5LXBA

Crystal structure of a mutant binding protein (5htbp-achbp) in complex with palonosetron
Total Genus 49
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
49
sequence length
205
structure length
205
Chain Sequence
QANLMRLKSDLFNRSPMYPGPTKDDPLTVTLGFTLQDIVKVDSSTNEVDLVYWERQRWKLNSLMWDPNEYGNITDFRTSAADIWTPDITAYSSTRPVQVLSPQIAVVTHDGSVMFIPAQRLSFMCDPTGVDSEEGVTCAVKFGSWVYSGFEIDLKTDTDQVDLSSYYASSKYEILSATQTRQVQHYSCCPEPYIDVNLVVKFRER
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title Palonosetron-5-HT3 Receptor Interactions As Shown by a Binding Protein Cocrystal Structure.
pubmed doi rcsb
molecule tags Acetylcholine binding protein
source organism Aplysia californica
molecule keywords Soluble acetylcholine receptor
total genus 49
structure length 205
sequence length 205
chains with identical sequence B, C, D, E, F, G, H, I, J
ec nomenclature
pdb deposition date 2016-09-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02931 Neur_chan_LBD Neurotransmitter-gated ion-channel ligand binding domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.170.10 Mainly Beta Distorted Sandwich Acetylcholine Binding Protein; Chain: A, Neurotransmitter-gated ion-channel ligand-binding domain 5lxbA00
4ZR6A 3TLUA 3GUAA 4HFEA 2XQ3A 2WNJA 3SIOA 2Y56A 3UU6A 4NPPA 4QABA 2BYPA 5L47A 2XQ5A 2UZ6A 2BJ0A 2X00D 2XQAA 3WTIA 3ZDGA 4ILBA 4ALXA 4COFA 2XYSA 3P4WA 5CO5A 5HEOA 3TLWA 5AFMB 2XQ6A 4ILAA 4TNVA 3WTKA 3SQ6A 4UXUA 4EZ1A 4ZZCA 3U8KA 3IGQA 4UY2A 3P50A 4DBMA 4UM3S 2WNCA 2XNUA 2BR8A 4X5TA 4QH4A 3U8NA 2BG9E 4QH1A 2XYTA 2XQ9A 2Y57A 4FRRA 5JMEA 2XNVA 4HFCA 4IREA 4HFIA 4ZK4A 5AFMA 3EI0A 2BYSA 2VL0A 4QAAA 3WTLA 5BW2A 3U8JA 3PMZA 4IL4A 3WTOA 4D01A 2C9TA 2WZYA 4ILCA 2XQ4A 3RHWA 2XZ5A 4UM1A 4ZJTA 5TVCA 3C84A 2QC1B 5AFNA 4TNWA 3RIAA 5HEUA 3WTHA 4XHEA 2XQ7A 5HCMA 5J0ZA 1UV6A 5AFLA 2ZJVA 4QH5A 3ZDHA 5LXBA 4UM3P 4Z90A 4TWDA 3WTNA 2Y58A 5IUXA 4LMJA 2YN6A 2XQ8A 3UU3A 5HEHA 4ZZBA 