1C21A

E. coli methionine aminopeptidase: methionine complex
Total Genus 88
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
88
sequence length
262
structure length
262
Chain Sequence
AISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGQGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHD
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Insights into the mechanism of Escherichia coli methionine aminopeptidase from the structural analysis of reaction products and phosphorus-based transition-state analogues.
pubmed doi rcsb
molecule tags Hydrolase
source organism Escherichia coli
molecule keywords METHIONINE AMINOPEPTIDASE
total genus 88
structure length 262
sequence length 262
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 1999-07-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 1c21A00
4HXXA 2BH3A 2BWUA 2GG9A 2GA2A 5CDVA 2V6CA 1W7VA 1R5HA 2Q95A 2Q96A 3FM3A 1QXZA 3PKBA 5JHUA 3FMQA 2B3HA 4IPAA 4IF7A 2MATA 4U1BA 1R5GA 1WLRA 3CTZA 1A16A 2EVMA 4KM3A 5CNXA 3S6BA 1B6AA 1KQ9A 4U6EA 1JAWA 4IKSA 4U75A 1YVMA 3TB5A 1XGSA 1C22A 3BIPA 2Q93A 4ZWOA 3PKEA 2EVCA 2V3YA 4FO8A 1KP0A 4R60A 4U70A 1YW8A 2BHAA 2GG5A 1N51A 4U6ZA 2GGCA 1C21A 4U6WA 4PV4A 4S2TP 4OOKA 2BWVA 1W2MA 3CB6A 3MATA 4FUKA 4IU6A 4A6VA 2GG8A 4S2RP 1MATA 2BWSA 1M35A 1YW9A 2BHDA 2EA4A 2EVOA 1WKMA 2GG0A 2NQ7A 2V3ZA 3IU8A 4IKUA 4U71A 5D6EA 2V3XA 4U73A 5CDLA 4U76A 1O0XA 3MX6A 4JUQA 1QZYA 3RVAA 2GG3A 1XGMA 2ZSGA 2BWTA 4FLKA 2B3LA 1WN1A 1R58A 1YW7A 4IDYA 2NQ6A 1WL9A 4FKCA 4IKRA 3PKAA 4QR8A 4S00A 4U6JA 4B28A 4FLJA 3BIQA 5CDEA 1BN5A 3D27A 4U6CA 1Y1NA 2BHBA 1CHMA 1WL6A 3MR1A 2OAZA 4U69A 2OKNA 1XGNA 5CE6A 1C23A 2BWYA 4RGZ1 3TAVA 5CIKA 1BOAA 1WY2A 1XGOA 2GZ5A 5CLSA 4A6WA 2B3KA 1XNZA 4EGEA 4S01A 5JFRA 2GG7A 3Q6DA 2IW2A 4FLIA 4MATA 3PKDA 3L24A 2GU7A 3IG4A 1PV9A 2P99A 3IU9A 2Q92A 4FO7A 1QXWA 2GU5A 2BHCA 4RZZA 2Q94A 3FMRA 5E5BA 2Q8KA 5JI6A 4IKTA 3BITA 5FCFA 2G6PA 4IECA 4FLLA 4PNCA 1WBQA 2ADUA 1YJ3A 3RORA 3CB5A 1C27A 2GGBA 4ZWUA 1B59A 2GU4A 2BB7A 2GTXA 2GU6A 2GG2A 3IU7A 4ZWPA 5D6FA 2DFIA 4RZYA 5FCHA 4Z7MA 2HOWA 1C24A 3PKCA 4ZNGA 3L7GA 2BWWA 2EA2A 1KQ0A 2P9AA 2BN7A 1QXYA 2BWXA 2P98A
chains in the Genus database with same CATH superfamily
