5TVCA

Crystal structure of a chimeric acetylcholine binding protein from aplysia californica (ac-achbp) containing loop c from the human alpha 3 nicotinic acetylcholine receptor in complex with (e,2s)-n-methyl-5-(5-phenoxy-3-pyridyl)pent-4-en-2-amine (ti-5312)
Total Genus 47
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
47
sequence length
216
structure length
211
Chain Sequence
DKLHSQANLMRLKSDLFYPGPTKDDPLTVTLGFTLQDIVKADSSTNEVDLVYWEQQRWKLNSLMWDPNEYGNITDFRTSAADIWTPDITAYSSTRPVQVLSPQIAVVTHDGSVMFIPAQRLSFMCDPTGVDSEEGATCAVKFGSWVYSGFEIDLKTDTDQVDLSSYYASSKYEILSATQYKHDIKYNCCEEIYPDVVLVVKFRERRAGNGF
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Acetylcholine-binding protein
source organism Aplysia californica
publication title Crystal structure of a chimeric acetylcholine binding protein from Aplysia californica (Ac-AChBP) containing loop C from the human alpha 3 nicotinic acetylcholine receptor in complex with (E,2S)-N-methyl-5-(5-phenoxy-3-pyridyl)pent-4-en-2-amine (TI-5312)
rcsb
molecule keywords Soluble acetylcholine receptor,Neuronal acetylcholine recept
total genus 47
structure length 211
sequence length 216
chains with identical sequence B, C, D, E
ec nomenclature
pdb deposition date 2016-11-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02931 Neur_chan_LBD Neurotransmitter-gated ion-channel ligand binding domain
A PF02931 Neur_chan_LBD Neurotransmitter-gated ion-channel ligand binding domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.170.10 Mainly Beta Distorted Sandwich Acetylcholine Binding Protein; Chain: A, Neurotransmitter-gated ion-channel ligand-binding domain 5tvcA00
3SH1A 4COFA 2YMDA 4QACA 4HFEA 4ILAA 4TNWA 4B5DA 5BP0A 5HEOA 2VL0A 1UX2A 2ZJVA 2WN9A 4UM3A 4IL4A 2XQAA 2BYRA 2Y58A 2XYSA 4ZZBA 3RIAA 2BJ0A 2Y56A 3LSVA 2YOEA 2Y7YA 5CO5A 5HEUA 3U8JA 4UM3S 5AINA 4UM1A 2YN6A 3U8NA 1UW6A 3TLWA 2WZYA 3TLUA 4ALXA 4HFHA 4A98A 2BYNA 3JAEA 4BQTA 3JADA 3RI5A 2XNUA 5CFBA 4WV9A 4X5TA 4Z90A 4FRRA 4HFIA 5HEHA 