5TVCA

Crystal structure of a chimeric acetylcholine binding protein from aplysia californica (ac-achbp) containing loop c from the human alpha 3 nicotinic acetylcholine receptor in complex with (e,2s)-n-methyl-5-(5-phenoxy-3-pyridyl)pent-4-en-2-amine (ti-5312)
Total Genus 47
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
47
sequence length
216
structure length
211
Chain Sequence
DKLHSQANLMRLKSDLFYPGPTKDDPLTVTLGFTLQDIVKADSSTNEVDLVYWEQQRWKLNSLMWDPNEYGNITDFRTSAADIWTPDITAYSSTRPVQVLSPQIAVVTHDGSVMFIPAQRLSFMCDPTGVDSEEGATCAVKFGSWVYSGFEIDLKTDTDQVDLSSYYASSKYEILSATQYKHDIKYNCCEEIYPDVVLVVKFRERRAGNGF
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Acetylcholine-binding protein
molecule keywords Soluble acetylcholine receptor,Neuronal acetylcholine recept
publication title Crystal structure of a chimeric acetylcholine binding protein from Aplysia californica (Ac-AChBP) containing loop C from the human alpha 3 nicotinic acetylcholine receptor in complex with (E,2S)-N-methyl-5-(5-phenoxy-3-pyridyl)pent-4-en-2-amine (TI-5312)
rcsb
source organism Aplysia californica
total genus 47
structure length 211
sequence length 216
chains with identical sequence B, C, D, E
ec nomenclature
pdb deposition date 2016-11-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02931 Neur_chan_LBD Neurotransmitter-gated ion-channel ligand binding domain
A PF02931 Neur_chan_LBD Neurotransmitter-gated ion-channel ligand binding domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.170.10 Mainly Beta Distorted Sandwich Acetylcholine Binding Protein; Chain: A, Neurotransmitter-gated ion-channel ligand-binding domain 5tvcA00
3UUBA 2XNUA 5CFBA 5JMEA 4AFTA 2X00A 5TVCA 2PH9A 3TLVA 4QH4A 3U8MA 3WIPA 2BYQA 2WN9A 3C79A 2C9TA 3WTIA 3JADA 4XK9A 2XYSA 4TNWA 2WNLA 4ZZBA 4NPPA 3EAMA 4BQTA 4UM3A 3WTLA 3WTOA 3U8LA 3WTKA 2WNJA 4D01A 4AFHA 4FRRA 2WNCA 5KE4A 5HEGA 5KZUA 3UU5A 2XQ9A 3RIFA 4ALXA 3WTJA 1UV6A 3WTHA 3TLUA 2YKSA 4TWFA 4UY2A 4COFA 2XQAA 4BFQA 3C84A 2BG9B 