDA 4ZK4A 3RIAA 4QABA 2BG9E 3WTLA 3JADA 4TNWA 5L4HA 5IUXA 2W8GA 2XNVA 3IGQA 4ZRUA 2XQ6A 2XQ4A 4ILAA 4BFQA 3PMZA 3ZDHA 2C9TA 2BYPA 3SQ9A 4DBMA 4COFA 2ZJUA 5HEJA 4IL9A 2BYNA 3UUBA 2YMDA 1UW6A 2XZ5A 2XYSA 3P50A 4HFHA 5FJVA 4QH1A 2WNJA 4XHEA 2Y58A 4HFEA 4ILCA 5J5HA 5CFBA 4ILBA 3UQ4A 3WIPA 4TWHA 4D01A 2YOEA 2XQAA 3WTNA 5TVCA 2XNTA 4IL4A 2X00A 5L47A 2W8FA 4XK9A 3U8KA 4FRRA 3WTOA 2XQ3A 4PIRA 2WZYA 4IREA 3RQWA 4HFIA 3RQUA 4ZR6A 4ZJTA 2Y54A 5J5GA 2X00D 4ZK1A 3T4MA 3RHWA 3TLSA 3TLVA 2BYRA 5HEOA 4UM3S 5BP0A 3SQ6A 5J5FA 3RIFA 4ALXA 4HFBA 3UU5A 3TLUA 5AFLA 3C79A 3GUAA 4QACA 3SIOA 5HEUA 4HFCA 2XQ9A 3UU4A 2PH9A 4F8HA 3JAEA 3UU6A 4ZJSA 3TLTA 5HCJA 4QAAA 4QH5A 2UZ6A 4AFGA 3SH1A 3WTJA 5J5IA 2BR8A 4UM1A 4B5DA 3UQ7A 3WTIA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4WV9 A;  3UU8 A;  4HFD A;  4HQP A;  4UY2 A;  3LSV A;  5AFM A;  5BW2 A;  4A98 A;  5HEG A;  4A97 A;  3WTH A;  2YKS A;  4ZZB A;  4UXU A;  4NPP A;  4UM3 A;  3U8M A;  3EI0 A;  5L4E A;  5AIN A;  2XZ6 A;  3U8L A;  1UV6 A;  4BQT A;  3ZDG A;  5AFH A;  4LML A;  2QC1 B;  2Y56 A;  3C84 A;  4TWF A;  5CO5 A;  5KE4 A;  4QH4 A;  2WNC A;  2YN6 A;  2XQ8 A;  3EHZ A;  3TLW A;  4AFH A;  5J0Z A;  2WN9 A;  4Z91 A;  5AFK A;  3JAF A;  3WTM A;  2XQ5 A;  5LG3 A;  2BJ0 A;  2XQ7 A;  4TNV A;  3RI5 A;  3U8J A;  2XNU A;  4AFT A;  2Y57 A;  5HEH A;  3PEO A;  2BG9 A;  3U8N A;  4ZZC A;  3ZKR A;  4X5T A;  2PGZ A;  5LXB A;  5HCM A;  2VL0 A;  4LMJ A;  5AFN A;  4UM3 P;  3WTK A;  3P4W A;  3UU3 A;  5JME A;  5AFJ A;  2BYS A;  2BG9 B;  5BRX A;  4Z90 A;  5SYO A;  2BR7 A;  2Y7Y A;  2BYQ A;  5AFM B;  2YME A;  3EAM A;  5KZU A;  4EZ1 A;  2BG9 C;  4LMK A;  4NZB A;  2XYT A;  1UX2 A;  2WNL A;  2ZJV A;  1I9B A;  4TWD A;  4ZK4 A;  3RIA A;  4QAB A;  2BG9 E;  3WTL A;  3JAD A;  4TNW A;  5L4H A;  5IUX A;  2W8G A;  2XNV A;  3IGQ A;  4ZRU A;  2XQ6 A;  2XQ4 A;  4ILA A;  4BFQ A;  3PMZ A;  3ZDH A;  2C9T A;  2BYP A;  3SQ9 A;  4DBM A;  4COF A;  2ZJU A;  5HEJ A;  4IL9 A;  2BYN A;  3UUB A;  2YMD A;  1UW6 A;  2XZ5 A;  2XYS A;  3P50 A;  4HFH A;  5FJV A;  4QH1 A;  2WNJ A;  4XHE A;  2Y58 A;  4HFE A;  4ILC A;  5J5H A;  5CFB A;  4ILB A;  3UQ4 A;  3WIP A;  4TWH A;  4D01 A;  2YOE A;  2XQA A;  3WTN A;  5TVC A;  2XNT A;  4IL4 A;  2X00 A;  5L47 A;  2W8F A;  4XK9 A;  3U8K A;  4FRR A;  3WTO A;  2XQ3 A;  4PIR A;  2WZY A;  4IRE A;  3RQW A;  4HFI A;  3RQU A;  4ZR6 