5AFHA 4D01A 3WIPA 5J5GA 2XQ5A 3WTOA 5JMEA 5AFLA 2BR7A 3UU3A 3EHZA 2BG9A 2XQ4A 5AFKA 4NPPA 2YMEA 3U8KA 3TLSA 3WTJA 3WTIA 4TWHA 3UUBA 5LXBA 3SQ6A 5HCJA 4AFGA 2XNTA 4Z91A 4ZK4A 3ZDGA 3EAMA 4HFBA 2W8GA 4ZR6A 4F8HA 5AFNA 3WTHA 3RIFA 5FJVA 3WTKA 5IUXA 5AFMA 5J5IA 4ILCA 4AFHA 4ILBA 3ZDHA 2Y57A 3C79A 3TLVA 2XQ8A 5TVCA 2BG9B 3UQ4A 2BR8A 1I9BA 4AFTA 2XQ6A 3IGQA 3RHWA 4HQPA 2WNJA 4A97A 4QAAA 5HEJA 3EI0A 2ZJUA 3P50A 3U8MA 2BYSA 4PIRA 4TWDA 3PMZA 3C84A 3SIOA 3PEOA 4LMKA 4ZJTA 4UY2A 4EZ1A 5BRXA 5LG3A 4LMJA 3UU4A 5BW2A 5AFMB 4TNVA 5SYOA 5J5HA 3RQWA 2XNVA 2X00D 2XZ5A 2XQ9A 3JAFA 3GUAA 5L4HA 4BFQA 3RQUA 4QH4A 5J5FA 2PH9A 2WNLA 4HFCA 4XHEA 4UXUA 2XQ3A 2UZ6A 4ZRUA 3WTMA 2BYPA 5AFJA 4HFDA 5HEGA 4ZJSA 2YKSA 4ZZCA 3TLTA 4UM3P 5L47A 3ZKRA 4LMLA 3WTNA 4XK9A 3UU6A 1UV6A 4ZK1A 2XQ7A 2BG9C 2PGZA 5KE4A 2QC1B 2XZ6A 4QABA 5J0ZA 3UU5A 2C9TA 2X00A 4QH5A 4IREA 5L4EA 2XYTA 4NZBA 4TWFA 5KZUA 3U8LA 5HCMA 3WTLA 3SQ9A 4QH1A 2BYQA 3UU8A 2BG9E 4DBMA 2WNCA 2Y54A 3T4MA 3UQ7A 3P4WA 4IL9A 2W8FA
chains in the Genus database with same CATH superfamily
3SH1A 4COFA 2YMDA 4QACA 4HFEA 4ILAA 4TNWA 4B5DA 5BP0A 5HEOA 2VL0A 1UX2A 2ZJVA 2WN9A 4UM3A 4IL4A 2XQAA 2BYRA 2Y58A 2XYSA 4ZZBA 3RIAA 2BJ0A 2Y56A 3LSVA 2YOEA 2Y7YA 5CO5A 5HEUA 3U8JA 4UM3S 5AINA 4UM1A 2YN6A 3U8NA 1UW6A 3TLWA 2WZYA 3TLUA 4ALXA 4HFHA 4A98A 2BYNA 3JAEA 4BQTA 3JADA 3RI5A 2XNUA 5CFBA 4WV9A 4X5TA 4Z90A 4FRRA 4HFIA 5HEHA 5AFHA 4D01A 3WIPA 5J5GA 2XQ5A 3WTOA 5JMEA 5AFLA 2BR7A 3UU3A 3EHZA 2BG9A 2XQ4A 5AFKA 4NPPA 2YMEA 3U8KA 3TLSA 3WTJA 3WTIA 4TWHA 3UUBA 5LXBA 3SQ6A 5HCJA 4AFGA 2XNTA 4Z91A 4ZK4A 3ZDGA 3EAMA 4HFBA 2W8GA 4ZR6A 4F8HA 5AFNA 3WTHA 3RIFA 5FJVA 3WTKA 5IUXA 5AFMA 5J5IA 4ILCA 4AFHA 4ILBA 3ZDHA 2Y57A 3C79A 3TLVA 2XQ8A 5TVCA 2BG9B 3UQ4A 2BR8A 1I9BA 4AFTA 2XQ6A 3IGQA 3RHWA 4HQPA 2WNJA 4A97A 4QAAA 5HEJA 3EI0A 2ZJUA 3P50A 3U8MA 2BYSA 4PIRA 4TWDA 3PMZA 3C84A 3SIOA 3PEOA 4LMKA 4ZJTA 4UY2A 4EZ1A 5BRXA 5LG3A 4LMJA 3UU4A 5BW2A 5AFMB 4TNVA 5SYOA 5J5HA 3RQWA 2XNVA 2X00D 2XZ5A 2XQ9A 3JAFA 3GUAA 5L4HA 4BFQA 3RQUA 4QH4A 