4ZK1A 2BG9B 3PEOA 3JAEA 5J5GA 2PGZA 4UM3A 4NZBA 2WN9A 5HCJA 4PIRA 4ZJSA 2X00A 2XNTA 3RI5A 3SH1A 5CFBA 5KE4A 5L4EA 2BG9C 4LMLA 5AINA 3U8MA 5KZUA 4TWFA 3UUBA 3TLSA 2YMDA 2W8FA 4LMKA 3T4MA 5HEJA 5J5HA 4XK9A 3JADA 4HFBA 3UQ7A 4B5DA 5BRXA 3LSVA 4Z91A 1UX2A 4WV9A 2YOEA 5L4HA 2YMEA 3UU8A 5AFJA 5AFKA 5J5IA 4BFQA 4HFDA 2Y7YA 4AFTA 2W8GA 3SQ9A 5HEGA 3C79A 3UU4A 4A97A 5J5FA 4AFGA 4HFHA 3EAMA 3U8LA 2BYNA 4BQTA 1UW6A 4IL9A 2PH9A 4F8HA 3WTMA 2BYQA 3ZKRA 3RQWA 5BP0A 3TLTA 2BR7A 4TWHA 2ZJUA 4AFHA 4A98A 5SYOA 2XZ6A 4HQPA 3WIPA 3WTJA 1I9BA 2BYRA 4QACA 3UU5A 2YKSA 3RQUA 3TLVA 2WNLA 3EHZA 2BG9A 3RIFA 3JAFA 3UQ4A 5FJVA 2Y54A 5LG3A 4ZRUA 5AFHA
chains in the Genus database with same CATH superfamily
4ZR6A 3TLUA 3GUAA 4HFEA 2XQ3A 2WNJA 3SIOA 2Y56A 3UU6A 4NPPA 4QABA 2BYPA 5L47A 2XQ5A 2UZ6A 2BJ0A 2X00D 2XQAA 3WTIA 3ZDGA 4ILBA 4ALXA 4COFA 2XYSA 3P4WA 5CO5A 5HEOA 3TLWA 5AFMB 2XQ6A 4ILAA 4TNVA 3WTKA 3SQ6A 4UXUA 4EZ1A 4ZZCA 3U8KA 3IGQA 4UY2A 3P50A 4DBMA 4UM3S 2WNCA 2XNUA 2BR8A 4X5TA 4QH4A 3U8NA 2BG9E 4QH1A 2XYTA 2XQ9A 2Y57A 4FRRA 5JMEA 2XNVA 4HFCA 4IREA 4HFIA 4ZK4A 5AFMA 3EI0A 2BYSA 2VL0A 4QAAA 3WTLA 5BW2A 3U8JA 3PMZA 4IL4A 3WTOA 4D01A 2C9TA 2WZYA 4ILCA 2XQ4A 3RHWA 2XZ5A 4UM1A 4ZJTA 5TVCA 3C84A 2QC1B 5AFNA 4TNWA 3RIAA 5HEUA 3WTHA 4XHEA 2XQ7A 5HCMA 5J0ZA 1UV6A 5AFLA 2ZJVA 4QH5A 3ZDHA 5LXBA 4UM3P 4Z90A 4TWDA 3WTNA 2Y58A 5IUXA 4LMJA 2YN6A 2XQ8A 3UU3A 5HEHA 4ZZBA 4ZK1A 2BG9B 3PEOA 3JAEA 5J5GA 2PGZA 4UM3A 4NZBA 2WN9A 5HCJA 4PIRA 4ZJSA 2X00A 2XNTA 3RI5A 3SH1A 5CFBA 5KE4A 5L4EA 2BG9C 4LMLA 5AINA 3U8MA 5KZUA 4TWFA 3UUBA 3TLSA 2YMDA 2W8FA 4LMKA 3T4MA 5HEJA 5J5HA 4XK9A 3JADA 4HFBA 3UQ7A 4B5DA 5BRXA 3LSVA 4Z91A 1UX2A 4WV9A 2YOEA 5L4HA 2YMEA 3UU8A 5AFJA 5AFKA 5J5IA 4BFQA 4HFDA 2Y7YA 4AFTA 2W8GA 3SQ9A 5HEGA 3C79A 3UU4A 4A97A 5J5FA 4AFGA 4HFHA 3EAMA 3U8LA 2BYNA 4BQTA 1UW6A 4IL9A 2PH9A 4F8HA 3WTMA 2BYQA 3ZKRA 3RQWA 5BP0A 3TLTA 2BR7A 4TWHA 2ZJUA 4AFHA 4A98A 5SYOA 2XZ6A 4HQPA 3WIPA 3WTJA 1I9BA 2BYRA 4QACA 3UU5A 2YKSA 3RQUA 3TLVA 2WNLA 3EHZA 2BG9A 3RIFA 3JAFA 3UQ4A 5FJVA 2Y54A 5LG3A 4ZRUA 5AFHA