2XQ7A 3JAFA 5L4EA 3EHZA 2XQ5A 4X5TA 2BYPA 4ZRUA 4ZZCA 3JAEA 3UQ7A 2BR7A 4PIRA 5LXBA 5AFNA 3RHWA 4QH5A 4UM3P 1UW6A 4TWHA 3T4MA 5HCMA 3RQUA 5BW2A 4HFIA 3P50A 4UXUA 3U8KA 3PEOA 3RI5A 3LSVA 2XZ5A 2PGZA 4TNVA 5AFMB 2XYTA 4ZK1A 2YOEA 4ZR6A 3UQ4A 2XQ8A 4F8HA 5AFLA 5AINA 3UU8A 4B5DA 4IL9A 4DBMA 3TLTA 4ZJSA 3TLWA 2YN6A 3UU4A 5HEJA 3P4WA 4HFEA 3ZKRA 5AFHA 4ILAA 2BYNA 4UM1A 3SQ9A 2BYRA 2YMDA 2WZYA 2XZ6A 2QC1B 4HFBA 3EI0A 4AFGA 5HEHA 3IGQA 4HFCA 4ZK4A 3WTNA 4IREA 4QABA 3ZDGA 4HQPA 3WTMA 2UZ6A 3RIAA 3ZDHA 5BP0A 4A97A 5FJVA 5CO5A 5IUXA 2YMEA 5SYOA 2Y57A 5HEUA 3U8NA 2BG9A 5LG3A 5J5IA 2Y56A 3GUAA 3UU3A 2X00D 4TWDA 2BJ0A 5L47A 2BYSA 2Y54A 4LMLA 3TLSA 2XQ4A 4QH1A 4WV9A 2XNTA 4ILBA 5J5GA 4ZJTA 2XQ6A 4HFHA 4A98A 5AFJA 4UM3S 4Z90A 2ZJVA 2ZJUA 4XHEA 5AFMA 2XNVA 5HEOA 4IL4A 2VL0A 4HFDA 5HCJA 3SH1A 2BG9C 2BR8A 2Y58A 2W8GA 2Y7YA 4QACA 4LMKA 5L4HA 5BRXA 3RQWA 2XQ3A 3U8JA 5J5FA 3SQ6A 4EZ1A 5AFKA 4ILCA 4NZBA 4LMJA 4QAAA 5J0ZA 5J5HA 1I9BA 3UU6A 3SIOA 2W8FA 1UX2A 3PMZA 2BG9E 4Z91A
chains in the Genus database with same CATH superfamily
3UUBA 2XNUA 5CFBA 5JMEA 4AFTA 2X00A 5TVCA 2PH9A 3TLVA 4QH4A 3U8MA 3WIPA 2BYQA 2WN9A 3C79A 2C9TA 3WTIA 3JADA 4XK9A 2XYSA 4TNWA 2WNLA 4ZZBA 4NPPA 3EAMA 4BQTA 4UM3A 3WTLA 3WTOA 3U8LA 3WTKA 2WNJA 4D01A 4AFHA 4FRRA 2WNCA 5KE4A 5HEGA 5KZUA 3UU5A 2XQ9A 3RIFA 4ALXA 3WTJA 1UV6A 3WTHA 3TLUA 2YKSA 4TWFA 4UY2A 4COFA 2XQAA 4BFQA 3C84A 2BG9B 2XQ7A 3JAFA 5L4EA 3EHZA 2XQ5A 4X5TA 2BYPA 4ZRUA 4ZZCA 3JAEA 3UQ7A 2BR7A 4PIRA 5LXBA 5AFNA 3RHWA 4QH5A 4UM3P 1UW6A 4TWHA 3T4MA 5HCMA 3RQUA 5BW2A 4HFIA 3P50A 4UXUA 3U8KA 3PEOA 3RI5A 3LSVA 2XZ5A 2PGZA 4TNVA 5AFMB 2XYTA 4ZK1A 2YOEA 4ZR6A 3UQ4A 2XQ8A 4F8HA 5AFLA 5AINA 3UU8A 4B5DA 4IL9A 4DBMA 3TLTA 4ZJSA 3TLWA 2YN6A 3UU4A 5HEJA 3P4WA 4HFEA 3ZKRA 5AFHA 4ILAA 2BYNA 4UM1A 3SQ9A 2BYRA 2YMDA 2WZYA 2XZ6A 2QC1B 4HFBA 3EI0A 4AFGA 5HEHA 3IGQA 4HFCA 4ZK4A 3WTNA 4IREA 4QABA 3ZDGA 4HQPA 3WTMA 2UZ6A 3RIAA 3ZDHA 5BP0A 4A97A 5FJVA 5CO5A 5IUXA 2YMEA 5SYOA 2Y57A 5HEUA 3U8NA 2BG9A 5LG3A 5J5IA 2Y56A 3GUAA 3UU3A 2X00D 