5J5FA 2PH9A 2WNLA 4HFCA 4XHEA 4UXUA 2XQ3A 2UZ6A 4ZRUA 3WTMA 2BYPA 5AFJA 4HFDA 5HEGA 4ZJSA 2YKSA 4ZZCA 3TLTA 4UM3P 5L47A 3ZKRA 4LMLA 3WTNA 4XK9A 3UU6A 1UV6A 4ZK1A 2XQ7A 2BG9C 2PGZA 5KE4A 2QC1B 2XZ6A 4QABA 5J0ZA 3UU5A 2C9TA 2X00A 4QH5A 4IREA 5L4EA 2XYTA 4NZBA 4TWFA 5KZUA 3U8LA 5HCMA 3WTLA 3SQ9A 4QH1A 2BYQA 3UU8A 2BG9E 4DBMA 2WNCA 2Y54A 3T4MA 3UQ7A 3P4WA 4IL9A 2W8FA
chains in the Genus database with same CATH topology
3SH1A 4COFA 2YMDA 4QACA 4HFEA 4ILAA 4TNWA 4B5DA 5BP0A 5HEOA 2VL0A 1UX2A 2ZJVA 2WN9A 4UM3A 4IL4A 2XQAA 2BYRA 2Y58A 2XYSA 4ZZBA 3RIAA 2BJ0A 2Y56A 3LSVA 2YOEA 2Y7YA 5CO5A 5HEUA 3U8JA 4UM3S 5AINA 4UM1A 2YN6A 3U8NA 1UW6A 3TLWA 2WZYA 3TLUA 4ALXA 4HFHA 4A98A 2BYNA 3JAEA 4BQTA 3JADA 3RI5A 2XNUA 5CFBA 4WV9A 4X5TA 4Z90A 4FRRA 4HFIA 5HEHA 5AFHA 4D01A 3WIPA 5J5GA 2XQ5A 3WTOA 5JMEA 5AFLA 2BR7A 3UU3A 3EHZA 2BG9A 2XQ4A 5AFKA 4NPPA 2YMEA 3U8KA 3TLSA 3WTJA 3WTIA 4TWHA 3UUBA 5LXBA 3SQ6A 5HCJA 4AFGA 2XNTA 4Z91A 4ZK4A 3ZDGA 3EAMA 4HFBA 2W8GA 4ZR6A 4F8HA 5AFNA 3WTHA 3RIFA 5FJVA 3WTKA 5IUXA 5AFMA 5J5IA 4ILCA 4AFHA 4ILBA 3ZDHA 2Y57A 3C79A 3TLVA 2XQ8A 5TVCA 2BG9B 3UQ4A 2BR8A 1I9BA 4AFTA 2XQ6A 3IGQA 3RHWA 4HQPA 2WNJA 4A97A 4QAAA 5HEJA 3EI0A 2ZJUA 3P50A 3U8MA 2BYSA 4PIRA 4TWDA 3PMZA 3C84A 3SIOA 3PEOA 4LMKA 4ZJTA 4UY2A 4EZ1A 5BRXA 5LG3A 4LMJA 3UU4A 5BW2A 5AFMB 4TNVA 5SYOA 5J5HA 3RQWA 2XNVA 2X00D 2XZ5A 2XQ9A 3JAFA 3GUAA 5L4HA 4BFQA 3RQUA 4QH4A 5J5FA 2PH9A 2WNLA 4HFCA 4XHEA 4UXUA 2XQ3A 2UZ6A 4ZRUA 3WTMA 2BYPA 5AFJA 4HFDA 5HEGA 4ZJSA 2YKSA 4ZZCA 3TLTA 4UM3P 5L47A 3ZKRA 4LMLA 3WTNA 4XK9A 3UU6A 1UV6A 4ZK1A 2XQ7A 2BG9C 2PGZA 5KE4A 2QC1B 2XZ6A 4QABA 5J0ZA 3UU5A 2C9TA 2X00A 4QH5A 4IREA 5L4EA 2XYTA 4NZBA 4TWFA 5KZUA 3U8LA 5HCMA 3WTLA 3SQ9A 4QH1A 2BYQA 3UU8A 2BG9E 4DBMA 2WNCA 2Y54A 3T4MA 3UQ7A 3P4WA 4IL9A 2W8FA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3SH1 A;  4COF A;  2YMD A;  4QAC A;  4HFE A;  4ILA A;  4TNW A;  4B5D A;  5BP0 A;  5HEO A;  2VL0 A;  1UX2 A;  2ZJV A;  2WN9 A;  4UM3 A;  4IL4 A;  2XQA A;  2BYR A;  2Y58 A;  2XYS A;  4ZZB