chains in the Genus database with same CATH topology
4ZR6A 3TLUA 3GUAA 4HFEA 2XQ3A 2WNJA 3SIOA 2Y56A 3UU6A 4NPPA 4QABA 2BYPA 5L47A 2XQ5A 2UZ6A 2BJ0A 2X00D 2XQAA 3WTIA 3ZDGA 4ILBA 4ALXA 4COFA 2XYSA 3P4WA 5CO5A 5HEOA 3TLWA 5AFMB 2XQ6A 4ILAA 4TNVA 3WTKA 3SQ6A 4UXUA 4EZ1A 4ZZCA 3U8KA 3IGQA 4UY2A 3P50A 4DBMA 4UM3S 2WNCA 2XNUA 2BR8A 4X5TA 4QH4A 3U8NA 2BG9E 4QH1A 2XYTA 2XQ9A 2Y57A 4FRRA 5JMEA 2XNVA 4HFCA 4IREA 4HFIA 4ZK4A 5AFMA 3EI0A 2BYSA 2VL0A 4QAAA 3WTLA 5BW2A 3U8JA 3PMZA 4IL4A 3WTOA 4D01A 2C9TA 2WZYA 4ILCA 2XQ4A 3RHWA 2XZ5A 4UM1A 4ZJTA 5TVCA 3C84A 2QC1B 5AFNA 4TNWA 3RIAA 5HEUA 3WTHA 4XHEA 2XQ7A 5HCMA 5J0ZA 1UV6A 5AFLA 2ZJVA 4QH5A 3ZDHA 5LXBA 4UM3P 4Z90A 4TWDA 3WTNA 2Y58A 5IUXA 4LMJA 2YN6A 2XQ8A 3UU3A 5HEHA 4ZZBA 4ZK1A 2BG9B 3PEOA 3JAEA 5J5GA 2PGZA 4UM3A 4NZBA 2WN9A 5HCJA 4PIRA 4ZJSA 2X00A 2XNTA 3RI5A 3SH1A 5CFBA 5KE4A 5L4EA 2BG9C 4LMLA 5AINA 3U8MA 5KZUA 4TWFA 3UUBA 3TLSA 2YMDA 2W8FA 4LMKA 3T4MA 5HEJA 5J5HA 4XK9A 3JADA 4HFBA 3UQ7A 4B5DA 5BRXA 3LSVA 4Z91A 1UX2A 4WV9A 2YOEA 5L4HA 2YMEA 3UU8A 5AFJA 5AFKA 5J5IA 4BFQA 4HFDA 2Y7YA 4AFTA 2W8GA 3SQ9A 5HEGA 3C79A 3UU4A 4A97A 5J5FA 4AFGA 4HFHA 3EAMA 3U8LA 2BYNA 4BQTA 1UW6A 4IL9A 2PH9A 4F8HA 3WTMA 2BYQA 3ZKRA 3RQWA 5BP0A 3TLTA 2BR7A 4TWHA 2ZJUA 4AFHA 4A98A 5SYOA 2XZ6A 4HQPA 3WIPA 3WTJA 1I9BA 2BYRA 4QACA 3UU5A 2YKSA 3RQUA 3TLVA 2WNLA 3EHZA 2BG9A 3RIFA 3JAFA 3UQ4A 5FJVA 2Y54A 5LG3A 4ZRUA 5AFHA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4ZR6 A;  3TLU A;  3GUA A;  4HFE A;  2XQ3 A;  2WNJ A;  3SIO A;  2Y56 A;  3UU6 A;  4NPP A;  4QAB A;  2BYP A;  5L47 A;  2XQ5 A;  2UZ6 A;  2BJ0 A;  2X00 D;  2XQA A;  3WTI A;  3ZDG A;  4ILB A;  4ALX A;  4COF A;  2XYS A;  3P4W A;  5CO5 A;  5HEO A;  3TLW A;  5AFM B;  2XQ6 A;  4ILA A;  4TNV A;  3WTK A;  3SQ6 A;  4UXU A;  4EZ1 A;  4ZZC A;  3U8K A;  3IGQ A;  4UY2 A;  3P50 A;  