A;  4ZJT A;  2Y54 A;  5J5G A;  2X00 D;  4ZK1 A;  3T4M A;  3RHW A;  3TLS A;  3TLV A;  2BYR A;  5HEO A;  4UM3 S;  5BP0 A;  3SQ6 A;  5J5F A;  3RIF A;  4ALX A;  4HFB A;  3UU5 A;  3TLU A;  5AFL A;  3C79 A;  3GUA A;  4QAC A;  3SIO A;  5HEU A;  4HFC A;  2XQ9 A;  3UU4 A;  2PH9 A;  4F8H A;  3JAE A;  3UU6 A;  4ZJS A;  3TLT A;  5HCJ A;  4QAA A;  4QH5 A;  2UZ6 A;  4AFG A;  3SH1 A;  3WTJ A;  5J5I A;  2BR8 A;  4UM1 A;  4B5D A;  3UQ7 A;  3WTI A; 
#chains in the Genus database with same CATH topology
 4WV9 A;  3UU8 A;  4HFD A;  4HQP A;  4UY2 A;  3LSV A;  5AFM A;  5BW2 A;  4A98 A;  5HEG A;  4A97 A;  3WTH A;  2YKS A;  4ZZB A;  4UXU A;  4NPP A;  4UM3 A;  3U8M A;  3EI0 A;  5L4E A;  5AIN A;  2XZ6 A;  3U8L A;  1UV6 A;  4BQT A;  3ZDG A;  5AFH A;  4LML A;  2QC1 B;  2Y56 A;  3C84 A;  4TWF A;  5CO5 A;  5KE4 A;  4QH4 A;  2WNC A;  2YN6 A;  2XQ8 A;  3EHZ A;  3TLW A;  4AFH A;  5J0Z A;  2WN9 A;  4Z91 A;  5AFK A;  3JAF A;  3WTM A;  2XQ5 A;  5LG3 A;  2BJ0 A;  2XQ7 A;  4TNV A;  3RI5 A;  3U8J A;  2XNU A;  4AFT A;  2Y57 A;  5HEH A;  3PEO A;  2BG9 A;  3U8N A;  4ZZC A;  3ZKR A;  4X5T A;  2PGZ A;  5LXB A;  5HCM A;  2VL0 A;  4LMJ A;  5AFN A;  4UM3 P;  3WTK A;  3P4W A;  3UU3 A;  5JME A;  5AFJ A;  2BYS A;  2BG9 B;  5BRX A;  4Z90 A;  5SYO A;  2BR7 A;  2Y7Y A;  2BYQ A;  5AFM B;  2YME A;  3EAM A;  5KZU A;  4EZ1 A;  2BG9 C;  4LMK A;  4NZB A;  2XYT A;  1UX2 A;  2WNL A;  2ZJV A;  1I9B A;  4TWD A;  4ZK4 A;  3RIA A;  4QAB A;  2BG9 E;  3WTL A;  3JAD A;  4TNW A;  5L4H A;  5IUX A;  2W8G A;  2XNV A;  3IGQ A;  4ZRU A;  2XQ6 A;  2XQ4 A;  4ILA A;  4BFQ A;  3PMZ A;  3ZDH A;  2C9T A;  2BYP A;  3SQ9 A;  4DBM A;  4COF A;  2ZJU A;  5HEJ A;  4IL9 A;  2BYN A;  3UUB A;  2YMD A;  1UW6 A;  2XZ5 A;  2XYS A;  3P50 A;  4HFH A;  5FJV A;  4QH1 A;  2WNJ A;  4XHE A;  2Y58 A;  4HFE A;  4ILC A;  5J5H A;  5CFB A;  4ILB A;  3UQ4 A;  3WIP A;  4TWH A;  4D01 A;  2YOE A;  2XQA A;  3WTN A;  5TVC A;  2XNT A;  4IL4 A;  2X00 A;  5L47 A;  2W8F A;  4XK9 A;  3U8K A;  4FRR A;  3WTO A;  2XQ3 A;  4PIR A;  2WZY A;  4IRE A;  3RQW A;  4HFI A;  3RQU A;  4ZR6 A;  4ZJT A;  2Y54 A;  5J5G A;  2X00 D;  4ZK1 A;  3T4M A;  3RHW A;  3TLS A;  3TLV A;  2BYR A;  5HEO A;  4UM3 S;  5BP0 A;  3SQ6 A;  5J5F A;  3RIF A;  4ALX A;  4HFB A;  3UU5 A;  3TLU A;  5AFL A;  3C79 A;  3GUA A;  4QAC A;  3SIO A;  5HEU A;  4HFC A;  2XQ9 A;  3UU4 A;  2PH9 A;  4F8H A;  3JAE A;  3UU6 A;  4ZJS A;  3TLT A;  5HCJ A;  4QAA A;  4QH5 A;  2UZ6 A;  4AFG A;  3SH1 A;  3WTJ A;  5J5I A;  2BR8 A;  4UM1 A;  4B5D A;  3UQ7 A;  3WTI A; 