4HXXA 2BH3A 2BWUA 2GG9A 2GA2A 5CDVA 2V6CA 1W7VA 1R5HA 2Q95A 2Q96A 3FM3A 1QXZA 3PKBA 5JHUA 3FMQA 2B3HA 4IPAA 4IF7A 2MATA 4U1BA 1R5GA 1WLRA 3CTZA 1A16A 2EVMA 4KM3A 5CNXA 3S6BA 1B6AA 1KQ9A 4U6EA 1JAWA 4IKSA 4U75A 1YVMA 3TB5A 1XGSA 1C22A 3BIPA 2Q93A 4ZWOA 3PKEA 2EVCA 2V3YA 4FO8A 1KP0A 4R60A 4U70A 1YW8A 2BHAA 2GG5A 1N51A 4U6ZA 2GGCA 1C21A 4U6WA 4PV4A 4S2TP 4OOKA 2BWVA 1W2MA 3CB6A 3MATA 4FUKA 4IU6A 4A6VA 2GG8A 4S2RP 1MATA 2BWSA 1M35A 1YW9A 2BHDA 2EA4A 2EVOA 1WKMA 2GG0A 2NQ7A 2V3ZA 3IU8A 4IKUA 4U71A 5D6EA 2V3XA 4U73A 5CDLA 4U76A 1O0XA 3MX6A 4JUQA 1QZYA 3RVAA 2GG3A 1XGMA 2ZSGA 2BWTA 4FLKA 2B3LA 1WN1A 1R58A 1YW7A 4IDYA 2NQ6A 1WL9A 4FKCA 4IKRA 3PKAA 4QR8A 4S00A 4U6JA 4B28A 4FLJA 3BIQA 5CDEA 1BN5A 3D27A 4U6CA 1Y1NA 2BHBA 1CHMA 1WL6A 3MR1A 2OAZA 4U69A 2OKNA 1XGNA 5CE6A 1C23A 2BWYA 4RGZ1 3TAVA 5CIKA 1BOAA 1WY2A 1XGOA 2GZ5A 5CLSA 4A6WA 2B3KA 1XNZA 4EGEA 4S01A 5JFRA 2GG7A 3Q6DA 2IW2A 4FLIA 4MATA 3PKDA 3L24A 2GU7A 3IG4A 1PV9A 2P99A 3IU9A 2Q92A 4FO7A 1QXWA 2GU5A 2BHCA 4RZZA 2Q94A 3FMRA 5E5BA 2Q8KA 5JI6A 4IKTA 3BITA 5FCFA 2G6PA 4IECA 4FLLA 4PNCA 1WBQA 2ADUA 1YJ3A 3RORA 3CB5A 1C27A 2GGBA 4ZWUA 1B59A 2GU4A 2BB7A 2GTXA 2GU6A 2GG2A 3IU7A 4ZWPA 5D6FA 2DFIA 4RZYA 5FCHA 4Z7MA 2HOWA 1C24A 3PKCA 4ZNGA 3L7GA 2BWWA 2EA2A 1KQ0A 2P9AA 2BN7A 1QXYA 2BWXA 2P98A
chains in the Genus database with same CATH topology
4HXXA 2BH3A 2BWUA 2GG9A 2GA2A 5CDVA 2V6CA 1W7VA 1R5HA 2Q95A 2Q96A 3FM3A 1QXZA 3PKBA 5JHUA 3FMQA 2B3HA 4IPAA 4IF7A 2MATA 4U1BA 1R5GA 1WLRA 3CTZA 1A16A 2EVMA 4KM3A 5CNXA 3S6BA 1B6AA 1KQ9A 4U6EA 1JAWA 4IKSA 4U75A 1YVMA 3TB5A 1XGSA 1C22A 3BIPA 2Q93A 4ZWOA 3PKEA 2EVCA 2V3YA 4FO8A 1KP0A 4R60A 4U70A 1YW8A 2BHAA 2GG5A 1N51A 4U6ZA 2GGCA 1C21A 4U6WA 4PV4A 4S2TP 4OOKA 2BWVA 1W2MA 3CB6A 3MATA 4FUKA 4IU6A 4A6VA 2GG8A 4S2RP 1MATA 2BWSA 1M35A 1YW9A 2BHDA 2EA4A 2EVOA 1WKMA 2GG0A 2NQ7A 2V3ZA 3IU8A 4IKUA 4U71A 5D6EA 2V3XA 4U73A 5CDLA 4U76A 1O0XA 3MX6A 4JUQA 1QZYA 3RVAA 2GG3A 1XGMA 2ZSGA 2BWTA 4FLKA 2B3LA 1WN1A 1R58A 1YW7A 4IDYA 2NQ6A 1WL9A 4FKCA 4IKRA 3PKAA 4QR8A 4S00A 4U6JA 4B28A 4FLJA 3BIQA 5CDEA 1BN5A 3D27A 4U6CA 1Y1NA 2BHBA 1CHMA 1WL6A 3MR1A 2OAZA 4U69A 2OKNA 1XGNA 5CE6A 1C23A 2BWYA 4RGZ1 3TAVA 