4TWDA 2BJ0A 5L47A 2BYSA 2Y54A 4LMLA 3TLSA 2XQ4A 4QH1A 4WV9A 2XNTA 4ILBA 5J5GA 4ZJTA 2XQ6A 4HFHA 4A98A 5AFJA 4UM3S 4Z90A 2ZJVA 2ZJUA 4XHEA 5AFMA 2XNVA 5HEOA 4IL4A 2VL0A 4HFDA 5HCJA 3SH1A 2BG9C 2BR8A 2Y58A 2W8GA 2Y7YA 4QACA 4LMKA 5L4HA 5BRXA 3RQWA 2XQ3A 3U8JA 5J5FA 3SQ6A 4EZ1A 5AFKA 4ILCA 4NZBA 4LMJA 4QAAA 5J0ZA 5J5HA 1I9BA 3UU6A 3SIOA 2W8FA 1UX2A 3PMZA 2BG9E 4Z91A
chains in the Genus database with same CATH topology
3UUBA 2XNUA 5CFBA 5JMEA 4AFTA 2X00A 5TVCA 2PH9A 3TLVA 4QH4A 3U8MA 3WIPA 2BYQA 2WN9A 3C79A 2C9TA 3WTIA 3JADA 4XK9A 2XYSA 4TNWA 2WNLA 4ZZBA 4NPPA 3EAMA 4BQTA 4UM3A 3WTLA 3WTOA 3U8LA 3WTKA 2WNJA 4D01A 4AFHA 4FRRA 2WNCA 5KE4A 5HEGA 5KZUA 3UU5A 2XQ9A 3RIFA 4ALXA 3WTJA 1UV6A 3WTHA 3TLUA 2YKSA 4TWFA 4UY2A 4COFA 2XQAA 4BFQA 3C84A 2BG9B 2XQ7A 3JAFA 5L4EA 3EHZA 2XQ5A 4X5TA 2BYPA 4ZRUA 4ZZCA 3JAEA 3UQ7A 2BR7A 4PIRA 5LXBA 5AFNA 3RHWA 4QH5A 4UM3P 1UW6A 4TWHA 3T4MA 5HCMA 3RQUA 5BW2A 4HFIA 3P50A 4UXUA 3U8KA 3PEOA 3RI5A 3LSVA 2XZ5A 2PGZA 4TNVA 5AFMB 2XYTA 4ZK1A 2YOEA 4ZR6A 3UQ4A 2XQ8A 4F8HA 5AFLA 5AINA 3UU8A 4B5DA 4IL9A 4DBMA 3TLTA 4ZJSA 3TLWA 2YN6A 3UU4A 5HEJA 3P4WA 4HFEA 3ZKRA 5AFHA 4ILAA 2BYNA 4UM1A 3SQ9A 2BYRA 2YMDA 2WZYA 2XZ6A 2QC1B 4HFBA 3EI0A 4AFGA 5HEHA 3IGQA 4HFCA 4ZK4A 3WTNA 4IREA 4QABA 3ZDGA 4HQPA 3WTMA 2UZ6A 3RIAA 3ZDHA 5BP0A 4A97A 5FJVA 5CO5A 5IUXA 2YMEA 5SYOA 2Y57A 5HEUA 3U8NA 2BG9A 5LG3A 5J5IA 2Y56A 3GUAA 3UU3A 2X00D 4TWDA 2BJ0A 5L47A 2BYSA 2Y54A 4LMLA 3TLSA 2XQ4A 4QH1A 4WV9A 2XNTA 4ILBA 5J5GA 4ZJTA 2XQ6A 4HFHA 4A98A 5AFJA 4UM3S 4Z90A 2ZJVA 2ZJUA 4XHEA 5AFMA 2XNVA 5HEOA 4IL4A 2VL0A 4HFDA 5HCJA 3SH1A 2BG9C 2BR8A 2Y58A 2W8GA 2Y7YA 4QACA 4LMKA 5L4HA 5BRXA 3RQWA 2XQ3A 3U8JA 5J5FA 3SQ6A 4EZ1A 5AFKA 4ILCA 4NZBA 4LMJA 4QAAA 5J0ZA 5J5HA 1I9BA 3UU6A 3SIOA 2W8FA 1UX2A 3PMZA 2BG9E 4Z91A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3UUB A;  2XNU A;  5CFB A;  5JME A;  4AFT A;  2X00 A;  5TVC A;  2PH9 A;  3TLV A;  4QH4 A;  3U8M A;  3WIP A;  2BYQ A;  2WN9 A;  3C79 A;  2C9T A;  3WTI A;  3JAD A;  4XK9 A;  2XYS A;  4TNW