A;  3RIA A;  2BJ0 A;  2Y56 A;  3LSV A;  2YOE A;  2Y7Y A;  5CO5 A;  5HEU A;  3U8J A;  4UM3 S;  5AIN A;  4UM1 A;  2YN6 A;  3U8N A;  1UW6 A;  3TLW A;  2WZY A;  3TLU A;  4ALX A;  4HFH A;  4A98 A;  2BYN A;  3JAE A;  4BQT A;  3JAD A;  3RI5 A;  2XNU A;  5CFB A;  4WV9 A;  4X5T A;  4Z90 A;  4FRR A;  4HFI A;  5HEH A;  5AFH A;  4D01 A;  3WIP A;  5J5G A;  2XQ5 A;  3WTO A;  5JME A;  5AFL A;  2BR7 A;  3UU3 A;  3EHZ A;  2BG9 A;  2XQ4 A;  5AFK A;  4NPP A;  2YME A;  3U8K A;  3TLS A;  3WTJ A;  3WTI A;  4TWH A;  3UUB A;  5LXB A;  3SQ6 A;  5HCJ A;  4AFG A;  2XNT A;  4Z91 A;  4ZK4 A;  3ZDG A;  3EAM A;  4HFB A;  2W8G A;  4ZR6 A;  4F8H A;  5AFN A;  3WTH A;  3RIF A;  5FJV A;  3WTK A;  5IUX A;  5AFM A;  5J5I A;  4ILC A;  4AFH A;  4ILB A;  3ZDH A;  2Y57 A;  3C79 A;  3TLV A;  2XQ8 A;  5TVC A;  2BG9 B;  3UQ4 A;  2BR8 A;  1I9B A;  4AFT A;  2XQ6 A;  3IGQ A;  3RHW A;  4HQP A;  2WNJ A;  4A97 A;  4QAA A;  5HEJ A;  3EI0 A;  2ZJU A;  3P50 A;  3U8M A;  2BYS A;  4PIR A;  4TWD A;  3PMZ A;  3C84 A;  3SIO A;  3PEO A;  4LMK A;  4ZJT A;  4UY2 A;  4EZ1 A;  5BRX A;  5LG3 A;  4LMJ A;  3UU4 A;  5BW2 A;  5AFM B;  4TNV A;  5SYO A;  5J5H A;  3RQW A;  2XNV A;  2X00 D;  2XZ5 A;  2XQ9 A;  3JAF A;  3GUA A;  5L4H A;  4BFQ A;  3RQU A;  4QH4 A;  5J5F A;  2PH9 A;  2WNL A;  4HFC A;  4XHE A;  4UXU A;  2XQ3 A;  2UZ6 A;  4ZRU A;  3WTM A;  2BYP A;  5AFJ A;  4HFD A;  5HEG A;  4ZJS A;  2YKS A;  4ZZC A;  3TLT A;  4UM3 P;  5L47 A;  3ZKR A;  4LML A;  3WTN A;  4XK9 A;  3UU6 A;  1UV6 A;  4ZK1 A;  2XQ7 A;  2BG9 C;  2PGZ A;  5KE4 A;  2QC1 B;  2XZ6 A;  4QAB A;  5J0Z A;  3UU5 A;  2C9T A;  2X00 A;  4QH5 A;  4IRE A;  5L4E A;  2XYT A;  4NZB A;  4TWF A;  5KZU A;  3U8L A;  5HCM A;  3WTL A;  3SQ9 A;  4QH1 A;  2BYQ A;  3UU8 A;  2BG9 E;  4DBM A;  2WNC A;  2Y54 A;  3T4M A;  3UQ7 A;  3P4W A;  4IL9 A;  2W8F A; 
#chains in the Genus database with same CATH topology