4DBM A;  4UM3 S;  2WNC A;  2XNU A;  2BR8 A;  4X5T A;  4QH4 A;  3U8N A;  2BG9 E;  4QH1 A;  2XYT A;  2XQ9 A;  2Y57 A;  4FRR A;  5JME A;  2XNV A;  4HFC A;  4IRE A;  4HFI A;  4ZK4 A;  5AFM A;  3EI0 A;  2BYS A;  2VL0 A;  4QAA A;  3WTL A;  5BW2 A;  3U8J A;  3PMZ A;  4IL4 A;  3WTO A;  4D01 A;  2C9T A;  2WZY A;  4ILC A;  2XQ4 A;  3RHW A;  2XZ5 A;  4UM1 A;  4ZJT A;  5TVC A;  3C84 A;  2QC1 B;  5AFN A;  4TNW A;  3RIA A;  5HEU A;  3WTH A;  4XHE A;  2XQ7 A;  5HCM A;  5J0Z A;  1UV6 A;  5AFL A;  2ZJV A;  4QH5 A;  3ZDH A;  5LXB A;  4UM3 P;  4Z90 A;  4TWD A;  3WTN A;  2Y58 A;  5IUX A;  4LMJ A;  2YN6 A;  2XQ8 A;  3UU3 A;  5HEH A;  4ZZB A;  4ZK1 A;  2BG9 B;  3PEO A;  3JAE A;  5J5G A;  2PGZ A;  4UM3 A;  4NZB A;  2WN9 A;  5HCJ A;  4PIR A;  4ZJS A;  2X00 A;  2XNT A;  3RI5 A;  3SH1 A;  5CFB A;  5KE4 A;  5L4E A;  2BG9 C;  4LML A;  5AIN A;  3U8M A;  5KZU A;  4TWF A;  3UUB A;  3TLS A;  2YMD A;  2W8F A;  4LMK A;  3T4M A;  5HEJ A;  5J5H A;  4XK9 A;  3JAD A;  4HFB A;  3UQ7 A;  4B5D A;  5BRX A;  3LSV A;  4Z91 A;  1UX2 A;  4WV9 A;  2YOE A;  5L4H A;  2YME A;  3UU8 A;  5AFJ A;  5AFK A;  5J5I A;  4BFQ A;  4HFD A;  2Y7Y A;  4AFT A;  2W8G A;  3SQ9 A;  5HEG A;  3C79 A;  3UU4 A;  4A97 A;  5J5F A;  4AFG A;  4HFH A;  3EAM A;  3U8L A;  2BYN A;  4BQT A;  1UW6 A;  4IL9 A;  2PH9 A;  4F8H A;  3WTM A;  2BYQ A;  3ZKR A;  3RQW A;  5BP0 A;  3TLT A;  2BR7 A;  4TWH A;  2ZJU A;  4AFH A;  4A98 A;  5SYO A;  2XZ6 A;  4HQP A;  3WIP A;  3WTJ A;  1I9B A;  2BYR A;  4QAC A;  3UU5 A;  2YKS A;  3RQU A;  3TLV A;  2WNL A;  3EHZ A;  2BG9 A;  3RIF A;  3JAF A;  3UQ4 A;  5FJV A;  2Y54 A;  5LG3 A;  4ZRU A;  5AFH A; 
#chains in the Genus database with same CATH topology