A;  2WNL A;  4ZZB A;  4NPP A;  3EAM A;  4BQT A;  4UM3 A;  3WTL A;  3WTO A;  3U8L A;  3WTK A;  2WNJ A;  4D01 A;  4AFH A;  4FRR A;  2WNC A;  5KE4 A;  5HEG A;  5KZU A;  3UU5 A;  2XQ9 A;  3RIF A;  4ALX A;  3WTJ A;  1UV6 A;  3WTH A;  3TLU A;  2YKS A;  4TWF A;  4UY2 A;  4COF A;  2XQA A;  4BFQ A;  3C84 A;  2BG9 B;  2XQ7 A;  3JAF A;  5L4E A;  3EHZ A;  2XQ5 A;  4X5T A;  2BYP A;  4ZRU A;  4ZZC A;  3JAE A;  3UQ7 A;  2BR7 A;  4PIR A;  5LXB A;  5AFN A;  3RHW A;  4QH5 A;  4UM3 P;  1UW6 A;  4TWH A;  3T4M A;  5HCM A;  3RQU A;  5BW2 A;  4HFI A;  3P50 A;  4UXU A;  3U8K A;  3PEO A;  3RI5 A;  3LSV A;  2XZ5 A;  2PGZ A;  4TNV A;  5AFM B;  2XYT A;  4ZK1 A;  2YOE A;  4ZR6 A;  3UQ4 A;  2XQ8 A;  4F8H A;  5AFL A;  5AIN A;  3UU8 A;  4B5D A;  4IL9 A;  4DBM A;  3TLT A;  4ZJS A;  3TLW A;  2YN6 A;  3UU4 A;  5HEJ A;  3P4W A;  4HFE A;  3ZKR A;  5AFH A;  4ILA A;  2BYN A;  4UM1 A;  3SQ9 A;  2BYR A;  2YMD A;  2WZY A;  2XZ6 A;  2QC1 B;  4HFB A;  3EI0 A;  4AFG A;  5HEH A;  3IGQ A;  4HFC A;  4ZK4 A;  3WTN A;  4IRE A;  4QAB A;  3ZDG A;  4HQP A;  3WTM A;  2UZ6 A;  3RIA A;  3ZDH A;  5BP0 A;  4A97 A;  5FJV A;  5CO5 A;  5IUX A;  2YME A;  5SYO A;  2Y57 A;  5HEU A;  3U8N A;  2BG9 A;  5LG3 A;  5J5I A;  2Y56 A;  3GUA A;  3UU3 A;  2X00 D;  4TWD A;  2BJ0 A;  5L47 A;  2BYS A;  2Y54 A;  4LML A;  3TLS A;  2XQ4 A;  4QH1 A;  4WV9 A;  2XNT A;  4ILB A;  5J5G A;  4ZJT A;  2XQ6 A;  4HFH A;  4A98 A;  5AFJ A;  4UM3 S;  4Z90 A;  2ZJV A;  2ZJU A;  4XHE A;  5AFM A;  2XNV A;  5HEO A;  4IL4 A;  2VL0 A;  4HFD A;  5HCJ A;  3SH1 A;  2BG9 C;  2BR8 A;  2Y58 A;  2W8G A;  2Y7Y A;  4QAC A;  4LMK A;  5L4H A;  5BRX A;  3RQW A;  2XQ3 A;  3U8J A;  5J5F A;  3SQ6 A;  4EZ1 A;  5AFK A;  4ILC A;  4NZB A;  4LMJ A;  4QAA A;  5J0Z A;  5J5H A;  1I9B A;  3UU6 A;  3SIO A;  2W8F A;  1UX2 A;  3PMZ A;  2BG9 E;  4Z91 A; 
#chains in the Genus database with same CATH topology