5CIKA 1BOAA 1WY2A 1XGOA 2GZ5A 5CLSA 4A6WA 2B3KA 1XNZA 4EGEA 4S01A 5JFRA 2GG7A 3Q6DA 2IW2A 4FLIA 4MATA 3PKDA 3L24A 2GU7A 3IG4A 1PV9A 2P99A 3IU9A 2Q92A 4FO7A 1QXWA 2GU5A 2BHCA 4RZZA 2Q94A 3FMRA 5E5BA 2Q8KA 5JI6A 4IKTA 3BITA 5FCFA 2G6PA 4IECA 4FLLA 4PNCA 1WBQA 2ADUA 1YJ3A 3RORA 3CB5A 1C27A 2GGBA 4ZWUA 1B59A 2GU4A 2BB7A 2GTXA 2GU6A 2GG2A 3IU7A 4ZWPA 5D6FA 2DFIA 4RZYA 5FCHA 4Z7MA 2HOWA 1C24A 3PKCA 4ZNGA 3L7GA 2BWWA 2EA2A 1KQ0A 2P9AA 2BN7A 1QXYA 2BWXA 2P98A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4HXX A;  2BH3 A;  2BWU A;  2GG9 A;  2GA2 A;  5CDV A;  2V6C A;  1W7V A;  1R5H A;  2Q95 A;  2Q96 A;  3FM3 A;  1QXZ A;  3PKB A;  5JHU A;  3FMQ A;  2B3H A;  4IPA A;  4IF7 A;  2MAT A;  4U1B A;  1R5G A;  1WLR A;  3CTZ A;  1A16 A;  2EVM A;  4KM3 A;  5CNX A;  3S6B A;  1B6A A;  1KQ9 A;  4U6E A;  1JAW A;  4IKS A;  4U75 A;  1YVM A;  3TB5 A;  1XGS A;  1C22 A;  3BIP A;  2Q93 A;  4ZWO A;  3PKE A;  2EVC A;  2V3Y A;  4FO8 A;  1KP0 A;  4R60 A;  4U70 A;  1YW8 A;  2BHA A;  2GG5 A;  1N51 A;  4U6Z A;  2GGC A;  1C21 A;  4U6W A;  4PV4 A;  4S2T P;  4OOK A;  2BWV A;  1W2M A;  3CB6 A;  3MAT A;  4FUK A;  4IU6 A;  4A6V A;  2GG8 A;  4S2R P;  1MAT A;  2BWS A;  1M35 A;  1YW9 A;  2BHD A;  2EA4 A;  2EVO A;  1WKM A;  2GG0 A;  2NQ7 A;  2V3Z A;  3IU8 A;  4IKU A;  4U71 A;  5D6E A;  2V3X A;  4U73 A;  5CDL A;  4U76 A;  1O0X A;  3MX6 A;  4JUQ A;  1QZY A;  3RVA A;  2GG3 A;  1XGM A;  2ZSG A;  2BWT A;  4FLK A;  2B3L A;  1WN1 A;  1R58 A;  1YW7 A;  4IDY A;  2NQ6 A;  1WL9 A;  4FKC A;  4IKR A;  3PKA A;  4QR8 A;  4S00 A;  4U6J A;  4B28 A;  4FLJ A;  3BIQ A;  5CDE A;  1BN5 A;  3D27 A;  4U6C A;  1Y1N A;  2BHB A;  1CHM A;  1WL6 A;  3MR1 A;  2OAZ A;  4U69 A;  2OKN A;  1XGN A;  5CE6 A;  1C23 A;  2BWY A;  4RGZ 1;  3TAV A;  5CIK A;  1BOA A;  1WY2 A;  1XGO A;  2GZ5 A;  5CLS A;  4A6W A;  2B3K A;  1XNZ A;  4EGE A;  4S01 A;  5JFR A;  2GG7 A;  3Q6D A;  2IW2 A;  4FLI A;  4MAT A;  3PKD A;  3L24 A;  2GU7 A;  3IG4 A;  1PV9 A;  2P99 A;  3IU9 A;  2Q92 A;  4FO7 A;  1QXW A;  2GU5 A;  2BHC A;  4RZZ A;  2Q94 A;  3FMR A;  5E5B A;  2Q8K A;  5JI6 A;  4IKT A;  3BIT A;  5FCF A;  2G6P A;  4IEC A;  4FLL A;  4PNC A;  1WBQ A;  2ADU A;  1YJ3 A;  3ROR A;  3CB5 A;  1C27 A;  2GGB A;  4ZWU A;  1B59 A;  2GU4 A;  2BB7 A;  2GTX A;  2GU6 A;  2GG2 A;  3IU7 A;  4ZWP A;  5D6F A;  2DFI A;  4RZY A;  5FCH A;  4Z7M A;  2HOW A;  1C24 A;  3PKC A;  4ZNG A;  3L7G A;  2BWW A;  2EA2 A;  1KQ0 A;  2P9A A;  2BN7 A;  1QXY A;  2BWX A;  2P98 A; 