#chains in the Genus database with same CATH homology
 4WV9 A;  3UU8 A;  4HFD A;  4HQP A;  4UY2 A;  3LSV A;  5AFM A;  5BW2 A;  4A98 A;  5HEG A;  4A97 A;  3WTH A;  2YKS A;  4ZZB A;  4UXU A;  4NPP A;  4UM3 A;  3U8M A;  3EI0 A;  5L4E A;  5AIN A;  2XZ6 A;  3U8L A;  1UV6 A;  4BQT A;  3ZDG A;  5AFH A;  4LML A;  2QC1 B;  2Y56 A;  3C84 A;  4TWF A;  5CO5 A;  5KE4 A;  4QH4 A;  2WNC A;  2YN6 A;  2XQ8 A;  3EHZ A;  3TLW A;  4AFH A;  5J0Z A;  2WN9 A;  4Z91 A;  5AFK A;  3JAF A;  3WTM A;  2XQ5 A;  5LG3 A;  2BJ0 A;  2XQ7 A;  4TNV A;  3RI5 A;  3U8J A;  2XNU A;  4AFT A;  2Y57 A;  5HEH A;  3PEO A;  2BG9 A;  3U8N A;  4ZZC A;  3ZKR A;  4X5T A;  2PGZ A;  5LXB A;  5HCM A;  2VL0 A;  4LMJ A;  5AFN A;  4UM3 P;  3WTK A;  3P4W A;  3UU3 A;  5JME A;  5AFJ A;  2BYS A;  2BG9 B;  5BRX A;  4Z90 A;  5SYO A;  2BR7 A;  2Y7Y A;  2BYQ A;  5AFM B;  2YME A;  3EAM A;  5KZU A;  4EZ1 A;  2BG9 C;  4LMK A;  4NZB A;  2XYT A;  1UX2 A;  2WNL A;  2ZJV A;  1I9B A;  4TWD A;  4ZK4 A;  3RIA A;  4QAB A;  2BG9 E;  3WTL A;  3JAD A;  4TNW A;  5L4H A;  5IUX A;  2W8G A;  2XNV A;  3IGQ A;  4ZRU A;  2XQ6 A;  2XQ4 A;  4ILA A;  4BFQ A;  3PMZ A;  3ZDH A;  2C9T A;  2BYP A;  3SQ9 A;  4DBM A;  4COF A;  2ZJU A;  5HEJ A;  4IL9 A;  2BYN A;  3UUB A;  2YMD A;  1UW6 A;  2XZ5 A;  2XYS A;  3P50 A;  4HFH A;  5FJV A;  4QH1 A;  2WNJ A;  4XHE A;  2Y58 A;  4HFE A;  4ILC A;  5J5H A;  5CFB A;  4ILB A;  3UQ4 A;  3WIP A;  4TWH A;  4D01 A;  2YOE A;  2XQA A;  3WTN A;  5TVC A;  2XNT A;  4IL4 A;  2X00 A;  5L47 A;  2W8F A;  4XK9 A;  3U8K A;  4FRR A;  3WTO A;  2XQ3 A;  4PIR A;  2WZY A;  4IRE A;  3RQW A;  4HFI A;  3RQU A;  4ZR6 A;  4ZJT A;  2Y54 A;  5J5G A;  2X00 D;  4ZK1 A;  3T4M A;  3RHW A;  3TLS A;  3TLV A;  2BYR A;  5HEO A;  4UM3 S;  5BP0 A;  3SQ6 A;  5J5F A;  3RIF A;  4ALX A;  4HFB A;  3UU5 A;  3TLU A;  5AFL A;  3C79 A;  3GUA A;  4QAC A;  3SIO A;  5HEU A;  4HFC A;  2XQ9 A;  3UU4 A;  2PH9 A;  4F8H A;  3JAE A;  3UU6 A;  4ZJS A;  3TLT A;  5HCJ A;  4QAA A;  4QH5 A;  2UZ6 A;  4AFG A;  3SH1 A;  3WTJ A;  5J5I A;  2BR8 A;  4UM1 A;  4B5D A;  3UQ7 A;  3WTI A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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