 3SH1 A;  4COF A;  2YMD A;  4QAC A;  4HFE A;  4ILA A;  4TNW A;  4B5D A;  5BP0 A;  5HEO A;  2VL0 A;  1UX2 A;  2ZJV A;  2WN9 A;  4UM3 A;  4IL4 A;  2XQA A;  2BYR A;  2Y58 A;  2XYS A;  4ZZB A;  3RIA A;  2BJ0 A;  2Y56 A;  3LSV A;  2YOE A;  2Y7Y A;  5CO5 A;  5HEU A;  3U8J A;  4UM3 S;  5AIN A;  4UM1 A;  2YN6 A;  3U8N A;  1UW6 A;  3TLW A;  2WZY A;  3TLU A;  4ALX A;  4HFH A;  4A98 A;  2BYN A;  3JAE A;  4BQT A;  3JAD A;  3RI5 A;  2XNU A;  5CFB A;  4WV9 A;  4X5T A;  4Z90 A;  4FRR A;  4HFI A;  5HEH A;  5AFH A;  4D01 A;  3WIP A;  5J5G A;  2XQ5 A;  3WTO A;  5JME A;  5AFL A;  2BR7 A;  3UU3 A;  3EHZ A;  2BG9 A;  2XQ4 A;  5AFK A;  4NPP A;  2YME A;  3U8K A;  3TLS A;  3WTJ A;  3WTI A;  4TWH A;  3UUB A;  5LXB A;  3SQ6 A;  5HCJ A;  4AFG A;  2XNT A;  4Z91 A;  4ZK4 A;  3ZDG A;  3EAM A;  4HFB A;  2W8G A;  4ZR6 A;  4F8H A;  5AFN A;  3WTH A;  3RIF A;  5FJV A;  3WTK A;  5IUX A;  5AFM A;  5J5I A;  4ILC A;  4AFH A;  4ILB A;  3ZDH A;  2Y57 A;  3C79 A;  3TLV A;  2XQ8 A;  5TVC A;  2BG9 B;  3UQ4 A;  2BR8 A;  1I9B A;  4AFT A;  2XQ6 A;  3IGQ A;  3RHW A;  4HQP A;  2WNJ A;  4A97 A;  4QAA A;  5HEJ A;  3EI0 A;  2ZJU A;  3P50 A;  3U8M A;  2BYS A;  4PIR A;  4TWD A;  3PMZ A;  3C84 A;  3SIO A;  3PEO A;  4LMK A;  4ZJT A;  4UY2 A;  4EZ1 A;  5BRX A;  5LG3 A;  4LMJ A;  3UU4 A;  5BW2 A;  5AFM B;  4TNV A;  5SYO A;  5J5H A;  3RQW A;  2XNV A;  2X00 D;  2XZ5 A;  2XQ9 A;  3JAF A;  3GUA A;  5L4H A;  4BFQ A;  3RQU A;  4QH4 A;  5J5F A;  2PH9 A;  2WNL A;  4HFC A;  4XHE A;  4UXU A;  2XQ3 A;  2UZ6 A;  4ZRU A;  3WTM A;  2BYP A;  5AFJ A;  4HFD A;  5HEG A;  4ZJS A;  2YKS A;  4ZZC A;  3TLT A;  4UM3 P;  5L47 A;  3ZKR A;  4LML A;  3WTN A;  4XK9 A;  3UU6 A;  1UV6 A;  4ZK1 A;  2XQ7 A;  2BG9 C;  2PGZ A;  5KE4 A;  2QC1 B;  2XZ6 A;  4QAB A;  5J0Z A;  3UU5 A;  2C9T A;  2X00 A;  4QH5 A;  4IRE A;  5L4E A;  2XYT A;  4NZB A;  4TWF A;  5KZU A;  3U8L A;  5HCM A;  3WTL A;  3SQ9 A;  4QH1 A;  2BYQ A;  3UU8 A;  2BG9 E;  4DBM A;  2WNC A;  2Y54 A;  3T4M A;  3UQ7 A;  3P4W A;  4IL9 A;  2W8F A; 
#chains in the Genus database with same CATH homology