 4ZR6 A;  3TLU A;  3GUA A;  4HFE A;  2XQ3 A;  2WNJ A;  3SIO A;  2Y56 A;  3UU6 A;  4NPP A;  4QAB A;  2BYP A;  5L47 A;  2XQ5 A;  2UZ6 A;  2BJ0 A;  2X00 D;  2XQA A;  3WTI A;  3ZDG A;  4ILB A;  4ALX A;  4COF A;  2XYS A;  3P4W A;  5CO5 A;  5HEO A;  3TLW A;  5AFM B;  2XQ6 A;  4ILA A;  4TNV A;  3WTK A;  3SQ6 A;  4UXU A;  4EZ1 A;  4ZZC A;  3U8K A;  3IGQ A;  4UY2 A;  3P50 A;  4DBM A;  4UM3 S;  2WNC A;  2XNU A;  2BR8 A;  4X5T A;  4QH4 A;  3U8N A;  2BG9 E;  4QH1 A;  2XYT A;  2XQ9 A;  2Y57 A;  4FRR A;  5JME A;  2XNV A;  4HFC A;  4IRE A;  4HFI A;  4ZK4 A;  5AFM A;  3EI0 A;  2BYS A;  2VL0 A;  4QAA A;  3WTL A;  5BW2 A;  3U8J A;  3PMZ A;  4IL4 A;  3WTO A;  4D01 A;  2C9T A;  2WZY A;  4ILC A;  2XQ4 A;  3RHW A;  2XZ5 A;  4UM1 A;  4ZJT A;  5TVC A;  3C84 A;  2QC1 B;  5AFN A;  4TNW A;  3RIA A;  5HEU A;  3WTH A;  4XHE A;  2XQ7 A;  5HCM A;  5J0Z A;  1UV6 A;  5AFL A;  2ZJV A;  4QH5 A;  3ZDH A;  5LXB A;  4UM3 P;  4Z90 A;  4TWD A;  3WTN A;  2Y58 A;  5IUX A;  4LMJ A;  2YN6 A;  2XQ8 A;  3UU3 A;  5HEH A;  4ZZB A;  4ZK1 A;  2BG9 B;  3PEO A;  3JAE A;  5J5G A;  2PGZ A;  4UM3 A;  4NZB A;  2WN9 A;  5HCJ A;  4PIR A;  4ZJS A;  2X00 A;  2XNT A;  3RI5 A;  3SH1 A;  5CFB A;  5KE4 A;  5L4E A;  2BG9 C;  4LML A;  5AIN A;  3U8M A;  5KZU A;  4TWF A;  3UUB A;  3TLS A;  2YMD A;  2W8F A;  4LMK A;  3T4M A;  5HEJ A;  5J5H A;  4XK9 A;  3JAD A;  4HFB A;  3UQ7 A;  4B5D A;  5BRX A;  3LSV A;  4Z91 A;  1UX2 A;  4WV9 A;  2YOE A;  5L4H A;  2YME A;  3UU8 A;  5AFJ A;  5AFK A;  5J5I A;  4BFQ A;  4HFD A;  2Y7Y A;  4AFT A;  2W8G A;  3SQ9 A;  5HEG A;  3C79 A;  3UU4 A;  4A97 A;  5J5F A;  4AFG A;  4HFH A;  3EAM A;  3U8L A;  2BYN A;  4BQT A;  1UW6 A;  4IL9 A;  2PH9 A;  4F8H A;  3WTM A;  2BYQ A;  3ZKR A;  3RQW A;  5BP0 A;  3TLT A;  2BR7 A;  4TWH A;  2ZJU A;  4AFH A;  4A98 A;  5SYO A;  2XZ6 A;  4HQP A;  3WIP A;  3WTJ A;  1I9B A;  2BYR A;  4QAC A;  3UU5 A;  2YKS A;  3RQU A;  3TLV A;  2WNL A;  3EHZ A;  2BG9 A;  3RIF A;  3JAF A;  3UQ4 A;  5FJV A;  2Y54 A;  5LG3 A;  4ZRU A;  5AFH A; 
#chains in the Genus database with same CATH homology