 3UUB A;  2XNU A;  5CFB A;  5JME A;  4AFT A;  2X00 A;  5TVC A;  2PH9 A;  3TLV A;  4QH4 A;  3U8M A;  3WIP A;  2BYQ A;  2WN9 A;  3C79 A;  2C9T A;  3WTI A;  3JAD A;  4XK9 A;  2XYS A;  4TNW A;  2WNL A;  4ZZB A;  4NPP A;  3EAM A;  4BQT A;  4UM3 A;  3WTL A;  3WTO A;  3U8L A;  3WTK A;  2WNJ A;  4D01 A;  4AFH A;  4FRR A;  2WNC A;  5KE4 A;  5HEG A;  5KZU A;  3UU5 A;  2XQ9 A;  3RIF A;  4ALX A;  3WTJ A;  1UV6 A;  3WTH A;  3TLU A;  2YKS A;  4TWF A;  4UY2 A;  4COF A;  2XQA A;  4BFQ A;  3C84 A;  2BG9 B;  2XQ7 A;  3JAF A;  5L4E A;  3EHZ A;  2XQ5 A;  4X5T A;  2BYP A;  4ZRU A;  4ZZC A;  3JAE A;  3UQ7 A;  2BR7 A;  4PIR A;  5LXB A;  5AFN A;  3RHW A;  4QH5 A;  4UM3 P;  1UW6 A;  4TWH A;  3T4M A;  5HCM A;  3RQU A;  5BW2 A;  4HFI A;  3P50 A;  4UXU A;  3U8K A;  3PEO A;  3RI5 A;  3LSV A;  2XZ5 A;  2PGZ A;  4TNV A;  5AFM B;  2XYT A;  4ZK1 A;  2YOE A;  4ZR6 A;  3UQ4 A;  2XQ8 A;  4F8H A;  5AFL A;  5AIN A;  3UU8 A;  4B5D A;  4IL9 A;  4DBM A;  3TLT A;  4ZJS A;  3TLW A;  2YN6 A;  3UU4 A;  5HEJ A;  3P4W A;  4HFE A;  3ZKR A;  5AFH A;  4ILA A;  2BYN A;  4UM1 A;  3SQ9 A;  2BYR A;  2YMD A;  2WZY A;  2XZ6 A;  2QC1 B;  4HFB A;  3EI0 A;  4AFG A;  5HEH A;  3IGQ A;  4HFC A;  4ZK4 A;  3WTN A;  4IRE A;  4QAB A;  3ZDG A;  4HQP A;  3WTM A;  2UZ6 A;  3RIA A;  3ZDH A;  5BP0 A;  4A97 A;  5FJV A;  5CO5 A;  5IUX A;  2YME A;  5SYO A;  2Y57 A;  5HEU A;  3U8N A;  2BG9 A;  5LG3 A;  5J5I A;  2Y56 A;  3GUA A;  3UU3 A;  2X00 D;  4TWD A;  2BJ0 A;  5L47 A;  2BYS A;  2Y54 A;  4LML A;  3TLS A;  2XQ4 A;  4QH1 A;  4WV9 A;  2XNT A;  4ILB A;  5J5G A;  4ZJT A;  2XQ6 A;  4HFH A;  4A98 A;  5AFJ A;  4UM3 S;  4Z90 A;  2ZJV A;  2ZJU A;  4XHE A;  5AFM A;  2XNV A;  5HEO A;  4IL4 A;  2VL0 A;  4HFD A;  5HCJ A;  3SH1 A;  2BG9 C;  2BR8 A;  2Y58 A;  2W8G A;  2Y7Y A;  4QAC A;  4LMK A;  5L4H A;  5BRX A;  3RQW A;  2XQ3 A;  3U8J A;  5J5F A;  3SQ6 A;  4EZ1 A;  5AFK A;  4ILC A;  4NZB A;  4LMJ A;  4QAA A;  5J0Z A;  5J5H A;  1I9B A;  3UU6 A;  3SIO A;  2W8F A;  1UX2 A;  3PMZ A;  2BG9 E;  4Z91 A; 
#chains in the Genus database with same CATH homology