#chains in the Genus database with same CATH topology
 4HXX A;  2BH3 A;  2BWU A;  2GG9 A;  2GA2 A;  5CDV A;  2V6C A;  1W7V A;  1R5H A;  2Q95 A;  2Q96 A;  3FM3 A;  1QXZ A;  3PKB A;  5JHU A;  3FMQ A;  2B3H A;  4IPA A;  4IF7 A;  2MAT A;  4U1B A;  1R5G A;  1WLR A;  3CTZ A;  1A16 A;  2EVM A;  4KM3 A;  5CNX A;  3S6B A;  1B6A A;  1KQ9 A;  4U6E A;  1JAW A;  4IKS A;  4U75 A;  1YVM A;  3TB5 A;  1XGS A;  1C22 A;  3BIP A;  2Q93 A;  4ZWO A;  3PKE A;  2EVC A;  2V3Y A;  4FO8 A;  1KP0 A;  4R60 A;  4U70 A;  1YW8 A;  2BHA A;  2GG5 A;  1N51 A;  4U6Z A;  2GGC A;  1C21 A;  4U6W A;  4PV4 A;  4S2T P;  4OOK A;  2BWV A;  1W2M A;  3CB6 A;  3MAT A;  4FUK A;  4IU6 A;  4A6V A;  2GG8 A;  4S2R P;  1MAT A;  2BWS A;  1M35 A;  1YW9 A;  2BHD A;  2EA4 A;  2EVO A;  1WKM A;  2GG0 A;  2NQ7 A;  2V3Z A;  3IU8 A;  4IKU A;  4U71 A;  5D6E A;  2V3X A;  4U73 A;  5CDL A;  4U76 A;  1O0X A;  3MX6 A;  4JUQ A;  1QZY A;  3RVA A;  2GG3 A;  1XGM A;  2ZSG A;  2BWT A;  4FLK A;  2B3L A;  1WN1 A;  1R58 A;  1YW7 A;  4IDY A;  2NQ6 A;  1WL9 A;  4FKC A;  4IKR A;  3PKA A;  4QR8 A;  4S00 A;  4U6J A;  4B28 A;  4FLJ A;  3BIQ A;  5CDE A;  1BN5 A;  3D27 A;  4U6C A;  1Y1N A;  2BHB A;  1CHM A;  1WL6 A;  3MR1 A;  2OAZ A;  4U69 A;  2OKN A;  1XGN A;  5CE6 A;  1C23 A;  2BWY A;  4RGZ 1;  3TAV A;  5CIK A;  1BOA A;  1WY2 A;  1XGO A;  2GZ5 A;  5CLS A;  4A6W A;  2B3K A;  1XNZ A;  4EGE A;  4S01 A;  5JFR A;  2GG7 A;  3Q6D A;  2IW2 A;  4FLI A;  4MAT A;  3PKD A;  3L24 A;  2GU7 A;  3IG4 A;  1PV9 A;  2P99 A;  3IU9 A;  2Q92 A;  4FO7 A;  1QXW A;  2GU5 A;  2BHC A;  4RZZ A;  2Q94 A;  3FMR A;  5E5B A;  2Q8K A;  5JI6 A;  4IKT A;  3BIT A;  5FCF A;  2G6P A;  4IEC A;  4FLL A;  4PNC A;  1WBQ A;  2ADU A;  1YJ3 A;  3ROR A;  3CB5 A;  1C27 A;  2GGB A;  4ZWU A;  1B59 A;  2GU4 A;  2BB7 A;  2GTX A;  2GU6 A;  2GG2 A;  3IU7 A;  4ZWP A;  5D6F A;  2DFI A;  4RZY A;  5FCH A;  4Z7M A;  2HOW A;  1C24 A;  3PKC A;  4ZNG A;  3L7G A;  2BWW A;  2EA2 A;  1KQ0 A;  2P9A A;  2BN7 A;  1QXY A;  2BWX A;  2P98 A; 