 4ZR6 A;  3TLU A;  3GUA A;  4HFE A;  2XQ3 A;  2WNJ A;  3SIO A;  2Y56 A;  3UU6 A;  4NPP A;  4QAB A;  2BYP A;  5L47 A;  2XQ5 A;  2UZ6 A;  2BJ0 A;  2X00 D;  2XQA A;  3WTI A;  3ZDG A;  4ILB A;  4ALX A;  4COF A;  2XYS A;  3P4W A;  5CO5 A;  5HEO A;  3TLW A;  5AFM B;  2XQ6 A;  4ILA A;  4TNV A;  3WTK A;  3SQ6 A;  4UXU A;  4EZ1 A;  4ZZC A;  3U8K A;  3IGQ A;  4UY2 A;  3P50 A;  4DBM A;  4UM3 S;  2WNC A;  2XNU A;  2BR8 A;  4X5T A;  4QH4 A;  3U8N A;  2BG9 E;  4QH1 A;  2XYT A;  2XQ9 A;  2Y57 A;  4FRR A;  5JME A;  2XNV A;  4HFC A;  4IRE A;  4HFI A;  4ZK4 A;  5AFM A;  3EI0 A;  2BYS A;  2VL0 A;  4QAA A;  3WTL A;  5BW2 A;  3U8J A;  3PMZ A;  4IL4 A;  3WTO A;  4D01 A;  2C9T A;  2WZY A;  4ILC A;  2XQ4 A;  3RHW A;  2XZ5 A;  4UM1 A;  4ZJT A;  5TVC A;  3C84 A;  2QC1 B;  5AFN A;  4TNW A;  3RIA A;  5HEU A;  3WTH A;  4XHE A;  2XQ7 A;  5HCM A;  5J0Z A;  1UV6 A;  5AFL A;  2ZJV A;  4QH5 A;  3ZDH A;  5LXB A;  4UM3 P;  4Z90 A;  4TWD A;  3WTN A;  2Y58 A;  5IUX A;  4LMJ A;  2YN6 A;  2XQ8 A;  3UU3 A;  5HEH A;  4ZZB A;  4ZK1 A;  2BG9 B;  3PEO A;  3JAE A;  5J5G A;  2PGZ A;  4UM3 A;  4NZB A;  2WN9 A;  5HCJ A;  4PIR A;  4ZJS A;  2X00 A;  2XNT A;  3RI5 A;  3SH1 A;  5CFB A;  5KE4 A;  5L4E A;  2BG9 C;  4LML A;  5AIN A;  3U8M A;  5KZU A;  4TWF A;  3UUB A;  3TLS A;  2YMD A;  2W8F A;  4LMK A;  3T4M A;  5HEJ A;  5J5H A;  4XK9 A;  3JAD A;  4HFB A;  3UQ7 A;  4B5D A;  5BRX A;  3LSV A;  4Z91 A;  1UX2 A;  4WV9 A;  2YOE A;  5L4H A;  2YME A;  3UU8 A;  5AFJ A;  5AFK A;  5J5I A;  4BFQ A;  4HFD A;  2Y7Y A;  4AFT A;  2W8G A;  3SQ9 A;  5HEG A;  3C79 A;  3UU4 A;  4A97 A;  5J5F A;  4AFG A;  4HFH A;  3EAM A;  3U8L A;  2BYN A;  4BQT A;  1UW6 A;  4IL9 A;  2PH9 A;  4F8H A;  3WTM A;  2BYQ A;  3ZKR A;  3RQW A;  5BP0 A;  3TLT A;  2BR7 A;  4TWH A;  2ZJU A;  4AFH A;  4A98 A;  5SYO A;  2XZ6 A;  4HQP A;  3WIP A;  3WTJ A;  1I9B A;  2BYR A;  4QAC A;  3UU5 A;  2YKS A;  3RQU A;  3TLV A;  2WNL A;  3EHZ A;  2BG9 A;  3RIF A;  3JAF A;  3UQ4 A;  5FJV A;  2Y54 A;  5LG3 A;  4ZRU A;  5AFH A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...