 3UUB A;  2XNU A;  5CFB A;  5JME A;  4AFT A;  2X00 A;  5TVC A;  2PH9 A;  3TLV A;  4QH4 A;  3U8M A;  3WIP A;  2BYQ A;  2WN9 A;  3C79 A;  2C9T A;  3WTI A;  3JAD A;  4XK9 A;  2XYS A;  4TNW A;  2WNL A;  4ZZB A;  4NPP A;  3EAM A;  4BQT A;  4UM3 A;  3WTL A;  3WTO A;  3U8L A;  3WTK A;  2WNJ A;  4D01 A;  4AFH A;  4FRR A;  2WNC A;  5KE4 A;  5HEG A;  5KZU A;  3UU5 A;  2XQ9 A;  3RIF A;  4ALX A;  3WTJ A;  1UV6 A;  3WTH A;  3TLU A;  2YKS A;  4TWF A;  4UY2 A;  4COF A;  2XQA A;  4BFQ A;  3C84 A;  2BG9 B;  2XQ7 A;  3JAF A;  5L4E A;  3EHZ A;  2XQ5 A;  4X5T A;  2BYP A;  4ZRU A;  4ZZC A;  3JAE A;  3UQ7 A;  2BR7 A;  4PIR A;  5LXB A;  5AFN A;  3RHW A;  4QH5 A;  4UM3 P;  1UW6 A;  4TWH A;  3T4M A;  5HCM A;  3RQU A;  5BW2 A;  4HFI A;  3P50 A;  4UXU A;  3U8K A;  3PEO A;  3RI5 A;  3LSV A;  2XZ5 A;  2PGZ A;  4TNV A;  5AFM B;  2XYT A;  4ZK1 A;  2YOE A;  4ZR6 A;  3UQ4 A;  2XQ8 A;  4F8H A;  5AFL A;  5AIN A;  3UU8 A;  4B5D A;  4IL9 A;  4DBM A;  3TLT A;  4ZJS A;  3TLW A;  2YN6 A;  3UU4 A;  5HEJ A;  3P4W A;  4HFE A;  3ZKR A;  5AFH A;  4ILA A;  2BYN A;  4UM1 A;  3SQ9 A;  2BYR A;  2YMD A;  2WZY A;  2XZ6 A;  2QC1 B;  4HFB A;  3EI0 A;  4AFG A;  5HEH A;  3IGQ A;  4HFC A;  4ZK4 A;  3WTN A;  4IRE A;  4QAB A;  3ZDG A;  4HQP A;  3WTM A;  2UZ6 A;  3RIA A;  3ZDH A;  5BP0 A;  4A97 A;  5FJV A;  5CO5 A;  5IUX A;  2YME A;  5SYO A;  2Y57 A;  5HEU A;  3U8N A;  2BG9 A;  5LG3 A;  5J5I A;  2Y56 A;  3GUA A;  3UU3 A;  2X00 D;  4TWD A;  2BJ0 A;  5L47 A;  2BYS A;  2Y54 A;  4LML A;  3TLS A;  2XQ4 A;  4QH1 A;  4WV9 A;  2XNT A;  4ILB A;  5J5G A;  4ZJT A;  2XQ6 A;  4HFH A;  4A98 A;  5AFJ A;  4UM3 S;  4Z90 A;  2ZJV A;  2ZJU A;  4XHE A;  5AFM A;  2XNV A;  5HEO A;  4IL4 A;  2VL0 A;  4HFD A;  5HCJ A;  3SH1 A;  2BG9 C;  2BR8 A;  2Y58 A;  2W8G A;  2Y7Y A;  4QAC A;  4LMK A;  5L4H A;  5BRX A;  3RQW A;  2XQ3 A;  3U8J A;  5J5F A;  3SQ6 A;  4EZ1 A;  5AFK A;  4ILC A;  4NZB A;  4LMJ A;  4QAA A;  5J0Z A;  5J5H A;  1I9B A;  3UU6 A;  3SIO A;  2W8F A;  1UX2 A;  3PMZ A;  2BG9 E;  4Z91 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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