#chains in the Genus database with same CATH homology
 4HXX A;  2BH3 A;  2BWU A;  2GG9 A;  2GA2 A;  5CDV A;  2V6C A;  1W7V A;  1R5H A;  2Q95 A;  2Q96 A;  3FM3 A;  1QXZ A;  3PKB A;  5JHU A;  3FMQ A;  2B3H A;  4IPA A;  4IF7 A;  2MAT A;  4U1B A;  1R5G A;  1WLR A;  3CTZ A;  1A16 A;  2EVM A;  4KM3 A;  5CNX A;  3S6B A;  1B6A A;  1KQ9 A;  4U6E A;  1JAW A;  4IKS A;  4U75 A;  1YVM A;  3TB5 A;  1XGS A;  1C22 A;  3BIP A;  2Q93 A;  4ZWO A;  3PKE A;  2EVC A;  2V3Y A;  4FO8 A;  1KP0 A;  4R60 A;  4U70 A;  1YW8 A;  2BHA A;  2GG5 A;  1N51 A;  4U6Z A;  2GGC A;  1C21 A;  4U6W A;  4PV4 A;  4S2T P;  4OOK A;  2BWV A;  1W2M A;  3CB6 A;  3MAT A;  4FUK A;  4IU6 A;  4A6V A;  2GG8 A;  4S2R P;  1MAT A;  2BWS A;  1M35 A;  1YW9 A;  2BHD A;  2EA4 A;  2EVO A;  1WKM A;  2GG0 A;  2NQ7 A;  2V3Z A;  3IU8 A;  4IKU A;  4U71 A;  5D6E A;  2V3X A;  4U73 A;  5CDL A;  4U76 A;  1O0X A;  3MX6 A;  4JUQ A;  1QZY A;  3RVA A;  2GG3 A;  1XGM A;  2ZSG A;  2BWT A;  4FLK A;  2B3L A;  1WN1 A;  1R58 A;  1YW7 A;  4IDY A;  2NQ6 A;  1WL9 A;  4FKC A;  4IKR A;  3PKA A;  4QR8 A;  4S00 A;  4U6J A;  4B28 A;  4FLJ A;  3BIQ A;  5CDE A;  1BN5 A;  3D27 A;  4U6C A;  1Y1N A;  2BHB A;  1CHM A;  1WL6 A;  3MR1 A;  2OAZ A;  4U69 A;  2OKN A;  1XGN A;  5CE6 A;  1C23 A;  2BWY A;  4RGZ 1;  3TAV A;  5CIK A;  1BOA A;  1WY2 A;  1XGO A;  2GZ5 A;  5CLS A;  4A6W A;  2B3K A;  1XNZ A;  4EGE A;  4S01 A;  5JFR A;  2GG7 A;  3Q6D A;  2IW2 A;  4FLI A;  4MAT A;  3PKD A;  3L24 A;  2GU7 A;  3IG4 A;  1PV9 A;  2P99 A;  3IU9 A;  2Q92 A;  4FO7 A;  1QXW A;  2GU5 A;  2BHC A;  4RZZ A;  2Q94 A;  3FMR A;  5E5B A;  2Q8K A;  5JI6 A;  4IKT A;  3BIT A;  5FCF A;  2G6P A;  4IEC A;  4FLL A;  4PNC A;  1WBQ A;  2ADU A;  1YJ3 A;  3ROR A;  3CB5 A;  1C27 A;  2GGB A;  4ZWU A;  1B59 A;  2GU4 A;  2BB7 A;  2GTX A;  2GU6 A;  2GG2 A;  3IU7 A;  4ZWP A;  5D6F A;  2DFI A;  4RZY A;  5FCH A;  4Z7M A;  2HOW A;  1C24 A;  3PKC A;  4ZNG A;  3L7G A;  2BWW A;  2EA2 A;  1KQ0 A;  2P9A A;  2BN7 A;  1QXY A;  2BWX A;  2P98 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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