 3SH1 A;  4COF A;  2YMD A;  4QAC A;  4HFE A;  4ILA A;  4TNW A;  4B5D A;  5BP0 A;  5HEO A;  2VL0 A;  1UX2 A;  2ZJV A;  2WN9 A;  4UM3 A;  4IL4 A;  2XQA A;  2BYR A;  2Y58 A;  2XYS A;  4ZZB A;  3RIA A;  2BJ0 A;  2Y56 A;  3LSV A;  2YOE A;  2Y7Y A;  5CO5 A;  5HEU A;  3U8J A;  4UM3 S;  5AIN A;  4UM1 A;  2YN6 A;  3U8N A;  1UW6 A;  3TLW A;  2WZY A;  3TLU A;  4ALX A;  4HFH A;  4A98 A;  2BYN A;  3JAE A;  4BQT A;  3JAD A;  3RI5 A;  2XNU A;  5CFB A;  4WV9 A;  4X5T A;  4Z90 A;  4FRR A;  4HFI A;  5HEH A;  5AFH A;  4D01 A;  3WIP A;  5J5G A;  2XQ5 A;  3WTO A;  5JME A;  5AFL A;  2BR7 A;  3UU3 A;  3EHZ A;  2BG9 A;  2XQ4 A;  5AFK A;  4NPP A;  2YME A;  3U8K A;  3TLS A;  3WTJ A;  3WTI A;  4TWH A;  3UUB A;  5LXB A;  3SQ6 A;  5HCJ A;  4AFG A;  2XNT A;  4Z91 A;  4ZK4 A;  3ZDG A;  3EAM A;  4HFB A;  2W8G A;  4ZR6 A;  4F8H A;  5AFN A;  3WTH A;  3RIF A;  5FJV A;  3WTK A;  5IUX A;  5AFM A;  5J5I A;  4ILC A;  4AFH A;  4ILB A;  3ZDH A;  2Y57 A;  3C79 A;  3TLV A;  2XQ8 A;  5TVC A;  2BG9 B;  3UQ4 A;  2BR8 A;  1I9B A;  4AFT A;  2XQ6 A;  3IGQ A;  3RHW A;  4HQP A;  2WNJ A;  4A97 A;  4QAA A;  5HEJ A;  3EI0 A;  2ZJU A;  3P50 A;  3U8M A;  2BYS A;  4PIR A;  4TWD A;  3PMZ A;  3C84 A;  3SIO A;  3PEO A;  4LMK A;  4ZJT A;  4UY2 A;  4EZ1 A;  5BRX A;  5LG3 A;  4LMJ A;  3UU4 A;  5BW2 A;  5AFM B;  4TNV A;  5SYO A;  5J5H A;  3RQW A;  2XNV A;  2X00 D;  2XZ5 A;  2XQ9 A;  3JAF A;  3GUA A;  5L4H A;  4BFQ A;  3RQU A;  4QH4 A;  5J5F A;  2PH9 A;  2WNL A;  4HFC A;  4XHE A;  4UXU A;  2XQ3 A;  2UZ6 A;  4ZRU A;  3WTM A;  2BYP A;  5AFJ A;  4HFD A;  5HEG A;  4ZJS A;  2YKS A;  4ZZC A;  3TLT A;  4UM3 P;  5L47 A;  3ZKR A;  4LML A;  3WTN A;  4XK9 A;  3UU6 A;  1UV6 A;  4ZK1 A;  2XQ7 A;  2BG9 C;  2PGZ A;  5KE4 A;  2QC1 B;  2XZ6 A;  4QAB A;  5J0Z A;  3UU5 A;  2C9T A;  2X00 A;  4QH5 A;  4IRE A;  5L4E A;  2XYT A;  4NZB A;  4TWF A;  5KZU A;  3U8L A;  5HCM A;  3WTL A;  3SQ9 A;  4QH1 A;  2BYQ A;  3UU8 A;  2BG9 E;  4DBM A;  2WNC A;  2Y54 A;  3T4M A;  3UQ7 A;  3P4W A;  4IL9 A;  2W8F A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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